☰

cached image

Amanda E. Hargrove, Ph.D. - Publications

Affiliations: 
2005-2010 Chemistry University of Texas, Austin, Texas 
 2010-2013 Chemistry California Institute of Technology, Pasadena, CA 
 2013- Chemistry Duke University, Durham, NC 
Area:
Bio-organic chemistry
Website:
https://chem.duke.edu/labs/hargrove/amanda-hargrove
Tree Info Similar researchers PubMed Report error

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bailey MA, Martyr JG, Hargrove AE, Fitzgerald MC. Stability-Based Proteomics for Investigation of Structured RNA-Protein Interactions. Analytical Chemistry. PMID 38341805 DOI: 10.1021/acs.analchem.3c04978  0.335
2023 Wicks SL, Morgan BS, Wilson AW, Hargrove AE. Probing Bioactive Chemical Space to Discover RNA-Targeted Small Molecules. Biorxiv : the Preprint Server For Biology. PMID 37577658 DOI: 10.1101/2023.07.31.551350  0.779
2023 Bagnolini G, Luu TB, Hargrove AE. Recognizing the power of machine learning and other computational methods to accelerate progress in small molecule targeting of RNA. Rna (New York, N.Y.). PMID 36693763 DOI: 10.1261/rna.079497.122  0.381
2022 Zafferani M, Martyr JG, Muralidharan D, Montalvan NI, Cai Z, Hargrove AE. Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability . Acs Chemical Biology. PMID 35984959 DOI: 10.1021/acschembio.2c00124  0.409
2022 Zafferani M, Muralidharan D, Montalvan NI, Hargrove AE. RT-qPCR as a screening platform for mutational and small molecule impacts on structural stability of RNA tertiary structures. Rsc Chemical Biology. 3: 905-915. PMID 35866161 DOI: 10.1039/d2cb00015f  0.362
2022 Donlic A, Swanson EG, Chiu LY, Wicks SL, Juru AU, Cai Z, Kassam K, Laudeman C, Sanaba BG, Sugarman A, Han E, Tolbert BS, Hargrove AE. R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures. Acs Chemical Biology. 17: 1556-1566. PMID 35594415 DOI: 10.1021/acschembio.2c00224  0.78
2022 Cai Z, Zafferani M, Akande OM, Hargrove AE. Quantitative Structure-Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure. Journal of Medicinal Chemistry. 65: 7262-7277. PMID 35522972 DOI: 10.1021/acs.jmedchem.2c00254  0.398
2021 Zafferani M, Haddad C, Luo L, Davila-Calderon J, Chiu LY, Mugisha CS, Monaghan AG, Kennedy AA, Yesselman JD, Gifford RJ, Tai AW, Kutluay SB, Li ML, Brewer G, Tolbert BS, ... Hargrove AE, et al. Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures. Science Advances. 7: eabl6096. PMID 34826236 DOI: 10.1126/sciadv.abl6096  0.316
2021 Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, ... ... Hargrove AE, et al. Noncoding RNAs: biology and applications-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34791665 DOI: 10.1111/nyas.14713  0.332
2021 Zafferani M, Hargrove AE. Small molecule targeting of biologically relevant RNA tertiary and quaternary structures. Cell Chemical Biology. PMID 33823146 DOI: 10.1016/j.chembiol.2021.03.003  0.406
2021 Falese JP, Donlic A, Hargrove AE. Targeting RNA with small molecules: from fundamental principles towards the clinic. Chemical Society Reviews. PMID 33458725 DOI: 10.1039/d0cs01261k  0.337
2020 Umuhire Juru A, Hargrove AE. Frameworks for targeting RNA with small molecules. The Journal of Biological Chemistry. PMID 33334887 DOI: 10.1074/jbc.REV120.015203  0.418
2020 Zafferani M, Haddad C, Luo L, Davila-Calderon J, Yuan-Chiu L, Shema Mugisha C, Monaghan AG, Kennedy AA, Yesselman JD, Gifford RR, Tai AW, Kutluay SB, Li ML, Brewer G, Tolbert BS, ... Hargrove AE, et al. Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures. Biorxiv : the Preprint Server For Biology. PMID 33299997 DOI: 10.1101/2020.12.05.409821  0.384
2020 Hargrove AE. Small molecule-RNA targeting: starting with the fundamentals. Chemical Communications (Cambridge, England). 56: 14744-14756. PMID 33201954 DOI: 10.1039/d0cc06796b  0.415
2020 Davila-Calderon J, Patwardhan NN, Chiu LY, Sugarman A, Cai Z, Penutmutchu SR, Li ML, Brewer G, Hargrove AE, Tolbert BS. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nature Communications. 11: 4775. PMID 32963221 DOI: 10.1038/s41467-020-18594-3  0.343
2020 Donlic A, Zafferani M, Padroni G, Puri M, Hargrove AE. Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans. Nucleic Acids Research. PMID 32667657 DOI: 10.1093/Nar/Gkaa585  0.495
2020 Umuhire Juru A, Cai Z, Jan A, Hargrove AE. Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry. Chemical Communications (Cambridge, England). PMID 32104839 DOI: 10.1039/D0Cc00266F  0.438
2020 Davila-Calderon J, Patwardhan N, Yuang-Chiu L, Sugarman A, Cai Z, Penutmutchu S, Li M, Brewer G, Hargrove A, Tolbert BS. Small Molecule Inhibits Enterovirus 71 Replication by Targeting the IRES Domain The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04874  0.317
2020 McFadden EJ, Donlic A, Falese J, Kassam K, Hargrove A. Analysis of Long‐noncoding RNA Structure‐Function Relationship in Prostate Cancer The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00111  0.338
2020 Padroni G, Patwardhan NN, Schapira M, Hargrove AE. Systematic analysis of the interactions driving small molecule–RNA recognition Rsc Medicinal Chemistry. 11: 802-813. DOI: 10.1039/d0md00167h  0.321
2019 Ganser LR, Kelly ML, Patwardhan NN, Hargrove AE, Al-Hashimi HM. Demonstration that small molecules can bind and stabilize low-abundance short-lived RNA excited conformational states. Journal of Molecular Biology. PMID 31863746 DOI: 10.1016/J.Jmb.2019.12.009  0.499
2019 Patwardhan NN, Cai Z, Umuhire Juru A, Hargrove AE. Driving factors in amiloride recognition of HIV RNA targets. Organic & Biomolecular Chemistry. PMID 31612165 DOI: 10.1039/C9Ob01702J  0.481
2019 Morgan BS, Sanaba BG, Donlic A, Karloff DB, Forte JE, Zhang Y, Hargrove AE. R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes. Acs Chemical Biology. PMID 31589399 DOI: 10.1021/Acschembio.9B00631  0.501
2019 Hargrove AE. Methods to identify and characterize RNA-targeting small molecules. Methods (San Diego, Calif.). PMID 31381979 DOI: 10.1016/J.Ymeth.2019.08.001  0.461
2019 Padroni G, Eubanks CS, Hargrove AE. Differentiation and classification of RNA motifs using small molecule-based pattern recognition. Methods in Enzymology. 623: 101-130. PMID 31239043 DOI: 10.1016/Bs.Mie.2019.05.022  0.475
2019 Wicks SL, Hargrove AE. Fluorescent Indicator Displacement Assays to Identify and Characterize Small Molecule Interactions with RNA. Methods (San Diego, Calif.). PMID 31051253 DOI: 10.1016/J.Ymeth.2019.04.018  0.775
2019 Umuhire Juru A, Patwardhan NN, Hargrove AE. Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions. Acs Chemical Biology. PMID 31042354 DOI: 10.1021/Acschembio.8B00945  0.491
2019 Donlic A, Morgan BS, Xu JL, Liu A, Roble C, Hargrove AE. Corrigendum: Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold. Angewandte Chemie (International Ed. in English). 58: 5482. PMID 30964243 DOI: 10.1002/Anie.201900875  0.491
2019 Eubanks CS, Zhao B, Patwardhan NN, Thompson RD, Zhang Q, Hargrove AE. Visualizing RNA conformational changes via Pattern Recognition of RNA by Small Molecules. Journal of the American Chemical Society. PMID 30860826 DOI: 10.1021/Jacs.8B09665  0.451
2019 Donlic A, Morgan BS, Xu JL, Liu A, Roble C, Hargrove AE. Berichtigung: Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA‐Binding Scaffold Angewandte Chemie. 131: 5537-5537. DOI: 10.1002/Ange.201900875  0.358
2018 Eubanks CS, Hargrove AE. RNA Structural Differentiation: Opportunities with Pattern Recognition. Biochemistry. PMID 30513196 DOI: 10.1021/Acs.Biochem.8B01090  0.47
2018 Patwardhan NN, Cai Z, Newson CN, Hargrove AE. Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA. Organic & Biomolecular Chemistry. PMID 30468226 DOI: 10.1039/C8Ob02467G  0.454
2018 Donlic A, Morgan BS, Xu JL, Liu A, Roble C, Hargrove AE. Discovery of the First Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold. Angewandte Chemie (International Ed. in English). PMID 30134013 DOI: 10.1002/Anie.201808823  0.519
2018 Morgan BS, Forte JE, Hargrove AE. Insights into the development of chemical probes for RNA. Nucleic Acids Research. PMID 30102391 DOI: 10.1093/Nar/Gky718  0.485
2018 Donlic A, Hargrove AE. Targeting RNA in mammalian systems with small molecules. Wiley Interdisciplinary Reviews. Rna. e1477. PMID 29726113 DOI: 10.1002/Wrna.1477  0.484
2017 Eubanks CS, Hargrove AE. Sensing the impact of environment on small molecule differentiation of RNA sequences. Chemical Communications (Cambridge, England). 53: 13363-13366. PMID 29199743 DOI: 10.1039/C7Cc07157D  0.465
2017 Morgan BS, Forte JE, Culver RN, Zhang Y, Hargrove AE. Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-targeted Bioactive Ligands. Angewandte Chemie (International Ed. in English). PMID 28810078 DOI: 10.1002/Anie.201707641  0.506
2017 Patwardhan NN, Ganser LR, Kapral GJ, Eubanks CS, Lee J, Sathyamoorthy B, Al-Hashimi HM, Hargrove AE. Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR. Medchemcomm. 8: 1022-1036. PMID 28798862 DOI: 10.1039/C6Md00729E  0.468
2016 Eubanks CS, Forte JE, Kapral GJ, Hargrove AE. Small Molecule-Based Pattern Recognition To Classify RNA Structure. Journal of the American Chemical Society. PMID 28004925 DOI: 10.1021/Jacs.6B11087  0.474
2016 McFadden EJ, Hargrove AE. Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin. Biochemistry. 55: 1615-30. PMID 26859437 DOI: 10.1021/Acs.Biochem.5B01141  0.4
2015 Hargrove AE, Martinez TF, Hare AA, Kurmis AA, Phillips JW, Sud S, Pienta KJ, Dervan PB. Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide. Plos One. 10: e0143161. PMID 26571387 DOI: 10.1371/Journal.Pone.0143161  0.726
2015 Burg JM, Link JE, Morgan BS, Heller FJ, Hargrove AE, McCafferty DG. KDM1 Class Flavin-Dependent Protein Lysine Demethylases. Biopolymers. PMID 25787087 DOI: 10.1002/Bip.22643  0.337
2013 Nickols NG, Szablowski JO, Hargrove AE, Li BC, Raskatov JA, Dervan PB. Activity of a Py-Im polyamide targeted to the estrogen response element. Molecular Cancer Therapeutics. 12: 675-84. PMID 23443804 DOI: 10.1158/1535-7163.Mct-12-1040  0.692
2012 Raskatov JA, Nickols NG, Hargrove AE, Marinov GK, Wold B, Dervan PB. Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proceedings of the National Academy of Sciences of the United States of America. 109: 16041-5. PMID 22988074 DOI: 10.1073/Pnas.1214267109  0.759
2012 Hargrove AE, Raskatov JA, Meier JL, Montgomery DC, Dervan PB. Characterization and solubilization of pyrrole-imidazole polyamide aggregates. Journal of Medicinal Chemistry. 55: 5425-32. PMID 22607187 DOI: 10.1021/Jm300380A  0.726
2012 Raskatov JA, Hargrove AE, So AY, Dervan PB. Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. Journal of the American Chemical Society. 134: 7995-9. PMID 22509786 DOI: 10.1021/Ja302588V  0.694
2011 Hargrove AE, Nieto S, Zhang T, Sessler JL, Anslyn EV. Artificial receptors for the recognition of phosphorylated molecules. Chemical Reviews. 111: 6603-782. PMID 21910402 DOI: 10.1021/Cr100242S  0.672
2011 Hargrove AE, Ellington AD, Anslyn EV, Sessler JL. Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides. Bioconjugate Chemistry. 22: 388-96. PMID 21299200 DOI: 10.1021/Bc100376X  0.592
2010 Hargrove AE, Reyes RN, Riddington I, Anslyn EV, Sessler JL. Boronic acid porphyrin receptor for ginsenoside sensing Organic Letters. 12: 4804-4807. PMID 20860384 DOI: 10.1021/Ol1019647  0.575
2010 Hargrove AE, Zhong Z, Sessler JL, Anslyn EV. Algorithms for the determination of binding constants and enantiomeric excess in complex host : guest equilibria using optical measurements. New Journal of Chemistry = Nouveau Journal De Chimie. 34: 348-354. PMID 20539751 DOI: 10.1039/B9Nj00498J  0.565
2010 Hargrove AE, Zhong Z, Sessler JL, Anslyn EV. Algorithms for the determination of binding constants and enantiomeric excess in complex host: Guest equilibria using optical measurements New Journal of Chemistry. 34: 348-354. DOI: 10.1039/b9nj00498j  0.495
2009 Collins BE, Sorey S, Hargrove AE, Shabbir SH, Lynch VM, Anslyn EV. Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids. The Journal of Organic Chemistry. 74: 4055-60. PMID 19391608 DOI: 10.1021/Jo900187A  0.455
2009 Collins BE, Sorey S, Hargrove AE, Shabbir SH, Lynch VM, Anslyn EV. Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids Journal of Organic Chemistry. 74: 4055-4060. DOI: 10.1021/jo900187a  0.39
2007 Pikulski M, Hargrove A, Shabbir SH, Anslyn EV, Brodbelt JS. Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap. Journal of the American Society For Mass Spectrometry. 18: 2094-106. PMID 17936010 DOI: 10.1016/J.Jasms.2007.09.005  0.473
2006 Sessler JL, Lee JT, Ou Z, Köhler T, Hargrove AE, Cho W, Lynch V, Kadish KM. Chemical and electrochemical oxidation of N-alkyl cyclo[n]pyrroles Journal of Porphyrins and Phthalocyanines. 10: 1329-1336. DOI: 10.1142/S1088424606000703  0.631
Show low-probability matches.