Sean M. O'Shea, Ph.D. - Related publications

2000 University of Chicago, Chicago, IL 
Neuroscience Biology, Molecular Biology, Biochemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. GABA receptor signalling mechanisms revealed by structural pharmacology. Nature. PMID 30602790 DOI: 10.1038/s41586-018-0832-5   
2019 Payghan PV, Nath Roy S, Bhattacharyya D, Ghoshal N. Cross-talk between allosteric and orthosteric binding sites of γ-amino butyric acid type A receptors (GABA-Rs): A computational study revealing the structural basis of selectivity. Journal of Biomolecular Structure & Dynamics. 1-16. PMID 30608219 DOI: 10.1080/07391102.2018.1508367   
2019 Absalom NL, Ahring PK, Liao VM, Balle T, Jiang T, Anderson LL, Arnold JC, McGregor IS, Bowen MT, Chebib M. Functional genomics of epilepsy-associated mutations in the GABA receptor subunits reveal that one mutation impairs function and two are catastrophic. The Journal of Biological Chemistry. PMID 30728247 DOI: 10.1074/jbc.RA118.005697   
2019 Celotto L, Eroli F, Nistri A, Vilotti S. Long-term application of cannabinoids leads to dissociation between changes in cAMP and modulation of GABA receptors of mouse trigeminal sensory neurons. Neurochemistry International. PMID 30633953 DOI: 10.1016/j.neuint.2019.01.007   
2019 Yamaguchi N, Mimura K, Okada S. GABA receptors in the hypothalamic paraventricular nucleus mediate β-adrenoceptor-induced elevations of plasma noradrenaline in rats. European Journal of Pharmacology. PMID 30685430 DOI: 10.1016/j.ejphar.2019.01.029   
2019 Winkler P, Luhmann HJ, Kilb W. Taurine potentiates the anticonvulsive effect of the GABA agonist muscimol and pentobarbital in the immature mouse hippocampus. Epilepsia. PMID 30682212 DOI: 10.1111/epi.14651   
2019 Vasović D, Divović B, Treven M, Knutson DE, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook JM, Savić MM. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of α6 GABA receptors. European Journal of Pain (London, England). PMID 30633839 DOI: 10.1002/ejp.1365   
2019 Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA. Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy. The Journal of Physiology. PMID 30604514 DOI: 10.1113/JP277292   
2019 Bledsoe D, Vacca B, Laube B, Klein BG, Costa B. Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors. European Journal of Pharmacology. 844: 216-224. PMID 30553788 DOI: 10.1016/j.ejphar.2018.12.023   
2019 Chandler CM, Reeves-Darby J, Jones SA, McDonald JA, Li G, Rahman MT, Cook JM, Platt DM. α5GABA subunit-containing receptors and sweetened alcohol cue-induced reinstatement and active sweetened alcohol self-administration in male rats. Psychopharmacology. PMID 30637435 DOI: 10.1007/s00213-018-5163-6   
2019 Szabo A, Nourmahnad A, Halpin E, Forman SA. Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant α1β3γ2L GABAA Receptors Indicates Selectivity and Cross-Talk Among Intersubunit Transmembrane Anesthetic Sites. Molecular Pharmacology. PMID 30696720 DOI: 10.1124/mol.118.115048   
2019 Sleno R, Hébert TE. Shaky ground - The nature of metastable GPCR signalling complexes. Neuropharmacology. PMID 30659839 DOI: 10.1016/j.neuropharm.2019.01.018   
2019 Mazzaferro S, Bermudez I, Sine SM. Potentiation of a neuronal nicotinic receptor via pseudo-agonist site. Cellular and Molecular Life Sciences : Cmls. PMID 30600358 DOI: 10.1007/s00018-018-2993-7   
2019 Gu S, Matta JA, Davini WB, Dawe GB, Lord B, Bredt DS. α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components. Cell Reports. 26: 866-874.e3. PMID 30673609 DOI: 10.1016/j.celrep.2018.12.103   
2019 Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H. Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins. Neuron. PMID 30704910 DOI: 10.1016/j.neuron.2019.01.001   
2019 Barua S, Kim JY, Kim JY, Kim JH, Lee JE. Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors. Neurochemical Research. PMID 30610652 DOI: 10.1007/s11064-018-02712-1   
2019 Bringeland GH, Bader L, Blaser N, Budzinski L, Schulz AR, Mei HE, Myhr KM, Vedeler CA, Gavasso S. Optimization of Receptor Occupancy Assays in Mass Cytometry: Standardization across Channels with QSC Beads. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. PMID 30688025 DOI: 10.1002/cyto.a.23723   
2019 Shoaib RM, Zhang JY, Mao XF, Wang YX. Gelsemine and koumine, principal active ingredients of Gelsemium, exhibit mechanical antiallodynia via spinal glycine receptor activation-induced allopregnanolone biosynthesis. Biochemical Pharmacology. 161: 136-148. PMID 30668937 DOI: 10.1016/j.bcp.2019.01.014   
2019 Wang JH, Nie WH, Shao XX, Li HZ, Hu MJ, Liu YL, Xu ZG, Guo ZY. Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay. Biochimica Et Biophysica Acta. Biomembranes. PMID 30684458 DOI: 10.1016/j.bbamem.2019.01.010   
2019 Wright SC, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin CF, Slodkowicz G, Marti-Solano M, Rodríguez D, Hot B, Okashah N, Strakova K, Valnohova J, Babu MM, Lambert NA, Carlsson J, et al. A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. Nature Communications. 10: 667. PMID 30737406 DOI: 10.1038/s41467-019-08630-2   
2019 Degovics D, Hartmann P, Németh IB, Árva-Nagy N, Kaszonyi E, Szél E, Strifler G, Bende B, Krenács L, Kemény L, Erős G. A novel target for the promotion of dermal wound healing: Ryanodine receptors. Toxicology and Applied Pharmacology. 366: 17-24. PMID 30684528 DOI: 10.1016/j.taap.2019.01.021   
2019 Kolb H, Barret O, Bhattacharya A, Chen G, Constantinescu C, Huang C, Letavic M, Tamagnan G, Xia C, Zhang W, Szardenings AK. Preclinical evaluation and non-human primate receptor occupancy study of F-JNJ-64413739, a novel PET radioligand for P2X7 receptors. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 30733317 DOI: 10.2967/jnumed.118.212696   
2019 Cooper SL, Soave M, Jörg M, Scammells PJ, Woolard J, Hill SJ. Probe dependence of allosteric enhancers on the binding affinity of adenosine A -receptor agonists at rat and human A -receptors measured using NanoBRET. British Journal of Pharmacology. PMID 30644086 DOI: 10.1111/bph.14575   
2019 Aldrin-Kirk P, Björklund T. Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain. Methods in Molecular Biology (Clifton, N.J.). 1937: 59-87. PMID 30706390 DOI: 10.1007/978-1-4939-9065-8_4   
2019 Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, Okazaki T. Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation. The Journal of Biological Chemistry. PMID 30760527 DOI: 10.1074/jbc.RA119.007455   
2019 Ma L, Nelson ER. Oxysterols and nuclear receptors. Molecular and Cellular Endocrinology. PMID 30660701 DOI: 10.1016/j.mce.2019.01.016   
2019 Nayak TK, Vij R, Bruhova I, Shandilya J, Auerbach A. Efficiency measures the conversion of agonist binding energy into receptor conformational change. The Journal of General Physiology. PMID 30635369 DOI: 10.1085/jgp.201812215   
2019 Torcato IM, Kasal MR, Brito PH, Miller ST, Xavier KB. Identification of novel autoinducer-2 receptors in Clostridia reveals plasticity in the binding site of the LsrB receptor family. The Journal of Biological Chemistry. PMID 30696769 DOI: 10.1074/jbc.RA118.006938   
2019 Igawa T, Kishikawa S, Abe Y, Yamashita T, Nagai S, Shiroishi M, Shinozaki C, Tanaka H, Tozaki-Saitoh H, Tsuda M, Inoue K, Ueda T. Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure. Purinergic Signalling. PMID 30684150 DOI: 10.1007/s11302-019-09646-5   
2019 Manilall A, Stander BA, Madziva MT, Millar RP, Flanagan CA. Glu of the GnRH receptor is part of the conserved G protein-coupled receptor structure and does not form a salt-bridge with Lys. Molecular and Cellular Endocrinology. 481: 53-61. PMID 30476558 DOI: 10.1016/j.mce.2018.11.009   
2019 Wu SF, Jv XM, Huang JM, Gao CF. Molecular features and expression profiles of octopamine receptors in the brown planthopper, Nilaparvata lugens. Pest Management Science. PMID 30734475 DOI: 10.1002/ps.5371   
2019 Wang Q, Zhou FM. cAMP-producing chemogenetic and adenosine A2a receptor activation inhibits the inwardly rectifying potassium current in striatal projection neurons. Neuropharmacology. PMID 30659840 DOI: 10.1016/j.neuropharm.2019.01.014   
2019 Avila-Luna A, Ríos C, Gálvez-Rosas A, Montes S, Arias-Montaño JA, Bueno-Nava A. Chronic administration of the histamine H receptor agonist immepip decreases L-Dopa-induced dyskinesias in 6-hydroxydopamine-lesioned rats. Psychopharmacology. PMID 30762089 DOI: 10.1007/s00213-019-5182-y   
2019 Marucci G, Dal Ben D, Lambertucci C, Martí Navia A, Spinaci A, Volpini R, Buccioni M. GPR17 receptor modulators and their therapeutic implications: review of recent patents. Expert Opinion On Therapeutic Patents. 29: 85-95. PMID 30640576 DOI: 10.1080/13543776.2019.1568990   
2019 Härter M, Kalthof B, Delbeck M, Lustig K, Gerisch M, Schulz S, Kast R, Meibom D, Lindner N. Novel non-xanthine antagonist of the A adenosine receptor: From HTS hit to lead structure. European Journal of Medicinal Chemistry. 163: 763-778. PMID 30576906 DOI: 10.1016/j.ejmech.2018.11.045   
2019 Salehi S, Moayedian NS, Alarcon E. Diffusion-based Molecular Communication Channel in Presence of a Probabilistic Absorber: Single Receptor Model and Congestion Analysis. Ieee Transactions On Nanobioscience. PMID 30624222 DOI: 10.1109/TNB.2019.2891238   
2019 Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL. Toreforant, an orally active histamine H-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. PMID 30739130 DOI: 10.1007/s00011-019-01218-y   
2019 Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. PMID 30639100 DOI: 10.1016/j.cell.2018.12.006   
2019 Yim YY, Betke KM, McDonald WH, Gilsbach R, Chen Y, Hyde K, Wang Q, Hein L, Hamm H. The in vivo specificity of synaptic Gβ and Gγ subunits to the α adrenergic receptor at CNS synapses. Scientific Reports. 9: 1718. PMID 30737458 DOI: 10.1038/s41598-018-37222-1   
2019 Neale JH, Olszewski R. A role for N-acetylaspartylglutamate (NAAG) and mGluR3 in cognition. Neurobiology of Learning and Memory. 158: 9-13. PMID 30630041 DOI: 10.1016/j.nlm.2019.01.006   
2019 Do HB, Ohbuchi T, Yokoyama M, Kitamura T, Wakasugi T, Ohkubo JI, Suzuki H. Decreased ciliary beat responsiveness to acetylcholine in the nasal polyp epithelium. Clinical Otolaryngology : Official Journal of Ent-Uk ; Official Journal of Netherlands Society For Oto-Rhino-Laryngology & Cervico-Facial Surgery. PMID 30762948 DOI: 10.1111/coa.13312   
2019 Leaton LA, Shortt J, Kichula KM, Tao S, Nemat-Gorgani N, Mentzer AJ, Oppenheimer SJ, Deng Z, Hollenbach JA, Gignoux CR, Guethlein LA, Parham P, Carrington M, Norman PJ. Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates. Frontiers in Immunology. 10: 24. PMID 30745901 DOI: 10.3389/fimmu.2019.00024   
2019 Zhang L, Luo B, Dang YW, He RQ, Chen G, Peng ZG, Feng ZB. The clinical significance of endothelin receptor type B in hepatocellular carcinoma and its potential molecular mechanism. Experimental and Molecular Pathology. PMID 30768923 DOI: 10.1016/j.yexmp.2019.02.002   
2019 Pandey P, Roy KK, Doerksen RJ. Negative Allosteric Modulators of Cannabinoid Receptor 2: Protein Modeling, Binding Site Identification and Molecular Dynamics Simulations in the Presence of an Orthosteric Agonist. Journal of Biomolecular Structure & Dynamics. 1-23. PMID 30652534 DOI: 10.1080/07391102.2019.1567384   
2019 Lenaerts C, Marchal E, Peeters P, Vanden Broeck J. The ecdysone receptor complex is essential for the reproductive success in the female desert locust, Schistocerca gregaria. Scientific Reports. 9: 15. PMID 30626886 DOI: 10.1038/s41598-018-36763-9   
2019 Cloutier G, Sallenbach-Morrissette A, Beaulieu JF. Non-integrin laminin receptors in epithelia. Tissue & Cell. 56: 71-78. PMID 30736907 DOI: 10.1016/j.tice.2018.12.005   
2019 Chitranshi N, Dheer Y, Kumar S, Graham SL, Gupta V. Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand-activated transcription factors, retinoid X receptors. Journal of Cellular Biochemistry. PMID 30746761 DOI: 10.1002/jcb.28455   
2019 Michael JV, Gavrila A, Nayak AP, Pera T, Liberato JR, Polischak SR, Shah SD, Deshpande DA, Penn RB. Cooperativity of E-prostanoid receptor subtypes in regulating signaling and growth inhibition in human airway smooth muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801959R. PMID 30601680 DOI: 10.1096/fj.201801959R   
2019 Nagarajan S, Alkayed NJ, Kaul S, Barnes AP. Effect of Thermostable Mutations on the Neurotensin Receptor 1 (NTSR1) Activation State. Journal of Biomolecular Structure & Dynamics. 1-17. PMID 30706767 DOI: 10.1080/07391102.2019.1573705   
2019 Vecchio EA, White PJ, May LT. The Adenosine AG Protein-Coupled Receptor: Recent Advances and Therapeutic Implications. Pharmacology & Therapeutics. PMID 30677476 DOI: 10.1016/j.pharmthera.2019.01.003