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Goldis Malek, Ph.D. - Publications

Affiliations: 
2002 University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Ophthalmology, Anatomy Biology
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Malek G. Location of retinal pigment epithelial cells in the eye is critical to their function. The American Journal of Pathology. PMID 37160188 DOI: 10.1016/j.ajpath.2023.04.005  0.326
2023 Choudhary M, Tayyari F, Handa JT, Malek G. Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies. Laboratory Investigation; a Journal of Technical Methods and Pathology. 102: 1132-1142. PMID 36775353 DOI: 10.1038/s41374-022-00795-7  0.433
2022 Choudhary M, Malek G. Potential therapeutic targets for age-related macular degeneration: The nuclear option. Progress in Retinal and Eye Research. 101130. PMID 36220751 DOI: 10.1016/j.preteyeres.2022.101130  0.415
2022 Malek G, Campisi J, Kitazawa K, Webster C, Lakkaraju A, Skowronska-Krawczyk D. Does senescence play a role in age-related macular degeneration? Experimental Eye Research. 109254. PMID 36150544 DOI: 10.1016/j.exer.2022.109254  0.39
2022 Peavey J, Parmar VM, Malek G. Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration. Cells. 11. PMID 35954227 DOI: 10.3390/cells11152386  0.376
2022 Yao PL, Parmar VM, Choudhary M, Malek G. NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 119: e2202256119. PMID 35867766 DOI: 10.1073/pnas.2202256119  0.448
2022 Bharti K, den Hollander AI, Lakkaraju A, Sinha D, Williams DS, Finnemann SC, Bowes-Rickman C, Malek G, D'Amore PA. Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration. Experimental Eye Research. 222: 109170. PMID 35835183 DOI: 10.1016/j.exer.2022.109170  0.385
2022 Csaky K, Curcio CA, Mullins RF, Rosenfeld PJ, Fujimoto J, Rohrer B, Ribero R, Malek G, Waheed N, Guymer R, Hageman GS, Chen H, Csete M. New approaches to the treatment of Age-Related Macular Degeneration (AMD). Experimental Eye Research. 221: 109134. PMID 35654115 DOI: 10.1016/j.exer.2022.109134  0.47
2022 Choudhary M, Tayyari F, Handa JT, Malek G. Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 35589984 DOI: 10.1038/s41374-022-00795-7  0.433
2022 Choudhary M, Ildefonso CJ, Lewin AS, Malek G. Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 35446130 DOI: 10.1089/jop.2022.0002  0.326
2021 Pilgrim MG, Marouf S, Fearn S, Csincsik L, Kortvely E, Knowles JC, Malek G, Thompson RB, Lengyel I. Characterization of Calcium Phosphate Spherical Particles in the Subretinal Pigment Epithelium-Basal Lamina Space in Aged Human Eyes. Ophthalmology Science. 1: 100053. PMID 36247811 DOI: 10.1016/j.xops.2021.100053  0.387
2021 Lekwuwa M, Choudhary M, Lad EM, Malek G. Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 34389792 DOI: 10.1038/s41379-021-00887-7  0.444
2020 Hadziahmetovic M, Malek G. Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies. Frontiers in Cell and Developmental Biology. 8: 612812. PMID 33569380 DOI: 10.3389/fcell.2020.612812  0.354
2020 Choudhary M, Malek G. The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases. International Journal of Molecular Sciences. 21. PMID 32947781 DOI: 10.3390/Ijms21186777  0.358
2020 Yao PL, Peavey J, Malek G. Leveraging Nuclear Receptors as Targets for Pathological Ocular Vascular Diseases. International Journal of Molecular Sciences. 21. PMID 32326149 DOI: 10.3390/Ijms21082889  0.39
2019 Choudhary M, Malek G. A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a Focus on Potential Endpoints for Testing Therapeutic Interventions in Preclinical Studies. Advances in Experimental Medicine and Biology. 1185: 9-13. PMID 31884581 DOI: 10.1007/978-3-030-27378-1_2  0.454
2019 Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G. LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. Jci Insight. PMID 31829999 DOI: 10.1172/Jci.Insight.131928  0.53
2018 Ban N, Lee TJ, Sene A, Choudhary M, Lekwuwa M, Dong Z, Santeford A, Lin JB, Malek G, Ory DS, Apte RS. Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. Jci Insight. 3. PMID 30185655 DOI: 10.1172/Jci.Insight.120824  0.499
2018 Choudhary M, Safe S, Malek G. Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor. Biochimica Et Biophysica Acta. PMID 29481912 DOI: 10.1016/J.Bbadis.2018.02.015  0.426
2018 Malek G, Busik J, Grant MB, Choudhary M. Models of retinal diseases and their applicability in drug discovery. Expert Opinion On Drug Discovery. 1-19. PMID 29382242 DOI: 10.1080/17460441.2018.1430136  0.401
2017 Hammer SS, Beli E, Kady N, Wang Q, Wood K, Lydic TA, Malek G, Saban DR, Wang XX, Hazra S, Levi M, Busik JV, Grant MB. The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. Ebiomedicine. PMID 28774737 DOI: 10.1016/J.Ebiom.2017.07.008  0.334
2017 Ismail EN, Ruberti JW, Malek G. Quick-freeze/deep-etch electron microscopy visualization of the mouse posterior pole. Experimental Eye Research. PMID 28629927 DOI: 10.1016/J.Exer.2017.06.013  0.41
2016 Choudhary M, Ding JD, Qi X, Boulton ME, Yao PL, Peters JM, Malek G. PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration. Aging. PMID 27622388 DOI: 10.18632/aging.101031  0.416
2016 Choudhary M, Malek G. Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases. Journal of Biomolecular Screening. PMID 27455994 DOI: 10.1177/1087057116659856  0.472
2016 Choudhary M, Malek G. A Brief Discussion on Lipid Activated Nuclear Receptors and their Potential Role in Regulating Microglia in Age-Related Macular Degeneration (AMD). Advances in Experimental Medicine and Biology. 854: 45-51. PMID 26427392 DOI: 10.1007/978-3-319-17121-0_7  0.485
2015 Choudhary M, Kazmin D, Hu P, Thomas RS, McDonnell DP, Malek G. Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways. The Journal of Pathology. 235: 101-12. PMID 25186463 DOI: 10.1002/Path.4433  0.442
2014 Malek G, Lad EM. Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration. Cellular and Molecular Life Sciences : Cmls. 71: 4617-36. PMID 25156067 DOI: 10.1007/S00018-014-1709-X  0.46
2014 Malek G. Nuclear receptors as potential therapeutic targets for age-related macular degeneration. Advances in Experimental Medicine and Biology. 801: 317-21. PMID 24664713 DOI: 10.1007/978-1-4614-3209-8_40  0.436
2013 Espinosa-Heidmann DG, Malek G, Mettu PS, Caicedo A, Saloupis P, Gach S, Dunnon AK, Hu P, Spiga MG, Cousins SW. Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization. Investigative Ophthalmology & Visual Science. 54: 7439-49. PMID 24135751 DOI: 10.1167/Iovs.13-12546  0.328
2013 Hu P, Herrmann R, Bednar A, Saloupis P, Dwyer MA, Yang P, Qi X, Thomas RS, Jaffe GJ, Boulton ME, McDonnell DP, Malek G. Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proceedings of the National Academy of Sciences of the United States of America. 110: E4069-78. PMID 24106308 DOI: 10.1073/Pnas.1307574110  0.516
2012 Malek G, Dwyer M, McDonnell D. Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD Advances in Experimental Medicine and Biology. 723: 51-59. PMID 22183315 DOI: 10.1007/978-1-4614-0631-0_8  0.34
2011 Dwyer MA, Kazmin D, Hu P, McDonnell DP, Malek G. Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration. Molecular Endocrinology (Baltimore, Md.). 25: 360-72. PMID 21239617 DOI: 10.1210/Me.2010-0392  0.449
2010 Malek G, Hu P, Wielgus A, Dwyer M, Cousins S. PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration. Advances in Experimental Medicine and Biology. 664: 429-36. PMID 20238044 DOI: 10.1007/978-1-4419-1399-9_49  0.454
2010 Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Progress in Retinal and Eye Research. 29: 95-112. PMID 19961953 DOI: 10.1016/J.Preteyeres.2009.11.003  0.439
2010 Zweifel SA, Spaide RF, Curcio CA, Malek G, Imamura Y. Reticular pseudodrusen are subretinal drusenoid deposits. Ophthalmology. 117: 303-12.e1. PMID 19815280 DOI: 10.1016/J.Ophtha.2009.07.014  0.563
2008 Rudolf M, Malek G, Messinger JD, Clark ME, Wang L, Curcio CA. Sub-retinal drusenoid deposits in human retina: organization and composition. Experimental Eye Research. 87: 402-8. PMID 18721807 DOI: 10.1016/J.Exer.2008.07.010  0.598
2008 Baer CA, Rickman CB, Srivastava S, Malek G, Stinnett S, Toth CA. Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomy. Retina (Philadelphia, Pa.). 28: 1221-7. PMID 18626416 DOI: 10.1097/Iae.0B013E31817D5Bce  0.401
2008 Malek G, Jamison JA, Mace B, Sullivan P, Rickman CB. ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. Advances in Experimental Medicine and Biology. 613: 165-70. PMID 18188941 DOI: 10.1007/978-0-387-74904-4_18  0.415
2007 Edwards AO, Malek G. Molecular genetics of AMD and current animal models. Angiogenesis. 10: 119-32. PMID 17372852 DOI: 10.1007/S10456-007-9064-2  0.364
2006 Malek G, Mace B, Saloupis P, Schmechel D, Rickman D, Sullivan P, Rickman CB. Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice. Advances in Experimental Medicine and Biology. 572: 109-17. PMID 17249563 DOI: 10.1007/0-387-32442-9_17  0.373
2005 Rosenthal R, Malek G, Salomon N, Peill-Meininghaus M, Coeppicus L, Wohlleben H, Wimmers S, Bowes Rickman C, Strauss O. The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. Biochemical and Biophysical Research Communications. 337: 241-7. PMID 16188231 DOI: 10.1016/J.Bbrc.2005.09.028  0.347
2005 Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C. Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 11900-5. PMID 16079201 DOI: 10.1016/J.Ajo.2006.01.010  0.507
2005 Curcio CA, Presley JB, Malek G, Medeiros NE, Avery DV, Kruth HS. Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy. Experimental Eye Research. 81: 731-41. PMID 16005869 DOI: 10.1016/J.Exer.2005.04.012  0.564
2005 Li CM, Chung BH, Presley JB, Malek G, Zhang X, Dashti N, Li L, Chen J, Bradley K, Kruth HS, Curcio CA. Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization. Investigative Ophthalmology & Visual Science. 46: 2576-86. PMID 15980251 DOI: 10.1167/Iovs.05-0034  0.486
2004 Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Rickman CB, Strauss O. Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration Biochemical and Biophysical Research Communications. 323: 1203-1208. PMID 15451424 DOI: 10.1016/J.Bbrc.2004.08.219  0.348
2003 Malek G, Li CM, Guidry C, Medeiros NE, Curcio CA. Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy. The American Journal of Pathology. 162: 413-25. PMID 12547700 DOI: 10.1016/S0002-9440(10)63836-9  0.545
2000 Milam AH, Curcio CA, Cideciyan AV, Saxena S, John SK, Kruth HS, Malek G, Heckenlively JR, Weleber RG, Jacobson SG. Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration. Ophthalmology. 107: 2256-66. PMID 11097607 DOI: 10.1016/S0161-6420(00)00419-X  0.578
2000 Curcio CA, Saunders PL, Younger PW, Malek G. Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss. Ophthalmology. 107: 334-43. PMID 10690836 DOI: 10.1016/S0161-6420(99)00037-8  0.543
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