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Luis G. Cuello, Ph.D. - Publications

Affiliations: 
2005 University of Virginia, Charlottesville, VA 
Area:
General Biophysics, Animal Physiology Biology
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74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ullah G, Nosyreva ED, Thompson D, Cuello V, Cuello LG, Syeda R. Analysis of pressure activated Piezo1 open and subconductance states at a single channel level. The Journal of Biological Chemistry. 107156. PMID 38479601 DOI: 10.1016/j.jbc.2024.107156  0.387
2022 Coonen L, Martinez-Morales E, Van De Sande DV, Snyders DJ, Cortes DM, Cuello LG, Labro AJ. The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels. Science Advances. 8: eabn1731. PMID 36112676 DOI: 10.1126/sciadv.abn1731  0.472
2020 Lewis A, McCrossan ZA, Manville RW, Popa MO, Cuello LG, Goldstein SAN. TOK channels use the two gates in classical K channels to achieve outward rectification. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32519783 DOI: 10.1096/Fj.202000545R  0.595
2020 Coonen L, Mayeur E, De Neuter N, Snyders DJ, Cuello LG, Labro AJ. The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophysical Journal. PMID 32365329 DOI: 10.1016/J.Bpj.2020.03.032  0.602
2020 Cortes DM, Cuello LG. Halting KcsA'S C-Type Inactivation Gating by Controlling Water Diffusion Behind the Channel'S Selectivity Filter Biophysical Journal. 118: 260a. DOI: 10.1016/J.Bpj.2019.11.1509  0.488
2020 Baenziger JE, Henault CM, Govaerts C, Estrada A, Lynch J, Bertrand D, Pardon E, Evans G, Woods KN, Elberson BW, Cuello LG, Brannigan GH, Nury H, Steyaert J, Ulens C. A Lipid Recognition Site at a Transmembrane Helix Kink Shapes the Agonist Response of a Pentameric Ligand-gated Ion Channel Biophysical Journal. 118: 191a. DOI: 10.1016/J.Bpj.2019.11.1156  0.534
2019 Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, et al. A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nature Chemical Biology. PMID 31591563 DOI: 10.1038/S41589-019-0369-4  0.512
2019 Tilegenova C, Cortes DM, Jahovic N, Hardy E, Hariharan P, Guan L, Cuello LG. Structure, function, and ion-binding properties of a K channel stabilized in the 2,4-ion-bound configuration. Proceedings of the National Academy of Sciences of the United States of America. PMID 31387976 DOI: 10.1073/Pnas.1901888116  0.55
2019 Cuello LG. Decision letter: Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175 Elife. DOI: 10.7554/Elife.53430.Sa1  0.522
2019 Tilegenova C, Cortes DM, Jahovic N, Hardy E, Hariharan P, Guan L, Cuello LG. Trapping the 2,4-K+-Ion Bound Configuration of KcsA's Selectivity Filter Biophysical Journal. 116: 103a. DOI: 10.1016/J.Bpj.2018.11.593  0.402
2018 Li J, Ostmeyer J, Cuello LG, Perozo E, Roux B. Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel. The Journal of General Physiology. PMID 30072373 DOI: 10.1085/Jgp.201812082  0.762
2018 Labro AJ, Cortes DM, Tilegenova C, Cuello LG. Inverted allosteric coupling between activation and inactivation gates in K channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735651 DOI: 10.1073/Pnas.1800559115  0.676
2018 Tilegenova C, Cortes DM, Cuello LG. Revisiting the Role of Glycine 77 within KcsA'S Selectivity Filter: A Functional and Crystallographic Study Biophysical Journal. 114: 546a. DOI: 10.1016/J.Bpj.2017.11.2984  0.346
2017 Fiori MC, Krishnan S, Kjellgren A, Cuello LG, Altenberg GA. Inhibition by Commercial Aminoglycosides of Human Connexin Hemichannels Expressed in Bacteria. Molecules (Basel, Switzerland). 22. PMID 29186829 DOI: 10.3390/Molecules22122063  0.307
2017 Cuello LG, Cortes DM, Perozo E. The gating cycle of a K(+) channel at atomic resolution. Elife. 6. PMID 29165243 DOI: 10.7554/Elife.28032  0.742
2017 Rosholm KR, Baker MA, Ridone P, Nakayama Y, Rohde PR, Cuello LG, Lee LK, Martinac B. Activation of the mechanosensitive ion channel MscL by mechanical stimulation of supported Droplet-Hydrogel bilayers. Scientific Reports. 7: 45180. PMID 28345591 DOI: 10.1038/Srep45180  0.559
2017 Elberson BW, Whisenant TE, Cortes DM, Cuello LG. A cost-effective protocol for the over-expression and purification of fully-functional and more stable Erwinia chrysanthemi ligand-gated ion channel. Protein Expression and Purification. 133: 177-186. PMID 28279818 DOI: 10.1016/J.Pep.2017.03.006  0.567
2017 Tilegenova C, Cortes DM, Cuello LG. Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 114: 3234-3239. PMID 28265056 DOI: 10.1073/Pnas.1618101114  0.607
2017 Cuello LG, Cortes DM, Perozo E. Author response: The gating cycle of a K+ channel at atomic resolution Elife. DOI: 10.7554/Elife.28032.016  0.678
2017 Zhao R, Dai H, Mendelman N, Cuello LG, Chill JH, Goldstein SA. Identification of Novel and Natural High Affinity Peptide Inhibitors of KcsA by Phage-Display Reveals an Unexpected Mechanism of Pore Blockade Biophysical Journal. 112: 173a. DOI: 10.1016/J.Bpj.2016.11.956  0.593
2017 Elberson BW, Whisenant TE, Cortes DM, Cuello LG. Biochemical and Thermodynamic Characterization of the Erwinia Chrysanthemi Ligand-Gated Ion Channel Biophysical Journal. 112: 553a. DOI: 10.1016/J.Bpj.2016.11.2986  0.562
2017 Whisenant TE, Elberson BW, Cortes DM, Cuello LG. Thermoanalytical Characterization of Pentameric Elic Based on Detergent Size Biophysical Journal. 112: 553a. DOI: 10.1016/J.Bpj.2016.11.2985  0.476
2017 Tilegenova C, Cortes DM, Cuello LG. The Activation Gate and the Selectivity Filter of KcsA are Tightly Coupled Biophysical Journal. 112: 247a. DOI: 10.1016/J.Bpj.2016.11.1352  0.425
2016 Krishnan S, Fiori MC, Whisenant TE, Cortes DM, Altenberg GA, Cuello LG. An Escherichia coli-Based Assay to Assess the Function of Recombinant Human Hemichannels. Journal of Biomolecular Screening. PMID 27789753 DOI: 10.1177/1087057116675321  0.343
2016 Tilegenova C, Vemulapally S, Cortes DM, Cuello LG. An improved method for the cost-effective expression and purification of large quantities of KcsA. Protein Expression and Purification. 127: 53-60. PMID 27393071 DOI: 10.1016/J.Pep.2016.07.002  0.572
2016 Tilegenova C, Vemulapally S, Cortes DM, Cuello LG. An improved method for the cost-effective expression and purification of large quantities of KcsA Protein Expression and Purification. 127: 53-60. DOI: 10.1016/j.pep.2016.07.002  0.489
2016 Krishnan S, Cortés DM, Altenberg GA, Cuello LG. A Novel E. Coli-Based Assay for Rapid Screening of Hemichannel Function Biophysical Journal. 110: 118a. DOI: 10.1016/J.Bpj.2015.11.687  0.337
2016 Vemulapally S, Cortes DM, Cuello LG. Functional and Crystallographic Studies of Hetero-Multimeric K+ Channels Biophysical Journal. 110: 344a. DOI: 10.1016/J.Bpj.2015.11.1852  0.633
2016 Tilegenova C, Cortes DM, Cuello LG. Elucidation of Molecular Mechanism Underlying KcsA's Hysteretic Gating Behavior Biophysical Journal. 110: 278a. DOI: 10.1016/J.Bpj.2015.11.1507  0.648
2015 Zhao R, Dai H, Mendelman N, Cuello LG, Chill JH, Goldstein SA. Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. Proceedings of the National Academy of Sciences of the United States of America. PMID 26627718 DOI: 10.1073/Pnas.1514728112  0.596
2015 Morera FJ, Saravia J, Pontigo JP, Vargas-Chacoff L, Contreras GF, Pupo A, Lorenzo Y, Castillo K, Tilegenova C, Cuello LG, Gonzalez C. Voltage-dependent BK and Hv1 channels expressed in non-excitable tissues: New therapeutics opportunities as targets in human diseases. Pharmacological Research. PMID 26305431 DOI: 10.1016/J.Phrs.2015.08.011  0.84
2015 Fiori MC, Krishnan S, Cortes DM, Retamal MA, Reuss L, Altenberg GA, Cuello LG. Functional hemichannels formed by human connexin 26 expressed in bacteria. Bioscience Reports. 35. PMID 25585383 DOI: 10.1042/Bsr20140089  0.382
2015 Cuello LG, Cortes DM. Engineering hERG Channel Inner Cavity within KcsA Structure Biophysical Journal. 108: 120a. DOI: 10.1016/J.Bpj.2014.11.672  0.617
2015 Tilegenova C, Cortes DM, Cuello LG. The Conformation of KcsA's Selectivity Filter Influences the Opening of its Activation Gate Biophysical Journal. 108: 120a. DOI: 10.1016/J.Bpj.2014.11.671  0.664
2014 Fiori MC, Reuss L, Cuello LG, Altenberg GA. Functional analysis and regulation of purified connexin hemichannels. Frontiers in Physiology. 5: 71. PMID 24611052 DOI: 10.3389/Fphys.2014.00071  0.394
2014 Randich AM, Cuello LG, Wanderling SS, Perozo E. Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVP. Biochemistry. 53: 1627-36. PMID 24490868 DOI: 10.1021/Bi4014243  0.843
2014 Fiori M, Cortes MD, Retamal MA, Krishnan S, Reuss L, Altenberg GA, Cuello LG. Purified Functional Human Connexin 26 Hemichannels Expressed in E. Coli Biophysical Journal. 106: 761a. DOI: 10.1016/J.Bpj.2013.11.4189  0.416
2014 Velez BA, Cortes DM, Cuello LG. Role Played by the Glutamate 71 and Aspartate 80 Carboxyl-Carboxylate Interaction in KCSA C-Type Inactivation Gating Biophysical Journal. 106: 540a. DOI: 10.1016/J.Bpj.2013.11.3009  0.553
2014 Cuello LG, Cortes DM, Perozo E. A Structural Driven Kinetic Cycle for KcsA Gating Biophysical Journal. 106: 16a. DOI: 10.1016/J.Bpj.2013.11.140  0.676
2013 Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C. Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 110: 18716-21. PMID 24167270 DOI: 10.1073/Pnas.1313156110  0.621
2013 Cortes DM, Cuello LG. A KcsA-hERG Chimera Provides Structural Insights into the Unusual hERG Inactivation Gating Mechanism Biophysical Journal. 104: 122a. DOI: 10.1016/J.Bpj.2012.11.704  0.672
2013 Cortes DM, Labro AJ, Cuello LG. Structural and Functional Consequences of Replacing Glycine 77 with a L-Alanine at the KcsA Selectivity Filter Biophysical Journal. 104: 466a. DOI: 10.1016/J.Bpj.2012.11.2578  0.529
2012 Cuello LG, Cortes DM, Perozo E. Role of Structural Water in the Stabilization of the KcsA C-Type Inactivated Selectivity Filter: Evidence from High-Resolution Structures Biophysical Journal. 102: 529a. DOI: 10.1016/J.Bpj.2011.11.2891  0.715
2012 Labro AJ, Cortes DM, Gagnon DG, Snyders DJ, Cuello LG. The Role of the 2nd Threonine Within the TTVGYGD Sequence of Kv-Channels in C-Type Inactivation Gating, Ion Selectivity and Permeation Biophysical Journal. 102: 13a. DOI: 10.1016/J.Bpj.2011.11.094  0.646
2011 Pan AC, Cuello LG, Perozo E, Roux B. Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations. The Journal of General Physiology. 138: 571-80. PMID 22124115 DOI: 10.1085/Jgp.201110670  0.77
2011 Uysal S, Cuello LG, Cortes DM, Koide S, Kossiakoff AA, Perozo E. Mechanism of activation gating in the full-length KcsA K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 11896-9. PMID 21730186 DOI: 10.1073/Pnas.1105112108  0.775
2011 Cuello LG, Gagnon DG, Cortes DM. The Second Highly-Conserved Threonine Residue of the Potassium Channel Signature Sequence Mediates Activation-Coupled to C-Type Inactivation Biophysical Journal. 100: 366a-367a. DOI: 10.1016/J.Bpj.2010.12.2189  0.624
2010 Dalmas O, Cuello LG, Jogini V, Cortes DM, Roux B, Perozo E. Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer. Structure (London, England : 1993). 18: 868-78. PMID 20637423 DOI: 10.1016/J.Str.2010.04.009  0.779
2010 Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature. 466: 272-5. PMID 20613845 DOI: 10.1038/Nature09136  0.828
2010 Cuello LG, Jogini V, Cortes DM, Perozo E. Structural mechanism of C-type inactivation in K(+) channels. Nature. 466: 203-8. PMID 20613835 DOI: 10.1038/Nature09153  0.855
2010 Cuello LG, Jogini V, Cortes DM, Sompornpisut A, Purdy MD, Wiener MC, Perozo E. Design and characterization of a constitutively open KcsA. Febs Letters. 584: 1133-8. PMID 20153331 DOI: 10.1016/J.Febslet.2010.02.015  0.805
2010 Cuello LG, Cortes DM, Jogini V, Sompornpisut A, Perozo E. A molecular mechanism for proton-dependent gating in KcsA. Febs Letters. 584: 1126-32. PMID 20138880 DOI: 10.1016/J.Febslet.2010.02.003  0.787
2010 Dalmas O, Sandtner W, Santos JS, Frezza L, Cuello LG, Bezanilla F, Perozo E. Analysis of CorA-Catalyzed Mg2+ Selective Currents in Xenopus Oocytes Biophysical Journal. 98: 705a. DOI: 10.1016/J.Bpj.2009.12.3869  0.784
2010 Pan AC, Chakrapani S, Jogini V, Cuello LG, Cortes DM, Perozo E, Roux B. The Importance of Ion Binding for Potassium Channel Inactivation and Recovery Biophysical Journal. 98: 621a. DOI: 10.1016/J.Bpj.2009.12.3400  0.844
2010 Cuello LG, Cortes DM, Perozo E. An Engineered Cysteine-Bridge Locks KcsA Inner Bundle Gate in Its Open Conformation Biophysical Journal. 98: 314a. DOI: 10.1016/J.Bpj.2009.12.1706  0.773
2010 Cuello LG, Cortes DM, Perozo E. High-Resolution Crystallographic Analysis of the Kcsa Gating Cycle from Cysteine-Trapped Open Channels Biophysical Journal. 98: 314a. DOI: 10.1016/J.Bpj.2009.12.1704  0.777
2009 Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA. A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proceedings of the National Academy of Sciences of the United States of America. 106: 22211-6. PMID 20007782 DOI: 10.1073/Pnas.0910123106  0.689
2009 Chakrapani S, Jogini V, Cuello LG, Cortes M, Perozo E. On the Structure-Function correlates of Ion Occupancy and modulation of C-type Inactivation Biophysical Journal. 96: 657a. DOI: 10.1016/J.Bpj.2008.12.3471  0.857
2009 Cuello LG, Chakrapani S, Cortes DM, Dalmas O, Perozo E. Influence Of The Kcsa C-terminal Domain In The Coupling Between Activation And Inactivation Gates Biophysical Journal. 96: 657a. DOI: 10.1016/J.Bpj.2008.12.3470  0.858
2009 Pan AC, Jogini V, Cuello LG, Cortes D, Perozo E, Roux B. Free Energy Landscape for the Inactivation of the KcsA Potassium Channel Biophysical Journal. 96: 657a. DOI: 10.1016/J.Bpj.2008.12.3469  0.842
2009 Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E. Structural Basis For The Coupling Between Activation And Inactivation Gating In Potassium Channels Biophysical Journal. 96: 381a. DOI: 10.1016/J.Bpj.2008.12.2852  0.849
2009 Uysal S, Cuello LG, Jogini V, Cortes DM, Koide S, Perozo E, Kossiakoff A. Crystal Structure Of Full-length Kcsa Trapped In Open Conformation Reveals That C-terminal Domain Fine Tunes Activation And Coupled Inactivation Biophysical Journal. 96: 370a. DOI: 10.1016/J.Bpj.2008.12.1994  0.809
2008 Chakrapani S, Cuello LG, Cortes DM, Perozo E. Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (London, England : 1993). 16: 398-409. PMID 18334215 DOI: 10.1016/J.Str.2007.12.015  0.775
2006 Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. The Journal of General Physiology. 128: 569-81. PMID 17043150 DOI: 10.1085/Jgp.200609638  0.851
2006 Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Roux B, Perozo E. Molecular determinants of gating at the potassium-channel selectivity filter. Nature Structural & Molecular Biology. 13: 311-8. PMID 16532009 DOI: 10.1038/Nsmb1069  0.856
2006 Cordero-Morales JF, Cuello LG, Perozo E. Voltage-dependent gating at the KcsA selectivity filter. Nature Structural & Molecular Biology. 13: 319-22. PMID 16532008 DOI: 10.1038/Nsmb1070  0.816
2005 Ptak CP, Cuello LG, Perozo E. Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces. Biochemistry. 44: 62-71. PMID 15628846 DOI: 10.1021/Bi048390F  0.789
2004 Cuello LG, Cortes DM, Perozo E. Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science (New York, N.Y.). 306: 491-5. PMID 15486302 DOI: 10.1126/Science.1101373  0.712
2002 Perozo E, Cuello LG, Cortes DM, Liu YS, Sompornpisut P. EPR approaches to ion channel structure and function. Novartis Foundation Symposium. 245: 146-58; discussion 1. PMID 12027005 DOI: 10.1002/0470868759.Ch10  0.821
2001 Cortes DM, Cuello LG, Perozo E. Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. The Journal of General Physiology. 117: 165-80. PMID 11158168 DOI: 10.1085/Jgp.117.2.165  0.691
2000 Perozo E, Liu Y, Cortes DM, Cuello LG. Structural Basis of Activation Gating in K+ Channels Biochemical Society Transactions. 28: A135-A135. DOI: 10.1042/BST028A135B  0.717
1999 Perozo E, Cortes DM, Cuello LG. Structural rearrangements underlying K+-channel activation gating. Science (New York, N.Y.). 285: 73-8. PMID 10390363 DOI: 10.1126/Science.285.5424.73  0.728
1998 Perozo E, Cortes DM, Cuello LG. Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy. Nature Structural Biology. 5: 459-69. PMID 9628484 DOI: 10.1038/Nsb0698-459  0.754
1998 Cuello LG, Romero JG, Cortes DM, Perozo E. pH-dependent gating in the Streptomyces lividans K+ channel. Biochemistry. 37: 3229-36. PMID 9536962 DOI: 10.1021/Bi972997X  0.837
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