David P. Hornby, Ph.D - Publications

Affiliations: 
1984-1985 Genetics University of Leeds, Leeds, England, United Kingdom 
 1985-1986 University of Basel, Basel, Basel-Stadt, Switzerland 
 1986- Molecular Biology and Biotechnology University of Sheffield, Sheffield, England, United Kingdom 
Area:
Enzymology
Website:
http://www.shef.ac.uk/mbb/staff/hornby

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Snijders AP, Hautbergue GM, Bloom A, Williamson JC, Minshull TC, Phillips HL, Mihaylov SR, Gjerde DT, Hornby DP, Wilson SA, Hurd PJ, Dickman MJ. Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA. Rna (New York, N.Y.). 21: 347-59. PMID 25605962 DOI: 10.1261/Rna.045138.114  0.313
2013 Qureshi MS, Sheikh QI, Hill R, Brown PE, Dickman MJ, Tzokov SB, Rice DW, Gjerde DT, Hornby DP. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Analytical Biochemistry. 439: 47-9. PMID 23583819 DOI: 10.1016/J.Ab.2013.03.035  0.302
2012 Hornby D, Ford K, Shore P. Purification of DNA binding proteins by affinity and ion exchange chromatography. Methods in Molecular Biology (Clifton, N.J.). 11: 273-86. PMID 21431673 DOI: 10.1385/0-89603-213-2:273  0.319
2006 Gjerde DT, Hanna CP, Hornby D, Bonn G. Nucleic Acid Chromatography Reviews in Cell Biology and Molecular Medicine. DOI: 10.1002/3527600906.Mcb.200400035  0.305
2004 Dickman MJ, Sedelnikova SE, Rafferty JB, Hornby DP. Rapid analysis of protein-nucleic acid complexes using MALDI TOF mass spectrometry and ion pair reverse phase liquid chromatography. Journal of Biochemical and Biophysical Methods. 58: 39-48. PMID 14597187 DOI: 10.1016/S0165-022X(03)00146-5  0.319
2003 Harris VH, Smith CL, Cummins WJ, Hamilton AL, Hornby DP, Williams DM. Recognition of base-pairing by DNA polymerases during nucleotide incorporation: the properties of the mutagenic nucleotide dPTP alphaS. Organic & Biomolecular Chemistry. 1: 2070-4. PMID 12945897 DOI: 10.1039/B302011H  0.385
2003 Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev SKh, Dryden DT, Dybvig K, Firman K, Gromova ES, Gumport RI, Halford SE, Hattman S, ... ... Hornby DP, et al. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Research. 31: 1805-12. PMID 12654995 DOI: 10.1093/Nar/Gkg274  0.344
2003 Harris VH, Smith CL, Jonathan Cummins W, Hamilton AL, Adams H, Dickman M, Hornby DP, Williams DM. The effect of tautomeric constant on the specificity of nucleotide incorporation during DNA replication: support for the rare tautomer hypothesis of substitution mutagenesis. Journal of Molecular Biology. 326: 1389-401. PMID 12595252 DOI: 10.1016/S0022-2836(03)00051-2  0.38
2003 Pinarbasi H, Pinarbasi E, Hornby DP. The small subunit of M. AquI is responsible for sequence-specific DNA recognition and binding in the absence of the catalytic domain. Journal of Bacteriology. 185: 1284-8. PMID 12562799 DOI: 10.1128/Jb.185.4.1284-1288.2003  0.377
2002 Dickman MJ, Ingleston SM, Sedelnikova SE, Rafferty JB, Lloyd RG, Grasby JA, Hornby DP. The RuvABC resolvasome. European Journal of Biochemistry / Febs. 269: 5492-501. PMID 12423347 DOI: 10.1046/J.1432-1033.2002.03250.X  0.358
2002 Bahrami AR, Dickman MJ, Matin MM, Ashby JR, Brown PE, Conroy MJ, Fowler GJ, Rose JP, Sheikh QI, Yeung AT, Hornby DP. Use of fluorescent DNA-intercalating dyes in the analysis of DNA via ion-pair reversed-phase denaturing high-performance liquid chromatography. Analytical Biochemistry. 309: 248-52. PMID 12413458 DOI: 10.1016/S0003-2697(02)00306-8  0.357
2002 Matin MM, Baumer A, Hornby DP. An analytical method for the detection of methylation differences at specific chromosomal loci using primer extension and ion pair reverse phase HPLC. Human Mutation. 20: 305-11. PMID 12325026 DOI: 10.1002/Humu.10118  0.357
2002 Pinarbasi H, Pinarbasi E, Hornby D. Recombinant alpha and beta subunits of M.AquI constitute an active DNA methyltransferase Journal of Biochemistry and Molecular Biology. 35: [d]348-351. PMID 12297020 DOI: 10.5483/Bmbrep.2002.35.3.348  0.377
2002 Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ, Hornby DP. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. Journal of Molecular Biology. 321: 591-9. PMID 12206775 DOI: 10.1016/S0022-2836(02)00676-9  0.368
2002 Ingleston SM, Dickman MJ, Grasby JA, Hornby DP, Sharples GJ, Lloyd RG. Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae. European Journal of Biochemistry / Febs. 269: 1525-33. PMID 11874468 DOI: 10.1046/J.1432-1033.2002.02805.X  0.384
2002 Dickman MJ, Matin MM, Hornby DP. High-throughput analysis of nucleic acid modification reactions using ion-pair reverse-phase high-performance liquid chromatography. Analytical Biochemistry. 301: 290-7. PMID 11814299 DOI: 10.1006/Abio.2001.5482  0.348
2002 Harris VH, Smith C, Cummins J, Hamilton A, Hornby DP, Williams DM. DNA replication with the mutagenic nucleotide dPTP; effects of tautomerism on nucleotide incorporation Collection of Czechoslovak Chemical Communications. 5: 215-220. DOI: 10.1135/Css200205215  0.345
2001 Lee SE, Sidorov A, Gourlain T, Mignet N, Thorpe SJ, Brazier JA, Dickman MJ, Hornby DP, Grasby JA, Williams DM. Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity. Nucleic Acids Research. 29: 1565-73. PMID 11266559 DOI: 10.1093/Nar/29.7.1565  0.349
2000 Rösler A, Panayotou G, Hornby DP, Barlow T, Brown T, Pearl LH, Savva R, Blackburn GM. The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues. Nucleosides, Nucleotides & Nucleic Acids. 19: 1505-16. PMID 11200255 DOI: 10.1080/15257770008045442  0.378
2000 Dickman M, Hornby DP. Isolation of single-stranded DNA using denaturing DNA chromatography. Analytical Biochemistry. 284: 164-7. PMID 10933872 DOI: 10.1006/Abio.2000.4669  0.356
1999 Hurd PJ, Whitmarsh AJ, Baldwin GS, Kelly SM, Waltho JP, Price NC, Connolly BA, Hornby DP. Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone. Journal of Molecular Biology. 286: 389-401. PMID 9973559 DOI: 10.1006/Jmbi.1998.2491  0.369
1998 Matin MM, Hornby DP. Exploring the structural flexibility of 5m-cytosine-DNA methyltransferases. Biochemical Society Transactions. 26: S394. PMID 10047908 DOI: 10.1042/Bst026S394  0.317
1998 Hornby DP, Ford GC. Protein-mediated base flipping. Current Opinion in Biotechnology. 9: 354-358. PMID 9751641 DOI: 10.1016/S0958-1669(98)80007-4  0.401
1996 Pinarbasi E, Elliott J, Hornby DP. Activation of a yeast pseudo DNA methyltransferase by deletion of a single amino acid. Journal of Molecular Biology. 257: 804-13. PMID 8636983 DOI: 10.1006/Jmbi.1996.0203  0.417
1995 Ford KG, Hornby DP, al Harrasy WS. Identification of direct-repeat-binding protein 1 (DRP-1), a DNA-binding protein that binds specifically to the 'malic' enzyme gene promoter direct repeat element. The Biochemical Journal. 311: 901-4. PMID 7487948 DOI: 10.1042/Bj3110901  0.34
1994 Baldwin GS, Kelly SM, Price NC, Wilson GW, Connolly BA, Artymiuk PJ, Hornby DP. Ligand-induced conformational states of the cytosine-specific DNA methyltransferase M.HgaI-2. Journal of Molecular Biology. 235: 545-53. PMID 8289281 DOI: 10.1006/Jmbi.1994.1012  0.402
1994 Ford K, Waltho J, Hornby D. Component analysis and characterization of a nuclear deoxyribonucleotidase Biochemical Journal. 298: 727-732. PMID 8141789 DOI: 10.1042/Bj2980727  0.331
1994 Syed SE, Hornby DP, Brown PE, Fitton JE, Engel PC. Site and significance of chemically modifiable cysteine residues in glutamate dehydrogenase of Clostridium symbiosum and the use of protection studies to measure coenzyme binding. The Biochemical Journal. 298: 107-13. PMID 8129708 DOI: 10.1042/Bj2980107  0.588
1994 Hornby DP, Whitmarsh A, Pinarbasi H, Kelly SM, Price NC, Shore P, Baldwin GS, Waltho J. The DNA recognition subunit of a DNA methyltransferase is predominantly a molten globule in the absence of DNA. Febs Letters. 355: 57-60. PMID 7957963 DOI: 10.1016/0014-5793(94)01171-0  0.413
1993 Hornby DP. DNA methyltransferases (EC 2.1.1.72 and EC 2.1.1.73). Methods in Molecular Biology (Clifton, N.J.). 16: 201-11. PMID 19082973 DOI: 10.1385/0-89603-234-5:201  0.36
1993 Taylor C, Ford K, Connolly BA, Hornby DP. Determination of the order of substrate addition to MspI DNA methyltransferase using a novel mechanism-based inhibitor. The Biochemical Journal. 291: 493-504. PMID 8484730 DOI: 10.1042/Bj2910493  0.443
1993 Ford K, Taylor C, Connolly B, Hornby DP. Effects of co-factor and deoxycytidine substituted oligonucleotides upon sequence-specific interactions between MspI DNA methyltransferase and DNA. Journal of Molecular Biology. 230: 779-86. PMID 8478933 DOI: 10.1006/Jmbi.1993.1200  0.41
1993 Soultanas P, Andrews PD, Burton DR, Hornby DP. Modulation of human DNA methyltransferase activity and mRNA levels in the monoblast cell line U937 induced to differentiate with dibutyryl cyclic AMP and phorbol ester. Journal of Molecular Endocrinology. 11: 191-200. PMID 8297475 DOI: 10.1677/Jme.0.0110191  0.625
1992 Kusiak M, Price C, Rice D, Hornby DP. The HsdS polypeptide of the type IC restriction enzyme EcoR124 is a sequence-specific DNA-binding protein. Molecular Microbiology. 6: 3251-6. PMID 1453962 DOI: 10.1111/J.1365-2958.1992.Tb01779.X  0.409
1992 Dalton A, Hornby DP, Langston SP, Blackburn GM. Characterization and purification of a novel dATP-binding protein in eukaryotes. The Biochemical Journal. 287: 871-9. PMID 1445246 DOI: 10.1042/Bj2870871  0.404
1988 Hümbelin M, Suri B, Rao DN, Hornby DP, Eberle H, Pripfl T, Kenel S, Bickle TA. Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants. Journal of Molecular Biology. 200: 23-9. PMID 2837577 DOI: 10.1016/0022-2836(88)90330-0  0.309
1988 LILLEY KS, HORNBY DP, ENGEL PC. Purification, chemical modification and analysis of pH-dependence of the NADP+-dependent glutamate dehydrogenase of Escherichia coli Biochemical Society Transactions. 16: 876-877. DOI: 10.1042/Bst0160876  0.557
1987 Rice DW, Baker PJ, Farrants GW, Hornby DP. The crystal structure of glutamate dehydrogenase from Clostridium symbiosum at 0.6 nm resolution. The Biochemical Journal. 242: 789-95. PMID 3593276 DOI: 10.1042/Bj2420789  0.313
1987 Hornby DP, Müller M, Bickle TA. High level expression of the EcoP1 modification methylase gene and characterisation of the gene product. Gene. 54: 239-45. PMID 2820845 DOI: 10.1016/0378-1119(87)90492-6  0.335
1987 HORNBY DP, BICKLE TA. Characterization of EcoP1 DNA adenine methylase Biochemical Society Transactions. 15: 1039-1039. DOI: 10.1042/Bst0151039  0.352
1987 ENGEL PC, HORNBY DP. A simple method for the calibration of recording fluorimeters by kinetic means in the study of NAD(P)+-dependent dehydrogenases Biochemical Society Transactions. 15: 386-387. DOI: 10.1042/Bst0150386  0.488
1985 Hornby DP, Engel PC, Hatanaka S. Kinetic studies of ox-liver glutamate dehydrogenase oxidative deamination of two glutamate analogues, L-threo-gamma-methylglutamate and L-alpha-amino-gamma-nitraminobutyrate, in the presence of the allosteric effector ADP. The International Journal of Biochemistry. 17: 851-4. PMID 4054426 DOI: 10.1016/0020-711X(85)90277-0  0.558
1985 Rice DW, Hornby DP, Engel PC. Crystallization of an NAD+-dependent glutamate dehydrogenase from Clostridium symbiosum. Journal of Molecular Biology. 181: 147-9. PMID 3981633 DOI: 10.1016/0022-2836(85)90334-1  0.524
1984 Hornby DP, Engel PC. Characterization of Peptostreptococcus asaccharolyticus glutamate dehydrogenase purified by dye-ligand chromatography. Journal of General Microbiology. 130: 2385-94. PMID 6502134 DOI: 10.1099/00221287-130-9-2385  0.586
1984 Hornby DP, Aitchison MJ, Engel PC. The kinetic mechanism of ox liver glutamate dehydrogenase in the presence of the allosteric effector ADP. The oxidative deamination of L-glutamate. The Biochemical Journal. 223: 161-8. PMID 6149744 DOI: 10.1042/Bj2230161  0.573
1984 Hornby DP, Engel PC. A kinetic study of the oxidative deamination of L-glutamate by Peptostreptococcus asaccharolyticus glutamate dehydrogenase using a variety of coenzymes. European Journal of Biochemistry / Febs. 143: 557-60. PMID 6148240 DOI: 10.1111/J.1432-1033.1984.Tb08405.X  0.571
1983 Hornby DP, Engel PC, Hatanaka S. Beef liver glutamate dehydrogenase: a study of the oxidation of various alternative amino acid substrates retaining the correct spacing of the two carboxylate groups. The International Journal of Biochemistry. 15: 495-500. PMID 6852348 DOI: 10.1016/0020-711X(83)90122-2  0.559
1983 HORNBY DP, ENGEL PC. The coenzyme specificity of glutamate dehydrogenase from Peptococcus asaccharolyticus Biochemical Society Transactions. 11: 175-176. DOI: 10.1042/Bst0110175  0.543
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