Year |
Citation |
Score |
2020 |
Gunnell EA, Al-Noori A, Muhsen U, Davies CC, Dowden J, Dreveny I. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4). The Biochemical Journal. PMID 32011657 DOI: 10.2210/Pdb6S7C/Pdb |
0.588 |
|
2011 |
Dowden J, Pike RA, Parry RV, Hong W, Muhsen UA, Ward SG. Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1. Organic & Biomolecular Chemistry. 9: 7814-21. PMID 21952734 DOI: 10.1039/C1Ob06100C |
0.592 |
|
2011 |
Hong W, Dowden J. Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases Chinese Chemical Letters. 22: 1439-1442. DOI: 10.1016/J.Cclet.2011.09.007 |
0.449 |
|
2010 |
Dowden J, Hong W, Parry RV, Pike RA, Ward SG. Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases. Bioorganic & Medicinal Chemistry Letters. 20: 2103-5. PMID 20219369 DOI: 10.1016/J.Bmcl.2010.02.069 |
0.436 |
|
2010 |
Stevenson B, Lewis W, Dowden J. Expedient route to an amine precursor of halichlorine and pinnaic acid from nitrocyclopent-1-ene Synlett. 672-674. DOI: 10.1055/S-0029-1219337 |
0.344 |
|
2007 |
Foster SR, Pearce A, Blake AJ, Welham MJ, Dowden J. Novel octavalent cross-linker displays efficient trapping of protein-protein interactions. Chemical Communications (Cambridge, England). 2512-4. PMID 17563813 DOI: 10.1039/B701542A |
0.309 |
|
2007 |
Parkesh R, Vasudevan SR, Berry A, Galione A, Dowden J, Churchill GC. Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+). Organic & Biomolecular Chemistry. 5: 441-3. PMID 17252124 DOI: 10.1039/B617344F |
0.38 |
|
2007 |
Anderson C, Bartlett SJ, Gansner JM, Wilson D, He L, Gitlin JD, Kelsh RN, Dowden J. Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis. Molecular Biosystems. 3: 51-9. PMID 17216056 DOI: 10.1039/B613673G |
0.334 |
|
2006 |
Dowden J, Berridge G, Moreau C, Yamasaki M, Churchill GC, Potter BV, Galione A. Cell-permeant small-molecule modulators of NAADP-mediated Ca2+ release. Chemistry & Biology. 13: 659-65. PMID 16793523 DOI: 10.1016/J.Chembiol.2006.05.005 |
0.306 |
|
2005 |
Dowden J, Brown RS, Moreau C, Galione A, Potter BV. Chemical synthesis of the novel Ca2+ messenger NAADP. Nucleosides, Nucleotides & Nucleic Acids. 24: 513-8. PMID 16247981 DOI: 10.1081/Ncn-200061786 |
0.333 |
|
2004 |
Dowden J, Moreau C, Brown RS, Berridge G, Galione A, Potter BV. Chemical synthesis of the second messenger nicotinic acid adenine dinucleotide phosphate by total synthesis of nicotinamide adenine dinucleotide phosphate. Angewandte Chemie (International Ed. in English). 43: 4637-40. PMID 15352191 DOI: 10.1002/Anie.200460054 |
0.326 |
|
2003 |
Ward S, Sotsios Y, Dowden J, Bruce I, Finan P. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Chemistry & Biology. 10: 207-13. PMID 12670534 DOI: 10.1016/S1074-5521(03)00048-6 |
0.388 |
|
2001 |
Dowden J, Ward SG. Inhibitors of p56Ick: Assessing their potential as tools for manipulating T-lymphocte activation Expert Opinion On Therapeutic Patents. 11: 295-306. DOI: 10.1517/13543776.11.2.295 |
0.447 |
|
1999 |
Taylor P, Anderson V, Dowden J, Flitsch SL, Turner NJ, Loughran K, Walkinshaw MD. Novel mechanism of inhibition of elastase by beta-lactams is defined by two inhibitor crystal complexes. The Journal of Biological Chemistry. 274: 24901-5. PMID 10455164 DOI: 10.1074/Jbc.274.35.24901 |
0.355 |
|
1999 |
Dowden J, Edwards PD, Flack SS, Kilburn JD. Synthesis and binding properties of a macrocyclic peptide receptor Chemistry - a European Journal. 5: 79-89. DOI: 10.1002/(Sici)1521-3765(19990104)5:1<79::Aid-Chem79>3.0.Co;2-W |
0.601 |
|
1997 |
Dowden J, Edwards PD, Kilburn JD. Modified synthesis and binding properties of a peptide receptor Tetrahedron Letters. 38: 1095-1098. DOI: 10.1016/S0040-4039(97)00068-3 |
0.605 |
|
1995 |
Dowden J, Kilburn JD, Wright P. Synthetic developments in host-guest chemistry Contemporary Organic Synthesis. 2: 289-314. DOI: 10.1039/Co9970400061 |
0.519 |
|
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