Dominic Walsh - Publications

Neurology Harvard Medical School - Brigham and Women's Hospital 

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mengel D, Janelidze S, Glynn RJ, Liu W, Hansson O, Walsh DM. Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease. Annals of Neurology. PMID 32829532 DOI: 10.1002/ana.25885  0.52
2020 Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003  1
2020 Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase. Alzheimer's Research & Therapy. 12: 27. PMID 32192521 DOI: 10.1186/s13195-020-00593-7  1
2019 Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, ... ... Walsh DM, et al. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathologica. PMID 31853635 DOI: 10.1007/s00401-019-02114-9  0.64
2019 Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Frontiers in Neuroscience. 13: 1208. PMID 31849573 DOI: 10.3389/fnins.2019.01208  1
2019 Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. A vicious cycle of β amyloid-dependent neuronal hyperactivation. Science (New York, N.Y.). 365: 559-565. PMID 31395777 DOI: 10.1126/science.aay0198  0.52
2019 Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF. Annals of Neurology. PMID 31168802 DOI: 10.1002/ana.25513  1
2019 Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain. Brain : a Journal of Neurology. 142: 1441-1457. PMID 31032851 DOI: 10.1093/brain/awz066  1
2019 Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ. Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo. Neurobiology of Disease. PMID 30910746 DOI: 10.1016/j.nbd.2019.03.022  0.96
2018 Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris D, Walsh DM. PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity. Brain Research. PMID 30593771 DOI: 10.1016/j.brainres.2018.12.038  0.64
2018 Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone. Nature. PMID 30546139 DOI: 10.1038/s41586-018-0790-y  0.52
2018 Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, ... ... Walsh DM, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30419228 DOI: 10.1016/j.jalz.2018.09.010  1
2018 Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau . The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30355631 DOI: 10.1523/JNEUROSCI.1700-18.2018  0.96
2018 Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease. Nature Communications. 9: 2676. PMID 29992960 DOI: 10.1038/s41467-018-05068-w  1
2018 El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathologica. PMID 29982852 DOI: 10.1007/s00401-018-1880-5  1
2018 Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ. Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity. Cell Reports. 23: 1932-1938. PMID 29768194 DOI: 10.1016/j.celrep.2018.04.040  0.96
2018 O'Malley TT, Linse S, Walsh DM. Production and Use of Recombinant Aβ for Aggregation Studies. Methods in Molecular Biology (Clifton, N.J.). 1777: 307-320. PMID 29744844 DOI: 10.1007/978-1-4939-7811-3_19  0.64
2018 Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain. Acta Neuropathologica. PMID 29687257 DOI: 10.1007/s00401-018-1846-7  0.64
2018 Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International Journal of Molecular Sciences. 19. PMID 29495441 DOI: 10.3390/ijms19030663  1
2017 Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse T, Spires-Jones TL, Walsh DM. Human brain-derived Aβ oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29101243 DOI: 10.1523/JNEUROSCI.2009-17.2017  0.64
2017 Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 152-163. PMID 28053038 DOI: 10.1523/JNEUROSCI.1698-16.2016  1
2016 Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, ... ... Walsh D, et al. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell. PMID 28017613 DOI: 10.1016/j.ccell.2016.11.011  0.56
2016 O'Malley TT, Wittbold WM, Linse S, Walsh DM. The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer. Biochemistry. PMID 27750419 DOI: 10.1021/acs.biochem.6b00453  0.64
2016 Zhang D, Mably AJ, Walsh DM, Rowan MJ. Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. Cerebral Cortex (New York, N.Y. : 1991). PMID 27390019 DOI: 10.1093/cercor/bhw193  0.96
2016 Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's Disease : Jad. PMID 27258414 DOI: 10.3233/JAD-160007  0.4
2016 Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Reviews. Neuroscience. 17: 251-60. PMID 26988744 DOI: 10.1038/nrn.2016.13  1
2015 Szczepankiewicz O, Linse B, Meisl G, Thulin E, Frohm B, Sala Frigerio C, Colvin MT, Jacavone AC, Griffin RG, Knowles TP, Walsh DM, Linse S. N-terminal extensions retard Aβ42 fibril formation but allow cross-seeding and co-aggregation with Aβ42. Journal of the American Chemical Society. PMID 26535489 DOI: 10.1021/jacs.5b07849  1
2015 Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiology of Disease. 85: 111-121. PMID 26525100 DOI: 10.1016/j.nbd.2015.10.019  1
2015 Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M. Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier. Science Advances. 1: e1500472. PMID 26491725 DOI: 10.1126/sciadv.1500472  0.36
2015 Cantlon A, Frigerio CS, Walsh DM. Lessons from a Rare Familial Dementia: Amyloid and Beyond. Journal of Parkinson's Disease and Alzheimer's Disease. 2. PMID 26405694 DOI: 10.13188/2376-922X.1000009  0.56
2015 Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B. IgG Conformer's Binding to Amyloidogenic Aggregates. Plos One. 10: e0137344. PMID 26367058 DOI: 10.1371/journal.pone.0137344  0.64
2015 Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates. Advanced Healthcare Materials. PMID 26288378 DOI: 10.1002/adhm.201500487  0.64
2015 Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10851-65. PMID 26224867 DOI: 10.1523/JNEUROSCI.0387-15.2015  1
2015 Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM. Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiology of Disease. 82: 372-384. PMID 26215784 DOI: 10.1016/j.nbd.2015.07.008  0.64
2015 Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis EA, Walsh DM, Yang J, Shah JV. Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. Acs Chemical Neuroscience. PMID 26212450 DOI: 10.1021/acschemneuro.5b00176  1
2015 Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM. The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers. The Journal of Biological Chemistry. 290: 16502-16. PMID 25957407 DOI: 10.1074/jbc.M115.652263  0.56
2015 Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, et al. A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6265-76. PMID 25904780 DOI: 10.1523/JNEUROSCI.5109-14.2015  1
2015 Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM, Frosch MP, Walsh DM. The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25846299 DOI: 10.1016/j.jalz.2015.01.005  0.64
2015 Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/s13195-015-0100-y  1
2015 Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiology of Aging. 36: 1316-32. PMID 25619661 DOI: 10.1016/j.neurobiolaging.2014.11.022  1
2015 Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates Advanced Healthcare Materials. DOI: 10.1002/adhm.201500487  0.64
2014 Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 53: 3908-21. PMID 24840308 DOI: 10.1021/bi5003053  1
2014 Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I. APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses. Cell Reports. 7: 1560-76. PMID 24835997 DOI: 10.1016/j.celrep.2014.04.024  0.36
2014 Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J. Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6140-5. PMID 24790184 DOI: 10.1523/JNEUROSCI.3526-13.2014  1
2014 O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM. Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies. The Biochemical Journal. 461: 413-26. PMID 24785004 DOI: 10.1042/BJ20140219  1
2014 Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ. Simultaneous measurement of a range of particle sizes during Aβ1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy. Biochemical and Biophysical Research Communications. 448: 195-9. PMID 24769478 DOI: 10.1016/j.bbrc.2014.04.088  1
2014 Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ. mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo. Nature Communications. 5: 3374. PMID 24594908 DOI: 10.1038/ncomms4374  1
2014 Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics. 23: 3523-36. PMID 24524897 DOI: 10.1093/hmg/ddu064  1
2014 Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ. Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aβ in vivo. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130147. PMID 24298149 DOI: 10.1098/rstb.2013.0147  1
2014 Métais C, Brennan K, Mably AJ, Scott M, Walsh DM, Herron CE. Simvastatin treatment preserves synaptic plasticity in AβPPswe/PS1dE9 mice. Journal of Alzheimer's Disease : Jad. 39: 315-29. PMID 24164738 DOI: 10.3233/JAD-130257  1
2014 Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O'Nuallain B. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Research. 17: 97-104. PMID 24164623 DOI: 10.1089/rej.2013.1524  1
2013 An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH. Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo. Molecular Brain. 6: 47. PMID 24284042 DOI: 10.1186/1756-6606-6-47  1
2013 Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity. Nature Communications. 4: 2416. PMID 24022506 DOI: 10.1038/ncomms3416  1
2013 Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Human Molecular Genetics. 22: 3077-92. PMID 23585551 DOI: 10.1093/hmg/ddt164  0.36
2013 Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 99-112. PMID 23375565 DOI: 10.1016/j.jalz.2012.11.005  1
2013 Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E, Walsh DM. Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation. Neurobiology of Aging. 34: 1315-27. PMID 23182244 DOI: 10.1016/j.neurobiolaging.2012.10.028  1
2013 O'Dowd ST, Ardah MT, Johansson P, Lomakin A, Benedek GB, Roberts KA, Cummins G, El Agnaf OM, Svensson J, Zetterberg H, Lynch T, Walsh DM. The ELISA-measured increase in cerebrospinal fluid tau that discriminates Alzheimer's disease from other neurodegenerative disorders is not attributable to differential recognition of tau assembly forms. Journal of Alzheimer's Disease : Jad. 33: 923-8. PMID 23034520 DOI: 10.3233/JAD-2012-121393  1
2012 Cukalevski R, Boland B, Frohm B, Thulin E, Walsh D, Linse S. Role of aromatic side chains in amyloid β-protein aggregation. Acs Chemical Neuroscience. 3: 1008-16. PMID 23259036 DOI: 10.1021/cn300073s  0.48
2012 Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Bunk S, Hermann C, Farrell MA, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A, O'Nuallain B. Human anti-Aβ IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. Plos One. 7: e50317. PMID 23209707 DOI: 10.1371/journal.pone.0050317  0.52
2012 Moro ML, Giaccone G, Lombardi R, Indaco A, Uggetti A, Morbin M, Saccucci S, Di Fede G, Catania M, Walsh DM, Demarchi A, Rozemuller A, Bogdanovic N, Bugiani O, Ghetti B, et al. APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38. Acta Neuropathologica. 124: 809-21. PMID 23143229 DOI: 10.1007/s00401-012-1061-x  1
2012 Walsh DM, Teplow DB. Alzheimer's disease and the amyloid β-protein. Progress in Molecular Biology and Translational Science. 107: 101-24. PMID 22482449 DOI: 10.1016/B978-0-12-385883-2.00012-6  1
2012 McDonald JM, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM. The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain. Brain Research. 1450: 138-47. PMID 22440675 DOI: 10.1016/j.brainres.2012.02.041  1
2012 Nicholson AM, Wold LA, Walsh DM, Ferreira A. β-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Molecular Medicine (Cambridge, Mass.). 18: 178-85. PMID 22160219 DOI: 10.2119/molmed.2011.00366  1
2012 Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, ... ... Walsh DM, et al. Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nature Chemical Biology. 8: 93-101. PMID 22101602 DOI: 10.1038/nchembio.719  1
2011 O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM. A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ. Journal of Neurochemistry. 119: 189-201. PMID 21781116 DOI: 10.1111/j.1471-4159.2011.07389.x  1
2011 Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites. Nature Communications. 2: 336. PMID 21654636 DOI: 10.1038/ncomms1341  1
2011 Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ. Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7259-63. PMID 21593310 DOI: 10.1523/JNEUROSCI.6500-10.2011  1
2011 Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. The Embo Journal. 30: 2255-65. PMID 21527912 DOI: 10.1038/emboj.2011.138  1
2011 Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. 108: 5819-24. PMID 21421841 DOI: 10.1073/pnas.1017033108  1
2011 Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain. Methods in Molecular Biology (Clifton, N.J.). 670: 33-44. PMID 20967581 DOI: 10.1007/978-1-60761-744-0_3  1
2011 Welzel AT, Walsh DM. Aberrant protein structure and diseases of the brain. Irish Journal of Medical Science. 180: 15-22. PMID 20960238 DOI: 10.1007/s11845-010-0606-z  0.52
2011 Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of Aging. 32: 2211-8. PMID 20097446 DOI: 10.1016/j.neurobiolaging.2010.01.001  1
2011 Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. Cognitive effects of cell-derived and synthetically derived Aβ oligomers. Neurobiology of Aging. 32: 1784-94. PMID 20031278 DOI: 10.1016/j.neurobiolaging.2009.11.007  1
2010 Hellstrand E, Boland B, Walsh DM, Linse S. Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. Acs Chemical Neuroscience. 1: 13-8. PMID 22778803 DOI: 10.1021/cn900015v  0.48
2010 O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14411-9. PMID 20980598 DOI: 10.1523/JNEUROSCI.3537-10.2010  1
2010 Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. The Journal of Biological Chemistry. 285: 37415-26. PMID 20864542 DOI: 10.1074/jbc.M110.186411  1
2010 Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain : a Journal of Neurology. 133: 1328-41. PMID 20403962 DOI: 10.1093/brain/awq065  1
2010 Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x  1
2010 Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Experimental Neurology. 223: 334-46. PMID 19815015 DOI: 10.1016/j.expneurol.2009.09.024  0.48
2009 Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Molecular Neurodegeneration. 4: 48. PMID 19930651 DOI: 10.1186/1750-1326-4-48  1
2009 Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 48: 10894-904. PMID 19821615 DOI: 10.1021/bi901237k  1
2009 Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiology of Disease. 36: 293-302. PMID 19660551 DOI: 10.1016/j.nbd.2009.07.021  1
2009 Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 62: 788-801. PMID 19555648 DOI: 10.1016/j.neuron.2009.05.012  1
2009 Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/j.brainres.2009.01.008  1
2009 Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Archives of Neurology. 66: 190-9. PMID 19204155 DOI: 10.1001/archneurol.2008.565  1
2009 Walsh DM, Thulin E, Minogue AM, Gustavsson N, Pang E, Teplow DB, Linse S. A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. The Febs Journal. 276: 1266-81. PMID 19175671 DOI: 10.1111/j.1742-4658.2008.06862.x  1
2008 Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Lindman S, Minogue AM, Thulin E, Walsh DM, Dawson KA, Linse S. Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles. Journal of the American Chemical Society. 130: 15437-43. PMID 18954050 DOI: 10.1021/ja8041806  0.48
2008 Hu NW, Smith IM, Walsh DM, Rowan MJ. Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain : a Journal of Neurology. 131: 2414-24. PMID 18678563 DOI: 10.1093/brain/awn174  1
2008 Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiology of Disease. 31: 442-50. PMID 18602473 DOI: 10.1016/j.nbd.2008.06.001  1
2008 Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Medicine. 14: 837-42. PMID 18568035 DOI: 10.1038/nm1782  1
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, ... ... Walsh DM, et al. Substrate-targeting gamma-secretase modulators. Nature. 453: 925-9. PMID 18548070 DOI: 10.1038/nature07055  1
2008 Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4231-7. PMID 18417702 DOI: 10.1523/JNEUROSCI.5161-07.2008  1
2008 Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Molecular Medicine (Cambridge, Mass.). 14: 451-64. PMID 18368143 DOI: 10.2119/2007-00100.Irvine  1
2008 O'Shea SD, Smith IM, McCabe OM, Cronin MM, Walsh DM, O'Connor WT. Intracerebroventricular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat Sensors. 8: 7428-7437. DOI: 10.3390/s8117428  1
2007 Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/ajpath.2007.070105  1
2007 Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochemical Society Transactions. 35: 416-20. PMID 17371289 DOI: 10.1042/BST0350416  1
2007 Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2866-75. PMID 17360908 DOI: 10.1523/JNEUROSCI.4970-06.2007  1
2007 Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. Journal of Neurochemistry. 101: 1172-84. PMID 17286590 DOI: 10.1111/j.1471-4159.2006.04426.x  1
2006 Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/j.jalz.2006.08.008  0.36
2006 Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of Neurology. 60: 668-76. PMID 17192927 DOI: 10.1002/ana.21051  1
2006 Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (New York, N.Y.). 313: 1781-4. PMID 16990547 DOI: 10.1126/science.1131864  1
2006 Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. The Journal of Physiology. 572: 477-92. PMID 16469784 DOI: 10.1113/jphysiol.2005.103754  1
2005 Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochemical Society Transactions. 33: 1087-90. PMID 16246051 DOI: 10.1042/BST20051087  1
2005 Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nature Medicine. 11: 556-61. PMID 15834427 DOI: 10.1038/nm1234  1
2005 Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2455-62. PMID 15758153 DOI: 10.1523/JNEUROSCI.4391-04.2005  1
2005 Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nature Neuroscience. 8: 79-84. PMID 15608634 DOI: 10.1038/nn1372  1
2004 Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 44: 181-93. PMID 15450169 DOI: 10.1016/j.neuron.2004.09.010  1
2004 Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. Species-specific immune response to immunization with human versus rodent A beta peptide. Neurobiology of Aging. 25: 1141-51. PMID 15312960 DOI: 10.1016/j.neurobiolaging.2003.12.008  0.44
2004 Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neuroscience Letters. 366: 320-5. PMID 15288443 DOI: 10.1016/j.neulet.2004.05.060  1
2004 Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein and Peptide Letters. 11: 213-28. PMID 15182223 DOI: 10.2174/0929866043407174  1
2004 Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. The European Journal of Neuroscience. 19: 2839-46. PMID 15147317 DOI: 10.1111/j.1460-9568.2004.03389.x  1
2004 Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3370-8. PMID 15056716 DOI: 10.1523/JNEUROSCI.1633-03.2004  1
2003 Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 40: 1087-93. PMID 14687544 DOI: 10.1016/S0896-6273(03)00787-6  1
2003 Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/bi027375c  1
2003 Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 51-61. PMID 12762144 DOI: 10.3109/13506120308995259  1
2003 Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 37: 583-95. PMID 12597857  1
2002 Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochemical Society Transactions. 30: 552-7. PMID 12196135 DOI: 10.1042/BST0300552  1
2002 Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416: 535-9. PMID 11932745 DOI: 10.1038/416535a  1
2001 Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. The Biochemical Journal. 355: 869-77. PMID 11311152 DOI: 10.1042/BJ3550869  1
2000 Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nature Structural Biology. 7: 1095-9. PMID 11101888 DOI: 10.1038/81937  1
2000 Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 166-78. PMID 11019857 DOI: 10.3109/13506120009146831  1
2000 Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 39: 10831-9. PMID 10978169 DOI: 10.1021/bi001048s  1
1999 Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. The Journal of Biological Chemistry. 274: 25945-52. PMID 10464339 DOI: 10.1074/jbc.274.36.25945  1
1998 Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry. 273: 32730-8. PMID 9830016 DOI: 10.1074/jbc.273.49.32730  1
1997 Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. The Journal of Biological Chemistry. 272: 22364-72. PMID 9268388 DOI: 10.1074/jbc.272.35.22364  1
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