Mark S.P. Sansom - Publications

Affiliations: 
Biochemistry University of Oxford, Oxford, United Kingdom 

87 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kumar A, Basak S, Rao S, Gicheru Y, Mayer ML, Sansom MSP, Chakrapani S. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nature Communications. 11: 3752. PMID 32719334 DOI: 10.1038/s41467-020-17364-5  0.68
2020 Klesse G, Tucker SJ, Sansom MSP. Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT Receptor Channel. Acs Nano. PMID 32673478 DOI: 10.1021/acsnano.0c04387  0.72
2020 Domański J, Sansom MSP, Stansfeld PJ, Best RB. Atomistic mechanism of transmembrane helix association. Plos Computational Biology. 16: e1007919. PMID 32497094 DOI: 10.1371/journal.pcbi.1007919  0.44
2020 Klesse G, Rao S, Tucker SJ, Sansom MSP. Induced Polarization in MD Simulations of the 5HT3 Receptor Channel. Journal of the American Chemical Society. PMID 32336093 DOI: 10.1021/jacs.0c02394  0.72
2020 Yamamoto E, Domański J, Naughton FB, Best RB, Kalli AC, Stansfeld PJ, Sansom MSP. Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes. Science Advances. 6: eaay5736. PMID 32128410 DOI: 10.1126/sciadv.aay5736  0.44
2019 Corey RA, Stansfeld PJ, Sansom MSP. The energetics of protein-lipid interactions as viewed by molecular simulations. Biochemical Society Transactions. PMID 31872229 DOI: 10.1042/BST20190149  0.44
2019 Wang Q, Corey RA, Hedger G, Aryal P, Grieben M, Nasrallah C, Baronina A, Pike ACW, Shi J, Carpenter EP, Sansom MSP. Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2. Structure (London, England : 1993). PMID 31806353 DOI: 10.1016/j.str.2019.11.005  0.72
2019 Corey RA, Vickery ON, Sansom MSP, Stansfeld PJ. Insights into Membrane Protein-Lipid Interactions from Free Energy Calculations. Journal of Chemical Theory and Computation. PMID 31476127 DOI: 10.1021/acs.jctc.9b00548  0.44
2019 Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MSP. A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates. Proceedings of the National Academy of Sciences of the United States of America. PMID 31235590 DOI: 10.1073/pnas.1902702116  0.72
2019 Klesse G, Rao S, Sansom MSP, Tucker SJ. CHAP: A Versatile Tool for the Structural and Functional Annotation of Ion Channel Pores. Journal of Molecular Biology. PMID 31220459 DOI: 10.1016/j.jmb.2019.06.003  0.72
2019 Caffalette CA, Corey RA, Sansom MSP, Stansfeld PJ, Zimmer J. A lipid gating mechanism for the channel-forming O antigen ABC transporter. Nature Communications. 10: 824. PMID 30778065 DOI: 10.1038/s41467-019-08646-8  0.44
2018 Newport TD, Sansom MSP, Stansfeld PJ. The MemProtMD database: a resource for membrane-embedded protein structures and their lipid interactions. Nucleic Acids Research. PMID 30418645 DOI: 10.1093/nar/gky1047  0.44
2018 Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S. Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT receptor. Nature. 563: 270-274. PMID 30401837 DOI: 10.1038/s41586-018-0660-7  0.68
2018 Haynes T, Smith IPS, Wallace EJ, Trick JL, Sansom MSP, Khalid S. Electric-Field Driven Translocation of ssDNA Through Hydrophobic Nanopores. Acs Nano. PMID 29985578 DOI: 10.1021/acsnano.8b03365  0.6
2018 Rao S, Lynch CI, Klesse G, Oakley GE, Stansfeld PJ, Tucker SJ, Sansom MSP. Water and hydrophobic gates in ion channels and nanopores. Faraday Discussions. PMID 29969132 DOI: 10.1039/c8fd00013a  0.72
2018 Autzen H, Koldsø H, Stansfeld PJ, Gourdon P, Sansom MSP, Nissen P. Interactions of a Bacterial Cu(I)-ATPase with a Complex Lipid Environment. Biochemistry. PMID 29894640 DOI: 10.1021/acs.biochem.8b00326  0.44
2018 Chavent M, Karia D, Kalli AC, Domański J, Duncan AL, Hedger G, Stansfeld PJ, Seiradake E, Jones EY, Sansom MSP. Interactions of the EphA2 Kinase Domain with PIPs in Membranes: Implications for Receptor Function. Structure (London, England : 1993). PMID 29887500 DOI: 10.1016/j.str.2018.05.003  0.44
2018 Domański J, Sansom MSP, Stansfeld PJ, Best RB. Balancing Force Field Protein-Lipid Interactions To Capture Transmembrane Helix-Helix Association. Journal of Chemical Theory and Computation. PMID 29424543 DOI: 10.1021/acs.jctc.7b00983  0.44
2017 Duncan AL, Reddy T, Koldsø H, Hélie J, Fowler PW, Chavent M, Sansom MSP. Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes. Scientific Reports. 7: 16647. PMID 29192147 DOI: 10.1038/s41598-017-16865-6  0.44
2017 Clausen MV, Jarerattanachat V, Carpenter EP, Sansom MSP, Tucker SJ. Asymmetric mechanosensitivity in a eukaryotic ion channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923939 DOI: 10.1073/pnas.1708990114  0.72
2017 Nematian-Ardestani E, Jarerattanachat V, Aryal P, Sansom MSP, Tucker SJ. The Effects of Stretch Activation on Ionic Selectivity of the TREK-2 K2P K(+) Channel. Channels (Austin, Tex.). 0. PMID 28723241 DOI: 10.1080/19336950.2017.1356955  0.72
2017 Lacin E, Aryal P, Glaaser IW, Bodhinathan K, Tsai E, Marsh N, Tucker SJ, Sansom MSP, Slesinger PA. Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel. The Journal of General Physiology. PMID 28720589 DOI: 10.1085/jgp.201711801  0.72
2017 Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike AC, Carpenter EP, Baukrowitz T, Sansom MS, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure (London, England : 1993). PMID 28392258 DOI: 10.1016/j.str.2017.03.006  0.72
2017 Rao S, Klesse G, Stansfeld PJ, Tucker SJ, Sansom MS. A BEST Example of Channel Structure Annotation by Molecular Simulation. Channels (Austin, Tex.). 0. PMID 28319451 DOI: 10.1080/19336950.2017.1306163  0.72
2017 Trick JL, Song C, Wallace EJ, Sansom MS. Voltage Gating of a Biomimetic Nanopore: Electrowetting of a Hydrophobic Barrier. Acs Nano. PMID 28141923 DOI: 10.1021/acsnano.6b07865  0.6
2017 Fowler PW, Sansom MS, Reithmeier RA. Effect of the Southeast Asian Ovalocytosis Deletion on the Conformational Dynamics of the Signal-Anchor Transmembrane Segment 1 of the Red Cell Anion Exchanger 1 (AE1, Band 3, SLC4A1). Biochemistry. PMID 28068080 DOI: 10.1021/acs.biochem.6b00966  0.44
2017 Domański J, Hedger G, Best RB, Stansfeld PJ, Sansom MSP. Convergence and Sampling in Determining Free Energy Landscapes for Membrane Protein Association. The Journal of Physical Chemistry. B. 121: 3364-3375. PMID 27807980 DOI: 10.1021/acs.jpcb.6b08445  0.44
2016 Trick JL, Chelvaniththilan S, Klesse G, Aryal P, Wallace EJ, Tucker SJ, Sansom MS. Functional Annotation of Ion Channel Structures by Molecular Simulation. Structure (London, England : 1993). PMID 27866853 DOI: 10.1016/j.str.2016.10.005  0.72
2016 Fowler PW, Hélie J, Duncan A, Chavent M, Koldsø H, Sansom MS. Membrane stiffness is modified by integral membrane proteins. Soft Matter. 12: 7792-7803. PMID 27722554 DOI: 10.1039/c6sm01186a  0.44
2016 Fowler PW, Williamson JJ, Sansom MS, Olmsted PD. Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics. Journal of the American Chemical Society. PMID 27574865 DOI: 10.1021/jacs.6b04880  0.72
2016 Koldsø H, Reddy T, Fowler PW, Duncan AL, Sansom MS. Membrane Compartmentalization Reduces the Mobility of Lipids and Proteins within a Model Plasma Membrane. The Journal of Physical Chemistry. B. PMID 27483109 DOI: 10.1021/acs.jpcb.6b05846  0.44
2016 Kalli AC, Rog T, Vattulainen I, Campbell ID, Sansom MS. The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations. The Journal of Membrane Biology. PMID 27465729 DOI: 10.1007/s00232-016-9908-z  0.72
2016 Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R, Siebold C. Structural basis of Smoothened regulation by its extracellular domains. Nature. PMID 27437577 DOI: 10.1038/nature18934  0.72
2016 Jackson VA, Mehmood S, Chavent M, Roversi P, Carrasquero M, Del Toro D, Seyit-Bremer G, Ranaivoson FM, Comoletti D, Sansom MS, Robinson CV, Klein R, Seiradake E. Super-complexes of adhesion GPCRs and neural guidance receptors. Nature Communications. 7: 11184. PMID 27091502 DOI: 10.1038/ncomms11184  0.72
2016 Reithmeier RA, Casey JR, Kalli A, Sansom MS, Alguel Y, Iwata S. Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context. Biochimica Et Biophysica Acta. PMID 27058983 DOI: 10.1016/j.bbamem.2016.03.030  0.72
2016 Samsudin F, Parker JL, Sansom MS, Newstead S, Fowler PW. Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter. Cell Chemical Biology. 23: 299-309. PMID 27028887 DOI: 10.1016/j.chembiol.2015.11.015  0.44
2016 Garcia-Fandiño R, Piñeiro Á, Trick JL, Sansom MS. Lipid Bilayer Membrane Perturbation by Embedded Nanopores: A Simulation Study. Acs Nano. 10: 3693-701. PMID 26943498 DOI: 10.1021/acsnano.6b00202  0.6
2015 Li D, Stansfeld PJ, Sansom MS, Keogh A, Vogeley L, Howe N, Lyons JA, Aragao D, Fromme P, Fromme R, Basu S, Grotjohann I, Kupitz C, Rendek K, Weierstall U, et al. Ternary structure reveals mechanism of a membrane diacylglycerol kinase. Nature Communications. 6: 10140. PMID 26673816 DOI: 10.1038/ncomms10140  0.44
2015 Sharma S, Kim BN, Stansfeld PJ, Sansom MS, Lindau M. A Coarse Grained Model for a Lipid Membrane with Physiological Composition and Leaflet Asymmetry. Plos One. 10: e0144814. PMID 26659855 DOI: 10.1371/journal.pone.0144814  0.44
2015 Beale JH, Parker JL, Samsudin F, Barrett AL, Senan A, Bird LE, Scott D, Owens RJ, Sansom MS, Tucker SJ, Meredith D, Fowler PW, Newstead S. Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport. Structure (London, England : 1993). 23: 1889-99. PMID 26320580 DOI: 10.1016/j.str.2015.07.016  0.72
2015 Hanson SM, Sansom MS, Becker EB. Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse. Biochemistry. 54: 4033-41. PMID 26112884 DOI: 10.1021/acs.biochem.5b00235  0.72
2015 Jefferys E, Sands ZA, Shi J, Sansom MS, Fowler PW. Alchembed: A Computational Method for Incorporating Multiple Proteins into Complex Lipid Geometries. Journal of Chemical Theory and Computation. 11: 2743-2754. PMID 26089745 DOI: 10.1021/ct501111d  0.72
2015 Stansfeld PJ, Goose JE, Caffrey M, Carpenter EP, Parker JL, Newstead S, Sansom MS. MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes. Structure (London, England : 1993). 23: 1350-61. PMID 26073602 DOI: 10.1016/j.str.2015.05.006  0.72
2015 Rassam P, Copeland NA, Birkholz O, Tóth C, Chavent M, Duncan AL, Cross SJ, Housden NG, Kaminska R, Seger U, Quinn DM, Garrod TJ, Sansom MS, Piehler J, Baumann CG, et al. Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria. Nature. 523: 333-6. PMID 26061769 DOI: 10.1038/nature14461  0.72
2015 Trick JL, Aryal P, Tucker SJ, Sansom MS. Molecular simulation studies of hydrophobic gating in nanopores and ion channels. Biochemical Society Transactions. 43: 146-50. PMID 25849908 DOI: 10.1042/BST20140256  0.72
2015 Hanson SM, Newstead S, Swartz KJ, Sansom MS. Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. Biophysical Journal. 108: 1425-34. PMID 25809255 DOI: 10.1016/j.bpj.2015.02.013  0.72
2015 Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, ... Sansom MS, et al. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science (New York, N.Y.). 347: 1256-9. PMID 25766236 DOI: 10.1126/science.1261512  0.72
2015 Kalli AC, Sansom MS, Reithmeier RA. Molecular dynamics simulations of the bacterial UraA H+-uracil symporter in lipid bilayers reveal a closed state and a selective interaction with cardiolipin. Plos Computational Biology. 11: e1004123. PMID 25729859 DOI: 10.1371/journal.pcbi.1004123  0.72
2015 Reddy T, Shorthouse D, Parton DL, Jefferys E, Fowler PW, Chavent M, Baaden M, Sansom MS. Nothing to sneeze at: a dynamic and integrative computational model of an influenza A virion. Structure (London, England : 1993). 23: 584-97. PMID 25703376 DOI: 10.1016/j.str.2014.12.019  0.72
2015 Laurent B, Chavent M, Cragnolini T, Dahl AC, Pasquali S, Derreumaux P, Sansom MS, Baaden M. Epock: rapid analysis of protein pocket dynamics. Bioinformatics (Oxford, England). 31: 1478-80. PMID 25505095 DOI: 10.1093/bioinformatics/btu822  0.72
2015 Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel. Channels (Austin, Tex.). 9: 44-9. PMID 25487004 DOI: 10.4161/19336950.2014.981987  0.72
2015 Aryal P, Sansom MS, Tucker SJ. Hydrophobic gating in ion channels. Journal of Molecular Biology. 427: 121-30. PMID 25106689 DOI: 10.1016/j.jmb.2014.07.030  0.72
2014 Lee C, Yashiro S, Dotson DL, Uzdavinys P, Iwata S, Sansom MS, von Ballmoos C, Beckstein O, Drew D, Cameron AD. Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights. The Journal of General Physiology. 144: 529-44. PMID 25422503 DOI: 10.1085/jgp.201411219  0.72
2014 Chavent M, Reddy T, Goose J, Dahl AC, Stone JE, Jobard B, Sansom MS. Methodologies for the analysis of instantaneous lipid diffusion in MD simulations of large membrane systems. Faraday Discussions. 169: 455-75. PMID 25341001 DOI: 10.1039/c3fd00145h  0.72
2014 Jefferys E, Sansom MS, Fowler PW. NRas slows the rate at which a model lipid bilayer phase separates. Faraday Discussions. 169: 209-23. PMID 25340566 DOI: 10.1039/c3fd00131h  0.72
2014 Trick JL, Wallace EJ, Bayley H, Sansom MS. Designing a hydrophobic barrier within biomimetic nanopores. Acs Nano. 8: 11268-79. PMID 25317664 DOI: 10.1021/nn503930p  0.72
2014 Chavent M, Chetwynd AP, Stansfeld PJ, Sansom MS. Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation. Biochemistry. 53: 6641-52. PMID 25286141 DOI: 10.1021/bi500800x  0.44
2014 Kalli AC, Sansom MSP. Interactions of peripheral proteins with model membranes as viewed by molecular dynamics simulations Biochemical Society Transactions. 42: 1418-1424. PMID 25233425 DOI: 10.1042/BST20140144  0.72
2014 Tan J, Rouse SL, Li D, Pye VE, Vogeley L, Brinth AR, El Arnaout T, Whitney JC, Howell PL, Sansom MS, Caffrey M. A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa. Acta Crystallographica. Section D, Biological Crystallography. 70: 2054-68. PMID 25084326 DOI: 10.1107/S1399004714001850  0.72
2014 Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. Nature Communications. 5: 4377. PMID 25001086 DOI: 10.1038/ncomms5377  0.72
2014 Bollepalli MK, Fowler PW, Rapedius M, Shang L, Sansom MS, Tucker SJ, Baukrowitz T. State-dependent network connectivity determines gating in a K+ channel. Structure (London, England : 1993). 22: 1037-46. PMID 24980796 DOI: 10.1016/j.str.2014.04.018  0.72
2014 Simmons KJ, Jackson SM, Brueckner F, Patching SG, Beckstein O, Ivanova E, Geng T, Weyand S, Drew D, Lanigan J, Sharples DJ, Sansom MS, Iwata S, Fishwick CW, Johnson AP, et al. Molecular mechanism of ligand recognition by membrane transport protein, Mhp1. The Embo Journal. 33: 1831-44. PMID 24952894 DOI: 10.15252/embj.201387557  0.72
2014 Kalli AC, Devaney I, Sansom MSP. Interactions of phosphatase and tensin homologue (PTEN) proteins with phosphatidylinositol phosphates: Insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase Biochemistry. 53: 1724-1732. PMID 24588644 DOI: 10.1021/bi5000299  0.72
2014 Stelzl LS, Fowler PW, Sansom MS, Beckstein O. Flexible gates generate occluded intermediates in the transport cycle of LacY. Journal of Molecular Biology. 426: 735-51. PMID 24513108 DOI: 10.1016/j.jmb.2013.10.024  0.72
2014 Dunton TA, Goose JE, Gavaghan DJ, Sansom MS, Osborne JM. The free energy landscape of dimerization of a membrane protein, NanC. Plos Computational Biology. 10: e1003417. PMID 24415929 DOI: 10.1371/journal.pcbi.1003417  0.72
2014 Reddy T, Manrique S, Buyan A, Hall BA, Chetwynd A, Sansom MSP. Primary and secondary dimer interfaces of the fibroblast growth factor receptor 3 transmembrane domain: Characterization via multiscale molecular dynamics simulations Biochemistry. 53: 323-332. PMID 24397339 DOI: 10.1021/bi401576k  0.72
2014 Zubcevic L, Bavro VN, Muniz JR, Schmidt MR, Wang S, De Zorzi R, Venien-Bryan C, Sansom MS, Nichols CG, Tucker SJ. Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains. The Journal of Biological Chemistry. 289: 143-51. PMID 24257749 DOI: 10.1074/jbc.M113.501833  0.72
2013 Fowler PW, Abad E, Beckstein O, Sansom MS. Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels. Journal of Chemical Theory and Computation. 9: 5176-5189. PMID 24353479 DOI: 10.1021/ct4005933  0.72
2013 Kalli AC, Campbell ID, Sansom MSP. Conformational Changes in Talin on Binding to Anionic Phospholipid Membranes Facilitate Signaling by Integrin Transmembrane Helices Plos Computational Biology. 9. PMID 24204243 DOI: 10.1371/journal.pcbi.1003316  0.72
2013 Fowler PW, Beckstein O, Abad E, Sansom MS. Detailed Examination of a Single Conduction Event in a Potassium Channel. The Journal of Physical Chemistry Letters. 4: 3104-3109. PMID 24143269 DOI: 10.1021/jz4014079  0.72
2013 Kalli AC, Morgan G, Sansom MSP. Interactions of the auxilin-1 PTEN-like domain with model membranes result in nanoclustering of phosphatidyl inositol phosphates Biophysical Journal. 105: 137-145. PMID 23823232 DOI: 10.1016/j.bpj.2013.05.012  0.72
2013 Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MS, Sanguinetti MC, Baukrowitz T, Decher N. Side pockets provide the basis for a new mechanism of Kv channel-specific inhibition. Nature Chemical Biology. 9: 507-13. PMID 23728494 DOI: 10.1038/nchembio.1271  0.72
2013 Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, et al. Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states. Proceedings of the National Academy of Sciences of the United States of America. 110: 9710-5. PMID 23716676 DOI: 10.1073/pnas.1217042110  0.64
2013 Fowler PW, Sansom MS. The pore of voltage-gated potassium ion channels is strained when closed. Nature Communications. 4: 1872. PMID 23695666 DOI: 10.1038/ncomms2858  0.72
2013 Stansfeld PJ, Jefferys EE, Sansom MS. Multiscale simulations reveal conserved patterns of lipid interactions with aquaporins. Structure (London, England : 1993). 21: 810-9. PMID 23602661 DOI: 10.1016/j.str.2013.03.005  0.44
2013 Goose JE, Sansom MS. Reduced lateral mobility of lipids and proteins in crowded membranes. Plos Computational Biology. 9: e1003033. PMID 23592975 DOI: 10.1371/journal.pcbi.1003033  0.72
2013 Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP. The structural basis of ZMPSTE24-dependent laminopathies. Science (New York, N.Y.). 339: 1604-7. PMID 23539603 DOI: 10.1126/science.1231513  0.72
2013 Schmidt MR, Stansfeld PJ, Tucker SJ, Sansom MS. Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel. Biochemistry. 52: 279-81. PMID 23270460 DOI: 10.1021/bi301350s  0.72
2013 Fotinou C, Aittoniemi J, de Wet H, Polidori A, Pucci B, Sansom MS, Vénien-Bryan C, Ashcroft FM. Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles. The Febs Journal. 280: 1051-63. PMID 23253866 DOI: 10.1111/febs.12097  0.72
2012 Rollauer SE, Tarry MJ, Graham JE, Jääskeläinen M, Jäger F, Johnson S, Krehenbrink M, Liu SM, Lukey MJ, Marcoux J, McDowell MA, Rodriguez F, Roversi P, Stansfeld PJ, Robinson CV, ... Sansom MS, et al. Structure of the TatC core of the twin-arginine protein transport system. Nature. 492: 210-4. PMID 23201679 DOI: 10.1038/nature11683  0.72
2012 Yates LA, Lumb CN, Brahme NN, Zalyte R, Bird LE, De Colibus L, Owens RJ, Calderwood DA, Sansom MS, Gilbert RJ. Structural and functional characterization of the kindlin-1 pleckstrin homology domain. The Journal of Biological Chemistry. 287: 43246-61. PMID 23132860 DOI: 10.1074/jbc.M112.422089  0.72
2012 Crowet JM, Parton DL, Hall BA, Steinhauer S, Brasseur R, Lins L, Sansom MSP. Multi-scale simulation of the simian immunodeficiency virus fusion peptide Journal of Physical Chemistry B. 116: 13713-13721. PMID 23094791 DOI: 10.1021/jp3027385  0.72
2012 Vostrikov VV, Hall BA, Sansom MSP, Koeppe RE. Accommodation of a central arginine in a transmembrane peptide by changing the placement of anchor residues Journal of Physical Chemistry B. 116: 12980-12990. PMID 23030363 DOI: 10.1021/jp308182b  0.72
2012 Hall BA, Armitage JP, Sansom MSP. Mechanism of Bacterial Signal Transduction Revealed by Molecular Dynamics of Tsr Dimers and Trimers of Dimers in Lipid Vesicles Plos Computational Biology. 8. PMID 23028283 DOI: 10.1371/journal.pcbi.1002685  0.72
2012 Lindau M, Hall BA, Chetwynd A, Beckstein O, Sansom MS. Coarse-grain simulations reveal movement of the synaptobrevin C-terminus in response to piconewton forces. Biophysical Journal. 103: 959-69. PMID 23009845 DOI: 10.1016/j.bpj.2012.08.007  0.72
2012 Rapedius M, Schmidt MR, Sharma C, Stansfeld PJ, Sansom MS, Baukrowitz T, Tucker SJ. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin, Tex.). 6: 473-8. PMID 22991046 DOI: 10.4161/chan.22153  0.72
2012 de Wet H, Shimomura K, Aittoniemi J, Ahmad N, Lafond M, Sansom MS, Ashcroft FM. A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening. The Journal of Physiology. 590: 5025-36. PMID 22802590 DOI: 10.1113/jphysiol.2012.236075  0.72
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