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Jason E. Hein - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Catalysis, Kinetics, Crystallization, Robotics
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Foth PJ, Malig TC, Yu H, Bolduc TG, Hein JE, Sammis GM. Halide-Accelerated Acyl Fluoride Formation Using Sulfuryl Fluoride. Organic Letters. PMID 32806146 DOI: 10.1021/Acs.Orglett.0C02566  0.416
2020 Forget SM, Xia FR, Hein JE, Brumer H. Determination of biocatalytic parameters of a copper radical oxidase using real-time reaction progress monitoring. Organic & Biomolecular Chemistry. PMID 32108208 DOI: 10.1039/C9Ob02757B  0.392
2020 Malig TC, Tan Y, Wisniewski SR, Higman CS, Carrasquillo-Flores R, Ortiz A, Purdum GE, Kolotuchin S, Hein JE. Development of a telescoped synthesis of 4-(1H)-cyanoimidazole core accelerated by orthogonal reaction monitoring Reaction Chemistry & Engineering. 5: 1421-1428. DOI: 10.1039/D0Re00234H  0.445
2019 Jain N, Hein JE, Ciufolini MA. Oxidative Cyclization of Naphtholic Sulfonamides Mediated by a Chiral Hypervalent Iodine Reagent: Asymmetric Synthesis versus Resolution Synlett. 30: 1222-1227. DOI: 10.1055/S-0037-1611831  0.396
2019 Christensen M, Adedeji F, Grosser S, Zawatzky K, Ji Y, Liu J, Jurica JA, Naber JR, Hein JE. Development of an automated kinetic profiling system with online HPLC for reaction optimization Reaction Chemistry & Engineering. 4: 1555-1558. DOI: 10.1039/C9Re00086K  0.317
2019 Daponte JA, Guo Y, Ruck RT, Hein JE. Using an Automated Monitoring Platform for Investigations of Biphasic Reactions Acs Catalysis. 9: 11484-11491. DOI: 10.1021/Acscatal.9B03953  0.396
2018 Epifanov M, Foth PJ, Gu F, Barrillon C, Kanani SS, Higman CS, Hein JE, Sammis GM. One-Pot 1,1-Dihydrofluoroalkylation of Amines using Sulfuryl Fluoride. Journal of the American Chemical Society. PMID 30433772 DOI: 10.1021/Jacs.8B11309  0.461
2018 Malig TC, Yu D, Hein JE. A Revised Mechanism for the Kinugasa Reaction. Journal of the American Chemical Society. PMID 29966088 DOI: 10.1021/Jacs.8B04635  0.467
2018 Chung R, Vo A, Fokin VV, Hein JE. Catalyst Activation, Chemoselectivity, and Reaction Rate Controlled by the Counterion in the Cu(I)-Catalyzed Cycloaddition between Azide and Terminal or 1-Iodoalkynes Acs Catalysis. 8: 7889-7897. DOI: 10.1021/Acscatal.8B01342  0.73
2018 Das UK, Higman CS, Gabidullin B, Hein JE, Baker RT. Efficient and Selective Iron-Complex-Catalyzed Hydroboration of Aldehydes Acs Catalysis. 8: 1076-1081. DOI: 10.1021/Acscatal.7B03785  0.411
2017 Soley J, Chiu E, Chung R, Green J, Hein JE, Taylor SD. Synthesis of β-Ketosulfonamides Derived from Amino Acids and Their Conversion to β-Keto-α,α-difluorosulfonamides via Electrophilic Fluorination. The Journal of Organic Chemistry. PMID 29019682 DOI: 10.1021/Acs.Joc.7B02179  0.338
2017 Wilkerson-Hill SM, Yu D, Painter PP, Fisher EL, Tantillo DJ, Sarpong R, Hein JE. On the Mechanism of a No-metal-added Heterocycloisomerization of Alkynylcyclopropylhydrazones: A Synthesis of Cycloheptane-fused Aminopyrroles Facilitated by Copper Salts at Trace Loadings. Journal of the American Chemical Society. PMID 28683552 DOI: 10.1021/Jacs.7B06007  0.444
2017 Diemoz KM, Hein JE, Wilson SO, Fettinger JC, Franz AK. Reaction Progress Kinetics Analysis of 1,3-Disiloxanediols as Hydrogen-bonding Catalysts. The Journal of Organic Chemistry. PMID 28564545 DOI: 10.1021/Acs.Joc.7B00875  0.359
2017 Malig TC, Koenig JDB, Situ H, Chehal NK, Hultin PG, Hein JE. Real-time HPLC-MS reaction progress monitoring using an automated analytical platform Reaction Chemistry & Engineering. 2: 309-314. DOI: 10.1039/C7Re00026J  0.643
2017 Rougeot C, Situ H, Cao BH, Vlachos V, Hein JE. Automated reaction progress monitoring of heterogeneous reactions: crystallization-induced stereoselectivity in amine-catalyzed aldol reactions Reaction Chemistry & Engineering. 2: 226-231. DOI: 10.1039/C6Re00211K  0.422
2017 Chung R, Vo A, Hein JE. Copper-Catalyzed Hydrogen/Iodine Exchange in Terminal and 1-Iodoalkynes Acs Catalysis. 7: 2505-2510. DOI: 10.1021/Acscatal.6B03515  0.379
2017 Weatherly C, Alderson JM, Berry JF, Hein JE, Schomaker JM. Catalyst-Controlled Nitrene Transfer by Tuning Metal:Ligand Ratios: Insight into the Mechanisms of Chemoselectivity Organometallics. 36: 1649-1661. DOI: 10.1021/Acs.Organomet.7B00190  0.329
2017 Chung R, Hein JE. The More, The Better: Simultaneous In Situ Reaction Monitoring Provides Rapid Mechanistic and Kinetic Insight Topics in Catalysis. 60: 594-608. DOI: 10.1007/S11244-017-0737-9  0.391
2017 Phung C, Tantillo DJ, Hein JE, Pinhas AR. The mechanism of the reaction between an aziridine and carbon dioxide with no added catalyst Journal of Physical Organic Chemistry. 31: e3735. DOI: 10.1002/Poc.3735  0.393
2016 Squitieri RA, Shearn-Nance GP, Hein JE, Shaw JT. Synthesis of Esters by in situ Formation and Trapping of Diazoalkanes. The Journal of Organic Chemistry. PMID 27191835 DOI: 10.1021/Acs.Joc.6B00408  0.393
2016 Abel GR, Calabrese Z, Ayco J, Hein JE, Ye T. Measuring and suppressing the oxidative damage to DNA during Cu(I)-catalyzed azide-alkyne cycloaddition. Bioconjugate Chemistry. PMID 26829457 DOI: 10.1021/Acs.Bioconjchem.5B00665  0.403
2015 Chung R, Yu D, Thai VT, Jones AF, Veits GK, Read De Alaniz J, Hein JE. Tandem Reaction Progress Analysis as a Means for Dissecting Catalytic Reactions: Application to the Aza-Piancatelli Rearrangement Acs Catalysis. 5: 4579-4585. DOI: 10.1021/Acscatal.5B01087  0.422
2014 Berry MT, Castrejon D, Hein JE. Oxidative esterification of aldehydes using mesoionic 1,2,3-triazolyl carbene organocatalysts. Organic Letters. 16: 3676-9. PMID 24988367 DOI: 10.1021/Ol501458P  0.36
2013 Yu D, Thai VT, Palmer LI, Veits GK, Cook JE, de Alaniz JR, Hein JE. Importance of off-cycle species in the acid-catalyzed aza-Piancatelli rearrangement. The Journal of Organic Chemistry. 78: 12784-9. PMID 24304006 DOI: 10.1021/Jo402155B  0.389
2013 Hein JE, Gherase D, Blackmond DG. Chemical and physical models for the emergence of biological homochirality Topics in Current Chemistry. 333: 83-108. PMID 23271377 DOI: 10.1007/128_2012_397  0.517
2012 Worrell BT, Hein JE, Fokin VV. Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: synthesis and applications of 5-fluorotriazoles. Angewandte Chemie (International Ed. in English). 51: 11791-4. PMID 23059856 DOI: 10.1002/Anie.201204979  0.684
2012 Hein JE, Cao BH, Viedma C, Kellogg RM, Blackmond DG. Pasteur's tweezers revisited: on the mechanism of attrition-enhanced deracemization and resolution of chiral conglomerate solids. Journal of the American Chemical Society. 134: 12629-36. PMID 22779695 DOI: 10.1021/Ja303566G  0.53
2012 Hein JE, Blackmond DG. On the origin of single chirality of amino acids and sugars in biogenesis Accounts of Chemical Research. 45: 2045-2054. PMID 22353168 DOI: 10.1021/Ar200316N  0.565
2012 Hein JE, Krasnova LB, Iwasaki M, Fokin VV. Cu‐Catalyzed Azide‐Alkyne Cycloaddition: Preparation of Tris((1‐Benzyl‐1H‐1,2,3‐Triazolyl)Methyl)Amine Organic Syntheses. 88: 238-246. DOI: 10.1002/0471264229.Os088.23  0.702
2011 Millward SW, Henning RK, Kwong GA, Pitram S, Agnew HD, Deyle KM, Nag A, Hein J, Lee SS, Lim J, Pfeilsticker JA, Sharpless KB, Heath JR. Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1. Journal of the American Chemical Society. 133: 18280-8. PMID 21962254 DOI: 10.1021/Ja2064389  0.587
2011 Hein JE, Burés J, Lam YH, Hughes M, Houk KN, Armstrong A, Blackmond DG. Enamine carboxylates as stereodetermining intermediates in prolinate catalysis. Organic Letters. 13: 5644-7. PMID 21958394 DOI: 10.1021/Ol2023533  0.606
2011 Hein JE, Tse E, Blackmond DG. A route to enantiopure RNA precursors from nearly racemic starting materials Nature Chemistry. 3: 704-706. PMID 21860459 DOI: 10.1038/Nchem.1108  0.58
2011 Hein JE, Armstrong A, Blackmond DG. Kinetic profiling of prolinate-catalyzed α-amination of aldehydes Organic Letters. 13: 4300-4303. PMID 21761822 DOI: 10.1021/Ol201639Z  0.603
2011 Hein JE, Tse E, Blackmond DG. Enantiopure RNA Precursors from Nearly Racemic Starting Materials Synfacts. 2011: 1361-1361. DOI: 10.1055/S-0031-1289369  0.493
2011 Krasnova LB, Hein JE, Fokin VV. ChemInform Abstract: Synthesis of 7-Aza-5-deazapurine Analogues via Copper(I)-Catalyzed Hydroamination of Alkynes and 1-Iodoalkynes. Cheminform. 42: no-no. DOI: 10.1002/CHIN.201113173  0.369
2010 Krasnova LB, Hein JE, Fokin VV. Synthesis of 7-aza-5-deazapurine analogues via copper(I)-catalyzed hydroamination of alkynes and 1-iodoalkynes. The Journal of Organic Chemistry. 75: 8662-5. PMID 21105687 DOI: 10.1021/Jo1016376  0.749
2010 Hein JE, Fokin VV. Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides. Chemical Society Reviews. 39: 1302-15. PMID 20309487 DOI: 10.1039/B904091A  0.746
2010 Hein JE, Tripp JC, Krasnova LB, Sharpless KB, Fokin VV. ChemInform Abstract: Copper(I)-Catalyzed Cycloaddition of Organic Azides and 1-Iodoalkynes. Cheminform. 41. DOI: 10.1002/chin.201007113  0.745
2009 Hein JE, Tripp JC, Krasnova LB, Sharpless KB, Fokin VV. Copper(I)-catalyzed cycloaddition of organic azides and 1-iodoalkynes. Angewandte Chemie (International Ed. in English). 48: 8018-21. PMID 19774581 DOI: 10.1002/anie.200903558  0.744
2009 Agnew HD, Rohde RD, Millward SW, Nag A, Yeo WS, Hein JE, Pitram SM, Tariq AA, Burns VM, Krom RJ, Fokin VV, Sharpless KB, Heath JR. Iterative in situ click chemistry creates antibody-like protein-capture agents. Angewandte Chemie (International Ed. in English). 48: 4944-8. PMID 19301344 DOI: 10.1002/Anie.200900488  0.723
2009 Kwok SW, Hein JE, Fokin VV, Sharpless KB. ChemInform Abstract: Regioselective Synthesis of Either 1H- or 2H-1,2,3-Triazoles via Michael Addition to α,β-Unsaturated Ketones. Cheminform. 40. DOI: 10.1002/chin.200918132  0.718
2008 Kwok SW, Hein JE, Fokin VV, Sharpless KB. REGIOSELECTIVE SYNTHESIS OF EITHER 1H- OR 2H-1,2,3- TRIAZOLES VIA MICHAEL ADDITION TO α,ß-UNSATURATED KETONES. Heterocycles. 76: 1141-1154. PMID 19802363 DOI: 10.3987/Com-08-S(N)73  0.747
2006 Hein JE, Geary LM, Jaworski AA, Hultin PG. Synthesis of Chiral Fluorous Oxazolidinone Auxiliaries Synfacts. 2006: 139-139. DOI: 10.1055/S-2005-924779  0.365
2005 Hein JE, Geary LM, Jaworski AA, Hultin PG. Practical synthesis of fluorous oxazolidinone chiral auxiliaries from alpha-amino acids. The Journal of Organic Chemistry. 70: 9940-6. PMID 16292825 DOI: 10.1021/Jo051696N  0.694
2005 Hein JE, Zimmerman J, Sibi MP, Hultin PG. Stereoselective conjugate radical additions: Application of a fluorous oxazolidinone chiral auxiliary for efficient tin removal Organic Letters. 7: 2755-2758. PMID 15957939 DOI: 10.1021/Ol050956K  0.716
2005 Hein JE, Hultin PG. Recyclable supports for stereoselective 1,3-dipolar cycloadditions: Application of a fluorous oxazolidinone chiral auxiliary Tetrahedron Asymmetry. 16: 2341-2347. DOI: 10.1016/J.Tetasy.2005.05.041  0.708
2003 Hein JE, Hultin PG. Asymmetric Aldol Reactions Using a Fluorous Oxazolidinone Chiral Auxiliary. Cheminform. 34. DOI: 10.1055/S-2003-38371  0.716
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