| Year |
Citation |
Score |
| 2020 |
Beers DR, Zhao W, Neal DW, Thonhoff JR, Thome AD, Faridar A, Wen S, Wang J, Appel SH. Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis. Scientific Reports. 10: 15295. PMID 32943739 DOI: 10.1038/S41598-020-72247-5 |
0.349 |
|
| 2020 |
Zhao W, Beers DR, Thonhoff JR, Thome AD, Faridar A, Wang J, Wen S, Ornelas L, Sareen D, Goodridge HS, Svendsen CN, Appel SH. Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls. Iscience. 23: 101192. PMID 32521508 DOI: 10.1016/J.Isci.2020.101192 |
0.323 |
|
| 2020 |
Du Y, Zhao W, Thonhoff JR, Wang J, Wen S, Appel SH. Increased activation ability of monocytes from ALS patients. Experimental Neurology. 113259. PMID 32105709 DOI: 10.1016/J.Expneurol.2020.113259 |
0.341 |
|
| 2019 |
Garbuzova-Davis S, Ehrhart J, Mustafa H, Llauget A, Boccio KJ, Sanberg PR, Appel SH, Borlongan CV. Phenotypic Characteristics of Human Bone Marrow-Derived Endothelial Progenitor Cells in vitro Support Cell Effectiveness for Repair of the Blood-Spinal Cord Barrier in ALS. Brain Research. 146428. PMID 31493389 DOI: 10.1016/J.Brainres.2019.146428 |
0.335 |
|
| 2019 |
Cykowski MD, Dickson DW, Powell SZ, Arumanayagam AS, Rivera AL, Appel SH. Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion. Acta Neuropathologica. PMID 31375896 DOI: 10.1007/S00401-019-02050-8 |
0.317 |
|
| 2019 |
Garbuzova-Davis S, Kurien C, Haller E, Eve DJ, Navarro S, Steiner G, Mahendrasah A, Hailu S, Khatib M, Boccio KJ, Borlongan CV, Van Loveren HR, Appel SH, Sanberg PR. Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier. Scientific Reports. 9: 5280. PMID 30918315 DOI: 10.1038/S41598-019-41747-4 |
0.337 |
|
| 2019 |
Beers DR, Appel SH. Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies. The Lancet. Neurology. 18: 211-220. PMID 30663610 DOI: 10.1016/S1474-4422(18)30394-6 |
0.358 |
|
| 2018 |
Garbuzova-Davis S, Haller E, Navarro S, Besong TE, Boccio KJ, Hailu S, Khatib M, Sanberg PR, Appel SH, Borlongan CV. Transplantation of human bone marrow stem cells into symptomatic ALS mice enhanced structural and functional blood-spinal cord barrier repair. Experimental Neurology. PMID 30172620 DOI: 10.1016/J.Expneurol.2018.08.012 |
0.33 |
|
| 2018 |
Thonhoff JR, Simpson EP, Appel SH. Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis. Current Opinion in Neurology. PMID 30048339 DOI: 10.1097/Wco.0000000000000599 |
0.38 |
|
| 2018 |
Thonhoff JR, Beers DR, Zhao W, Pleitez M, Simpson EP, Berry JD, Cudkowicz ME, Appel SH. Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study. Neurology(R) Neuroimmunology & Neuroinflammation. 5: e465. PMID 29845093 DOI: 10.1212/Nxi.0000000000000465 |
0.326 |
|
| 2018 |
Cykowski MD, Powell SZ, Appel JW, Arumanayagam AS, Rivera AL, Appel SH. Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 6: 28. PMID 29653597 DOI: 10.1186/S40478-018-0528-Y |
0.354 |
|
| 2018 |
Fournier CN, Schoenfeld D, Berry JD, Cudkowicz ME, Chan J, Quinn C, Brown RH, Salameh JS, Tansey MG, Beers DR, Appel SH, Glass JD. An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 29308669 DOI: 10.1080/21678421.2017.1421666 |
0.348 |
|
| 2017 |
Miller RG, Appel SH. Introduction to supplement: the current status of treatment for ALS. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 18: 1-4. PMID 28872909 DOI: 10.1080/21678421.2017.1361447 |
0.309 |
|
| 2017 |
Cykowski MD, Powell SZ, Peterson LE, Appel JW, Rivera AL, Takei H, Chang E, Appel SH. Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis. Journal of Neuropathology and Experimental Neurology. 76: 402-413. PMID 28521037 DOI: 10.1093/Jnen/Nlx025 |
0.326 |
|
| 2017 |
Lange DJ, Shahbazi M, Silani V, Ludolph AC, Weishaupt JH, Ajroud-Driss S, Fields KG, Remanan R, Appel SH, Morelli C, Doretti A, Maderna L, Messina S, Weiland U, Marklund SL, et al. Pyrimethamine Significantly Lowers CSF/SOD1 in ALS Patients With SOD1 Mutations. Annals of Neurology. PMID 28480639 DOI: 10.1002/Ana.24950 |
0.308 |
|
| 2017 |
Zhao W, Beers DR, Hooten KG, Sieglaff DH, Zhang A, Kalyana-Sundaram S, Traini CM, Halsey WS, Hughes AM, Sathe GM, Livi GP, Fan GH, Appel SH. Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes. Jama Neurology. PMID 28437540 DOI: 10.1001/Jamaneurol.2017.0357 |
0.368 |
|
| 2017 |
Beers DR, Zhao W, Wang J, Zhang X, Wen S, Neal D, Thonhoff JR, Alsuliman AS, Shpall EJ, Rezvani K, Appel SH. ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity. Jci Insight. 2: e89530. PMID 28289705 DOI: 10.1172/Jci.Insight.89530 |
0.362 |
|
| 2016 |
Alsuliman A, Appel SH, Beers DR, Basar R, Shaim H, Kaur I, Zulovich J, Yvon E, Muftuoglu M, Imahashi N, Kondo K, Liu E, Shpall EJ, Rezvani K. A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy. Cytotherapy. PMID 27497700 DOI: 10.1016/J.Jcyt.2016.06.012 |
0.367 |
|
| 2016 |
Appel SH, Armon C. Stem cells in amyotrophic lateral sclerosis: Ready for prime time? Neurology. PMID 27358334 DOI: 10.1212/Wnl.0000000000002906 |
0.353 |
|
| 2016 |
Bali T, Self W, Liu J, Siddique T, Wang LH, Bird TD, Ratti E, Atassi N, Boylan KB, Glass JD, Maragakis NJ, Caress JB, McCluskey LF, Appel SH, Wymer JP, et al. Defining SOD1 ALS natural history to guide therapeutic clinical trial design. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27261500 DOI: 10.1136/Jnnp-2016-313521 |
0.318 |
|
| 2015 |
Zhao W, Beers DR, Bell S, Wang J, Wen S, Baloh RH, Appel SH. TDP-43 activates microglia through NF-κB and NLRP3 inflammasome. Experimental Neurology. 273: 24-35. PMID 26222336 DOI: 10.1016/J.Expneurol.2015.07.019 |
0.339 |
|
| 2015 |
Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, ... ... Appel S, et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science (New York, N.Y.). 347: 1436-41. PMID 25700176 DOI: 10.1126/Science.Aaa3650 |
0.333 |
|
| 2015 |
Hooten KG, Beers DR, Zhao W, Appel SH. Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 364-75. PMID 25567201 DOI: 10.1007/S13311-014-0329-3 |
0.373 |
|
| 2014 |
Cykowski MD, Takei H, Schulz PE, Appel SH, Powell SZ. TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 2: 171. PMID 25539830 DOI: 10.1186/S40478-014-0171-1 |
0.324 |
|
| 2014 |
Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. Jama Neurology. 71: 449-53. PMID 24535663 DOI: 10.1001/Jamaneurol.2013.6237 |
0.35 |
|
| 2013 |
Zhao W, Beers DR, Appel SH. Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 888-99. PMID 23881705 DOI: 10.1007/S11481-013-9489-X |
0.36 |
|
| 2013 |
Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, et al. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 5-18. PMID 23678876 DOI: 10.3109/21678421.2013.778548 |
0.359 |
|
| 2013 |
Miller TM, Pestronk A, David W, Rothstein J, Simpson E, Appel SH, Andres PL, Mahoney K, Allred P, Alexander K, Ostrow LW, Schoenfeld D, Macklin EA, Norris DA, Manousakis G, et al. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study. The Lancet. Neurology. 12: 435-42. PMID 23541756 DOI: 10.1016/S1474-4422(13)70061-9 |
0.309 |
|
| 2013 |
Henkel JS, Beers DR, Wen S, Rivera AL, Toennis KM, Appel JE, Zhao W, Moore DH, Powell SZ, Appel SH. Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival. Embo Molecular Medicine. 5: 64-79. PMID 23143995 DOI: 10.1002/Emmm.201201544 |
0.326 |
|
| 2013 |
Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathologica. 125: 111-20. PMID 22941226 DOI: 10.1007/S00401-012-1039-8 |
0.368 |
|
| 2012 |
Appel SH, Rowland LP. Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62: a functional convergence? Neurology. 79: 1526-7. PMID 22972643 DOI: 10.1212/Wnl.0B013E31826E26Ec |
0.329 |
|
| 2012 |
Liao B, Zhao W, Beers DR, Henkel JS, Appel SH. Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS. Experimental Neurology. 237: 147-52. PMID 22735487 DOI: 10.1016/J.Expneurol.2012.06.011 |
0.347 |
|
| 2012 |
Kano O, Beers DR, Henkel JS, Appel SH. Peripheral nerve inflammation in ALS mice: cause or consequence. Neurology. 78: 833-5. PMID 22377817 DOI: 10.1212/Wnl.0B013E318249F776 |
0.316 |
|
| 2011 |
Vaknin I, Kunis G, Miller O, Butovsky O, Bukshpan S, Beers DR, Henkel JS, Yoles E, Appel SH, Schwartz M. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. Plos One. 6: e26921. PMID 22073221 DOI: 10.1371/Journal.Pone.0026921 |
0.377 |
|
| 2011 |
Beers DR, Henkel JS, Zhao W, Wang J, Huang A, Wen S, Liao B, Appel SH. Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain : a Journal of Neurology. 134: 1293-314. PMID 21596768 DOI: 10.1093/Brain/Awr074 |
0.312 |
|
| 2011 |
Beers DR, Zhao W, Liao B, Kano O, Wang J, Huang A, Appel SH, Henkel JS. Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice. Brain, Behavior, and Immunity. 25: 1025-35. PMID 21176785 DOI: 10.1016/J.Bbi.2010.12.008 |
0.336 |
|
| 2011 |
Jawaid A, Poon M, Strutt AM, Rice LK, McDowell EJ, Salamone AR, Qureshi SU, Simpson E, Appel SH, York MK, Schulz PE. Does apolipoprotein E genotype modify the clinical expression of ALS? European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 18: 618-24. PMID 20880000 DOI: 10.1111/J.1468-1331.2010.03225.X |
0.337 |
|
| 2010 |
Jawaid A, Salamone AR, Strutt AM, Murthy SB, Wheaton M, McDowell EJ, Simpson E, Appel SH, York MK, Schulz PE. ALS disease onset may occur later in patients with pre-morbid diabetes mellitus. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 17: 733-9. PMID 20074230 DOI: 10.1111/J.1468-1331.2009.02923.X |
0.33 |
|
| 2010 |
Appel SH, Beers DR, Henkel JS. T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? Trends in Immunology. 31: 7-17. PMID 19879804 DOI: 10.1016/J.It.2009.09.003 |
0.342 |
|
| 2010 |
Zhao W, Beers DR, Henkel JS, Zhang W, Urushitani M, Julien JP, Appel SH. Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia. 58: 231-43. PMID 19672969 DOI: 10.1002/Glia.20919 |
0.316 |
|
| 2009 |
Henkel JS, Beers DR, Zhao W, Appel SH. Microglia in ALS: the good, the bad, and the resting. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 389-98. PMID 19731042 DOI: 10.1007/S11481-009-9171-5 |
0.384 |
|
| 2009 |
Henkel JS, Beers DR, Wen S, Bowser R, Appel SH. Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS. Neurology. 72: 1614-6. PMID 19414730 DOI: 10.1212/Wnl.0B013E3181A41228 |
0.346 |
|
| 2009 |
Appel SH. CD4+ T cells mediate cytotoxicity in neurodegenerative diseases. The Journal of Clinical Investigation. 119: 13-5. PMID 19104142 DOI: 10.1172/Jci38096 |
0.327 |
|
| 2008 |
Sorenson EJ, Windbank AJ, Mandrekar JN, Bamlet WR, Appel SH, Armon C, Barkhaus PE, Bosch P, Boylan K, David WS, Feldman E, Glass J, Gutmann L, Katz J, King W, et al. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology. 71: 1770-5. PMID 19029516 DOI: 10.1212/01.Wnl.0000335970.78664.36 |
0.306 |
|
| 2008 |
Appel SH, Engelhardt JI, Henkel JS, Siklos L, Beers DR, Yen AA, Simpson EP, Luo Y, Carrum G, Heslop HE, Brenner MK, Popat U. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology. 71: 1326-34. PMID 18936424 DOI: 10.1212/01.Wnl.0000327668.43541.22 |
0.329 |
|
| 2008 |
Beers DR, Henkel JS, Zhao W, Wang J, Appel SH. CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proceedings of the National Academy of Sciences of the United States of America. 105: 15558-63. PMID 18809917 DOI: 10.1073/Pnas.0807419105 |
0.327 |
|
| 2008 |
Voustianiouk A, Seidel G, Panchal J, Sivak M, Czaplinski A, Yen A, Appel SH, Lange DJ. ALSFRS and appel ALS scores: discordance with disease progression. Muscle & Nerve. 37: 668-72. PMID 18288708 DOI: 10.1002/Mus.20977 |
0.326 |
|
| 2007 |
Miller R, Bradley W, Cudkowicz M, Hubble J, Meininger V, Mitsumoto H, Moore D, Pohlmann H, Sauer D, Silani V, Strong M, Swash M, Vernotica E, Cashman N, Eisen A, ... ... Appel S, et al. Phase II/III randomized trial of TCH346 in patients with ALS Neurology. 69: 776-784. PMID 17709710 DOI: 10.1212/01.Wnl.0000269676.07319.09 |
0.325 |
|
| 2007 |
Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, ... ... Appel SH, et al. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. The New England Journal of Medicine. 357: 775-88. PMID 17671248 DOI: 10.1056/Nejmoa070174 |
0.331 |
|
| 2006 |
Czaplinski A, Haverkamp LJ, Yen AA, Simpson EP, Lai EC, Appel SH. The value of database controls in pilot or futility studies in ALS. Neurology. 67: 1827-32. PMID 17130417 DOI: 10.1212/01.Wnl.0000244415.48221.81 |
0.33 |
|
| 2006 |
Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, Yen AA, Siklos L, McKercher SR, Appel SH. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 16021-6. PMID 17043238 DOI: 10.1073/Pnas.0607423103 |
0.304 |
|
| 2006 |
Czaplinski A, Yen AA, Simpson EP, Appel SH. Predictability of disease progression in amyotrophic lateral sclerosis. Muscle & Nerve. 34: 702-8. PMID 16967489 DOI: 10.1002/Mus.20658 |
0.328 |
|
| 2006 |
Czaplinski A, Yen AA, Simpson EP, Appel SH. Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing? Archives of Neurology. 63: 1139-43. PMID 16908741 DOI: 10.1001/Archneur.63.8.1139 |
0.336 |
|
| 2006 |
Czaplinski A, Yen AA, Appel SH. Amyotrophic lateral sclerosis: early predictors of prolonged survival. Journal of Neurology. 253: 1428-36. PMID 16773270 DOI: 10.1007/S00415-006-0226-8 |
0.309 |
|
| 2006 |
Goldknopf IL, Sheta EA, Bryson J, Folsom B, Wilson C, Duty J, Yen AA, Appel SH. Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease. Biochemical and Biophysical Research Communications. 342: 1034-9. PMID 16516157 DOI: 10.1016/J.Bbrc.2006.02.051 |
0.318 |
|
| 2006 |
Czaplinski A, Yen AA, Appel SH. Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population. Journal of Neurology, Neurosurgery, and Psychiatry. 77: 390-2. PMID 16484652 DOI: 10.1136/Jnnp.2005.072660 |
0.339 |
|
| 2006 |
Sheta EA, Appel SH, Goldknopf IL. 2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases. Expert Review of Proteomics. 3: 45-62. PMID 16445350 DOI: 10.1586/14789450.3.1.45 |
0.305 |
|
| 2006 |
Henkel JS, Beers DR, Siklós L, Appel SH. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS. Molecular and Cellular Neurosciences. 31: 427-37. PMID 16337133 DOI: 10.1016/J.Mcn.2005.10.016 |
0.318 |
|
| 2005 |
Yoshor D, Klugh A, Appel SH, Haverkamp LJ. Incidence and characteristics of spinal decompression surgery after the onset of symptoms of amyotrophic lateral sclerosis. Neurosurgery. 57: 984-9; discussion 98. PMID 16284567 DOI: 10.1227/01.Neu.0000180028.64385.D3 |
0.348 |
|
| 2005 |
Ringholz GM, Appel SH, Bradshaw M, Cooke NA, Mosnik DM, Schulz PE. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 65: 586-90. PMID 16116120 DOI: 10.1212/01.Wnl.0000172911.39167.B6 |
0.315 |
|
| 2005 |
Vigh L, Smith RG, Soós J, Engelhardt JI, Appel SH, Siklós L. Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo. Acta Neuropathologica. 109: 567-75. PMID 15933871 DOI: 10.1007/S00401-004-0977-1 |
0.354 |
|
| 2004 |
Trail M, Nelson N, Van JN, Appel SH, Lai EC. Major stressors facing patients with amyotrophic lateral sclerosis (ALS): a survey to identify their concerns and to compare with those of their caregivers. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 5: 40-5. PMID 15204023 DOI: 10.1080/14660820310016075 |
0.3 |
|
| 2004 |
Simpson EP, Henry YK, Henkel JS, Smith RG, Appel SH. Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. Neurology. 62: 1758-65. PMID 15159474 DOI: 10.1212/Wnl.62.10.1758 |
0.331 |
|
| 2004 |
Henkel JS, Engelhardt JI, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Annals of Neurology. 55: 221-35. PMID 14755726 DOI: 10.1002/Ana.10805 |
0.351 |
|
| 2003 |
Simpson EP, Yen AA, Appel SH. Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis. Current Opinion in Rheumatology. 15: 730-6. PMID 14569202 DOI: 10.1097/00002281-200311000-00008 |
0.336 |
|
| 2003 |
Sengun IS, Appel SH. Serum anti-Fas antibody levels in amyotrophic lateral sclerosis. Journal of Neuroimmunology. 142: 137-40. PMID 14512172 DOI: 10.1016/S0165-5728(03)00263-7 |
0.345 |
|
| 2003 |
Cudkowicz ME, Shefner JM, Schoenfeld DA, Brown RH, Johnson H, Qureshi M, Jacobs M, Rothstein JD, Appel SH, Pascuzzi RM, Heiman-Patterson TD, Donofrio PD, David WS, Russell JA, Tandan R, et al. A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology. 61: 456-64. PMID 12939417 DOI: 10.1212/Wnl.61.4.456 |
0.322 |
|
| 2003 |
Kim SH, Henkel JS, Beers DR, Sengun IS, Simpson EP, Goodman JC, Engelhardt JI, Siklós L, Appel SH. PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients. Journal of Neuropathology and Experimental Neurology. 62: 88-103. PMID 12528821 DOI: 10.1093/Jnen/62.1.88 |
0.369 |
|
| 2002 |
Mohamed HA, Mosier DR, Zou LL, Siklós L, Alexianu ME, Engelhardt JI, Beers DR, Le WD, Appel SH. Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons. Journal of Neuroscience Research. 69: 110-6. PMID 12111822 DOI: 10.1002/Jnr.10271 |
0.347 |
|
| 2001 |
Beers DR, Ho BK, Siklós L, Alexianu ME, Mosier DR, Mohamed AH, Otsuka Y, Kozovska ME, McAlhany RE, Smith RG, Appel SH. Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis. Journal of Neurochemistry. 79: 499-509. PMID 11701753 DOI: 10.1046/J.1471-4159.2001.00582.X |
0.323 |
|
| 2001 |
Alexianu ME, Kozovska M, Appel SH. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology. 57: 1282-9. PMID 11591849 DOI: 10.1212/Wnl.57.7.1282 |
0.368 |
|
| 2001 |
Appel SH, Beers D, Siklos L, Engelhardt JI, Mosier DR. Calcium: the Darth Vader of ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 2: S47-54. PMID 11465925 DOI: 10.1080/146608201300079418 |
0.342 |
|
| 2001 |
Trail M, Nelson N, Van JN, Appel SH, Lai EC. Wheelchair use by patients with amyotrophic lateral sclerosis: a survey of user characteristics and selection preferences. Archives of Physical Medicine and Rehabilitation. 82: 98-102. PMID 11239293 DOI: 10.1053/Apmr.2001.18062 |
0.306 |
|
| 2000 |
Engelhardt JI, Le WD, Siklós L, Obál I, Boda K, Appel SH. Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. Archives of Neurology. 57: 681-6. PMID 10815134 DOI: 10.1001/Archneur.57.5.681 |
0.32 |
|
| 2000 |
Siklós L, Engelhardt JI, Reaume AG, Scott RW, Adalbert R, Obál I, Appel SH. Altered calcium homeostasis in spinal motoneurons but not in oculomotor neurons of SOD-1 knockout mice. Acta Neuropathologica. 99: 517-24. PMID 10805095 DOI: 10.1007/S004010051154 |
0.311 |
|
| 2000 |
Mosier DR, Siklós L, Appel SH. Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera. Neurology. 54: 252-5. PMID 10636164 DOI: 10.1212/Wnl.54.1.252 |
0.346 |
|
| 1999 |
Siklós L, Engelhardt JI, Adalbert R, Appel SH. Calcium-containing endosomes at oculomotor terminals in animal models of ALS. Neuroreport. 10: 2539-45. PMID 10574366 DOI: 10.1097/00001756-199908200-00019 |
0.347 |
|
| 1999 |
Panzara MA, Gussoni E, Begovich AB, Murray RS, Zang YQ, Appel SH, Steinman L, Zhang J. T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurobiology of Disease. 6: 392-405. PMID 10527806 DOI: 10.1006/Nbdi.1999.0252 |
0.374 |
|
| 1998 |
Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, Kasarskis E, Mattson MP. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Annals of Neurology. 44: 819-24. PMID 9818940 DOI: 10.1002/Ana.410440518 |
0.336 |
|
| 1998 |
Smith RG, Henry YK, Mattson MP, Appel SH. Presence of 4-hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. Annals of Neurology. 44: 696-9. PMID 9778272 DOI: 10.1002/Ana.410440419 |
0.337 |
|
| 1998 |
Alexianu ME, Robbins E, Carswell S, Appel SH. 1Alpha, 25 dihydroxyvitamin D3-dependent up-regulation of calcium-binding proteins in motoneuron cells. Journal of Neuroscience Research. 51: 58-66. PMID 9452309 DOI: 10.1002/(Sici)1097-4547(19980101)51:1<58::Aid-Jnr6>3.0.Co;2-K |
0.326 |
|
| 1997 |
Engelhardt JI, Siklós L, Appel SH. Immunization of guinea pigs with human choline acetyltransferase induces selective lower motoneuron destruction. Journal of Neuroimmunology. 78: 57-68. PMID 9307228 DOI: 10.1016/S0165-5728(97)00082-9 |
0.315 |
|
| 1997 |
Colom LV, Alexianu ME, Mosier DR, Smith RG, Appel SH. Amyotrophic lateral sclerosis immunoglobulins increase intracellular calcium in a motoneuron cell line. Experimental Neurology. 146: 354-60. PMID 9270044 DOI: 10.1006/Exnr.1997.6541 |
0.338 |
|
| 1997 |
La Bella V, Goodman JC, Appel SH. Increased CSF glutamate following injection of ALS immunoglobulins. Neurology. 48: 1270-2. PMID 9153455 DOI: 10.1212/Wnl.48.5.1270 |
0.322 |
|
| 1997 |
Engelhardt JI, Siklos L, Appel SH. Altered calcium homeostasis and ultrastructure in motoneurons of mice caused by passively transferred anti-motoneuronal IgG. Journal of Neuropathology and Experimental Neurology. 56: 21-39. PMID 8990126 DOI: 10.1097/00005072-199701000-00003 |
0.321 |
|
| 1996 |
Siklós L, Engelhardt J, Harati Y, Smith RG, Joó F, Appel SH. Ultrastructural evidence for altered calcium in motor nerve terminals in amyotropic lateral sclerosis. Annals of Neurology. 39: 203-16. PMID 8967752 DOI: 10.1002/Ana.410390210 |
0.337 |
|
| 1996 |
Smith RG, Siklos L, Alexianu ME, Engelhardt JI, Mosier DR, Colom L, Habib Mohamed A, Appel SH. Autoimmunity and ALS. Neurology. 47: S40-5; discussion S4. PMID 8858050 DOI: 10.1212/Wnl.47.4_Suppl_2.40S |
0.333 |
|
| 1996 |
Ho BK, Alexianu ME, Colom LV, Mohamed AH, Serrano F, Appel SH. Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 93: 6796-801. PMID 8692898 DOI: 10.1073/Pnas.93.13.6796 |
0.357 |
|
| 1995 |
Mosier DR, Baldelli P, Delbono O, Smith RG, Alexianu ME, Appel SH, Stefani E. Amyotrophic lateral sclerosis immunoglobulins increase Ca2+ currents in a motoneuron cell line. Annals of Neurology. 37: 102-9. PMID 7818241 DOI: 10.1002/Ana.410370119 |
0.359 |
|
| 1995 |
Smith RG, Kimura F, Harati Y, McKinley K, Stefani E, Appel SH. Altered muscle calcium channel binding kinetics in autoimmune motoneuron disease. Muscle & Nerve. 18: 620-7. PMID 7753125 DOI: 10.1002/Mus.880180609 |
0.35 |
|
| 1995 |
Haverkamp LJ, Appel V, Appel SH. Natural history of amyotrophic lateral sclerosis in a database population validation of a scoring system and a model for survival prediction Brain. 118: 707-719. PMID 7600088 DOI: 10.1093/Brain/118.3.707 |
0.356 |
|
| 1995 |
Engelhardt JI, Siklós L, Kömüves L, Smith RG, Appel SH. Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons. Synapse (New York, N.Y.). 20: 185-99. PMID 7570350 DOI: 10.1002/Syn.890200302 |
0.347 |
|
| 1994 |
Smith RG, Alexianu ME, Crawford G, Nyormoi O, Stefani E, Appel SH. Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line. Proceedings of the National Academy of Sciences of the United States of America. 91: 3393-7. PMID 8159758 DOI: 10.1073/Pnas.91.8.3393 |
0.354 |
|
| 1994 |
Kimura F, Smith RG, Delbono O, Nyormoi O, Schneider T, Nastainczyk W, Hofmann F, Stefani E, Appel SH. Amyotrophic lateral sclerosis patient antibodies label Ca2+ channel alpha 1 subunit. Annals of Neurology. 35: 164-71. PMID 8109897 DOI: 10.1002/Ana.410350207 |
0.313 |
|
| 1994 |
Killian JM, Wilfong AA, Burnett L, Appel SH, Boland D. Decremental motor responses to repetitive nerve stimulation in ALS Muscle & Nerve. 17: 747-754. PMID 8008001 DOI: 10.1002/Mus.880170708 |
0.367 |
|
| 1994 |
Alexianu ME, Ho BK, Mohamed AH, La Bella V, Smith RG, Appel SH. The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis. Annals of Neurology. 36: 846-58. PMID 7998770 DOI: 10.1002/Ana.410360608 |
0.375 |
|
| 1994 |
Alexianu ME, Mohamed AH, Smith RG, Colom LV, Appel SH. Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis. Journal of Neurochemistry. 63: 2365-8. PMID 7964760 DOI: 10.1046/J.1471-4159.1994.63062365.X |
0.364 |
|
| 1993 |
Smith RG, Engelhardt JI, Tajti J, Appel SH. Experimental immune-mediated motor neuron diseases: models for human ALS. Brain Research Bulletin. 30: 373-80. PMID 8457886 DOI: 10.1016/0361-9230(93)90268-G |
0.341 |
|
| 1993 |
Delbono O, Magnelli V, Sawada T, Smith RG, Appel SH, Stefani E. Fab fragments from amyotrophic lateral sclerosis IgG affect calcium channels of skeletal muscle. The American Journal of Physiology. 264: C537-43. PMID 8384783 DOI: 10.1152/Ajpcell.1993.264.3.C537 |
0.323 |
|
| 1993 |
Llinás R, Sugimori M, Cherksey BD, Smith RG, Delbono O, Stefani E, Appel S. IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. 90: 11743-7. PMID 8265620 DOI: 10.1073/Pnas.90.24.11743 |
0.326 |
|
| 1993 |
Appel SH, Smith RG, Engelhardt JI, Stefani E. Evidence for autoimmunity in amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 118: 169-74. PMID 8229065 DOI: 10.1016/0022-510X(93)90106-9 |
0.374 |
|
| 1993 |
Engelhardt JI, Tajti J, Appel SH. Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis Jama Neurology. 50: 30-36. PMID 8093428 DOI: 10.1001/Archneur.1993.00540010026013 |
0.33 |
|
| 1992 |
Uchitel OD, Scornik F, Protti DA, Fumberg CG, Alvarez V, Appel SH. Long-term neuromuscular dysfunction produced by passive transfer of amyotrophic lateral sclerosis immunoglobulins. Neurology. 42: 2175-80. PMID 1436531 DOI: 10.1212/Wnl.42.11.2175 |
0.362 |
|
| 1992 |
Smith RG, Hamilton S, Hofmann F, Schneider T, Nastainczyk W, Birnbaumer L, Stefani E, Appel SH. Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. The New England Journal of Medicine. 327: 1721-8. PMID 1331790 DOI: 10.1056/Nejm199212103272405 |
0.351 |
|
| 1991 |
Appel SH, Engelhardt JI, GarcÃa J, Stefani E. Immunoglobulins from animal models of motor neuron disease and from human amyotrophic lateral sclerosis patients passively transfer physiological abnormalities to the neuromuscular junction. Proceedings of the National Academy of Sciences of the United States of America. 88: 647-51. PMID 1988960 DOI: 10.1073/Pnas.88.2.647 |
0.378 |
|
| 1991 |
Tajti J, Stefani E, Appel SH. Cyclophosphamide alters the clinical and pathological expression of experimental autoimmune gray matter disease. Journal of Neuroimmunology. 34: 143-51. PMID 1918320 DOI: 10.1016/0165-5728(91)90123-O |
0.329 |
|
| 1991 |
Delbono O, GarcÃa J, Appel SH, Stefani E. Calcium current and charge movement of mammalian muscle: action of amyotrophic lateral sclerosis immunoglobulins. The Journal of Physiology. 444: 723-42. PMID 1668354 DOI: 10.1113/Jphysiol.1991.Sp018903 |
0.345 |
|
| 1991 |
Delbono O, GarcÃa J, Appel SH, Stefani E. IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscle. The American Journal of Physiology. 260: C1347-51. PMID 1647668 DOI: 10.1152/Ajpcell.1991.260.6.C1347 |
0.341 |
|
| 1991 |
Appel SH, Engelhardt JI, Smith R, Delbono O, Stefani E. ALS as an autoimmune disease Journal of Neuroimmunology. 35: 78. DOI: 10.1016/0165-5728(91)90982-D |
0.341 |
|
| 1990 |
Appel SH, Engelhardt JI, Jakob K. An animal model of motor neuron disease in guinea pigs. Progress in Brain Research. 84: 381-387. PMID 2267309 DOI: 10.1016/S0079-6123(08)60921-8 |
0.321 |
|
| 1990 |
GarcÃa J, Engelhardt JI, Appel SH, Stefani E. Increased MEPP frequency as an early sign of experimental immune-mediated motoneuron disease. Annals of Neurology. 28: 329-34. PMID 2241116 DOI: 10.1002/Ana.410280305 |
0.301 |
|
| 1990 |
Engelhardt JI, Appel SH. Igg Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis Archives of Neurology. 47: 1210-1216. PMID 2122877 DOI: 10.1001/Archneur.1990.00530110068019 |
0.339 |
|
| 1990 |
Engelhardt J, Appel SH. Motor neuron reactivity of sera from animals with autoimmune models of motor neuron destruction Journal of the Neurological Sciences. 96: 333-352. PMID 1695918 DOI: 10.1016/0022-510X(90)90143-B |
0.332 |
|
| 1990 |
Engelhardt JI, Appel SH, Killian JM. Motor neuron destruction in guinea pigs immunized with bovine spinal cord ventral horn homogenate : experimental autoimmune gray matter disease Journal of Neuroimmunology. 27: 21-31. PMID 1690752 DOI: 10.1016/0165-5728(90)90132-7 |
0.338 |
|
| 1989 |
Iwasaki Y, Kinoshita M, Ikeda K, Appel SH, Stewart SS. Trophic effects of skeletal muscle extracts on spinal cord cultures. International Journal of Neuroscience. 47: 203-208. PMID 2807759 DOI: 10.3109/00207458908987434 |
0.315 |
|
| 1989 |
Engelhardt JI, Appel SH, Killian JM. Experimental autoimmune motoneuron disease. Annals of Neurology. 26: 368-376. PMID 2802536 DOI: 10.1002/Ana.410260310 |
0.318 |
|
| 1988 |
Stewart SS, Appel SH. Trophic factors in neurologic disease Annual Review of Medicine. 39: 193-201. PMID 3285771 DOI: 10.1146/Annurev.Me.39.020188.001205 |
0.319 |
|
| 1988 |
Uchitel OD, Appel SH, Crawford F, Sczcupak L. Immunoglobulins from amyotrophic lateral sclerosis patients enhance spontaneous transmitter release from motor-nerve terminals. Proceedings of the National Academy of Sciences of the United States of America. 85: 7371-4. PMID 2902629 DOI: 10.1073/Pnas.85.19.7371 |
0.386 |
|
| 1987 |
Appel V, Stewart SS, Smith G, Appel SH. A rating scale for amyotrophic lateral sclerosis: Description and preliminary experience Annals of Neurology. 22: 328-333. PMID 3118763 DOI: 10.1002/Ana.410220308 |
0.322 |
|
| 1986 |
Smith RG, Vaca K, McManaman J, Appel SH. Selective effects of skeletal muscle extract fractions on motoneuron development in vitro Journal of Neuroscience. 6: 439-447. PMID 3754005 DOI: 10.1523/Jneurosci.06-02-00439.1986 |
0.305 |
|
| 1986 |
Appel SH, Stockton-Appel V, Stewart SS, Kerman RH. Amyotrophic lateral sclerosis. Associated clinical disorders and immunological evaluations. Jama Neurology. 43: 234-238. PMID 3484947 DOI: 10.1001/Archneur.1986.00520030026007 |
0.362 |
|
| 1986 |
Appel SH, McManaman JL. Is a breakdown of the blood-brain barrier cause or effect? Neurobiology of Aging. 7: 512-514. DOI: 10.1016/0197-4580(86)90094-1 |
0.317 |
|
| 1983 |
Smith RG, Appel SH. Extracts of skeletal muscle increase neurite outgrowth and cholinergic activity of fetal rat spinal motor neurons Science. 219: 1079-1081. PMID 6823568 DOI: 10.1126/Science.6823568 |
0.303 |
|
| 1981 |
Merickel M, Gray R, Chauvin P, Appel S. Cultured muscle from myotonic muscular dystrophy patients: Altered membrane electrical properties Proceedings of the National Academy of Sciences of the United States of America. 78: 648-652. PMID 6941262 DOI: 10.1073/Pnas.78.1.648 |
0.3 |
|
| 1981 |
Appel SH. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, Parkinsonism, and Alzheimer disease Annals of Neurology. 10: 499-505. PMID 6173010 DOI: 10.1002/Ana.410100602 |
0.346 |
|
| 1978 |
Appel SH, Ryan AJ. Demyelinative and degenerative diseases of the nervous system. Postgraduate Medicine. 64: 81-81. PMID 27452356 DOI: 10.1080/00325481.1978.11714900 |
0.302 |
|
| 1975 |
Appel SH, Almon RR, Levy N. Acetylcholine receptor antibodies in myasthenia gravis. The New England Journal of Medicine. 293: 760-761. PMID 1160955 DOI: 10.1056/Nejm197510092931508 |
0.305 |
|
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