| Year |
Citation |
Score |
| 2022 |
Roberts AG, Stevens JC, Szklarz GD, Scott EE, Kumar S, Shah MB, Halpert JR. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 36310033 DOI: 10.1124/dmd.122.001109 |
0.639 |
|
| 2022 |
Skopec MM, Halpert JR, Dearing MD. Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences. Advances in Pharmacology (San Diego, Calif.). 95: 107-129. PMID 35953153 DOI: 10.1016/bs.apha.2022.05.002 |
0.351 |
|
| 2020 |
Halpert JR. So many roads traveled: A career in science and administration. The Journal of Biological Chemistry. 295: 822-832. PMID 31953248 DOI: 10.1074/jbc.X119.012206 |
0.341 |
|
| 2018 |
Shah MB, Zhang Q, Halpert JR. Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog. International Journal of Molecular Sciences. 19. PMID 29596329 DOI: 10.3390/Ijms19041025 |
0.349 |
|
| 2018 |
Chen C, Liu J, Wilderman PR, Halpert JR. Structure-activity relationship of phenoxyaniline congener interactions with cytochrome P450 2B enzymes Drug Metabolism and Pharmacokinetics. 33: S75. DOI: 10.1016/j.dmpk.2017.11.247 |
0.45 |
|
| 2017 |
Chen C, Liu J, Halpert JR, Wilderman PR. Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes. Biochemistry. PMID 29215266 DOI: 10.1021/acs.biochem.7b01024 |
0.374 |
|
| 2017 |
Huo L, Liu J, Szklarz GD, Dearing D, Halpert JR, Wilderman PR. Rational Re-Engineering of the Oxidation of 7-Alkoxycoumarin Derivatives by Cytochromes P450 2B from the Desert Woodrat Neotoma lepida. Biochemistry. PMID 28375626 DOI: 10.1021/Acs.Biochem.7B00097 |
0.394 |
|
| 2017 |
Shah MB, Liu J, Zhang Q, Stout CD, Halpert JR. Halogen-π Interactions in the Cytochrome P450 Active Site: Structural Insights into Human CYP2B6 Substrate Selectivity. Acs Chemical Biology. PMID 28368100 DOI: 10.1021/Acschembio.7B00056 |
0.412 |
|
| 2016 |
Müller CS, Knehans T, Davydov DR, Bounds PL, von Mandach U, Halpert JR, Caflisch A, Koppenol WH. Correction to Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations. Biochemistry. PMID 27650703 DOI: 10.1021/acs.biochem.6b00904 |
0.345 |
|
| 2016 |
Shah MB, Jang HH, Wilderman PR, Lee D, Li S, Zhang Q, Stout CD, Halpert JR. Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. Biophysical Chemistry. 216: 1-8. PMID 27280734 DOI: 10.1016/J.Bpc.2016.05.007 |
0.348 |
|
| 2016 |
Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. PMID 26982502 DOI: 10.1021/Acs.Biochem.5B01330 |
0.43 |
|
| 2016 |
Shah MB, Liu J, Huo L, Zhang Q, Dearing MD, Wilderman PR, Szklarz GD, Stout CD, Halpert JR. Structure-Function Analysis of Mammalian CYP2B Enzymes using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism. Molecular Pharmacology. PMID 26826176 DOI: 10.1124/Mol.115.102111 |
0.37 |
|
| 2015 |
Jang HH, Liu J, Lee GY, Halpert JR, Wilderman PR. Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes. Archives of Biochemistry and Biophysics. 584: 61-69. PMID 26319176 DOI: 10.1016/j.abb.2015.08.007 |
0.382 |
|
| 2015 |
Shah MB, Wilderman PR, Liu J, Jang HH, Zhang Q, Stout CD, Halpert JR. Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison. Molecular Pharmacology. 87: 649-59. PMID 25585967 DOI: 10.1124/Mol.114.097014 |
0.398 |
|
| 2015 |
Müller CS, Knehans T, Davydov DR, Bounds PL, von Mandach U, Halpert JR, Caflisch A, Koppenol WH. Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations. Biochemistry. 54: 711-21. PMID 25545162 DOI: 10.1021/Bi5011656 |
0.383 |
|
| 2015 |
Davydov DR, Davydova NY, Sineva EV, Halpert JR. Interactions among cytochromes P450 in microsomal membranes: Oligomerization of cytochromes P4503A4,3A5, and 2E1 and its functional consequences Journal of Biological Chemistry. 290: 3850-3868. PMID 25533469 DOI: 10.1074/jbc.M114.615443 |
0.439 |
|
| 2014 |
Jang HH, Davydov DR, Lee GY, Yun CH, Halpert JR. The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes. Archives of Biochemistry and Biophysics. 545: 100-7. PMID 24445070 DOI: 10.1016/j.abb.2014.01.008 |
0.511 |
|
| 2014 |
Wilderman PR, Jang HH, Malenke JR, Salib M, Angermeier E, Lamime S, Dearing MD, Halpert JR. Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida. Toxicology and Applied Pharmacology. 274: 393-401. PMID 24361551 DOI: 10.1016/J.Taap.2013.12.005 |
0.453 |
|
| 2013 |
Sineva EV, Rumfeldt JAO, Halpert JR, Davydov DR. A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET) Plos One. 8. PMID 24376769 DOI: 10.1371/journal.pone.0083898 |
0.321 |
|
| 2013 |
Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR. Structural and thermodynamic basis of (+)-α-pinene binding to human cytochrome P450 2B6. Journal of the American Chemical Society. 135: 10433-40. PMID 23786449 DOI: 10.1021/ja403042k |
0.473 |
|
| 2013 |
Davydov DR, Davydova NY, Sineva EV, Kufareva I, Halpert JR. Pivotal role of P450-P450 interactions in CYP3A4 allostery: The case of α-naphthoflavone Biochemical Journal. 453: 219-230. PMID 23651100 DOI: 10.1042/BJ20130398 |
0.405 |
|
| 2013 |
Shah MB, Kufareva I, Pascual J, Zhang Q, Stout CD, Halpert JR. A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states. The Journal of Pharmacology and Experimental Therapeutics. 346: 113-20. PMID 23633618 DOI: 10.1124/Jpet.113.204776 |
0.313 |
|
| 2013 |
Davydov DR, Sineva EV, Davydova NY, Bartlett DH, Halpert JR. CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450. Biotechnology and Applied Biochemistry. 60: 30-40. PMID 23586990 DOI: 10.1002/Bab.1083 |
0.332 |
|
| 2013 |
Shah MB, Jang HH, Zhang Q, David Stout C, Halpert JR. X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocket. Archives of Biochemistry and Biophysics. 530: 64-72. PMID 23296089 DOI: 10.1016/J.Abb.2012.12.016 |
0.457 |
|
| 2013 |
Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome P450 catalysis Biochemistry. 52: 355-364. PMID 23276288 DOI: 10.1021/Bi301567Z |
0.68 |
|
| 2012 |
Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 51: 7225-38. PMID 22909231 DOI: 10.1021/Bi300894Z |
0.488 |
|
| 2012 |
Wilderman PR, Halpert JR. Plasticity of CYP2B enzymes: structural and solution biophysical methods. Current Drug Metabolism. 13: 167-76. PMID 22208531 DOI: 10.2174/138920012798918417 |
0.355 |
|
| 2012 |
Davydov DR, Rumfeldt JAO, Sineva EV, Fernando H, Davydova NY, Halpert JR. Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET) Journal of Biological Chemistry. 287: 6797-6809. PMID 22194603 DOI: 10.1074/jbc.M111.325654 |
0.391 |
|
| 2012 |
Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme. The Febs Journal. 279: 1607-20. PMID 22051155 DOI: 10.1111/J.1742-4658.2011.08411.X |
0.709 |
|
| 2012 |
Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. Correction to The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4 Biochemistry. 51: 1332-1332. DOI: 10.1021/Bi300045B |
0.309 |
|
| 2011 |
Roberts AG, Yang J, Halpert JR, Nelson SD, Thummel KT, Atkins WM. The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4. Biochemistry. 50: 10804-18. PMID 21992114 DOI: 10.1021/Bi200924T |
0.324 |
|
| 2011 |
Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. Molecular Pharmacology. 80: 1047-55. PMID 21875942 DOI: 10.1124/Mol.111.074427 |
0.546 |
|
| 2011 |
Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL, Stout CD, Hollenberg PF, Halpert JR. Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry. 50: 4903-11. PMID 21510666 DOI: 10.1021/Bi200482G |
0.708 |
|
| 2011 |
Halpert JR. Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and back. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1113-21. PMID 21502194 DOI: 10.1124/dmd.111.039719 |
0.441 |
|
| 2011 |
Roberts AG, Sjögren SE, Fomina N, Vu KT, Almutairi A, Halpert JR. NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylation. Biochemistry. 50: 2123-34. PMID 21375273 DOI: 10.1021/Bi101797V |
0.45 |
|
| 2011 |
Talakad JC, Shah MB, Walker GS, Xiang C, Halpert JR, Dalvie D. Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 539-50. PMID 21156812 DOI: 10.1124/dmd.110.037101 |
0.309 |
|
| 2011 |
Fernando H, Rumfeldt JA, Davydova NY, Halpert JR, Davydov DR. Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 281-9. PMID 21143007 DOI: 10.3109/00498254.2010.538748 |
0.31 |
|
| 2010 |
Gay SC, Roberts AG, Halpert JR. Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR. Future Medicinal Chemistry. 2: 1451-68. PMID 21103389 |
0.653 |
|
| 2010 |
Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL, Stout CD, Halpert JR. Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. The Journal of Biological Chemistry. 285: 38602-11. PMID 20880847 DOI: 10.1074/Jbc.M110.180646 |
0.472 |
|
| 2010 |
Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel . Biochemistry. 49: 8709-20. PMID 20815363 DOI: 10.1021/Bi100914Z |
0.695 |
|
| 2010 |
Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Molecular Pharmacology. 77: 529-38. PMID 20061448 DOI: 10.1124/Mol.109.062570 |
0.701 |
|
| 2010 |
Davydov DR, Sineva EV, Sistla S, Davydova NY, Frank DJ, Sligar SG, Halpert JR. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochimica Et Biophysica Acta. 1797: 378-90. PMID 20026040 DOI: 10.1016/J.Bbabio.2009.12.008 |
0.348 |
|
| 2010 |
Talakad JC, Wilderman PR, Davydov DR, Kumar S, Halpert JR. Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334. Archives of Biochemistry and Biophysics. 494: 151-8. PMID 19944064 DOI: 10.1016/j.abb.2009.11.026 |
0.455 |
|
| 2009 |
Gay SC, Sun L, Maekawa K, Halpert JR, Stout CD. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning. Biochemistry. 48: 4762-71. PMID 19397311 DOI: 10.1021/bi9003765 |
0.652 |
|
| 2009 |
Sun H, Moore C, Dansette PM, Kumar S, Halpert JR, Yost GS. Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 672-84. PMID 19074530 DOI: 10.1124/Dmd.108.022707 |
0.341 |
|
| 2009 |
Talakad JC, Kumar S, Halpert JR. Decreased susceptibility of the cytochrome P450 2B6 variant K262R to inhibition by several clinically important drugs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 644-50. PMID 19074527 DOI: 10.1124/dmd.108.023655 |
0.386 |
|
| 2008 |
Davydov DR, Halpert JR. Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both? Expert Opinion On Drug Metabolism & Toxicology. 4: 1523-35. PMID 19040328 DOI: 10.1517/17425250802500028 |
0.438 |
|
| 2008 |
Oezguen N, Kumar S, Hindupur A, Braun W, Muralidhara BK, Halpert JR. Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes. The Journal of Biological Chemistry. 283: 21808-16. PMID 18495666 DOI: 10.1074/Jbc.M708582200 |
0.319 |
|
| 2008 |
Muralidhara BK, Sun L, Negi S, Halpert JR. Thermodynamic fidelity of the mammalian cytochrome P450 2B4 active site in binding substrates and inhibitors. Journal of Molecular Biology. 377: 232-45. PMID 18241887 DOI: 10.1016/J.Jmb.2007.12.068 |
0.474 |
|
| 2008 |
Davydov DR, Davydova NY, Tsalkova TN, Halpert JR. Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4. Archives of Biochemistry and Biophysics. 471: 134-45. PMID 18206979 DOI: 10.1016/J.Abb.2008.01.001 |
0.44 |
|
| 2008 |
Fernando H, Halpert JR, Davydov DR. Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. Archives of Biochemistry and Biophysics. 471: 20-31. PMID 18086551 DOI: 10.1016/J.Abb.2007.11.020 |
0.434 |
|
| 2008 |
Talakad JC, Sun L, Kumar S, Halpert JR. Characterization of the P450 2B6 genetic variant K262R for temperature stability and drug binding The Faseb Journal. 22: 653-653. DOI: 10.1096/FASEBJ.22.2_SUPPLEMENT.653 |
0.302 |
|
| 2007 |
Pearson JT, Wahlstrom JL, Dickmann LJ, Kumar S, Halpert JR, Wienkers LC, Foti RS, Rock DA. Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediates. Chemical Research in Toxicology. 20: 1778-86. PMID 18001057 DOI: 10.1021/Tx700207U |
0.43 |
|
| 2007 |
Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4. Biochemistry. 46: 11559-67. PMID 17887776 DOI: 10.1021/Bi7011614 |
0.527 |
|
| 2007 |
Muralidhara BK, Halpert JR. Thermodynamics of ligand binding to P450 2B4 and P450eryF studied by isothermal titration calorimetry. Drug Metabolism Reviews. 39: 539-56. PMID 17786637 DOI: 10.1080/03602530701498182 |
0.538 |
|
| 2007 |
Kumar S, Zhao Y, Sun L, Negi SS, Halpert JR, Muralidhara BK. Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: Importance of a Leu264→Phe substitution Molecular Pharmacology. 72: 1191-1199. PMID 17715394 DOI: 10.1124/Mol.107.039693 |
0.6 |
|
| 2007 |
Davydov DR, Baas BJ, Sligar SG, Halpert JR. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket. Biochemistry. 46: 7852-64. PMID 17555301 DOI: 10.1021/Bi602400Y |
0.404 |
|
| 2007 |
Fernando H, Davydov DR, Chin CC, Halpert JR. Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. Archives of Biochemistry and Biophysics. 460: 129-40. PMID 17274942 DOI: 10.1016/J.Abb.2006.12.025 |
0.484 |
|
| 2007 |
Sun L, Chen CS, Waxman DJ, Liu H, Halpert JR, Kumar S. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Archives of Biochemistry and Biophysics. 458: 167-74. PMID 17254539 DOI: 10.1016/J.Abb.2006.12.021 |
0.415 |
|
| 2007 |
Zhao Y, Halpert JR. Structure-function analysis of cytochromes P450 2B. Biochimica Et Biophysica Acta. 1770: 402-12. PMID 16935426 DOI: 10.1016/J.Bbagen.2006.07.006 |
0.552 |
|
| 2006 |
Kumar S, Sun L, Liu H, Muralidhara BK, Halpert JR. Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. Protein Engineering, Design & Selection : Peds. 19: 547-54. PMID 17050590 DOI: 10.1093/Protein/Gzl042 |
0.431 |
|
| 2006 |
Hernandez CE, Kumar S, Liu H, Halpert JR. Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme Archives of Biochemistry and Biophysics. 455: 61-67. PMID 17027909 DOI: 10.1016/J.Abb.2006.08.024 |
0.52 |
|
| 2006 |
Kumar S, Liu H, Halpert JR. Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1958-65. PMID 16987939 DOI: 10.1124/dmd.106.012054 |
0.386 |
|
| 2006 |
Davydov DR, Fernando H, Halpert JR. Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450. Biophysical Chemistry. 123: 95-101. PMID 16701937 DOI: 10.1016/J.Bpc.2006.04.007 |
0.447 |
|
| 2006 |
Mast N, Murtazina D, Liu H, Graham SE, Bjorkhem I, Halpert JR, Peterson J, Pikuleva IA. Distinct binding of cholesterol and 5β-cholestane-3α,7α, 12α-triol to cytochrome P450 27A1: Evidence from modeling and site-directed mutagenesis studies Biochemistry. 45: 4396-4404. PMID 16584175 DOI: 10.1021/Bi052654W |
0.401 |
|
| 2006 |
Fernando H, Halpert JR, Davydov DR. Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration. Biochemistry. 45: 4199-209. PMID 16566594 DOI: 10.1021/bi052491b |
0.325 |
|
| 2006 |
Muralidhara BK, Negi S, Chin CC, Braun W, Halpert JR. Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling. The Journal of Biological Chemistry. 281: 8051-61. PMID 16439365 DOI: 10.1074/Jbc.M509696200 |
0.484 |
|
| 2006 |
Zhao Y, White MA, Muralidhara BK, Sun L, Halpert JR, Stout CD. Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction. The Journal of Biological Chemistry. 281: 5973-81. PMID 16373351 DOI: 10.1074/Jbc.M511464200 |
0.581 |
|
| 2005 |
Davydov DR, Fernando H, Baas BJ, Sligar SG, Halpert JR. Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization. Biochemistry. 44: 13902-13. PMID 16229479 DOI: 10.1021/Bi0509346 |
0.443 |
|
| 2005 |
Kumar S, Halpert JR. Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts. Biochemical and Biophysical Research Communications. 338: 456-64. PMID 16126165 DOI: 10.1016/J.Bbrc.2005.08.080 |
0.52 |
|
| 2005 |
Kumar S, Davydov DR, Halpert JR. Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1131-6. PMID 15870379 DOI: 10.1124/dmd.105.004606 |
0.45 |
|
| 2005 |
Davydov DR, Botchkareva AE, Davydova NE, Halpert JR. Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe. Biophysical Journal. 89: 418-32. PMID 15834000 DOI: 10.1529/Biophysj.104.058479 |
0.412 |
|
| 2005 |
Li W, Liu H, Scott EE, Gräter F, Halpert JR, Luo X, Shen J, Jiang H. Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 910-9. PMID 15821040 DOI: 10.1124/Dmd.105.004200 |
0.67 |
|
| 2005 |
Kumar S, Chen CS, Waxman DJ, Halpert JR. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. The Journal of Biological Chemistry. 280: 19569-75. PMID 15774478 DOI: 10.1074/Jbc.M500158200 |
0.436 |
|
| 2005 |
Honma W, Li W, Liu H, Scott EE, Halpert JR. Functional role of residues in the helix B' region of cytochrome P450 2B1. Archives of Biochemistry and Biophysics. 435: 157-65. PMID 15680917 DOI: 10.1016/J.Abb.2004.12.014 |
0.736 |
|
| 2005 |
Scott EE, Halpert JR. Structures of cytochrome P450 3A4. Trends in Biochemical Sciences. 30: 5-7. PMID 15653318 DOI: 10.1016/J.Tibs.2004.11.004 |
0.685 |
|
| 2005 |
Gupta RP, He YA, Patrick KS, Halpert JR, Bell NH. CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. The Journal of Clinical Endocrinology and Metabolism. 90: 1210-9. PMID 15546903 DOI: 10.1210/Jc.2004-0966 |
0.341 |
|
| 2004 |
Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. Molecular Pharmacology. 65: 1278-85. PMID 15102956 DOI: 10.1124/Mol.65.5.1278 |
0.487 |
|
| 2004 |
Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding. The Journal of Biological Chemistry. 279: 27294-301. PMID 15100217 DOI: 10.1074/Jbc.M403349200 |
0.732 |
|
| 2004 |
Scott EE, Liu H, Qun He Y, Li W, Halpert JR. Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix. Archives of Biochemistry and Biophysics. 423: 266-76. PMID 15001391 DOI: 10.1016/J.Abb.2003.12.035 |
0.713 |
|
| 2004 |
Yamaguchi Y, Khan KK, He YA, He YQ, Halpert JR. Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 155-61. PMID 14709633 DOI: 10.1124/dmd.32.1.155 |
0.449 |
|
| 2003 |
Davydov DR, Halpert JR, Renaud JP, Hui Bon Hoa G. Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy. Biochemical and Biophysical Research Communications. 312: 121-30. PMID 14630029 DOI: 10.1016/J.Bbrc.2003.09.247 |
0.488 |
|
| 2003 |
Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 100: 13196-201. PMID 14563924 DOI: 10.1073/Pnas.2133986100 |
0.725 |
|
| 2003 |
Kumar S, Scott EE, Liu H, Halpert JR. A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5. The Journal of Biological Chemistry. 278: 17178-84. PMID 12609983 DOI: 10.1074/Jbc.M212515200 |
0.675 |
|
| 2003 |
Spatzenegger M, Liu H, Wang Q, Debarber A, Koop DR, Halpert JR. Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling. The Journal of Pharmacology and Experimental Therapeutics. 304: 477-87. PMID 12490624 DOI: 10.1124/Jpet.102.043323 |
0.526 |
|
| 2003 |
He YA, Roussel F, Halpert JR. Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling. Archives of Biochemistry and Biophysics. 409: 92-101. PMID 12464248 DOI: 10.1016/S0003-9861(02)00484-8 |
0.456 |
|
| 2002 |
Scott EE, He YQ, Halpert JR. Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1. Chemical Research in Toxicology. 15: 1407-13. PMID 12437331 DOI: 10.1021/Tx020057U |
0.715 |
|
| 2002 |
Khan KK, He YQ, Correia MA, Halpert JR. Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 985-90. PMID 12167563 |
0.357 |
|
| 2002 |
Khan KK, He YA, He YQ, Halpert JR. Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site. Chemical Research in Toxicology. 15: 843-53. PMID 12067252 |
0.377 |
|
| 2002 |
Khan KK, Halpert JR. 7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe. Chemical Research in Toxicology. 15: 806-14. PMID 12067248 |
0.332 |
|
| 2002 |
Davydov DR, Kumar S, Halpert JR. Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate. Biochemical and Biophysical Research Communications. 294: 806-12. PMID 12061778 DOI: 10.1016/S0006-291X(02)00565-X |
0.351 |
|
| 2002 |
Khan KK, He YQ, Domanski TL, Halpert JR. Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation. Molecular Pharmacology. 61: 495-506. PMID 11854429 DOI: 10.1124/Mol.61.3.495 |
0.472 |
|
| 2002 |
Wang Q, Halpert JR. Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 86-95. PMID 11744616 |
0.386 |
|
| 2002 |
Hustert E, Haberl M, Burk O, Wolbold R, He YQ, Klein K, Nuessler AC, Neuhaus P, Klattig J, Eiselt R, Koch I, Zibat A, Brockmöller J, Halpert JR, Zanger UM, et al. The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics. 11: 773-9. PMID 11740341 DOI: 10.1097/00008571-200112000-00005 |
0.347 |
|
| 2001 |
Scott EE, Spatzenegger M, Halpert JR. A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function Archives of Biochemistry and Biophysics. 395: 57-68. PMID 11673866 DOI: 10.1006/Abbi.2001.2574 |
0.691 |
|
| 2001 |
Domanski TL, He YQ, Scott EE, Wang Q, Halpert JR. The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins Archives of Biochemistry and Biophysics. 394: 21-28. PMID 11566023 DOI: 10.1006/Abbi.2001.2504 |
0.707 |
|
| 2001 |
Domanski TL, He YA, Khan KK, Roussel F, Wang Q, Halpert JR. Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity. Biochemistry. 40: 10150-60. PMID 11513592 DOI: 10.1021/Bi010758A |
0.457 |
|
| 2001 |
Eiselt R, Domanski TL, Zibat A, Mueller R, Presecan-Siedel E, Hustert E, Zanger UM, Brockmoller J, Klenk HP, Meyer UA, Khan KK, He YA, Halpert JR, Wojnowski L. Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics. 11: 447-58. PMID 11470997 DOI: 10.1097/00008571-200107000-00008 |
0.366 |
|
| 2001 |
Domanski TL, Halpert JR. Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis. Current Drug Metabolism. 2: 117-37. PMID 11469721 DOI: 10.2174/1389200013338612 |
0.514 |
|
| 2001 |
Xue L, Wang HF, Wang Q, Szklarz GD, Domanski TL, Halpert JR, Correia MA. Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation. Chemical Research in Toxicology. 14: 483-91. PMID 11368545 DOI: 10.1021/Tx000218Z |
0.38 |
|
| 2001 |
He YQ, Roussel F, Halpert JR. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes. Archives of Biochemistry and Biophysics. 389: 264-70. PMID 11339816 DOI: 10.1006/Abbi.2001.2342 |
0.404 |
|
| 2001 |
Spatzenegger M, Wang Q, He YQ, Wester MR, Johnson EF, Halpert JR. Amino acid residues critical for differential inhibition of CYP2B4, CYP2B5, and CYP2B1 by phenylimidazoles. Molecular Pharmacology. 59: 475-84. PMID 11179442 DOI: 10.1124/Mol.59.3.475 |
0.339 |
|
| 2001 |
Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Molecular Pharmacology. 59: 386-92. PMID 11160876 DOI: 10.1124/Mol.59.2.386 |
0.399 |
|
| 2000 |
Roussel F, Khan KK, Halpert JR. The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4. Archives of Biochemistry and Biophysics. 374: 269-78. PMID 10666307 DOI: 10.1006/Abbi.1999.1599 |
0.444 |
|
| 2000 |
Ourlin JC, Baader M, Fraser D, Halpert JR, Meyer UA. Cloning and functional expression of a first inducible avian cytochrome P450 of the CYP3A subfamily (CYP3A37). Archives of Biochemistry and Biophysics. 373: 375-84. PMID 10620362 DOI: 10.1006/Abbi.1999.1566 |
0.421 |
|
| 2000 |
Khan KK, Halpert JR. Structure-function analysis of human cytochrome P450 3A4 using 7-alkoxycoumarins as active-site probes. Archives of Biochemistry and Biophysics. 373: 335-45. PMID 10620357 DOI: 10.1006/Abbi.1999.1578 |
0.543 |
|
| 1999 |
Waller SC, He YA, Harlow GR, He YQ, Mash EA, Halpert JR. 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11. Chemical Research in Toxicology. 12: 690-9. PMID 10458702 DOI: 10.1021/Tx990030J |
0.508 |
|
| 1999 |
Fraser DJ, He YQ, Harlow GR, Halpert JR. Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26. Molecular Pharmacology. 55: 241-7. PMID 9927614 DOI: 10.1124/Mol.55.2.241 |
0.332 |
|
| 1998 |
Badger D, Kraner J, Fraser D, Hoglen N, Halpert J, Sipes IG. Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol. Life Sciences. 63: PL367-72. PMID 9870717 DOI: 10.1016/S0024-3205(98)00516-5 |
0.351 |
|
| 1998 |
Wang H, Dick R, Yin H, Licad-Coles E, Kroetz DL, Szklarz G, Harlow G, Halpert JR, Correia MA. Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe. Biochemistry. 37: 12536-45. PMID 9730826 DOI: 10.1021/Bi980895G |
0.365 |
|
| 1998 |
Harlow GR, Halpert JR. Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics. Proceedings of the National Academy of Sciences of the United States of America. 95: 6636-41. PMID 9618464 DOI: 10.1073/Pnas.95.12.6636 |
0.52 |
|
| 1998 |
Kobayashi Y, Fang X, Szklarz GD, Halpert JR. Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants. Biochemistry. 37: 6679-88. PMID 9578551 DOI: 10.1021/Bi9731450 |
0.396 |
|
| 1998 |
He YQ, Harlow GR, Szklarz GD, Halpert JR. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues. Archives of Biochemistry and Biophysics. 350: 333-9. PMID 9473309 DOI: 10.1006/Abbi.1997.0516 |
0.569 |
|
| 1998 |
Domanski TL, Liu J, Harlow GR, Halpert JR. Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation. Archives of Biochemistry and Biophysics. 350: 223-32. PMID 9473295 DOI: 10.1006/Abbi.1997.0525 |
0.444 |
|
| 1998 |
Szklarz GD, Halpert JR. Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450. Life Sciences. 61: 2507-20. PMID 9416773 DOI: 10.1016/S0024-3205(97)00717-0 |
0.538 |
|
| 1997 |
Fang X, Kobayashi Y, Halpert JR. Stoichiometry of 7-ethoxycoumarin metabolism by cytochrome P450 2B1 wild-type and five active-site mutants. Febs Letters. 416: 77-80. PMID 9369237 DOI: 10.1016/S0014-5793(97)01173-3 |
0.552 |
|
| 1997 |
Kent UM, Hanna IH, Szklarz GD, Vaz AD, Halpert JR, Bend JR, Hollenberg PF. Significance of glycine 478 in the metabolism of N-benzyl-1-aminobenzotriazole to reactive intermediates by cytochrome P450 2B1. Biochemistry. 36: 11707-16. PMID 9305960 DOI: 10.1021/Bi971064Y |
0.555 |
|
| 1997 |
Strobel SM, Halpert JR. Reassessment of cytochrome P450 2B2: catalytic specificity and identification of four active site residues. Biochemistry. 36: 11697-706. PMID 9305959 DOI: 10.1021/BI9710176 |
0.422 |
|
| 1997 |
Szklarz GD, Halpert JR. Molecular modeling of cytochrome P450 3A4. Journal of Computer-Aided Molecular Design. 11: 265-72. PMID 9263853 DOI: 10.1023/A:1007956612081 |
0.545 |
|
| 1997 |
He YA, He YQ, Szklarz GD, Halpert JR. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis. Biochemistry. 36: 8831-9. PMID 9220969 DOI: 10.1021/Bi970182I |
0.41 |
|
| 1997 |
Harlow GR, He YA, Halpert JR. Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11. Biochimica Et Biophysica Acta. 1338: 259-66. PMID 9128144 DOI: 10.1016/S0167-4838(96)00209-9 |
0.558 |
|
| 1997 |
Harlow GR, Halpert JR. Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. The Journal of Biological Chemistry. 272: 5396-402. PMID 9038138 DOI: 10.1074/Jbc.272.9.5396 |
0.51 |
|
| 1996 |
He YQ, Szklarz GD, Halpert JR. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues. Archives of Biochemistry and Biophysics. 335: 152-60. PMID 8914846 DOI: 10.1006/Abbi.1996.0493 |
0.55 |
|
| 1996 |
He K, He YA, Szklarz GD, Halpert JR, Correia MA. Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation. The Journal of Biological Chemistry. 271: 25864-72. PMID 8824218 DOI: 10.1074/Jbc.271.42.25864 |
0.562 |
|
| 1996 |
Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4. Archives of Biochemistry and Biophysics. 327: 308-18. PMID 8619620 DOI: 10.1006/Abbi.1996.0127 |
0.594 |
|
| 1996 |
Liu J, He YA, Halpert JR. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11. Archives of Biochemistry and Biophysics. 327: 167-73. PMID 8615687 DOI: 10.1006/Abbi.1996.0105 |
0.549 |
|
| 1996 |
Harlow GR, Halpert JR. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase. Archives of Biochemistry and Biophysics. 326: 85-92. PMID 8579377 DOI: 10.1006/Abbi.1996.0050 |
0.567 |
|
| 1995 |
Halpert JR. Structural basis of selective cytochrome P450 inhibition. Annual Review of Pharmacology and Toxicology. 35: 29-53. PMID 7598496 DOI: 10.1146/Annurev.Pa.35.040195.000333 |
0.484 |
|
| 1995 |
Szklarz GD, He YA, Halpert JR. Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1. Biochemistry. 34: 14312-22. PMID 7578035 DOI: 10.1021/Bi00044A008 |
0.562 |
|
| 1995 |
He YQ, He YA, Halpert JR. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies. Chemical Research in Toxicology. 8: 574-9. PMID 7548737 DOI: 10.1021/TX00046A011 |
0.458 |
|
| 1994 |
Szklarz GD, Ornstein RL, Halpert JR. Application of 3-Dimensional Homology Modeling of Cytochrome P450 2B1 for Interpretation of Site-Directed Mutagenesis Results. Journal of Biomolecular Structure & Dynamics. 12: 61-78. PMID 22671908 DOI: 10.1080/07391102.1994.10508088 |
0.443 |
|
| 1994 |
Poet TS, Brendel K, Halpert JR. Inactivation of cytochromes P450 2B protects against cocaine-mediated toxicity in rat liver slices. Toxicology and Applied Pharmacology. 126: 26-32. PMID 8184429 DOI: 10.1006/Taap.1994.1086 |
0.379 |
|
| 1994 |
Halpert JR, Guengerich FP, Bend JR, Correia MA. Selective inhibitors of cytochromes P450. Toxicology and Applied Pharmacology. 125: 163-75. PMID 8171425 DOI: 10.1006/Taap.1994.1061 |
0.472 |
|
| 1994 |
He Y, Luo Z, Klekotka PA, Burnett VL, Halpert JR. Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites. Biochemistry. 33: 4419-24. PMID 8155660 DOI: 10.1021/BI00180A040 |
0.389 |
|
| 1994 |
Luo Z, He YA, Halpert JR. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase. Archives of Biochemistry and Biophysics. 309: 52-7. PMID 8117113 DOI: 10.1006/Abbi.1994.1083 |
0.486 |
|
| 1994 |
John GH, Hasler JA, He Y, Halpert JR. Escherichia coli expression and characterization of cytochromes p450 2B11, 2B1, and 2B5 Archives of Biochemistry and Biophysics. 314: 367-375. PMID 7979377 DOI: 10.1006/Abbi.1994.1455 |
0.531 |
|
| 1994 |
Laethem RM, Halpert JR, Koop DR. Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. Biochimica Et Biophysica Acta. 1206: 42-8. PMID 7910485 DOI: 10.1016/0167-4838(94)90070-1 |
0.526 |
|
| 1993 |
Ryan R, Grimm SW, Kedzie KM, Halpert JR, Philpot RM. Cloning, sequencing, and functional studies of phenobarbital-inducible forms of cytochrome P450 2B and 4B expressed in rabbit kidney. Archives of Biochemistry and Biophysics. 304: 454-63. PMID 8346920 DOI: 10.1006/Abbi.1993.1375 |
0.511 |
|
| 1993 |
Kedzie KM, Grimm SW, Chen F, Halpert JR. Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11. Biochimica Et Biophysica Acta. 1164: 124-32. PMID 8329443 DOI: 10.1016/0167-4838(93)90238-M |
0.586 |
|
| 1992 |
He YA, Balfour CA, Kedzie KM, Halpert JR. Role of residue 478 as a determinant of the substrate specificity of cytochrome P450 2B1. Biochemistry. 31: 9220-6. PMID 1390709 DOI: 10.1021/BI00153A015 |
0.345 |
|
| 1991 |
Halpert JR, Stevens JC. Cytochrome P-450 as a target of biological reactive intermediates. Advances in Experimental Medicine and Biology. 283: 105-9. PMID 2068976 DOI: 10.1007/978-1-4684-5877-0_11 |
0.419 |
|
| 1991 |
Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR. cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily. Biochimica Et Biophysica Acta. 1088: 319-22. PMID 2001406 DOI: 10.1016/0167-4781(91)90072-T |
0.324 |
|
| 1991 |
Kedzie KM, Philpot RM, Halpert JR. Functional expression of mammalian cytochromes P450IIB in the yeast Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 291: 176-86. PMID 1929429 DOI: 10.1016/0003-9861(91)90121-X |
0.397 |
|
| 1990 |
Graves PE, Elhag GA, Ciaccio PJ, Bourque DP, Halpert JR. cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Archives of Biochemistry and Biophysics. 281: 106-15. PMID 2116765 DOI: 10.1016/0003-9861(90)90419-Y |
0.345 |
|
| 1989 |
Duignan DB, Sipes IG, Ciaccio PJ, Halpert JR. The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2. Archives of Biochemistry and Biophysics. 267: 294-304. PMID 3143308 DOI: 10.1016/0003-9861(88)90035-5 |
0.434 |
|
| 1989 |
Ciaccio PJ, Halpert JR. Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily. Archives of Biochemistry and Biophysics. 271: 284-99. PMID 2786372 DOI: 10.1016/0003-9861(89)90279-8 |
0.372 |
|
| 1989 |
Halpert JR, Jaw JY, Johnson EF. Design of specific mechanism-based inactivators of hepatic and adrenal microsomal cytochromes P-450 responsible for progesterone 21-hydroxylation. Drug Metabolism Reviews. 20: 645-55. PMID 2680401 DOI: 10.3109/03602538909103567 |
0.387 |
|
| 1988 |
Halpert J, Balfour C, Kaminsky LS. Effect of chloramphenicol administration in vivo on cytochrome P-450-dependent monooxygenase activities in liver microsomes from uninduced male rats. Biochemical Pharmacology. 37: 3046-8. PMID 3395379 DOI: 10.1016/0006-2952(88)90297-3 |
0.362 |
|
| 1988 |
Halpert J, Jaw JY, Balfour C, Mash EA, Johnson EF. Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation. Archives of Biochemistry and Biophysics. 264: 462-71. PMID 3261153 DOI: 10.1016/0003-9861(88)90311-6 |
0.492 |
|
| 1988 |
Halpert JR. Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes. Archives of Biochemistry and Biophysics. 263: 59-68. PMID 3130803 DOI: 10.1016/0003-9861(88)90613-3 |
0.461 |
|
| 1986 |
Toftgård R, Haaparanta T, Eng L, Halpert J. Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane. Biochemical Pharmacology. 35: 3733-8. PMID 3778502 DOI: 10.1016/0006-2952(86)90658-1 |
0.405 |
|
| 1986 |
Toftgård R, Haaparanta T, Halpert J. Rat lung and liver cytochrome P-450 isozymes involved in the hydroxylation of m-xylene. Toxicology. 39: 225-231. PMID 3705085 DOI: 10.1016/0300-483X(86)90024-7 |
0.416 |
|
| 1985 |
Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T, Mayer RT. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochemical Pharmacology. 34: 3337-3345. PMID 3929792 DOI: 10.1016/0006-2952(85)90355-7 |
0.409 |
|
| 1982 |
Neal RA, Halpert J. Toxicology of thiono-sulfur compounds. Annual Review of Pharmacology and Toxicology. 22: 321-39. PMID 7044288 DOI: 10.1146/Annurev.Pa.22.040182.001541 |
0.424 |
|
| Show low-probability matches. |