cached image

Brian J. Bacskai - Publications

Affiliations: 
Neurology Massachusetts General Hospital, Boston, MA 
Area:
Alzheimer's
Website:
http://dms.hms.harvard.edu/neuroscience/fac/Bacskai.php

172 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Scherlek AA, Kozberg MG, Nicoll JAR, Perosa V, Freeze WM, van der Weerd L, Bacskai BJ, Greenberg SM, Frosch MP, Boche D, van Veluw SJ. Histopathological correlates of haemorrhagic lesions on magnetic resonance imaging in immunized Alzheimer's disease cases. Brain Communications. 4: fcac021. PMID 35224489 DOI: 10.1093/braincomms/fcac021  0.344
2021 Perosa V, Oltmer J, Munting LP, Freeze WM, Auger CA, Scherlek AA, van der Kouwe AJ, Iglesias JE, Atzeni A, Bacskai BJ, Viswanathan A, Frosch MP, Greenberg SM, van Veluw SJ. Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex. Acta Neuropathologica. PMID 34928427 DOI: 10.1007/s00401-021-02393-1  0.31
2021 Garcia-Alloza M, Bacskai BJ, Calvo-Rodriguez M. Mitochondria-ER contacts and glucose: the powerhouse of Alzheimer's disease? Cell Calcium. 97: 102434. PMID 34186204 DOI: 10.1016/j.ceca.2021.102434  0.774
2021 Lee YF, Lariviere L, Russ AN, Choi SZ, Bacskai BJ, Kastanenka KV. Novel botanical therapeutic NB-02 effectively treats Alzheimer's neuropathophysiology in an APP/PS1 mouse model. Eneuro. PMID 33926907 DOI: 10.1523/ENEURO.0389-20.2021  0.821
2021 Calvo-Rodriguez M, Kharitonova EK, Bacskai BJ. In vivo brain imaging of mitochondrial Ca in neurodegenerative diseases with multiphoton microscopy. Biochimica Et Biophysica Acta. Molecular Cell Research. 1868: 118998. PMID 33684410 DOI: 10.1016/j.bbamcr.2021.118998  0.715
2020 Calvo-Rodriguez M, Kharitonova EK, Bacskai BJ. Therapeutic Strategies to Target Calcium Dysregulation in Alzheimer's Disease. Cells. 9. PMID 33233678 DOI: 10.3390/cells9112513  0.772
2020 Calvo-Rodriguez M, Bacskai BJ. Mitochondria and Calcium in Alzheimer's Disease: From Cell Signaling to Neuronal Cell Death. Trends in Neurosciences. PMID 33160650 DOI: 10.1016/j.tins.2020.10.004  0.767
2020 Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053  0.427
2020 Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Frontiers in Neuroscience. 14: 705. PMID 32714142 DOI: 10.3389/Fnins.2020.00705  0.81
2020 Calvo-Rodriguez M, Bacskai BJ. High mitochondrial calcium levels precede neuronal death in Alzheimer's disease. Cell Stress. 4: 187-190. PMID 32656500 DOI: 10.15698/cst2020.07.226  0.783
2020 Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S, Fan Z, Muzikansky A, Garcia-Alloza M, Serrano-Pozo A, Hudry E, Bacskai BJ. Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nature Communications. 11: 2146. PMID 32358564 DOI: 10.1038/S41467-020-16074-2  0.798
2020 van Veluw SJ, Frosch MP, Scherlek AA, Lee D, Greenberg SM, Bacskai BJ. In vivo characterization of spontaneous microhemorrhage formation in mice with cerebral amyloid angiopathy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19899377. PMID 31987010 DOI: 10.1177/0271678X19899377  0.424
2019 Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways. Nature Reviews. Neurology. PMID 31827267 DOI: 10.1038/S41582-019-0281-2  0.494
2019 van Veluw SJ, Hou SS, Calvo-Rodriguez M, Arbel-Ornath M, Snyder AC, Frosch MP, Greenberg SM, Bacskai BJ. Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain. Neuron. PMID 31810839 DOI: 10.1016/J.Neuron.2019.10.033  0.795
2019 Calvo-Rodriguez M, Hou SS, Snyder AC, Dujardin S, Shirani H, Nilsson KPR, Bacskai BJ. In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy. Acta Neuropathologica Communications. 7: 171. PMID 31703739 DOI: 10.1186/S40478-019-0832-1  0.796
2019 Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ. Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology. Scientific Reports. 9: 8964. PMID 31221985 DOI: 10.1038/S41598-019-44964-Z  0.815
2019 van Veluw SJ, Scherlek AA, Freeze WM, Ter Telgte A, van der Kouwe AJ, Bacskai BJ, Frosch MP, Greenberg SM. Different microvascular alterations underlie microbleeds and microinfarcts. Annals of Neurology. PMID 31152566 DOI: 10.1002/Ana.25512  0.4
2019 van Veluw SJ, Reijmer YD, van der Kouwe AJ, Charidimou A, Riley GA, Leemans A, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy. Neurology. PMID 30700595 DOI: 10.1212/Wnl.0000000000007005  0.334
2019 Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ. Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke. STROKEAHA118023788. PMID 30661497 DOI: 10.1161/Strokeaha.118.023788  0.339
2018 Ji M, Arbel M, Zhang L, Freudiger CW, Hou SS, Lin D, Yang X, Bacskai BJ, Xie XS. Label-free imaging of amyloid plaques in Alzheimer's disease with stimulated Raman scattering microscopy. Science Advances. 4: eaat7715. PMID 30456301 DOI: 10.1126/Sciadv.Aat7715  0.474
2018 Kelly P, Hudry E, Hou SS, Bacskai BJ. Two Photon Imaging of Astrocytic Structure and Function in Alzheimer's Disease. Frontiers in Aging Neuroscience. 10: 219. PMID 30072889 DOI: 10.3389/Fnagi.2018.00219  0.662
2018 Hierro-Bujalance C, Bacskai BJ, Garcia-Alloza M. Imaging of Microglia With Multiphoton Microscopy. Frontiers in Aging Neuroscience. 10: 218. PMID 30072888 DOI: 10.3389/Fnagi.2018.00218  0.8
2018 Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging. Scientific Reports. 8: 4634. PMID 29545579 DOI: 10.1038/S41598-018-22979-2  0.811
2018 Pagnier GJ, Kastanenka KV, Sohn M, Choi S, Choi SH, Soh H, Bacskai BJ. Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models. Alzheimer's Research & Therapy. 10: 11. PMID 29378621 DOI: 10.1186/S13195-018-0338-2  0.814
2017 Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain : a Journal of Neurology. PMID 28334869 DOI: 10.1093/Brain/Awx047  0.41
2017 Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Molecular Neurodegeneration. 12: 27. PMID 28327181 DOI: 10.1186/S13024-017-0169-9  0.821
2017 Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 6. PMID 28132667 DOI: 10.7554/Elife.19720  0.788
2017 Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. Plos One. 12: e0170275. PMID 28114405 DOI: 10.1371/Journal.Pone.0170275  0.807
2016 Kastanenka KV, Bussiere T, Shakerdge N, Qian F, Weinreb PH, Rhodes K, Bacskai BJ. Immunotherapy with aducanumab restores calcium homeostasis in Tg2576 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27810931 DOI: 10.1523/Jneurosci.2080-16.2016  0.8
2016 Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, Lechuga-Sancho AM, Bacskai BJ, Garcia-Alloza M. Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease. Molecular Neurobiology. PMID 27177549 DOI: 10.1007/S12035-016-9921-3  0.828
2016 Bakker EN, Bacskai BJ, Arbel-Ornath M, Aldea R, Bedussi B, Morris AW, Weller RO, Carare RO. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cellular and Molecular Neurobiology. PMID 26993512 DOI: 10.1007/S10571-015-0273-8  0.395
2016 Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Author response: Pathogenic PS1 phosphorylation at Ser367 Elife. DOI: 10.7554/Elife.19720.023  0.744
2016 Kastanenka K, Bussière T, Wang X, Hou S, Arbel M, Takeda S, Commins C, Qian F, Weinreb P, Rhodes K, Bacskai B. P1-033: Aducanumab Targets High Molecular Weight Soluble Aβ Oligomers and Restores Calcium to Normal Levels in TG2576 Mice Alzheimer's & Dementia. 12: P413-P414. DOI: 10.1016/J.Jalz.2016.06.780  0.785
2015 Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, Stanley HE, Hyman BT. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644572 DOI: 10.1073/Pnas.1516779112  0.555
2015 Zhao L, Arbel-Ornath M, Wang X, Betensky RA, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy. Neurobiology of Aging. PMID 26248866 DOI: 10.1016/J.Neurobiolaging.2015.07.016  0.476
2015 Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, ... ... Bacskai BJ, et al. Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. Annals of Neurology. 78: 193-210. PMID 26032020 DOI: 10.1002/Ana.24449  0.73
2015 Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, ... ... Bacskai BJ, et al. Abnormal synaptic Ca2+ homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice Annals of Neurology. 78: 193-210. DOI: 10.1002/ana.24449  0.717
2014 Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, et al. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathologica Communications. 2: 133. PMID 25200117 DOI: 10.1186/S40478-014-0133-7  0.505
2014 Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science (New York, N.Y.). 345: 1130. PMID 25190789 DOI: 10.1126/Science.1253146  0.711
2014 Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic (Copenhagen, Denmark). 15: 819-38. PMID 24891099 DOI: 10.1111/Tra.12178  0.43
2014 Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science (New York, N.Y.). 343: 670-5. PMID 24503855 DOI: 10.1126/Science.1245423  0.718
2014 Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 510-4. PMID 24368848 DOI: 10.1073/Pnas.1318807111  0.817
2014 Wang X, Arbel-Ornath M, Wegmann SK, Kastanenka KV, Bacskai BJ. In vivo imaging in neurodegenerative diseases Advances in Intravital Microscopy: From Basic to Clinical Research. 45-80. DOI: 10.1007/978-94-017-9361-2_3  0.744
2013 Garcia-Alloza M, Borrelli LA, Thyssen DH, Hickman SE, El Khoury J, Bacskai BJ. Four-dimensional microglia response to anti-Aβ treatment in APP/PS1xCX3CR1/GFP mice. Intravital. 2. PMID 28944103 DOI: 10.4161/intv.25693  0.707
2013 Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. Plos One. 8: e80834. PMID 24278327 DOI: 10.1371/Journal.Pone.0080834  0.568
2013 Xie H, Guan J, Borrelli LA, Xu J, Serrano-Pozo A, Bacskai BJ. Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17042-51. PMID 24155308 DOI: 10.1523/Jneurosci.1836-13.2013  0.486
2013 Arbel-Ornath M, Hudry E, Eikermann-Haerter K, Hou S, Gregory JL, Zhao L, Betensky RA, Frosch MP, Greenberg SM, Bacskai BJ. Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models. Acta Neuropathologica. 126: 353-64. PMID 23818064 DOI: 10.1007/S00401-013-1145-2  0.464
2013 Xie H, Hou S, Jiang J, Sekutowicz M, Kelly J, Bacskai BJ. Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 110: 7904-9. PMID 23610434 DOI: 10.1073/Pnas.1217938110  0.397
2013 Ramos-Rodriguez JJ, Pacheco-Herrero M, Thyssen D, Murillo-Carretero MI, Berrocoso E, Spires-Jones TL, Bacskai BJ, Garcia-Alloza M. Rapid β-amyloid deposition and cognitive impairment after cholinergic denervation in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 72: 272-85. PMID 23481704 DOI: 10.1097/Nen.0B013E318288A8Dd  0.816
2013 Kastanenka K, Bussiere T, Weinreb P, Qian F, Rhodes K, Bacskai B. P2-411: Amelioration of calcium dyshomeostasis by immunotherapy with BIIB037 in Tg2576 mice Alzheimer's & Dementia. 9: P508-P508. DOI: 10.1016/J.Jalz.2013.05.1061  0.758
2013 Kuchibhotla K, Wegmann S, Spires-Jones T, Bacskai B, Hyman B. O2-01-01: Neurofibrillary tangles remain functionally integrated in cortical networks Alzheimer's & Dementia. 9: P314-P314. DOI: 10.1016/J.Jalz.2013.04.135  0.724
2013 Hudry E, Arbel-Ornath M, Hashimoto T, Boivin J, Lattarulo C, Bacskai B, Hyman B. O1-01-03: Oligomeric soluble beta-amyloid species induce calcium dyshomeostasis in the healthy living mouse brain Alzheimer's & Dementia. 9: P126-P126. DOI: 10.1016/J.Jalz.2013.04.051  0.503
2012 Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/Jneurosci.1542-12.2012  0.563
2012 Gregory JL, Prada CM, Fine SJ, Garcia-Alloza M, Betensky RA, Arbel-Ornath M, Greenberg SM, Bacskai BJ, Frosch MP. Reducing available soluble β-amyloid prevents progression of cerebral amyloid angiopathy in transgenic mice. Journal of Neuropathology and Experimental Neurology. 71: 1009-17. PMID 23095848 DOI: 10.1097/Nen.0B013E3182729845  0.724
2012 Serrano-Pozo A, Mielke ML, Muzitansky A, Gómez-Isla T, Growdon JH, Bacskai BJ, Betensky RA, Frosch MP, Hyman BT. Stable size distribution of amyloid plaques over the course of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 71: 694-701. PMID 22805771 DOI: 10.1097/Nen.0B013E31825E77De  0.546
2012 Nabuurs RJ, Rutgers KS, Welling MM, Metaxas A, de Backer ME, Rotman M, Bacskai BJ, van Buchem MA, van der Maarel SM, van der Weerd L. In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a transgenic mouse model for Alzheimer's disease. Plos One. 7: e38284. PMID 22675537 DOI: 10.1371/Journal.Pone.0038284  0.347
2012 Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/Jneurosci.0227-12.2012  0.527
2012 Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/Jneurosci.6439-11.2012  0.582
2012 Lee JH, Bacskai BJ, Ayata C. Genetic animal models of cerebral vasculopathies. Progress in Molecular Biology and Translational Science. 105: 25-55. PMID 22137428 DOI: 10.1016/B978-0-12-394596-9.00002-0  0.348
2011 Garcia-Alloza M, Gregory J, Kuchibhotla KV, Fine S, Wei Y, Ayata C, Frosch MP, Greenberg SM, Bacskai BJ. Cerebrovascular lesions induce transient β-amyloid deposition. Brain : a Journal of Neurology. 134: 3697-707. PMID 22120142 DOI: 10.1093/Brain/Awr300  0.822
2011 Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/Journal.Pone.0014586  0.538
2011 Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (San Diego, Calif.). 53: 201-7. PMID 21163350 DOI: 10.1016/J.Ymeth.2010.12.009  0.594
2011 Rutgers KS, van Remoortere A, van Buchem MA, Verrips CT, Greenberg SM, Bacskai BJ, Frosch MP, van Duinen SG, Maat-Schieman ML, van der Maarel SM. Differential recognition of vascular and parenchymal beta amyloid deposition. Neurobiology of Aging. 32: 1774-83. PMID 20015576 DOI: 10.1016/J.Neurobiolaging.2009.11.012  0.36
2011 Hudry E, Hashimoto T, Scheel M, Dashkoff J, Spires-Jones T, Bacskai B, Davidson B, Hyman B. P2-465: Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 Alzheimer's & Dementia. 7: S461-S462. DOI: 10.1016/J.Jalz.2011.05.1337  0.544
2010 Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11745-61. PMID 20810895 DOI: 10.1523/Jneurosci.1769-10.2010  0.705
2010 de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 464: 1201-4. PMID 20357768 DOI: 10.1038/Nature08890  0.553
2010 Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/Jneurosci.4456-09.2010  0.816
2010 Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, et al. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 38: 482-91. PMID 20149872 DOI: 10.1016/J.Nbd.2010.01.019  0.744
2010 Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiology of Aging. 31: 2058-68. PMID 19124175 DOI: 10.1016/J.Neurobiolaging.2008.11.006  0.752
2010 Bacskai BJ, Kuchibhotla KV, Lattarulo C, Hyman BT. Dysregulation of Intracellular Calcium in Alzheimer's Disease Biophysical Journal. 98: 3a. DOI: 10.1016/J.Bpj.2009.12.015  0.799
2009 Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. Plos One. 4: e7893. PMID 19924286 DOI: 10.1371/Journal.Pone.0007893  0.53
2009 Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12636-40. PMID 19812338 DOI: 10.1523/Jneurosci.1948-09.2009  0.552
2009 Ran C, Xu X, Raymond SB, Ferrara BJ, Neal K, Bacskai BJ, Medarova Z, Moore A. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. Journal of the American Chemical Society. 131: 15257-61. PMID 19807070 DOI: 10.1021/Ja9047043  0.476
2009 Raymond SB, Kumar AT, Boas DA, Bacskai BJ. Optimal parameters for near infrared fluorescence imaging of amyloid plaques in Alzheimer's disease mouse models. Physics in Medicine and Biology. 54: 6201-16. PMID 19794239 DOI: 10.1088/0031-9155/54/20/011  0.419
2009 Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron. 63: 657-72. PMID 19755108 DOI: 10.1016/J.Neuron.2009.08.022  0.697
2009 Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. Journal of Neurochemistry. 111: 417-27. PMID 19686388 DOI: 10.1111/J.1471-4159.2009.06316.X  0.467
2009 Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli LA, Betensky R, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. Journal of Neurochemistry. 109: 1636-47. PMID 19457117 DOI: 10.1111/J.1471-4159.2009.06096.X  0.651
2009 Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular Neurodegeneration. 4: 19. PMID 19419556 DOI: 10.1186/1750-1326-4-19  0.764
2009 Atwood C, Bacskai B, Kuchibhotla K, Bezprozvanny I, Chakroborty S, Fagan T, Foskett K, Green K, Goussakov I, Moyer J, Michno K, Rybalchenko V, Stutzmann B, Villalobos C. Alzheimer research forum live discussion: Calcium in AD pathogenesis Journal of Alzheimer's Disease. 16: 909-917. PMID 19387122 DOI: 10.3233/Jad-2009-1026  0.762
2009 Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science (New York, N.Y.). 323: 1211-5. PMID 19251629 DOI: 10.1126/Science.1169096  0.812
2009 Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiology of Disease. 33: 213-20. PMID 19028582 DOI: 10.1016/J.Nbd.2008.10.011  0.581
2008 Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Erratum to Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. European Journal of Nuclear Medicine and Molecular Imaging. 35: 1032. PMID 28289876 DOI: 10.1007/S00259-008-0749-6  0.355
2008 Stoothoff WH, Bacskai BJ, Hyman BT. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. Journal of Biomedical Optics. 13: 064039. PMID 19123685 DOI: 10.1117/1.3050422  0.495
2008 Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14156-64. PMID 19109498 DOI: 10.1523/Jneurosci.4147-08.2008  0.748
2008 Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ. The nuclear membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 20434-9. PMID 19075240 DOI: 10.1073/Pnas.0808211106  0.388
2008 Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 59: 214-25. PMID 18667150 DOI: 10.1016/J.Neuron.2008.06.008  0.812
2008 Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, Bacskai BJ. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. Plos One. 3: e2175. PMID 18478109 DOI: 10.1371/Journal.Pone.0002175  0.479
2008 Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 451: 720-4. PMID 18256671 DOI: 10.1038/Nature06616  0.775
2008 Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. European Journal of Nuclear Medicine and Molecular Imaging. 35: S93-8. PMID 18236039 DOI: 10.1007/S00259-007-0708-7  0.386
2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/Jneurosci.3072-08.2008  0.495
2008 Prada CM, Garcia-Alloza M, Fine S, Betensky RA, Ebiana V, Greenber SM, Bacskai BJ, Frosch MP. P2-353: Reducing the availability of soluble Aβ halts progression of cerebral amyloid angiopathy in transgenic mice Alzheimer's & Dementia. 4: T476-T476. DOI: 10.1016/J.Jalz.2008.05.1431  0.716
2008 Raymond SB, Ferrara BG, Kumar AT, Boas DA, Bacskai BJ. P2-063: Near-infrared fluorescence imaging in transgenic mouse models of Alzheimer's disease Alzheimer's & Dementia. 4: T385-T385. DOI: 10.1016/J.Jalz.2008.05.1136  0.38
2008 Kuchibhotla KV, Goldman ST, Lattarulo CR, Hyman BT, Bacskai BJ. P1-473: Aβ disrupts spinodendritic calcium regulation in vivo Alzheimer's & Dementia. 4: T358-T358. DOI: 10.1016/J.Jalz.2008.05.1056  0.769
2008 Garcia-Alloza M, Prada C, Robbins EM, Betensky RA, Greenberg SM, Frosch MP, Bacskai BJ. P1-460: Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1043  0.665
2008 Raymond SB, Ferrara BG, Kumar AT, Boas DA, Bacskai BJ. IC-P1-047: Near-infrared fluorescence imaging in transgenic mouse models of Alzheimer's disease Alzheimer's & Dementia. 4: T27-T27. DOI: 10.1016/J.Jalz.2008.05.057  0.374
2007 Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiology of Disease. 28: 286-92. PMID 17822910 DOI: 10.1016/J.Nbd.2007.07.019  0.748
2007 Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. The American Journal of Pathology. 171: 1304-11. PMID 17717139 DOI: 10.2353/Ajpath.2007.070055  0.557
2007 Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain : a Journal of Neurology. 130: 2310-9. PMID 17638859 DOI: 10.1093/Brain/Awm156  0.733
2007 Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102: 1095-104. PMID 17472706 DOI: 10.1111/J.1471-4159.2007.04613.X  0.77
2007 Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Archives of Neurology. 64: 431-4. PMID 17353389 DOI: 10.1001/Archneur.64.3.431  0.542
2007 Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1973-80. PMID 17314293 DOI: 10.1523/Jneurosci.5426-06.2007  0.733
2007 Frosch MP, Prada CM, Betensky RA, Garcia-Alloza M, Greenberg SM, Bacskai BJ. Effect of passive immunotherapy on the rate of progression of cerebral amyloid angiopathy (caa) in transgenic mice: 126.7 Journal of Neuropathology and Experimental Neurology. 66: 434-435. DOI: 10.1097/01.Jnen.0000268872.45065.C2  0.691
2007 Frosch MP, Prada CM, Betensky RA, Garcia-Alloza M, Greenberg SM, Bacskai BJ. Effect of passive immunotherapy on the rate of progression of cerebral amyloid angiopathy (caa) in transgenic mice Journal of Neuropathology and Experimental Neurology. 66: 434-435. DOI: 10.1096/Fasebj.21.5.A73-D  0.691
2006 Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. Journal of Biomedical Optics. 11: 054024. PMID 17092173 DOI: 10.1117/1.2363367  0.454
2006 Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. Journal of Neuropathology and Experimental Neurology. 65: 1082-9. PMID 17086105 DOI: 10.1097/01.Jnen.0000240468.12543.Af  0.735
2006 Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of Disease. 24: 516-24. PMID 17029828 DOI: 10.1016/J.Nbd.2006.08.017  0.727
2006 Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. The Embo Journal. 25: 4163-74. PMID 16946707 DOI: 10.1038/Sj.Emboj.7601298  0.415
2006 Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Research. 1111: 222-6. PMID 16919608 DOI: 10.1016/J.Brainres.2006.06.041  0.397
2006 Skoch J, Hyman BT, Bacskai BJ. Preclinical characterization of amyloid imaging probes with multiphoton microscopy. Journal of Alzheimer's Disease : Jad. 9: 401-7. PMID 16914878 DOI: 10.3233/Jad-2006-9S345  0.541
2006 Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 365-71. PMID 16407531 DOI: 10.1523/Jneurosci.3854-05.2006  0.753
2006 Freeze WM, Greenberg SM, Frosch MP, Jacobs HI, Backes WH, Bacskai B, van Veluw SJ. IC-P-051: BLOOD-BRAIN BARRIER LEAKAGE AND MICROVASCULAR LESIONS IN CEREBRAL AMYLOID ANGIOPATHY: A POSTMORTEM MRI AND HISTOPATHOLOGY STUDY Alzheimer's & Dementia. 14: P50-P50. DOI: 10.1016/J.Jalz.2018.06.1172  0.308
2006 Meyer-Luehmann M, Spires TL, Bacskai BJ, Hyman BT. P1-090: Observation of new senile plaque formation and associated neuritic abnormalities using multiphoton microscopy Alzheimer's & Dementia. 2: S121-S121. DOI: 10.1016/J.Jalz.2006.05.465  0.48
2006 Garcia-Alloza M, Dodwell SA, Borrelli LA, Raju S, Bacskai BJ. P4-342: In vivo reduction of plaque size in APPswe/PS1d9 mice treated with curcumin Alzheimer's & Dementia. 2: S617-S617. DOI: 10.1016/J.Jalz.2006.05.2083  0.653
2006 Subramanian MP, Das P, Fauq A, Raju S, Irizarry MC, Golde TE, Bacskai BJ. P4-294: In vivo effects of a gamma secretase inhibitor on plaque size and dendritic curvature monitored longitudinally with multiphoton microscopy Alzheimer's & Dementia. 2: S603-S603. DOI: 10.1016/J.Jalz.2006.05.2033  0.305
2006 Prada C, Betensky R, Garcia-Alloza M, Zhang-Nunes S, Greenberg SM, Bacskai BJ, Frosch MP. P4-292: Effect of immunotherapy on the rate of progression of cerebral amyloid angiopathy (CAA) in transgenic mice Alzheimer's & Dementia. 2: S602-S603. DOI: 10.1016/J.Jalz.2006.05.2031  0.687
2006 Bacskai BJ, Raymond S, Kumar AT, Boas DA. IC-P-126: Non-invasive optical imaging of amyloid in APP-transgenic mice Alzheimer's & Dementia. 2: S702-S703. DOI: 10.1016/J.Jalz.2006.05.1225  0.368
2005 Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7278-87. PMID 16079410 DOI: 10.1523/Jneurosci.1879-05.2005  0.601
2005 Nesterov EE, Skoch J, Hyman BT, Klunk WE, Bacskai BJ, Swager TM. In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angewandte Chemie (International Ed. in English). 44: 5452-6. PMID 16059955 DOI: 10.1002/Anie.200500845  0.493
2005 Xiang Z, Nesterov EE, Skoch J, Lin T, Hyman BT, Swager TM, Bacskai BJ, Reeves SA. Detection of myelination using a novel histological probe. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1511-6. PMID 16046669 DOI: 10.1369/Jhc.5A6704.2005  0.403
2005 Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 64: 588-94. PMID 16042310 DOI: 10.1097/01.Jnen.0000171644.00180.Fc  0.76
2005 Skoch J, Hickey GA, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods in Molecular Biology (Clifton, N.J.). 299: 349-63. PMID 15980616 DOI: 10.1385/1-59259-874-9:349  0.572
2005 Golde TE, Bacskai BJ. Bringing amyloid into focus. Nature Biotechnology. 23: 552-4. PMID 15877070 DOI: 10.1038/Nbt0505-552  0.434
2005 Skoch J, Dunn A, Hyman BT, Bacskai BJ. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. Journal of Biomedical Optics. 10: 11007. PMID 15847573 DOI: 10.1117/1.1846075  0.545
2005 Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3009-17. PMID 15772361 DOI: 10.1523/Jneurosci.0364-05.2005  0.519
2005 von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, et al. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of Biological Chemistry. 280: 17777-85. PMID 15749709 DOI: 10.1074/Jbc.M414248200  0.507
2005 Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/Jci23269  0.617
2004 Garcia-Alloza M, Bacskai BJ. Techniques for brain imaging in vivo. Neuromolecular Medicine. 6: 65-78. PMID 15781977 DOI: 10.1385/Nmm:6:1:065  0.647
2004 Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nature Medicine. 10: 1065-6. PMID 15448688 DOI: 10.1038/Nm1112  0.49
2004 Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 43: 19-30. PMID 15233914 DOI: 10.1016/J.Neuron.2004.06.021  0.439
2004 Stern EA, Bacskai BJ, Hickey GA, Attenello FJ, Lombardo JA, Hyman BT. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4535-40. PMID 15140924 DOI: 10.1523/Jneurosci.0462-04.2004  0.58
2004 Mandal AK, Skoch J, Bacskai BJ, Hyman BT, Christmas P, Miller D, Yamin TT, Xu S, Wisniewski D, Evans JF, Soberman RJ. The membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 6587-92. PMID 15084748 DOI: 10.1073/Pnas.0308523101  0.415
2004 Bacskai BJ, Skoch J, Hickey GA, Berezovska O, Hyman BT. Multiphoton imaging in mouse models of Alzheimer's disease Proceedings of Spie - the International Society For Optical Engineering. 5323: 71-76. DOI: 10.1117/12.537940  0.554
2004 Levene MJ, Dombeck DA, Williams RM, Skoch J, Hickey GA, Kasischke KA, Molloy RP, Ingelsson M, Stern EA, Klucken J, Bacskai BJ, Zipfel WR, Hyman BT, Webb WW. In vivo multiphoton microscopy of deep tissue with gradient index lenses Proceedings of Spie - the International Society For Optical Engineering. 5323: 291-296. DOI: 10.1117/12.537285  0.507
2004 Robbins EM, Domnitz SB, Rebeck G, Greenberg SM, Frosch MP, Bacskai BJ. P2-076 Progression of cerebrovascular β-amyloid deposition in living mice Neurobiology of Aging. 25: S245. DOI: 10.1016/S0197-4580(04)80823-6  0.394
2004 Brendza RP, Bacskai BJ, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Holtzman DM. P2-063 In vivo dynamics of amyloid associated neuritic dystrophy before and after anti-Aβ immunotherapy Neurobiology of Aging. 25: S241-S242. DOI: 10.1016/S0197-4580(04)80810-8  0.405
2004 Bacskai BJ, Skoch J, Klunk WE, Nesterov E, Swager TM, Mathis CA, Dunn A, Hyman BT. O3-03-04 Novel approaches for non-invasive optical detection of amyloid-β plaques in vivo Neurobiology of Aging. 25: S57-S58. DOI: 10.1016/S0197-4580(04)80194-5  0.462
2003 Klunk WE, Engler H, Nordberg A, Bacskai BJ, Wang Y, Price JC, Bergström M, Hyman BT, LÃ¥ngström B, Mathis CA. Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. Neuroimaging Clinics of North America. 13: 781-9, ix. PMID 15024961 DOI: 10.1016/S1052-5149(03)00092-3  0.58
2003 Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10879-83. PMID 14645482  0.523
2003 Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. Journal of Neurochemistry. 87: 843-50. PMID 14622115 DOI: 10.1046/J.1471-4159.2003.02030.X  0.426
2003 Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 12462-7. PMID 14517353 DOI: 10.1073/Pnas.2034101100  0.607
2003 Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. The Journal of Biological Chemistry. 278: 50466-73. PMID 14506282 DOI: 10.1074/Jbc.M307247200  0.41
2003 Bacskai BJ, Skoch J, Hickey GA, Allen R, Hyman BT. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. Journal of Biomedical Optics. 8: 368-75. PMID 12880341 DOI: 10.1117/1.1584442  0.446
2003 Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Science of Aging Knowledge Environment : Sage Ke. 2003: PE14. PMID 12844526 DOI: 10.1126/Sageke.2003.23.Pe14  0.484
2003 Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4560-6. PMID 12805296  0.46
2003 McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2212-7. PMID 12657680 DOI: 10.1523/Jneurosci.23-06-02212.2003  0.585
2003 Greenberg SM, Bacskai BJ, Hyman BT. Alzheimer disease's double-edged vaccine. Nature Medicine. 9: 389-90. PMID 12640449 DOI: 10.1038/Nm847  0.496
2003 D'Amore JD, Kajdasz ST, McLellan ME, Bacskai BJ, Stern EA, Hyman BT. In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. Journal of Neuropathology and Experimental Neurology. 62: 137-45. PMID 12578223 DOI: 10.1093/Jnen/62.2.137  0.6
2003 Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-β Antibody Treatment Leads to Rapid Normalization of Plaque-Induced Neuritic Alterations The Journal of Neuroscience. 23: 10879-10883. DOI: 10.1523/Jneurosci.23-34-10879.2003  0.581
2003 Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging The Journal of Neuroscience. 23: 4560-4566. DOI: 10.1523/Jneurosci.23-11-04560.2003  0.523
2002 Bacskai BJ, Hyman BT. Alzheimer's disease: what multiphoton microscopy teaches us. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 386-90. PMID 12374422 DOI: 10.1177/107385802236963  0.55
2002 Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. Journal of Neuropathology and Experimental Neurology. 61: 797-805. PMID 12230326 DOI: 10.1093/Jnen/61.9.797  0.573
2002 Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7873-8. PMID 12223540  0.468
2002 Bacskai BJ, Klunk WE, Mathis CA, Hyman BT. Imaging amyloid-beta deposits in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 1035-41. PMID 12218409 DOI: 10.1097/00004647-200209000-00001  0.558
2002 Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6331-5. PMID 12151510  0.493
2002 Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang GF, Debnath ML, Klunk WE. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorganic & Medicinal Chemistry Letters. 12: 295-8. PMID 11814781 DOI: 10.1016/S0960-894X(01)00734-X  0.555
2002 Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT. Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-β In Vivo by Immunotherapy The Journal of Neuroscience. 22: 7873-7878. DOI: 10.1523/Jneurosci.22-18-07873.2002  0.532
2002 Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH. Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease The Journal of Neuroscience. 22: 6331-6335. DOI: 10.1523/Jneurosci.22-15-06331.2002  0.557
2001 Kimchi EY, Kajdasz S, Bacskai BJ, Hyman BT. Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy. Journal of Neuropathology and Experimental Neurology. 60: 274-9. PMID 11245211 DOI: 10.1093/Jnen/60.3.274  0.595
2001 Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nature Medicine. 7: 369-72. PMID 11231639 DOI: 10.1038/85525  0.567
2001 Christie RH, Bacskai BJ, Zipfel WR, Williams RM, Kajdasz ST, Webb WW, Hyman BT. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 858-64. PMID 11157072 DOI: 10.1523/Jneurosci.21-03-00858.2001  0.56
2001 Bacskai BJ, Kajdasz ST, Christie RH, Zipfel WR, Williams RM, Kasischke KA, Webb WW, Hyman BT. Chronic imaging of amyloid plaques in the live mouse brain using multiphoton microscopy Proceedings of Spie - the International Society For Optical Engineering. 4262: 125-133. DOI: 10.1117/12.424546  0.465
2000 Bacskai BJ, Xia MQ, Strickland DK, Rebeck GW, Hyman BT. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 11551-6. PMID 11016955 DOI: 10.1073/Pnas.200238297  0.437
2000 Xia MQ, Bacskai BJ, Knowles RB, Qin SX, Hyman BT. Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. Journal of Neuroimmunology. 108: 227-35. PMID 10900358 DOI: 10.1016/S0165-5728(00)00285-X  0.553
2000 Bacskai BJ, Kajdasz S, Carter C, Christie R, Schenk D, Games D, Seubert P, Hyman BT. In vivo imaging of amyloid deposits in transgenic models of Alzheimer's disease using multi-photon microscopy Neurobiology of Aging. 21: 130. DOI: 10.1016/S0197-4580(00)82385-4  0.583
1995 Bacskai BJ, Wallén P, Lev-Ram V, Grillner S, Tsien RY. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron. 14: 19-28. PMID 7826636 DOI: 10.1016/0896-6273(95)90237-6  0.494
1994 Ranganathan R, Bacskai BJ, Tsien RY, Zuker CS. Cytosolic calcium transients: spatial localization and role in Drosophila photoreceptor cell function. Neuron. 13: 837-48. PMID 7946332 DOI: 10.1016/0896-6273(94)90250-X  0.483
1994 Civitelli R, Bacskai BJ, Mahaut-Smith MP, Adams SR, Avioli LV, Tsien RY. Single-cell analysis of cyclic AMP response to parathyroid hormone in osteoblastic cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 9: 1407-17. PMID 7817824 DOI: 10.1002/Jbmr.5650090912  0.476
1993 Tsien RY, Bacskai BJ, Adams SR. FRET for studying intracellular signalling. Trends in Cell Biology. 3: 242-5. PMID 14731760 DOI: 10.1016/0962-8924(93)90124-J  0.45
1993 Adams SR, Bacskai BJ, Hochner B, Kaang BK, Kandel ER, Mahaut-Smith M, Tsien RY. Confocal imaging of cAMP signals in Aplysia neurons. The Japanese Journal of Physiology. 43: S91-3. PMID 8271521  0.442
1993 Bacskai BJ, Hochner B, Mahaut-Smith M, Adams SR, Kaang BK, Kandel ER, Tsien RY. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (New York, N.Y.). 260: 222-6. PMID 7682336 DOI: 10.1126/Science.7682336  0.49
1991 Pizzonia JH, Gesek FA, Kennedy SM, Coutermarsh BA, Bacskai BJ, Friedman PA. Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney. In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association. 27: 409-16. PMID 1649164 DOI: 10.1007/Bf02630961  0.463
1990 Bacskai BJ, Friedman PA. Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone. Nature. 347: 388-91. PMID 1699128 DOI: 10.1038/347388A0  0.478
Show low-probability matches.