Tian-Le Xu, Ph.D. - Publications

Shanghai Jiao Tong University School of Medicine 
ASICs, Inhibitory transmission

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sun PY, Li HG, Xu QY, Zhang Z, Chen JW, Shen YH, Qi X, Lu JF, Tan YD, Wang XX, Li CX, Yang MY, Ma YZ, Lu Y, Xu TL, et al. Lidocaine alleviates inflammation and pruritus in atopic dermatitis by blocking different population of sensory neurons. British Journal of Pharmacology. PMID 36521846 DOI: 10.1111/bph.16012  0.529
2022 Wang Q, Zhu JJ, Wang L, Kan YP, Liu YM, Wu YJ, Gu X, Yi X, Lin ZJ, Wang Q, Lu JF, Jiang Q, Li Y, Liu MG, Xu NJ, ... ... Xu TL, et al. Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways. Nature Communications. 13: 5540. PMID 36130959 DOI: 10.1038/s41467-022-33241-9  0.532
2022 Gu X, Wu YJ, Zhang Z, Zhu JJ, Wu XR, Wang Q, Yi X, Lin ZJ, Jiao ZH, Xu M, Jiang Q, Li Y, Xu NJ, Zhu MX, Wang LY, ... ... Xu TL, et al. Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory. Molecular Psychiatry. PMID 35804093 DOI: 10.1038/s41380-022-01684-7  0.537
2021 Li WG, Wu YJ, Gu X, Fan HR, Wang Q, Zhu JJ, Yi X, Wang Q, Jiang Q, Li Y, Yuan TF, Xu H, Lu J, Xu NJ, Zhu MX, ... Xu TL, et al. Input associativity underlies fear memory renewal. National Science Review. 8: nwab004. PMID 34691732 DOI: 10.1093/nsr/nwab004  0.542
2021 Zhang X, Liu Y, Hong X, Li X, Meshul CK, Moore C, Yang Y, Han Y, Li WG, Qi X, Lou H, Duan S, Xu TL, Tong X. NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety. Nature Communications. 12: 5740. PMID 34593806 DOI: 10.1038/s41467-021-25956-y  0.581
2020 Yuan TF, Li WG, Zhang C, Wei H, Sun S, Xu NJ, Liu J, Xu TL. Targeting neuroplasticity in patients with neurodegenerative diseases using brain stimulation techniques. Translational Neurodegeneration. 9: 44. PMID 33280613 DOI: 10.1186/s40035-020-00224-z  0.485
2020 Wang YJ, Liu MG, Wang JH, Cao W, Wu C, Wang ZY, Liu L, Yang F, Feng ZH, Sun L, Zhang F, Shen Y, Zhou YD, Zhuo M, Luo JH, ... Xu TL, et al. Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity. Cell Reports. 33: 108369. PMID 33176141 DOI: 10.1016/j.celrep.2020.108369  0.401
2020 Song XL, Liu DS, Qiang M, Li Q, Liu MG, Li WG, Qi X, Xu NJ, Yang G, Zhu MX, Xu TL. Postsynaptic Targeting and Mobility of Membrane Surface-Localized hASIC1a. Neuroscience Bulletin. PMID 32996060 DOI: 10.1007/s12264-020-00581-9  0.673
2020 Ma R, Ma L, Weng W, Wang Y, Liu H, Guo R, Gao Y, Tu J, Xu TL, Cheng J, Zhu MX, Zhou A, Li Y. DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation. Science Advances. 6: eaaz0361. PMID 32232156 DOI: 10.1126/Sciadv.Aaz0361  0.334
2020 Lai K, Song XL, Shi HS, Qi X, Li CY, Fang J, Wang F, Maximyuk O, Krishtal O, Xu TL, Li XY, Ni K, Li WP, Shi HB, Wang LY, et al. Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice. Science Translational Medicine. 12. PMID 32051225 DOI: 10.1126/Scitranslmed.Aax1337  0.386
2020 Wang JJ, Liu F, Yang F, Wang YZ, Qi X, Li Y, Hu Q, Zhu MX, Xu TL. Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis. Nature Communications. 11: 475. PMID 31980622 DOI: 10.1038/S41467-019-13873-0  0.597
2019 Li HS, Su XY, Song XL, Qi X, Li Y, Wang RQ, Maximyuk O, Krishtal O, Wang T, Fang H, Liao L, Cao H, Zhang YQ, Zhu MX, Liu MG, ... Xu TL, et al. Protein kinase C lambda mediates acid-sensing ion channel 1a-dependent cortical synaptic plasticity and pain hypersensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31101759 DOI: 10.1523/Jneurosci.0213-19.2019  0.78
2019 Su XY, Chen M, Yuan Y, Li Y, Guo SS, Luo HQ, Huang C, Sun W, Li Y, Zhu MX, Liu MG, Hu J, Xu TL. Central Processing of Itch in the Midbrain Reward Center. Neuron. PMID 31000426 DOI: 10.1016/J.Neuron.2019.03.030  0.792
2018 Wang H, Li WG, Zeng K, Wu YJ, Zhang Y, Xu TL, Chen Y. Photocatalysis Enables Visible Light Uncaging of Bioactive Molecules in Live Cells. Angewandte Chemie (International Ed. in English). PMID 30418695 DOI: 10.1002/anie.201811261  0.487
2018 Wang Q, Wang Q, Song XL, Jiang Q, Wu YJ, Li Y, Yuan TF, Zhang S, Xu NJ, Zhu MX, Li WG, Xu TL. Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates. Science Advances. 4: eaau3075. PMID 30417090 DOI: 10.1126/Sciadv.Aau3075  0.565
2018 Liu DS, Xu TL. Cell-Type Identification in the Autonomic Nervous System. Neuroscience Bulletin. PMID 30171526 DOI: 10.1007/s12264-018-0284-9  0.479
2018 Yu Z, Wu YJ, Wang YZ, Liu DS, Song XL, Jiang Q, Li Y, Zhang S, Xu NJ, Zhu MX, Li WG, Xu TL. The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning. Science Signaling. 11. PMID 30087178 DOI: 10.1126/Scisignal.Aar4481  0.746
2018 Fan HR, Du WF, Zhu T, Wu YJ, Liu YM, Wang Q, Wang Q, Gu X, Shan X, Deng S, Zhu T, Xu TL, Ge WH, Li WG, Li F. Quercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity. Ebiomedicine. PMID 30057312 DOI: 10.1016/j.ebiom.2018.07.031  0.604
2018 Qiang M, Dong X, Zha Z, Zuo XK, Song XL, Zhao L, Yuan C, Huang C, Tao P, Hu Q, Li WG, Hu W, Li J, Nie Y, Buratto D, ... ... Xu TL, et al. Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death. Proceedings of the National Academy of Sciences of the United States of America. PMID 30042215 DOI: 10.1073/Pnas.1807233115  0.599
2018 Li Y, Zhu T, Yang H, Dib-Hajj S, Waxman S, Yu Y, Xu TL, Cheng X. [EXPRESS] Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner. Molecular Pain. 1744806918782229. PMID 29790812 DOI: 10.1177/1744806918782229  0.511
2018 Yan XG, Li WG, Qi X, Zhu JJ, Huang C, Han SL, Jiang Q, Xu TL, Liu JH. Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoid. Cns Neuroscience & Therapeutics. PMID 29781252 DOI: 10.1111/cns.12979  0.582
2018 Wang Y, Gao Y, Tian Q, Deng Q, Wang Y, Zhou T, Liu Q, Mei K, Wang Y, Liu H, Ma R, Ding Y, Rong W, Cheng J, Yao J, ... Xu TL, et al. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nature Communications. 9: 1529. PMID 29670121 DOI: 10.1038/S41467-018-03974-7  0.347
2017 Yang XN, Niu YY, Liu Y, Yang Y, Jin W, Cheng XY, Liang H, Wang HS, Hu YM, Lu XY, Zhu MX, Xu TL, Tian Y, Yu Y. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of native FMRFamide peptide. The Journal of Biological Chemistry. PMID 29123030 DOI: 10.1074/Jbc.M117.814707  0.516
2017 Jiang YM, Huang C, Peng Z, Han SL, Li WG, Zhu MX, Xu TL. Acidosis counteracts itch tachyphylaxis to consecutive pruritogen exposure dependent on acid-sensing ion channel 3. Molecular Pain. 13: 1744806917721114. PMID 28745101 DOI: 10.1177/1744806917721114  0.586
2017 Liu YM, Fan HR, Ding J, Huang C, Deng S, Zhu T, Xu TL, Ge WH, Li WG, Li F. Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines. Scientific Reports. 7: 46654. PMID 28436443 DOI: 10.1038/srep46654  0.603
2016 Li WG, Liu MG, Deng S, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F, Zhu MX, Xu TL. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nature Communications. 7: 13770. PMID 27924869 DOI: 10.1038/Ncomms13770  0.557
2016 Saur T, Peng IF, Jiang P, Gong N, Yao WD, Xu TL, Wu CF. K(+) channel reorganization and homeostatic plasticity during postembryonic development: biophysical and genetic analyses in acutely dissociated Drosophila central neurons. Journal of Neurogenetics. 1-17. PMID 27868467 DOI: 10.1080/01677063.2016.1255212  0.756
2016 Wang JJ, Xu TL. [Acid-sensing ion channels as a target for neuroprotection: acidotoxicity revisited]. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 68: 403-13. PMID 27546501  0.333
2016 Liu MG, Li HS, Li WG, Wu YJ, Deng SN, Huang C, Maximyuk O, Sukach V, Krishtal O, Zhu MX, Xu TL. Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms. Scientific Reports. 6: 23350. PMID 26996240 DOI: 10.1038/Srep23350  0.588
2016 Wang YZ, Wang JJ, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL. Correction: Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. Elife. 5. PMID 26799507 DOI: 10.7554/eLife.14128  0.553
2016 Luan Y, Chai D, Peng J, Ma S, Wang M, Ma H, Li X, Fu S, Pan X, Wang X, Qin S, Xu T. A fully human monoclonal antibody targeting PD-L1 with potent anti-tumor activity. International Immunopharmacology. 31: 248-256. PMID 26773772 DOI: 10.1016/j.intimp.2015.12.039  0.37
2016 Cheng C, Wang X, Xu T, Zhu Q, Sun L, Liao F, Pan Z, Liu S, Dai S, Shen X. Optical characteristics of novel Ge-Ga-Te-CsCl far-infrared chalcogenide glasses Kuei Suan Jen Hsueh Pao/Journal of the Chinese Ceramic Society. 44: 136-141. DOI: 10.14062/j.issn.0454-5648.2016.01.21  0.3
2016 Xu T, Zhao CZ, Duan BB, Han L, Zheng HL, Feng W. Slope-related variations of different levels of vein density and leaf size in Robinia pseudoacacia in the northern mountains of Lanzhou Chinese Journal of Ecology. 35: 41-47. DOI: 10.13292/j.1000-4890.201601.006  0.456
2016 He Y, Wu L, Pan J, Zhu Y, Ge X, Yang Z, Ran J, Xu T. A mechanically robust anion exchange membrane with high hydroxide conductivity Journal of Membrane Science. 504: 47-54. DOI: 10.1016/j.memsci.2016.01.008  0.407
2015 Wang YZ, Wang JJ, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL. Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. Elife. 4. PMID 26523449 DOI: 10.7554/Elife.05682  0.581
2015 Shang L, Xu TL, Li F, Su J, Li WG. Erratum to: Temporal dynamics of anxiety phenotypes in a dental pulp injury model. Molecular Pain. 11: 62. PMID 26446076 DOI: 10.1186/s12990-015-0064-8  0.461
2015 Peng Z, Li WG, Huang C, Jiang YM, Wang X, Zhu MX, Cheng X, Xu TL. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports. PMID 26440887 DOI: 10.1016/J.Celrep.2015.09.002  0.589
2015 Zeng WZ, Liu DS, Liu L, She L, Wu LJ, Xu TL. Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling. Scientific Reports. 5: 14125. PMID 26370138 DOI: 10.1038/srep14125  0.656
2015 Shang L, Xu TL, Li F, Su J, Li WG. Temporal dynamics of anxiety phenotypes in a dental pulp injury model. Molecular Pain. 11: 40. PMID 26122003 DOI: 10.1186/s12990-015-0040-3  0.54
2015 Tang D, Qian AH, Song DD, Ben QW, Yao WY, Sun J, Li WG, Xu TL, Yuan YZ. Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G767-78. PMID 25792562 DOI: 10.1152/ajpgi.00313.2014  0.553
2015 Li WG, Xu TL. Acid-sensing ion channels: a novel therapeutic target for pain and anxiety. Current Pharmaceutical Design. 21: 885-94. PMID 25345607  0.555
2014 Zeng WZ, Liu DS, Xu TL. Acid-sensing ion channels: trafficking and pathophysiology. Channels (Austin, Tex.). 8: 481-7. PMID 25483283 DOI: 10.4161/19336950.2014.958382  0.492
2014 Sun H, Lu L, Zuo Y, Wang Y, Jiao Y, Zeng WZ, Huang C, Zhu MX, Zamponi GW, Zhou T, Xu TL, Cheng J, Li Y. Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nature Communications. 5: 4980. PMID 25236484 DOI: 10.1038/Ncomms5980  0.344
2014 Zhao L, Gong N, Liu M, Pan X, Sang S, Sun X, Yu Z, Fang Q, Zhao N, Fei G, Jin L, Zhong C, Xu T. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model. Neurobiology of Aging. 35: 2736-45. PMID 25018109 DOI: 10.1016/J.Neurobiolaging.2014.06.003  0.695
2014 Ding J, Huang C, Peng Z, Xie Y, Deng S, Nie YZ, Xu TL, Ge WH, Li WG, Li F. Electrophysiological characterization of methyleugenol: a novel agonist of GABA(A) receptors. Acs Chemical Neuroscience. 5: 803-11. PMID 24980777 DOI: 10.1021/cn500022e  0.638
2014 Cao Q, Zhao K, Zhong XZ, Zou Y, Yu H, Huang P, Xu TL, Dong XP. SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. The Journal of Biological Chemistry. 289: 23189-99. PMID 24962569 DOI: 10.1074/Jbc.M114.567107  0.638
2014 Ding J, Wang JJ, Huang C, Wang L, Deng S, Xu TL, Ge WH, Li WG, Li F. Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors. Neuropharmacology. 81: 244-55. PMID 24565642 DOI: 10.1016/j.neuropharm.2014.02.009  0.587
2013 Yu Z, Fang Q, Xiao X, Wang YZ, Cai YQ, Cao H, Hu G, Chen Z, Fei J, Gong N, Xu TL. GABA transporter-1 deficiency confers schizophrenia-like behavioral phenotypes. Plos One. 8: e69883. PMID 23922840 DOI: 10.1371/Journal.Pone.0069883  0.748
2013 Xiao X, Zhu MX, Xu TL. 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors. Neuropharmacology. 75: 126-37. PMID 23916476 DOI: 10.1016/J.Neuropharm.2013.07.018  0.382
2013 Wang YZ, Zeng WZ, Xiao X, Huang Y, Song XL, Yu Z, Tang D, Dong XP, Zhu MX, Xu TL. Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell Death and Differentiation. 20: 1359-69. PMID 23852371 DOI: 10.1038/Cdd.2013.90  0.54
2013 Zeng WZ, Liu DS, Duan B, Song XL, Wang X, Wei D, Jiang W, Zhu MX, Li Y, Xu TL. Molecular mechanism of constitutive endocytosis of Acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7066-78. PMID 23595764 DOI: 10.1523/Jneurosci.5206-12.2013  0.721
2013 Wang X, Li WG, Yu Y, Xiao X, Cheng J, Zeng WZ, Peng Z, Xi Zhu M, Xu TL. Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4265-79. PMID 23467344 DOI: 10.1523/Jneurosci.3376-12.2013  0.663
2013 Huang C, Li WG, Zhang XB, Wang L, Xu TL, Wu D, Li Y. α-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors. Neuropharmacology. 65: 1-11. PMID 22975146 DOI: 10.1016/J.Neuropharm.2012.09.001  0.721
2012 Wang L, Li WG, Huang C, Zhu MX, Xu TL, Wu DZ, Li Y. Subunit-specific inhibition of glycine receptors by curcumol. The Journal of Pharmacology and Experimental Therapeutics. 343: 371-9. PMID 22892339 DOI: 10.1124/Jpet.112.195669  0.639
2012 Li WG, Xu TL. Emerging approaches to probing ion channel structure and function. Neuroscience Bulletin. 28: 351-74. PMID 22833035 DOI: 10.1007/s12264-012-1248-0  0.552
2012 Yang H, Gao Z, Li P, Yu K, Yu Y, Xu TL, Li M, Jiang H. A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel. Biophysical Journal. 102: 1815-25. PMID 22768937 DOI: 10.1016/J.Bpj.2012.03.032  0.482
2012 Duan B, Liu DS, Huang Y, Zeng WZ, Wang X, Yu H, Zhu MX, Chen ZY, Xu TL. PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6351-63. PMID 22553040 DOI: 10.1523/Jneurosci.4479-11.2012  0.692
2012 Yang Y, Yu Y, Cheng J, Liu Y, Liu DS, Wang J, Zhu MX, Wang R, Xu TL. Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels. The Journal of Biological Chemistry. 287: 14443-55. PMID 22399291 DOI: 10.1074/Jbc.M111.334250  0.622
2012 Shi J, Cai Y, Liu G, Gong N, Liu Z, Xu T, Wang Z, Fei J. Enhanced learning and memory in GAT1 heterozygous mice. Acta Biochimica Et Biophysica Sinica. 44: 359-66. PMID 22318715 DOI: 10.1093/Abbs/Gms005  0.705
2012 Zhao L, Gong N, Sun X, Yu Z, Fang Q, Zhao N, Pan X, Xu T, Zhong C. Beneficial effects of tri-lithium pyrroloquinoline quinonein on behaviors and pathology in a mouse model of Alzheimer’s disease Molecular Neurodegeneration. 7: O14. DOI: 10.1186/1750-1326-7-S1-O14  0.698
2011 Li WG, Xu TL. ASIC3 channels in multimodal sensory perception. Acs Chemical Neuroscience. 2: 26-37. PMID 22778854 DOI: 10.1021/cn100094b  0.594
2011 Li WG, Yu Y, Huang C, Cao H, Xu TL. Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride. The Journal of Biological Chemistry. 286: 42635-46. PMID 21998313 DOI: 10.1074/Jbc.M111.289058  0.67
2011 Wang YZ, Xu TL. Acidosis, acid-sensing ion channels, and neuronal cell death. Molecular Neurobiology. 44: 350-8. PMID 21932071 DOI: 10.1007/s12035-011-8204-2  0.588
2011 Yu Y, Li WG, Chen Z, Cao H, Yang H, Jiang H, Xu TL. Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels. The Journal of Biological Chemistry. 286: 24996-5006. PMID 21586569 DOI: 10.1074/Jbc.M111.239558  0.655
2011 Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2101-12. PMID 21307247 DOI: 10.1523/Jneurosci.4351-10.2011  0.757
2011 Wang D, Lü H, Xu T. Mediation by calcium/calmodulin-dependent protein kinase II of suppression of GABA(A) receptors by NMDA. Science in China. Series C, Life Sciences. 43: 655-62. PMID 18726361 DOI: 10.1007/BF02882287  0.308
2010 Li WG, Yu Y, Zhang ZD, Cao H, Xu TL. ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Molecular Pain. 6: 88. PMID 21143836 DOI: 10.1186/1744-8069-6-88  0.697
2010 Yu Y, Chen Z, Li WG, Cao H, Feng EG, Yu F, Liu H, Jiang H, Xu TL. A nonproton ligand sensor in the acid-sensing ion channel. Neuron. 68: 61-72. PMID 20920791 DOI: 10.1016/J.Neuron.2010.09.001  0.662
2010 Xu TL, Gong N. Glycine and glycine receptor signaling in hippocampal neurons: diversity, function and regulation. Progress in Neurobiology. 91: 349-61. PMID 20438799 DOI: 10.1016/j.pneurobio.2010.04.008  0.75
2010 Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, Sun X, Zhao L, Yu M, Xu Z, Dong W, Qin Y, Fei G, Zhong C, Xu TL. Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain : a Journal of Neurology. 133: 1342-51. PMID 20385653 DOI: 10.1093/Brain/Awq069  0.69
2009 Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL. GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15836-45. PMID 20016099 DOI: 10.1523/Jneurosci.4643-09.2009  0.732
2009 Yang H, Yu Y, Li WG, Xu TL, Jiang H. Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation. Cell Research. 19: 1035-7. PMID 19636341 DOI: 10.1038/Cr.2009.90  0.633
2009 Yang H, Yu Y, Li WG, Yu F, Cao H, Xu TL, Jiang H. Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. Plos Biology. 7: e1000151. PMID 19597538 DOI: 10.1371/Journal.Pbio.1000151  0.65
2009 Lu YG, Tang ZQ, Ye ZY, Wang HT, Huang YN, Zhou KQ, Zhang M, Xu TL, Chen L. Salicylate, an aspirin metabolite, specifically inhibits the current mediated by glycine receptors containing alpha1-subunits. British Journal of Pharmacology. 157: 1514-22. PMID 19594751 DOI: 10.1111/j.1476-5381.2009.00321.x  0.436
2009 Xu TL, Duan B. Calcium-permeable acid-sensing ion channel in nociceptive plasticity: a new target for pain control. Progress in Neurobiology. 87: 171-80. PMID 19388206 DOI: 10.1016/j.pneurobio.2009.01.004  0.595
2009 Jiang P, Kong Y, Zhang XB, Wang W, Liu CF, Xu TL. Glycine receptor in rat hippocampal and spinal cord neurons as a molecular target for rapid actions of 17-beta-estradiol. Molecular Pain. 5: 2. PMID 19138413 DOI: 10.1186/1744-8069-5-2  0.586
2008 Zhang XB, Jiang P, Gong N, Hu XL, Fei D, Xiong ZQ, Xu L, Xu TL. A-type GABA receptor as a central target of TRPM8 agonist menthol. Plos One. 3: e3386. PMID 18852885 DOI: 10.1371/Journal.Pone.0003386  0.802
2008 Ye ZY, Lu YG, Sun H, Cheng XP, Xu TL, Zhou JN. Fluoxetine inhibition of glycine receptor activity in rat hippocampal neurons. Brain Research. 1239: 77-84. PMID 18786514 DOI: 10.1016/j.brainres.2008.08.055  0.653
2008 Ye ZY, Zhou KQ, Xu TL, Zhou JN. Fluoxetine potentiates GABAergic IPSCs in rat hippocampal neurons. Neuroscience Letters. 442: 24-9. PMID 18606211 DOI: 10.1016/J.Neulet.2008.06.072  0.654
2008 Yang CX, Zhang XB, Gong N, Wang MY, Xu TL. Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors. Neurochemical Research. 33: 2159-65. PMID 18584323 DOI: 10.1007/S11064-008-9762-1  0.768
2008 Zhang M, Gong N, Lu YG, Jia NL, Xu TL, Chen L. Functional characterization of acid-sensing ion channels in cultured neurons of rat inferior colliculus. Neuroscience. 154: 461-72. PMID 18456416 DOI: 10.1016/J.Neuroscience.2008.03.040  0.747
2008 Zhang Z, Gong N, Wang W, Xu L, Xu TL. Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval. Cerebral Cortex (New York, N.Y. : 1991). 18: 2391-401. PMID 18281302 DOI: 10.1093/Cercor/Bhn008  0.725
2008 Zhang W, Liu LY, Xu TL. Reduced potassium-chloride co-transporter expression in spinal cord dorsal horn neurons contributes to inflammatory pain hypersensitivity in rats. Neuroscience. 152: 502-10. PMID 18262726 DOI: 10.1016/J.Neuroscience.2007.12.037  0.307
2008 Zhang XB, Sun GC, Liu LY, Yu F, Xu TL. Alpha2 subunit specificity of cyclothiazide inhibition on glycine receptors. Molecular Pharmacology. 73: 1195-202. PMID 18162605 DOI: 10.1124/Mol.107.042655  0.5
2008 Gong N, Zhang M, Zhang XB, Chen L, Sun GC, Xu TL. The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition. Neuropharmacology. 54: 454-63. PMID 18078964 DOI: 10.1016/J.Neuropharm.2007.10.017  0.796
2008 Zhao N, Zhong C, Wang Y, Zhao Y, Gong N, Zhou G, Xu T, Hong Z. Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage. Neurobiology of Disease. 29: 176-85. PMID 17936635 DOI: 10.1016/J.Nbd.2007.08.014  0.708
2008 Zhang LH, Gong N, Fei D, Xu L, Xu TL. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 701-11. PMID 17522628 DOI: 10.1038/Sj.Npp.1301449  0.741
2007 Shen B, Zhou K, Yang S, Xu T, Wang Y. The Kv4.2 mediates excitatory activity-dependent regulation of neuronal excitability in rat cortical neurons. Journal of Neurochemistry. 105: 773-83. PMID 18088376 DOI: 10.1111/j.1471-4159.2007.05179.x  0.316
2007 Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11139-48. PMID 17928456 DOI: 10.1523/JNEUROSCI.3364-07.2007  0.714
2007 Xu Y, Cai Y, Gong N, Chen C, Wu Y, Zhang-Nunes S, Wang Z, Xu T, Fei J. Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1. Biochemical and Biophysical Research Communications. 361: 499-504. PMID 17655829 DOI: 10.1016/J.Bbrc.2007.07.042  0.718
2007 Xu TL, Xiong ZG. Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators. Current Medicinal Chemistry. 14: 1753-63. PMID 17627513  0.308
2007 Ye JH, Gao J, Wu YN, Hu YJ, Zhang CP, Xu TL. Identification of acid-sensing ion channels in adenoid cystic carcinomas. Biochemical and Biophysical Research Communications. 355: 986-92. PMID 17324378 DOI: 10.1016/j.bbrc.2007.02.061  0.475
2007 Wang W, Yu Y, Xu TL. Modulation of acid-sensing ion channels by Cu(2+) in cultured hypothalamic neurons of the rat. Neuroscience. 145: 631-41. PMID 17224241 DOI: 10.1016/j.neuroscience.2006.12.009  0.309
2006 Nie DY, Ma QH, Law JW, Chia CP, Dhingra NK, Shimoda Y, Yang WL, Gong N, Chen QW, Xu G, Hu QD, Chow PK, Ng YK, Ling EA, Watanabe K, ... Xu TL, et al. Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp. Neuron Glia Biology. 2: 151-64. PMID 17364021 DOI: 10.1017/S1740925X06000251  0.671
2006 Tang ZQ, Lu YG, Zhou KQ, Xu TL, Chen L. Amiloride attenuates glycine-induced currents in cultured neurons of rat inferior colliculus. Biochemical and Biophysical Research Communications. 350: 900-4. PMID 17034762 DOI: 10.1016/J.Bbrc.2006.09.110  0.306
2006 Wang W, Wang H, Gong N, Xu TL. Changes of K+ -Cl- cotransporter 2 (KCC2) and circuit activity in propofol-induced impairment of long-term potentiation in rat hippocampal slices. Brain Research Bulletin. 70: 444-9. PMID 17027780 DOI: 10.1016/J.Brainresbull.2006.07.004  0.762
2006 Xu H, Wang W, Tang ZQ, Xu TL, Chen L. Taurine acts as a glycine receptor agonist in slices of rat inferior colliculus. Hearing Research. 220: 95-105. PMID 16949227 DOI: 10.1016/J.Heares.2006.07.005  0.362
2006 Wang W, Xu TL. Chloride homeostasis differentially affects GABA(A) receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture. Neuroscience Letters. 406: 11-6. PMID 16905250 DOI: 10.1016/j.neulet.2006.06.064  0.455
2006 Wu LJ, Xu TL. [Identification and functional implication of acid-sensing ion channels in rat spinal dorsal horn neurons]. Sheng Li Ke Xue Jin Zhan [Progress in Physiology]. 37: 135-7. PMID 16850619  0.534
2006 Jiang P, Yang CX, Wang YT, Xu TL. Mechanisms of modulation of pregnanolone on glycinergic response in cultured spinal dorsal horn neurons of rat. Neuroscience. 141: 2041-50. PMID 16806717 DOI: 10.1016/j.neuroscience.2006.05.009  0.361
2006 Wang DG, Gong N, Luo B, Xu TL. Absence of GABA type A signaling in adult medial habenular neurons. Neuroscience. 141: 133-41. PMID 16675141 DOI: 10.1016/J.Neuroscience.2006.03.045  0.733
2006 Guan QH, Pei DS, Liu XM, Wang XT, Xu TL, Zhang GY. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain Research. 1092: 36-46. PMID 16674927 DOI: 10.1016/j.brainres.2006.03.086  0.313
2006 Zhang LH, Xu L, Xu TL. Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats. Biochemical and Biophysical Research Communications. 344: 721-6. PMID 16631121 DOI: 10.1016/j.bbrc.2006.03.198  0.401
2006 Wang W, Gong N, Xu TL. Downregulation of KCC2 following LTP contributes to EPSP-spike potentiation in rat hippocampus. Biochemical and Biophysical Research Communications. 343: 1209-15. PMID 16581019 DOI: 10.1016/J.Bbrc.2006.03.038  0.732
2006 Yang CX, Xu H, Zhou KQ, Wang MY, Xu TL. Modulation of gamma-aminobutyric acid A receptor function by thiopental in the rat spinal dorsal horn neurons. Anesthesia and Analgesia. 102: 1114-20. PMID 16551908 DOI: 10.1213/01.ane.0000198657.76705.38  0.439
2006 Yang CX, Xu TL. Thiopental inhibits glycine receptor function in acutely dissociated rat spinal dorsal horn neurons. Neuroscience Letters. 397: 196-200. PMID 16406669 DOI: 10.1016/j.neulet.2005.12.020  0.42
2006 Pei DS, Wang XT, Liu Y, Sun YF, Guan QH, Wang W, Yan JZ, Zong YY, Xu TL, Zhang GY. Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Brain : a Journal of Neurology. 129: 465-79. PMID 16330502 DOI: 10.1093/brain/awh700  0.349
2006 Wang W, Duan B, Xu H, Xu L, Xu TL. Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead. The Journal of Biological Chemistry. 281: 2497-505. PMID 16319075 DOI: 10.1074/jbc.M507123200  0.603
2005 Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, et al. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11107-16. PMID 16319310 DOI: 10.1523/Jneurosci.1678-05.2005  0.583
2005 Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, Xu TL. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron. 48: 635-46. PMID 16301179 DOI: 10.1016/j.neuron.2005.10.011  0.675
2005 Pei DS, Guan QH, Sun YF, Zhang QX, Xu TL, Zhang GY. Neuroprotective effects of GluR6 antisense oligodeoxynucleotides on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 region. Journal of Neuroscience Research. 82: 642-9. PMID 16267825 DOI: 10.1002/jnr.20669  0.375
2005 Xu TX, Gong N, Xu TL. Divalent cation modulation of a-type potassium channels in acutely dissociated central neurons from wide-type and mutant Drosophila. Journal of Neurogenetics. 19: 87-107. PMID 16024441 DOI: 10.1080/01677060591007182  0.733
2005 Xu TX, Gong N, Xu TL. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission. Neuroreport. 16: 1227-31. PMID 16012354 DOI: 10.1097/00001756-200508010-00019  0.742
2005 Sun X, Zhang J, Li H, Zhang Z, Yang J, Cui M, Zeng B, Xu T, Cao J, Xu L. Propofol effects on excitatory synaptic efficacy in the CA1 region of the developing hippocampus. Brain Research. Developmental Brain Research. 157: 1-7. PMID 15939079 DOI: 10.1016/J.Devbrainres.2005.02.011  0.495
2005 Li H, Zhang J, Xiong W, Xu T, Cao J, Xu L. Long-term depression in rat CA1-subicular synapses depends on the G-protein coupled mACh receptors. Neuroscience Research. 52: 287-94. PMID 15893398 DOI: 10.1016/j.neures.2005.04.002  0.39
2005 Xu H, Gong N, Chen L, Xu TL. Sodium salicylate reduces gamma aminobutyric acid-induced current in rat spinal dorsal horn neurons. Neuroreport. 16: 813-6. PMID 15891576 DOI: 10.1097/00001756-200505310-00007  0.755
2004 Xu H, Zhou KQ, Huang YN, Chen L, Xu TL. Taurine activates strychnine-sensitive glycine receptors in neurons of the rat inferior colliculus. Brain Research. 1021: 232-40. PMID 15342271 DOI: 10.1016/J.Brainres.2004.07.001  0.414
2004 Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. The Journal of Biological Chemistry. 279: 43716-24. PMID 15302881 DOI: 10.1074/jbc.M403557200  0.778
2004 Gao J, Wu LJ, Xu L, Xu TL. Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neurons. Brain Research. 1017: 197-207. PMID 15261115 DOI: 10.1016/j.brainres.2004.05.046  0.624
2004 Cao J, Chen N, Xu T, Xu L. Stress-facilitated LTD induces output plasticity through synchronized-spikes and spontaneous unitary discharges in the CA1 region of the hippocampus. Neuroscience Research. 49: 229-39. PMID 15140565 DOI: 10.1016/j.neures.2004.03.001  0.309
2003 Li Y, Li YF, Xu TL. Amiloride inhibition of glycinergic miniature IPSCs in mechanically dissociated rat spinal neurons. Neuroscience Letters. 349: 17-20. PMID 12946576 DOI: 10.1016/S0304-3940(03)00672-4  0.448
2003 Li Y, Wu LJ, Legendre P, Xu TL. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. The Journal of Biological Chemistry. 278: 38637-45. PMID 12885784 DOI: 10.1074/Jbc.M303735200  0.604
2003 Li YF, Wu LJ, Li Y, Xu L, Xu TL. Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons. The Journal of Physiology. 552: 73-87. PMID 12855675 DOI: 10.1113/jphysiol.2003.047324  0.563
2003 Li YF, Li Y, Xu TL. Inhibition of glycine response by amiloride in rat spinal neurons. Neuroscience Letters. 345: 173-6. PMID 12842284 DOI: 10.1016/S0304-3940(03)00541-X  0.479
2003 Wu ZY, Xu TL. Taurine-evoked chloride current and its potentiation by intracellular Ca2+ in immature rat hippocampal CA1 neurons. Amino Acids. 24: 155-61. PMID 12624748 DOI: 10.1007/s00726-002-0314-8  0.312
2002 Xu TX, Lu H, Wang Q, Wu LJ, Liu J, Zhou Z, Xu TL. [Properties of whole-cell potassium currents in mechanically dissociated Drosophila larval central neurons]. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 54: 411-6. PMID 12399822  0.613
2002 Zhang ZX, Lü H, Dong XP, Liu J, Xu TL. Kinetics of etomidate actions on GABA(A) receptors in the rat spinal dorsal horn neurons. Brain Research. 953: 93-100. PMID 12384242 DOI: 10.1016/S0006-8993(02)03274-2  0.711
2002 Dong XP, Xu TL. The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesthesia and Analgesia. 95: 907-14, table of con. PMID 12351266 DOI: 10.1097/00000539-200210000-00021  0.717
2002 Lu H, Xu TL. The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons. The Journal of Biological Chemistry. 277: 41369-78. PMID 12196533 DOI: 10.1074/jbc.M206768200  0.491
2002 Gao J, Zhang JX, Xu TL. Modulation of serotonergic projection from dorsal raphe nucleus to basolateral amygdala on sleep-waking cycle of rats. Brain Research. 945: 60-70. PMID 12113952  0.321
2002 Dong XP, Xu TL. Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons. Brain Research. 940: 1-9. PMID 12020868 DOI: 10.1016/S0006-8993(02)02555-6  0.709
2002 Wu LJ, Li Y, Xu TL. Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. Neuroreport. 13: 977-81. PMID 12004203 DOI: 10.1097/00001756-200205240-00016  0.576
2002 Li Y, Xu TL. State-dependent cross-inhibition between anionic GABA(A) and glycine ionotropic receptors in rat hippocampal CA1 neurons. Neuroreport. 13: 223-6. PMID 11893914 DOI: 10.1097/00001756-200202110-00010  0.408
2001 Wu LJ, Lu Y, Xu TL. A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. Journal of Neuroscience Methods. 108: 199-206. PMID 11478979 DOI: 10.1016/S0165-0270(01)00404-6  0.508
1999 Xu TL, Li JS, Akaike N. Functional properties of ionotropic glutamate receptor channels in rat sacral dorsal commissural neurons. Neuropharmacology. 38: 659-70. PMID 10340303 DOI: 10.1016/S0028-3908(98)00227-5  0.76
1999 Nabekura J, Xu TL, Rhee JS, Li JS, Akaike N. Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons. Neuroscience. 89: 29-41. PMID 10051215 DOI: 10.1016/S0306-4522(98)00303-0  0.51
1999 Xu TL, Li JS, Jin YH, Akaike N. Modulation of the glycine response by Ca2+-permeable AMPA receptors in rat spinal neurones. The Journal of Physiology. 514: 701-11. PMID 9882741 DOI: 10.1111/J.1469-7793.1999.701Ad.X  0.788
1998 Xu TL, Pang ZP, Li JS, Akaike N. 5-HT potentiation of the GABA(A) response in the rat sacral dorsal commissural neurones. British Journal of Pharmacology. 124: 779-87. PMID 9690871 DOI: 10.1038/Sj.Bjp.0701896  0.427
1998 Wang DS, Xu TL, Pang ZP, Li JS, Akaike N. Taurine-activated chloride currents in the rat sacral dorsal commissural neurons. Brain Research. 792: 41-7. PMID 9593814 DOI: 10.1016/S0006-8993(98)00119-X  0.785
1997 Xu TL, Imanishi T, Akaike N. Modulation of the GABAA response in rat ventromedial hypothalamic neurons by pregnanolone. Comparative Biochemistry and Physiology. Part a, Physiology. 117: 219-26. PMID 9172380 DOI: 10.1016/S0300-9629(96)00288-5  0.48
1996 Xu TL, Nabekura J, Akaike N. Protein kinase C-mediated enhancement of glycine response in rat sacral dorsal commissural neurones by serotonin. The Journal of Physiology. 496: 491-501. PMID 8910232 DOI: 10.1113/Jphysiol.1996.Sp021701  0.401
1995 Lü Y, Jin SX, Xu TL, Qin BZ, Li JS, Ding YQ, Shigemoto R, Mizuno N. Expression of c-fos protein in substance P receptor-like immunoreactive neurons in response to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord segments of the rat. Neuroscience Letters. 198: 139-42. PMID 8592640 DOI: 10.1016/0304-3940(95)11991-5  0.704
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