Brian Y Lam, PhD - Publications

Affiliations: 
University of Cambridge, Cambridge, England, United Kingdom 
Area:
Genomics

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Yu X, Newland SA, Zhao TX, Lu Y, Sage AS, Sun Y, Sriranjan RS, Ma MKL, Lam BYH, Nus M, Harrison JE, Bond SJ, Cheng X, Silvestre JS, Rudd JHF, et al. Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction. Journal of the American College of Cardiology. 78: 1127-1142. PMID 34503682 DOI: 10.1016/j.jacc.2021.07.018  1
2021 Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, et al. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Scientific Reports. 11: 17571. PMID 34475432 DOI: 10.1038/s41598-021-96278-8  1
2021 Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM. High co-expression of the ghrelin and LEAP2 receptor GHSR with pancreatic polypeptide in mouse and human islets. Endocrinology. PMID 34289060 DOI: 10.1210/endocr/bqab148  1
2021 Wade KH, Lam BYH, Melvin A, Pan W, Corbin LJ, Hughes DA, Rainbow K, Chen JH, Duckett K, Liu X, Mokrosiński J, Mörseburg A, Neaves S, Williamson A, Zhang C, et al. Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort. Nature Medicine. PMID 34045736 DOI: 10.1038/s41591-021-01349-y  1
2021 Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, Polex-Wolf J, Knudsen LB, Pyke C, Yeo GSH. A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing. Molecular Metabolism. 101240. PMID 33962048 DOI: 10.1016/j.molmet.2021.101240  1
2021 Quiñones M, Hernández-Bautista R, Beiroa D, Heras V, Torres-Leal FL, Lam BYH, Senra A, Fernø J, Gómez-Valadés AG, Schwaninger M, Prevot V, Yeo G, Claret M, López M, Diéguez C, et al. Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner. Redox Biology. 41: 101945. PMID 33744652 DOI: 10.1016/j.redox.2021.101945  1
2021 Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Frontiers in Pharmacology. 12: 618773. PMID 33643049 DOI: 10.3389/fphar.2021.618773  1
2021 Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink DA, Jenkins B, Koulman A, Brighton CA, Ma M, Lam BYH, Coll AP, O'Rahilly S, Reimann F, Gribble FM. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Scientific Reports. 11: 2529. PMID 33510216 DOI: 10.1038/s41598-021-81349-7  1
2020 Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. Plos Genetics. 16: e1009069. PMID 33057429 DOI: 10.1371/journal.pgen.1009069  0.01
2020 Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, et al. Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis. Nature Metabolism. 2: 514-531. PMID 32694734 DOI: 10.1038/s42255-020-0214-9  0.01
2020 Ma Y, Ratnasabapathy R, De Backer I, Izzi-Engbeaya C, Nguyen-Tu MS, Cuenco J, Jones B, John CD, Lam BYH, Rutter GA, Yeo G, Dhillo W, Gardiner J. Glucose in the hypothalamic pataventricular nucleus regulates GLP-1 release. Jci Insight. PMID 32229720 DOI: 10.1172/Jci.Insight.132760  0.01
2020 Georgescu T, Lyons D, Doslikova B, Garcia AP, Marston O, Burke LK, Chianese R, Lam BYH, Yeo GSH, Rochford JJ, Garfield AS, Heisler LK. Neurochemical characterization of brainstem Pro-opiomelanocortin cells. Endocrinology. PMID 32166324 DOI: 10.1210/Endocr/Bqaa032  1
2019 Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells. Molecular Metabolism. 29: 158-169. PMID 31668387 DOI: 10.1016/J.Molmet.2019.09.001  1
2019 Clément M, Raffort J, Lareyre F, Tsiantoulas D, Newland SA, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MK, Ozsvar-Kozma M, Lam B, Yeo GS, Binder CJ, Kaser A, et al. Impaired Autophagy in CD11b Dendritic Cells Expands CD4 Regulatory T Cells And Limits Atherosclerosis in Mice. Circulation Research. PMID 31610723 DOI: 10.1161/Circresaha.119.315248  1
2019 Al-Massadi O, Quiñones M, Clasadonte J, Bautista RH, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, ... ... Lam BYH, et al. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity and Glucose Intolerance. Diabetes. PMID 31530579 DOI: 10.2337/Db19-0029  1
2019 Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Molecular Metabolism. PMID 31176677 DOI: 10.1016/J.Molmet.2019.05.008  1
2019 Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, et al. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. PMID 30733330 DOI: 10.2337/Db18-0883  1
2018 Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, et al. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nature Communications. 9: 3432. PMID 30143607 DOI: 10.1038/S41467-018-05711-6  1
2018 Basatemur G, Ackers-Johnson M, Schoonejans J, Kazachenka A, Lam B, Ma M, Brimpari M, Patel M, Saleh N, Murphy D, Zhao T, Yeo G, Ferguson-Smith A, Vallier L, Sinha S, et al. 129 The CHR9P21 risk locus affects IL-1/TLR signalling in VSMC Heart. 104. DOI: 10.1136/Heartjnl-2018-Bcs.128  1
2017 Larder R, Sim MFM, Gulati P, Antrobus R, Tung YCL, Rimmington D, Ayuso E, Polex-Wolf J, Lam BYH, Dias C, Logan DW, Virtue S, Bosch F, Yeo GSH, Saudek V, et al. Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28811369 DOI: 10.1073/Pnas.1707310114  1
2017 Challis BG, Powlson AS, Casey RT, Pearson C, Lam B, Ma M, Pitfield D, Yeo G, Godfrey E, Cheow H, Chatterjee VK, Carroll N, Shaw A, Buscombe J, Simpson HL. Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management. Endocrine Connections. PMID 28784625 DOI: 10.1530/Ec-17-0076  1
2017 Shek FH, Luo R, Lam BYH, Sung WK, Lam TW, Luk JM, Leung MS, Chan KT, Wang HK, Chan CM, Poon RT, Lee NP. Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma. Cellular Oncology (Dordrecht). PMID 28631187 DOI: 10.1007/S13402-017-0332-X  1
2017 Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, et al. Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Reports. 19: 2202-2209. PMID 28614708 DOI: 10.1016/J.Celrep.2017.05.066  1
2017 Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O'Rahilly S, Coll AP, Yeo GSH. Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing. Molecular Metabolism. 6: 383-392. PMID 28462073 DOI: 10.1016/J.Molmet.2017.02.007  1
2017 Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, et al. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nature Medicine. PMID 28414328 DOI: 10.1038/Nm.4315  1
2017 Langdon WB, Lam BY, Modat M, Petke J, Harman M. Genetic improvement of GPU software Genetic Programming and Evolvable Machines. 18: 5-44. DOI: 10.1007/S10710-016-9273-9  0.01
2016 Zhou J, Lam B, Neogi SG, Yeo GS, Azizan EA, Brown MJ. Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues. Hypertension (Dallas, Tex. : 1979). PMID 27777363 DOI: 10.1161/Hypertensionaha.116.08033  1
2016 Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia. PMID 27390011 DOI: 10.1007/S00125-016-4033-1  1
2016 Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, et al. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metabolism. PMID 27133129 DOI: 10.1016/J.Cmet.2016.04.003  1
2016 Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, ... ... Lam B, et al. Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 164: 353-364. PMID 26824653 DOI: 10.1016/J.Cell.2015.12.025  1
2015 Ye L, Goodall JC, Zhang L, Putintseva EV, Lam B, Jiang L, Liu W, Yin J, Lin L, Li T, Wu X, Yeo G, Shugay M, Chudakov DM, Gaston H, et al. TCR usage, gene expression and function of two distinct FOXP3+Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO. Immunology and Cell Biology. PMID 26467610 DOI: 10.1038/Icb.2015.90  1
2014 Tucka J, Yu H, Gray K, Figg N, Maguire J, Lam B, Bennett M, Littlewood T. Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2421-8. PMID 25234814 DOI: 10.1161/Atvbaha.114.304284  0.01
2014 Schlosberg A, Lam BY, Yeo GS, Clifton-Bligh RJ. DEFLATE compression algorithm corrects for overestimation of phylogenetic diversity by Grantham approach to single-nucleotide polymorphism classification. International Journal of Molecular Sciences. 15: 8491-508. PMID 24828207 DOI: 10.3390/Ijms15058491  1
2012 Azizan EA, Lam BY, Newhouse SJ, Zhou J, Kuc RE, Clarke J, Happerfield L, Marker A, Hoffman GJ, Brown MJ. Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors. The Journal of Clinical Endocrinology and Metabolism. 97: E819-29. PMID 22442279 DOI: 10.1210/Jc.2011-2965  1
2012 Azizan E, Lam B, Newhouse S, Zhou J, Kuc R, Clarke J, Happerfield L, Marker A, Hoffman G, Brown M. 802 Somatic Mutations Of Kcnj5 Are Common In Aldosterone-Producing Adenomas Of The Adrenal, And Distinguish A Phenotype Of Younger Women With Zf-Like Large Adenomas From Older Men With Zg-Like Small Adenomas Journal of Hypertension. 30. DOI: 10.1097/01.Hjh.0000420834.09461.6E  1
2011 Gumy LF, Yeo GS, Tung YC, Zivraj KH, Willis D, Coppola G, Lam BY, Twiss JL, Holt CE, Fawcett JW. Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization. Rna (New York, N.Y.). 17: 85-98. PMID 21098654 DOI: 10.1261/Rna.2386111  1
2011 Kempster SL, Belteki G, Forhead AJ, Fowden AL, Catalano RD, Lam BY, McFarlane I, Charnock-Jones DS, Smith GC. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G253-63. PMID 21088234 DOI: 10.1152/Ajpgi.00397.2010  0.01
2010 Burchard J, Zhang C, Liu AM, Poon RT, Lee NP, Wong KF, Sham PC, Lam BY, Ferguson MD, Tokiwa G, Smith R, Leeson B, Beard R, Lamb JR, Lim L, et al. microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma. Molecular Systems Biology. 6: 402. PMID 20739924 DOI: 10.1038/Msb.2010.58  1
2010 Chen L, Ho DW, Lee NP, Sun S, Lam B, Wong KF, Yi X, Lau GK, Ng EW, Poon TC, Lai PB, Cai Z, Peng J, Leng X, Poon RT, et al. Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker. Annals of Surgical Oncology. 17: 2518-25. PMID 20354800 DOI: 10.1245/S10434-010-1038-8  1
2010 Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, et al. Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radical Biology & Medicine. 48: 161-72. PMID 19854266 DOI: 10.1016/j.freeradbiomed.2009.10.039  1
2008 Lee NP, Leung KW, Cheung N, Lam BY, Xu MZ, Sham PC, Lau GK, Poon RT, Fan ST, Luk JM. Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma. Proteomics. 8: 2136-49. PMID 18425728 DOI: 10.1002/Pmic.200700590  1
2007 Luk JM, Lam BY, Lee NP, Ho DW, Sham PC, Chen L, Peng J, Leng X, Day PJ, Fan ST. Artificial neural networks and decision tree model analysis of liver cancer proteomes. Biochemical and Biophysical Research Communications. 361: 68-73. PMID 17644064 DOI: 10.1016/J.Bbrc.2007.06.172  1
2006 Wang XQ, Luk JM, Garcia-Barcelo M, Miao X, Leung PP, Ho DW, Cheung ST, Lam BY, Cheung CK, Wong AS, Lau SS, So MT, Yu WC, Cai Q, Liu KS, et al. Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5248-52. PMID 16951245 DOI: 10.1158/1078-0432.Ccr-06-0558  1
2006 Luk JM, Lee NP, Shum CK, Lam BY, Siu AF, Che CM, Tam PC, Cheung AN, Yang ZM, Lin YN, Matzuk MM, Lee KF, Yeung WS. Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis. Journal of Cellular Physiology. 209: 755-66. PMID 16924657 DOI: 10.1002/Jcp.20746  1
2006 Luk JM, Lam CT, Siu AF, Lam BY, Ng IO, Hu MY, Che CM, Fan ST. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values. Proteomics. 6: 1049-57. PMID 16400691 DOI: 10.1002/Pmic.200500306  1
2002 Ko KM, Lam BY. Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain. Molecular and Cellular Biochemistry. 238: 181-6. PMID 12349905  0.01
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