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Mark G. McLaughlin - Publications

Affiliations: 
2010-2014 Queen's University Belfast, Belfast, Northern Ireland, United Kingdom 
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chen CY, Lu Z, Scattolin T, Chen C, Gan Y, McLaughlin M. Synthesis of (MRTX849), a Covalent KRAS Inhibitor Drug for the Treatment of Cancer. Organic Letters. PMID 36723667 DOI: 10.1021/acs.orglett.2c04266  0.352
2022 Roberts DD, McLaughlin MG. Diastereoselective access to substituted oxetanes hydrosilylation-iodocyclisation of homopropargylic alcohols. Chemical Communications (Cambridge, England). PMID 35792361 DOI: 10.1039/d2cc03339a  0.327
2022 Basson AJ, Halcovitch NR, McLaughlin MG. Unified Approach to Diverse Fused Fragments via Catalytic Dehydrative Cyclization. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 35642626 DOI: 10.1002/chem.202201107  0.379
2021 Roberts DD, McLaughlin MG. Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds. Organic Letters. 23: 4463-4467. PMID 34018758 DOI: 10.1021/acs.orglett.1c01398  0.441
2021 Basson AJ, McLaughlin MG. Sustainable Access to 5-Amino-Oxazoles and Thiazoles via Calcium-Catalyzed Elimination-Cyclization with Isocyanides. Chemsuschem. PMID 33605021 DOI: 10.1002/cssc.202100225  0.361
2020 Whittaker A, Patel NR, Huffman MA, Wang X, Ding B, McLaughlin M, Newman JA, Andreani T, Maloney KM, Johnson HC. Five-Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32710473 DOI: 10.1002/chem.202003091  0.314
2020 Patel NR, Nawrat CC, McLaughlin M, Xu Y, Huffman MA, Yang H, Li H, Whittaker AM, Andreani T, Lévesque F, Fryszkowska A, Brunskill A, Tschaen DM, Maloney KM. Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone. Organic Letters. PMID 32516536 DOI: 10.1021/Acs.Orglett.0C01431  0.405
2020 Basson AJ, McLaughlin MG. Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of -Acyliminium Ions. The Journal of Organic Chemistry. 85: 5615-5628. PMID 32208694 DOI: 10.1021/Acs.Joc.0C00482  0.377
2020 Nawrat CC, Whittaker AM, Huffman MA, McLaughlin M, Cohen RD, Andreani T, Ding B, Li H, Weisel M, Tschaen DM. Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose. Organic Letters. PMID 32108487 DOI: 10.1021/acs.orglett.0c00239  0.319
2020 Britten TK, McLaughlin MG. Brønsted Acid Catalyzed Peterson Olefinations. The Journal of Organic Chemistry. 85: 301-305. PMID 31775003 DOI: 10.1021/Acs.Joc.9B02489  0.431
2019 Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, ... ... McLaughlin M, et al. Design of an in vitro biocatalytic cascade for the manufacture of islatravir. Science (New York, N.Y.). 366: 1255-1259. PMID 31806816 DOI: 10.1126/Science.Aay8484  0.34
2019 Basson AJ, McLaughlin MG. Functionalisation of isoindolinones via a calcium catalysed Hosomi-Sakurai allylation. Chemical Communications (Cambridge, England). 55: 8317-8320. PMID 31257381 DOI: 10.1039/C9Cc02450F  0.394
2018 Kiely-Collins HJ, Sechi I, Brennan PE, McLaughlin MG. Mild, calcium catalysed Beckmann rearrangements. Chemical Communications (Cambridge, England). 54: 654-657. PMID 29300400 DOI: 10.1039/C7Cc09491D  0.45
2018 Kerr WJ, McLaughlin M, Paterson LC, Pearson CM. Total synthesis 2-epi-α-cedren-3-one via a cobalt-catalysed Pauson-Khand reaction Tetrahedron. 74: 5062-5068. DOI: 10.1016/J.Tet.2018.06.032  0.558
2017 Peng F, Chen Y, Chen CY, Dormer PG, Kassim A, McLaughlin M, Reamer RA, Sherer EC, Song ZJ, Tan L, Tudge MT, Wan B, Chung JYL. Asymmetric Formal Synthesis of the Long-acting DPP-4 Inhibitor Omarigliptin. The Journal of Organic Chemistry. PMID 28776371 DOI: 10.1021/Acs.Joc.7B01467  0.464
2016 Mullens P, Cleator E, McLaughlin M, Bishop B, Edwards J, Goodyear A, Andreani T, Jin Y, Kong J, Li H, Williams M, Zacuto M. Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate Organic Process Research & Development. 20: 1075-1087. DOI: 10.1021/Acs.Oprd.6B00136  0.431
2015 Kong J, McLaughlin M, Belyk K, Mondschein R. Enantioselective Rh(I)-Catalyzed Addition of Arylboronic Acids to Cyclic Ketimines. Organic Letters. PMID 26542775 DOI: 10.1021/Acs.Orglett.5B02032  0.331
2015 McLaughlin MG, McAdam CA, Cook MJ. MIDA-vinylsilanes: selective cross-couplings and applications to the synthesis of functionalized stilbenes. Organic Letters. 17: 10-3. PMID 25513732 DOI: 10.1021/Ol503065A  0.419
2015 McAdam CA, McLaughlin MG, Cook MJ. An alkyne hydrosilylation-Hiyama coupling approach to highly functionalised 1,3-dienes Organic Chemistry Frontiers. 2: 510-514. DOI: 10.1039/C5Qo00002E  0.376
2014 McLaughlin MG, Cook MJ. Highly diastereoselective hydrosilylations of allylic alcohols. Chemical Communications (Cambridge, England). 50: 3501-4. PMID 24557001 DOI: 10.1039/C4Cc00138A  0.32
2013 Johnston AJ, McLaughlin MG, Reid JP, Cook MJ. NaH mediated isomerisation-allylation reaction of 1,3-substituted propenols. Organic & Biomolecular Chemistry. 11: 7662-6. PMID 24108362 DOI: 10.1039/C3Ob41857J  0.452
2013 McAdam CA, McLaughlin MG, Johnston AJ, Chen J, Walter MW, Cook MJ. Platinum catalysed hydrosilylation of propargylic alcohols. Organic & Biomolecular Chemistry. 11: 4488-502. PMID 23715614 DOI: 10.1039/C3Ob40496J  0.42
2013 McLaughlin M, Belyk K, Chen CY, Linghu X, Pan J, Qian G, Reamer RA, Xu Y. Practical asymmetric synthesis of a chiral piperazinone derivative Organic Process Research and Development. 17: 1052-1060. DOI: 10.1021/Op400150W  0.388
2012 Zhong YL, Gauthier DR, Shi YJ, McLaughlin M, Chung JY, Dagneau P, Marcune B, Krska SW, Ball RG, Reamer RA, Yasuda N. Synthesis of antifungal glucan synthase inhibitors from enfumafungin. The Journal of Organic Chemistry. 77: 3297-310. PMID 22423625 DOI: 10.1021/Jo300046V  0.468
2012 McLaughlin MG, Cook MJ. Domino alkene-isomerization-Claisen rearrangement strategy to substituted allylsilanes. The Journal of Organic Chemistry. 77: 2058-63. PMID 22235747 DOI: 10.1021/Jo202560G  0.456
2012 Flanagan JCA, Dornan LM, McLaughlin MG, McCreanor NG, Cook MJ, Muldoon MJ. The synthesis of N-heterocycles via copper/TEMPO catalysed aerobic oxidation of amino alcohols Green Chemistry. 14: 1281. DOI: 10.1039/C2Gc35062A  0.353
2011 McLaughlin MG, Cook MJ. PtCl2/XPhos: a highly efficient and readily available catalyst for the hydrosilylation of propargylic alcohols. Chemical Communications (Cambridge, England). 47: 11104-6. PMID 21909537 DOI: 10.1039/C1Cc14433B  0.385
2009 Xu Y, McLaughlin M, Chen CY, Reamer RA, Dormer PG, Davies IW. A general method for the synthesis of 3,5-diarylcyclopentenones via friedel-crafts acylation of vinyl chlorides. The Journal of Organic Chemistry. 74: 5100-3. PMID 19485346 DOI: 10.1021/jo900696k  0.337
2007 McLaughlin M, Palucki M, Davies IW. Efficient access to cyclic ureas via Pd-catalyzed cyclization. Organic Letters. 8: 3311-4. PMID 16836393 DOI: 10.1021/ol061233j  0.333
2007 McLaughlin M, Palucki M, Davies IW. Efficient access to azaindoles and indoles. Organic Letters. 8: 3307-10. PMID 16836392 DOI: 10.1021/ol061232r  0.319
2005 Amato JS, Chung JY, Cvetovich RJ, Gong X, McLaughlin M, Reamer RA. Synthesis of 1-tert-butyl-4-chloropiperidine: generation of an N-tert-butyl group by the reaction of a dimethyliminium salt with methylmagnesium chloride. The Journal of Organic Chemistry. 70: 1930-3. PMID 15730326 DOI: 10.1021/Jo048047G  0.488
2003 McLaughlin M, Mohareb RM, Rapoport H. An efficient procedure for the preparation of 4-substituted 5-aminoimidazoles. The Journal of Organic Chemistry. 68: 50-4. PMID 12515460 DOI: 10.1021/Jo026257S  0.337
2001 Kerr WJ, McLaughlin M, Morrison AJ, Pauson PL. Formal total synthesis of (+/-)-alpha- and beta-cedrene by preparation of cedrone. Construction of the tricyclic carbon skeleton by the use of a highly efficient intramolecular Khand annulation. Organic Letters. 3: 2945-8. PMID 11554814 DOI: 10.1021/Ol016054A  0.526
1986 Deutsch HM, Gelbaum LT, McLaughlin M, Fleischmann TJ, Earnhart LL, Haugwitz RD, Zalkow LH. Synthesis of congeners and prodrugs of the benzene maleimide photoadduct mitindomide as potential antitumor agents. 2. Journal of Medicinal Chemistry. 29: 2164-70. PMID 3783577 DOI: 10.1021/Jm00161A006  0.331
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