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Nadine Darwiche - Publications

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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Al Hadeethi S, El-Baba C, Araji K, Hayar B, Cheikh IA, El-Khoury R, Usta J, Darwiche N. Mannose Inhibits the Pentose Phosphate Pathway in Colorectal Cancer and Enhances Sensitivity to 5-Fluorouracil Therapy. Cancers. 15. PMID 37190196 DOI: 10.3390/cancers15082268  0.588
2022 Cheikh IA, El-Baba C, Youssef A, Saliba NA, Ghantous A, Darwiche N. Lessons learned from the discovery and development of the sesquiterpene lactones in cancer therapy and prevention. Expert Opinion On Drug Discovery. 17: 1377-1405. PMID 36373806 DOI: 10.1080/17460441.2023.2147920  0.47
2022 Hamze K, Abdallah RH, Younis NK, Fardoun M, Darwiche N, Kobeissy F, Iratni R, Bouhadir K, Eid AH. 2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells. Current Medicinal Chemistry. PMID 36111761 DOI: 10.2174/0929867329666220914112042  0.567
2022 Assi S, Hajj HE, Hayar B, Pisano C, Saad W, Darwiche N. Development and Challenges of Synthetic Retinoid Formulations in Cancer. Current Drug Delivery. PMID 35950256 DOI: 10.2174/1567201819666220810094708  0.47
2021 Ghanem N, El-Baba C, Araji K, El-Khoury R, Usta J, Darwiche N. The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities. Chemotherapy. 66: 179-191. PMID 34775382 DOI: 10.1159/000519784  0.382
2021 Dallavalle S, Musso L, Cincinelli R, Darwiche N, Gervasoni S, Vistoli G, Guglielmi MB, La Porta I, Pizzulo M, Modica E, Prosperi F, Signorino G, Colelli F, Cardile F, Fucci A, et al. Antitumor activity of novel POLA1-HDAC11 dual inhibitors. European Journal of Medicinal Chemistry. 113971. PMID 34772529 DOI: 10.1016/j.ejmech.2021.113971  0.319
2021 Ghandour B, Dbaibo G, Darwiche N. The unfolding role of ceramide in coordinating retinoid-based cancer therapy. The Biochemical Journal. 478: 3621-3642. PMID 34648006 DOI: 10.1042/BCJ20210368  0.474
2021 El-Baba C, Baassiri A, Kiriako G, Dia B, Fadlallah S, Moodad S, Darwiche N. Terpenoids' anti-cancer effects: focus on autophagy. Apoptosis : An International Journal On Programmed Cell Death. PMID 34269920 DOI: 10.1007/s10495-021-01684-y  0.445
2021 Karam L, Abou Staiteieh S, Chaaban R, Hayar B, Ismail B, Neipel F, Darwiche N, Abou Merhi R. Anticancer activities of parthenolide in primary effusion lymphoma preclinical models. Molecular Carcinogenesis. PMID 34101920 DOI: 10.1002/mc.23324  0.311
2020 Cincinelli R, Musso L, Guglielmi MB, La Porta I, Fucci A, Luca D'Andrea E, Cardile F, Colelli F, Signorino G, Darwiche N, Gervasoni S, Vistoli G, Pisano C, Dallavalle S. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorganic Chemistry. 104: 104253. PMID 32920362 DOI: 10.1016/j.bioorg.2020.104253  0.473
2020 Cincinelli R, Musso L, Guglielmi MB, La Porta I, Fucci A, Luca D'Andrea E, Cardile F, Colelli F, Signorino G, Darwiche N, Gervasoni S, Vistoli G, Pisano C, Dallavalle S. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorganic Chemistry. 104: 104253. PMID 32920362 DOI: 10.1016/j.bioorg.2020.104253  0.473
2020 Ballout F, Monzer A, Fatfat M, Ouweini HE, Jaffa MA, Abdel-Samad R, Darwiche N, Abou-Kheir W, Gali-Muhtasib H. Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells. Oncotarget. 11: 2959-2972. PMID 32821342 DOI: 10.18632/Oncotarget.27426  0.491
2020 Darwiche N. Epigenetic mechanisms and the hallmarks of cancer: an intimate affair. American Journal of Cancer Research. 10: 1954-1978. PMID 32774995  0.446
2019 Abdel-Samad R, Aouad P, Darwiche N. Natural and synthetic retinoids in preclinical colorectal cancer models. Anti-Cancer Drugs. PMID 31021825 DOI: 10.1097/CAD.0000000000000802  0.471
2019 Bahmad HF, Samman H, Monzer A, Hadadeh O, Cheaito K, Abdel-Samad R, Hayar B, Pisano C, Msheik H, Liu YN, Darwiche N, Abou-Kheir W. The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells. Molecular Carcinogenesis. PMID 30883933 DOI: 10.1002/Mc.23004  0.491
2018 Abdel-Samad R, Aouad P, Gali-Muhtasib H, Sweidan Z, Hmadi R, Kadara H, D'Andrea EL, Fucci A, Pisano C, Darwiche N. Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α. American Journal of Cancer Research. 8: 39-55. PMID 29416919  0.483
2018 Karam L, Houshaymi B, Abdel-Samad R, Jaafar M, Halloum I, Pisano C, Neipel F, Darwiche N, Abou Merhi R. Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models. Oncology Reports. 39: 721-730. PMID 29207182 DOI: 10.3892/or.2017.6137  0.363
2017 El-Houjeiri L, Saad W, Hayar B, Aouad P, Tawil N, Abdel-Samad R, Hleihel R, Hamie M, Mancinelli A, Pisano C, El Hajj H, Darwiche N. Antitumor Effect of the Atypical Retinoid ST1926 in Acute Myeloid Leukemia and Nanoparticle Formulation Prolongs Lifespan and Reduces Tumor Burden of Xenograft Mice. Molecular Cancer Therapeutics. PMID 28619754 DOI: 10.1158/1535-7163.Mct-16-0785  0.327
2017 Aouad P, Saikali M, Abdel-Samad R, Fostok S, El-Houjeiri L, Pisano C, Talhouk R, Darwiche N. Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models. Anti-Cancer Drugs. 28: 757-770. PMID 28471809 DOI: 10.1097/CAD.0000000000000511  0.455
2016 Basma H, Ghayad SE, Rammal G, Mancinelli A, Harajly M, Ghamloush F, Dweik L, El-Eit R, Zalzali H, Rabeh W, Pisano C, Darwiche N, Saab R. The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma. International Journal of Cancer. 138: 1528-37. PMID 26453552 DOI: 10.1002/ijc.29886  0.357
2015 Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N. Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 20: 1531-62. PMID 26362468 DOI: 10.1007/s10495-015-1169-2  0.507
2015 Nasr RR, Hmadi RA, El-Eit RM, Iskandarani AN, Jabbour MN, Zaatari GS, Mahon FX, Pisano CC, Darwiche ND. ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model. International Journal of Cancer. 137: 698-709. PMID 25557649 DOI: 10.1002/ijc.29407  0.314
2013 Tohme R, Al Aaraj L, Ghaddar T, Gali-Muhtasib H, Saliba NA, Darwiche N. Differential growth inhibitory effects of highly oxygenated guaianolides isolated from the Middle Eastern indigenous plant Achillea falcata in HCT-116 colorectal cancer cells. Molecules (Basel, Switzerland). 18: 8275-88. PMID 23860275 DOI: 10.3390/molecules18078275  0.516
2013 Ghantous A, Sinjab A, Herceg Z, Darwiche N. Parthenolide: from plant shoots to cancer roots. Drug Discovery Today. 18: 894-905. PMID 23688583 DOI: 10.1016/J.Drudis.2013.05.005  0.565
2013 Salla M, Fakhoury I, Saliba N, Darwiche N, Gali-Muhtasib H. Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide. Journal of Natural Medicines. 67: 468-79. PMID 22976170 DOI: 10.1007/s11418-012-0703-6  0.474
2012 Ghantous A, Saikali M, Rau T, Gali-Muhtasib H, Schneider-Stock R, Darwiche N. Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21. Cancer Prevention Research (Philadelphia, Pa.). 5: 1298-309. PMID 23037503 DOI: 10.1158/1940-6207.CAPR-12-0230  0.418
2012 Saikali M, Ghantous A, Halawi R, Talhouk SN, Saliba NA, Darwiche N. Sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells. Bmc Complementary and Alternative Medicine. 12: 89. PMID 22776414 DOI: 10.1186/1472-6882-12-89  0.33
2012 Schneider-Stock R, Ghantous A, Bajbouj K, Saikali M, Darwiche N. Epigenetic mechanisms of plant-derived anticancer drugs. Frontiers in Bioscience (Landmark Edition). 17: 129-73. PMID 22201736  0.401
2011 Tohme R, Darwiche N, Gali-Muhtasib H. A journey under the sea: the quest for marine anti-cancer alkaloids. Molecules (Basel, Switzerland). 16: 9665-96. PMID 22113577 DOI: 10.3390/molecules16119665  0.559
2010 Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N. What made sesquiterpene lactones reach cancer clinical trials? Drug Discovery Today. 15: 668-78. PMID 20541036 DOI: 10.1016/j.drudis.2010.06.002  0.554
2009 Ghantous A, Nasser N, Saab I, Darwiche N, Saliba NA. Structure-activity relationship of seco-tanapartholides isolated from Achillea falcata for inhibition of HaCaT cell growth. European Journal of Medicinal Chemistry. 44: 3794-7. PMID 19464086 DOI: 10.1016/j.ejmech.2009.04.029  0.372
2008 Ghantous A, Tayyoun AA, Lteif GA, Saliba NA, Gali-Muhtasib H, El-Sabban M, Darwiche N. Purified salograviolide A isolated from centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells. International Journal of Oncology. 32: 841-9. PMID 18360711  0.389
2008 El-Najjar N, Dakdouki S, Darwiche N, El-Sabban M, Saliba NA, Gali-Muhtasib H. Anti-colon cancer effects of Salograviolide A isolated from Centaurea ainetensis. Oncology Reports. 19: 897-904. PMID 18357373  0.601
2007 Darwiche N, El-Banna S, Gali-Muhtasib H. Cell cycle modulatory and apoptotic effects of plant-derived anticancer drugs in clinical use or development. Expert Opinion On Drug Discovery. 2: 361-79. PMID 23484647 DOI: 10.1517/17460441.2.3.361  0.338
2007 Glick A, Ryscavage A, Perez-Lorenzo R, Hennings H, Yuspa S, Darwiche N. The high-risk benign tumor: Evidence from the two-stage skin cancer model and relevance for human cancer Molecular Carcinogenesis. 46: 605-610. PMID 17538943 DOI: 10.1002/Mc.20345  0.331
2005 Darwiche N, Abou-Lteif G, Najdi T, Kozhaya L, Tayoun AA, Abou Tayyoun A, Bazarbachi A, Dbaibo GS. Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide. The Biochemical Journal. 392: 231-9. PMID 16086670 DOI: 10.1042/BJ20050578  0.327
2004 Kabbout M, Hatoum A, Abou-Lteif G, Chakroun I, Homaidan FR, Darwiche N. Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis. Molecular Carcinogenesis. 40: 12-23. PMID 15108326 DOI: 10.1002/mc.20016  0.413
2004 Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anti-Cancer Drugs. 15: 389-99. PMID 15057144 DOI: 10.1097/00001813-200404000-00012  0.337
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