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Jeffrey R. Simard, Ph.D. - Publications

Affiliations: 
2006 Boston University, Boston, MA, United States 
Area:
General Biophysics, Pharmacology, Animal Physiology Biology
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jay AG, Simard JR, Huang N, Hamilton JA. SSO and other inhibitors of putative fatty acid (FA) transport do not affect FA transport but disrupt FA metabolism. Journal of Lipid Research. PMID 32102800 DOI: 10.1194/Jlr.Ra120000648  0.58
2016 Becker C, Öcal S, Nguyen HD, Phan T, Keul M, Simard JR, Rauh D. Monitoring conformational changes in the receptor tyrosine kinase EGFR. Chembiochem : a European Journal of Chemical Biology. PMID 26991964 DOI: 10.1002/Cbic.201600115  0.387
2015 Fang Z, Simard JR, Plenker D, Nguyen HD, Phan T, Wolle P, Baumeister S, Rauh D. Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. Acs Chemical Biology. 10: 279-88. PMID 24959717 DOI: 10.1021/Cb500355C  0.413
2014 Simard JR, Rauh D. FLiK: a direct-binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations. Methods in Enzymology. 548: 147-71. PMID 25399645 DOI: 10.1016/B978-0-12-397918-6.00006-9  0.442
2014 Richters A, Nguyen HD, Phan T, Simard JR, Grütter C, Engel J, Rauh D. Identification of type II and III DDR2 inhibitors. Journal of Medicinal Chemistry. 57: 4252-62. PMID 24754677 DOI: 10.1021/Jm500167Q  0.393
2013 Schneider R, Gohla A, Simard JR, Yadav DB, Fang Z, van Otterlo WA, Rauh D. Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores. Journal of the American Chemical Society. 135: 8400-8. PMID 23672540 DOI: 10.1021/Ja403074J  0.421
2013 Schneider R, Beumer C, Simard JR, Grütter C, Rauh D. Selective detection of allosteric phosphatase inhibitors. Journal of the American Chemical Society. 135: 6838-41. PMID 23611635 DOI: 10.1021/Ja4030484  0.439
2012 Getlik M, Simard JR, Termathe M, Grütter C, Rabiller M, van Otterlo WA, Rauh D. Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38α kinase. Plos One. 7: e39713. PMID 22768308 DOI: 10.1371/Journal.Pone.0039713  0.46
2012 Schneider R, Becker C, Simard JR, Getlik M, Bohlke N, Janning P, Rauh D. Direct binding assay for the detection of type IV allosteric inhibitors of Abl. Journal of the American Chemical Society. 134: 9138-41. PMID 22612329 DOI: 10.1021/Ja303858W  0.415
2012 Grütter C, Simard JR, Mayer-Wrangowski SC, Schreier PH, Pérez-Martín J, Richters A, Getlik M, Gutbrod O, Braun CA, Beck ME, Rauh D. Targeting GSK3 from Ustilago maydis: type-II kinase inhibitors as potential antifungals. Acs Chemical Biology. 7: 1257-67. PMID 22545924 DOI: 10.1021/Cb300128B  0.383
2012 Getlik M, Grütter C, Simard JR, Nguyen HD, Robubi A, Aust B, van Otterlo WA, Rauh D. Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α. European Journal of Medicinal Chemistry. 48: 1-15. PMID 22154891 DOI: 10.1016/J.Ejmech.2011.11.019  0.368
2012 Simard JR, Rauh D. Fluorescence labels in kinases: a high-throughput kinase binding assay for the identification of DFG-out binding ligands. Methods in Molecular Biology (Clifton, N.J.). 800: 95-117. PMID 21964785 DOI: 10.1007/978-1-61779-349-3_8  0.449
2011 Tückmantel S, Greul JN, Janning P, Brockmeyer A, Grütter C, Simard JR, Gutbrod O, Beck ME, Tietjen K, Rauh D, Schreier PH. Identification of Ustilago maydis Aurora kinase as a novel antifungal target. Acs Chemical Biology. 6: 926-33. PMID 21671622 DOI: 10.1021/Cb200112Y  0.36
2011 Rode HB, Sos ML, Grütter C, Heynck S, Simard JR, Rauh D. Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor. Bioorganic & Medicinal Chemistry. 19: 429-39. PMID 21130659 DOI: 10.1016/J.Bmc.2010.11.007  0.329
2010 Klüter S, Simard JR, Rode HB, Grütter C, Pawar V, Raaijmakers HC, Barf TA, Rabiller M, van Otterlo WA, Rauh D. Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance. Chembiochem : a European Journal of Chemical Biology. 11: 2557-66. PMID 21080395 DOI: 10.1002/Cbic.201000352  0.367
2010 Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. Journal of Lipid Research. 51: 914-22. PMID 20388923 DOI: 10.1194/jlr.M900251  0.645
2010 Rabiller M, Getlik M, Klüter S, Richters A, Tückmantel S, Simard JR, Rauh D. Proteus in the world of proteins: conformational changes in protein kinases. Archiv Der Pharmazie. 343: 193-206. PMID 20336692 DOI: 10.1002/Ardp.201000028  0.381
2010 Simard JR, Getlik M, Grütter C, Schneider R, Wulfert S, Rauh D. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. Journal of the American Chemical Society. 132: 4152-60. PMID 20201574 DOI: 10.1021/Ja908083E  0.466
2010 Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Displacement assay for the detection of stabilizers of inactive kinase conformations. Journal of Medicinal Chemistry. 53: 357-67. PMID 19928858 DOI: 10.1021/Jm901297E  0.42
2010 Klüter S, Simard JR, Rode HB, Grütter C, Pawar V, Raaijmakers HCA, Barf TA, Rabiller M, van Otterlo WAL, Rauh D. Inside Cover: Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance (ChemBioChem 18/2010) Chembiochem. 11: 2474-2474. DOI: 10.1002/Cbic.201090088  0.339
2009 Simard JR, Grütter C, Pawar V, Aust B, Wolf A, Rabiller M, Wulfert S, Robubi A, Klüter S, Ottmann C, Rauh D. High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha. Journal of the American Chemical Society. 131: 18478-88. PMID 19950957 DOI: 10.1021/ja907795q  0.31
2009 Pillai BK, Jasuja R, Simard JR, Hamilton JA. Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. The Journal of Biological Chemistry. 284: 33296-304. PMID 19801636 DOI: 10.1074/Jbc.M109.043737  0.586
2009 Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D. Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors. Journal of the American Chemical Society. 131: 13286-96. PMID 19572644 DOI: 10.1021/Ja902010P  0.468
2009 Getlik M, Grütter C, Simard JR, Klüter S, Rabiller M, Rode HB, Robubi A, Rauh D. Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc. Journal of Medicinal Chemistry. 52: 3915-26. PMID 19462975 DOI: 10.1021/Jm9002928  0.377
2009 Simard JR, Klüter S, Grütter C, Getlik M, Rabiller M, Rode HB, Rauh D. A new screening assay for allosteric inhibitors of cSrc. Nature Chemical Biology. 5: 394-6. PMID 19396179 DOI: 10.1038/Nchembio.162  0.437
2009 Simard JR, Getlik M, Klüter S, Grütter C, Rabiller M, Wulfert S, Ruddigkeit L, Pawar V, Rode HB, Rauh D. Fluorescent-tagged Kinases: A New Assay System For Detecting And Screening For Allosteric Kinase Inhibitors Biophysical Journal. 96: 597a-598a. DOI: 10.1016/J.Bpj.2008.12.3127  0.472
2008 Simard JR, Pillai BK, Hamilton JA. Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase. Biochemistry. 47: 9081-9. PMID 18693753 DOI: 10.1021/Bi800697Q  0.58
2008 Michalczyk A, Klüter S, Rode HB, Simard JR, Grütter C, Rabiller M, Rauh D. Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorganic & Medicinal Chemistry. 16: 3482-8. PMID 18316192 DOI: 10.1016/J.Bmc.2008.02.053  0.339
2008 Simard JR, Kamp F, Hamilton JA. Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes. Biophysical Journal. 94: 4493-503. PMID 18296488 DOI: 10.1529/Biophysj.107.121186  0.627
2007 Brunaldi K, Simard JR, Kamp F, Rewal C, Asawakarn T, O'Shea P, Hamilton JA. Fluorescence assays for measuring fatty acid binding and transport through membranes. Methods in Molecular Biology (Clifton, N.J.). 400: 237-55. PMID 17951738 DOI: 10.1007/978-1-59745-519-0_16  0.621
2007 Simard JR, Kamp F, Hamilton JA. Acrylodan-labeled intestinal fatty acid-binding protein to measure concentrations of unbound fatty acids. Methods in Molecular Biology (Clifton, N.J.). 400: 27-43. PMID 17951725 DOI: 10.1007/978-1-59745-519-0_3  0.582
2006 Simard JR, Zunszain PA, Hamilton JA, Curry S. Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. Journal of Molecular Biology. 361: 336-51. PMID 16844140 DOI: 10.1016/J.Jmb.2006.06.028  0.562
2006 Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 45: 2882-93. PMID 16503643 DOI: 10.1021/Bi051999B  0.597
2005 Simard JR, Zunszain PA, Ha CE, Yang JS, Bhagavan NV, Petitpas I, Curry S, Hamilton JA. Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 102: 17958-63. PMID 16330771 DOI: 10.1073/Pnas.0506440102  0.566
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