Jürgen Wess - Publications

Affiliations: 
NIDDK, National Institutes of Health 

105 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Meister J, Bone DBJ, Knudsen JR, Barella LF, Velenosi TJ, Akhmedov D, Lee RJ, Cohen AH, Gavrilova O, Cui Y, Karsenty G, Chen M, Weinstein LS, Kleinert M, Berdeaux R, ... ... Wess J, et al. Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells. Nature Communications. 13: 22. PMID 35013148 DOI: 10.1038/s41467-021-27540-w  0.324
2021 Wess J. In Vivo Metabolic Roles of G Proteins of the Gi Family Studied with Novel Mouse Models. Endocrinology. PMID 34871353 DOI: 10.1210/endocr/bqab245  0.355
2021 Liu L, Dattaroy D, Simpson KF, Barella LF, Cui Y, Xiong Y, Jin J, König GM, Kostenis E, Roman JC, Kaestner KH, Doliba NM, Wess J. α-cell Gq signaling is critical for maintaining euglycemia. Jci Insight. PMID 34752420 DOI: 10.1172/jci.insight.152852  0.325
2021 Meister J, Wang L, Pydi SP, Wess J. Chemogenetic approaches to identify metabolically important GPCR signaling pathways: therapeutic implications. Journal of Neurochemistry. PMID 33540469 DOI: 10.1111/jnc.15314  0.32
2020 Wang L, Zhu L, Meister J, Bone DBJ, Pydi SP, Rossi M, Wess J. Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs. Annual Review of Pharmacology and Toxicology. PMID 32746768 DOI: 10.1146/Annurev-Pharmtox-030220-121042  0.313
2018 Deckmann K, Rafiq A, Erdmann C, Illig C, Durschnabel M, Wess J, Weidner W, Bschleipfer T, Kummer W. Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201700582R. PMID 29401598 DOI: 10.1096/Fj.201700582R  0.315
2018 ZHU L, WESS J. A Positive Allosteric Modulator Enhances the Ability of Beta Cell M3 Muscarinic Receptors to Simulate Insulin Secretion In Vitro and In Vivo Diabetes. 67: 1767-P. DOI: 10.2337/Db18-1767-P  0.331
2016 Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J. A G Protein-Biased Designer G Protein-Coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-Dependent Signaling Pathways. The Journal of Biological Chemistry. PMID 26851281 DOI: 10.1074/Jbc.M115.702282  0.304
2015 Rossi M, Cui Z, Nakajima K, Hu J, Zhu L, Wess J. Virus-Mediated Expression of DREADDs for In Vivo Metabolic Studies. Methods in Molecular Biology (Clifton, N.J.). 1335: 205-21. PMID 26260603 DOI: 10.1007/978-1-4939-2914-6_14  0.32
2014 Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J. Muscarinic acetylcholine receptors: novel opportunities for drug development. Nature Reviews. Drug Discovery. 13: 549-60. PMID 24903776 DOI: 10.1038/Nrd4295  0.363
2014 Kruse AC, Hu J, Kobilka BK, Wess J. Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. Current Opinion in Pharmacology. 16: 24-30. PMID 24662799 DOI: 10.1016/J.Coph.2014.02.006  0.323
2014 Kistemaker LEM, Bos ST, Mudde WM, Hylkema MN, Hiemstra PS, Wess J, Meurs H, Kerstjens HAM, Gosens R. Muscarinic M3 receptors contribute to allergen-induced airway remodeling in mice American Journal of Respiratory Cell and Molecular Biology. 50: 690-698. PMID 24156289 DOI: 10.1165/rcmb.2013-0220OC  0.305
2014 Kruse AC, Li J, Hu J, Kobilka BK, Wess J. Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. Journal of Molecular Neuroscience : Mn. 53: 316-23. PMID 24068573 DOI: 10.1007/S12031-013-0127-0  0.352
2013 Kruse AC, Weiss DR, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK. Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Molecular Pharmacology. 84: 528-40. PMID 23887926 DOI: 10.1124/Mol.113.087551  0.342
2013 Li JH, Jain S, McMillin SM, Cui Y, Gautam D, Sakamoto W, Lu H, Jou W, McGuinness OP, Gavrilova O, Wess J. A novel experimental strategy to assess the metabolic effects of selective activation of a Gq- coupled receptor in hepatocytes in vivo Endocrinology. 154: 3539-3551. PMID 23861369 DOI: 10.1210/En.2012-2127  0.362
2013 Nakajima K, Jain S, de Azua IR, McMillin SM, Rossi M, Wess J. Minireview: Novel aspects of M3 muscarinic receptor signaling in pancreatic β-cells Molecular Endocrinology. 27: 1208-1216. PMID 23820900 DOI: 10.1210/Me.2013-1084  0.386
2013 Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology Trends in Pharmacological Sciences. 34: 385-392. PMID 23769625 DOI: 10.1016/J.Tips.2013.04.006  0.355
2013 Jain S, De Azua IR, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer Gq-coupled receptor improves β cell function Journal of Clinical Investigation. 123: 1750-1762. PMID 23478411 DOI: 10.1172/Jci66432  0.332
2012 Nakajima KI, Wess J. Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor Molecular Pharmacology. 82: 575-582. PMID 22821234 DOI: 10.1124/Mol.112.080358  0.33
2012 De Azua IR, Nakajima KI, Rossi M, Cui Y, Jou W, Gavrilova O, Wess J. Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo Faseb Journal. 26: 4275-4286. PMID 22730439 DOI: 10.1096/Fj.12-204644  0.337
2012 Ruiz De Azua I, Gautam D, Jain S, Guettier JM, Wess J. Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors Life Sciences. 91: 986-991. PMID 22525375 DOI: 10.1016/J.Lfs.2012.04.010  0.344
2012 Dencker D, Thomsen M, Wörtwein G, Weikop P, Cui Y, Jeon J, Wess J, Fink-Jensen A. Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease. Acs Chemical Neuroscience. 3: 80-89. PMID 22389751 DOI: 10.1021/Cn200110Q  0.722
2012 Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 482: 552-6. PMID 22358844 DOI: 10.1038/Nature10867  0.31
2012 Wess J. Novel muscarinic receptor mutant mouse models Handbook of Experimental Pharmacology. 208: 95-117. PMID 22222697 DOI: 10.1007/978-3-642-23274-9_6  0.324
2012 Guo JD, Hazra R, Dabrowska J, Muly EC, Wess J, Rainnie DG. Presynaptic muscarinic M(2) receptors modulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropharmacology. 62: 1671-83. PMID 22166222 DOI: 10.1016/J.Neuropharm.2011.11.013  0.313
2012 Veeraragavan S, Graham D, Bui N, Yuva-Paylor LA, Wess J, Paylor R. Genetic reduction of muscarinic M 4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS) Behavioural Brain Research. 228: 1-8. PMID 22123412 DOI: 10.1016/J.Bbr.2011.11.018  0.319
2012 Thomsen M, Lindsley CW, Conn PJ, Wessell JE, Fulton BS, Wess J, Caine SB. Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice Psychopharmacology. 220: 673-685. PMID 21964721 DOI: 10.1007/S00213-011-2516-9  0.687
2012 Dencker D, Thomsen M, Wörtwein G, Weikop P, Cui Y, Jeon J, Wess J, Fink-Jensen A. Muscarinic acetylcholine receptor subtypes as potential drug targets for the treatment of schizophrenia, drug abuse, and Parkinson's disease Acs Chemical Neuroscience. 3: 80-89. DOI: 10.1021/cn200110q  0.627
2011 Gericke A, Sniatecki JJ, Goloborodko E, Steege A, Zavaritskaya O, Vetter JM, Grus FH, Patzak A, Wess J, Pfeiffer N. Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arterioles Investigative Ophthalmology and Visual Science. 52: 7479-7484. PMID 21873683 DOI: 10.1167/Iovs.11-7370  0.36
2011 Dencker D, Wörtwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mørk A, Woldbye DPD, Wess J, Fink-Jensen A. Involvement of a subpopulation of neuronal M 4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M 1/M 4 preferring muscarinic receptor agonist xanomeline Journal of Neuroscience. 31: 5905-5908. PMID 21508215 DOI: 10.1523/Jneurosci.0370-11.2011  0.708
2011 Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DPD, Wortwein G, Fink-Jensen A. Increased cocaine self-administration in M 4 muscarinic acetylcholine receptor knockout mice Psychopharmacology. 216: 367-378. PMID 21373792 DOI: 10.1007/S00213-011-2225-4  0.665
2011 Gericke A, Sniatecki JJ, Mayer VGA, Goloborodko E, Patzak A, Wess J, Pfeiffer N. Role of m1, m3, and m5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice American Journal of Physiology - Heart and Circulatory Physiology. 300: H1602-H1608. PMID 21335473 DOI: 10.1152/ajpheart.00982.2010  0.348
2011 Fink-Jensen A, Schmidt LS, Dencker D, Schülein C, Wess J, Wörtwein G, Woldbye DPD. Antipsychotic-induced catalepsy is attenuated in mice lacking the M 4 muscarinic acetylcholine receptor European Journal of Pharmacology. 656: 39-44. PMID 21269601 DOI: 10.1016/J.Ejphar.2011.01.018  0.319
2011 Azua IRd, Gautam D, Guettier JM, Wess J. Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: Therapeutic implications Trends in Endocrinology and Metabolism. 22: 74-80. PMID 21106385 DOI: 10.1016/J.Tem.2010.10.004  0.348
2010 Kong KC, Butcher AJ, McWilliams P, Jones D, Wess J, Hamdan FF, Werry T, Rosethorne EM, Charlton SJ, Munson SE, Cragg HA, Smart AD, Tobin AB. M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1 Proceedings of the National Academy of Sciences of the United States of America. 107: 21181-21186. PMID 21078968 DOI: 10.1073/Pnas.1011651107  0.346
2010 Hu J, Wang Y, Zhang X, Lloyd JR, Li JH, Karpiak J, Costanzi S, Wess J. Structural basis of G protein-coupled receptor-G protein interactions. Nature Chemical Biology. 6: 541-8. PMID 20512139 DOI: 10.1038/Nchembio.385  0.309
2010 Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J, Rosethorne EM, Charlton SJ, Tobin AB. The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 107: 9440-5. PMID 20439723 DOI: 10.1073/Pnas.0914801107  0.34
2010 Jeon J, Dencker D, Wörtwein G, Woldbye DP, Cui Y, Davis AA, Levey AI, Schütz G, Sager TN, Mørk A, Li C, Deng CX, Fink-Jensen A, Wess J. A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2396-405. PMID 20147565 DOI: 10.1523/Jneurosci.3843-09.2010  0.302
2010 Balasubramanian R, Ruiz de Azua I, Wess J, Jacobson KA. Activation of distinct P2Y receptor subtypes stimulates insulin secretion in MIN6 mouse pancreatic beta cells. Biochemical Pharmacology. 79: 1317-26. PMID 20067775 DOI: 10.1016/J.Bcp.2009.12.026  0.306
2010 Thomsen M, Wess J, Fulton BS, Fink-Jensen A, Caine SB. Modulation of prepulse inhibition through both M1 and M 4 muscarinic receptors in mice Psychopharmacology. 208: 401-416. PMID 20013114 DOI: 10.1007/S00213-009-1740-Z  0.659
2010 Thomsen M, Conn PJ, Lindsley C, Wess J, Boon JY, Fulton BS, Fink-Jensen A, Caine SB. Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation Journal of Pharmacology and Experimental Therapeutics. 332: 959-969. PMID 19996296 DOI: 10.1124/Jpet.109.162057  0.668
2009 Pooput C, Rosemond E, Karpiak J, Deflorian F, Vilar S, Costanzi S, Wess J, Kirk KL. Structural basis of the selectivity of the β2-adrenergic receptor for fluorinated catecholamines Bioorganic and Medicinal Chemistry. 17: 7987-7992. PMID 19857969 DOI: 10.1016/J.Bmc.2009.10.015  0.328
2009 Li JH, Chou CL, Li B, Gavrilova O, Eisner C, Schnermann J, Anderson SA, Deng CX, Knepper MA, Wess J. A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. The Journal of Clinical Investigation. 119: 3115-26. PMID 19729836 DOI: 10.1172/Jci39680  0.323
2009 Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, Yamada M, Wess J. M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 330: 487-93. PMID 19429792 DOI: 10.1124/Jpet.109.153304  0.347
2009 Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proceedings of the National Academy of Sciences of the United States of America. 106: 6398-403. PMID 19332789 DOI: 10.1073/Pnas.0900977106  0.314
2009 Klein MK, Haberberger RV, Hartmann P, Faulhammer P, Lips KS, Krain B, Wess J, Kummer W, König P. Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. The European Respiratory Journal. 33: 1113-21. PMID 19213795 DOI: 10.1183/09031936.00015108  0.313
2008 Wess J, Han SJ, Kim SK, Jacobson KA, Li JH. Conformational changes involved in G-protein-coupled-receptor activation. Trends in Pharmacological Sciences. 29: 616-25. PMID 18838178 DOI: 10.1016/J.Tips.2008.08.006  0.302
2008 Gautam D, Jeon J, Li JH, Han SJ, Hamdan FF, Cui Y, Lu H, Deng C, Gavrilova O, Wess J. Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review. Journal of Receptor and Signal Transduction Research. 28: 93-108. PMID 18437633 DOI: 10.1080/10799890801942002  0.36
2008 Li JH, Hamdan FF, Kim SK, Jacobson KA, Zhang X, Han SJ, Wess J. Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy. Biochemistry. 47: 2776-88. PMID 18247581 DOI: 10.1021/Bi7019113  0.338
2008 Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unno T, Komori S, Yamada M, Wess J, Taneike T. Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 503-13. PMID 18071676 DOI: 10.1007/S00210-007-0223-1  0.361
2008 Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature Chemical Biology. 4: 42-50. PMID 18059262 DOI: 10.1038/Nchembio.2007.55  0.319
2007 Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nature Reviews. Drug Discovery. 6: 721-33. PMID 17762886 DOI: 10.1038/Nrd2379  0.324
2007 Li JH, Han SJ, Hamdan FF, Kim SK, Jacobson KA, Bloodworth LM, Zhang X, Wess J. Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands. The Journal of Biological Chemistry. 282: 26284-93. PMID 17623649 DOI: 10.1074/Jbc.M704875200  0.334
2007 Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB. Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology. 192: 97-110. PMID 17310388 DOI: 10.1007/S00213-006-0682-Y  0.717
2006 Gautam D, Duttaroy A, Cui Y, Han SJ, Deng C, Seeger T, Alzheimer C, Wess J. M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes. Journal of Molecular Neuroscience : Mn. 30: 157-60. PMID 17192665 DOI: 10.1385/Jmn:30:1:157  0.347
2006 Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J. Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metabolism. 4: 363-75. PMID 17084710 DOI: 10.1016/J.Cmet.2006.09.008  0.335
2006 Ward SD, Hamdan FF, Bloodworth LM, Siddiqui NA, Li JH, Wess J. Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor. Biochemistry. 45: 676-85. PMID 16411743 DOI: 10.1021/Bi051503Q  0.31
2005 Thomsen M, Woldbye DP, Wörtwein G, Fink-Jensen A, Wess J, Caine SB. Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8141-9. PMID 16148222 DOI: 10.1523/Jneurosci.2077-05.2005  0.649
2005 Han SJ, Hamdan FF, Kim SK, Jacobson KA, Bloodworth LM, Li B, Wess J. Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 280: 34849-58. PMID 16093246 DOI: 10.1074/Jbc.M506711200  0.316
2005 Zimring JC, Kapp LM, Yamada M, Wess J, Kapp JA. Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway. Journal of Neuroimmunology. 164: 66-75. PMID 15913791 DOI: 10.1016/J.Jneuroim.2005.03.018  0.359
2005 Han SJ, Hamdan FF, Kim SK, Jacobson KA, Brichta L, Bloodworth LM, Li JH, Wess J. Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 280: 24870-9. PMID 15870064 DOI: 10.1074/Jbc.M500379200  0.332
2005 Gautam D, Han SJ, Heard TS, Cui Y, Miller G, Bloodworth L, Wess J. Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. The Journal of Pharmacology and Experimental Therapeutics. 313: 995-1002. PMID 15764735 DOI: 10.1124/Jpet.105.084855  0.347
2005 Li B, Nowak NM, Kim SK, Jacobson KA, Bagheri A, Schmidt C, Wess J. Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor. The Journal of Biological Chemistry. 280: 5664-75. PMID 15572356 DOI: 10.1074/Jbc.M411623200  0.345
2004 Gautam D, Heard TS, Cui Y, Miller G, Bloodworth L, Wess J. Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice. Molecular Pharmacology. 66: 260-7. PMID 15266016 DOI: 10.1124/Mol.66.2.260  0.35
2004 Khurana S, Chacon I, Xie G, Yamada M, Wess J, Raufman JP, Kennedy RH. Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice. European Journal of Pharmacology. 493: 127-32. PMID 15189773 DOI: 10.1016/J.Ejphar.2004.04.012  0.304
2004 Sangkuhl K, Schulz A, Römpler H, Yun J, Wess J, Schöneberg T. Aminoglycoside-mediated rescue of a disease-causing nonsense mutation in the V2 vasopressin receptor gene in vitro and in vivo. Human Molecular Genetics. 13: 893-903. PMID 14998935 DOI: 10.1093/Hmg/Ddh105  0.325
2003 Struckmann N, Schwering S, Wiegand S, Gschnell A, Yamada M, Kummer W, Wess J, Haberberger RV. Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Molecular Pharmacology. 64: 1444-1451. PMID 14645675 DOI: 10.1124/Mol.64.6.1444  0.306
2003 Yamada M, Basile AS, Fedorova I, Zhang W, Duttaroy A, Cui Y, Lamping KG, Faraci FM, Deng CX, Wess J. Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology. Life Sciences. 74: 345-53. PMID 14607263 DOI: 10.1016/J.Lfs.2003.09.022  0.365
2003 Fink-Jensen A, Fedorova I, Wörtwein G, Woldbye DP, Rasmussen T, Thomsen M, Bolwig TG, Knitowski KM, McKinzie DL, Yamada M, Wess J, Basile A. Role for M5 muscarinic acetylcholine receptors in cocaine addiction. Journal of Neuroscience Research. 74: 91-6. PMID 13130510 DOI: 10.1002/Jnr.10728  0.673
2003 Bymaster FP, Carter PA, Yamada M, Gomeza J, Wess J, Hamilton SE, Nathanson NM, McKinzie DL, Felder CC. Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. The European Journal of Neuroscience. 17: 1403-10. PMID 12713643 DOI: 10.1046/J.1460-9568.2003.02588.X  0.319
2003 Wess J, Duttaroy A, Gomeza J, Zhang W, Yamada M, Felder CC, Bernardini N, Reeh PW. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: A review Life Sciences. 72: 2047-2054. PMID 12628455 DOI: 10.1016/S0024-3205(03)00082-1  0.399
2003 Trendelenburg AU, Gomeza J, Klebroff W, Zhou H, Wess J. Heterogeneity of presynaptic muscarinic receptors mediating inhibition of sympathetic transmitter release: a study with M2- and M4-receptor-deficient mice. British Journal of Pharmacology. 138: 469-80. PMID 12569072 DOI: 10.1038/Sj.Bjp.0705053  0.342
2002 Duttaroy A, Gomeza J, Gan JW, Siddiqui N, Basile AS, Harman WD, Smith PL, Felder CC, Levey AI, Wess J. Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Molecular Pharmacology. 62: 1084-93. PMID 12391271 DOI: 10.1124/Mol.62.5.1084  0.372
2002 Hemrick-Luecke SK, Bymaster FP, Evans DC, Wess J, Felder CC. Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 303: 99-103. PMID 12235238 DOI: 10.1124/Jpet.102.036020  0.322
2002 Zhang W, Yamada M, Gomeza J, Basile AS, Wess J. Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6347-52. PMID 12151512 DOI: 10.1523/Jneurosci.22-15-06347.2002  0.32
2002 Porter AC, Bymaster FP, DeLapp NW, Yamada M, Wess J, Hamilton SE, Nathanson NM, Felder CC. M1 muscarinic receptor signaling in mouse hippocampus and cortex. Brain Research. 944: 82-9. PMID 12106668 DOI: 10.1016/S0006-8993(02)02721-X  0.348
2002 Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J. Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1709-17. PMID 11880500 DOI: 10.1523/Jneurosci.22-05-01709.2002  0.334
2002 Ward SD, Hamdan FF, Bloodworth LM, Wess J. Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy. The Journal of Biological Chemistry. 277: 2247-57. PMID 11698401 DOI: 10.1074/Jbc.M107647200  0.319
2002 Wess J. Considerations in the design and use of chimeric G protein-coupled receptors. Methods in Enzymology. 343: 295-312. PMID 11665575 DOI: 10.1016/S0076-6879(02)43143-6  0.348
2002 Zeng F, Soldner A, Schöneberg T, Wess J. Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling Journal of Neurochemistry. 72: 2404-2414. PMID 10349850 DOI: 10.1046/J.1471-4159.1999.0722404.X  0.349
2001 Yamada M, Lamping KG, Duttaroy A, Zhang W, Cui Y, Bymaster FP, McKinzie DL, Felder CC, Deng CX, Faraci FM, Wess J. Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 14096-101. PMID 11707605 DOI: 10.1073/Pnas.251542998  0.36
2001 Felder CC, Porter AC, Skillman TL, Zhang L, Bymaster FP, Nathanson NM, Hamilton SE, Gomeza J, Wess J, McKinzie DL. Elucidating the role of muscarinic receptors in psychosis. Life Sciences. 68: 2605-13. PMID 11392633 DOI: 10.1016/S0024-3205(01)01059-1  0.339
2001 Shapiro MS, Gomeza J, Hamilton SE, Hille B, Loose MD, Nathanson NM, Roche JP, Wess J. Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons. Life Sciences. 68: 2481-7. PMID 11392616 DOI: 10.1016/S0024-3205(01)01042-6  0.337
2001 Bymaster FP, Carter PA, Zhang L, Falcone JF, Stengel PW, Cohen ML, Shannon HE, Gomeza J, Wess J, Felder CC. Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice. Life Sciences. 68: 2473-9. PMID 11392615 DOI: 10.1016/S0024-3205(01)01041-4  0.332
2001 Gomeza J, Zhang L, Kostenis E, Felder CC, Bymaster FP, Brodkin J, Shannon H, Xia B, Duttaroy A, Deng Cx, Wess J. Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice Life Sciences. 68: 2457-2466. PMID 11392613 DOI: 10.1016/S0024-3205(01)01039-6  0.393
2001 Erlenbach I, Kostenis E, Schmidt C, Hamdan FF, Pausch MH, Wess J. Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast. Journal of Neurochemistry. 77: 1327-37. PMID 11389184 DOI: 10.1046/J.1471-4159.2001.00344.X  0.319
2001 Erlenbach I, Kostenis E, Schmidt C, Serradeil-Le Gal C, Raufaste D, Dumont ME, Pausch MH, Wess J. Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis. The Journal of Biological Chemistry. 276: 29382-92. PMID 11375990 DOI: 10.1074/Jbc.M103203200  0.335
2001 Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng CX, Wess J. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature. 410: 207-12. PMID 11242080 DOI: 10.1038/35065604  0.302
1999 Shapiro MS, Loose MD, Hamilton SE, Nathanson NM, Gomeza J, Wess J, Hille B. Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 10899-904. PMID 10485923 DOI: 10.1073/pnas.96.19.10899  0.312
1999 Zeng F, Wess J. Identification and Molecular Characterization of m3 Muscarinic Receptor Dimers Journal of Biological Chemistry. 274: 19487-19497. PMID 10383466 DOI: 10.1074/Jbc.274.27.19487  0.326
1999 Zeng F, Hopp A, Soldner A, Wess J. Use of a Disulfide Cross-linking Strategy to Study Muscarinic Receptor Structure and Mechanisms of Activation Journal of Biological Chemistry. 274: 16629-16640. PMID 10347230 DOI: 10.1074/Jbc.274.23.16629  0.32
1999 Kostenis E, Zeng F, Wess J. Structure-function analysis of muscarinic receptors and their associated G proteins Life Sciences. 64: 355-362. PMID 10069496 DOI: 10.1016/S0024-3205(98)00574-8  0.346
1999 Jakubik J, Wess J. Use Of A Sandwich Enzyme-Linked Immunosorbent Assay Strategy To Study Mechanisms Of G Protein-Coupled Receptor Assembly Journal of Biological Chemistry. 274: 1349-1358. PMID 9880506 DOI: 10.1074/Jbc.274.3.1349  0.328
1998 Schöneberg T, Kostenis E, Liu J, Gudermann T, Wess J. Molecular aspects of vasopressin receptor function Advances in Experimental Medicine and Biology. 449: 347-358. PMID 10026824 DOI: 10.1007/978-1-4615-4871-3_44  0.354
1998 Erlenbach I, Wess J. Molecular Basis of V2 Vasopressin Receptor/GsCoupling Selectivity Journal of Biological Chemistry. 273: 26549-26558. PMID 9756892 DOI: 10.1074/Jbc.273.41.26549  0.35
1998 Kostenis E, Zeng F, Wess J. Functional Characterization of a Series of Mutant G Protein αq Subunits Displaying Promiscuous Receptor Coupling Properties Journal of Biological Chemistry. 273: 17886-17892. PMID 9651394 DOI: 10.1074/Jbc.273.28.17886  0.307
1997 Schöneberg T, Sandig V, Wess J, Gudermann T, Schultz G. Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer: Molecular basis and clinical implication Journal of Clinical Investigation. 100: 1547-1556. PMID 9294123 DOI: 10.1172/Jci119678  0.33
1997 Wess J, Blin N, Yun J, Schöneberg T, Liu J. Molecular aspects of muscarinic receptor assembly and function. Progress in Brain Research. 109: 153-62. PMID 9009702 DOI: 10.1016/S0079-6123(08)62097-X  0.326
1996 Wenkert D, Schoneberg T, Merendino JJ, Rodriguez Pena MS, Vinitsky R, Goldsmith PK, Wess J, Spiegel AM. Functional characterization of five V2 vasopressin receptor gene mutations. Molecular and Cellular Endocrinology. 124: 43-50. PMID 9027323 DOI: 10.1016/S0303-7207(96)03926-3  0.303
1996 Liu J, Blin N, Conklin BR, Wess J. Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. The Journal of Biological Chemistry. 271: 6172-8. PMID 8626406 DOI: 10.1074/Jbc.271.11.6172  0.325
1996 Liu J, Wess J. Different Single Receptor Domains Determine the Distinct G Protein Coupling Profiles of Members of the Vasopressin Receptor Family Journal of Biological Chemistry. 271: 8772-8778. PMID 8621513 DOI: 10.1074/Jbc.271.15.8772  0.338
1996 Schoneberg T, Yun J, Wenkert D, Wess J. Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co‐expressed receptor polypeptide. The Embo Journal. 15: 1283-1291. DOI: 10.1002/J.1460-2075.1996.Tb00470.X  0.34
1995 Liu J, Conklin BR, Blin N, Yun J, Wess J. Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proceedings of the National Academy of Sciences of the United States of America. 92: 11642-6. PMID 8524820 DOI: 10.1073/Pnas.92.25.11642  0.328
1994 Bluml K, Mutschler E, Wess J. Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling Proceedings of the National Academy of Sciences of the United States of America. 91: 7980-7984. PMID 8058746 DOI: 10.1073/Pnas.91.17.7980  0.31
1993 Maggio R, Vogel Z, Wess J. Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors Proceedings of the National Academy of Sciences of the United States of America. 90: 3103-3107. PMID 8385357 DOI: 10.1073/Pnas.90.7.3103  0.324
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