Uffe Kristiansen - Publications

Medicinal Chemistry Research University of Copenhagen, København, Denmark 

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Falk-Petersen CB, Tsonkov TM, Nielsen MS, Harpsøe K, Bundgaard C, Frølund B, Kristiansen U, Gloriam DE, Wellendorph P. Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA receptors. Scientific Reports. 10: 10078. PMID 32572053 DOI: 10.1038/s41598-020-66821-0  0.48
2017 von Schoubye NL, Frederiksen K, Kristiansen U, Petersen AV, Dalby NO, Grunnet M, Jensen HS, Jespersen T, Sohal VS, Perrier JF. The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6(+/-) mice. Neuroscience Letters. PMID 28987817 DOI: 10.1016/j.neulet.2017.10.004  0.56
2017 Simonsen C, Boddum K, von Schoubye NL, Kloppenburg A, Sønderskov K, Hansen SL, Kristiansen U. Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells. Pharmacology Research & Perspectives. 5. PMID 28805971 DOI: 10.1002/prp2.322  0.56
2016 Boddum K, Jensen TP, Magloire V, Kristiansen U, Rusakov DA, Pavlov I, Walker MC. Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nature Communications. 7: 13572. PMID 27886179 DOI: 10.1038/ncomms13572  0.56
2016 Gasiorek A, Trattnig SM, Ahring PK, Kristiansen U, Frølund B, Frederiksen K, Jensen AA. Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology. 110: 92-108. PMID 27086281 DOI: 10.1016/j.bcp.2016.04.004  0.56
2015 Krall J, Balle T, Krogsgaard-Larsen N, Sørensen TE, Krogsgaard-Larsen P, Kristiansen U, Frølund B. GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology. Advances in Pharmacology (San Diego, Calif.). 72: 201-27. PMID 25600372 DOI: 10.1016/bs.apha.2014.10.003  0.48
2014 Boddum K, Frølund B, Kristiansen U. The GABAA antagonist DPP-4-PIOL selectively antagonises tonic over phasic GABAergic currents in dentate gyrus granule cells. Neurochemical Research. 39: 2078-84. PMID 25103229 DOI: 10.1007/s11064-014-1397-9  0.56
2014 Kjaerby C, Broberg BV, Kristiansen U, Dalby NO. Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats. Cerebral Cortex (New York, N.Y. : 1991). 24: 2522-32. PMID 23613110 DOI: 10.1093/cercor/bht109  0.56
2013 Kjaerby C, Bundgaard C, Fejgin K, Kristiansen U, Dalby NO. Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment. Neuropharmacology. 72: 157-68. PMID 23643744 DOI: 10.1016/j.neuropharm.2013.04.041  0.56
2013 Petersen JG, Bergmann R, Møller HA, Jørgensen CG, Nielsen B, Kehler J, Frydenvang K, Kristensen J, Balle T, Jensen AA, Kristiansen U, Frølund B. Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as γ-aminobutyric acid(a) receptor agonists. Journal of Medicinal Chemistry. 56: 993-1006. PMID 23294161 DOI: 10.1021/jm301473k  0.48
2012 Hansen SL, Sterjev Z, Werngreen M, Simonsen BJ, Knudsen KE, Nielsen AH, Pedersen ME, Badolo L, Kristiansen U, Vestergaard HT. Does brain slices from pentylenetetrazole-kindled mice provide a more predictive screening model for antiepileptic drugs? European Journal of Pharmacology. 682: 43-49. PMID 22366211 DOI: 10.1016/j.ejphar.2012.01.044  0.56
2009 Hansen SL, Nielsen AH, Knudsen KE, Artmann A, Petersen G, Kristiansen U, Hansen SH, Hansen HS. Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus Neurochemistry International. 54: 199-204. PMID 19100800 DOI: 10.1016/j.neuint.2008.10.012  0.56
2007 Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B. 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists. Journal of Medicinal Chemistry. 50: 4147-61. PMID 17655213 DOI: 10.1021/jm070447j  0.48
2007 Vestergaard HT, Cannillo C, Frølund B, Kristiansen U. Differences in kinetics of structurally related competitive GABA(A) receptor antagonists. Neuropharmacology. 52: 873-82. PMID 17125806 DOI: 10.1016/j.neuropharm.2006.10.004  0.48
2006 Lolli ML, Hansen SL, Rolando B, Nielsen B, Wellendorph P, Madsen K, Larsen OM, Kristiansen U, Fruttero R, Gasco A, Johansen TN. Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of γ-aminobutyric acid (GABA) related compounds Journal of Medicinal Chemistry. 49: 4442-4446. PMID 16821803 DOI: 10.1021/jm051288b  0.56
2005 Frølund B, Jensen LS, Guandalini L, Canillo C, Vestergaard HT, Kristiansen U, Nielsen B, Stensbøl TB, Madsen C, Krogsgaard-Larsen P, Liljefors T. Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. Journal of Medicinal Chemistry. 48: 427-39. PMID 15658856 DOI: 10.1021/jm049256w  0.48
2004 Mortensen M, Kristiansen U, Ebert B, Frølund B, Krogsgaard-Larsen P, Smart TG. Activation of single heteromeric GABA(A) receptor ion channels by full and partial agonists. The Journal of Physiology. 557: 389-413. PMID 14990676 DOI: 10.1113/jphysiol.2003.054734  0.48
2003 Frølund B, Tagmose L, Jørgensen AT, Kristiansen U, Stensbøl TB, Liljefors T, Krogsgaard-Larsen P. Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABA A antagonists. European Journal of Medicinal Chemistry. 38: 447-9. PMID 12750034  0.48
2002 Frølund B, Ebert B, Kristiansen U, Liljefors T, Krogsgaard-Larsen P. GABA(A) receptor ligands and their therapeutic potentials. Current Topics in Medicinal Chemistry. 2: 817-32. PMID 12171573  0.48
2002 Frølund B, Jørgensen AT, Tagmose L, Stensbøl TB, Vestergaard HT, Engblom C, Kristiansen U, Sanchez C, Krogsgaard-Larsen P, Liljefors T. Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. Journal of Medicinal Chemistry. 45: 2454-68. PMID 12036354  0.48
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