Bart O Williams - Publications

Van Andel Research Institute, Grand Rapids, Michigan 
Wnt signaling, Skeletal Disease, Cancer Biology

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mirabelli CK, Nusse R, Tuveson DA, Williams BO. Perspectives on the role of Wnt biology in cancer. Science Signaling. 12. PMID 31289213 DOI: 10.1126/scisignal.aay4494  0.64
2016 Burgers TA, Vivanco JF, Zahatnansky J, Moren AJ, Mason JJ, Williams BO. Mice with a heterozygous Lrp6 deletion have impaired fracture healing. Bone Research. 4: 16025. PMID 27635281 DOI: 10.1038/boneres.2016.25  0.96
2016 Schumacher CA, Joiner DM, Less KD, Drewry MO, Williams BO. Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6. Bone Research. 4: 15042. PMID 26962465 DOI: 10.1038/boneres.2015.42  0.96
2016 Williams BO. Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 172: 24-26. DOI: 10.1002/ajmg.c.31474  0.96
2015 Zhong ZA, Peck A, Li S, VanOss J, Snider J, Droscha CJ, Chang TA, Williams BO. (99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice. Bone Research. 3: 15013. PMID 26273540 DOI: 10.1038/boneres.2015.13  0.96
2015 Zhong ZA, Zahatnansky J, Snider J, Van Wieren E, Diegel CR, Williams BO. Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 244: 1347-55. PMID 26249818 DOI: 10.1002/dvdy.24316  0.96
2015 Valkenburg KC, Hostetter G, Williams BO. Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice Prostate. 75: 1579-1585. PMID 26139199 DOI: 10.1002/pros.23032  0.96
2015 Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA. Vascular Smooth Muscle LRP6 Limits Arteriosclerotic Calcification in Diabetic LDLR-/- Mice by Restraining Noncanonical Wnt Signals. Circulation Research. PMID 26034040 DOI: 10.1161/CIRCRESAHA.117.306712  0.96
2015 Qin L, Yin YT, Zheng FJ, Peng LX, Yang CF, Bao YN, Liang YY, Li XJ, Xiang YQ, Sun R, Li AH, Zou RH, Pei XQ, Huang BJ, Kang TB, ... ... Williams BO, et al. WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis. Oncotarget. 6: 10239-52. PMID 25823923 DOI: 10.18632/ONCOTARGET.3518  0.96
2015 Peacock JD, Dykema KJ, Toriello HV, Mooney MR, Scholten DJ, Winn ME, Borgman A, Duesbery NS, Hiemenga JA, Liu C, Campbell S, Nickoloff BP, Williams BO, Steensma M. Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. American Journal of Medical Genetics. Part A. 167: 1429-35. PMID 25808193 DOI: 10.1002/ajmg.a.37048  0.96
2015 Collins CJ, Vivanco JF, Sokn SA, Williams BO, Burgers TA, Ploeg HL. Fracture healing in mice lacking Pten in osteoblasts: a micro-computed tomography image-based analysis of the mechanical properties of the femur. Journal of Biomechanics. 48: 310-7. PMID 25498366 DOI: 10.1016/j.jbiomech.2014.11.028  0.96
2015 Rudnicki MA, Williams BO. Wnt signaling in bone and muscle Bone. 80: 60-66. DOI: 10.1016/j.bone.2015.02.009  0.96
2014 Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Powell DR, He X, Bader M, Williams BO, Warman ML, Robling AG. Reply to Lrp5 regulation of bone mass and gut serotonin synthesis. Nature Medicine. 20: 1229-30. PMID 25375917 DOI: 10.1038/nm.3697  0.96
2014 Scholten DJ, Timmer CM, Peacock JD, Pelle DW, Williams BO, Steensma MR. Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells. Plos One. 9: e111431. PMID 25347326 DOI: 10.1371/journal.pone.0111431  0.96
2014 Zhong Z, Ethen NJ, Williams BO. WNT signaling in bone development and homeostasis. Wiley Interdisciplinary Reviews. Developmental Biology. 3: 489-500. PMID 25270716 DOI: 10.1002/wdev.159  0.96
2014 Valkenburg KC, Yu X, De Marzo AM, Spiering TJ, Matusik RJ, Williams BO. Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia. The Prostate. 74: 1506-20. PMID 25175604 DOI: 10.1002/pros.22868  0.96
2014 Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, Edison, Aliyev J, Wu Y, Bunte R, Williams BO, Rossant J, Virshup DM. Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. Development (Cambridge, England). 141: 2206-15. PMID 24821987 DOI: 10.1242/dev.104976  0.96
2014 Yang J, Mowry LE, Nejak-Bowen KN, Okabe H, Diegel CR, Lang RA, Williams BO, Monga SP. β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology (Baltimore, Md.). 60: 964-76. PMID 24700412 DOI: 10.1002/hep.27082  0.96
2014 Hoffmann MF, Burgers TA, Mason JJ, Williams BO, Sietsema DL, Jones CB. Biomechanical evaluation of fracture fixation constructs using a variable-angle locked periprosthetic femur plate system. Injury. 45: 1035-41. PMID 24680467 DOI: 10.1016/j.injury.2014.02.038  0.96
2014 Joiner DM, Less KD, Van Wieren EM, Zhang YW, Hess D, Williams BO. Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury. Arthritis Research & Therapy. 16: R81. PMID 24670222 DOI: 10.1186/ar4522  0.96
2014 Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW. Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. 111: 2590-5. PMID 24550287 DOI: 10.1073/pnas.1400744111  0.96
2014 Williams BO. Insights into the mechanisms of sclerostin action in regulating bone mass accrual. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 24-8. PMID 24285419 DOI: 10.1002/jbmr.2154  0.96
2014 Lim WH, Liu B, Cheng D, Hunter DJ, Zhong Z, Ramos DM, Williams BO, Sharpe PT, Bardet C, Mah SJ, Helms JA. Wnt signaling regulates pulp volume and dentin thickness. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 29: 892-901. PMID 23996396 DOI: 10.1002/jbmr.2088  0.96
2013 Ke J, Harikumar KG, Erice C, Chen C, Gu X, Wang L, Parker N, Cheng Z, Xu W, Williams BO, Melcher K, Miller LJ, Xu HE. Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes & Development. 27: 2305-19. PMID 24186977 DOI: 10.1101/gad.228544.113  0.96
2013 Hu B, Chen Y, Usmani SZ, Ye S, Qiang W, Papanikolaou X, Heuck CJ, Yaccoby S, Williams BO, Van Rhee F, Barlogie B, Epstein J, Qiang YW. Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma. Plos One. 8: e74191. PMID 24066119 DOI: 10.1371/journal.pone.0074191  0.96
2013 Steensma MR, Tyler WK, Shaber AG, Goldring SR, Ross FP, Williams BO, Healey JH, Purdue PE. Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy. Plos One. 8: e69101. PMID 23922683 DOI: 10.1371/journal.pone.0069101  0.96
2013 Loftus JC, Dhruv H, Tuncali S, Kloss J, Yang Z, Schumacher CA, Cao B, Williams BO, Eschbacher JM, Ross JT, Tran NL. TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance. Molecular Cancer Research : McR. 11: 865-74. PMID 23699535 DOI: 10.1158/1541-7786.MCR-13-0008  0.96
2013 Burgers TA, Hoffmann MF, Collins CJ, Zahatnansky J, Alvarado MA, Morris MR, Sietsema DL, Mason JJ, Jones CB, Ploeg HL, Williams BO. Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing. Plos One. 8: e63857. PMID 23675511 DOI: 10.1371/journal.pone.0063857  0.96
2013 Riddle RC, Diegel CR, Leslie JM, Van Koevering KK, Faugere MC, Clemens TL, Williams BO. Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. Plos One. 8: e63323. PMID 23675479 DOI: 10.1371/journal.pone.0063323  0.96
2013 Burgers TA, Williams BO. Regulation of Wnt/β-catenin signaling within and from osteocytes. Bone. 54: 244-9. PMID 23470835 DOI: 10.1016/j.bone.2013.02.022  0.96
2013 Valkenburg KC, Steensma MR, Williams BO, Zhong Z. Skeletal metastasis: Treatments, mouse models, and the Wnt signaling Chinese Journal of Cancer. 32: 380-396. PMID 23327798 DOI: 10.5732/cjc.012.10218  0.96
2013 Joiner DM, Ke J, Zhong Z, Xu HE, Williams BO. LRP5 and LRP6 in development and disease. Trends in Endocrinology and Metabolism: Tem. 24: 31-9. PMID 23245947 DOI: 10.1016/j.tem.2012.10.003  0.96
2012 Regard JB, Zhong Z, Williams BO, Yang Y. Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209148 DOI: 10.1101/cshperspect.a007997  0.96
2012 Zhong Z, Williams BO. Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass Journal of Bone and Mineral Research. 27: 1849-1851. PMID 22903578 DOI: 10.1002/jbmr.1715  0.96
2012 Zhong Z, Zylstra-Diegel CR, Schumacher CA, Baker JJ, Carpenter AC, Rao S, Yao W, Guan M, Helms JA, Lane NE, Lang RA, Williams BO. Wntless functions in mature osteoblasts to regulate bone mass. Proceedings of the National Academy of Sciences of the United States of America. 109: E2197-204. PMID 22745162 DOI: 10.1073/pnas.1120407109  0.96
2012 Fortin SP, Ennis MJ, Schumacher CA, Zylstra-Diegel CR, Williams BO, Ross JT, Winkles JA, Loftus JC, Symons MH, Tran NL. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Molecular Cancer Research : McR. 10: 958-68. PMID 22571869 DOI: 10.1158/1541-7786.MCR-11-0616  0.96
2012 Ke J, Zhang C, Harikumar KG, Zylstra-Diegel CR, Wang L, Mowry LE, Miller LJ, Williams BO, Xu HE. Modulation of β-catenin signaling by glucagon receptor activation. Plos One. 7: e33676. PMID 22438981 DOI: 10.1371/journal.pone.0033676  0.96
2012 Zhong Z, Baker JJ, Zylstra-Diegel CR, Williams BO. Lrp5 and Lrp6 play compensatory roles in mouse intestinal development. Journal of Cellular Biochemistry. 113: 31-8. PMID 21866564 DOI: 10.1002/jcb.23324  0.96
2012 Li Y, Ferris A, Lewis BC, Orsulic S, Williams BO, Holland EC, Hughes SH. The RCAS/TVA somatic gene transfer method in modeling human cancer Genetically Engineered Mice For Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing. 83-111. DOI: 10.1007/978-0-387-69805-2_5  0.96
2011 Valkenburg KC, Graveel CR, Zylstra-Diegel CR, Zhong Z, Williams BO. Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers. 3: 2050-79. PMID 24212796 DOI: 10.3390/cancers3022050  0.96
2011 Joeng KS, Schumacher CA, Zylstra-Diegel CR, Long F, Williams BO. Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Developmental Biology. 359: 222-9. PMID 21924256 DOI: 10.1016/j.ydbio.2011.08.020  0.96
2011 Stefater JA, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, et al. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 474: 511-5. PMID 21623369 DOI: 10.1038/nature10085  0.96
2011 Cui Y, Niziolek PJ, MacDonald BT, Zylstra CR, Alenina N, Robinson DR, Zhong Z, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Liu Q, Mseeh F, Powell DR, Yang QM, ... ... Williams BO, et al. Lrp5 functions in bone to regulate bone mass. Nature Medicine. 17: 684-91. PMID 21602802 DOI: 10.1038/nm.2388  0.96
2011 Wan M, Li J, Herbst K, Zhang J, Yu B, Wu X, Qiu T, Lei W, Lindvall C, Williams BO, Ma H, Zhang F, Cao X. LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s). Science Signaling. 4: ra15. PMID 21406690 DOI: 10.1126/scisignal.2001464  0.96
2010 Coulibaly MO, Sietsema DL, Burgers TA, Mason J, Williams BO, Jones CB. Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing. Critical Reviews in Eukaryotic Gene Expression. 20: 105-27. PMID 21133841  0.96
2010 Diegel CR, Cho KR, El-Naggar AK, Williams BO, Lindvall C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: Implications for human acinic cell carcinoma Cancer Research. 70: 9143-9152. PMID 21062985 DOI: 10.1158/0008-5472.CAN-10-1758  0.96
2009 Qian CN, Furge KA, Knol J, Huang D, Chen J, Dykema KJ, Kort EJ, Massie A, Khoo SK, Vanden Beldt K, Resau JH, Anema J, Kahnoski RJ, Morreau H, Camparo P, ... ... Williams BO, et al. Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models. Cancer Research. 69: 8256-64. PMID 19843858 DOI: 10.1158/0008-5472.CAN-09-1689  0.96
2009 Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 5: 279-89. PMID 19733540 DOI: 10.1016/j.stem.2009.06.017  0.96
2009 Badders NM, Goel S, Clark RJ, Klos KS, Kim S, Bafico A, Lindvall C, Williams BO, Alexander CM. The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. Plos One. 4: e6594. PMID 19672307 DOI: 10.1371/journal.pone.0006594  0.96
2009 Lindvall C, Zylstra CR, Evans N, West RA, Dykema K, Furge KA, Williams BO. The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. Plos One. 4: e5813. PMID 19503830 DOI: 10.1371/journal.pone.0005813  0.96
2009 Williams BO, Insogna KL. Where Wnts went: The exploding field of Lrp5 and Lrp6 signaling in bone Journal of Bone and Mineral Research. 24: 171-178. PMID 19072724 DOI: 10.1359/jbmr.081235  0.96
2008 Chen J, Futami K, Petillo D, Peng J, Wang P, Knol J, Li Y, Khoo SK, Huang D, Qian CN, Zhao P, Dykema K, Dykyma K, Zhang R, Cao B, ... ... Williams BO, et al. Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia. Plos One. 3: e3581. PMID 18974783 DOI: 10.1371/journal.pone.0003581  0.96
2008 Qian Z, Chen L, Fernald AA, Williams BO, Le Beau MM. A critical role for Apc in hematopoietic stem and progenitor cell survival. The Journal of Experimental Medicine. 205: 2163-75. PMID 18725524 DOI: 10.1084/jem.20080578  0.96
2008 Robinson DR, Zylstra CR, Williams BO. Wnt signaling and prostate cancer Current Drug Targets. 9: 571-580. PMID 18673243 DOI: 10.2174/138945008784911831  0.96
2008 Shekhar MP, Gerard B, Pauley RJ, Williams BO, Tait L. Rad6B is a positive regulator of beta-catenin stabilization. Cancer Research. 68: 1741-50. PMID 18339854 DOI: 10.1158/0008-5472.CAN-07-2111  0.96
2008 Wang P, Bowl MR, Bender S, Peng J, Farber L, Chen J, Ali A, Zhang Z, Alberts AS, Thakker RV, Shilatifard A, Williams BO, Teh BT. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Molecular and Cellular Biology. 28: 2930-40. PMID 18212049 DOI: 10.1128/MCB.00654-07  0.96
2008 Wolf J, Palmby TR, Gavard J, Williams BO, Gutkind JS. Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. Febs Letters. 582: 255-61. PMID 18083125 DOI: 10.1016/j.febslet.2007.12.013  0.96
2007 Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Research. 67: 9721-30. PMID 17942902 DOI: 10.1158/0008-5472.CAN-07-2735  0.96
2007 Lindvall C, Bu W, Williams BO, Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer Stem Cell Reviews. 3: 157-168. PMID 17873348 DOI: 10.1007/s12015-007-0025-3  0.96
2007 Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, Hanash S, Misek DE, Katabuchi H, Williams BO, Fearon ER, Cho KR. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell. 11: 321-33. PMID 17418409 DOI: 10.1016/j.ccr.2007.02.016  0.96
2007 Bruxvoort KJ, Charbonneau HM, Giambernardi TA, Goolsby JC, Qian CN, Zylstra CR, Robinson DR, Roy-Burman P, Shaw AK, Buckner-Berghuis BD, Sigler RE, Resau JH, Sullivan R, Bushman W, Williams BO. Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Research. 67: 2490-6. PMID 17363566 DOI: 10.1158/0008-5472.CAN-06-3028  0.96
2007 Young JJ, Bromberg-White JL, Zylstra C, Church JT, Boguslawski E, Resau JH, Williams BO, Duesbery NS. LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. Plos Pathogens. 3: e27. PMID 17335347 DOI: 10.1371/journal.ppat.0030027  0.96
2007 Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere MC, Bouxsein ML, Wan C, Williams BO, Clemens TL. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proceedings of the National Academy of Sciences of the United States of America. 104: 2259-64. PMID 17287359 DOI: 10.1073/pnas.0604153104  0.96
2006 Zhang C, Kong D, Tan MH, Pappas DL, Wang PF, Chen J, Farber L, Zhang N, Koo HM, Weinreich M, Williams BO, Teh BT. Parafibromin inhibits cancer cell growth and causes G1 phase arrest. Biochemical and Biophysical Research Communications. 350: 17-24. PMID 16989776 DOI: 10.1016/j.bbrc.2006.08.169  0.96
2006 Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. The Journal of Biological Chemistry. 281: 35081-7. PMID 16973609 DOI: 10.1074/jbc.M607571200  0.96
2006 Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 126: 955-68. PMID 16959574 DOI: 10.1016/j.cell.2006.06.055  0.96
2006 Park KS, Jeon SH, Kim SE, Bahk YY, Holmer SL, Williams BO, Chung KC, Surh YJ, Choi KY. APC inhibits ERK pathway activation and cellular proliferation induce by RAS Journal of Cell Science. 119: 819-827. PMID 16478791 DOI: 10.1242/jcs.02779  0.96
2005 Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Medicine: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis Science. 310: 1504-1510. PMID 16293724 DOI: 10.1126/science.1116221  0.96
2005 Holmen SL, Williams BO. Essential role for Ras signaling in glioblastoma maintenance Cancer Research. 65: 8250-8255. PMID 16166301 DOI: 10.1158/0008-5472.CAN-05-1173  0.96
2005 Ai M, Holmen SL, Van Hul W, Williams BO, Warman ML. Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Molecular and Cellular Biology. 25: 4946-55. PMID 15923613 DOI: 10.1128/MCB.25.12.4946-4955.2005  0.96
2005 Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. Essential role of beta-catenin in postnatal bone acquisition. The Journal of Biological Chemistry. 280: 21162-8. PMID 15802266 DOI: 10.1074/jbc.M501900200  0.96
2005 Robertson SA, Schoumans J, Looyenga BD, Yuhas JA, Zylstra CR, Koeman JM, Swiatek PJ, Teh BT, Williams BO. Spectral karyotyping of sarcomas and fibroblasts derived from Ink4a/Arf-deficient mice reveals chromosomal instability in vitro. International Journal of Oncology. 26: 629-34. PMID 15703817  0.96
2005 Holmen SL, Robertson SA, Zylstra CR, Williams BO. Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein Biochemical and Biophysical Research Communications. 328: 533-539. PMID 15694380 DOI: 10.1016/j.bbrc.2005.01.009  0.96
2005 Qian CN, Knol J, Igarashi P, Lin F, Zylstra U, Teh BT, Williams BO. Cystic renal neoplasia following conditional inactivation of Apc in mouse renal tubular epithelium Journal of Biological Chemistry. 280: 3938-3945. PMID 15550389 DOI: 10.1074/jbc.M410697200  0.96
2004 Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 2033-40. PMID 15537447 DOI: 10.1359/JBMR.040907  0.96
2004 Spike BT, Dirlam A, Dibling BC, Marvin J, Williams BO, Jacks T, Macleod KF. The Rb tumor suppressor is required for stress erythropoiesis. The Embo Journal. 23: 4319-29. PMID 15457215 DOI: 10.1038/sj.emboj.7600432  0.96
2004 Bromberg-White JL, Webb CP, Patacsil VS, Miranti CK, Williams BO, Holmen SL. Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector. Journal of Virology. 78: 4914-6. PMID 15078973 DOI: 10.1128/JVI.78.9.4914-4916.2004  0.96
2002 Takahashi M, Yang XJ, Lavery TT, Furge KA, Williams BO, Tretiakova M, Montag A, Vogelzang NJ, Re GG, Garvin AJ, Söderhäll S, Kagawa S, Hazel-Martin D, Nordenskjold A, Teh BT. Gene expression profiling of favorable histology Wilms tumors and its correlation with clinical features. Cancer Research. 62: 6598-605. PMID 12438255  0.96
2002 Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. The Journal of Biological Chemistry. 277: 34727-35. PMID 12121999 DOI: 10.1074/jbc.M204989200  0.96
2002 Yang H, Williams BO, Hinds PW, Shih TS, Jacks T, Bronson RT, Livingston DM. Tumor suppression by a severely truncated species of retinoblastoma protein Molecular and Cellular Biology. 22: 3103-3110. PMID 11940667 DOI: 10.1128/MCB.22.9.3103-3110.2002  0.96
2001 Lipinski MM, Macleod KF, Williams BO, Mullaney TL, Crowley D, Jacks T. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system Embo Journal. 20: 3402-3413. PMID 11432828 DOI: 10.1093/emboj/20.13.3402  0.96
2000 Williams BO, Barish GD, Klymkowsky MW, Varmus HE. A comparative evaluation of beta-catenin and plakoglobin signaling activity. Oncogene. 19: 5720-8. PMID 11126358 DOI: 10.1038/sj.onc.1203921  0.96
2000 Dunn KJ, Williams BO, Li Y, Pavan WJ. Neural crest-Directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development Proceedings of the National Academy of Sciences of the United States of America. 97: 10050-10055. PMID 10963668 DOI: 10.1073/PNAS.97.18.10050  0.96
1999 Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowsky MW, Varmus HE. Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Molecular Cell. 4: 487-98. PMID 10549281 DOI: 10.1016/S1097-2765(00)80200-2  0.96
1999 Klymkowsky MW, Williams BO, Barish GD, Varmus HE, Vourgourakis YE. Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Molecular Biology of the Cell. 10: 3151-69. PMID 10512857  0.96
1999 Fisher GH, Orsulic S, Holland E, Hively WP, Li Y, Lewis BC, Williams BO, Varmus HE. Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene. 18: 5253-60. PMID 10498877 DOI: 10.1038/sj.onc.1203087  0.96
1998 Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nature Genetics. 18: 360-4. PMID 9537419 DOI: 10.1038/ng0498-360  0.96
1996 Williams BO, Jacks T. Mechanisms of carcinogenesis and the mutant mouse Current Opinion in Genetics and Development. 6: 65-70. PMID 8791481 DOI: 10.1016/S0959-437X(96)90012-X  0.96
1996 Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes & Development. 10: 1621-32. PMID 8682293 DOI: 10.1101/gad.10.13.1621  0.96
1996 Herrera RE, Sah VP, Williams BO, Mäkelä TP, Weinberg RA, Jacks T. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts Molecular and Cellular Biology. 16: 2402-2407. PMID 8628308 DOI: 10.1128/MCB.16.5.2402  0.96
1995 Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of Pheochromocytomas in a Mouse Strain with a Targeted Disruptive Mutation of the Neurofibromatosis Gene Nf1. Endocrine Pathology. 6: 323-335. PMID 12114814  0.96
1995 Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, Jacks T. A subset of p53-deficient embryos exhibit exencephaly Nature Genetics. 10: 175-180. PMID 7663512 DOI: 10.1038/ng0695-175  0.96
1995 Tischler AS, Shih TS, Williams BO, Jacks T. Characterization of pheochromocytomas in a mouse strain with a targeted disruptive mutation of the neurofibromatosis gene Nf1 Endocrine Pathology. 6: 323-335. DOI: 10.1007/BF02738732  0.96
1994 Slebos RJC, Lee MH, Plunkett BS, Kessis TD, Williams BO, Jacks T, Hedrick L, Kastan MB, Cho KR. p53-Dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein Proceedings of the National Academy of Sciences of the United States of America. 91: 5320-5324. PMID 8202487 DOI: 10.1073/pnas.91.12.5320  0.96
1994 Morgenbesser SD, Williams BO, Jacks T, Depinho RA. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens Nature. 371: 72-74. PMID 8072529 DOI: 10.1038/371072a0  0.96
1994 Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T. Cooperative tumorigenic effects of germline mutations in Rb and p53 Nature Genetics. 7: 480-484. PMID 7951317 DOI: 10.1038/ng0894-480  0.96
1994 Williams BO, Schmitt EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences Embo Journal. 13: 4251-4259. PMID 7925270  0.96
1994 Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA. Tumor spectrum analysis in p53-mutant mice Current Biology. 4: 1-7. PMID 7922305 DOI: 10.1016/S0960-9822(00)00002-6  0.96
1994 Williams BO, Morgenbesser SD, DePinho RA, Jacks T. Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53 Cold Spring Harbor Symposia On Quantitative Biology. 59: 449-457. PMID 7587099 DOI: 10.1101/SQB.1994.059.01.050  0.96
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