William J. Griffiths - Publications

Affiliations: 
Swansea University, Sketty, Wales, United Kingdom 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Abdel-Khalik J, Hearn T, Dickson AL, Crick PJ, Yutuc E, Austin-Muttit K, Bigger BW, Morris AA, Shackleton CH, Clayton PT, Iida T, Sircar R, Rohatgi R, Marschall HU, Sjövall J, ... ... Griffiths WJ, et al. Bile Acid Biosynthesis in Smith-Lemli-Opitz Syndrome Bypassing Cholesterol: Potential Importance of Pathway Intermediates. The Journal of Steroid Biochemistry and Molecular Biology. 105794. PMID 33246156 DOI: 10.1016/j.jsbmb.2020.105794  0.32
2019 Meljon A, Crick PJ, Yutuc E, Yau JL, Seckl JR, Theofilopoulos S, Arenas E, Wang Y, Griffiths WJ. Mining for Oxysterols in Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules. 9. PMID 31013940 DOI: 10.3390/biom9040149  0.32
2019 Theofilopoulos S, Abreu de Oliveira WA, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, Ullgren A, Cedazo-Minguez A, Björkhem I, Wang Y, Griffiths WJ, Arenas E. 24(),25-Epoxycholesterol and () overexpression promote midbrain dopaminergic neurogenesis . The Journal of Biological Chemistry. PMID 30655290 DOI: 10.1074/Jbc.Ra118.005639  0.36
2018 Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30471425 DOI: 10.1016/J.Bbalip.2018.11.006  0.32
2016 Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, ... ... Griffiths WJ, et al. An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. Plos Biology. 14: e1002364. PMID 26938778 DOI: 10.1371/Journal.Pbio.1002364  0.32
2015 Iuliano L, Crick PJ, Zerbinati C, Tritapepe L, Abdel-Khalik J, Poirot M, Wang Y, Griffiths WJ. Cholesterol metabolites exported from human brain. Steroids. 99: 189-93. PMID 25668615 DOI: 10.1016/J.Steroids.2015.01.026  0.32
2014 Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, et al. Cholestenoic acids regulate motor neuron survival via liver X receptors. The Journal of Clinical Investigation. 124: 4829-42. PMID 25271621 DOI: 10.1172/Jci68506  0.32
2014 Wang Y, Karu K, Meljon A, Turton J, Yau JL, Seckl JR, Wang Y, Griffiths WJ. 24S,25-Epoxycholesterol in mouse and rat brain. Biochemical and Biophysical Research Communications. 449: 229-34. PMID 24832732 DOI: 10.1016/J.Bbrc.2014.05.012  0.32
2014 Autio KJ, Schmitz W, Nair RR, Selkälä EM, Sormunen RT, Miinalainen IJ, Crick PJ, Wang Y, Griffiths WJ, Reddy JK, Baes M, Hiltunen JK. Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice. The Biochemical Journal. 461: 125-35. PMID 24735479 DOI: 10.1042/Bj20130915  0.32
2013 Saini R, Kataeva O, Schmidt AW, Wang Y, Meljon A, Griffiths WJ, Knölker HJ. Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. Bioorganic & Medicinal Chemistry. 21: 5794-8. PMID 23910990 DOI: 10.1016/J.Bmc.2013.07.015  0.32
2013 Meljon A, Watson GL, Wang Y, Shackleton CH, Griffiths WJ. Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome. Biochemical Pharmacology. 86: 43-55. PMID 23500538 DOI: 10.1016/J.Bcp.2013.03.003  0.32
2013 Theofilopoulos S, Wang Y, Kitambi SS, Sacchetti P, Sousa KM, Bodin K, Kirk J, Saltó C, Gustafsson M, Toledo EM, Karu K, Gustafsson JÃ…, Steffensen KR, Ernfors P, Sjövall J, ... Griffiths WJ, et al. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology. 9: 126-33. PMID 23292650 DOI: 10.1038/Nchembio.1156  0.32
2013 Parker JE, Warrilow AG, Cools HJ, Fraaije BA, Lucas JA, Rigdova K, Griffiths WJ, Kelly DE, Kelly SL. Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase. Applied and Environmental Microbiology. 79: 1639-45. PMID 23275516 DOI: 10.1128/Aem.03246-12  0.32
2013 Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, ... ... Griffiths WJ, et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity. 38: 106-18. PMID 23273843 DOI: 10.1016/J.Immuni.2012.11.004  0.32
2013 Chen Y, Ogundare M, Williams CM, Wang Y, Wang Y, Sewell GW, Smith PJ, Rahman FZ, O'Shea N, Segal AW, Griffiths WJ. Shotgun cholanomics of ileal fluid. Biochimie. 95: 461-3. PMID 22986022 DOI: 10.1016/J.Biochi.2012.09.004  0.32
2012 Meljon A, Theofilopoulos S, Shackleton CH, Watson GL, Javitt NB, Knölker HJ, Saini R, Arenas E, Wang Y, Griffiths WJ. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. Journal of Lipid Research. 53: 2469-83. PMID 22891291 DOI: 10.1194/Jlr.D028233  0.32
2011 Rai DK, Brunton NP, Koidis A, Rawson A, McLoughlin P, Griffiths WJ. Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry Rapid Communications in Mass Spectrometry : Rcm. 25: 2231-2239. PMID 21735506 DOI: 10.1002/Rcm.5103  0.32
2011 Björkhem I, Diczfalusy U, Olsson T, Russell DW, McDonald JG, Wang Y, Griffiths WJ. Detecting oxysterols in the human circulation. Nature Immunology. 12: 577; author reply 57. PMID 21685947 DOI: 10.1038/Ni0711-577A  0.32
2011 Karu K, Turton J, Wang Y, Griffiths WJ. Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation. Chemistry and Physics of Lipids. 164: 411-24. PMID 21575613 DOI: 10.1016/J.Chemphyslip.2011.04.011  0.32
2010 Ogundare M, Theofilopoulos S, Lockhart A, Hall LJ, Arenas E, Sjövall J, Brenton AG, Wang Y, Griffiths WJ. Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain? The Journal of Biological Chemistry. 285: 4666-79. PMID 19996111 DOI: 10.1074/Jbc.M109.086678  0.32
2009 Liere P, Pianos A, Eychenne B, Cambourg A, Bodin K, Griffiths W, Schumacher M, Baulieu E, Sjövall J. Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: cholesterol autoxidation is the key Journal of Lipid Research. 50: 2430-2444. PMID 19506304 DOI: 10.1194/Jlr.M900162-Jlr200  0.32
2009 Alander J, Lengqvist J, Holm PJ, Svensson R, Gerbaux P, Heuvel RH, Hebert H, Griffiths WJ, Armstrong RN, Morgenstern R. Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione. Archives of Biochemistry and Biophysics. 487: 42-8. PMID 19416719 DOI: 10.1016/J.Abb.2009.04.009  0.32
2009 Wang Y, Sousa KM, Bodin K, Theofilopoulos S, Sacchetti P, Hornshaw M, Woffendin G, Karu K, Sjövall J, Arenas E, Griffiths WJ. Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular Biosystems. 5: 529-41. PMID 19381367 DOI: 10.1039/B819502A  0.32
2009 Smyth R, Lane CS, Ashiq R, Turton JA, Clarke CJ, Dare TO, York MJ, Griffiths W, Munday MR. Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat. Cell Biology and Toxicology. 25: 499-512. PMID 18777138 DOI: 10.1007/S10565-008-9104-8  0.32
2008 Claesson HE, Griffiths WJ, Brunnström A, Schain F, Andersson E, Feltenmark S, Johnson HA, Porwit A, Sjöberg J, Björkholm M. Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. The Febs Journal. 275: 4222-34. PMID 18647347 DOI: 10.1111/J.1742-4658.2008.06570.X  0.32
2008 Griffiths WJ, Hornshaw M, Woffendin G, Baker SF, Lockhart A, Heidelberger S, Gustafsson M, Sjövall J, Wang Y. Discovering oxysterols in plasma: a window on the metabolome. Journal of Proteome Research. 7: 3602-12. PMID 18605750 DOI: 10.1021/Pr8001639  0.32
2008 Griffiths WJ, Wang Y, Karu K, Samuel E, McDonnell S, Hornshaw M, Shackleton C. Potential of sterol analysis by liquid chromatography-tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome. Clinical Chemistry. 54: 1317-24. PMID 18556335 DOI: 10.1373/Clinchem.2007.100644  0.32
2008 Wang Y, Muneton S, Sjövall J, Jovanovic JN, Griffiths WJ. The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. Journal of Proteome Research. 7: 1606-14. PMID 18303831 DOI: 10.1021/Pr7006076  0.32
2008 Schumacher M, Liere P, Akwa Y, Rajkowski K, Griffiths W, Bodin K, Sjövall J, Baulieu E. Pregnenolone sulfate in the brain: a controversial neurosteroid. Neurochemistry International. 52: 522-540. PMID 18068870 DOI: 10.1016/J.Neuint.2007.08.022  0.32
2007 Lane CS, Wang Y, Betts R, Griffiths WJ, Patterson LH. Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling. Molecular & Cellular Proteomics : McP. 6: 953-62. PMID 17296599 DOI: 10.1074/Mcp.M600296-Mcp200  0.32
2007 Karu K, Hornshaw M, Woffendin G, Bodin K, Hamberg M, Alvelius G, Sjövall J, Turton J, Wang Y, Griffiths WJ. Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. Journal of Lipid Research. 48: 976-87. PMID 17251593 DOI: 10.1194/Jlr.M600497-Jlr200  0.32
2007 Wang Y, Karu K, Griffiths WJ. Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie. 89: 182-91. PMID 17126470 DOI: 10.1016/J.Biochi.2006.10.008  0.32
2006 Rai DK, Landin B, Alvelius G, Griffiths WJ. Haemoglobin Södertälje (β118 Phe→Val): A new mutation in human haemoglobin identified by electrospray ionisation mass spectrometry [2] Rapid Communications in Mass Spectrometry. 20: 3481-3482. PMID 17066374 DOI: 10.1002/Rcm.2746  0.32
2006 Griffiths WJ, Wang Y, Alvelius G, Liu S, Bodin K, Sjövall J. Analysis of oxysterols by electrospray tandem mass spectrometry. Journal of the American Society For Mass Spectrometry. 17: 341-62. PMID 16442307 DOI: 10.1016/J.Jasms.2005.10.012  0.32
2006 Wang Y, Hornshaw M, Alvelius G, Bodin K, Liu S, Sjövall J, Griffiths WJ. Matrix-assisted laser desorption/ionization high-energy collision-induced dissociation of steroids: analysis of oxysterols in rat brain. Analytical Chemistry. 78: 164-73. PMID 16383324 DOI: 10.1021/Ac051461B  0.32
2006 Khan MA, Wang Y, Heidelberger S, Alvelius G, Liu S, Sjövall J, Griffiths WJ. Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry. Steroids. 71: 42-53. PMID 16199070 DOI: 10.1016/J.Steroids.2005.08.002  0.32
2004 Lane CS, Nisar S, Griffiths WJ, Fuller BJ, Davidson BR, Hewes J, Welham KJ, Patterson LH. Identification of cytochrome P450 enzymes in human colorectal metastases and the surrounding liver: a proteomic approach. European Journal of Cancer (Oxford, England : 1990). 40: 2127-34. PMID 15341988 DOI: 10.1016/J.Ejca.2004.04.029  0.32
2004 Juntti-Berggren L, Refai E, Appelskog I, Andersson M, Imreh G, Dekki N, Uhles S, Yu L, Griffiths WJ, Zaitsev S, Leibiger I, Yang SN, Olivecrona G, Jörnvall H, Berggren PO. Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10090-4. PMID 15210953 DOI: 10.1073/Pnas.0403551101  0.32
2004 Rai DK, Green BN, Landin B, Alvelius G, Griffiths WJ. Accurate mass measurement and tandem mass spectrometry of intact globin chains identify the low proportion variant hemoglobin Lepore-Boston-Washington from the blood of a heterozygote Journal of Mass Spectrometry. 39: 289-294. PMID 15039936 DOI: 10.1002/Jms.581  0.32
2004 Nisar S, Lane CS, Wilderspin AF, Welham KJ, Griffiths WJ, Patterson LH. A proteomic approach to the identification of cytochrome P450 isoforms in male and female rat liver by nanoscale liquid chromatography-electrospray ionization-tandem mass spectrometry. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 382-6. PMID 15039290 DOI: 10.1124/Dmd.32.4.382  0.32
2003 Weiland MEL, Palm JED, Griffiths WJ, McCaffery JM, Svärd SG. Characterisation of alpha-1 giardin: An immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity International Journal For Parasitology. 33: 1341-1351. PMID 14527517 DOI: 10.1016/S0020-7519(03)00201-7  0.32
2003 Rai DK, Griffiths WJ, Landin B, Wild BJ, Alvelius G, Green BN. Accurate mass measurement by electrospray ionization quadrupole mass spectrometry: Detection of variants differing by <6 Da from normal in human hemoglobin heterozygotes Analytical Chemistry. 75: 1978-1982. PMID 12720330 DOI: 10.1021/Ac026228H  0.32
2003 Abraham-Nordling M, Gudmundsson GH, Grunewald J, Agerberth B, Griffiths WJ. Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: Guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents Rapid Communications in Mass Spectrometry. 17: 183-191. PMID 12539181 DOI: 10.1002/Rcm.891  0.32
2002 Jerremalm E, Videhult P, Alvelius G, Griffiths WJ, Bergman T, Eksborg S, Ehrsson H. Alkaline hydrolysis of oxaliplatin--isolation and identification of the oxalato monodentate intermediate. Journal of Pharmaceutical Sciences. 91: 2116-21. PMID 12226839 DOI: 10.1002/Jps.10201  0.32
2002 Rai DK, Landin B, Griffiths WJ, Alvelius G. Identification of N-terminal acetylation in Hb Raleigh (β1Val →Ac-Ala) by electrospray tandem mass spectrometry Rapid Communications in Mass Spectrometry. 16: 1793-1796. PMID 12207369 DOI: 10.1002/Rcm.774  0.32
2002 Rai DK, Landin B, Alvelius G, Griffiths WJ. Electrospray tandem mass spectrometry of intact β-chain hemoglobin variants Analytical Chemistry. 74: 2097-2102. PMID 12033312 DOI: 10.1021/Ac011068F  0.32
2002 Rai DK, Landin B, Griffiths WJ, Alvelius G, Green BN. Characterization of the elusive disulfide bridge forming human Hb variant:Hb Ta-Li β83 (EF7)Gly → Cysby electrospray mass spectrometry Journal of the American Society For Mass Spectrometry. 13: 187-191. PMID 11838022 DOI: 10.1016/S1044-0305(01)00349-X  0.32
1998 Tornhamre S, Sjölinder M, Lindberg A, Ericsson I, Näsman-Glaser B, Griffiths WJ, Lindgren JA. Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity European Journal of Biochemistry. 251: 227-235. PMID 9492288 DOI: 10.1046/J.1432-1327.1998.2510227.X  0.32
1996 Griffiths WJ, Yang Y, Sjövall J, Lindgren JA. Electrospray/collision-induced dissociation mass spectrometry of mono-, di- and tri-hydroxylated lipoxygenase products, including leukotrienes of the B-series and lipoxins Rapid Communications in Mass Spectrometry. 10: 183-196. PMID 8616266 DOI: 10.1002/(Sici)1097-0231(19960131)10:2<183::Aid-Rcm456>3.0.Co;2-W  0.32
1995 Yang Y, Griffiths WJ, Lindgren JA, Sjövall J. Liquid chromatography/mass spectrometry with collision-induced dissociation of arachidonic acid metabolites derivatized with aminobenzenesulphonic acid Rapid Communications in Mass Spectrometry : Rcm. 9: 289-299. PMID 7756703 DOI: 10.1002/Rcm.1290090407  0.32
1994 Griffiths WJ, de Brito AN, Correia N, Severs JC, Harris FM. Triplet electronic states of the doubly charged ion of acetone: a combined theoretical and experimental study International Journal of Mass Spectrometry and Ion Processes. 134: 197-201. DOI: 10.1016/0168-1176(94)03983-6  0.32
1993 Griffiths WJ, Svensson S, De Brito AN, Correia N, Wannberg B, Langford ML, Harris FM, Liegener CM, Ågren H. Doubly ionized states of hexafluorobenzene studied by high-resolution Auger electron and double-charge-transfer spectroscopies Journal of the Chemical Society, Faraday Transactions. 89: 1637-1643. DOI: 10.1039/Ft9938901637  0.32
1987 Griffiths WJ, Harris FM, Beynon JH. Experimental evidence for the stability of the NH4 ., H3O., H3S., and H3 . radicals by neutralization-reionization spectroscopy International Journal of Mass Spectrometry and Ion Processes. 77: 233-239. DOI: 10.1016/0168-1176(87)87010-6  0.32
1986 Griffiths WJ, Harris FM, Brenton AG, Beynon JH. Experimental determination of the ionization energy of the CH5 · radical International Journal of Mass Spectrometry and Ion Processes. 74: 317-321. DOI: 10.1016/0168-1176(86)85015-7  0.32
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