William J. Griffiths - Publications

Affiliations: 
Swansea University, Sketty, Wales, United Kingdom 

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Meljon A, Crick PJ, Yutuc E, Yau JL, Seckl JR, Theofilopoulos S, Arenas E, Wang Y, Griffiths WJ. Mining for Oxysterols in Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5. Biomolecules. 9. PMID 31013940 DOI: 10.3390/biom9040149  0.36
2019 Griffiths WJ, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Hoi-Yee Wu T, Goenka A, Ghosh A, Jones SA, Covey DF, Ory DS, Wang Y. Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology & Medicine. PMID 31009661 DOI: 10.1016/j.freeradbiomed.2019.04.020  0.36
2019 Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, ... ... Griffiths WJ, et al. First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography - Urgent need for harmonisation of analytical methods. The Journal of Steroid Biochemistry and Molecular Biology. PMID 30940596 DOI: 10.1016/j.jsbmb.2019.03.025  0.36
2019 Abdel-Khalik J, Crick PJ, Yutuc E, Wang Y, Griffiths WJ. Developing an Enzyme-Assisted Derivatization Method for Analysis of C Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. Molecules (Basel, Switzerland). 24. PMID 30736477 DOI: 10.3390/molecules24030597  0.36
2019 Theofilopoulos S, Abreu de Oliveira WA, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, Ullgren A, Cedazo-Minguez A, Björkhem I, Wang Y, Griffiths WJ, Arenas E. 24(),25-Epoxycholesterol and () overexpression promote midbrain dopaminergic neurogenesis . The Journal of Biological Chemistry. PMID 30655290 DOI: 10.1074/jbc.RA118.005639  0.36
2018 Griffiths WJ, Abdel-Khalik J, Yutuc E, Roman G, Warner M, Gustafsson JÅ, Wang Y. Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients. Free Radical Biology & Medicine. 134: 42-52. PMID 30578919 DOI: 10.1016/j.freeradbiomed.2018.12.020  0.36
2018 Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30471425 DOI: 10.1016/j.bbalip.2018.11.006  0.36
2018 Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Geilenkeuser WJ, Lövgren-Sandblom A, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Bretillon L, Browne RW, Caccia C, Cenarro A, Crick PJ, ... ... Griffiths WJ, et al. International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods. Biochimie. PMID 30063945 DOI: 10.1016/j.biochi.2018.07.016  0.36
2018 Abdel-Khalik J, Crick PJ, Yutuc E, DeBarber AE, Duell PB, Steiner RD, Laina I, Wang Y, Griffiths WJ. Identification of 7α,24-Dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-Dihydroxy-3-oxocholest-4-en-26-oic Acids in Human Cerebrospinal Fluid and Plasma. Biochimie. PMID 29960034 DOI: 10.1016/j.biochi.2018.06.020  0.36
2018 Griffiths WJ, Gilmore I, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Wu TH, Goenka A, Ghosh A, Jones SA, Wang Y. Identification Of Unusual Oxysterols And Bile acids With 7-Oxo Or 3β,5α,6β-Trihydroxy Functions In Human Plasma By Charge-Tagging Mass Spectrometry With Multistage Fragmentation. Journal of Lipid Research. PMID 29626102 DOI: 10.1194/jlr.D083246  0.36
2017 Griffiths WJ, Hearn T, Crick PJ, Abdel-Khalik J, Dickson A, Yutuc E, Wang Y. Charge-Tagging Liquid Chromatography-Mass Spectrometry Methodology Targeting Oxysterol Diastereoisomers. Chemistry and Physics of Lipids. PMID 28411018 DOI: 10.1016/j.chemphyslip.2017.04.004  0.36
2017 Griffiths WJ, Abdel-Khalik J, Yutuc E, Morgan AH, Gilmore I, Hearn T, Wang Y. Cholesterolomics: An update. Analytical Biochemistry. PMID 28087213 DOI: 10.1016/j.ab.2017.01.009  0.36
2016 Crick PJ, Griffiths WJ, Zhang J, Beibel M, Abdel-Khalik J, Kuhle J, Sailer AW, Wang Y. Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients. Molecular Neurobiology. PMID 27878760 DOI: 10.1007/s12035-016-0281-9  0.36
2016 Abdel-Khalik J, Yutuc E, Crick PJ, Gustafsson JÅ, Warner M, Roman G, Talbot K, Gray E, Griffiths WJ, Turner MR, Wang Y. Defective cholesterol metabolism in amyotrophic lateral sclerosis. Journal of Lipid Research. PMID 27811233 DOI: 10.1194/jlr.P071639  0.36
2016 Griffiths WJ, Abdel-Khalik J, Hearn T, Yutuc E, Morgan AH, Wang Y. Current trends in oxysterol research. Biochemical Society Transactions. 44: 652-8. PMID 27068984 DOI: 10.1042/BST20150255  0.36
2016 Griffiths WJ, Abdel-Khalik J, Crick PJ, Ogundare M, Shackleton CH, Tuschl K, Kwok MK, Bigger BW, Morris AA, Honda A, Xu L, Porter NA, Björkhem I, Clayton PT, Wang Y. Sterols and Oxysterols in Plasma from Smith-Lemi-Opitz Syndrome Patients. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26976653 DOI: 10.1016/j.jsbmb.2016.03.018  0.36
2016 Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, ... ... Griffiths WJ, et al. An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway. Plos Biology. 14: e1002364. PMID 26938778 DOI: 10.1371/journal.pbio.1002364  0.32
2015 Griffiths WJ, Abdel-Khalik J, Crick PJ, Yutuc E, Wang Y. New methods for analysis of oxysterols and related compounds by LC-MS. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26639636 DOI: 10.1016/j.jsbmb.2015.11.017  0.36
2015 Iuliano L, Crick PJ, Zerbinati C, Tritapepe L, Abdel-Khalik J, Poirot M, Wang Y, Griffiths WJ. Cholesterol metabolites exported from human brain. Steroids. 99: 189-93. PMID 25668615 DOI: 10.1016/j.steroids.2015.01.026  0.32
2015 Crick PJ, William Bentley T, Abdel-Khalik J, Matthews I, Clayton PT, Morris AA, Bigger BW, Zerbinati C, Tritapepe L, Iuliano L, Wang Y, Griffiths WJ. Quantitative charge-tags for sterol and oxysterol analysis. Clinical Chemistry. 61: 400-11. PMID 25512642 DOI: 10.1373/clinchem.2014.231332  0.36
2014 Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, et al. Cholestenoic acids regulate motor neuron survival via liver X receptors. The Journal of Clinical Investigation. 124: 4829-42. PMID 25271621 DOI: 10.1172/JCI68506  0.32
2014 Wang Y, Karu K, Meljon A, Turton J, Yau JL, Seckl JR, Wang Y, Griffiths WJ. 24S,25-Epoxycholesterol in mouse and rat brain. Biochemical and Biophysical Research Communications. 449: 229-34. PMID 24832732 DOI: 10.1016/j.bbrc.2014.05.012  0.32
2014 Björkhem I, Diczfalusy U, Lövgren-Sandblom A, Starck L, Jonsson M, Tallman K, Schirmer H, Ousager LB, Crick PJ, Wang Y, Griffiths WJ, Guengerich FP. On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. Journal of Lipid Research. 55: 1165-1172. PMID 24771866 DOI: 10.1194/jlr.P048603  0.36
2014 Autio KJ, Schmitz W, Nair RR, Selkälä EM, Sormunen RT, Miinalainen IJ, Crick PJ, Wang Y, Griffiths WJ, Reddy JK, Baes M, Hiltunen JK. Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice. The Biochemical Journal. 461: 125-35. PMID 24735479 DOI: 10.1042/BJ20130915  0.32
2014 Abdel-Khalik J, Crick PJ, Carter GD, Makin HL, Wang Y, Griffiths WJ. Studies on the analysis of 25-hydroxyvitamin D3 by isotope-dilution liquid chromatography-tandem mass spectrometry using enzyme-assisted derivatisation Biochemical and Biophysical Research Communications. 446: 745-750. PMID 24486315 DOI: 10.1016/j.bbrc.2014.01.088  0.36
2013 Saini R, Kataeva O, Schmidt AW, Wang Y, Meljon A, Griffiths WJ, Knölker HJ. Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol. Bioorganic & Medicinal Chemistry. 21: 5794-8. PMID 23910990 DOI: 10.1016/j.bmc.2013.07.015  0.32
2013 Meljon A, Watson GL, Wang Y, Shackleton CH, Griffiths WJ. Analysis by liquid chromatography-mass spectrometry of sterols and oxysterols in brain of the newborn Dhcr7(Δ3-5/T93M) mouse: a model of Smith-Lemli-Opitz syndrome. Biochemical Pharmacology. 86: 43-55. PMID 23500538 DOI: 10.1016/j.bcp.2013.03.003  0.32
2013 Theofilopoulos S, Wang Y, Kitambi SS, Sacchetti P, Sousa KM, Bodin K, Kirk J, Saltó C, Gustafsson M, Toledo EM, Karu K, Gustafsson JÃ…, Steffensen KR, Ernfors P, Sjövall J, ... Griffiths WJ, et al. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology. 9: 126-33. PMID 23292650 DOI: 10.1038/nchembio.1156  0.36
2013 Parker JE, Warrilow AG, Cools HJ, Fraaije BA, Lucas JA, Rigdova K, Griffiths WJ, Kelly DE, Kelly SL. Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase. Applied and Environmental Microbiology. 79: 1639-45. PMID 23275516 DOI: 10.1128/AEM.03246-12  0.32
2013 Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, ... ... Griffiths WJ, et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity. 38: 106-18. PMID 23273843 DOI: 10.1016/j.immuni.2012.11.004  0.32
2013 Chen Y, Ogundare M, Williams CM, Wang Y, Wang Y, Sewell GW, Smith PJ, Rahman FZ, O'Shea N, Segal AW, Griffiths WJ. Shotgun cholanomics of ileal fluid. Biochimie. 95: 461-3. PMID 22986022 DOI: 10.1016/j.biochi.2012.09.004  0.32
2012 Meljon A, Theofilopoulos S, Shackleton CH, Watson GL, Javitt NB, Knölker HJ, Saini R, Arenas E, Wang Y, Griffiths WJ. Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. Journal of Lipid Research. 53: 2469-83. PMID 22891291 DOI: 10.1194/jlr.D028233  0.32
2011 Rai DK, Brunton NP, Koidis A, Rawson A, McLoughlin P, Griffiths WJ. Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry Rapid Communications in Mass Spectrometry : Rcm. 25: 2231-2239. PMID 21735506 DOI: 10.1002/rcm.5103  0.32
2011 Björkhem I, Diczfalusy U, Olsson T, Russell DW, McDonald JG, Wang Y, Griffiths WJ. Detecting oxysterols in the human circulation. Nature Immunology. 12: 577; author reply 57. PMID 21685947 DOI: 10.1038/ni0711-577a  0.32
2011 Karu K, Turton J, Wang Y, Griffiths WJ. Nano-liquid chromatography-tandem mass spectrometry analysis of oxysterols in brain: monitoring of cholesterol autoxidation. Chemistry and Physics of Lipids. 164: 411-24. PMID 21575613 DOI: 10.1016/j.chemphyslip.2011.04.011  0.32
2010 Ogundare M, Theofilopoulos S, Lockhart A, Hall LJ, Arenas E, Sjövall J, Brenton AG, Wang Y, Griffiths WJ. Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain? The Journal of Biological Chemistry. 285: 4666-79. PMID 19996111 DOI: 10.1074/jbc.M109.086678  0.32
2009 Alander J, Lengqvist J, Holm PJ, Svensson R, Gerbaux P, Heuvel RH, Hebert H, Griffiths WJ, Armstrong RN, Morgenstern R. Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione. Archives of Biochemistry and Biophysics. 487: 42-8. PMID 19416719 DOI: 10.1016/j.abb.2009.04.009  0.32
2009 Wang Y, Sousa KM, Bodin K, Theofilopoulos S, Sacchetti P, Hornshaw M, Woffendin G, Karu K, Sjövall J, Arenas E, Griffiths WJ. Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular Biosystems. 5: 529-41. PMID 19381367 DOI: 10.1039/b819502a  0.32
2008 Claesson HE, Griffiths WJ, Brunnström A, Schain F, Andersson E, Feltenmark S, Johnson HA, Porwit A, Sjöberg J, Björkholm M. Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma. The Febs Journal. 275: 4222-34. PMID 18647347 DOI: 10.1111/j.1742-4658.2008.06570.x  0.32
2008 Griffiths WJ, Hornshaw M, Woffendin G, Baker SF, Lockhart A, Heidelberger S, Gustafsson M, Sjövall J, Wang Y. Discovering oxysterols in plasma: a window on the metabolome. Journal of Proteome Research. 7: 3602-12. PMID 18605750 DOI: 10.1021/pr8001639  0.32
2008 Griffiths WJ, Wang Y, Karu K, Samuel E, McDonnell S, Hornshaw M, Shackleton C. Potential of sterol analysis by liquid chromatography-tandem mass spectrometry for the prenatal diagnosis of Smith-Lemli-Opitz syndrome. Clinical Chemistry. 54: 1317-24. PMID 18556335 DOI: 10.1373/clinchem.2007.100644  0.32
2008 Wang Y, Muneton S, Sjövall J, Jovanovic JN, Griffiths WJ. The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. Journal of Proteome Research. 7: 1606-14. PMID 18303831 DOI: 10.1021/pr7006076  0.32
2007 Lane CS, Wang Y, Betts R, Griffiths WJ, Patterson LH. Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling. Molecular & Cellular Proteomics : McP. 6: 953-62. PMID 17296599 DOI: 10.1074/mcp.M600296-MCP200  0.32
2007 Karu K, Hornshaw M, Woffendin G, Bodin K, Hamberg M, Alvelius G, Sjövall J, Turton J, Wang Y, Griffiths WJ. Liquid chromatography-mass spectrometry utilizing multi-stage fragmentation for the identification of oxysterols. Journal of Lipid Research. 48: 976-87. PMID 17251593 DOI: 10.1194/jlr.M600497-JLR200  0.32
2007 Wang Y, Karu K, Griffiths WJ. Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie. 89: 182-91. PMID 17126470 DOI: 10.1016/j.biochi.2006.10.008  0.32
2006 Rai DK, Landin B, Alvelius G, Griffiths WJ. Haemoglobin Södertälje (β118 Phe→Val): A new mutation in human haemoglobin identified by electrospray ionisation mass spectrometry [2] Rapid Communications in Mass Spectrometry. 20: 3481-3482. PMID 17066374 DOI: 10.1002/rcm.2746  0.32
2006 Griffiths WJ, Wang Y, Alvelius G, Liu S, Bodin K, Sjövall J. Analysis of oxysterols by electrospray tandem mass spectrometry. Journal of the American Society For Mass Spectrometry. 17: 341-62. PMID 16442307 DOI: 10.1016/j.jasms.2005.10.012  0.32
2006 Wang Y, Hornshaw M, Alvelius G, Bodin K, Liu S, Sjövall J, Griffiths WJ. Matrix-assisted laser desorption/ionization high-energy collision-induced dissociation of steroids: analysis of oxysterols in rat brain. Analytical Chemistry. 78: 164-73. PMID 16383324 DOI: 10.1021/ac051461b  0.32
2006 Khan MA, Wang Y, Heidelberger S, Alvelius G, Liu S, Sjövall J, Griffiths WJ. Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry. Steroids. 71: 42-53. PMID 16199070 DOI: 10.1016/j.steroids.2005.08.002  0.32
2004 Juntti-Berggren L, Refai E, Appelskog I, Andersson M, Imreh G, Dekki N, Uhles S, Yu L, Griffiths WJ, Zaitsev S, Leibiger I, Yang SN, Olivecrona G, Jörnvall H, Berggren PO. Apolipoprotein CIII promotes Ca2+-dependent beta cell death in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10090-4. PMID 15210953 DOI: 10.1073/pnas.0403551101  0.32
2004 Rai DK, Green BN, Landin B, Alvelius G, Griffiths WJ. Accurate mass measurement and tandem mass spectrometry of intact globin chains identify the low proportion variant hemoglobin Lepore-Boston-Washington from the blood of a heterozygote Journal of Mass Spectrometry. 39: 289-294. PMID 15039936 DOI: 10.1002/jms.581  0.32
2003 Weiland MEL, Palm JED, Griffiths WJ, McCaffery JM, Svärd SG. Characterisation of alpha-1 giardin: An immunodominant Giardia lamblia annexin with glycosaminoglycan-binding activity International Journal For Parasitology. 33: 1341-1351. PMID 14527517 DOI: 10.1016/S0020-7519(03)00201-7  0.32
2003 Rai DK, Griffiths WJ, Landin B, Wild BJ, Alvelius G, Green BN. Accurate mass measurement by electrospray ionization quadrupole mass spectrometry: Detection of variants differing by <6 Da from normal in human hemoglobin heterozygotes Analytical Chemistry. 75: 1978-1982. PMID 12720330 DOI: 10.1021/ac026228h  0.32
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