| Year |
Citation |
Score |
| 2018 |
Zorba A, Nguyen C, Xu Y, Starr J, Borzilleri K, Smith J, Zhu H, Farley KA, Ding W, Schiemer J, Feng X, Chang JS, Uccello DP, Young JA, Garcia-Irrizary CN, ... ... Gilbert AM, et al. Delineating the role of cooperativity in the design of potent PROTACs for BTK. Proceedings of the National Academy of Sciences of the United States of America. PMID 30012605 DOI: 10.1073/Pnas.1803662115 |
0.426 |
|
| 2018 |
McAllister LA, Butler CR, Mente S, O'Neil SV, Fonseca KR, Piro JR, Cianfrogna JA, Foley TL, Gilbert AM, Harris AR, Helal CJ, Johnson DS, Montgomery JI, Nason DM, Noell S, et al. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation. Journal of Medicinal Chemistry. PMID 29498843 DOI: 10.1021/Acs.Jmedchem.8B00070 |
0.426 |
|
| 2017 |
Thorarensen A, Dowty ME, Banker ME, Juba BM, Jussif J, Lin T, Vincent F, Czerwinski RM, Casimiro-Garcia A, Unwalla R, Trujillo JI, Liang S, Balbo P, Che Y, Gilbert AM, et al. The design of a Janus Kinase 3 (JAK3) specific inhibitor 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans. Journal of Medicinal Chemistry. PMID 28139931 DOI: 10.1021/Acs.Jmedchem.6B01694 |
0.429 |
|
| 2016 |
Leung L, Yang X, Strelevitz TJ, Montgomery J, Brown MF, Zientek MA, Banfield C, Gilbert AM, Thorarensen A, Dowty ME. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27784718 DOI: 10.1124/Dmd.116.072983 |
0.308 |
|
| 2016 |
Dahal UP, Gilbert AM, Obach RS, Flanagan ME, Chen JM, Garcia-Irizarry C, Starr JT, Schuff B, Uccello DP, Young JA. Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design:: N -α-acetyl-l-lysine as an amine nucleophile Medchemcomm. 7: 864-872. DOI: 10.1039/C6Md00017G |
0.405 |
|
| 2014 |
Flanagan ME, Abramite JA, Anderson DP, Aulabaugh A, Dahal UP, Gilbert AM, Li C, Montgomery J, Oppenheimer SR, Ryder T, Schuff BP, Uccello DP, Walker GS, Wu Y, Brown MF, et al. Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors. Journal of Medicinal Chemistry. 57: 10072-9. PMID 25375838 DOI: 10.1021/Jm501412A |
0.426 |
|
| 2012 |
Noe MC, Gilbert AM. Targeted Covalent Enzyme Inhibitors Annual Reports in Medicinal Chemistry. 47: 413-439. DOI: 10.1016/B978-0-12-396492-2.00027-8 |
0.412 |
|
| 2011 |
Gilbert AM, Bikker JA, O'Neil SV. Advances in the development of novel aggrecanase inhibitors. Expert Opinion On Therapeutic Patents. 21: 1-12. PMID 21110709 DOI: 10.1517/13543776.2011.539204 |
0.412 |
|
| 2011 |
Pellicciari R, Camaioni E, Gilbert AM, Macchiarulo A, Bikker JA, Shah F, Bard J, Costantino G, Gioiello A, Robertson GM, Sabbatini P, Venturoni F, Liscio P, Carotti A, Bellocchi D, et al. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ Medchemcomm. 2: 559-565. DOI: 10.1039/C1Md00021G |
0.409 |
|
| 2010 |
Bursavich MG, Brooijmans N, Feldberg L, Hollander I, Kim S, Lombardi S, Park K, Mallon R, Gilbert AM. Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies. Bioorganic & Medicinal Chemistry Letters. 20: 2586-90. PMID 20303263 DOI: 10.1016/J.Bmcl.2010.02.082 |
0.413 |
|
| 2010 |
Gilbert AM, Nowak P, Brooijmans N, Bursavich MG, Dehnhardt C, Santos ED, Feldberg LR, Hollander I, Kim S, Lombardi S, Park K, Venkatesan AM, Mallon R. Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorganic & Medicinal Chemistry Letters. 20: 636-9. PMID 19969455 DOI: 10.1016/J.Bmcl.2009.11.051 |
0.306 |
|
| 2010 |
Venkatesan AM, Dehnhardt CM, Chen Z, Santos ED, Dos Santos O, Bursavich M, Gilbert AM, Ellingboe JW, Ayral-Kaloustian S, Khafizova G, Brooijmans N, Mallon R, Hollander I, Feldberg L, Lucas J, et al. Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 653-6. PMID 19954970 DOI: 10.1016/J.Bmcl.2009.11.057 |
0.308 |
|
| 2008 |
Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 18: 6454-7. PMID 18974001 DOI: 10.1016/J.Bmcl.2008.10.065 |
0.431 |
|
| 2007 |
Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 17: 5630-3. PMID 17804234 DOI: 10.1016/J.Bmcl.2007.07.048 |
0.416 |
|
| 2007 |
Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorganic & Medicinal Chemistry Letters. 17: 1189-92. PMID 17210252 DOI: 10.1016/J.Bmcl.2006.12.020 |
0.422 |
|
| 2007 |
Bursavich MG, Gilbert AM, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 17: 1185-8. PMID 17210251 DOI: 10.1016/J.Bmcl.2006.12.027 |
0.46 |
|
| 2005 |
Bursavich MG, Lombardi S, Gilbert AM. Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines. Organic Letters. 7: 4113-6. PMID 16146365 DOI: 10.1002/CHIN.200604148 |
0.461 |
|
| 1999 |
Miller RA, Gilbert AM, Xue S, Wulff WD. Synthetic studies towards the total synthesis of olivin using Fischer carbene complexes: Synthesis of the 1,6,8-trioxygenated tricyclic core via the benzannulation reaction Synthesis. 80-84. DOI: 10.1055/S-1999-3670 |
0.624 |
|
| 1999 |
Gilbert AM, Miller R, Wulff WD. Synthetic studies towards the total synthesis of olivin: Synthesis of a fully functionalized alkyne appropriate for the benzannulation reaction Tetrahedron. 55: 1607-1630. DOI: 10.1016/S0040-4020(98)01206-X |
0.627 |
|
| 1995 |
Wulff WD, Gilbert AM, Hsung RP, Rahm A. Phenol formation from the reactions of amino-stabilized alkenyl Fischer carbene complexes Journal of Organic Chemistry. 60: 4566-4575. DOI: 10.1021/Jo00119A039 |
0.656 |
|
| 1994 |
Wulff WD, Bax BM, Brandvold TA, Chan KS, Gilbert AM, Hsung RP, Mitchell J, Clardy J. Reactions of group 6 fischer carbene complexes with alkynes: Effect of the metal on the product distribution and the isolation of a nontautomerized cyclohexadienone complex Organometallics. 13: 102-126. DOI: 10.1021/Om00013A021 |
0.655 |
|
| 1994 |
Gilbert AM, Wulff WD. Palladium-catalyzed cross-coupling of arene-chromium tricarbonyl triflate complexes Journal of the American Chemical Society. 116: 7449-7450. DOI: 10.1021/Ja00095A075 |
0.58 |
|
| 1994 |
Semmelhack MF, Ho S, Cohen D, Steigerwald M, Lee MC, Lee G, Gilbert AM, Wulff WD, Ball RG. Metal-Catalyzed Cyclopropene Rearrangements for Benzannulation: Evaluation of an Anthraquinone Synthesis Pathway and Reevaluation of the Parallel Approach via Carbene-Chromium Complexes Journal of the American Chemical Society. 116: 7108-7122. DOI: 10.1021/Ja00095A014 |
0.655 |
|
| 1994 |
Semmelhack MF, Ho S, Cohen D, Steigerwald M, Lee MC, Lee G, Gilbert AM, Wutff WD, Ball RG. Metal-catalyzed cyclopropene rearrangements for benzannulation: Evaluation of an anthraquinone synthesis pathway and reevaluation of the parallel approach via carbene-chromium complexes Journal of the American Chemical Society. 116: 7108-7122. |
0.578 |
|
| 1993 |
Gilbert AM, Katz TJ, Geiger WE, Robben MP, Rheingold AL. Synthesis and properties of an optically active helical bis-cobaltocenium ion Journal of the American Chemical Society. 115: 3199-3211. DOI: 10.1021/Ja00061A019 |
0.554 |
|
| 1993 |
Katz TJ, Sudhakar A, Teasley MF, Gilbert AM, Geiger WE, Robben MP, Wuensch M, Ward MD. Synthesis and properties of optically active helical metallocene oligomers Journal of the American Chemical Society. 115: 3182-3198. DOI: 10.1021/Ja00061A018 |
0.554 |
|
| 1993 |
Katz TJ, Gilbert AM, Huttenloch ME, Min-Min G, Brintzinger HH. Palladium-catalyzed coupling of 2,2t - ́dihalobiaryls with metallated cyclopentenes. An easy synthesis for spiro[cyclopentene-1,9-[9H]fluorene]s Tetrahedron Letters. 34: 3551-3554. DOI: 10.1016/S0040-4039(00)73633-1 |
0.609 |
|
| 1992 |
Huttenloch ME, Diebold J, Rief U, Brintzinger HH, Gilbert AM, Katz TJ. Biphenyl-bridged metallocenes that are chiral, configurationally stable, and free of diastereomers Organometallics. 11: 3600-3607. DOI: 10.1021/Om00059A024 |
0.51 |
|
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