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Nibaldo Inestrosa, Ph.D. - Publications

Affiliations: 
Departamento de Biología Celular y Molecular Pontificia Universidad Católica de Chile, Santiago, Región Metropolitana, Chile 
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47/417 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, ... ... Inestrosa NC, et al. Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature Cell Biology. PMID 31201389 DOI: 10.1038/S41556-019-0355-9  0.523
2019 Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, ... ... Inestrosa NC, et al. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature Cell Biology. PMID 31110288 DOI: 10.1038/S41556-019-0329-Y  0.543
2016 Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guivernau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, et al. Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons. Oncotarget. PMID 27557499 DOI: 10.18632/Oncotarget.11417  0.345
2015 Fuenzalida M, Espinoza C, Pérez MÁ, Tapia-Rojas C, Cuitino L, Brandan E, Inestrosa NC. Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Neurobiology of Disease. PMID 26626079 DOI: 10.1016/J.Nbd.2015.11.018  0.58
2015 Parodi J, Montecinos-Oliva C, Varas R, Alfaro IE, Serrano FG, Varas-Godoy M, Muñoz FJ, Cerpa W, Godoy JA, Inestrosa NC. Wnt5a inhibits K(+) currents in hippocampal synapses through nitric oxide production. Molecular and Cellular Neurosciences. 68: 314-22. PMID 26311509 DOI: 10.1016/J.Mcn.2015.08.011  0.713
2015 Alfaro IE, Varela-Nallar L, Varas-Godoy M, Inestrosa NC. The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons. Molecular and Cellular Neurosciences. 67: 22-30. PMID 26003414 DOI: 10.1016/j.mcn.2015.05.002  0.718
2015 Parodi J, Montecinos-Oliva C, Varas R, Alfaro IE, Serrano FG, Varas-Godoy M, Muñoz FJ, Cerpa W, Godoy JA, Inestrosa NC. Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production Molecular and Cellular Neuroscience. 68: 314-322. DOI: 10.1016/j.mcn.2015.08.011  0.673
2014 Cisternas P, Henriquez JP, Brandan E, Inestrosa NC. Wnt signaling in skeletal muscle dynamics: myogenesis, neuromuscular synapse and fibrosis. Molecular Neurobiology. 49: 574-89. PMID 24014138 DOI: 10.1007/S12035-013-8540-5  0.58
2013 Quintanilla RA, Godoy JA, Alfaro I, Cabezas D, von Bernhardi R, Bronfman M, Inestrosa NC. Thiazolidinediones promote axonal growth through the activation of the JNK pathway. Plos One. 8: e65140. PMID 23741474 DOI: 10.1371/Journal.Pone.0065140  0.681
2011 Cerpa W, Gambrill A, Inestrosa NC, Barria A. Regulation of NMDA-receptor synaptic transmission by Wnt signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9466-71. PMID 21715611 DOI: 10.1523/Jneurosci.6311-10.2011  0.69
2011 Mesa R, Luo S, Hoover CM, Miller K, Minniti A, Inestrosa N, Nonet ML. HID-1, a new component of the peptidergic signaling pathway. Genetics. 187: 467-83. PMID 21115972 DOI: 10.1534/Genetics.110.121996  0.356
2010 Varela-Nallar L, Alfaro IE, Serrano FG, Parodi J, Inestrosa NC. Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proceedings of the National Academy of Sciences of the United States of America. 107: 21164-9. PMID 21084636 DOI: 10.1073/pnas.1010011107  0.707
2010 Reale M, Brenner T, Greig NH, Inestrosa N, Paleacu D. Neuroinflammation, AD, and Dementia. International Journal of Alzheimer's Disease. 2010. PMID 20871836 DOI: 10.4061/2010/974026  0.303
2009 Varela-Nallar L, Grabowski CP, Alfaro IE, Alvarez AR, Inestrosa NC. Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function. Neural Development. 4: 41. PMID 19883499 DOI: 10.1186/1749-8104-4-41  0.73
2009 Farías GG, Alfaro IE, Cerpa W, Grabowski CP, Godoy JA, Bonansco C, Inestrosa NC. Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons. The Journal of Biological Chemistry. 284: 15857-66. PMID 19332546 DOI: 10.1074/Jbc.M808986200  0.717
2008 Colombres M, Henríquez JP, Reig GF, Scheu J, Calderón R, Alvarez A, Brandan E, Inestrosa NC. Heparin activates Wnt signaling for neuronal morphogenesis. Journal of Cellular Physiology. 216: 805-15. PMID 18449906 DOI: 10.1002/Jcp.21465  0.557
2008 Cerpa W, Godoy JA, Alfaro I, Farías GG, Metcalfe MJ, Fuentealba R, Bonansco C, Inestrosa NC. Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. The Journal of Biological Chemistry. 283: 5918-27. PMID 18096705 DOI: 10.1074/Jbc.M705943200  0.717
2004 Aldunate R, Casar JC, Brandan E, Inestrosa NC. Structural and functional organization of synaptic acetylcholinesterase Brain Research Reviews. 47: 96-104. PMID 15572165 DOI: 10.1016/J.Brainresrev.2004.07.019  0.593
2004 Casar JC, Cabello-Verrugio C, Olguin H, Aldunate R, Inestrosa NC, Brandan E. Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: Requirement of syndecan-3 for successful fiber formation Journal of Cell Science. 117: 73-84. PMID 14627628 DOI: 10.1242/Jcs.00828  0.561
1998 Casanueva OI, García-Huidobro T, Campos EO, Aldunate R, Garrido J, Inestrosa NC. A major portion of synaptic basal lamina acetylcholinesterase is detached by high salt- and heparin-containing buffers from rat diaphragm muscle and Torpedo electric organ. The Journal of Biological Chemistry. 273: 4258-65. PMID 9461624 DOI: 10.1074/jbc.273.7.4258  0.308
1995 Rodriguez SR, Riquelme C, Campos EO, Chavez P, Brandan E, Inestrosa NC. Behavioral Responses of Concholepas concholepas (Bruguière, 1789) Larvae to Natural and Artificial Settlement Cues and Microbial Films. The Biological Bulletin. 189: 272-279. PMID 29244580 DOI: 10.2307/1542144  0.487
1993 Brandan E, Inestrosa NC. Extracellular matrix components and amyloid in neuritic plaques of Alzheimer's disease. General Pharmacology. 24: 1063-8. PMID 8270163 DOI: 10.1016/0306-3623(93)90350-7  0.512
1993 Krauss RY, Alvarez J, Inestrosa NC. A neurofilament polypeptide and the glial fibrillary acidic protein share common epitopes in the variable region. Neuroscience Letters. 161: 137-40. PMID 7505907  0.474
1992 Gonzalez R, Urrea R, Gonzalez M, Inestrosa NC, Brandan E. Isolation of proteoglycans synthesized by rat heart: evidence for the presence of several distinct forms. General Pharmacology. 23: 249-55. PMID 1639240 DOI: 10.1016/0306-3623(92)90020-K  0.505
1992 Brandan E, González M, Inestrosa NC, Tremblay C, Urrea R. A high molecular weight proteoglycan is differentially expressed during development of the mollusc Concholepas concholepas (Mollusca; Gastropoda; Muricidae). The Journal of Experimental Zoology. 264: 363-71. PMID 1460434 DOI: 10.1002/Jez.1402640402  0.531
1992 Alvarez J, Moreno RD, Llanos O, Inestrosa NC, Brandan E, Colby T, Esch FS. Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases. Neuroscience Letters. 144: 130-4. PMID 1436693 DOI: 10.1016/0304-3940(92)90733-N  0.518
1990 Fadic R, Brandan E, Inestrosa NC. Motor nerve regulates muscle extracellular matrix proteoglycan expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3516-23. PMID 2230941 DOI: 10.1523/Jneurosci.10-11-03516.1990  0.582
1990 Perelman A, Abeijon C, Hirschberg CB, Inestrosa NC, Brandan E. Differential association and distribution of acetyl- and butyrylcholinesterases within rat liver subcellular organelles. The Journal of Biological Chemistry. 265: 214-20. PMID 2152920  0.518
1990 Inestrosa NC, Labarca R, Perelman A, Campos EO, Araneda R, Gonzalez M, Brandan E, Sanchez JP, Gonzalez-Plaza R. Biotechnological aspects in loco larvae Archivos De Biologia Y Medicina Experimentales. 23: 179-186. PMID 1966831  0.515
1990 Brandan E, González M, González-Plaza R, Inestrosa NC. Increase of macromolecule synthesis after hatching of Concholepas concholepas veliger larvae: Effect of sulfate in the synthesis of proteoglycans Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 96: 613-619. DOI: 10.1016/0305-0491(90)90065-2  0.508
1990 Gonzalez M, Perelman A, Fuentes ME, Castilla JC, Labarca R, Brandan E, Gonzalez-Plaza R, Inestrosa NC. Neurotransmitter-related enzyme acetylcholinesterase in juveniles of Concholepas concholepas (mollusca; gastropoda; muricidae) Journal of Experimental Zoology. 255: 1-8. DOI: 10.1002/Jez.1402550102  0.528
1989 Allende ML, Krauss RY, Tremblay C, Alvarez J, Inestrosa NC. Anti-200 kDa neurofilament antibody cross-reacts with microtubule-associated protein-2 (MAP-2). Journal of Neuroscience Research. 22: 130-3. PMID 2468783 DOI: 10.1002/Jnr.490220204  0.493
1987 Brandan E, Inestrosa NC. Co-solubilization of asymmetric acetylcholinesterase and dermatan sulfate proteoglycan from the extracellular matrix of rat skeletal muscles. Febs Letters. 213: 159-63. PMID 3556575 DOI: 10.1016/0014-5793(87)81483-7  0.562
1987 Brandan E, Inestrosa NC. Isolation of the heparan sulfate proteoglycans from the extracellular matrix of rat skeletal muscle. Journal of Neurobiology. 18: 271-82. PMID 2955079 DOI: 10.1002/Neu.480180303  0.568
1987 Cross D, Allende ML, Krauss RY, Fuentes ME, Kaltwasser G, Alvarez J, Inestrosa NC. Biosynthesis of the neurofilament heavy subunit in Xenopus oocytes microinjected with rat brain poly(A)+ RNA. Molecular Biology Reports. 12: 265-71. PMID 2893252 DOI: 10.1007/Bf00444678  0.471
1987 Inestrosa NC, Nader HB, Garrido J, Sampaio LO, Brandan E, Dietrich CP. Glycosaminoglycan composition of electric organ basement membranes. Journal of Neuroscience Research. 17: 256-64. PMID 2439701 DOI: 10.1002/Jnr.490170309  0.502
1986 Brandan E, Llona I, Inestrosa NC. Heparin-acetylcholinesterase interaction: Specific detachment of class I-A forms and binding of class I and II-A forms to heparin-agarose. Neurochemistry International. 9: 75-84. PMID 20493103 DOI: 10.1016/0197-0186(86)90034-3  0.52
1986 Brandan E, Inestrosa NC. The synaptic form of acetylcholinesterase binds to cell-surface heparan sulfate proteoglycans. Journal of Neuroscience Research. 15: 185-96. PMID 2937928 DOI: 10.1002/Jnr.490150208  0.557
1985 Brandan E, Maldonado M, Garrido J, Inestrosa NC. Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans. The Journal of Cell Biology. 101: 985-92. PMID 3161900 DOI: 10.1083/Jcb.101.3.985  0.557
1985 Inestrosa NC, Matthew WD, Reiness CG, Hall ZW, Reichardt LF. Atypical distribution of asymmetric acetylcholinesterase in mutant PC12 pheochromocytoma cells lacking a cell surface heparan sulfate proteoglycan. Journal of Neurochemistry. 45: 86-94. PMID 3158721 DOI: 10.1111/j.1471-4159.1985.tb05478.x  0.538
1984 Ziskind-Conhaim L, Inestrosa NC, Hall ZW. Acetylcholinesterase is functional in embryonic rat muscle before its accumulation at the sites of nerve-muscle contact. Developmental Biology. 103: 369-77. PMID 6202574 DOI: 10.1016/0012-1606(84)90325-7  0.556
1984 Brandan E, Inestrosa NC. Binding of the asymmetric forms of acetylcholinesterase to heparin. The Biochemical Journal. 221: 415-22. PMID 6089739 DOI: 10.1042/Bj2210415  0.545
1983 Inestrosa NC, Miller JB, Silberstein L, Ziskind-Conhaim L, Hall ZW. Developmental regulation of 16S acetylcholinesterase and acetylcholine receptors in a mouse muscle cell line. Experimental Cell Research. 147: 393-405. PMID 6617773 DOI: 10.1016/0014-4827(83)90221-5  0.567
1982 Silberstein L, Inestrosa NC, Hall ZW. Aneural muscle cell cultures make synaptic basal lamina components. Nature. 295: 143-5. PMID 7035963 DOI: 10.1038/295143a0  0.617
1982 Inestrosa NC, Silberstein L, Hall ZW. Association of the synaptic form of acetylcholinesterase with extracellular matrix in cultured mouse muscle cells. Cell. 29: 71-9. PMID 6286145 DOI: 10.1016/0092-8674(82)90091-5  0.564
1981 Inestrosa NC, Reiness CG, Reichardt LF, Hall ZW. Cellular localization of the molecular forms of acetylcholinesterase in rat pheochromocytoma PC12 cells treated with nerve growth factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1260-7. PMID 7310486 DOI: 10.1523/Jneurosci.01-11-01260.1981  0.588
1979 Inestrosa NC, Mendez B, Luco JV. Acetylcholinesterase like that of skeletal muscle in smooth muscle reinnervated by a motor nerve. Nature. 280: 504-6. PMID 460431 DOI: 10.1038/280504A0  0.643
Low-probability matches (unlikely to be authored by this person)
1991 von Bernhardi R, Inestrosa NC. Dermatan sulfate and de-sulfated heparin solubilized collagen-tailed acetylcholinesterase from the rat neuromuscular junction. Brain Research. 529: 91-5. PMID 2282507 DOI: 10.1016/0006-8993(90)90814-R  0.293
1983 Torres JC, Inestrosa NC. Heparin solubilizes asymmetric acetylcholinesterase from rat neuromuscular junction. Febs Letters. 154: 265-8. PMID 6832369 DOI: 10.1016/0014-5793(83)80162-8  0.282
2022 Bonansco C, Cerpa W, Inestrosa NC. How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway. International Journal of Molecular Sciences. 24. PMID 36614149 DOI: 10.3390/ijms24010708  0.279
2018 Lira M, Arancibia D, Orrego PR, Montenegro-Venegas C, Cruz Y, García J, Leal-Ortiz S, Godoy JA, Gundelfinger ED, Inestrosa NC, Garner CC, Zamorano P, Torres VI. The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons. Molecular Neurobiology. PMID 30374940 DOI: 10.1007/s12035-018-1378-0  0.277
2014 Bustos FJ, Varela-Nallar L, Campos M, Henriquez B, Phillips M, Opazo C, Aguayo LG, Montecino M, Constantine-Paton M, Inestrosa NC, van Zundert B. PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors. Plos One. 9: e94037. PMID 24705401 DOI: 10.1371/journal.pone.0094037  0.277
2015 Dinamarca MC, Di Luca M, Godoy JA, Inestrosa NC. The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses. Biochemical and Biophysical Research Communications. 466: 66-71. PMID 26325471 DOI: 10.1016/j.bbrc.2015.08.107  0.276
2010 Cerpa W, Farías GG, Godoy JA, Fuenzalida M, Bonansco C, Inestrosa NC. Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Molecular Neurodegeneration. 5: 3. PMID 20205789 DOI: 10.1186/1750-1326-5-3  0.275
2010 Inestrosa NC, Arenas E. Emerging roles of Wnts in the adult nervous system. Nature Reviews. Neuroscience. 11: 77-86. PMID 20010950 DOI: 10.1038/Nrn2755  0.275
2019 Martinez M, Torres VI, Vio CP, Inestrosa NC. Canonical Wnt Signaling Modulates the Expression of Pre- and Postsynaptic Components in Different Temporal Patterns. Molecular Neurobiology. PMID 31745835 DOI: 10.1007/s12035-019-01785-5  0.273
1995 Deprez PN, Inestrosa NC. Two heparin-binding domains are present on the collagenic tail of asymmetric acetylcholinesterase. The Journal of Biological Chemistry. 270: 11043-6. PMID 7744733 DOI: 10.1074/Jbc.270.19.11043  0.273
2016 Ramírez VT, Ramos-Fernández E, Inestrosa NC. The Gα o Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons. Neural Plasticity. 2016: 4258171. PMID 26881110 DOI: 10.1155/2016/4258171  0.269
2012 Varela-Nallar L, Ramirez VT, Gonzalez-Billault C, Inestrosa NC. Frizzled receptors in neurons: from growth cones to the synapse. Cytoskeleton (Hoboken, N.J.). 69: 528-34. PMID 22407911 DOI: 10.1002/Cm.21022  0.267
2022 Álvarez-Ferradas C, Wellmann M, Morales K, Fuenzalida M, Cerpa W, Inestrosa NC, Bonansco C. Wnt-5a induces the conversion of silent to functional synapses in the hippocampus. Frontiers in Molecular Neuroscience. 15: 1024034. PMID 36385757 DOI: 10.3389/fnmol.2022.1024034  0.266
2008 Dinamarca MC, Colombres M, Cerpa W, Bonansco C, Inestrosa NC. Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway. Neuro-Degenerative Diseases. 5: 149-52. PMID 18322375 DOI: 10.1159/000113687  0.266
2013 Oliva CA, Vargas JY, Inestrosa NC. Wnts in adult brain: from synaptic plasticity to cognitive deficiencies. Frontiers in Cellular Neuroscience. 7: 224. PMID 24348327 DOI: 10.3389/fncel.2013.00224  0.266
2016 Vallejo D, Codocedo JF, Inestrosa NC. Posttranslational Modifications Regulate the Postsynaptic Localization of PSD-95. Molecular Neurobiology. PMID 26884267 DOI: 10.1007/s12035-016-9745-1  0.264
2011 Rebolledo DL, Aldunate R, Kohn R, Neira I, Minniti AN, Inestrosa NC. Copper reduces Aβ oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10149-58. PMID 21752991 DOI: 10.1523/JNEUROSCI.0336-11.2011  0.263
2012 Varela-Nallar L, Parodi J, Farías GG, Inestrosa NC. Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity. Neuro-Degenerative Diseases. 10: 23-6. PMID 22261402 DOI: 10.1159/000333360  0.263
1993 Rodriguez S, Ojeda F, Inestrosa N. Settlement of benthic marine invertebrates Marine Ecology Progress Series. 97: 193-207. DOI: 10.3354/Meps097193  0.262
2016 Ramírez VT, Ramos-Fernández E, Henríquez JP, Lorenzo A, Inestrosa NC. Wnt-5a/Frizzled9 receptor signaling through the Gαo/Gβγ complex regulates dendritic spine formation. The Journal of Biological Chemistry. PMID 27402827 DOI: 10.1074/jbc.M116.722132  0.261
2018 Zolezzi JM, Lindsay CB, Serrano FG, Ureta RC, Theoduloz C, Schmeda-Hirschmann G, Inestrosa NC. Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-β Injury in Hippocampal Neurons. Journal of Alzheimer's Disease : Jad. PMID 29660932 DOI: 10.3233/JAD-170701  0.259
2009 Cerpa W, Toledo EM, Varela-Nallar L, Inestrosa NC. The role of Wnt signaling in neuroprotection. Drug News & Perspectives. 22: 579-91. PMID 20140278 DOI: 10.1358/Dnp.2009.22.10.1443391  0.258
2012 Dinamarca MC, Ríos JA, Inestrosa NC. Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease. Frontiers in Physiology. 3: 464. PMID 23267328 DOI: 10.3389/fphys.2012.00464  0.258
2017 Torres VI, Vallejo D, Inestrosa NC. Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders. Neural Plasticity. 2017: 8081758. PMID 28331639 DOI: 10.1155/2017/8081758  0.258
2021 Ramos-Fernández E, Arrázola MS, Oliva CA, Arredondo SB, Varela-Nallar L, Inestrosa NC. Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase. Scientific Reports. 11: 7395. PMID 33795747 DOI: 10.1038/s41598-021-86708-y  0.255
2014 Vargas LM, Leal N, Estrada LD, González A, Serrano F, Araya K, Gysling K, Inestrosa NC, Pasquale EB, Alvarez AR. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. Plos One. 9: e92309. PMID 24658113 DOI: 10.1371/journal.pone.0092309  0.254
2006 Colombres M, Bejide M, Inestrosa N. AbstractPoster presentation: Tuesday posterP3-345: The Wnt-signaling pathway modulates the biochemical properties of N-cadherin. It’s implications on Alzheimer’s disease Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1615  0.252
2015 Inestrosa NC, Varela-Nallar L. Wnt signalling in neuronal differentiation and development. Cell and Tissue Research. 359: 215-23. PMID 25234280 DOI: 10.1007/s00441-014-1996-4  0.25
2015 Salech F, Varela-Nallar L, Arredondo S, Bustamante D, Vega DPdl, Inestrosa N, Behrens MI, Couve A. The role of klotho in the regulation of adult hippocampal neurogenesis Journal of the Neurological Sciences. 357. DOI: 10.1016/J.Jns.2015.08.865  0.25
2021 Vallejo D, Lindsay CB, González-Billault C, Inestrosa NC. Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons. Journal of Neurochemistry. PMID 34107066 DOI: 10.1111/jnc.15448  0.249
1991 von Bernhardi R, Ayal H, Inestrosa NC. Carrageenans solubilize asymmetric acetylcholinesterase from nicotinic cholinergic synapses. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 96: 77-81. PMID 1980885 DOI: 10.1016/0742-8413(90)90047-D  0.246
2010 Cuitino L, Godoy JA, Farías GG, Couve A, Bonansco C, Fuenzalida M, Inestrosa NC. Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8411-20. PMID 20573888 DOI: 10.1523/JNEUROSCI.5736-09.2010  0.242
2013 Rosso SB, Inestrosa NC. WNT signaling in neuronal maturation and synaptogenesis. Frontiers in Cellular Neuroscience. 7: 103. PMID 23847469 DOI: 10.3389/fncel.2013.00103  0.239
2014 Vargas JY, Fuenzalida M, Inestrosa NC. In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2191-202. PMID 24501359 DOI: 10.1523/JNEUROSCI.0862-13.2014  0.239
2014 Muñoz FJ, Godoy JA, Cerpa W, Poblete IM, Huidobro-Toro JP, Inestrosa NC. Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons. Biochemical and Biophysical Research Communications. 444: 189-94. PMID 24440698 DOI: 10.1016/J.Bbrc.2014.01.031  0.237
1988 Fadić R, Soza MA, Inestrosa NC. Changes in contralateral synaptic acetylcholinesterase following motor nerve section in rats. Neuroscience Letters. 90: 229-33. PMID 3412647 DOI: 10.1016/0304-3940(88)90817-8  0.237
2011 Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC. The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry. 50: 8127-37. PMID 21838267 DOI: 10.1021/Bi201246T  0.237
2015 Codocedo JF, Montecinos-Oliva C, Inestrosa NC. Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers. Frontiers in Cellular Neuroscience. 9: 227. PMID 26124704 DOI: 10.3389/fncel.2015.00227  0.237
2014 Cerpa W, Ramos-Fernández E, Inestrosa NC. Modulation of the NMDA Receptor Through Secreted Soluble Factors. Molecular Neurobiology. PMID 25429903 DOI: 10.1007/S12035-014-9009-X  0.235
2015 Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC. WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Experimental Neurology. 264: 14-25. PMID 25450465 DOI: 10.1016/j.expneurol.2014.11.005  0.235
1996 Martínez G, Saleh F, Mettifogo L, Campos E, Inestrosa N. Monoamines and the release of gametes by the scallopArgopecten purpuratus The Journal of Experimental Zoology. 274: 365-372. DOI: 10.1002/(Sici)1097-010X(19960415)274:6<365::Aid-Jez5>3.0.Co;2-M  0.234
2012 Aldunate R, Minniti AN, Rebolledo D, Inestrosa NC. Synaptic defects associated with s-inclusion body myositis are prevented by copper. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 25: 815-24. PMID 22573194 DOI: 10.1007/s10534-012-9553-7  0.234
2013 Oliva CA, Vargas JY, Inestrosa NC. Wnt signaling: role in LTP, neural networks and memory. Ageing Research Reviews. 12: 786-800. PMID 23665425 DOI: 10.1016/j.arr.2013.03.006  0.234
1985 Fernandez HL, Inestrosa NC, Stiles JR. Subcellular localization of acetylcholinesterase molecular forms in endplate regions of adult mammalian skeletal muscle. Neurochemical Research. 9: 1211-30. PMID 6504236 DOI: 10.1007/BF00973035  0.234
1998 Casanueva OI, Deprez P, García-Huidobro T, Inestrosa NC. At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ. Biochemical and Biophysical Research Communications. 250: 312-7. PMID 9753626 DOI: 10.1006/bbrc.1998.9303  0.231
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2021 Godoy JA, Espinoza-Caicedo J, Inestrosa NC. Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands. Cell Communication and Signaling : Ccs. 19: 87. PMID 34399774 DOI: 10.1186/s12964-021-00709-y  0.225
2010 Farías GG, Godoy JA, Cerpa W, Varela-Nallar L, Inestrosa NC. Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 94-101. PMID 19681159 DOI: 10.1002/Dvdy.22065  0.223
2018 Ramos-Fernández E, Tapia-Rojas C, Ramírez VT, Inestrosa NC. Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling. Molecular Neurobiology. PMID 29967987 DOI: 10.1007/s12035-018-1162-1  0.223
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2021 Torres VI, Barrera DP, Varas-Godoy M, Arancibia D, Inestrosa NC. Selective Surface and Intraluminal Localization of Wnt Ligands on Small Extracellular Vesicles Released by HT-22 Hippocampal Neurons. Frontiers in Cell and Developmental Biology. 9: 735888. PMID 34722516 DOI: 10.3389/fcell.2021.735888  0.22
2012 Inestrosa NC, Montecinos-Oliva C, Fuenzalida M. Wnt signaling: role in Alzheimer disease and schizophrenia. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 788-807. PMID 23160851 DOI: 10.1007/s11481-012-9417-5  0.217
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2020 Lira M, Mira RG, Carvajal FJ, Zamorano P, Inestrosa NC, Cerpa W. Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex. Cells. 9. PMID 33153008 DOI: 10.3390/cells9112402  0.217
2012 Cabeza C, Figueroa A, Lazo OM, Galleguillos C, Pissani C, Klein A, Gonzalez-Billault C, Inestrosa NC, Alvarez AR, Zanlungo S, Bronfman FC. Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease. Molecular Neurodegeneration. 7: 11. PMID 22458984 DOI: 10.1186/1750-1326-7-11  0.214
2009 Arrázola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, González M, Montecino M, Maass A, Martínez S, Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. Journal of Cellular Physiology. 221: 658-67. PMID 19711354 DOI: 10.1002/Jcp.21902  0.212
2013 Silva-Alvarez C, Arrázola MS, Godoy JA, Ordenes D, Inestrosa NC. Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics. Frontiers in Cellular Neuroscience. 7: 97. PMID 23805073 DOI: 10.3389/fncel.2013.00097  0.212
1998 Calderón FH, von Bernhardi R, De Ferrari G, Luza S, Aldunate R, Inestrosa NC. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro. Molecular Psychiatry. 3: 247-55. PMID 9672900 DOI: 10.1038/sj.mp.4000383  0.211
2010 Perez de Arce K, de Arce KP, Varela-Nallar L, Farias O, Cifuentes A, Bull P, Couch BA, Koleske AJ, Inestrosa NC, Alvarez AR. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3728-38. PMID 20220006 DOI: 10.1523/Jneurosci.2024-09.2010  0.211
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2014 Serrano FG, Tapia-Rojas C, Carvajal FJ, Hancke J, Cerpa W, Inestrosa NC. Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice. Molecular Neurodegeneration. 9: 61. PMID 25524173 DOI: 10.1186/1750-1326-9-61  0.206
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1996 Bronfman FC, Fernandez HL, Inestrosa NC. Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line. Experimental Cell Research. 229: 93-9. PMID 8940253 DOI: 10.1006/Excr.1996.0347  0.204
1984 Inestrosa NC. 16S acetylcholinesterase of the extracellular matrix is assembled within mouse muscle cells in culture. The Biochemical Journal. 217: 377-81. PMID 6696736 DOI: 10.1042/bj2170377  0.204
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2017 Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Inestrosa N, Sachdev PS. Identification Of Cerebral Metal Ion Imbalance In The Brain Of Ageing Octodon Degus: A Natural Model For Alzheimer'S Disease Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.729  0.203
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1999 Muñoz FJ, Aldunate R, Inestrosa NC. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase Neuroreport. 10: 3621-3625. PMID 10619655  0.196
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2010 Toledo EM, Inestrosa NC. Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Molecular Psychiatry. 15: 272-85, 228. PMID 19621015 DOI: 10.1038/Mp.2009.72  0.173
1983 Torres JC, Behrens MI, Inestrosa NC. Neural 16S acetylcholinesterase is solubilized by heparin. The Biochemical Journal. 215: 201-4. PMID 6626175 DOI: 10.1042/bj2150201  0.172
1989 Fadić R, Inestrosa NC. Nerve regulation of class I and class II-asymmetric forms of acetylcholinesterase in rat skeletal muscles. Journal of Neuroscience Research. 22: 449-55. PMID 2760943 DOI: 10.1002/jnr.490220410  0.172
2014 Braidy N, Brew BJ, Inestrosa NC, Chung R, Sachdev P, Guillemin GJ. Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons. Metabolic Brain Disease. 29: 873-83. PMID 24833554 DOI: 10.1007/S11011-014-9557-9  0.171
2014 Varela-Nallar L, Rojas-Abalos M, Abbott AC, Moya EA, Iturriaga R, Inestrosa NC. Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo. Frontiers in Cellular Neuroscience. 8: 17. PMID 24574965 DOI: 10.3389/fncel.2014.00017  0.17
2017 Tapia-Rojas C, Inestrosa NC. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. Journal of Neurochemistry. PMID 29240990 DOI: 10.1111/jnc.14278  0.17
2017 Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, et al. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice. Brain : a Journal of Neurology. PMID 29155979 DOI: 10.1093/Brain/Awx272  0.17
2005 Farías GG, Godoy JA, Vázquez MC, Adani R, Meshulam H, Avila J, Amitai G, Inestrosa NC. The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from β-amyloid neurotoxicity by acting on Wnt signaling components Neurobiology of Disease. 18: 176-183. PMID 15649708 DOI: 10.1016/j.nbd.2004.09.012  0.17
2015 Arrázola MS, Silva-Alvarez C, Inestrosa NC. How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario. Frontiers in Cellular Neuroscience. 9: 166. PMID 25999816 DOI: 10.3389/fncel.2015.00166  0.169
1999 Calderón FH, Bonnefont A, Muñoz FJ, Fernández V, Videla LA, Inestrosa NC. PC12 and neuro 2a cells have different susceptibilities to acetylcholinesterase-amyloid complexes, amyloid25-35 fragment, glutamate, and hydrogen peroxide. Journal of Neuroscience Research. 56: 620-31. PMID 10374817 DOI: 10.1002/(SICI)1097-4547(19990615)56:6<620::AID-JNR8>3.0.CO;2-F  0.168
2008 Cerpa W, Dinamarca MC, Inestrosa NC. Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Current Alzheimer Research. 5: 233-43. PMID 18537540 DOI: 10.2174/156720508784533321  0.168
1999 Marzolo MP, Von Bernhardi R, Inestrosa NC. Mannose receptor is present in a functional state in rat microglial cells Journal of Neuroscience Research. 58: 387-395. PMID 10518112 DOI: 10.1002/(SICI)1097-4547(19991101)58:3<387::AID-JNR4>3.0.CO;2-L  0.166
2018 Salazar P, Cisternas P, Martinez M, Inestrosa NC. Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System. Molecular Neurobiology. PMID 30073507 DOI: 10.1007/s12035-018-1270-y  0.166
2004 Farías GG, Godoy JA, Hernández F, Avila J, Fisher A, Inestrosa NC. M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway Neurobiology of Disease. 17: 337-348. PMID 15474371 DOI: 10.1016/j.nbd.2004.07.016  0.166
1983 Behrens MI, Soza MA, Inestrosa NC. Increase of muscle peroxisomal enzymes and myotonia induced by nafenopin, a hypolipidemic drug. Muscle & Nerve. 6: 154-9. PMID 6855799 DOI: 10.1002/mus.880060212  0.166
2016 Godoy JA, Lindsay CB, Quintanilla RA, Carvajal FJ, Cerpa W, Inestrosa NC. Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria. Molecular Neurobiology. PMID 27796749 DOI: 10.1007/S12035-016-0203-X  0.165
1989 Inestrosa NC, Perelman A. Distribution and anchoring of molecular forms of acetylcholinesterase. Trends in Pharmacological Sciences. 10: 325-9. PMID 2686130 DOI: 10.1016/0165-6147(89)90067-9  0.164
2011 Carvajal FJ, Inestrosa NC. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in Molecular Neuroscience. 4: 19. PMID 21949501 DOI: 10.3389/fnmol.2011.00019  0.164
2002 Garrido JL, Godoy JA, Alvarez A, Bronfman M, Inestrosa NC. Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1982-1984. PMID 12397090  0.163
2003 Deprez P, Inestrosa NC, Krejci E. Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase Journal of Biological Chemistry. 278: 23233-23242. PMID 12684510 DOI: 10.1074/jbc.M301384200  0.162
2015 Cavieres VA, González A, Muñoz VC, Yefi CP, Bustamante HA, Barraza RR, Tapia-Rojas C, Otth C, Barrera MJ, González C, Mardones GA, Inestrosa NC, Burgos PV. Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy. Plos One. 10: e0136313. PMID 26308941 DOI: 10.1371/journal.pone.0136313  0.162
2008 Inestrosa NC, Chacon M, Barria MI, Varela-Nallar L, Opazo C. Neuroprotective properties of copper binding fragments of amyloid precursor protein and prion Journal of Neurochemistry. 81: 80-80. DOI: 10.1046/J.1471-4159.81.S1.103.X  0.162
2003 De Ferrari GV, Chacón MA, Barría MI, Garrido JL, Godoy JA, Olivares G, Reyes AE, Alvarez A, Bronfman M, Inestrosa NC. Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Molecular Psychiatry. 8: 195-208. PMID 12610652 DOI: 10.1038/sj.mp.4001208  0.162
1996 Bronfman FC, Soto C, Tapia L, Tapia V, Inestrosa NC. Extracellular matrix regulates the amount of the beta-amyloid precursor protein and its amyloidogenic fragments. Journal of Cellular Physiology. 166: 360-9. PMID 8591996 DOI: 10.1002/(Sici)1097-4652(199602)166:2<360::Aid-Jcp14>3.0.Co;2-F  0.162
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2017 Zolezzi JM, Santos MJ, Bastías-Candia S, Pinto C, Godoy JA, Inestrosa NC. PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation. Biological Reviews of the Cambridge Philosophical Society. PMID 28220655 DOI: 10.1111/brv.12320  0.161
2018 Rivera DS, Lindsay CB, Codocedo JF, Carreño LE, Cabrera D, Arrese MA, Vio CP, Bozinovic F, Inestrosa NC. Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus. Molecular Neurobiology. PMID 29654490 DOI: 10.1007/s12035-018-0969-0  0.16
2017 Godoy JA, Zolezzi JM, Inestrosa NC. INT131 increases dendritic arborization and protects against Aβ toxicity by inducing mitochondrial changes in hippocampal neurons. Biochemical and Biophysical Research Communications. PMID 28655613 DOI: 10.1016/j.bbrc.2017.06.146  0.16
2010 Parodi J, Sepúlveda FJ, Roa J, Opazo C, Inestrosa NC, Aguayo LG. Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure. The Journal of Biological Chemistry. 285: 2506-14. PMID 19915004 DOI: 10.1074/jbc.M109.030023  0.159
1995 Alvarez J, Moreno RD, Inestrosa NC. Mitosis of Schwann cells and demyelination are induced by the amyloid precursor protein and other protease inhibitors in the rat sciatic nerve. The European Journal of Neuroscience. 7: 152-9. PMID 7536093 DOI: 10.1111/j.1460-9568.1995.tb01029.x  0.156
2018 Ríos JA, Godoy JA, Inestrosa NC. Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis. Cell Communication and Signaling : Ccs. 16: 15. PMID 29642895 DOI: 10.1186/s12964-018-0227-0  0.155
1997 Reyes AE, Perez DR, Alvarez A, Garrido J, Gentry MK, Doctor BP, Inestrosa NC. A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme Biochemical and Biophysical Research Communications. 232: 652-655. PMID 9126330 DOI: 10.1006/bbrc.1997.6357  0.154
2016 Guivernau B, Bonet J, Valls-Comamala V, Bosch-Morató M, Godoy JA, Inestrosa NC, Perálvarez-Marín A, Fernández-Busquets X, Andreu D, Oliva B, Muñoz FJ. Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 11693-11703. PMID 27852777 DOI: 10.1523/Jneurosci.1081-16.2016  0.153
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1996 Fernandez HL, Moreno RD, Inestrosa NC. Tetrameric (G4) acetylcholinesterase: structure, localization, and physiological regulation. Journal of Neurochemistry. 66: 1335-46. PMID 8627284 DOI: 10.1046/j.1471-4159.1996.66041335.x  0.152
1998 Moreno RD, Campos FO, Dajas F, Inestrosa NC. Developmental regulation of mouse brain monomeric acetylcholinesterase. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 16: 123-34. PMID 9762585 DOI: 10.1016/S0736-5748(98)00008-2  0.152
2016 Cisternas P, Salazar P, Silva-Álvarez C, Barros LF, Inestrosa NC. Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons. Neural Plasticity. 2016: 9839348. PMID 27688915 DOI: 10.1155/2016/9839348  0.152
2004 Fuentealba RA, Farias G, Scheu J, Bronfman M, Marzolo MP, Inestrosa NC. Signal transduction during amyloid-β-peptide neurotoxicity: Role in Alzheimer disease Brain Research Reviews. 47: 275-289. PMID 15572177 DOI: 10.1016/J.Brainresrev.2004.07.018  0.152
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2010 Griffith TN, Varela-Nallar L, Dinamarca MC, Inestrosa NC. Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Current Medicinal Chemistry. 17: 391-406. PMID 20015041 DOI: 10.2174/092986710790226156  0.15
2016 Tapia-Rojas C, Burgos PV, Inestrosa NC. Inhibition of Wnt signaling induces amyloidogenic processing of APP and the production and aggregation of Aβ42 peptides. Journal of Neurochemistry. PMID 27778356 DOI: 10.1111/jnc.13873  0.15
1984 Méndez B, Garrido J, Maldonado M, Jaksic FM, Inestrosa NC. The electric organ of Discopyge tschudii: its innervated face and the biology of acetylcholinesterase. Cellular and Molecular Neurobiology. 4: 125-42. PMID 6488242 DOI: 10.1007/Bf00711000  0.15
2012 Vergara J, Medina L, Maulén J, Inestrosa NC, Alvarez J. Nerve regeneration is improved by insulin-like growth factor I (IGF-I) and basic flbroblast growth factor (bFGF). Restorative Neurology and Neuroscience. 5: 181-9. PMID 21551900 DOI: 10.3233/RNN-1993-5302  0.15
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2021 Arredondo SB, Reyes DT, Herrera-Soto A, Mardones MD, Inestrosa NC, Varela-Nallar L. Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Scientific Reports. 11: 22904. PMID 34824314 DOI: 10.1038/s41598-021-01977-x  0.149
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2018 Cisternas P, Zolezzi JM, Martinez M, Torres VI, Wong GW, Inestrosa NC. Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease. Journal of Neurochemistry. PMID 30300917 DOI: 10.1111/jnc.14608  0.134
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1987 Inestrosa NC, Sunkel C, Arriagada J. The sensory projections of Drosophila mutants which show abnormal wing formation or flying behavior Brain Research. 416: 248-256. PMID 3113669 DOI: 10.1016/0006-8993(87)90904-8  0.131
2015 Lambert C, Cisternas P, Inestrosa NC. Role of Wnt Signaling in Central Nervous System Injury. Molecular Neurobiology. PMID 25976365 DOI: 10.1007/s12035-015-9138-x  0.13
1991 González R, Campos EO, Morán S, Inestrosa NC. Characterization of acetylcholinesterase from human heart auricles: evidence for the presence of a G-form sensitive to phosphatidylinositol-specific phospholipase c. General Pharmacology. 22: 107-10. PMID 1646743 DOI: 10.1016/0306-3623(91)90318-Z  0.13
2018 Cisternas P, Martinez M, Ahima RS, William Wong G, Inestrosa NC. Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin. Molecular Neurobiology. PMID 30076527 DOI: 10.1007/s12035-018-1271-x  0.13
1988 Fuentes ME, Rosenberry TL, Inestrosa NC. A 13 kDa fragment is responsible for the hydrophobic aggregation of brain G4 acetylcholinesterase. The Biochemical Journal. 256: 1047-50. PMID 3223943 DOI: 10.1042/bj2561047  0.13
2000 Deprez P, Inestrosa NC. Molecular modeling of the collagen-like tail of asymmetric acetylcholinesterase Protein Engineering. 13: 27-34. PMID 10679527  0.129
2013 Zolezzi JM, Silva-Alvarez C, Ordenes D, Godoy JA, Carvajal FJ, Santos MJ, Inestrosa NC. Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? Plos One. 8: e64019. PMID 23675519 DOI: 10.1371/journal.pone.0064019  0.128
2012 Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC, Palacios AG. Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 109: 13835-40. PMID 22869717 DOI: 10.1073/pnas.1201209109  0.128
2003 Chacón MA, Barría MI, Lorca R, Huidobro-Toro JP, Inestrosa NC. A human prion protein peptide (PrP(59-91)) protects against copper neurotoxicity. Molecular Psychiatry. 8: 853-62, 835. PMID 14515136 DOI: 10.1038/sj.mp.4001400  0.127
2003 Roth AD, Leisewitz AV, Jung JE, Cassina P, Barbeito L, Inestrosa NC, Bronfman M. PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. Journal of Neuroscience Research. 72: 425-35. PMID 12704804 DOI: 10.1002/Jnr.10596  0.127
2001 Morgan C, Inestrosa NC. Interactions of laminin with the amyloid ß peptide. Implications for Alzheimer's disease Brazilian Journal of Medical and Biological Research. 34: 597-601. PMID 11323745  0.127
1988 Inestrosa NC, Alvarez J. Axons grow in the aging rat but fast transport and acetylcholinesterase content remain unchanged. Brain Research. 441: 331-8. PMID 2451983 DOI: 10.1016/0006-8993(88)91411-4  0.127
2019 Toledo C, Andrade DC, Díaz HS, Inestrosa NC, Del Rio R. Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment. Molecular Neurobiology. PMID 31165973 DOI: 10.1007/s12035-019-01655-0  0.127
2015 Tapia-Rojas C, Aranguiz F, Varela-Nallar L, Inestrosa NC. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease. Brain Pathology (Zurich, Switzerland). PMID 25763997 DOI: 10.1111/bpa.12255  0.127
2008 Inestrosa NC, Dinamarca MC, Alvarez A. Amyloid-cholinesterase interactions: Implications for Alzheimer's disease Febs Journal. 275: 625-632. PMID 18205831 DOI: 10.1111/j.1742-4658.2007.06238.x  0.127
2003 Opazo C, Inés Barría M, Ruiz FH, Inestrosa NC. Copper reduction by copper binding proteins and its relation to neurodegenerative diseases Biometals. 16: 91-98. PMID 12572668 DOI: 10.1023/A:1020795422185  0.126
1995 Tapia M, Inestrosa NC, Alvarez J. Early axonal regeneration: repression by Schwann cells and a protease? Experimental Neurology. 131: 124-32. PMID 7534718 DOI: 10.1016/0014-4886(95)90014-4  0.126
2010 Varela-Nallar L, Aranguiz FC, Abbott AC, Slater PG, Inestrosa NC. Adult hippocampal neurogenesis in aging and Alzheimer's disease. Birth Defects Research. Part C, Embryo Today : Reviews. 90: 284-96. PMID 21181889 DOI: 10.1002/bdrc.20193  0.126
2015 Cuevas CA, Tapia-Rojas C, Cespedes C, Inestrosa NC, Vio CP. β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats. Biomed Research International. 2015: 726012. PMID 25945342 DOI: 10.1155/2015/726012  0.125
1982 Inestrosa NC, Fernandez HL. Gangliosides and sialoglycoproteins in normal and denervated rat diaphragm muscle. Muscle & Nerve. 5: 33-8. PMID 7057803 DOI: 10.1002/mus.880050107  0.125
1999 Inestrosa NC, Alarcón R. Molecular interactions of acetylcholinesterase with senile plaques. Journal of Physiology, Paris. 92: 341-4. PMID 9789834 DOI: 10.1016/S0928-4257(99)80002-3  0.125
2005 Inestrosa NC, Reyes AE, Chacón MA, Cerpa W, Villalón A, Montiel J, Merabachvili G, Aldunate R, Bozinovic F, Aboitiz F. Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu. Neurobiology of Aging. 26: 1023-8. PMID 15748782 DOI: 10.1016/J.Neurobiolaging.2004.09.016  0.124
2020 Rivera DS, Lindsay CB, Oliva CA, Codocedo JF, Bozinovic F, Inestrosa NC. Effects of long-lasting social isolation and re-socialization on cognitive performance and brain activity: a longitudinal study in Octodon degus. Scientific Reports. 10: 18315. PMID 33110163 DOI: 10.1038/s41598-020-75026-4  0.122
1999 Inestrosa NC, Marzolo MP, Bonnefont AB. Cellular and molecular basis of estrogen's neuroprotection. Potential relevance for Alzheimer's disease. Molecular Neurobiology. 17: 73-86. PMID 9887447 DOI: 10.1007/BF02802025  0.122
2009 Minniti AN, Cataldo R, Trigo C, Vasquez L, Mujica P, Leighton F, Inestrosa NC, Aldunate R. Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans. Aging Cell. 8: 690-705. PMID 19747232 DOI: 10.1111/j.1474-9726.2009.00521.x  0.121
2014 Zolezzi JM, Inestrosa NC. Brain metabolite clearance: impact on Alzheimer's disease. Metabolic Brain Disease. 29: 553-61. PMID 24664180 DOI: 10.1007/s11011-014-9527-2  0.121
2010 Toledo EM, Inestrosa NC. Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease Molecular Psychiatry. 15: 228. DOI: 10.1038/Mp.2010.9  0.12
1994 Inestrosa NC, Alarcón R, Arriagada J, Donoso A, Alvarez J, Campos EO. Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes. Journal of the Neurological Sciences. 122: 1-5. PMID 8195795 DOI: 10.1016/0022-510X(94)90044-2  0.12
2005 Inestrosa NC, Cerpa W, Varela-Nallar L. Copper brain homeostasis: role of amyloid precursor protein and prion protein. Iubmb Life. 57: 645-50. PMID 16203684 DOI: 10.1080/15216540500264620  0.12
2017 Zolezzi JM, Inestrosa NC. Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease. Frontiers in Immunology. 8: 187. PMID 28286503 DOI: 10.3389/fimmu.2017.00187  0.119
2016 Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Regulation of Memory Formation by the Transcription Factor XBP1. Cell Reports. PMID 26854229 DOI: 10.1016/J.Celrep.2016.01.028  0.119
1999 Bonnefont AB, Muñoz FJ, Inestrosa NC. Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase-amyloid complexes. Febs Letters. 441: 220-4. PMID 9883888 DOI: 10.1016/S0014-5793(98)01552-X  0.118
2019 Toledo C, Lucero C, Andrade DC, Díaz HS, Schwarz KG, Pereyra KV, Arce-Álvarez A, López NA, Martinez M, Inestrosa NC, Del Rio R. Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus. Aging. PMID 31447429 DOI: 10.18632/aging.102150  0.118
2006 Varela-Nallar L, Toledo EM, Chacón MA, Inestrosa NC. The functional links between prion protein and copper. Biological Research. 39: 39-44. PMID 16629163 DOI: 10.4067/S0716-97602006000100005  0.118
2013 Zolezzi JM, Carvajal FJ, Ríos JA, Ordenes D, Silva-Alvarez C, Godoy JA, Inestrosa NC. Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons. Journal of Alzheimer's Disease : Jad. 37: 735-46. PMID 23948911 DOI: 10.3233/JAD-130173  0.116
2010 Hödar C, Assar R, Colombres M, Aravena A, Pavez L, González M, Martínez S, Inestrosa NC, Maass A. Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method. Bmc Genomics. 11: 348. PMID 20515496 DOI: 10.1186/1471-2164-11-348  0.116
2022 Villaseca P, Cisternas P, Inestrosa NC. Menopause and development of Alzheimer's disease: Roles of neural glucose metabolism and Wnt signaling. Frontiers in Endocrinology. 13: 1021796. PMID 36339406 DOI: 10.3389/fendo.2022.1021796  0.116
2004 Morgan C, Colombres M, Nuñez MT, Inestrosa NC. Structure and function of amyloid in Alzheimer's disease Progress in Neurobiology. 74: 323-349. PMID 15649580 DOI: 10.1016/j.pneurobio.2004.10.004  0.115
1994 Inestrosa NC, Moreno RD, Fuentes ME. Monomeric amphiphilic forms of acetylcholinesterase appear early during brain development and may correspond to biosynthetic precursors of the amphiphilic G4 forms. Neuroscience Letters. 173: 155-8. PMID 7936404 DOI: 10.1016/0304-3940(94)90172-4  0.114
2017 Cisternas P, Inestrosa NC. Brain glucose metabolism: role of Wnt signaling in the metabolic impairment in Alzheimer's disease. Neuroscience and Biobehavioral Reviews. PMID 28624434 DOI: 10.1016/j.neubiorev.2017.06.004  0.114
1988 Fuentes ME, Inestrosa NC. Characterization of a tetrameric G4 form of acetylcholinesterase from bovine brain: a comparison with the dimeric G2 form of the electric organ. Molecular and Cellular Biochemistry. 81: 53-64. PMID 3173345 DOI: 10.1007/BF00225653  0.114
2010 Cerpa W, Hancke JL, Morazzoni P, Bombardelli E, Riva A, Marin PP, Inestrosa NC. The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model. Current Alzheimer Research. 7: 126-33. PMID 19939230 DOI: 10.2174/156720510790691218  0.114
2015 Cuevas CA, Gonzalez AA, Inestrosa NC, Vio CP, Prieto MC. Angiotensin II increases fibronectin and collagen I through the β-catenin-dependent signaling in mouse collecting duct cells. American Journal of Physiology. Renal Physiology. 308: F358-65. PMID 25411386 DOI: 10.1152/Ajprenal.00429.2014  0.113
1998 Campos EO, Alvarez A, Inestrosa NC. Brain acetylcholinesterase promotes amyloid-beta-peptide aggregation but does not hydrolyze amyloid precursor protein peptides. Neurochemical Research. 23: 135-40. PMID 9475506 DOI: 10.1023/A:1022416505725  0.113
2015 Du LY, Chang LY, Ardiles AO, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML. Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus. Plos One. 10: e0135499. PMID 26267479 DOI: 10.1371/journal.pone.0135499  0.113
2008 Rebolledo DL, Minniti AN, Grez PM, Fadic R, Kohn R, Inestrosa NC. Inclusion body myositis: a view from the Caenorhabditis elegans muscle. Molecular Neurobiology. 38: 178-98. PMID 18773311 DOI: 10.1007/s12035-008-8041-0  0.113
2009 Inestrosa NC, Grabowski C, Arrázola M, Varela-Nallar L, Toledo EM. Role of Alzheimer's β-Amyloid on Wnt signaling Protein Misfolding Disorders: a Trip Into the Er. 103-113. DOI: 10.2174/978160805013010901010103  0.112
1994 Soto C, Brañes MC, Alvarez J, Inestrosa NC. Structural determinants of the Alzheimer's amyloid beta-peptide. Journal of Neurochemistry. 63: 1191-8. PMID 7931272 DOI: 10.1046/j.1471-4159.1994.63041191.x  0.112
2001 De Ferrari GV, Canales MA, Shin I, Weiner LM, Silman I, Inestrosa NC. A structural motif of acetylcholinesterase that promotes amyloid beta-peptide fibril formation. Biochemistry. 40: 10447-57. PMID 11523986 DOI: 10.1021/Bi0101392  0.11
2000 Ruiz FH, Silva E, Inestrosa NC. The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues Biochemical and Biophysical Research Communications. 269: 491-495. PMID 10708581 DOI: 10.1006/bbrc.2000.2270  0.11
1996 Bronfman FC, Garrido J, Alvarez A, Morgan C, Inestrosa NC. Laminin inhibits amyloid-beta-peptide fibrillation. Neuroscience Letters. 218: 201-3. PMID 8945763 DOI: 10.1016/S0304-3940(96)13147-5  0.109
1997 Alvarez A, Opazo C, Alarcón R, Garrido J, Inestrosa NC. Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils. Journal of Molecular Biology. 272: 348-61. PMID 9325095 DOI: 10.1006/jmbi.1997.1245  0.109
2006 Dinamarca MC, Cerpa W, Garrido J, Hancke JL, Inestrosa NC. Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits. Molecular Psychiatry. 11: 1032-48. PMID 16880827 DOI: 10.1038/sj.mp.4001866  0.108
1989 Inestrosa NC, Cross D. Expression of size-selected messenger RNA encoding the brain and adrenal gland angiotensin-II receptor in Xenopus laevis oocytes. Archivos De Biologia Y Medicina Experimentales. 21: 423-8. PMID 3256274  0.108
2008 Dinamarca MC, Arrázola M, Toledo E, Cerpa WF, Hancke J, Inestrosa NC. Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. Chemico-Biological Interactions. 175: 142-9. PMID 18599028 DOI: 10.1016/J.Cbi.2008.05.026  0.107
2018 Godoy JA, Valdivieso AG, Inestrosa NC. Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons. Molecular Neurobiology. PMID 29619740 DOI: 10.1007/s12035-018-1034-8  0.107
1999 Muñoz FJ, Inestrosa NC. Neurotoxicity of acetylcholinesterase amyloid beta-peptide aggregates is dependent on the type of Abeta peptide and the AChE concentration present in the complexes. Febs Letters. 450: 205-9. PMID 10359075 DOI: 10.1016/S0014-5793(99)00468-8  0.106
2004 Doss-Pepe E, Deprez P, Silva T, Inestrosa NC, Kirkpatrick A, Ramshaw JAM, Brodsky B. Stepwise construction of triple-helical heparin binding sites using peptide models Biochimica Et Biophysica Acta - Proteins and Proteomics. 1698: 187-195. PMID 15134651 DOI: 10.1016/j.bbapap.2003.11.034  0.106
1986 Fiedler JL, Inestrosa NC, Bustos G. Putative glutamate receptors in membranes obtained from heads of Drosophila melanogaster. Journal of Neuroscience Research. 16: 505-15. PMID 2877097 DOI: 10.1002/jnr.490160306  0.106
1998 Bronfman FC, Alvarez A, Morgan C, Inestrosa NC. Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 5: 16-23. PMID 9547001 DOI: 10.3109/13506129809007285  0.106
2002 Muñoz FJ, Opazo C, Gil-Gómez G, Tapia G, Fernández V, Valverde MA, Inestrosa NC. Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3081-9. PMID 11943811  0.105
2009 Minniti AN, Rebolledo DL, Grez PM, Fadic R, Aldunate R, Volitakis I, Cherny RA, Opazo C, Masters C, Bush AI, Inestrosa NC. Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification. Molecular Neurodegeneration. 4: 2. PMID 19126228 DOI: 10.1186/1750-1326-4-2  0.104
1995 Inestrosa NC, Soto C. Molecular biology of the amyloid of Alzheimer's disease. An overview. Biological Research. 25: 63-72. PMID 1365703  0.103
2022 Novoa C, Salazar P, Cisternas P, Gherardelli C, Vera-Salazar R, Zolezzi JM, Inestrosa NC. Inflammation context in Alzheimer's disease, a relationship intricate to define. Biological Research. 55: 39. PMID 36550479 DOI: 10.1186/s40659-022-00404-3  0.103
2000 Opazo C, Ruiz FH, Inestrosa NC. Amyloid-β-peptide reduces copper(II) to copper(I) independent of its aggregation state Biological Research. 33: 125-131. PMID 15693279  0.103
2016 Estrada LD, Chamorro D, Yañez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR. Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition. Journal of Alzheimer's Disease : Jad. PMID 27567806 DOI: 10.3233/Jad-151087  0.103
2015 Cisternas P, Lindsay CB, Salazar P, Silva-Alvarez C, Retamales RM, Serrano FG, Vio CP, Inestrosa NC. The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease. Biochimica Et Biophysica Acta. 1852: 2630-44. PMID 26391254 DOI: 10.1016/j.bbadis.2015.09.009  0.102
2000 Deprez P, Doss-Pepe E, Brodsky B, Inestrosa NC. Interaction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability Biochemical Journal. 350: 283-290. PMID 10926855 DOI: 10.1042/0264-6021:3500283  0.102
2014 Ríos JA, Cisternas P, Arrese M, Barja S, Inestrosa NC. Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum. Progress in Neurobiology. 121: 125-46. PMID 25084549 DOI: 10.1016/j.pneurobio.2014.07.004  0.102
2021 Cisternas P, Gherardelli C, Salazar P, Inestrosa NC. Disruption of Glucose Metabolism in Aged : A Sporadic Model of Alzheimer's Disease. Frontiers in Integrative Neuroscience. 15: 733007. PMID 34707484 DOI: 10.3389/fnint.2021.733007  0.102
2015 Bravo-Zehnder M, Toledo EM, Segovia-Miranda F, Serrano FG, Benito MJ, Metz C, Retamal C, Álvarez A, Massardo L, Inestrosa NC, González A. Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis & Rheumatology (Hoboken, N.J.). 67: 204-14. PMID 25302407 DOI: 10.1002/Art.38900  0.101
2004 Chacón MA, Barría MI, Soto C, Inestrosa NC. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits. Molecular Psychiatry. 9: 953-61. PMID 15098004 DOI: 10.1038/Sj.Mp.4001516  0.1
1980 Inestrosa NC, Bronfman M, Leighton F. Detection of peroxisomal fatty acyl-coenzyme A oxidase activity. The Biochemical Journal. 182: 779-88. PMID 518563 DOI: 10.1042/bj1820779  0.1
2019 Lindsay CB, Zolezzi JM, Rivera DS, Cisternas P, Bozinovic F, Inestrosa NC. Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus. Molecular Neurobiology. PMID 31701436 DOI: 10.1007/s12035-019-01784-6  0.099
2022 Gherardelli C, Cisternas P, Inestrosa NC. Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer's Disease. International Journal of Molecular Sciences. 23. PMID 35955868 DOI: 10.3390/ijms23158733  0.099
2023 Braidy N, Brew BJ, Inestrosa NC, Chung R, Sachdev P, Guillemin GJ. Retraction Note to: Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons. Metabolic Brain Disease. PMID 37273082 DOI: 10.1007/s11011-023-01241-3  0.098
2014 Inestrosa NC, Ríos JA, Cisternas P, Tapia-Rojas C, Rivera DS, Braidy N, Zolezzi JM, Godoy JA, Carvajal FJ, Ardiles AO, Bozinovic F, Palacios AG, Sachdev PS. Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease. Brain Pathology (Zurich, Switzerland). PMID 25351914 DOI: 10.1111/Bpa.12226  0.098
2000 Doss-Pepe E, Deprez P, Inestrosa NC, Brodsky B. Interaction of collagen-like peptide models of asymmetric acetylcholinesterase with glycosaminoglycans: Spectroscopic studies of conformational changes and stability Biochemistry. 39: 14884-14892. PMID 11101304 DOI: 10.1021/bi001108u  0.098
2023 Cisternas P, Gherardelli C, Gutierrez J, Salazar P, Mendez-Orellana C, Wong GW, Inestrosa NC. Adiponectin and resistin modulate the progression of Alzheimer´s disease in a metabolic syndrome model. Frontiers in Endocrinology. 14: 1237796. PMID 37732123 DOI: 10.3389/fendo.2023.1237796  0.098
2005 Cerpa W, Varela-Nallar L, Reyes AE, Minniti AN, Inestrosa NC. Is there a role for copper in neurodegenerative diseases? Molecular Aspects of Medicine. 26: 405-20. PMID 16112188 DOI: 10.1016/J.Mam.2005.07.011  0.097
2015 Retamales-Ortega R, Vio CP, Inestrosa NC. P2C-Type ATPases and Their Regulation. Molecular Neurobiology. PMID 25631710 DOI: 10.1007/s12035-014-9076-z  0.097
2018 Cisternas P, Zolezzi JM, Lindsay C, Rivera DS, Martinez A, Bozinovic F, Inestrosa NC. New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-β Peptide Aggregation and Age-Related Amyloid Pathology. Journal of Alzheimer's Disease : Jad. PMID 30412496 DOI: 10.3233/JAD-180729  0.096
2015 Minniti AN, Arrazola MS, Bravo-Zehnder M, Ramos F, Inestrosa NC, Aldunate R. The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Aβ aggregation and toxicity in vivo. Antioxidants & Redox Signaling. 22: 48-62. PMID 24988428 DOI: 10.1089/ars.2013.5803  0.096
2006 Varela-Nallar L, González A, Inestrosa NC. Role of copper in prion diseases: Deleterious or beneficial? Current Pharmaceutical Design. 12: 2587-2595. PMID 16842180 DOI: 10.2174/138161206777698873  0.096
2012 Braidy N, Muñoz P, Palacios AG, Castellano-Gonzalez G, Inestrosa NC, Chung RS, Sachdev P, Guillemin GJ. Recent rodent models for Alzheimer's disease: clinical implications and basic research. Journal of Neural Transmission (Vienna, Austria : 1996). 119: 173-95. PMID 22086139 DOI: 10.1007/S00702-011-0731-5  0.096
2016 Cuevas CA, Tapia-Rojas C, Cespedes C, Inestrosa NC, Vio CP. Corrigendum to "β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats". Biomed Research International. 2016: 9672429. PMID 27803932 DOI: 10.1155/2016/9672429  0.095
1988 Cross D, Cifuentes F, Huidobro-Toro JP, Vío CP, Inestrosa NC. Synthesis and expression of functional angiotensin II receptors in Xenopus oocytes injected with rat brain mRNA. Brain Research. 388: 268-70. PMID 3676711 DOI: 10.1016/0169-328X(87)90034-9  0.095
2015 Lambert C, Cisternas P, Inestrosa NC. Role of Wnt Signaling in Central Nervous System Injury Molecular Neurobiology. DOI: 10.1007/s12035-015-9138-x  0.093
2017 Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Jugder BE, Jayasena T, Inestrosa NC, Sachdev PS. Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus. Frontiers in Aging Neuroscience. 9: 66. PMID 28405187 DOI: 10.3389/Fnagi.2017.00066  0.093
2023 Martinez A, Lamaizon CM, Valls C, Llambi F, Leal N, Fitzgerald P, Guy C, Kamiński MM, Inestrosa NC, van Zundert B, Cancino GI, Dulcey AE, Zanlungo S, Marugan JJ, Hetz C, et al. c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration. Antioxidants (Basel, Switzerland). 12. PMID 38001860 DOI: 10.3390/antiox12112007  0.093
2020 Gherardelli C, Cisternas P, Gutiérrez J, Martinez M, Inestrosa NC. Andrographolide restores glucose uptake in rat hippocampal neurons. Journal of Neurochemistry. PMID 33124061 DOI: 10.1111/jnc.15229  0.092
2014 Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Jayasena T, Inestrosa NC, Sachdev P. Metal and complementary molecular bioimaging in Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 138. PMID 25076902 DOI: 10.3389/Fnagi.2014.00138  0.091
2009 Vázquez MC, Vargas LM, Inestrosa NC, Alvarez AR. c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis. Journal of Cellular Physiology. 220: 136-43. PMID 19306298 DOI: 10.1002/jcp.21743  0.09
1998 Deprez P, Krejci E, Massoulié J, Inestrosa N. 26 Dissection of the heparin-binding domains present in the collagenic tail of mammalian acetylcholinesterase Journal of Physiology-Paris. 92: 425-426. DOI: 10.1016/S0928-4257(99)80038-2  0.09
2002 Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). The Journal of Biological Chemistry. 277: 40302-8. PMID 12192006 DOI: 10.1074/Jbc.M206428200  0.089
1995 Soto C, Castaño EM, Frangione B, Inestrosa NC. The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation. The Journal of Biological Chemistry. 270: 3063-7. PMID 7852387 DOI: 10.1074/jbc.270.7.3063  0.087
1998 Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils The Journal of Neuroscience. 18: 3213-3223. DOI: 10.1523/JNEUROSCI.18-09-03213.1998  0.086
1993 Gonzalez RA, Campos EO, Karmelic C, Moran S, Inestrosa NC. Acetylcholinesterase changes in hearts with sinus rhythm and atrial fibrillation. General Pharmacology. 24: 111-4. PMID 8482484 DOI: 10.1016/0306-3623(93)90019-T  0.085
1985 Bronfman M, Inestrosa NC, Nervi FO, Leighton F. Acyl-CoA synthetase and the peroxisomal enzymes of beta-oxidation in human liver. Quantitative analysis of their subcellular localization. The Biochemical Journal. 224: 709-20. PMID 6240978 DOI: 10.1042/bj2240709  0.084
2015 Braidy N, Poljak A, Jayasena T, Mansour H, Inestrosa NC, Sachdev PS. Accelerating Alzheimer's research through 'natural' animal models. Current Opinion in Psychiatry. 28: 155-64. PMID 25602247 DOI: 10.1097/Yco.0000000000000137  0.083
2006 Inestrosa NC, Farías G, Colombres M. Glycogen Synthase Kinase 3β (GSK-3β) a Key Signaling Enzyme: A Developmental Neurobiological Perspective Glycogen Synthase Kinase 3 (Gsk-3) and Its Inhibitors: Drug Discovery and Development. 25-43. DOI: 10.1002/9780470052174.ch2  0.082
2023 Schwarz KG, Vicencio SC, Inestrosa NC, Villaseca P, Del Rio R. Autonomic nervous system dysfunction throughout menopausal transition: A potential mechanism underpinning cardiovascular and cognitive alterations during female ageing. The Journal of Physiology. 602: 263-280. PMID 38064358 DOI: 10.1113/JP285126  0.082
2021 Carreño DV, Corro NB, Cerda-Infante JF, Echeverría CE, Asencio-Barría CA, Torres-Estay VA, Mayorga-Weber GA, Rojas PA, Véliz LP, Cisternas PA, Montecinos VP, San Francisco IF, Varas-Godoy MA, Sotomayor PC, Castro MA, ... ... Inestrosa NC, et al. Dietary Fructose Promotes Prostate Cancer Growth. Cancer Research. PMID 33762358 DOI: 10.1158/0008-5472.CAN-19-0456  0.081
1998 Opazo C, Inestrosa NC. Crosslinking of amyloid-beta peptide to brain acetylcholinesterase. Molecular and Chemical Neuropathology. 33: 39-49. PMID 9493175 DOI: 10.1007/BF02815858  0.081
2023 Oliva CA, Lira M, Jara C, Catenaccio A, Mariqueo TA, Lindsay CB, Bozinovic F, Cavieres G, Inestrosa NC, Tapia-Rojas C, Rivera DS. Long-term social isolation stress exacerbates sex-specific neurodegeneration markers in a natural model of Alzheimer's disease. Frontiers in Aging Neuroscience. 15: 1250342. PMID 37810621 DOI: 10.3389/fnagi.2023.1250342  0.081
1999 Contreras CF, Canales MA, Alvarez A, De Ferrari GV, Inestrosa NC. Molecular modeling of the amyloid-β-peptide using the homology to a fragment of triosephosphate isomerase that forms amyloid in vitro Protein Engineering. 12: 959-966. PMID 10585501  0.081
2016 González A, Cavieres VA, Inestrosa NC, Burgos PV. Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: potential mechanism for Alzheimer's disease therapy. Neural Regeneration Research. 11: 242-3. PMID 27073374 DOI: 10.4103/1673-5374.177728  0.081
2009 Suazo M, Hodar C, Morgan C, Cerpa W, Cambiazo V, Inestrosa NC, Gonzalez M. Overexpression of amyloid precursor protein increases copper content in HEK293 cells. Biochemical and Biophysical Research Communications. 382: 740-4. PMID 19318086 DOI: 10.1016/J.Bbrc.2009.03.096  0.079
2022 Mello-Carpes PB, Inestrosa NC, Paula-Lima AC. Editorial: Molecular mechanisms of Alzheimer's disease: From top to bottom. Frontiers in Aging. 3: 1026942. PMID 36187848 DOI: 10.3389/fragi.2022.1026942  0.076
2015 Du LY, Chang LYL, Ardiles A, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML. Alzheimer's disease-related protein expression in the retina of Octodon degus Plos One. 10. DOI: 10.1371/journal.pone.0135499  0.075
2022 Gherardelli C, Cisternas P, Vera-Salazar RF, Mendez-Orellana C, Inestrosa NC. Age- and Sex-Associated Glucose Metabolism Decline in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 35404275 DOI: 10.3233/JAD-215273  0.075
2001 De Ferrari GV, Mallender WD, Inestrosa NC, Rosenberry TL. Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites Journal of Biological Chemistry. 276: 23282-23287. PMID 11313335 DOI: 10.1074/jbc.M009596200  0.075
1996 Inestrosa NC, Sunkel CE, Arriagada J, Garrido J, Godoy-Herrera R. Abnormal development of the locomotor activity in yellow larvae of Drosophila: a cuticular defect? Genetica. 97: 205-10. PMID 8901139 DOI: 10.1007/Bf00054627  0.074
1997 Inestrosa NC, Alvarez A, Calderón F. Acetylcholinesterase is a senile plaque component that promotes assembly of amyloid beta-peptide into Alzheimer's filaments. Molecular Psychiatry. 1: 359-61. PMID 9154226  0.074
2015 Arrázola MS, Inestrosa NC. Monitoring mitochondrial membranes permeability in live neurons and mitochondrial swelling through electron microscopy analysis. Methods in Molecular Biology (Clifton, N.J.). 1254: 87-97. PMID 25431059 DOI: 10.1007/978-1-4939-2152-2_7  0.073
1995 Alvarez A, Bronfman F, Pérez CA, Vicente M, Garrido J, Inestrosa NC. Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-β-peptides Neuroscience Letters. 201: 49-52. PMID 8830310 DOI: 10.1016/0304-3940(94)12127-C  0.073
2005 Von Bernhardi R, Alarcón R, Mezzano D, Fuentes P, Inestrosa NC. Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia Dementia and Geriatric Cognitive Disorders. 19: 204-212. PMID 15677868 DOI: 10.1159/000083500  0.072
2012 Assar R, Leisewitz AV, Garcia A, Inestrosa NC, Montecino MA, Sherman DJ. Reusing and composing models of cell fate regulation of human bone precursor cells. Bio Systems. 108: 63-72. PMID 22309764 DOI: 10.1016/j.biosystems.2012.01.008  0.07
1995 Chen M, Inestrosa NC, Ross GS, Fernandez HL. Platelets are the primary source of amyloid beta-peptide in human blood. Biochemical and Biophysical Research Communications. 213: 96-103. PMID 7639768 DOI: 10.1006/bbrc.1995.2103  0.069
2015 Codocedo JF, Ríos JA, Godoy JA, Inestrosa NC. Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease? Molecular Neurobiology. PMID 25976367 DOI: 10.1007/s12035-015-9201-7  0.068
1990 Inestrosa NC, Perelman A. Association of acetylcholinesterase with the cell surface. The Journal of Membrane Biology. 118: 1-9. PMID 2283677 DOI: 10.1007/BF01872200  0.066
1999 Ruiz FH, González M, Bodini M, Opazo C, Inestrosa NC. Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein. Journal of Neurochemistry. 73: 1288-92. PMID 10461923 DOI: 10.1046/j.1471-4159.1999.0731288.x  0.066
2021 Schwarz KG, Pereyra KV, Toledo C, Andrade DC, Díaz HS, Díaz-Jara E, Ortolani D, Rios-Gallardo A, Arias P, Las Heras A, Vera I, Ortiz FC, Inestrosa NC, Vio CP, Del Rio R. Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure. Biological Research. 54: 43. PMID 34952651 DOI: 10.1186/s40659-021-00365-z  0.066
2016 Rivera DS, Inestrosa NC, Bozinovic F. On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae). Biological Research. 49: 10. PMID 26897365 DOI: 10.1186/s40659-016-0074-7  0.065
2018 Carreño D, Corro N, Torres-Estay V, Véliz LP, Jaimovich R, Cisternas P, San Francisco IF, Sotomayor PC, Tanasova M, Inestrosa NC, Godoy AS. Fructose and prostate cancer: toward an integrated view of cancer cell metabolism. Prostate Cancer and Prostatic Diseases. PMID 30104655 DOI: 10.1038/S41391-018-0072-7  0.064
2019 Zolezzi JM, Inestrosa NC. Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration. Neural Regeneration Research. 14: 1705-1706. PMID 31169181 DOI: 10.4103/1673-5374.257521  0.061
1980 Inestrosa NC, Bronfman M, Leighton F. Purification of the peroxisomal fatty acyl-CoA oxidase from rat liver. Biochemical and Biophysical Research Communications. 95: 7-12. PMID 7417271 DOI: 10.1016/0006-291X(80)90696-8  0.06
2015 Montecinos-Oliva C, Tapia-Rojas C, Burgos PV, Inestrosa NC. New discoveries on the hyperforin derivative, tetrahydrohyperforin: Closer to an Alzheimer'S disease treatment? Hypericum: Botanical Sources, Medical Properties and Health Effects. 119-137.  0.059
2021 Rivera DS, Lindsay CB, Oliva CA, Bozinovic F, Inestrosa NC. A Multivariate Assessment of Age-Related Cognitive Impairment in . Frontiers in Integrative Neuroscience. 15: 719076. PMID 34526882 DOI: 10.3389/fnint.2021.719076  0.058
2004 Cerpa WF, Barría MI, Chacón MA, Suazo M, González M, Opazo C, Bush AI, Inestrosa NC. The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1701-3. PMID 15345692 DOI: 10.1096/Fj.03-1349Fje  0.057
1994 Inestrosa NC, Alarcón R, Arriagada J, Donoso A, Alvarez J. Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine. Neuroscience Letters. 163: 8-10. PMID 8295739 DOI: 10.1016/0304-3940(93)90216-8  0.057
1980 Inestrosa NC, Bronfman M, Leighton F. Properties of fatty acyl-CoA oxidase from rat liver, a peroxisomal flavoprotein. Life Sciences. 25: 1127-35. PMID 513950 DOI: 10.1016/0024-3205(79)90134-6  0.057
2021 Rivera DS, Lindsay CB, Oliva CA, Bozinovic F, Inestrosa NC. "Live together, die alone": The effect of re-socialization on behavioural performance and social-affective brain-related proteins after a long-term chronic social isolation stress. Neurobiology of Stress. 14: 100289. PMID 33426200 DOI: 10.1016/j.ynstr.2020.100289  0.055
2015 Montecinos-Oliva C, Schüller A, Inestrosa NC. Tetrahydrohyperforin: a neuroprotective modified natural compound against Alzheimer's disease. Neural Regeneration Research. 10: 552-4. PMID 26170810 DOI: 10.4103/1673-5374.155420  0.054
1998 Pérez D, Alarcón R, Inestrosa N. Kinetic and thermodynamic effects of acetylcholinesterase on the solubility of Aβ peptide Journal of Physiology-Paris. 92: 479. DOI: 10.1016/S0928-4257(99)80095-3  0.054
2023 Allendes FJ, Díaz HS, Ortiz FC, Marcus NJ, Quintanilla R, Inestrosa NC, Del Rio R. Cardiovascular and autonomic dysfunction in long-COVID syndrome and the potential role of non-invasive therapeutic strategies on cardiovascular outcomes. Frontiers in Medicine. 9: 1095249. PMID 36743679 DOI: 10.3389/fmed.2022.1095249  0.051
2008 Simonetta SH, Romanowski A, Minniti AN, Inestrosa NC, Golombek DA. Circadian stress tolerance in adult Caenorhabditis elegans. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 194: 821-8. PMID 18648821 DOI: 10.1007/S00359-008-0353-Z  0.05
2021 Salazar P, Villaseca P, Cisternas P, Inestrosa NC. Neurodevelopmental impact of the offspring by thyroid hormone system-disrupting environmental chemicals during pregnancy. Environmental Research. 200: 111345. PMID 34087190 DOI: 10.1016/j.envres.2021.111345  0.049
2018 Bastías-Candia S, Zolezzi JM, Inestrosa NC. Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model. Molecular Neurobiology. PMID 29862459 DOI: 10.1007/s12035-018-1148-z  0.048
2003 Chacón MA, Barría MI, Lorca R, Huidobro-Toro JP, Inestrosa NC. A human prion protein peptide (PrP59-91) protects against copper neurotoxicity Molecular Psychiatry. 8: 835+833.  0.045
2020 Del Rio R, Marcus NJ, Inestrosa NC. Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality. Frontiers in Physiology. 11: 561749. PMID 33178034 DOI: 10.3389/fphys.2020.561749  0.04
2015 Codocedo JF, Inestrosa NC. Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior. Neuroscience and Biobehavioral Reviews. PMID 26593111 DOI: 10.1016/j.neubiorev.2015.10.010  0.039
1979 Bronfman M, Inestrosa NC, Leighton F. Fatty acid oxidation by human liver peroxisomes. Biochemical and Biophysical Research Communications. 88: 1030-6. PMID 465070 DOI: 10.1016/0006-291X(79)91512-2  0.026
1997 Martínez G, Muñoz GA, Campos EO, Inestrosa NC. Cyclic AMP and the reproductive process of the scallopArgopecten purpuratus The Journal of Experimental Zoology. 278: 243-249. DOI: 10.1002/(SICI)1097-010X(19970701)278:4<243::AID-JEZ5>3.0.CO;2-P  0.024
2017 Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Jugder BE, Jayasena T, Inestrosa NC, Sachdev PS. Corrigendum: Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus. Frontiers in Aging Neuroscience. 9: 134. PMID 28515691 DOI: 10.3389/Fnagi.2017.00134  0.022
2022 Schwarz KG, Pereyra KV, Toledo C, Andrade DC, Díaz HS, Díaz-Jara E, Ortolani D, Rios-Gallardo A, Arias P, Heras AL, Vera I, Ortiz FC, Inestrosa NC, Vio CP, Del Rio R. Correction to: Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure. Biological Research. 55: 3. PMID 35063041 DOI: 10.1186/s40659-022-00370-w  0.022
2016 Inestrosa NC, Santos MJ. Special series on trending themes in Neurobiology in Biological Research. Biological Research. 49: 19. PMID 26988549 DOI: 10.1186/s40659-016-0077-4  0.01
2011 Gonzalez-Billaul C, Inestrosa NC, Santos MJ. Contributions by researchers of "Ciencia de Frontera" of the Chilean Academy of Sciences. Biological Research. 44: 5. PMID 21720675  0.01
2006 Inestrosa N. Demencias: ¿qué hay de nuevo? avances en la neurobiología de la enfermedad de Alzheimer Medwave. 6. DOI: 10.5867/medwave.2006.02.1142  0.01
2004 Inestrosa NC. [Dr. Joaquín Luco Valenzuela. 1913-2002]. Biological Research. 36: 143-6. PMID 14513709  0.01
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