Randy D. Blakely - Publications

Vanderbilt University, Nashville, TN 
 Florida Atlantic University, Boca Raton, FL, United States 
 Emory University, Atlanta, GA 
Neuroscience, Pharmacology, Genetics, Presynaptic plasma membrane transporter

313 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Donovan E, Avila C, Klausner S, Parikh V, Fenollar-Ferrer C, Blakely RD, Sarter M. Disrupted choline clearance and sustained acetylcholine release by a common choline transporter coding variant associated with poor attentional control in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 35232764 DOI: 10.1523/JNEUROSCI.1334-21.2022  0.323
2021 Refai O, Aggarwal S, Cheng MH, Gichi Z, Salvino JM, Bahar I, Blakely RD, Mortensen OV. Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in C. elegans through Interactions with the Dopamine Transporter DAT-1. Molecular Pharmacology. PMID 34906999 DOI: 10.1124/molpharm.121.000400  0.754
2021 Ren J, Lu X, Hall G, Privratsky JR, Robson MJ, Blakely RD, Crowley SD. IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage. American Journal of Physiology. Renal Physiology. PMID 34894725 DOI: 10.1152/ajprenal.00353.2021  0.546
2021 Stilley SE, Blakely RD. Rare Opportunities for Insights Into Serotonergic Contributions to Brain and Bowel Disorders: Studies of the SERT Ala56 Mouse. Frontiers in Cellular Neuroscience. 15: 677563. PMID 34149362 DOI: 10.3389/fncel.2021.677563  0.352
2021 Meinke C, Quinlan MA, Paffenroth KC, Harrison FE, Fenollar-Ferrer C, Katamish RM, Stillman I, Ramamoorthy S, Blakely RD. Serotonin Transporter Ala276 Mouse: Novel Model to Assess the Neurochemical and Behavioral Impact of Thr276 Phosphorylation In Vivo. Neurochemical Research. PMID 33830406 DOI: 10.1007/s11064-021-03299-w  0.357
2021 O'Reilly KC, Connor M, Pierson J, Shuffrey LC, Blakely RD, Ahmari SE, Veenstra-VanderWeele J. Serotonin 5-HT receptor-mediated behavior and binding in mice with the overactive and dysregulated serotonin transporter Ala56 variant. Psychopharmacology. PMID 33511450 DOI: 10.1007/s00213-020-05758-8  0.598
2020 Mayer FP, Iwamoto H, Hahn MK, Grumbar GJ, Stewart A, Li Y, Blakely RD. There's No Place Like Home? Return to the Home Cage Triggers Dopamine Release in the Mouse Nucleus Accumbens. Neurochemistry International. 104894. PMID 33161093 DOI: 10.1016/j.neuint.2020.104894  0.668
2020 Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, Pendry RJ, Tan T, Ellegood J, Albert Basson M, Blakely RD, et al. Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits. Nature Neuroscience. PMID 32661395 DOI: 10.1038/S41593-020-0665-Z  0.672
2020 Quinlan MA, Robson MJ, Ye R, Rose KL, Schey KL, Blakely RD. Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Frontiers in Molecular Neuroscience. 13: 89. PMID 32581705 DOI: 10.3389/Fnmol.2020.00089  0.706
2020 O'Reilly KC, Anacker AMJ, Rogers TD, Forsberg CG, Wang J, Zhang B, Blakely RD, Veenstra-VanderWeele J. A social encounter drives gene expression changes linked to neuronal function, brain development, and related disorders in mice expressing the serotonin transporter Ala56 variant. Neuroscience Letters. 135027. PMID 32437898 DOI: 10.1016/J.Neulet.2020.135027  0.628
2020 Areal LB, Blakely RD. Neurobehavioral changes arising from early life dopamine signaling perturbations. Neurochemistry International. 137: 104747. PMID 32325191 DOI: 10.1016/j.neuint.2020.104747  0.352
2019 Robinson SB, Refai O, Hardaway JA, Sturgeon S, Popay T, Bermingham DP, Freeman P, Wright J, Blakely RD. Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1. Plos One. 14: e0216417. PMID 31083672 DOI: 10.1371/journal.pone.0216417  0.781
2019 Koshy Cherian A, Tronson NC, Parikh V, Kucinski A, Blakely RD, Sarter M. Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice. Behavioral Neuroscience. PMID 30896190 DOI: 10.1037/bne0000310  0.311
2019 Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, ... Blakely RD, et al. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. 50: 764-766. PMID 30893590 DOI: 10.1016/J.Immuni.2019.02.012  0.607
2019 Simmler LD, Blakely RD. The SERT Met172 Mouse: An Engineered Model to Elucidate the Contributions of Serotonin Signaling to Cocaine Action. Acs Chemical Neuroscience. PMID 30817127 DOI: 10.1021/acschemneuro.9b00005  0.396
2019 Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, ... Blakely RD, et al. Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity. PMID 30683620 DOI: 10.1016/J.Immuni.2018.12.012  0.594
2019 Quinlan MA, Krout D, Katamish R, Robson MJ, Nettesheim C, Gresch PJ, Mash D, Henry K, Blakely RD. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. Acs Chemical Neuroscience. PMID 30668912 DOI: 10.1021/Acschemneuro.8B00689  0.719
2019 Brindley RL, Beth Bauer M, Walker LA, Quinlan MA, Carneiro AM, Sze J, Blakely RD, Currie KP. Conditional Knockout of the Serotonin Transporter (SERT) Demonstrates Its Role in Accumulating and Maintaining 5-HT Homeostasis in the Sympathoadrenal System Biophysical Journal. 116: 524a. DOI: 10.1016/j.bpj.2018.11.2823  0.444
2019 Liu X, Nemeth D, McKim D, Zhu L, DiSabato D, Berdysz O, Gorantla G, Oliver B, Witcher K, Wang Y, Sheridan J, Godbout J, Robson M, Blakely R, Popovich P, et al. Abstract # 2075 Structural and functional cytoarchitecture of IL-1R1-expressing system in the brain Brain Behavior and Immunity. 76. DOI: 10.1016/J.Bbi.2018.11.201  0.582
2019 Baganz N, Smith J, Harbom L, Castriz E, Robson M, Blakely R. Abstract # 2043 Contributions of inflammatory cytokine signaling to the enduring effects of early-life stress: A serotonin connection? Brain, Behavior, and Immunity. 76: e2. DOI: 10.1016/J.Bbi.2018.11.176  0.635
2018 Stewart A, Davis GL, Gresch PJ, Katamish RM, Peart R, Rabil MJ, Gowrishankar R, Carroll FI, Hahn MK, Blakely RD. Serotonin transporter inhibition and 5-HT receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30578419 DOI: 10.1038/s41386-018-0301-8  0.734
2018 Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, Watterson DM, Blakely RD. p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proceedings of the National Academy of Sciences of the United States of America. PMID 30297392 DOI: 10.1073/Pnas.1809137115  0.761
2018 Thal LB, Tomlinson ID, Quinlan MA, Kovtun O, Blakely RD, Rosenthal SJ. Single quantum dot imaging reveals PKCβ-dependent alterations in membrane diffusion and clustering of an ADHD/autism/bipolar disorder-associated dopamine transporter variant. Acs Chemical Neuroscience. PMID 30153408 DOI: 10.1021/Acschemneuro.8B00350  0.414
2018 Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ. Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation. Molecular Metabolism. PMID 29914854 DOI: 10.1016/J.Molmet.2018.06.003  0.583
2018 Brindley RL, Bauer MB, Walker LA, Quinlan MA, Carneiro AMD, Sze JY, Blakely RD, Currie KPM. Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter. Pharmacological Research. PMID 29894763 DOI: 10.1016/j.phrs.2018.06.008  0.434
2018 Refai O, Blakely RD. Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone. Neurochemistry International. PMID 29800604 DOI: 10.1016/j.neuint.2018.05.013  0.417
2018 Gowrishankar R, Gresch PJ, Davis GL, Katamish RM, Riele JR, Stewart AM, Vaughan RA, Hahn MK, Blakely RD. Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29739866 DOI: 10.1523/Jneurosci.0055-18.2018  0.737
2018 Ellegood J, Yee Y, Kerr TM, Muller CL, Blakely RD, Henkelman RM, Veenstra-VanderWeele J, Lerch JP. Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging. Molecular Autism. 9: 24. PMID 29651330 DOI: 10.1186/S13229-018-0210-Z  0.667
2018 Gibson CL, Balbona JT, Niedzwiecki A, Rodriguez P, Nguyen KCQ, Hall DH, Blakely RD. Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration. Plos Genetics. 14: e1007269. PMID 29590100 DOI: 10.1371/journal.pgen.1007269  0.373
2017 Dai H, Jackson CR, Davis GL, Blakely RD, McMahon DG. Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. Journal of Neurodevelopmental Disorders. 9: 38. PMID 29281965 DOI: 10.1186/S11689-017-9215-8  0.417
2017 Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, Sejersen T, Wright J, Zimmerman HH, Karakaya M, Stüve B, ... ... Blakely RD, et al. Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization. Brain : a Journal of Neurology. 140: 2838-2850. PMID 29088354 DOI: 10.1093/brain/awx249  0.453
2017 Davis GL, Stewart A, Stanwood GD, Gowrishankar R, Hahn MK, Blakely RD. Functional Coding Variation in the Presynaptic Dopamine Transporter Associated with Neuropsychiatric Disorders Drives Enhanced Motivation and Context-Dependent Impulsivity in Mice. Behavioural Brain Research. PMID 28964912 DOI: 10.1016/j.bbr.2017.09.043  0.724
2017 Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Lerch JP. Spatial gene expression analysis of neuroanatomical differences in mouse models. Neuroimage. PMID 28882630 DOI: 10.1016/J.Neuroimage.2017.08.065  0.551
2017 Bermingham DP, Hardaway JA, Refai O, Marks CR, Snider SL, Sturgeon SM, Spencer WC, Colbran RJ, Miller DM, Blakely RD. The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters Through a Rho-Dependent Mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28842414 DOI: 10.1523/Jneurosci.1582-17.2017  0.438
2017 Retzlaff CL, Kussrow A, Schorkopf TD, Saetear P, Bornhop DJ, Hardaway JA, Sturgeon SM, Wright J, Blakely RD. Metallo-β-lactamase Domain-containing Protein 1 (MBLAC1) is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone. Acs Chemical Neuroscience. PMID 28783953 DOI: 10.1021/Acschemneuro.7B00232  0.783
2017 Rajkowska G, Mahajan G, Legutko B, Challagundla L, Griswold M, Albert PR, Daigle M, Miguel-Hidalgo JJ, Austin MC, Blakely RD, Steffens DC, Stockmeier CA. Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression. Neuroscience. PMID 28711621 DOI: 10.1016/J.Neuroscience.2017.07.006  0.307
2017 Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Keith Henry L, Stewart A, Veenstra-VanderWeele J, Blakely RD. Serotonin Transporter Blockade Contributes to the Behavioral, Neuronal, and Molecular Effects of Cocaine. British Journal of Pharmacology. PMID 28585320 DOI: 10.1111/Bph.13899  0.646
2017 Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD, Sarter M. Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity. Neurochemistry International. PMID 28577989 DOI: 10.1016/j.neuint.2017.05.022  0.399
2017 Brindley RL, Bauer MB, Blakely RD, Currie KP. Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response. Acs Chemical Neuroscience. PMID 28406285 DOI: 10.1021/acschemneuro.7b00026  0.427
2017 Robson MJ, Quinlan MA, Blakely RD. Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery. Acs Chemical Neuroscience. PMID 28345868 DOI: 10.1021/Acschemneuro.6B00412  0.645
2017 Siemann JK, Muller CL, Forsberg CG, Blakely RD, Veenstra-VanderWeele J, Wallace MT. An autism-associated serotonin transporter variant disrupts multisensory processing. Translational Psychiatry. 7: e1067. PMID 28323282 DOI: 10.1038/Tp.2017.17  0.614
2017 Nackenoff AG, Simmler LD, Baganz NL, Pehrson AL, Sánchez C, Blakely RD. Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine as Revealed Using the SERT Met172 Mouse. Acs Chemical Neuroscience. PMID 28272863 DOI: 10.1021/Acschemneuro.7B00038  0.42
2017 Koshy Cherian A, Kucinski A, Pitchers K, Yegla B, Parikh V, Kim Y, Valuskova P, Gurnani S, Lindsley CW, Blakely RD, Sarter M. Unresponsive choline transporter as a trait neuromarker and a causal mediator of bottom-up attentional biases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28193693 DOI: 10.1523/Jneurosci.3499-16.2017  0.384
2017 Wang H, Salter S, Refai O, Hardy H, Sejersen T, Wright J, Zimmerman H, Weis J, Schara U, Russell M, Abdul-Rahman O, Chilton J, Blakely R, Baple E, Crosby A, et al. Recessively-acting choline transporter mutations associated with severe congenital myasthenia disrupt transporter surface trafficking in vitro and in vivo Neuromuscular Disorders. 27: 414. DOI: 10.1016/J.Nmd.2017.06.454  0.412
2017 Robson M, Quinlan M, Veenstra-VanderWeele J, Watterson D, Blakely R. Do neuroinflammatory pathways contribute to serotoninergic alterations in autism? p38alpha MAPK signaling drives perturbed serotonin clearance, receptor hypersensitivity, and social behavior deficits in the SERT Ala56 mouse Brain, Behavior, and Immunity. 66: e36. DOI: 10.1016/J.Bbi.2017.07.131  0.766
2016 Robinson SB, Andrew Hardaway J, Hardie SL, Wright J, Glynn RM, Bermingham DP, Han Q, Sturgeon SM, Freeman P, Blakely RD. Sequence determinants of the Caenhorhabditis elegansdopamine transporter dictating in vivoaxonal export and synaptic localization. Molecular and Cellular Neurosciences. PMID 27913309 DOI: 10.1016/j.mcn.2016.11.011  0.465
2016 Bermingham DP, Blakely RD. Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. Pharmacological Reviews. 68: 888-953. PMID 27591044 DOI: 10.1124/pr.115.012260  0.463
2016 Bertron JL, Ennis EA, Tarr CJ, Wright J, Dickerson JW, Locuson CW, Blobaum AL, Rook JM, Blakely RD, Lindsley CW. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bioorganic & Medicinal Chemistry Letters. PMID 27575469 DOI: 10.1016/J.Bmcl.2016.08.062  0.301
2016 Muller CL, Anacker AM, Rogers TD, Goeden N, Keller EH, Forsberg CG, Kerr TM, Wender C, Anderson GM, Stanwood GD, Blakely RD, Bonnin A, Veenstra-VanderWeele J. Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27550733 DOI: 10.1038/Npp.2016.166  0.623
2016 Brindley RL, Bauer MB, Blakely RD, Currie KP. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. PMID 27544824 DOI: 10.1016/j.neuropharm.2016.08.015  0.414
2016 Sarter M, Lustig C, Blakely RD, Cherian AK. Cholinergic genetics of visual attention: human and mouse choline transporter capacity variants influence distractibility. Journal of Physiology, Paris. PMID 27404793 DOI: 10.1016/j.jphysparis.2016.07.001  0.373
2016 Ennis EA, Blakely RD. Choline on the Move: Perspectives on the Molecular Physiology and Pharmacology of the Presynaptic Choline Transporter. Advances in Pharmacology (San Diego, Calif.). 76: 175-213. PMID 27288078 DOI: 10.1016/bs.apha.2016.03.001  0.414
2016 Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J, Blakely RD, Gershon MD. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. The Journal of Clinical Investigation. PMID 27111230 DOI: 10.1172/Jci84877  0.656
2016 Iwamoto H, Calcutt MW, Blakely RD. Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine. Neurochemistry International. PMID 27013347 DOI: 10.1016/j.neuint.2016.03.012  0.343
2016 Robson MJ, Zhu CB, Quinlan MA, Botschner DA, Baganz NL, Lindler KM, Thome JG, Hewlett WA, Blakely RD. Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1. Plos One. 11: e0150068. PMID 26930558 DOI: 10.1371/Journal.Pone.0150068  0.603
2016 Bermingham DP, Hardaway JA, Snarrenberg CL, Robinson SB, Folkes OM, Salimando GJ, Jinnah H, Blakely RD. Acute Blockade of the C. elegans Dopamine Transporter DAT-1 by the Mammalian Norepinephrine Transporter Inhibitor Nisoxetine Reveals the Influence of Genetic Modifications of Dopamine Signaling In Vivo. Neurochemistry International. PMID 26850478 DOI: 10.1016/j.neuint.2016.01.008  0.795
2016 Nackenoff A, Simmler L, Baganz N, Pehrson A, Sanchez C, Blakely R. A study of chronic vortioxetine in the SERT Met172 mouse suggests antidepressant-like properties that do not require serotonin transporter inhibition European Neuropsychopharmacology. 26: S252. DOI: 10.1016/S0924-977X(16)31124-5  0.339
2016 Li Z, Margolis KG, Israelyan N, Sturgeon S, Blakely RD, Gershon MD. Sa1676 Cholinergic Neuronal Regulation of Enteric Neurogenesis, GI Motility, and Mucosal Homeostasis: inSIGHT From Mice That Under- or Overexpress the Presynaptic Choline Transporter Gastroenterology. 150: S343. DOI: 10.1016/S0016-5085(16)31205-7  0.395
2016 Margolis KG, Israelyan N, Li Z, Saurman V, Synder I, Kadakia N, Veenstra-Vanderweele J, Blakely RD, Gershon MD. 180 Analysis of a Hyperfunctional Autism-Associated Variant, Knockout, and Inhibition of the Serotonin Reuptake Transporter (SERT) in Mice Reveals That Enteric Nervous System Development, Gastrointestinal Motility, and Mucosal Homeostasis Are Highly Dependent on 5-HT, SERT, and 5-HT4 Receptors Gastroenterology. 150: S47. DOI: 10.1016/S0016-5085(16)30281-5  0.653
2015 Ye R, Quinlan MA, Iwamoto H, Wu HH, Green NH, Jetter CS, McMahon DG, Veestra-VanderWeele J, Levitt P, Blakely RD. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in Synaptic Neuroscience. 7: 20. PMID 26793096 DOI: 10.3389/fnsyn.2015.00020  0.453
2015 Baganz NL, Lindler KM, Zhu CB, Smith JT, Robson MJ, Iwamoto H, Deneris ES, Hewlett WA, Blakely RD. A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors. Translational Psychiatry. 5: e671. PMID 26529424 DOI: 10.1038/Tp.2015.168  0.676
2015 Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD. Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26514584 DOI: 10.1038/Npp.2015.335  0.818
2015 Hardaway JA, Sturgeon SM, Snarrenberg CL, Li Z, Xu XZ, Bermingham DP, Odiase P, Spencer WC, Miller DM, Carvelli L, Hardie SL, Blakely RD. Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9409-23. PMID 26109664 DOI: 10.1523/JNEUROSCI.0800-15.2015  0.788
2015 Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D. Genetic Variation in Alpha2-Adrenoreceptors and Heart Rate Recovery after Exercise. Physiological Genomics. physiolgenomics.0012. PMID 26058836 DOI: 10.1152/Physiolgenomics.00124.2014  0.671
2015 Kovtun O, Sakrikar D, Tomlinson ID, Chang JC, Arzeta-Ferrer X, Blakely RD, Rosenthal SJ. Single-quantum-dot tracking reveals altered membrane dynamics of an attention-deficit/hyperactivity-disorder-derived dopamine transporter coding variant. Acs Chemical Neuroscience. 6: 526-34. PMID 25747272 DOI: 10.1021/Cn500202C  0.433
2015 Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, ... ... Blakely RD, et al. 3D visualization of the regional differences. Molecular Psychiatry. 20: 1. PMID 25648202 DOI: 10.1038/Mp.2014.168  0.524
2015 Chen X, Ye R, Gargus JJ, Blakely RD, Dobrenis K, Sze JY. Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell Reports. PMID 25600870 DOI: 10.1016/j.celrep.2014.12.033  0.395
2015 Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. Acs Chemical Neuroscience. 6: 417-27. PMID 25560927 DOI: 10.1021/Cn5001809  0.46
2015 Berry AS, Blakely RD, Sarter M, Lustig C. Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics. Neuroimage. 108: 386-95. PMID 25536497 DOI: 10.1016/j.neuroimage.2014.12.036  0.364
2015 Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, ... ... Blakely RD, et al. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Molecular Psychiatry. 20: 118-25. PMID 25199916 DOI: 10.1038/Mp.2014.98  0.544
2015 Nackenoff A, Simmler L, Baganz N, Paffenroth K, Stanwood G, Pehrson A, Sanchez C, Blakely R. P.1.g.052 Serotonin transporter-independent actions of the antidepressant vortioxetine as revealed in studies of the SERT Met172 mouse European Neuropsychopharmacology. 25: S264-S265. DOI: 10.1016/S0924-977X(15)30305-9  0.306
2015 Brindley RL, Blakely RD, Currie KP. Controlling Stimulus-Secretion Coupling in Adrenal Chromaffin Cells: A Novel Role for the Serotonin Transporter? Biophysical Journal. 108: 100a-101a. DOI: 10.1016/j.bpj.2014.11.576  0.402
2014 Mergy MA, Gowrishankar R, Gresch PJ, Gantz SC, Williams J, Davis GL, Wheeler CA, Stanwood GD, Hahn MK, Blakely RD. The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants. Proceedings of the National Academy of Sciences of the United States of America. 111: E4779-88. PMID 25331903 DOI: 10.1073/Pnas.1417294111  0.739
2014 Bowton E, Saunders C, Reddy IA, Campbell NG, Hamilton PJ, Henry LK, Coon H, Sakrikar D, Veenstra-VanderWeele JM, Blakely RD, Sutcliffe J, Matthies HJ, Erreger K, Galli A. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Translational Psychiatry. 4: e464. PMID 25313507 DOI: 10.1038/Tp.2014.90  0.827
2014 Prosser RA, Stowie A, Amicarelli M, Nackenoff AG, Blakely RD, Glass JD. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. 275: 184-93. PMID 24950119 DOI: 10.1016/j.neuroscience.2014.06.012  0.393
2014 Hardaway JA, Wang J, Fleming PA, Fleming KA, Whitaker SM, Nackenoff A, Snarrenberg CL, Hardie SL, Zhang B, Blakely RD. An open-source analytical platform for analysis of C. elegans swimming-induced paralysis. Journal of Neuroscience Methods. 232: 58-62. PMID 24792527 DOI: 10.1016/J.Jneumeth.2014.04.024  0.758
2014 Blakely RD, Ortega A, Robinson MB. The brain in flux: genetic, physiologic, and therapeutic perspectives on transporters in the CNS. Neurochemistry International. 73: 1-3. PMID 24751395 DOI: 10.1016/J.Neuint.2014.04.008  0.39
2014 Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. Journal of Neurochemistry. 130: 109-14. PMID 24611756 DOI: 10.1111/Jnc.12697  0.413
2014 Ye R, Carneiro AM, Han Q, Airey D, Sanders-Bush E, Zhang B, Lu L, Williams R, Blakely RD. Quantitative trait loci mapping and gene network analysis implicate protocadherin-15 as a determinant of brain serotonin transporter expression. Genes, Brain, and Behavior. 13: 261-75. PMID 24405699 DOI: 10.1111/Gbb.12119  0.43
2014 Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F. The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction. Pflã¼Gers Archiv : European Journal of Physiology. 466: 25-42. PMID 24337881 DOI: 10.1007/S00424-013-1410-1  0.458
2014 Mergy MA, Gowrishankar R, Davis GL, Jessen TN, Wright J, Stanwood GD, Hahn MK, Blakely RD. Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder. Neurochemistry International. 73: 56-70. PMID 24332984 DOI: 10.1016/j.neuint.2013.11.009  0.719
2014 Holmstrand EC, Lund D, Cherian AK, Wright J, Martin RF, Ennis EA, Stanwood GD, Sarter M, Blakely RD. Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance. Neurochemistry International. 73: 217-28. PMID 24274995 DOI: 10.1016/J.Neuint.2013.11.008  0.806
2014 Gowrishankar R, Hahn MK, Blakely RD. Good riddance to dopamine: roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders. Neurochemistry International. 73: 42-8. PMID 24231471 DOI: 10.1016/j.neuint.2013.10.016  0.732
2014 Ye R, Carneiro AM, Airey D, Sanders-Bush E, Williams RW, Lu L, Wang J, Zhang B, Blakely RD. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes, Brain, and Behavior. 13: 247-60. PMID 24102824 DOI: 10.1111/Gbb.12092  0.379
2014 Margolis KG, Stevanovic KD, Li Z, Blakely R, Veenstra-VanderWeele J, Saurman VE, Gershon MD. 27 Effects of Gain-of-Function Mutation in the Serotonin Transporter (SERT) in Mice Suggest That 5-HT Functions in Intestinal Motility, Mucosal Maintenance, Inflammation, and Prevention of Bacterial Overgrowth and Translocation Gastroenterology. 146: S-8. DOI: 10.1016/S0016-5085(14)60027-5  0.646
2013 Kerr TM, Muller CL, Miah M, Jetter CS, Pfeiffer R, Shah C, Baganz N, Anderson GM, Crawley JN, Sutcliffe JS, Blakely RD, Veenstra-Vanderweele J. Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice. Molecular Autism. 4: 35. PMID 24083388 DOI: 10.1186/2040-2392-4-35  0.639
2013 Paolone G, Mallory CS, Koshy Cherian A, Miller TR, Blakely RD, Sarter M. Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: a model of cholinergic capacity limits. Neuropharmacology. 75: 274-85. PMID 23958450 DOI: 10.1016/j.neuropharm.2013.07.032  0.361
2013 Campbell NG, Zhu CB, Lindler KM, Yaspan BL, Kistner-Griffin E, Hewlett WA, Tate CG, Blakely RD, Sutcliffe JS. Rare coding variants of the adenosine A3 receptor are increased in autism: on the trail of the serotonin transporter regulome. Molecular Autism. 4: 28. PMID 23953133 DOI: 10.1186/2040-2392-4-28  0.415
2013 Dong Y, Dani JA, Blakely RD. Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. Biochemical Pharmacology. 86: 1084-8. PMID 23939187 DOI: 10.1016/j.bcp.2013.07.019  0.406
2013 Parikh V, St Peters M, Blakely RD, Sarter M. The presynaptic choline transporter imposes limits on sustained cortical acetylcholine release and attention. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2326-37. PMID 23392663 DOI: 10.1523/JNEUROSCI.4993-12.2013  0.373
2013 Baganz NL, Blakely RD. A dialogue between the immune system and brain, spoken in the language of serotonin. Acs Chemical Neuroscience. 4: 48-63. PMID 23336044 DOI: 10.1021/cn300186b  0.383
2013 Moritz AE, Foster JD, Gorentla BK, Mazei-Robison MS, Yang JW, Sitte HH, Blakely RD, Vaughan RA. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. The Journal of Biological Chemistry. 288: 20-32. PMID 23161550 DOI: 10.1074/Jbc.M112.407874  0.691
2013 Zurkovsky L, Bychkov E, Tsakem EL, Siedlecki C, Blakely RD, Gurevich EV. Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice. Disease Models & Mechanisms. 6: 171-83. PMID 22864020 DOI: 10.1242/dmm.010363  0.331
2012 Barwick KE, Wright J, Al-Turki S, McEntagart MM, Nair A, Chioza B, Al-Memar A, Modarres H, Reilly MM, Dick KJ, Ruggiero AM, Blakely RD, Hurles ME, Crosby AH. Defective presynaptic choline transport underlies hereditary motor neuropathy. American Journal of Human Genetics. 91: 1103-7. PMID 23141292 DOI: 10.1016/J.Ajhg.2012.09.019  0.393
2012 Ruggiero AM, Wright J, Ferguson SM, Lewis M, Emerson KS, Iwamoto H, Ivy MT, Holmstrand EC, Ennis EA, Weaver CD, Blakely RD. Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake. Acs Chemical Neuroscience. 3: 767-81. PMID 23077721 DOI: 10.1021/Cn3000718  0.826
2012 Hardaway JA, Hardie SL, Whitaker SM, Baas SR, Zhang B, Bermingham DP, Lichtenstein AJ, Blakely RD. Forward genetic analysis to identify determinants of dopamine signaling in Caenorhabditis elegans using swimming-induced paralysis. G3 (Bethesda, Md.). 2: 961-75. PMID 22908044 DOI: 10.1534/G3.112.003533  0.795
2012 Chang JC, Kovtun O, Blakely RD, Rosenthal SJ. Labeling of neuronal receptors and transporters with quantum dots. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. 4: 605-19. PMID 22887823 DOI: 10.1002/Wnan.1186  0.347
2012 Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AM, Piston DW, Blakely RD, Rosenthal SJ. Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8919-29. PMID 22745492 DOI: 10.1523/Jneurosci.0048-12.2012  0.46
2012 Sakrikar D, Mazei-Robison MS, Mergy MA, Richtand NW, Han Q, Hamilton PJ, Bowton E, Galli A, Veenstra-Vanderweele J, Gill M, Blakely RD. Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5385-97. PMID 22514303 DOI: 10.1523/Jneurosci.6033-11.2012  0.816
2012 Veenstra-VanderWeele J, Muller CL, Iwamoto H, Sauer JE, Owens WA, Shah CR, Cohen J, Mannangatti P, Jessen T, Thompson BJ, Ye R, Kerr TM, Carneiro AM, Crawley JN, Sanders-Bush E, ... ... Blakely RD, et al. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proceedings of the National Academy of Sciences of the United States of America. 109: 5469-74. PMID 22431635 DOI: 10.1073/Pnas.1112345109  0.645
2012 Bonnin A, Zhang L, Blakely RD, Levitt P. The SSRI citalopram affects fetal thalamic axon responsiveness to netrin-1 in vitro independently of SERT antagonism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1879-84. PMID 22414815 DOI: 10.1038/Npp.2012.35  0.394
2012 Blakely RD, Edwards RH. Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harbor Perspectives in Biology. 4. PMID 22199021 DOI: 10.1101/cshperspect.a005595  0.385
2012 Veenstra-VanderWeele J, Blakely RD. Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 196-212. PMID 21937981 DOI: 10.1038/Npp.2011.185  0.588
2011 Kovtun O, Tomlinson ID, Sakrikar DS, Chang JC, Blakely RD, Rosenthal SJ. Visualization of the cocaine-sensitive dopamine transporter with ligand-conjugated quantum dots. Acs Chemical Neuroscience. 2: 370-8. PMID 22816024 DOI: 10.1021/Cn200032R  0.391
2011 Combs S, Kaufmann K, Field JR, Blakely RD, Meiler J. Y95 and E444 interaction required for high-affinity S-citalopram binding in the human serotonin transporter. Acs Chemical Neuroscience. 2: 75-81. PMID 22778858 DOI: 10.1021/Cn100066P  0.699
2011 Chang JC, Tomlinson ID, Warnement MR, Iwamoto H, DeFelice LJ, Blakely RD, Rosenthal SJ. A fluorescence displacement assay for antidepressant drug discovery based on ligand-conjugated quantum dots. Journal of the American Chemical Society. 133: 17528-31. PMID 21970724 DOI: 10.1021/Ja204301G  0.358
2011 Ye R, Blakely RD. Natural and engineered coding variation in antidepressant-sensitive serotonin transporters. Neuroscience. 197: 28-36. PMID 21893166 DOI: 10.1016/j.neuroscience.2011.08.056  0.438
2011 Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E, Rudnick G, Noskov SY, DeFelice LJ, ... ... Blakely RD, et al. A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport. The Journal of Biological Chemistry. 286: 30823-36. PMID 21730057 DOI: 10.1074/Jbc.M111.250308  0.831
2011 Zhu CB, Lindler KM, Campbell NG, Sutcliffe JS, Hewlett WA, Blakely RD. Colocalization and regulated physical association of presynaptic serotonin transporters with A₃ adenosine receptors. Molecular Pharmacology. 80: 458-65. PMID 21705486 DOI: 10.1124/Mol.111.071399  0.417
2011 Blakely RD, Veenstra-VanderWeele J. Genetic indeterminism, the 5-HTTLPR, and the paths forward in neuropsychiatric genetics. Archives of General Psychiatry. 68: 457-8. PMID 21536974 DOI: 10.1001/Archgenpsychiatry.2011.34  0.618
2011 Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature. 472: 347-50. PMID 21512572 DOI: 10.1038/Nature09972  0.36
2011 Kohli U, Hahn MK, English BA, Sofowora GG, Muszkat M, Li C, Blakely RD, Stein CM, Kurnik D. Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans. Pharmacogenetics and Genomics. 21: 171-8. PMID 21412203 DOI: 10.1097/Fpc.0B013E328344F63E  0.674
2011 Rasul A, El-Nour H, Blakely RD, Lonne-Rahm SB, Forsberg J, Johansson B, Theodorsson E, Nordlind K. Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain. Archives of Dermatological Research. 303: 625-33. PMID 21400247 DOI: 10.1007/s00403-011-1138-8  0.316
2011 Tomlinson ID, Iwamoto H, Blakely RD, Rosenthal SJ. Biotin tethered homotryptamine derivatives: high affinity probes of the human serotonin transporter (hSERT). Bioorganic & Medicinal Chemistry Letters. 21: 1678-82. PMID 21334895 DOI: 10.1016/J.Bmcl.2011.01.102  0.364
2011 Thompson BJ, Jessen T, Henry LK, Field JR, Gamble KL, Gresch PJ, Carneiro AM, Horton RE, Chisnell PJ, Belova Y, McMahon DG, Daws LC, Blakely RD. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. 108: 3785-90. PMID 21282638 DOI: 10.1073/Pnas.1011920108  0.822
2011 Erickson SL, Gandhi AR, Asafu-Adjei JK, Sampson AR, Miner L, Blakely RD, Sesack SR. Chronic desipramine treatment alters tyrosine hydroxylase but not norepinephrine transporter immunoreactivity in norepinephrine axons in the rat prefrontal cortex. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 1219-32. PMID 21208501 DOI: 10.1017/S1461145710001525  0.653
2011 Thompson BJ, Jessen T, Henry LK, Field JR, Gamble KL, Gresch PJ, Carneiro AM, Horton RE, Chisnell PJ, Belova Y, McMahon DG, Daws LC, Blakely RD. Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 9, (3785-3790) DOI: 10.1073/pnas.1011920108) Proceedings of the National Academy of Sciences of the United States of America. 108: 6689. DOI: 10.1073/Pnas.1104147108  0.809
2010 Li Z, Caron MG, Blakely RD, Margolis KG, Gershon MD. Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16730-40. PMID 21148012 DOI: 10.1523/Jneurosci.2276-10.2010  0.332
2010 Lund D, Ruggiero AM, Ferguson SM, Wright J, English BA, Reisz PA, Whitaker SM, Peltier AC, Blakely RD. Motor neuron-specific overexpression of the presynaptic choline transporter: impact on motor endurance and evoked muscle activity. Neuroscience. 171: 1041-53. PMID 20888396 DOI: 10.1016/J.Neuroscience.2010.09.057  0.795
2010 Zhu CB, Lindler KM, Owens AW, Daws LC, Blakely RD, Hewlett WA. Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 2510-20. PMID 20827273 DOI: 10.1038/Npp.2010.116  0.411
2010 English BA, Appalsamy M, Diedrich A, Ruggiero AM, Lund D, Wright J, Keller NR, Louderback KM, Robertson D, Blakely RD. Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter. American Journal of Physiology. Heart and Circulatory Physiology. 299: H799-810. PMID 20601463 DOI: 10.1152/Ajpheart.00170.2010  0.794
2010 Matthies HJ, Moore JL, Saunders C, Matthies DS, Lapierre LA, Goldenring JR, Blakely RD, Galli A. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7863-77. PMID 20534835 DOI: 10.1523/Jneurosci.4574-09.2010  0.584
2010 Bowton E, Saunders C, Erreger K, Sakrikar D, Matthies HJ, Sen N, Jessen T, Colbran RJ, Caron MG, Javitch JA, Blakely RD, Galli A. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6048-57. PMID 20427663 DOI: 10.1523/Jneurosci.5094-09.2010  0.561
2010 Holmstrand EC, Asafu-Adjei J, Sampson AR, Blakely RD, Sesack SR. Ultrastructural localization of high-affinity choline transporter in the rat anteroventral thalamus and ventral tegmental area: differences in axon morphology and transporter distribution. The Journal of Comparative Neurology. 518: 1908-24. PMID 20394050 DOI: 10.1002/Cne.22310  0.79
2010 Field JR, Henry LK, Blakely RD. Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine. The Journal of Biological Chemistry. 285: 11270-80. PMID 20159976 DOI: 10.1074/Jbc.M109.093658  0.825
2009 English BA, Hahn MK, Gizer IR, Mazei-Robison M, Steele A, Kurnik DM, Stein MA, Waldman ID, Blakely RD. Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. Journal of Neurodevelopmental Disorders. 1: 252-63. PMID 21547719 DOI: 10.1007/S11689-009-9033-8  0.792
2009 Veenstra-Vanderweele J, Jessen TN, Thompson BJ, Carter M, Prasad HC, Steiner JA, Sutcliffe JS, Blakely RD. Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. Journal of Neurodevelopmental Disorders. 1: 158-71. PMID 19960097 DOI: 10.1007/S11689-009-9020-0  0.716
2009 Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD. cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Molecular Brain. 2: 26. PMID 19656393 DOI: 10.1186/1756-6606-2-26  0.614
2009 Matthies HJ, Han Q, Shields A, Wright J, Moore JL, Winder DG, Galli A, Blakely RD. Subcellular localization of the antidepressant-sensitive norepinephrine transporter. Bmc Neuroscience. 10: 65. PMID 19545450 DOI: 10.1186/1471-2202-10-65  0.692
2009 Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD. Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 106: 2047-52. PMID 19179283 DOI: 10.1073/Pnas.0809449106  0.449
2009 Prasad HC, Steiner JA, Sutcliffe JS, Blakely RD. Enhanced activity of human serotonin transporter variants associated with autism. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 163-73. PMID 18957375 DOI: 10.1098/Rstb.2008.0143  0.633
2009 Kaufmann KW, Dawson ES, Henry LK, Field JR, Blakely RD, Meiler J. Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies. Proteins. 74: 630-42. PMID 18704946 DOI: 10.1002/Prot.22178  0.82
2008 Tomlinson ID, Chang J, Iwamoto H, De Felice LJ, Blakely RD, Rosenthal SJ. Targeting the human serotonin transporter (hSERT) with quantum dots. Proceedings of Spie--the International Society For Optical Engineering. 6866: nihpa155701. PMID 19936040 DOI: 10.1117/12.782801  0.427
2008 Zhao J, Matthies DS, Botzolakis EJ, Macdonald RL, Blakely RD, Hedera P. Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13938-51. PMID 19091982 DOI: 10.1523/JNEUROSCI.4668-08.2008  0.325
2008 Carvelli L, Blakely RD, DeFelice LJ. Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 105: 14192-7. PMID 18768815 DOI: 10.1073/pnas.0802214105  0.445
2008 Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N. Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Neuroscience. 156: 129-42. PMID 18674600 DOI: 10.1016/j.neuroscience.2008.06.063  0.373
2008 Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD. Anomalous dopamine release associated with a human dopamine transporter coding variant. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7040-6. PMID 18614672 DOI: 10.1523/Jneurosci.0473-08.2008  0.771
2008 Kim CH, Waldman ID, Blakely RD, Kim KS. Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder. Annals of the New York Academy of Sciences. 1129: 256-60. PMID 18591486 DOI: 10.1196/Annals.1417.023  0.37
2008 Misawa H, Fujigaya H, Nishimura T, Moriwaki Y, Okuda T, Kawashima K, Nakata K, Ruggiero AM, Blakely RD, Nakatsu F, Ohno H. Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice. The European Journal of Neuroscience. 27: 3109-17. PMID 18554297 DOI: 10.1111/J.1460-9568.2008.06268.X  0.427
2008 Steiner JA, Carneiro AM, Blakely RD. Going with the flow: trafficking-dependent and -independent regulation of serotonin transport. Traffic (Copenhagen, Denmark). 9: 1393-402. PMID 18445122 DOI: 10.1111/j.1600-0854.2008.00757.x  0.617
2008 Carneiro AM, Cook EH, Murphy DL, Blakely RD. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. The Journal of Clinical Investigation. 118: 1544-52. PMID 18317590 DOI: 10.1172/Jci33374  0.44
2008 Henry LK, Blakely RD. Distinctions between dopamine transporter antagonists could be just around the bend. Molecular Pharmacology. 73: 616-8. PMID 18156312 DOI: 10.1124/mol.107.044586  0.724
2008 Hahn MK, Blackford JU, Haman K, Mazei-Robison M, English BA, Prasad HC, Steele A, Hazelwood L, Fentress HM, Myers R, Blakely RD, Sanders-Bush E, Shelton R. Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Genes, Brain, and Behavior. 7: 487-95. PMID 18081710 DOI: 10.1111/J.1601-183X.2007.00384.X  0.784
2007 Henry LK, Meiler J, Blakely RD. Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular Interventions. 7: 306-9. PMID 18199851 DOI: 10.1124/mi.7.6.4  0.761
2007 McDonald PW, Hardie SL, Jessen TN, Carvelli L, Matthies DS, Blakely RD. Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14216-27. PMID 18094261 DOI: 10.1523/JNEUROSCI.2992-07.2007  0.597
2007 Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, France CP, Gore JC, Daws LC, Avison MJ, Galli A. Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. Plos Biology. 5: e274. PMID 17941718 DOI: 10.1371/Journal.Pbio.0050274  0.553
2007 Mason JN, Deecher DC, Richmond RL, Stack G, Mahaney PE, Trybulski E, Winneker RC, Blakely RD. Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. The Journal of Pharmacology and Experimental Therapeutics. 323: 720-9. PMID 17673606 DOI: 10.1124/jpet.107.125716  0.383
2007 Ismair MG, Kullak-Ublick GA, Blakely RD, Fried M, Vavricka SR. Tegaserod inhibits the serotonin transporter SERT. Digestion. 75: 90-5. PMID 17510552 DOI: 10.1159/000102962  0.481
2007 Zhu CB, Steiner JA, Munn JL, Daws LC, Hewlett WA, Blakely RD. Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. The Journal of Pharmacology and Experimental Therapeutics. 322: 332-40. PMID 17460150 DOI: 10.1124/Jpet.107.121665  0.602
2007 Blakely RD, DeFelice LJ. All aglow about presynaptic receptor regulation of neurotransmitter transporters. Molecular Pharmacology. 71: 1206-8. PMID 17329498 DOI: 10.1124/mol.107.035493  0.445
2007 Sung U, Blakely RD. Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A. Molecular and Cellular Neurosciences. 34: 251-60. PMID 17188889 DOI: 10.1016/j.mcn.2006.11.007  0.372
2007 Hahn MK, Blakely RD. The functional impact of SLC6 transporter genetic variation. Annual Review of Pharmacology and Toxicology. 47: 401-41. PMID 17067279 DOI: 10.1146/annurev.pharmtox.47.120505.105242  0.74
2007 Dipace C, Sung U, Binda F, Blakely RD, Galli A. Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Molecular Pharmacology. 71: 230-9. PMID 17032905 DOI: 10.1124/Mol.106.026690  0.602
2007 Bazalakova MH, Wright J, Schneble EJ, McDonald MP, Heilman CJ, Levey AI, Blakely RD. Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice. Genes, Brain, and Behavior. 6: 411-24. PMID 17010154 DOI: 10.1111/J.1601-183X.2006.00269.X  0.801
2006 Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS. A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Proceedings of the National Academy of Sciences of the United States of America. 103: 19164-9. PMID 17146058 DOI: 10.1073/Pnas.0510836103  0.707
2006 Iwamoto H, Blakely RD, De Felice LJ. Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9851-9. PMID 17005849 DOI: 10.1523/JNEUROSCI.1862-06.2006  0.436
2006 Carneiro AM, Blakely RD. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. The Journal of Biological Chemistry. 281: 24769-80. PMID 16803896 DOI: 10.1074/jbc.M603877200  0.474
2006 Tomlinson ID, Mason JN, Blakely RD, Rosenthal SJ. High affinity inhibitors of the dopamine transporter (DAT): novel biotinylated ligands for conjugation to quantum dots. Bioorganic & Medicinal Chemistry Letters. 16: 4664-7. PMID 16784853 DOI: 10.1016/J.Bmcl.2006.05.097  0.397
2006 Matthies DS, Fleming PA, Wilkes DM, Blakely RD. The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6200-12. PMID 16763028 DOI: 10.1523/Jneurosci.5036-05.2006  0.426
2006 McDonald PW, Jessen T, Field JR, Blakely RD. Dopamine signaling architecture in Caenorhabditis elegans. Cellular and Molecular Neurobiology. 26: 593-618. PMID 16724276 DOI: 10.1007/S10571-006-9003-6  0.723
2006 Bazalakova MH, Blakely RD. The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. Handbook of Experimental Pharmacology. 525-44. PMID 16722248 DOI: 10.1007/3-540-29784-7_21  0.801
2006 Mazei-Robinson MS, Blakely RD. ADHD and the dopamine transporter: are there reasons to pay attention? Handbook of Experimental Pharmacology. 373-415. PMID 16722244 DOI: 10.1007/3-540-29784-7-17  0.386
2006 Henry LK, Defelice LJ, Blakely RD. Getting the message across: a recent transporter structure shows the way. Neuron. 49: 791-6. PMID 16543127 DOI: 10.1016/j.neuron.2006.03.002  0.753
2006 Keller NR, Diedrich A, Appalsamy M, Miller LC, Caron MG, McDonald MP, Shelton RC, Blakely RD, Robertson D. Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension. Neuroscience. 139: 931-46. PMID 16515844 DOI: 10.1016/J.Neuroscience.2006.01.008  0.434
2006 Zhu CB, Blakely RD, Hewlett WA. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2121-31. PMID 16452991 DOI: 10.1038/sj.npp.1301029  0.323
2006 Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR. Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1571-8. PMID 16452680 DOI: 10.1523/JNEUROSCI.4450-05.2006  0.636
2006 Binda F, Lute BJ, Dipace C, Blakely RD, Galli A. The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak current. Neuropharmacology. 50: 354-61. PMID 16289633 DOI: 10.1016/J.Neuropharm.2005.09.012  0.561
2006 Fukumoto T, Blakely R, Levin M. Serotonin transporter function is an early step in left-right patterning in chick and frog embryos. Developmental Neuroscience. 27: 349-63. PMID 16280633 DOI: 10.1159/000088451  0.411
2006 Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, Blakely RD. Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. The Journal of Biological Chemistry. 281: 2012-23. PMID 16272152 DOI: 10.1074/Jbc.M505055200  0.818
2005 Guidry G, Willison BD, Blakely RD, Landis SC, Habecker BA. Developmental expression of the high affinity choline transporter in cholinergic sympathetic neurons. Autonomic Neuroscience : Basic & Clinical. 123: 54-61. PMID 16278103 DOI: 10.1016/J.Autneu.2005.10.001  0.364
2005 Mazei-Robison MS, Blakely RD. Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala. Neuropharmacology. 49: 737-49. PMID 16212992 DOI: 10.1016/j.neuropharm.2005.08.012  0.752
2005 Tomlinson ID, Mason JN, Blakely RD, Rosenthal SJ. Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots. Bioorganic & Medicinal Chemistry Letters. 15: 5307-10. PMID 16183285 DOI: 10.1016/J.Bmcl.2005.08.030  0.385
2005 Mazei-Robison MS, Couch RS, Shelton RC, Stein MA, Blakely RD. Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Neuropharmacology. 49: 724-36. PMID 16171832 DOI: 10.1016/j.neuropharm.2005.08.003  0.691
2005 Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD. Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 11545-50. PMID 16055563 DOI: 10.1073/Pnas.0501432102  0.469
2005 Blakely RD, Defelice LJ, Galli A. Biogenic amine neurotransmitter transporters: just when you thought you knew them. Physiology (Bethesda, Md.). 20: 225-31. PMID 16024510 DOI: 10.1152/Physiol.00013.2005  0.595
2005 Sutcliffe JS, Delahanty RJ, Prasad HC, McCauley JL, Han Q, Jiang L, Li C, Folstein SE, Blakely RD. Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. American Journal of Human Genetics. 77: 265-79. PMID 15995945 DOI: 10.1086/432648  0.387
2005 Nass R, Hahn MK, Jessen T, McDonald PW, Carvelli L, Blakely RD. A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking. Journal of Neurochemistry. 94: 774-85. PMID 15992384 DOI: 10.1111/j.1471-4159.2005.03205.x  0.782
2005 Sung U, Jennings JL, Link AJ, Blakely RD. Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins. Biochemical and Biophysical Research Communications. 333: 671-8. PMID 15963952 DOI: 10.1016/J.Bbrc.2005.05.165  0.383
2005 Hahn MK, Mazei-Robison MS, Blakely RD. Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation. Molecular Pharmacology. 68: 457-66. PMID 15894713 DOI: 10.1124/mol.105.011270  0.835
2005 Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S. Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Molecular Pharmacology. 67: 2077-87. PMID 15774771 DOI: 10.1124/Mol.104.009555  0.426
2005 Mason JN, Farmer H, Tomlinson ID, Schwartz JW, Savchenko V, DeFelice LJ, Rosenthal SJ, Blakely RD. Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation. Journal of Neuroscience Methods. 143: 3-25. PMID 15763132 DOI: 10.1016/J.Jneumeth.2004.09.028  0.457
2005 Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A. Amphetamine induces dopamine efflux through a dopamine transporter channel. Proceedings of the National Academy of Sciences of the United States of America. 102: 3495-500. PMID 15728379 DOI: 10.1073/Pnas.0407737102  0.559
2005 Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. The Journal of Biological Chemistry. 280: 15649-58. PMID 15728187 DOI: 10.1074/jbc.M410858200  0.45
2005 Egli RE, Kash TL, Choo K, Savchenko V, Matthews RT, Blakely RD, Winder DG. Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 657-68. PMID 15602500 DOI: 10.1038/Sj.Npp.1300639  0.69
2004 Carvelli L, McDonald PW, Blakely RD, Defelice LJ. Dopamine transporters depolarize neurons by a channel mechanism. Proceedings of the National Academy of Sciences of the United States of America. 101: 16046-51. PMID 15520385 DOI: 10.1073/pnas.0403299101  0.566
2004 Zhu CB, Hewlett WA, Francis SH, Corbin JD, Blakely RD. Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil. European Journal of Pharmacology. 504: 1-6. PMID 15507214 DOI: 10.1016/J.Ejphar.2004.09.023  0.455
2004 Ferguson SM, Bazalakova M, Savchenko V, Tapia JC, Wright J, Blakely RD. Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 8762-7. PMID 15173594 DOI: 10.1073/Pnas.0401667101  0.815
2004 Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Molecular Pharmacology. 65: 1462-74. PMID 15155839 DOI: 10.1124/mol.65.6.1462  0.408
2004 McCauley JL, Olson LM, Dowd M, Amin T, Steele A, Blakely RD, Folstein SE, Haines JL, Sutcliffe JS. Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 127: 104-12. PMID 15108191 DOI: 10.1002/Ajmg.B.20151  0.327
2004 Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR. Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Synapse (New York, N.Y.). 52: 233-44. PMID 15103690 DOI: 10.1002/Syn.20023  0.661
2004 Gates J, Ferguson SM, Blakely RD, Apparsundaram S. Regulation of choline transporter surface expression and phosphorylation by protein kinase C and protein phosphatase 1/2A. The Journal of Pharmacology and Experimental Therapeutics. 310: 536-45. PMID 15064333 DOI: 10.1124/Jpet.104.066795  0.6
2004 Hoover DB, Ganote CE, Ferguson SM, Blakely RD, Parsons RL. Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovascular Research. 62: 112-21. PMID 15023558 DOI: 10.1016/J.Cardiores.2004.01.012  0.536
2004 Ferguson SM, Blakely RD. The choline transporter resurfaces: new roles for synaptic vesicles? Molecular Interventions. 4: 22-37. PMID 14993474 DOI: 10.1124/Mi.4.1.22  0.623
2004 Proskocil BJ, Sekhon HS, Jia Y, Savchenko V, Blakely RD, Lindstrom J, Spindel ER. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology. 145: 2498-506. PMID 14764638 DOI: 10.1210/En.2003-1728  0.31
2004 Peng L, Sokoloff L, Takahashi S, Gotoh J, Driscoll BF, Law MJ, Holtzman D, Mulkern R, Tsuji M, Cook C, Meyers R, Kaldis P, Hemmer W, Zanolla E, Wallimann T, ... ... Blakely RD, et al. Contents Vol. 18, 1996 Developmental Neuroscience. 18: 559-561. DOI: 10.1159/000111455  0.714
2004 Lee SL, Lynch B, Wang J, Schnetz-Boutaud N, Pericak-Vance MA, Blakely RD, Haines JL. P4-144 The high-affinity choline transporter (CHT) functional variant 189V in Alzheimer's disease: an association study Neurobiology of Aging. 25: S516. DOI: 10.1016/S0197-4580(04)81702-0  0.345
2004 Bazalakova MH, Ferguson SM, Wright J, McDonald MP, Blakely RD. P2-086 Modeling presynaptic cholinergic hypofunction: pharmacological and behavioral studies in choline transporter heterozygous mice Neurobiology of Aging. 25: S248. DOI: 10.1016/S0197-4580(04)80833-9  0.805
2003 Savchenko V, Sung U, Blakely RD. Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody. Molecular and Cellular Neurosciences. 24: 1131-50. PMID 14697674 DOI: 10.1016/S1044-7431(03)00235-5  0.368
2003 Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI. Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Molecular Pharmacology. 64: 1309-16. PMID 14645660 DOI: 10.1124/Mol.64.6.1309  0.606
2003 Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD. Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9697-709. PMID 14585997 DOI: 10.1523/Jneurosci.23-30-09697.2003  0.61
2003 Miner LH, Schroeter S, Blakely RD, Sesack SR. Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals. The Journal of Comparative Neurology. 466: 478-94. PMID 14566944 DOI: 10.1002/cne.10898  0.611
2003 Henry LK, Adkins EM, Han Q, Blakely RD. Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I. The Journal of Biological Chemistry. 278: 37052-63. PMID 12869570 DOI: 10.1074/Jbc.M305514200  0.829
2003 Kus L, Borys E, Ping Chu Y, Ferguson SM, Blakely RD, Emborg ME, Kordower JH, Levey AI, Mufson EJ. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. The Journal of Comparative Neurology. 463: 341-57. PMID 12820166 DOI: 10.1002/Cne.10759  0.564
2003 Hahn MK, Robertson D, Blakely RD. A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4470-8. PMID 12805287  0.717
2003 Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD. A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1697-709. PMID 12629174 DOI: 10.1523/Jneurosci.23-05-01697.2003  0.535
2003 Ansah TA, Ramamoorthy S, Montañez S, Daws LC, Blakely RD. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of Pharmacology and Experimental Therapeutics. 305: 956-65. PMID 12626658 DOI: 10.1124/Jpet.102.047134  0.466
2003 Schwartz JW, Blakely RD, DeFelice LJ. Binding and transport in norepinephrine transporters. Real-time, spatially resolved analysis in single cells using a fluorescent substrate. The Journal of Biological Chemistry. 278: 9768-77. PMID 12499385 DOI: 10.1074/jbc.M209824200  0.462
2003 Nass R, Blakely RD. The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration. Annual Review of Pharmacology and Toxicology. 43: 521-44. PMID 12415122 DOI: 10.1146/annurev.pharmtox.43.100901.135934  0.396
2003 Hahn MK, Robertson D, Blakely RD. A Mutation in the Human Norepinephrine Transporter Gene (SLC6A2) Associated with Orthostatic Intolerance Disrupts Surface Expression of Mutant and Wild-Type Transporters The Journal of Neuroscience. 23: 4470-4478. DOI: 10.1523/Jneurosci.23-11-04470.2003  0.738
2003 Tomlinson ID, Mason J, Burton JN, Blakely R, Rosenthal SJ. The design and synthesis of novel derivatives of the dopamine uptake inhibitors GBR 12909 and GBR 12935. High-affinity dopaminergic ligands for conjugation with highly fluorescent cadmium selenide/zinc sulfide core/shell nanocrystals Tetrahedron. 59: 8035-8047. DOI: 10.1016/S0040-4020(03)01179-7  0.339
2002 Garland EM, Hahn MK, Ketch TP, Keller NR, Kim CH, Kim KS, Biaggioni I, Shannon JR, Blakely RD, Robertson D. Genetic basis of clinical catecholamine disorders. Annals of the New York Academy of Sciences. 971: 506-14. PMID 12438171 DOI: 10.1111/J.1749-6632.2002.Tb04515.X  0.709
2002 Hahn MK, Blakely RD. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. The Pharmacogenomics Journal. 2: 217-35. PMID 12196911 DOI: 10.1038/sj.tpj.6500106  0.751
2002 Bauman PA, Blakely RD. Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity. Archives of Biochemistry and Biophysics. 404: 80-91. PMID 12127072 DOI: 10.1016/S0003-9861(02)00232-1  0.429
2002 Rosenthal SJ, Tomlinson I, Adkins EM, Schroeter S, Adams S, Swafford L, McBride J, Wang Y, DeFelice LJ, Blakely RD. Targeting cell surface receptors with ligand-conjugated nanocrystals. Journal of the American Chemical Society. 124: 4586-94. PMID 11971705 DOI: 10.1021/Ja003486S  0.811
2002 Serafeim A, Grafton G, Chamba A, Gregory CD, Blakely RD, Bowery NG, Barnes NM, Gordon J. 5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors. Blood. 99: 2545-53. PMID 11895792 DOI: 10.1182/blood.V99.7.2545  0.402
2002 Nass R, Hall DH, Miller DM, Blakely RD. Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 99: 3264-9. PMID 11867711 DOI: 10.1073/pnas.042497999  0.353
2001 Apparsundaram S, Ferguson SM, Blakely RD. Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Biochemical Society Transactions. 29: 711-6. PMID 11709061 DOI: 10.1042/Bst0290711  0.63
2001 Blakely RD. Physiological genomics of antidepressant targets: keeping the periphery in mind. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8319-23. PMID 11606618 DOI: 10.1523/Jneurosci.21-21-08319.2001  0.486
2001 Blakely RD. Neurobiology. Dopamine's reversal of fortune. Science (New York, N.Y.). 293: 2407-9. PMID 11577225 DOI: 10.1126/science.1065931  0.363
2001 Robertson D, Flattem N, Tellioglu T, Carson R, Garland E, Shannon JR, Jordan J, Jacob G, Blakely RD, Biaggioni I. Familial orthostatic tachycardia due to norepinephrine transporter deficiency. Annals of the New York Academy of Sciences. 940: 527-43. PMID 11458707 DOI: 10.1111/J.1749-6632.2001.Tb03703.X  0.813
2001 Belous AR, Ramamoorthy S, Blakely RD, Factor MI, Dupin AM, Katasonov AB, Lozier RH, Beniashvili AG, Morozova MA, Brusov OS. The state of the serotonin transporter protein in the platelets of patients with somatoform [correction of somatiform] disorders. Neuroscience and Behavioral Physiology. 31: 185-9. PMID 11392354 DOI: 10.1023/A:1005268425375  0.332
2001 Ren ZG, Pörzgen P, Zhang JM, Chen XR, Amara SG, Blakely RD, Sieber-Blum M. Autocrine regulation of norepinephrine transporter expression. Molecular and Cellular Neurosciences. 17: 539-50. PMID 11273648 DOI: 10.1006/mcne.2000.0946  0.578
2001 Adkins EM, Barker EL, Blakely RD. Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition. Molecular Pharmacology. 59: 514-23. PMID 11179447 DOI: 10.1124/Mol.59.3.514  0.819
2001 Apparsundaram S, Ferguson S, Blakely R. Molecular cloning and characterization of hemicholinium-3-sensitive choline transporters Biochemical Society Transactions. 29: A95-A95. DOI: 10.1042/Bst029A095A  0.623
2000 Miner LH, Schroeter S, Blakely RD, Sesack SR. Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. The Journal of Comparative Neurology. 427: 220-34. PMID 11054690 DOI: 10.1002/1096-9861(20001113)427:2<220::AID-CNE5>3.0.CO;2-P  0.663
2000 Apparsundaram S, Ferguson SM, George AL, Blakely RD. Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. Biochemical and Biophysical Research Communications. 276: 862-7. PMID 11027560 DOI: 10.1006/Bbrc.2000.3561  0.618
2000 Bauman AL, Apparsundaram S, Ramamoorthy S, Wadzinski BE, Vaughan RA, Blakely RD. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7571-8. PMID 11027216 DOI: 10.1523/Jneurosci.20-20-07571.2000  0.819
2000 Blakely RD, Sung U. SNARE-ing neurotransmitter transporters. Nature Neuroscience. 3: 969-71. PMID 11017164 DOI: 10.1038/79898  0.392
2000 Blakely RD, Bauman AL. Biogenic amine transporters: regulation in flux. Current Opinion in Neurobiology. 10: 328-36. PMID 10851182 DOI: 10.1016/S0959-4388(00)00088-X  0.822
2000 Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. 420: 211-32. PMID 10753308 DOI: 10.1002/(Sici)1096-9861(20000501)420:2<211::Aid-Cne5>3.0.Co;2-3  0.675
2000 Rakhshan F, Day TA, Blakely RD, Barker EL. Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells. The Journal of Pharmacology and Experimental Therapeutics. 292: 960-7. PMID 10688610  0.687
2000 Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. The New England Journal of Medicine. 342: 541-9. PMID 10684912 DOI: 10.1056/NEJM200002243420803  0.8
2000 Flattem NL, Blakely RD. Modified structure of the human serotonin transporter promoter. Molecular Psychiatry. 5: 110-5. PMID 10673778 DOI: 10.1038/Sj.Mp.4000585  0.802
1999 Robertson D, Biaggioni I, Ertl AC, Robertson RM, Diedrich A, Blakely RD, Flattem N, Shannon JR. Orthostatic intolerance: emerging genetic and environmental etiologies. Journal of Gravitational Physiology : a Journal of the International Society For Gravitational Physiology. 6: P51-4. PMID 11543025  0.775
1999 Ramamoorthy S, Blakely RD. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science (New York, N.Y.). 285: 763-6. PMID 10427004 DOI: 10.1126/Science.285.5428.763  0.457
1999 Barker EL, Moore KR, Rakhshan F, Blakely RD. Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4705-17. PMID 10366604 DOI: 10.1523/Jneurosci.19-12-04705.1999  0.735
1999 Tatsumi M, Jansen K, Blakely RD, Richelson E. Pharmacological profile of neuroleptics at human monoamine transporters. European Journal of Pharmacology. 368: 277-83. PMID 10193665 DOI: 10.1016/S0014-2999(99)00005-9  0.372
1999 Leitner B, Lovisetti-Scamihorn P, Heilmann J, Striessnig J, Blakely RD, Eiden LE, Winkler H. Subcellular localization of chromogranins, calcium channels, amine carriers, and proteins of the exocytotic machinery in bovine splenic nerve. Journal of Neurochemistry. 72: 1110-6. PMID 10037482 DOI: 10.1046/J.1471-4159.1999.0721110.X  0.318
1999 Upton AL, Salichon N, Lebrand C, Ravary A, Blakely R, Seif I, Gaspar P. Excess of Serotonin (5-HT) Alters the Segregation of Ispilateral and Contralateral Retinal Projections in Monoamine Oxidase A Knock-Out Mice: Possible Role of 5-HT Uptake in Retinal Ganglion Cells During Development The Journal of Neuroscience. 19: 7007-7024. DOI: 10.1523/Jneurosci.19-16-07007.1999  0.394
1998 Lebrand C, Cases O, Wehrlé R, Blakely RD, Edwards RH, Gaspar P. Transient developmental expression of monoamine transporters in the rodent forebrain. The Journal of Comparative Neurology. 401: 506-24. PMID 9826275 DOI: 10.1002/(Sici)1096-9861(19981130)401:4<506::Aid-Cne5>3.0.Co;2-#  0.395
1998 Apparsundaram S, Galli A, DeFelice LJ, Hartzell HC, Blakely RD. Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells. The Journal of Pharmacology and Experimental Therapeutics. 287: 733-43. PMID 9808704  0.535
1998 Galli A, Blakely RD, DeFelice LJ. Patch-clamp and amperometric recordings from norepinephrine transporters: channel activity and voltage-dependent uptake. Proceedings of the National Academy of Sciences of the United States of America. 95: 13260-5. PMID 9789076 DOI: 10.1073/Pnas.95.22.13260  0.61
1998 Barker EL, Blakely RD. Structural determinants of neurotransmitter transport using cross-species chimeras: studies on serotonin transporter. Methods in Enzymology. 296: 475-98. PMID 9779469 DOI: 10.1016/S0076-6879(98)96035-9  0.755
1998 Ramamoorthy S, Melikian HE, Qian Y, Blakely RD. Biosynthesis, N-glycosylation, and surface trafficking of biogenic amine transporter proteins. Methods in Enzymology. 296: 347-70. PMID 9779460 DOI: 10.1016/S0076-6879(98)96026-8  0.82
1998 Jayanthi LD, Apparsundaram S, Malone MD, Ward E, Miller DM, Eppler M, Blakely RD. The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter. Molecular Pharmacology. 54: 601-9. PMID 9765501  0.403
1998 Blakely RD, Ramamoorthy S, Schroeter S, Qian Y, Apparsundaram S, Galli A, DeFelice LJ. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biological Psychiatry. 44: 169-78. PMID 9693389 DOI: 10.1016/S0006-3223(98)00124-3  0.723
1998 Barker EL, Perlman MA, Adkins EM, Houlihan WJ, Pristupa ZB, Niznik HB, Blakely RD. High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. The Journal of Biological Chemistry. 273: 19459-68. PMID 9677366 DOI: 10.1074/Jbc.273.31.19459  0.824
1998 Fritz JD, Jayanthi LD, Thoreson MA, Blakely RD. Cloning and chromosomal mapping of the murine norepinephrine transporter. Journal of Neurochemistry. 70: 2241-51. PMID 9603188 DOI: 10.1046/J.1471-4159.1998.70062241.X  0.399
1998 Zhu MY, Blakely RD, Apparsundaram S, Ordway GA. Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. Journal of Neurochemistry. 70: 1547-55. PMID 9523572 DOI: 10.1046/J.1471-4159.1998.70041547.X  0.301
1998 Ramamoorthy S, Giovanetti E, Qian Y, Blakely RD. Phosphorylation and regulation of antidepressant-sensitive serotonin transporters. The Journal of Biological Chemistry. 273: 2458-66. PMID 9442097 DOI: 10.1074/Jbc.273.4.2458  0.611
1998 Blakely RD, Apparsundaram S. Structural diversity in the catecholamine transporter gene family: molecular cloning and characterization of an L-epinephrine transporter from bullfrog sympathetic ganglia. Advances in Pharmacology (San Diego, Calif.). 42: 206-10. PMID 9327880 DOI: 10.1016/S1054-3589(08)60729-2  0.455
1998 Justice JB, Danek KS, Kable JW, Barker EL, Blakely RD. Voltammetric approaches to kinetics and mechanism of the norepinephrine transporter. Advances in Pharmacology (San Diego, Calif.). 42: 191-4. PMID 9327876 DOI: 10.1016/S1054-3589(08)60725-5  0.733
1997 Tatsumi M, Groshan K, Blakely RD, Richelson E. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology. 340: 249-58. PMID 9537821 DOI: 10.1016/S0014-2999(97)01393-9  0.389
1997 Eshleman AJ, Stewart E, Evenson AK, Mason JN, Blakely RD, Janowsky A, Neve KA. Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters. Journal of Neurochemistry. 69: 1459-66. PMID 9326274 DOI: 10.1046/J.1471-4159.1997.69041459.X  0.459
1997 Bradley CC, Blakely RD. Alternative splicing of the human serotonin transporter gene. Journal of Neurochemistry. 69: 1356-67. PMID 9326263 DOI: 10.1046/J.1471-4159.1997.69041356.X  0.579
1997 Schroeter S, Levey AI, Blakely RD. Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Molecular and Cellular Neurosciences. 9: 170-84. PMID 9245500 DOI: 10.1006/mcne.1997.0619  0.45
1997 Steininger TL, Wainer BH, Blakely RD, Rye DB. Serotonergic dorsal raphe nucleus projections to the cholinergic and noncholinergic neurons of the pedunculopontine tegmental region: a light and electron microscopic anterograde tracing and immunohistochemical study. The Journal of Comparative Neurology. 382: 302-22. PMID 9183696 DOI: 10.1002/(Sici)1096-9861(19970609)382:3<302::Aid-Cne2>3.0.Co;2-7  0.325
1997 Galli A, Petersen CI, deBlaquiere M, Blakely RD, DeFelice LJ. Drosophila serotonin transporters have voltage-dependent uptake coupled to a serotonin-gated ion channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3401-11. PMID 9133366 DOI: 10.1523/Jneurosci.17-10-03401.1997  0.57
1997 Apparsundaram S, Moore KR, Malone MD, Hartzell HC, Blakely RD. Molecular cloning and characterization of an L-epinephrine transporter from sympathetic ganglia of the bullfrog, Rana catesbiana. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2691-702. PMID 9092590 DOI: 10.1523/Jneurosci.17-08-02691.1997  0.399
1997 Qian Y, Galli A, Ramamoorthy S, Risso S, DeFelice LJ, Blakely RD. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 45-57. PMID 8987735 DOI: 10.1523/Jneurosci.17-01-00045.1997  0.705
1996 Chang AS, Chang SM, Starnes DM, Schroeter S, Bauman AL, Blakely RD. Cloning and expression of the mouse serotonin transporter. Brain Research. Molecular Brain Research. 43: 185-92. PMID 9037532 DOI: 10.1016/S0169-328X(96)00172-6  0.82
1996 Schroeter S, Blakely RD. Drug targets in the embryo. Studies on the cocaine- and antidepressant-sensitive serotonin transporter. Annals of the New York Academy of Sciences. 801: 239-55. PMID 8959038 DOI: 10.1111/j.1749-6632.1996.tb17446.x  0.379
1996 Saltarelli MD, Bauman AL, Moore KR, Bradley CC, Blakely RD. Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Developmental Neuroscience. 18: 524-34. PMID 8940628 DOI: 10.1159/000111450  0.805
1996 Barker EL, Blakely RD. Identification of a single amino acid, phenylalanine 586, that is responsible for high affinity interactions of tricyclic antidepressants with the human serotonin transporter. Molecular Pharmacology. 50: 957-65. PMID 8863842  0.696
1996 Tamir H, Hsiung SC, Liu KP, Blakely RD, Russo AF, Clark MS, Nunez EA, Gershon MD. Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells. Endocrinology. 137: 4475-86. PMID 8828510 DOI: 10.1210/Endo.137.10.8828510  0.392
1996 Burnette WB, Bailey MD, Kukoyi S, Blakely RD, Trowbridge CG, Justice JB. Human norepinephrine transporter kinetics using rotating disk electrode voltammetry. Analytical Chemistry. 68: 2932-8. PMID 8794928 DOI: 10.1021/ac960022x  0.443
1996 DeFelice LJ, Blakely RD. Pore models for transporters? Biophysical Journal. 70: 579-80. PMID 8789077 DOI: 10.1016/S0006-3495(96)79604-2  0.392
1996 Kelsoe JR, Remick RA, Sadovnick AD, Kristbjarnarson H, Flodman P, Spence MA, Morison M, Mroczkowski-Parker Z, Bergesch P, Rapaport MH, Mirow AL, Blakely RD, Helgason T, Egeland JA. Genetic linkage study of bipolar disorder and the serotonin transporter. American Journal of Medical Genetics. 67: 215-7. PMID 8723051 DOI: 10.1002/(Sici)1096-8628(19960409)67:2<215::Aid-Ajmg14>3.0.Co;2-M  0.428
1996 Galli A, Blakely RD, DeFelice LJ. Norepinephrine transporters have channel modes of conduction. Proceedings of the National Academy of Sciences of the United States of America. 93: 8671-6. PMID 8710929 DOI: 10.1073/Pnas.93.16.8671  0.534
1996 Melikian HE, Ramamoorthy S, Tate CG, Blakely RD. Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition. Molecular Pharmacology. 50: 266-76. PMID 8700133  0.738
1996 Gu HH, Ahn J, Caplan MJ, Blakely RD, Levey AI, Rudnick G. Cell-specific sorting of biogenic amine transporters expressed in epithelial cells. The Journal of Biological Chemistry. 271: 18100-6. PMID 8663573 DOI: 10.1074/Jbc.271.30.18100  0.475
1996 Fremeau RT, Velaz-Faircloth M, Miller JW, Henzi VA, Cohen SM, Nadler JV, Shafqat S, Blakely RD, Domin B. A novel nonopioid action of enkephalins: competitive inhibition of the mammalian brain high affinity L-proline transporter. Molecular Pharmacology. 49: 1033-41. PMID 8649341  0.302
1996 Wade PR, Chen J, Jaffe B, Kassem IS, Blakely RD, Gershon MD. Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2352-64. PMID 8601815 DOI: 10.1523/Jneurosci.16-07-02352.1996  0.427
1996 Peng L, Sokoloff L, Takahashi S, Gotoh J, Driscoll BF, Law MJ, Holtzman D, Mulkern R, Tsuji M, Cook C, Meyers R, Kaldis P, Hemmer W, Zanolla E, Wallimann T, ... ... Blakely RD, et al. Subject Index Vol. 18, 1996 Developmental Neuroscience. 18: 557-558. DOI: 10.1159/000111454  0.719
1995 Qian Y, Melikian HE, Rye DB, Levey AI, Blakely RD. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1261-74. PMID 7869097 DOI: 10.1523/Jneurosci.15-02-01261.1995  0.807
1995 Galli A, DeFelice LJ, Duke BJ, Moore KR, Blakely RD. Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants. The Journal of Experimental Biology. 198: 2197-212. PMID 7500004  0.545
1994 Demchyshyn LL, Pristupa ZB, Sugamori KS, Barker EL, Blakely RD, Wolfgang WJ, Forte MA, Niznik HB. Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 91: 5158-62. PMID 8197200 DOI: 10.1073/Pnas.91.11.5158  0.754
1994 Austin MC, Bradley CC, Mann JJ, Blakely RD. Expression of serotonin transporter messenger RNA in the human brain. Journal of Neurochemistry. 62: 2362-7. PMID 8189241 DOI: 10.1046/J.1471-4159.1994.62062362.X  0.619
1994 Melikian HE, McDonald JK, Gu H, Rudnick G, Moore KR, Blakely RD. Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody. The Journal of Biological Chemistry. 269: 12290-7. PMID 8163533  0.734
1994 Pitt BR, Weng W, Steve AR, Blakely RD, Reynolds I, Davies P. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. The American Journal of Physiology. 266: L178-86. PMID 8141313 DOI: 10.1152/Ajplung.1994.266.2.L178  0.391
1994 Ramamoorthy S, Leibach FH, Mahesh VB, Han H, Yang-Feng T, Blakely RD, Ganapathy V. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. The Biochemical Journal. 300: 893-900. PMID 8010975 DOI: 10.1042/Bj3000893  0.425
1994 Barker EL, Kimmel HL, Blakely RD. Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands. Molecular Pharmacology. 46: 799-807. PMID 7969065  0.711
1994 Moore KR, Blakely RD. Restriction site-independent formation of chimeras from homologous neurotransmitter-transporter cDNAs. Biotechniques. 17: 130-5, 137. PMID 7946295  0.365
1994 Blakely RD, De Felice LJ, Hartzell HC. Molecular physiology of norepinephrine and serotonin transporters. The Journal of Experimental Biology. 196: 263-81. PMID 7823027  0.409
1994 Tate CG, Blakely RD. The effect of N-linked glycosylation on activity of the Na(+)- and Cl(-)-dependent serotonin transporter expressed using recombinant baculovirus in insect cells. The Journal of Biological Chemistry. 269: 26303-10. PMID 7523405  0.372
1993 Blakely RD, Moore KR, Qian Y. Tails of serotonin and norepinephrine transporters: deletions and chimeras retain function. Society of General Physiologists Series. 48: 283-300. PMID 8503051  0.37
1993 Ramamoorthy S, Prasad PD, Kulanthaivel P, Leibach FH, Blakely RD, Ganapathy V. Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast. Biochemistry. 32: 1346-53. PMID 8448143 DOI: 10.1021/Bi00056A021  0.421
1993 Ramamoorthy S, Cool DR, Mahesh VB, Leibach FH, Melikian HE, Blakely RD, Ganapathy V. Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. The Journal of Biological Chemistry. 268: 21626-31. PMID 8408014  0.762
1993 Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proceedings of the National Academy of Sciences of the United States of America. 90: 2542-6. PMID 7681602 DOI: 10.1073/Pnas.90.6.2542  0.817
1993 Blakely RD. Norepinephrine and serotonin transporters: molecular insights into antidepressant targets Journal of the Neurological Sciences. 120: 2. DOI: 10.1016/0022-510X(93)90003-H  0.43
1992 Blakely RD, Berson HE. Molecular biology of serotonin receptors and transporters. Clinical Neuropharmacology. 15: 351A-352A. PMID 1498868  0.301
1992 Blakely RD. Molecular cloning and characterization of neurotransmitter transporters. Nida Research Monograph. 126: 66-83. PMID 1362795  0.301
1992 Fremeau RT, Caron MG, Blakely RD. Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain. Neuron. 8: 915-26. PMID 1350201 DOI: 10.1016/0896-6273(92)90206-S  0.418
1992 Blakely RD. Advances in molecular biology of neurotransmitter transporters Current Opinion in Psychiatry. 5: 69-73. DOI: 10.1097/00001504-199202000-00016  0.468
1991 Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. 350: 350-4. PMID 2008212 DOI: 10.1038/350350a0  0.675
1991 Blakely RD, Berson HE, Fremeau RT, Caron MG, Peek MM, Prince HK, Bradley CC. Cloning and expression of a functional serotonin transporter from rat brain. Nature. 354: 66-70. PMID 1944572 DOI: 10.1038/354066a0  0.658
1991 Blakely RD, Clark JA, Rudnick G, Amara SG. Vaccinia-T7 RNA polymerase expression system: evaluation for the expression cloning of plasma membrane transporters. Analytical Biochemistry. 194: 302-8. PMID 1862934 DOI: 10.1016/0003-2697(91)90233-J  0.637
1991 Blakely RD, Clark JA, Pacholczyk T, Amara SG. Distinct, developmentally regulated brain mRNAs direct the synthesis of neurotransmitter transporters. Journal of Neurochemistry. 56: 860-71. PMID 1671586 DOI: 10.1111/j.1471-4159.1991.tb02002.x  0.639
1990 Pacholczyk T, Blakely RD, Amara SG. A device to rapidly core out tissue culture plates for autoradiographic visualization of cells transfected with cDNA libraries. Biotechniques. 9: 556, 558. PMID 2268421  0.449
1988 Guarda AS, Robinson MB, Ory-Lavollée L, Forloni GL, Blakely RD, Coyle JT. Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay. Brain Research. 427: 223-31. PMID 3401700 DOI: 10.1016/0169-328X(88)90045-9  0.45
1988 Blakely RD, Robinson MB, Thompson RC, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate: subcellular and regional distribution, ontogeny, and the effect of lesions on N-acetylated-alpha-linked acidic dipeptidase activity. Journal of Neurochemistry. 50: 1200-9. PMID 3346674 DOI: 10.1111/J.1471-4159.1988.Tb10593.X  0.506
1988 Blakely RD, Coyle JT. The neurobiology of N-acetylaspartylglutamate. International Review of Neurobiology. 30: 39-100. PMID 3061970 DOI: 10.1016/S0074-7742(08)60046-X  0.46
1988 Blakely RD, Robinson MB, Amara SG. Expression of neurotransmitter transport from rat brain mRNA in Xenopus laevis oocytes. Proceedings of the National Academy of Sciences of the United States of America. 85: 9846-50. PMID 2904681 DOI: 10.1073/Pnas.85.24.9846  0.625
1988 Blakely RD, Robinson MB, Guarda AS, Coyle JT. A re-examination of the interaction of N-acetyl-L-aspartyl-L-glutamate with a subpopulation of rat brain membrane L-[3H]glutamate binding sites. European Journal of Pharmacology. 151: 419-26. PMID 2850921 DOI: 10.1016/0014-2999(88)90538-9  0.466
1987 Blakely RD, Ory-Lavollée L, Coyle JT. Specific alterations in the levels of N-acetyl-aspartyl-glutamate in the nervous system of the dystrophic mouse. Neuroscience Letters. 79: 223-8. PMID 3670731 DOI: 10.1016/0304-3940(87)90701-4  0.463
1987 Robinson MB, Blakely RD, Couto R, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. The Journal of Biological Chemistry. 262: 14498-506. PMID 3667587  0.377
1987 Ory-Lavollée L, Blakely RD, Coyle JT. Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. Journal of Neurochemistry. 48: 895-9. PMID 3543223 DOI: 10.1111/J.1471-4159.1987.Tb05601.X  0.436
1987 Forloni G, Grzanna R, Blakely RD, Coyle JT. Co-localization of N-acetyl-aspartyl-glutamate in central cholinergic, noradrenergic, and serotonergic neurons. Synapse (New York, N.Y.). 1: 455-60. PMID 3505373 DOI: 10.1002/syn.890010509  0.502
1987 Blakely RD, Ory-Lavollée L, Grzanna R, Koller KJ, Coyle JT. Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamate. Brain Research. 402: 373-8. PMID 2435366 DOI: 10.1016/0006-8993(87)90049-7  0.454
1986 Robinson MB, Blakely RD, Coyle JT. Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro. European Journal of Pharmacology. 130: 345-7. PMID 3539626 DOI: 10.1016/0014-2999(86)90291-8  0.419
1986 Coyle JT, Blakely R, Zaczek R, Koller KJ, Abreu M, Ory-Lavollée L, Fisher R, ffrench-Mullen JM, Carpenter DO. Acidic peptides in brain: do they act at putative glutamatergic synapses? Advances in Experimental Medicine and Biology. 203: 375-84. PMID 2878566 DOI: 10.1007/978-1-4684-7971-3_28  0.47
1986 Blakely RD, Ory-Lavollée L, Thompson RC, Coyle JT. Synaptosomal transport of radiolabel from N-acetyl-aspartyl-[3H]glutamate suggests a mechanism of inactivation of an excitatory neuropeptide. Journal of Neurochemistry. 47: 1013-9. PMID 2875126 DOI: 10.1111/J.1471-4159.1986.Tb00714.X  0.522
1984 Blakely RD, Wages SA, Justice JB, Herndon JG, Neill DB. Neuroleptics increase striatal catecholamine metabolites but not ascorbic acid in dialyzed perfusate. Brain Research. 308: 1-8. PMID 6206916 DOI: 10.1016/0006-8993(84)90910-7  0.317
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