| Year |
Citation |
Score |
| 2018 |
Richards JS, Ascoli M. Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation. Trends in Endocrinology and Metabolism: Tem. PMID 29602523 DOI: 10.1016/J.Tem.2018.02.012 |
0.394 |
|
| 2017 |
Kapfhamer J, Waite C, Ascoli M. The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C. Molecular and Cellular Endocrinology. PMID 29107092 DOI: 10.1016/J.Mce.2017.10.012 |
0.349 |
|
| 2016 |
Waite C, Mejia R, Ascoli M. Gq/11-Dependent Changes in the Murine Ovarian Transcriptome at the End of Gestation. Biology of Reproduction. PMID 26843449 DOI: 10.1095/Biolreprod.115.136952 |
0.344 |
|
| 2015 |
Mejia R, Waite C, Ascoli M. Activation of Gq/11 in the mouse corpus luteum is required for parturition. Molecular Endocrinology (Baltimore, Md.). 29: 238-46. PMID 25495873 DOI: 10.1210/Me.2014-1324 |
0.425 |
|
| 2013 |
Breen SM, Andric N, Ping T, Xie F, Offermans S, Gossen JA, Ascoli M. Ovulation involves the luteinizing hormone- dependent activation of Gq/11 in granulosa cells Molecular Endocrinology. 27: 1483-1491. PMID 23836924 DOI: 10.1210/Me.2013-1130 |
0.348 |
|
| 2013 |
Matzkin ME, Yamashita S, Ascoli M. The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells. Molecular and Cellular Endocrinology. 370: 130-7. PMID 23480967 DOI: 10.1016/J.Mce.2013.02.017 |
0.307 |
|
| 2011 |
Yamashita S, Tai P, Charron J, Ko C, Ascoli M. The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility. Molecular Endocrinology (Baltimore, Md.). 25: 1211-22. PMID 21527500 DOI: 10.1210/Me.2011-0059 |
0.34 |
|
| 2011 |
Tai P, Ascoli M. Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1/2 in Leydig cells. Molecular Endocrinology (Baltimore, Md.). 25: 885-93. PMID 21330403 DOI: 10.1210/Me.2010-0489 |
0.342 |
|
| 2010 |
Andric N, Thomas M, Ascoli M. Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo. Molecular Endocrinology (Baltimore, Md.). 24: 552-60. PMID 20093417 DOI: 10.1210/Me.2009-0450 |
0.488 |
|
| 2009 |
Tai P, Shiraishi K, Ascoli M. Activation of the lutropin/choriogonadotropin receptor inhibits apoptosis of immature Leydig cells in primary culture Endocrinology. 150: 3766-3773. PMID 19406941 DOI: 10.1210/En.2009-0207 |
0.446 |
|
| 2008 |
Andric N, Ascoli M. The luteinizing hormone receptor-activated extracellularly regulated kinase-1/2 cascade stimulates epiregulin release from granulosa cells. Endocrinology. 149: 5549-56. PMID 18653716 DOI: 10.1210/En.2008-0618 |
0.474 |
|
| 2008 |
Galet C, Ascoli M. Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells. Cellular Signalling. 20: 1822-9. PMID 18647647 DOI: 10.1016/J.Cellsig.2008.06.005 |
0.446 |
|
| 2008 |
Andric N, Ascoli M. Mutations of the lutropin/choriogonadotropin receptor that do not activate the phosphoinositide cascade allow hCG to induce aromatase expression in immature rat granulosa cells. Molecular and Cellular Endocrinology. 285: 62-72. PMID 18313839 DOI: 10.1016/J.Mce.2008.01.018 |
0.448 |
|
| 2008 |
Shiraishi K, Ascoli M. A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells. Experimental Cell Research. 314: 25-37. PMID 17727840 DOI: 10.1016/J.Yexcr.2007.06.025 |
0.434 |
|
| 2007 |
Shiraishi K, Ascoli M. Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade. Endocrinology. 148: 3214-25. PMID 17412805 DOI: 10.1210/En.2007-0160 |
0.447 |
|
| 2006 |
Andric N, Ascoli M. A delayed gonadotropin-dependent and growth factor-mediated activation of the extracellular signal-regulated kinase 1/2 cascade negatively regulates aromatase expression in granulosa cells. Molecular Endocrinology (Baltimore, Md.). 20: 3308-20. PMID 16973759 DOI: 10.1210/Me.2006-0241 |
0.431 |
|
| 2006 |
Galet C, Ascoli M. A constitutively active mutant of the human lutropin receptor (hLHR-L457R) escapes lysosomal targeting and degradation. Molecular Endocrinology (Baltimore, Md.). 20: 2931-45. PMID 16803865 DOI: 10.1210/Me.2006-0138 |
0.489 |
|
| 2006 |
Shiraishi K, Ascoli M. Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2). Endocrinology. 147: 3419-27. PMID 16614081 DOI: 10.1210/En.2005-1478 |
0.404 |
|
| 2006 |
Mizutani T, Shiraishi K, Welsh T, Ascoli M. Activation of the lutropin/choriogonadotropin receptor in MA-10 cells leads to the tyrosine phosphorylation of the focal adhesion kinase by a pathway that involves Src family kinases. Molecular Endocrinology (Baltimore, Md.). 20: 619-30. PMID 16293639 DOI: 10.1210/Me.2005-0277 |
0.386 |
|
| 2005 |
Ascoli M. Learning new tricks from an old dog: the processing of the intracellular precursor of the luteinizing hormone receptor (LHR) into the mature cell-surface LHR is a regulated process. Endocrinology. 146: 3221-3. PMID 16009970 DOI: 10.1210/En.2005-0590 |
0.405 |
|
| 2005 |
Donadeu FX, Ascoli M. The differential effects of the gonadotropin receptors on aromatase expression in primary cultures of immature rat granulosa cells are highly dependent on the density of receptors expressed and the activation of the inositol phosphate cascade. Endocrinology. 146: 3907-16. PMID 15919743 DOI: 10.1210/En.2005-0403 |
0.469 |
|
| 2005 |
Galet C, Ascoli M. The differential binding affinities of the luteinizing hormone (LH)/choriogonadotropin receptor for LH and choriogonadotropin are dictated by different extracellular domain residues. Molecular Endocrinology (Baltimore, Md.). 19: 1263-76. PMID 15677709 DOI: 10.1210/Me.2004-0410 |
0.354 |
|
| 2004 |
Galet C, Hirakawa T, Ascoli M. The postendocytotic trafficking of the human lutropin receptor is mediated by a transferable motif consisting of the C-terminal cysteine and an upstream leucine. Molecular Endocrinology (Baltimore, Md.). 18: 434-46. PMID 14605099 DOI: 10.1210/Me.2003-0293 |
0.45 |
|
| 2003 |
Bhaskaran RS, Min L, Krishnamurthy H, Ascoli M. Studies with chimeras of the gonadotropin receptors reveal the importance of third intracellular loop threonines on the formation of the receptor/nonvisual arrestin complex. Biochemistry. 42: 13950-9. PMID 14636063 DOI: 10.1021/Bi034907W |
0.492 |
|
| 2003 |
Hirakawa T, Galet C, Kishi M, Ascoli M. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. The Journal of Biological Chemistry. 278: 49348-57. PMID 14507927 DOI: 10.1074/Jbc.M306557200 |
0.425 |
|
| 2003 |
Hirakawa T, Ascoli M. A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia. Endocrinology. 144: 3872-8. PMID 12933660 DOI: 10.1210/En.2003-0365 |
0.375 |
|
| 2003 |
Hirakawa T, Ascoli M. The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras. Molecular Endocrinology (Baltimore, Md.). 17: 2189-200. PMID 12920236 DOI: 10.1210/Me.2003-0205 |
0.404 |
|
| 2003 |
Krishnamurthy H, Kishi H, Shi M, Galet C, Bhaskaran RS, Hirakawa T, Ascoli M. Postendocytotic trafficking of the follicle-stimulating hormone (FSH)-FSH receptor complex. Molecular Endocrinology (Baltimore, Md.). 17: 2162-76. PMID 12907758 DOI: 10.1210/Me.2003-0118 |
0.504 |
|
| 2003 |
Krishnamurthy H, Galet C, Ascoli M. The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation Molecular and Cellular Endocrinology. 204: 127-140. PMID 12850288 DOI: 10.1016/S0303-7207(03)00088-1 |
0.434 |
|
| 2003 |
Galet C, Min L, Narayanan R, Kishi M, Weigel NL, Ascoli M. Identification of a transferable two-amino-acid motif (GT) present in the C-terminal tail of the human lutropin receptor that redirects internalized G protein-coupled receptors from a degradation to a recycling pathway. Molecular Endocrinology (Baltimore, Md.). 17: 411-22. PMID 12554787 DOI: 10.1210/Me.2002-0161 |
0.453 |
|
| 2002 |
Ascoli M, Fanelli F, Segaloff DL. The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocrine Reviews. 23: 141-74. PMID 11943741 DOI: 10.1210/Edrv.23.2.0462 |
0.669 |
|
| 2002 |
Kishi H, Krishnamurthy H, Galet C, Bhaskaran RS, Ascoli M. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion. The Journal of Biological Chemistry. 277: 21939-46. PMID 11934883 DOI: 10.1074/Jbc.M110894200 |
0.459 |
|
| 2002 |
Hirakawa T, Galet C, Ascoli M. MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): a novel experimental paradigm to study the functional properties of the hLHR. Endocrinology. 143: 1026-35. PMID 11861529 DOI: 10.1210/Endo.143.3.8702 |
0.471 |
|
| 2002 |
Min L, Galet C, Ascoli M. The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation. The Journal of Biological Chemistry. 277: 702-10. PMID 11696538 DOI: 10.1074/Jbc.M106082200 |
0.537 |
|
| 2001 |
Kishi M, Liu X, Hirakawa T, Reczek D, Bretscher A, Ascoli M. Identification of two distinct structural motifs that, when added to the C-terminal tail of the rat LH receptor, redirect the internalized hormone-receptor complex from a degradation to a recycling pathway Molecular Endocrinology. 15: 1624-1635. PMID 11518811 DOI: 10.1210/Mend.15.9.0698 |
0.507 |
|
| 2001 |
Li S, Liu X, Min L, Ascoli M. Mutations of the second extracellular loop of the human lutropin receptor emphasize the importance of receptor activation and de-emphasize the importance of receptor phosphorylation in agonist-induced internalization. Journal of Biological Chemistry. 276: 7968-7973. PMID 11118455 DOI: 10.1074/Jbc.M010482200 |
0.483 |
|
| 2000 |
Min L, Ascoli M. Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor Molecular Endocrinology. 14: 1797-1810. PMID 11075813 DOI: 10.1210/Mend.14.11.0555 |
0.429 |
|
| 2000 |
Kishi H, Ascoli M. Multiple Distant Amino Acid Residues Present in the Serpentine Region of the Follitropin Receptor Modulate the Rate of Agonist-induced Internalization Journal of Biological Chemistry. 275: 31030-31037. PMID 10915803 DOI: 10.1074/Jbc.M005528200 |
0.377 |
|
| 2000 |
Kishi M, Ascoli M. The C-terminal tail of the rat lutropin/choriogonadotropin (CG) receptor independently modulates human (h)CG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex. Molecular Endocrinology. 14: 926-936. PMID 10847593 DOI: 10.1210/Mend.14.6.0475 |
0.488 |
|
| 2000 |
Li S, Liu X, Ascoli M. p38 JAB1 Binds to the Intracellular Precursor of the Lutropin/Choriogonadotropin Receptor and Promotes Its Degradation Journal of Biological Chemistry. 275: 13386-13393. PMID 10788448 DOI: 10.1074/Jbc.275.18.13386 |
0.441 |
|
| 2000 |
Nakamura K, Liu X, Ascoli M. Seven Non-contiguous Intracellular Residues of the Lutropin/Choriogonadotropin Receptor Dictate the Rate of Agonist-induced Internalization and Its Sensitivity to Non-visual Arrestins Journal of Biological Chemistry. 275: 241-247. PMID 10617611 DOI: 10.1074/Jbc.275.1.241 |
0.379 |
|
| 1999 |
Nakamura K, Liu X, Ascoli M. The rate of internalization of the gonadotropin receptors is greatly affected by the origin of the extracellular domain. Journal of Biological Chemistry. 274: 25426-25432. PMID 10464272 DOI: 10.1074/Jbc.274.36.25426 |
0.469 |
|
| 1999 |
Nakamura K, Lazari MF, Li S, Korgaonkar C, Ascoli M. Role of the rate of internalization of the agonist-receptor complex on the agonist-induced down-regulation of the lutropin/choriogonadotropin receptor. Molecular Endocrinology (Baltimore, Md.). 13: 1295-304. PMID 10446904 DOI: 10.1210/Mend.13.8.0331 |
0.545 |
|
| 1999 |
Lazari MDFM, Liu X, Nakamura K, Benovic JL, Ascoli M. Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor Molecular Endocrinology. 13: 866-878. PMID 10379886 DOI: 10.1210/Mend.13.6.0289 |
0.468 |
|
| 1998 |
Min K, Liu X, Fabritz J, Jaquette J, Abell AN, Ascoli M. Mutations That Induce Constitutive Activation and Mutations That Impair Signal Transduction Modulate the Basal and/or Agonist-stimulated Internalization of the Lutropin/Choriogonadotropin Receptor Journal of Biological Chemistry. 273: 34911-34919. PMID 9857020 DOI: 10.1074/Jbc.273.52.34911 |
0.506 |
|
| 1998 |
Nakamura K, Krupnick JG, Benovic JL, Ascoli M. Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal an activation- and phosphorylation-independent but arrestin- dependent pathway for internalization Journal of Biological Chemistry. 273: 24346-24354. PMID 9733722 DOI: 10.1074/Jbc.273.38.24346 |
0.42 |
|
| 1998 |
Lazari MF, Bertrand JE, Nakamura K, Liu X, Krupnick JG, Benovic JL, Ascoli M. Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalization. The Journal of Biological Chemistry. 273: 18316-24. PMID 9660797 DOI: 10.1074/Jbc.273.29.18316 |
0.357 |
|
| 1998 |
Nakamura K, Hipkin RW, Ascoli M. The Agonist-Induced Phosphorylation of the Rat Follitropin Receptor Maps to the First and Third Intracellular Loops Molecular Endocrinology. 12: 580-591. PMID 9544993 DOI: 10.1210/Mend.12.4.0087 |
0.338 |
|
| 1998 |
Fabritz J, Ryan S, Ascoli M. Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this precursor binds choriogonadotropin with high affinity. Biochemistry. 37: 664-72. PMID 9425089 DOI: 10.1021/Bi972355+ |
0.369 |
|
| 1998 |
Ascoli M. Molecular basis of the regulation of the lutropin/choriogonadotropin receptor. Biochemical Society Transactions. 25: 1021-6. PMID 9388594 DOI: 10.1042/Bst0251021 |
0.436 |
|
| 1997 |
Wang Z, Liu X, Ascoli M. Phosphorylation of the Lutropin/Choriogonadotropin Receptor Facilitates Uncoupling of the Receptor from Adenylyl Cyclase and Endocytosis of the Bound Hormone Molecular Endocrinology. 11: 183-192. PMID 9013765 DOI: 10.1210/Mend.11.2.9889 |
0.539 |
|
| 1997 |
Ascoli M. Functional consequences of the phosphorylation of the gonadotropin receptors. Biochemical Pharmacology. 52: 1647-55. PMID 8986126 DOI: 10.1016/S0006-2952(96)00553-9 |
0.542 |
|
| 1996 |
Wang Z, Hipkin RW, Ascoli M. Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization, and enhance agonist-induced receptor down-regulation. Molecular Endocrinology. 10: 748-759. PMID 8776735 DOI: 10.1210/Mend.10.6.8776735 |
0.489 |
|
| 1996 |
Dhanwada KR, Vijapurkar U, Ascoli M. Two Mutations Of The Lutropin/Choriogonadotropin Receptor That Impair Signal Transduction Also Interfere With Receptor-Mediated Endocytosis Molecular Endocrinology. 10: 544-554. PMID 8732685 DOI: 10.1210/Mend.10.5.8732685 |
0.51 |
|
| 1995 |
Hipkin RW, Wang Z, Ascoli M. Human chorionic gonadotropin (CG)- and phorbol ester-stimulated phosphorylation of the luteinizing hormone/CG receptor maps to serines 635, 639, 649, and 652 in the C-terminal cytoplasmic tail. Molecular Endocrinology. 9: 151-158. PMID 7776965 DOI: 10.1210/Mend.9.2.7776965 |
0.511 |
|
| 1995 |
Zhu H, Wang H, Ascoli M. The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residues. Molecular Endocrinology. 9: 141-150. PMID 7776964 DOI: 10.1210/Mend.9.2.7776964 |
0.478 |
|
| 1995 |
Hipkin RW, Liu X, Ascoli M. Truncation of the C-terminal Tail of the Follitropin Receptor Does Not Impair the Agonist- or Phorbol Ester-induced Receptor Phosphorylation and Uncoupling Journal of Biological Chemistry. 270: 26683-26689. PMID 7592895 DOI: 10.1074/Jbc.270.44.26683 |
0.474 |
|
| 1995 |
Hoelscher SR, Ascoli M. Decreased stathmin expression does not affect the actions of human choriogonadotropin or epidermal growth factor in Leydig tumor cells Endocrinology. 136: 5004-5013. PMID 7588235 DOI: 10.1210/Endo.136.11.7588235 |
0.491 |
|
| 1994 |
Hoelscher SR, Ascoli M. Leydig tumor cell protein phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor is identified as stathmin Endocrinology. 135: 662-666. PMID 8033814 DOI: 10.1210/Endo.135.2.8033814 |
0.408 |
|
| 1994 |
Nelson S, Liu X, Noblett L, Fabritz J, Ascoli M. Characterization of the functional properties and nuclear binding proteins of the rat luteinizing hormone/chorionic gonadotropin receptor promoter in Leydig cells. Endocrinology. 135: 1729-1739. PMID 7956896 DOI: 10.1210/Endo.135.5.7956896 |
0.495 |
|
| 1993 |
Hoelscher SR, Ascoli M. Identification of a Leydig tumor cell protein that is phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor Endocrinology. 132: 2229-2238. PMID 8477667 DOI: 10.1210/Endo.132.5.8477667 |
0.403 |
|
| 1993 |
Sánchez-Yagüe J, Hipkin RW, Ascoli M. Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors. Endocrinology. 132: 1007-1016. PMID 8440169 DOI: 10.1210/Endo.132.3.8440169 |
0.495 |
|
| 1993 |
Hipkin RW, Sánchez-Yagüe J, Ascoli M. Agonist-induced phosphorylation of the luteinizing hormone/chorionic gonadotropin receptor expressed in a stably transfected cell line. Molecular Endocrinology. 7: 823-832. PMID 8413307 DOI: 10.1210/Mend.7.7.8413307 |
0.549 |
|
| 1993 |
Quintana J, Hipkin RW, Ascoli M. A polyclonal antibody to a synthetic peptide derived from the rat follicle-stimulating hormone receptor reveals the recombinant receptor as a 74-kilodalton protein Endocrinology. 133: 2098-2104. PMID 8404659 DOI: 10.1210/Endo.133.5.8404659 |
0.539 |
|
| 1993 |
Quintana J, Wang H, Ascoli M. The regulation of the binding affinity of the luteinizing hormone/choriogonadotropin receptor by sodium ions is mediated by a highly conserved aspartate located in the second transmembrane domain of G protein-coupled receptors. Molecular Endocrinology. 7: 767-775. PMID 8395653 DOI: 10.1210/Mend.7.6.8395653 |
0.533 |
|
| 1993 |
Wang Z, Wang H, Ascoli M. Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor. Molecular Endocrinology. 7: 85-93. PMID 8383288 DOI: 10.1210/Mend.7.1.8383288 |
0.496 |
|
| 1993 |
Stocco DM, Ascoli M. The use of genetic manipulation of MA-10 Leydig tumor cells to demonstrate the role of mitochondrial proteins in the acute regulation of steroidogenesis. Endocrinology. 132: 959-67. PMID 8382603 DOI: 10.1210/Endo.132.3.8382603 |
0.385 |
|
| 1993 |
Segaloff DL, Ascoli M. The Lutropin/Choriogonadotropin Receptor… 4 Years Later* Endocrine Reviews. 14: 324-347. PMID 8319598 DOI: 10.1210/Edrv-14-3-324 |
0.695 |
|
| 1992 |
Hipkin RW, Sánchez-Yagüe J, Ascoli M. Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA. Molecular Endocrinology. 6: 2210-2218. PMID 1491699 DOI: 10.1210/Mend.6.12.1491699 |
0.539 |
|
| 1992 |
Nelson S, Ascoli M. Epidermal growth factor, a phorbol ester, and 3',5'-cyclic adenosine monophosphate decrease the transcription of the luteinizing hormone/chorionic gonadotropin receptor gene in MA-10 leydig tumor cells Endocrinology. 131: 615-620. PMID 1322276 DOI: 10.1210/Endo.131.2.1322276 |
0.536 |
|
| 1992 |
Wang H, Nelson S, Ascoli M, Segaloff DL. The 5'-flanking region of the rat luteinizing hormone/chorionic gonadotropin receptor gene confers Leydig cell expression and negative regulation of gene transcription by 3',5'-cyclic adenosine monophosphate. Molecular Endocrinology (Baltimore, Md.). 6: 320-6. PMID 1316538 DOI: 10.1210/Mend.6.3.1316538 |
0.731 |
|
| 1991 |
Wang H, Ascoli M, Segaloff DL. Multiple luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid transcripts. Endocrinology. 129: 133-8. PMID 2055178 DOI: 10.1210/Endo-129-1-133 |
0.723 |
|
| 1991 |
Wang H, Segaloff DL, Ascoli M. Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor. Endocrinology. 128: 2651-3. PMID 2019271 DOI: 10.1210/Endo-128-5-2651 |
0.726 |
|
| 1991 |
Hoelscher SR, Sairam MR, Ascoli M. The slow rate of internalization of deglycosylated human chorionic gonadotropin is not due to its inability of stimulate cyclic adenosine monophosphate accumulation Endocrinology. 128: 2837-2843. PMID 1645252 DOI: 10.1210/Endo-128-6-2837 |
0.479 |
|
| 1990 |
Segaloff DL, Sprengel R, Nikolics K, Ascoli M. Structure of the lutropin/choriogonadotropin receptor. Recent Progress in Hormone Research. 46: 261-301; discussion . PMID 2281186 DOI: 10.1016/B978-0-12-571146-3.50014-6 |
0.716 |
|
| 1990 |
Pignataro OP, Ascoli M. Studies with Insulin and Insulin-Like Growth Factor-I Show that the Increased Labeling of Phosphatidylinositol-3,4-Bisphosphate Is not Sufficient to Elicit the Diverse Actions of Epidermal Growth Factor on MA-10 Leydig Tumor Cells Molecular Endocrinology. 4: 758-765. PMID 2177144 DOI: 10.1210/Mend-4-5-758 |
0.351 |
|
| 1990 |
Hafez MM, Ascoli M. Epidermal Growth Factor Desensitizes the Gonadotropin-Responsive Adenylyl Cyclase in Membranes Isolated from MA-10 Ley dig Tumor Cells and Luteinized Rat Ovaries* Endocrinology. 127: 394-402. PMID 2163321 DOI: 10.1210/Endo-127-1-394 |
0.409 |
|
| 1990 |
Wang H, Ascoli M. Reduced Gonadotropin Responses in a Novel Clonal Strain of Leydig Tumor Cells Established by Transfection of MA-10 Cells with a Mutant Gene of the Type I Regulatory Subunit of the cAMPDependent Protein Kinase Molecular Endocrinology. 4: 80-90. PMID 2157978 DOI: 10.1210/Mend-4-1-80 |
0.429 |
|
| 1990 |
Miller ES, Ascoli M. Anti-phosphotyrosine immunoprecipitation of phosphatidylinositol 3' kinase activity in different cell types after exposure to epidermal growth factor. Biochemical and Biophysical Research Communications. 173: 289-295. PMID 1701636 DOI: 10.1016/S0006-291X(05)81055-1 |
0.341 |
|
| 1989 |
Ascoli M, Segaloff DL. On the Structure of the Luteinizing Hormone/Chorionic Gonadotropin Receptor* Endocrine Reviews. 10: 27-44. PMID 2666109 DOI: 10.1210/Edrv-10-1-27 |
0.698 |
|
| 1989 |
Ascoli M, Segaloff DL. Regulation of the differentiated functions of Leydig tumor cells by epidermal growth factor. Annals of the New York Academy of Sciences. 564: 99-115. PMID 2549837 DOI: 10.1111/J.1749-6632.1989.Tb25891.X |
0.671 |
|
| 1988 |
Rosemblit N, Ascoli M, Segaloff DL. Characterization of an antiserum to the rat luteal luteinizing hormone/chorionic gonadotropin receptor. Endocrinology. 123: 2284-2290. PMID 3168924 DOI: 10.1210/Endo-123-5-2284 |
0.671 |
|
| 1988 |
Pereira ME, Segaloff DL, Ascoli M. Ca+2 Is an Inhibitor of Adenylate Cyclase in MA-10 Leydig Tumor Cells* Endocrinology. 122: 2232-2239. PMID 2834186 DOI: 10.1210/Endo-122-5-2232 |
0.6 |
|
| 1988 |
Segaloff DL, Ascoli M. Chapter 9 Internalization of peptide hormones and hormone receptors New Comprehensive Biochemistry. 18: 133-149. DOI: 10.1016/S0167-7306(08)60644-4 |
0.706 |
|
| 1987 |
Ascoli M, Segaloff DL. On the Fates of Receptor-Bound Ovine Luteinizing Hormone and Human Chorionic Gonadotropin in Cultured Leydig Tumor Cells. Demonstration of Similar Rates of Internalization Endocrinology. 120: 1161-1172. PMID 3803314 DOI: 10.1210/Endo-120-3-1161 |
0.683 |
|
| 1985 |
Pandey KN, Ascoli M, Inagami T. Induction of Renin Activity by Gonadotropic Hormones in Cultured Leydig Tumor Cells Endocrinology. 117: 2120-2126. PMID 2412804 DOI: 10.1210/Endo-117-5-2120 |
0.401 |
|
| 1984 |
Ascoli M. Lysosomal accumulation of the hormone-receptor complex during receptor-mediated endocytosis of human choriogonadotropin. Journal of Cell Biology. 99: 1242-1250. PMID 6090468 DOI: 10.1083/Jcb.99.4.1242 |
0.519 |
|
| 1983 |
Ascoli M, Freeman DA, Sheets JJ, Vickery LE. Inhibition of steroidogenesis in cultured Leydig tumor cells by 22-amino-23,24-bisnor-5-cholen-3 beta-O1 and (20R) 20-phenyl-5-pregnene-3 beta,20-diol. Endocrinology. 113: 127-32. PMID 6683151 DOI: 10.1210/Endo-113-1-127 |
0.312 |
|
| 1983 |
Freeman DA, Ascoli M. The low-density lipoprotein pathway of cultured Leydig tumor cells. Utilization of low-density lipoprotein-derived cholesterol for steroidogenesis. Biochimica Et Biophysica Acta. 754: 72-81. PMID 6626568 DOI: 10.1016/0005-2760(83)90083-8 |
0.301 |
|
| 1983 |
Ascoli M. An improved method for the solubilization of stable gonadotropin receptors. Endocrinology. 113: 2129-2134. PMID 6315342 DOI: 10.1210/Endo-113-6-2129 |
0.524 |
|
| 1983 |
Lloyd CE, Ascoli M. On the mechanisms involved in the regulation of the cell-surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells. Journal of Cell Biology. 96: 521-526. PMID 6300136 DOI: 10.1083/Jcb.96.2.521 |
0.504 |
|
| 1982 |
Freeman DA, Ascoli M. Desensitization of steroidogenesis in cultured Leydig tumor cells: role of cholesterol. Proceedings of the National Academy of Sciences of the United States of America. 79: 7796-800. PMID 6296852 DOI: 10.1073/Pnas.79.24.7796 |
0.44 |
|
| 1982 |
Ascoli M. Receptor‐Mediated Uptake And Degradation Of Human Chorionic Gonadotropin: Fate Of The Hormone Subunits* Annals of the New York Academy of Sciences. 383: 151-173. PMID 6283988 DOI: 10.1111/J.1749-6632.1982.Tb23167.X |
0.341 |
|
| 1981 |
Bahn RS, Worsham A, Speeg KV, Ascoli M, Rabin D. Characterization of steroid production in cultured human choriocarcinoma cells The Journal of Clinical Endocrinology and Metabolism. 52: 447-450. PMID 6970203 DOI: 10.1210/Jcem-52-3-447 |
0.326 |
|
| 1981 |
Segaloff DL, Ascoli M, Puett D. Characterization of the desensitized state of Leydig tumor cells. Biochimica Et Biophysica Acta. 675: 351-358. PMID 6268190 DOI: 10.1016/0304-4165(81)90025-8 |
0.636 |
|
| 1981 |
Ascoli M. Characterization of Several Clonal Lines of Cultured Ley dig Tumor Cells: Gonadotropin Receptors and Steroidogenic Responses* Endocrinology. 108: 88-95. PMID 6257492 DOI: 10.1210/Endo-108-1-88 |
0.474 |
|
| 1981 |
Segaloff DL, Puett D, Ascoli M. The Dynamics of the Steroidogenic Response of Perifused Leydig Tumor Cells to Human Chorionic Gonadotropin, Ovine Luteinizing Hormone, Cholera Toxin, and Adenosine 3′,5′-Cyclic Monophosphate* Endocrinology. 108: 632-638. PMID 6256160 DOI: 10.1210/Endo-108-2-632 |
0.638 |
|
| 1980 |
Bahn RS, Speeg KV, Ascoli M, Rabin D. Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells Endocrinology. 107: 2121-2123. PMID 6968677 DOI: 10.1210/Endo-107-6-2121 |
0.374 |
|
| 1980 |
Ascoli M. Degradation of the subunits of receptor-bound human choriogonadotropin by Leydig tumor cells Biochimica Et Biophysica Acta. 629: 409-417. PMID 6248122 DOI: 10.1016/0304-4165(80)90113-0 |
0.382 |
|
| 1979 |
Lacroix A, Ascoli M, Puett D, McKenna TJ. Steroidogenesis in HCG-responsive Leydig cell tumor variants Journal of Steroid Biochemistry. 10: 669-675. PMID 314019 DOI: 10.1016/0022-4731(79)90520-X |
0.385 |
|
| 1979 |
Ascoli M. Inhibition of the degradation of receptor-bound human choriogonadotropin by leupeptin Biochimica Et Biophysica Acta. 586: 608-614. PMID 224947 DOI: 10.1016/0304-4165(79)90051-5 |
0.469 |
|
| 1978 |
Ascoli M, Puett D. Gonadotropin binding and stimulation of steroidogenesis in Leydig tumor cells Proceedings of the National Academy of Sciences of the United States of America. 75: 99-102. PMID 203945 DOI: 10.1073/Pnas.75.1.99 |
0.395 |
|
| 1976 |
Ascoli M, Puett D. Biotransformations of pituitary luteinizing hormone in serum and urine. II. Evidence for reduced potency following urinary excretion. Endocrinology. 99: 1237-1243. PMID 991818 DOI: 10.1210/Endo-99-5-1237 |
0.315 |
|
| 1976 |
Ascoli M, Puett D. Biotransformations of Pituitary Luteinizing Hormone in Serum and Urine. I. Association with Serum Components1 Endocrinology. 99: 1229-1236. PMID 991817 DOI: 10.1210/Endo-99-5-1229 |
0.355 |
|
| 1976 |
Ascoli M, Liddle RA, Puett D. Renal and hepatic lysosomal catabolism of luteinizing hormone Molecular and Cellular Endocrinology. 4: 297-310. PMID 950069 DOI: 10.1016/0303-7207(76)90047-2 |
0.341 |
|
| 1975 |
Ascoli M, Liddle RA, Puett D. The metabolism of luteinizing hormone. plasma clearance, urinary excretion, and tissue uptake ☆ Molecular and Cellular Endocrinology. 3: 21-36. PMID 168103 DOI: 10.1016/0303-7207(75)90029-5 |
0.317 |
|
| 1974 |
Ascoli M, Puett D. Tritium labeling of luteinizing hormone by reductive methylation Biochimica Et Biophysica Acta. 371: 203-210. PMID 4371854 DOI: 10.1016/0005-2795(74)90169-X |
0.339 |
|
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