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William C. Hahn, M.D., Ph.D. - Publications

Affiliations: 
Molecular and Cellular Oncology, Medical Oncology Harvard Medical School, Dana Farber Cancer Institute, Broad Institute of Harvard and MIT, 
Area:
EGFR , RNAi
Website:
http://research4.dfci.harvard.edu/hahnlab//index.html
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Year Citation  Score
2023 Schaefer A, Hodge RG, Zhang H, Hobbs GA, Dilly J, Huynh MV, Goodwin CM, Zhang F, Diehl JN, Pierobon M, Baldelli E, Javaid S, Guthrie K, Rashid NU, Petricoin EF, ... ... Hahn WC, et al. RHOA drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling. Science Signaling. 16: eadg5289. PMID 38113333 DOI: 10.1126/scisignal.adg5289  0.551
2023 Krill-Burger JM, Dempster JM, Borah AA, Paolella BR, Root DE, Golub TR, Boehm JS, Hahn WC, McFarland JM, Vazquez F, Tsherniak A. Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal. Genome Biology. 24: 192. PMID 37612728 DOI: 10.1186/s13059-023-03020-w  0.379
2023 de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, Matthews GM, Barwick BG, Gupta VA, Dupéré-Richer D, Yamano S, Hu Y, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Ishiguro K, Meyers RM, ... ... Hahn WC, et al. Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature Cancer. 4: 754-773. PMID 37237081 DOI: 10.1038/s43018-023-00550-x  0.552
2023 Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, ... Hahn WC, et al. USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Cell Reports. Medicine. 101007. PMID 37030295 DOI: 10.1016/j.xcrm.2023.101007  0.538
2023 Sharifnia T, Wawer MJ, Goodale A, Lee Y, Kazachkova M, Dempster JM, Muller S, Levy J, Freed DM, Sommer J, Kalfon J, Vazquez F, Hahn WC, Root DE, Clemons PA, et al. Mapping the landscape of genetic dependencies in chordoma. Nature Communications. 14: 1933. PMID 37024492 DOI: 10.1038/s41467-023-37593-8  0.35
2023 Bala P, Rennhack JP, Aitymbayev D, Morris C, Moyer SM, Duronio GN, Doan P, Li Z, Liang X, Hornick JL, Yurgelun MB, Hahn WC, Sethi NS. Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation. Science Advances. 9: eadf0927. PMID 36989360 DOI: 10.1126/sciadv.adf0927  0.344
2022 Cervia LD, Shibue T, Borah AA, Gaeta B, He L, Leung L, Li N, Moyer SM, Shim BH, Dumont N, Gonzalez A, Bick NR, Kazachkova M, Dempster JM, Krill-Burger JM, ... ... Hahn WC, et al. A ubiquitination cascade regulating the integrated stress response and survival in carcinomas. Cancer Discovery. PMID 36576405 DOI: 10.1158/2159-8290.CD-22-1230  0.369
2022 Schröfelbauer B, Kimes PK, Hauke P, Reid CE, Shao K, Hill SJ, Irizarry R, Hahn WC. Discovery of antibodies and cognate surface targets for ovarian cancer by surface profiling. Proceedings of the National Academy of Sciences of the United States of America. 120: e2206751120. PMID 36574667 DOI: 10.1073/pnas.2206751120  0.318
2022 Hagel KR, Arafeh R, Gang S, Arnoff TE, Larson RC, Doench JG, Mathewson ND, Wucherpfennig KW, Maus MV, Hahn WC. Systematic interrogation of tumor cell resistance to CAR T cell therapy in pancreatic cancer. Cancer Research. PMID 36548402 DOI: 10.1158/0008-5472.CAN-22-2245  0.305
2022 Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, ... ... Hahn WC, et al. Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity. Cancer Research. PMID 36459568 DOI: 10.1158/0008-5472.CAN-22-3050  0.553
2022 Ursu O, Neal JT, Shea E, Thakore PI, Jerby-Arnon L, Nguyen L, Dionne D, Diaz C, Bauman J, Mosaad MM, Fagre C, Lo A, McSharry M, Giacomelli AO, Ly SH, ... ... Hahn WC, et al. Author Correction: Massively parallel phenotyping of coding variants in cancer with Perturb-seq. Nature Biotechnology. 40: 1691. PMID 36258042 DOI: 10.1038/s41587-022-01495-9  0.517
2022 So J, Mabe NW, Englinger B, Chow KH, Moyer SM, Yerrum S, Trissal MC, Graca Marques J, Kwon JJ, Shim BH, Pal S, Panditharatna E, Quinn TW, Schaefer DA, Jeong D, ... ... Hahn WC, et al. VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system. Jci Insight. PMID 36040810 DOI: 10.1172/jci.insight.158755  0.358
2022 Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, ... ... Hahn WC, et al. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. PMID 35831509 DOI: 10.1038/s41586-022-04928-2  0.49
2022 Bondeson DP, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Langan C, Mesa G, Gonzalez A, Surface LE, Ito K, Kazachkova M, Colgan WN, Warren A, Dempster JM, Krill-Burger JM, ... ... Hahn WC, et al. Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nature Cancer. PMID 35437317 DOI: 10.1038/s43018-022-00360-7  0.398
2022 Gannon HS, Zou T, Kiessling MK, Gao GF, Cai D, Choi PS, Ivan AP, Buchumenski I, Berger AC, Goldstein JT, Cherniack AD, Vazquez F, Tsherniak A, Levanon EY, Hahn WC, et al. Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nature Communications. 13: 1894. PMID 35365656 DOI: 10.1038/s41467-022-29467-2  0.514
2022 Ursu O, Neal JT, Shea E, Thakore PI, Jerby-Arnon L, Nguyen L, Dionne D, Diaz C, Bauman J, Mosaad MM, Fagre C, Lo A, McSharry M, Giacomelli AO, Ly SH, ... ... Hahn WC, et al. Massively parallel phenotyping of coding variants in cancer with Perturb-seq. Nature Biotechnology. PMID 35058622 DOI: 10.1038/s41587-021-01160-7  0.569
2021 Kim M, Ly SH, Xie Y, Duronio GN, Ford-Roshon D, Hwang JH, Sulahian R, Rennhack JP, So J, Gjoerup O, Talamas JA, Grandclaudon M, Long HW, Doench JG, Sethi NS, ... ... Hahn WC, et al. YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. Developmental Cell. PMID 34990589 DOI: 10.1016/j.devcel.2021.12.006  0.375
2021 Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, ... ... Hahn WC, et al. Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer. Cell. 184: 6119-6137.e26. PMID 34890551 DOI: 10.1016/j.cell.2021.11.017  0.64
2021 Dai C, Rennhack JP, Arnoff TE, Thaker M, Younger ST, Doench JG, Huang AY, Yang A, Aguirre AJ, Wang B, Mun E, O'Connell JT, Huang Y, Labella K, Talamas JA, ... ... Hahn WC, et al. SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell Reports. 36: 109443. PMID 34320363 DOI: 10.1016/j.celrep.2021.109443  0.757
2021 Tan KT, Kim H, Carrot-Zhang J, Zhang Y, Kim WJ, Kugener G, Wala JA, Howard TP, Chi YY, Beroukhim R, Li H, Ha G, Alper SL, Perlman EJ, Mullen EA, ... Hahn WC, et al. Haplotype-resolved germline and somatic alterations in renal medullary carcinomas. Genome Medicine. 13: 114. PMID 34261517 DOI: 10.1186/s13073-021-00929-4  0.679
2021 Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, ... ... Hahn WC, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Reports. 36: 109367. PMID 34260938 DOI: 10.1016/j.celrep.2021.109367  0.736
2021 Waters AM, Khatib TO, Papke B, Goodwin CM, Hobbs GA, Diehl JN, Yang R, Edwards AC, Walsh KH, Sulahian R, McFarland JM, Kapner KS, Gilbert TSK, Stalnecker CA, Javaid S, ... ... Hahn WC, et al. Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Reports. 35: 109291. PMID 34192548 DOI: 10.1016/j.celrep.2021.109291  0.71
2021 Cleary JM, Raghavan S, Wu Q, Li YY, Spurr LF, Gupta HV, Rubinson DA, Fetter IJ, Hornick JL, Nowak JA, Siravegna G, Goyal L, Shi L, Brais LK, Loftus M, ... ... Hahn WC, et al. FGFR2 Extracellular Domain In-Frame Deletions are Therapeutically Targetable Genomic Alterations that Function as Oncogenic Drivers in Cholangiocarcinoma. Cancer Discovery. PMID 33926920 DOI: 10.1158/2159-8290.CD-20-1669  0.482
2021 Dharia NV, Kugener G, Guenther LM, Malone CF, Durbin AD, Hong AL, Howard TP, Bandopadhayay P, Wechsler CS, Fung I, Warren AC, Dempster JM, Krill-Burger JM, Paolella BR, Moh P, ... ... Hahn WC, et al. A first-generation pediatric cancer dependency map. Nature Genetics. PMID 33753930 DOI: 10.1038/s41588-021-00819-w  0.712
2021 Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, et al. An expanded universe of cancer targets. Cell. 184: 1142-1155. PMID 33667368 DOI: 10.1016/j.cell.2021.02.020  0.422
2020 Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, ... ... Hahn WC, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Reports. 33: 108493. PMID 33326793 DOI: 10.1016/j.celrep.2020.108493  0.752
2020 Howard TP, Oberlick EM, Rees MG, Arnoff TE, Pham MN, Brenan L, DoCarmo M, Hong AL, Kugener G, Chou HC, Drosos Y, Mathias KM, Ramos P, Seashore-Ludlow B, Giacomelli AO, ... ... Hahn WC, et al. Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32631955 DOI: 10.1158/1078-0432.Ccr-19-2717  0.688
2020 Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, ... ... Hahn WC, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nature Chemical Biology. PMID 32251410 DOI: 10.1038/S41589-020-0506-0  0.599
2020 Schauer NJ, Liu X, Magin RS, Doherty LM, Chan WC, Ficarro SB, Hu W, Roberts RM, Iacob RE, Stolte B, Giacomelli AO, Perera S, McKay K, Boswell SA, Weisberg EL, ... ... Hahn WC, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Scientific Reports. 10: 5324. PMID 32210275 DOI: 10.1038/S41598-020-62076-X  0.482
2020 Rafiei S, Fitzpatrick K, Liu D, Cai MY, Elmarakeby HA, Park J, Ricker C, Kochupurakkal BS, Choudhury AD, Hahn WC, Balk SP, Hwang JH, Van Allen EM, Mouw KW. ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer. Cancer Research. PMID 32127357 DOI: 10.1158/0008-5472.Can-19-3126  0.395
2020 Kim JW, Berrios C, Kim M, Schade AE, Adelmant G, Yeerna H, Damato E, Iniguez AB, Florens L, Washburn MP, Stegmaier K, Gray NS, Tamayo P, Gjoerup O, Marto JA, ... ... Hahn WC, et al. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. Elife. 9. PMID 31913126 DOI: 10.7554/Elife.53003  0.359
2020 Kim JW, Berrios C, Kim M, Schade AE, Adelmant G, Yeerna H, Damato E, Iniguez AB, Florens L, Washburn MP, Stegmaier K, Gray NS, Tamayo P, Gjoerup O, Marto JA, ... ... Hahn WC, et al. Author response: STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells Elife. DOI: 10.7554/Elife.53003.Sa2  0.314
2020 Cleary JM, Raghavan S, Li YY, Spurr L, Wu Q, Shi L, Brais LK, Odhiambo Z, Goyal L, Patel AK, Shinagare AB, Clancy TE, Shapiro G, Cerami E, Sellers WR, ... Hahn WC, et al. Therapeutic targeting of extracellular FGFR2 activating deletions in intrahepatic cholangiocarcinoma. Journal of Clinical Oncology. 38: 567-567. DOI: 10.1200/Jco.2020.38.4_Suppl.567  0.516
2020 Hahn WC. Abstract IA28: Systematic interrogation of KRAS in cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-Ia28  0.514
2020 Durbin AD, Kugener G, Zimmerman MW, Yan C, Dharia NV, Frank ES, Chen X, Ross KN, Paolella B, Krill-Burger M, Root DE, Boehm JS, Vazquez F, Hong AL, Tsherniak A, ... ... Hahn WC, et al. Abstract B10: Rhabdomyosarcoma requires MYC family genomic events to pathogenically subvert core-regulatory circuitry Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-B10  0.724
2020 Winter PS, Raghavan S, Navia AW, Williams H, Galvez-Reyes J, Kalekar R, Borah A, DenAdel A, Raghavan M, Lowder K, Mulugeta N, Wang J, Reilly E, Brais L, Crawford L, ... ... Hahn WC, et al. Abstract PR02: Matched metastatic pancreatic ductal adenocarcinoma biopsies and organoid models reveal tumor cell transcriptional plasticity and subtype-specific microenvironmental crosstalk Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Pr02  0.626
2020 Hahn WC. Abstract IA17: Defining cancer dependency maps Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Ia17  0.523
2020 Li YY, Cleary JM, Raghavan S, Spurr LF, Wu Q, Shi L, Brais LK, Loftus M, Goyal L, Patel AK, Shinagare AB, Clancy TE, Shapiro G, Cerami E, Sellers WR, ... Hahn WC, et al. Abstract 1097: FGFR2 in-frame indels: A novel targetable alteration in intrahepatic cholangiocarcinoma Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1097  0.462
2019 Dempster JM, Pacini C, Pantel S, Behan FM, Green T, Krill-Burger J, Beaver CM, Younger ST, Zhivich V, Najgebauer H, Allen F, Gonçalves E, Shepherd R, Doench JG, Yusa K, ... ... Hahn WC, et al. Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nature Communications. 10: 5817. PMID 31862961 DOI: 10.1038/S41467-019-13805-Y  0.42
2019 Hwang JH, Seo JH, Beshiri ML, Wankowicz S, Liu D, Cheung A, Li J, Qiu X, Hong AL, Botta G, Golumb L, Richter C, So J, Sandoval GJ, Giacomelli AO, ... ... Hahn WC, et al. CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer. Cell Reports. 29: 2355-2370.e6. PMID 31747605 DOI: 10.1016/J.Celrep.2019.10.068  0.674
2019 Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, ... ... Hahn WC, et al. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Reports. 29: 118-134.e8. PMID 31577942 DOI: 10.1016/J.Celrep.2019.08.090  0.62
2019 Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, ... ... Hahn WC, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Reports. 28: 2331-2344.e8. PMID 31461650 DOI: 10.1016/J.Celrep.2019.07.021  0.493
2019 Boettcher S, Miller PG, Sharma R, McConkey M, Leventhal M, Krivtsov AV, Giacomelli AO, Wong W, Kim J, Chao S, Kurppa KJ, Yang X, Milenkowic K, Piccioni F, Root DE, ... ... Hahn WC, et al. A dominant-negative effect drives selection of missense mutations in myeloid malignancies. Science (New York, N.Y.). 365: 599-604. PMID 31395785 DOI: 10.1126/Science.Aax3649  0.543
2019 Hahn WC. A CRISPR Way to Identify Cancer Targets. The New England Journal of Medicine. 380: 2475-2477. PMID 31216404 DOI: 10.1056/Nejmcibr1905048  0.492
2019 Bandopadhayay P, Piccioni F, O'Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, ... ... Hahn WC, et al. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nature Communications. 10: 2400. PMID 31160565 DOI: 10.1038/S41467-019-10307-9  0.672
2019 Goyal L, Shi L, Liu LY, Fece de la Cruz F, Lennerz JK, Raghavan S, Leshchiner I, Elagina L, Siravegna G, Ng RWS, Vu P, Patra KC, Saha SK, Uppot RN, Arellano R, ... ... Hahn WC, et al. TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma. Cancer Discovery. PMID 31109923 DOI: 10.1158/2159-8290.Cd-19-0182  0.342
2019 Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, ... ... Hahn WC, et al. The landscape of cancer cell line metabolism. Nature Medicine. 25: 850-860. PMID 31068703 DOI: 10.1038/S41591-019-0404-8  0.447
2019 Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, ... ... Hahn WC, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. PMID 31068700 DOI: 10.1038/S41586-019-1186-3  0.476
2019 Wang X, Wang S, Troisi EC, Howard TP, Haswell JR, Wolf BK, Hawk WH, Ramos P, Oberlick EM, Tzvetkov EP, Vazquez F, Hahn WC, Park PJ, Roberts CWM. BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors. Nature Communications. 10: 1881. PMID 31015438 DOI: 10.1038/S41467-019-09891-7  0.341
2019 Price C, Gill S, Ho ZV, Davidson SM, Merkel E, McFarland JM, Leung L, Tang A, Kost-Alimova M, Tsherniak A, Jonas O, Vazquez F, Hahn WC. Genome-wide interrogation of human cancers identifies EGLN1 dependency in clear cell ovarian cancers. Cancer Research. PMID 30898838 DOI: 10.1158/0008-5472.Can-18-2674  0.54
2019 Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Hahn WC, et al. Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition. Elife. 8. PMID 30860482 DOI: 10.7554/Elife.44161  0.696
2019 Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, ... ... Hahn WC, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metabolism. PMID 30799286 DOI: 10.1016/J.Cmet.2019.01.020  0.727
2019 Hong AL, Guerriero JL, Doshi MB, Kynnap BD, Kim WJ, Schinzel AC, Modiste R, Schlauch AJ, Adam RM, Kwiatkowski DJ, Beroukhim R, Letai A, Rosenberg JE, Hahn WC. MCL1 and DEDD promote urothelial carcinoma progression. Molecular Cancer Research : McR. PMID 30777879 DOI: 10.1158/1541-7786.Mcr-18-0963  0.651
2019 Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, ... ... Hahn WC, et al. MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Research. PMID 30755442 DOI: 10.1158/0008-5472.Can-18-3066  0.735
2019 Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, ... ... Hahn WC, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine. PMID 30664779 DOI: 10.1038/S41591-018-0312-3  0.454
2019 Hong AL, Tseng Y, Wala JA, Kim W, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Hahn WC, et al. Author response: Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition Elife. DOI: 10.7554/Elife.44161.051  0.604
2019 De Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, Matthews G, Yiguo H, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Dempster J, Meyers RM, Bryan J, McFarland JM, Brueggenthies J, Tang H, ... ... Hahn WC, et al. Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma Blood. 134: 4407-4407. DOI: 10.1182/Blood-2019-130901  0.399
2019 Shirasaki R, Gandolfi S, De Matos Simoes R, Matthews GM, Buckley D, Raja J, Sievers QL, Dashevsky O, Poarch H, Tang H, Bariteau M, Sheffer M, Downey-Kopyscinski SL, Hengeveld P, Glassner B, ... ... Hahn WC, et al. Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins Blood. 134: 318-318. DOI: 10.1182/Blood-2019-130549  0.354
2019 Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham M, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, ... ... Hahn WC, et al. Abstract 2867: MDM2 and MDM4 are therapeutic vulnerabilities in malignant rhabdoid tumors Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2867  0.649
2019 Raghavan S, Winter PS, Navia A, Kalekar R, Galvez-Reyes J, Prakadan S, Wang J, Reilly E, Brais L, Cleary JM, Nowak J, Wolpin BM, Shalek AK, Aguirre AJ, Hahn WC. Abstract PR15: Assessment of tumor heterogeneity, clonal evolution, and the stromal microenvironment in metastatic pancreatic ductal adenocarcinoma and matched patient-derived organoids Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-Pr15  0.608
2019 Hahn WC. Abstract SY42-03: Systematic interrogation of cancer dependencies and synthetic lethal interactions Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Sy42-03  0.518
2019 Shirasaki R, de Matos Simoes R, Downey-Kopyscinski S, Matthews G, Hu Y, Sheffer M, Dhimolea E, Dashevsky O, Gandolfi S, Hengeveld P, Dempster J, Meyers R, Bryan J, Dharia N, McFarland J, ... ... Hahn W, et al. CRISPR studies identify genes preferentially essential for myeloma cells vs. other neoplasias: implications for future therapies selective against MM Clinical Lymphoma Myeloma and Leukemia. 19: e48-e49. DOI: 10.1016/J.Clml.2019.09.073  0.49
2018 Gannon HS, Zou T, Kiessling MK, Gao GF, Cai D, Choi PS, Ivan AP, Buchumenski I, Berger AC, Goldstein JT, Cherniack AD, Vazquez F, Tsherniak A, Levanon EY, Hahn WC, et al. Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nature Communications. 9: 5450. PMID 30575730 DOI: 10.1038/S41467-018-07824-4  0.625
2018 Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, ... ... Hahn WC, et al. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 175: 1972-1988.e16. PMID 30550791 DOI: 10.1016/J.Cell.2018.11.021  0.349
2018 McFarland JM, Ho ZV, Kugener G, Dempster JM, Montgomery PG, Bryan JG, Krill-Burger JM, Green TM, Vazquez F, Boehm JS, Golub TR, Hahn WC, Root DE, Tsherniak A. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nature Communications. 9: 4610. PMID 30389920 DOI: 10.1038/S41467-018-06916-5  0.41
2018 Choudhury AD, Werner L, Francini E, Wei XX, Ha G, Freeman SS, Rhoades J, Reed SC, Gydush G, Rotem D, Lo C, Taplin ME, Harshman LC, Zhang Z, O'Connor EP, ... ... Hahn WC, et al. Tumor fraction in cell-free DNA as a biomarker in prostate cancer. Jci Insight. 3. PMID 30385733 DOI: 10.1172/Jci.Insight.122109  0.531
2018 Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, ... ... Hahn WC, et al. Mutational processes shape the landscape of TP53 mutations in human cancer. Nature Genetics. PMID 30224644 DOI: 10.1038/S41588-018-0204-Y  0.683
2018 Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature Genetics. PMID 30127528 DOI: 10.1038/S41588-018-0191-Z  0.461
2018 Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer. Molecular Cancer Therapeutics. PMID 30097486 DOI: 10.1158/1535-7163.Mct-17-1090  0.692
2018 Sandoval GJ, Pulice JL, Pakula H, Schenone M, Takeda DY, Pop M, Boulay G, Williamson KE, McBride MJ, Pan J, St Pierre R, Hartman E, Garraway LA, Carr SA, Rivera MN, ... ... Hahn WC, et al. Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. Molecular Cell. PMID 30078722 DOI: 10.1016/J.Molcel.2018.06.040  0.347
2018 Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai C, Hagel K, Hong AL, Gjoerup O, Goel S, ... ... Hahn WC, et al. An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer. Elife. 7. PMID 30059005 DOI: 10.7554/Elife.37184  0.758
2018 Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, ... ... Hahn WC, et al. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29961768 DOI: 10.1038/S41436-018-0009-5  0.674
2018 Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, ... ... Hahn WC, et al. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nature Genetics. PMID 29955178 DOI: 10.1038/S41588-018-0155-3  0.593
2018 Takeda DY, Spisák S, Seo JH, Bell C, O'Connor E, Korthauer K, Ribli D, Csabai I, Solymosi N, Szállási Z, Stillman DR, Cejas P, Qiu X, Long HW, Tisza V, ... ... Hahn WC, et al. A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer. Cell. PMID 29909987 DOI: 10.1016/J.Cell.2018.05.037  0.378
2018 Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, ... ... Hahn WC, et al. Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine. Cancer Discovery. PMID 29903880 DOI: 10.1158/2159-8290.Cd-18-0275  0.592
2018 Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, ... ... Hahn WC, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nature Communications. 9: 2024. PMID 29789628 DOI: 10.1038/S41467-018-04356-9  0.34
2018 Pan J, Meyers RM, Michel BC, Mashtalir N, Sizemore AE, Wells JN, Cassel SH, Vazquez F, Weir BA, Hahn WC, Marsh JA, Tsherniak A, Kadoch C. Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens. Cell Systems. PMID 29778836 DOI: 10.1016/J.Cels.2018.04.011  0.324
2018 Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai C, Hagel K, Hong AL, Gjoerup O, Goel S, ... ... Hahn WC, et al. Author response: An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer Elife. DOI: 10.7554/Elife.37184.034  0.724
2018 Choudhury AD, Werner L, Ha G, Freeman S, Rhoades J, Reed S, Gydush G, Rotem D, Lo C, Taplin M, Harshman LC, Zhang Z, O'Connor EP, Boehm J, Getz G, ... ... Hahn WC, et al. Tumor fraction in circulating free DNA as a biomarker of disease dynamics in metastatic prostate cancer. Journal of Clinical Oncology. 36: 195-195. DOI: 10.1200/Jco.2018.36.6_Suppl.195  0.542
2018 Shirasaki R, Gandolfi S, De Matos Simoes R, Matthews G, Buckley D, Dashevsky O, Downey-Kopyscinski SL, Tang H, Sheffer M, Dhimolea E, Glassner B, Bariteau M, Sorrell J, Bruggenthies JB, Sievers Q, ... ... Hahn WC, et al. CRISPR-Based Functional Genomics Studies Reveal Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins: Implications for Novel Therapeutics across Diverse Neoplasias Blood. 132: 1367-1367. DOI: 10.1182/Blood-2018-99-116232  0.388
2018 De Matos Simoes R, Shirasaki R, Tang H, Sheffer M, Dashevsky O, Gandolfi S, Dhimolea E, Bariteau M, Licht JD, Glassner B, Groen RW, Levy J, Auclair D, Vazquez F, Tsherniak A, ... Hahn WC, et al. Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma Blood. 132: 189-189. DOI: 10.1182/Blood-2018-189  0.434
2018 Hahn WC. Abstract IA04: Opportunities for translational and discovery research: Next-Gen genomics Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Tcm17-Ia04  0.466
2018 Doberstein K, Karst A, Kroeger PT, Jones P, Hahn W, Drapkin R. Abstract PR01: Cyclin E: Targeting cell cycle dependencies in CCNE1-amplified tumors Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Ovca17-Pr01  0.459
2018 Hong AL, Tseng Y, Kynnap BD, Doshi MB, Wala J, Sandoval G, Church AJ, Mullen E, Kadoch C, Roberts CWM, Beroukhim R, Boehm JS, Hahn WC. Abstract B18: Modeling renal medullary carcinomas identifies druggable vulnerabilities in SMARCB1-deficient cancers Cancer Research. 78. DOI: 10.1158/1538-7445.Pedca17-B18  0.725
2018 Bullman S, Pedamallu CS, Sicinska E, Clancy T, Ogino S, Tabernero J, Fuchs C, Hahn WC, Nuciforo P, Meyerson M. Abstract 5129: Fusobacterium and co-occurring microbes in primary and metastatic colorectal cancer Cancer Research. 78: 5129-5129. DOI: 10.1158/1538-7445.Am2018-5129  0.614
2018 Dharia NV, Malone C, Iniguez AB, Guenther L, Chen L, Alexe G, Durbin AD, Zimmerman MW, Hong A, Bandopadhayay P, Filbin MG, Howard T, Paolella B, Fung I, Lee J, ... ... Hahn WC, et al. Abstract 2352: Defining a pediatric cancer dependency map Cancer Research. 78: 2352-2352. DOI: 10.1158/1538-7445.Am2018-2352  0.745
2018 Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Balboni-Iniguez A, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, et al. Abstract 2062: Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry Cancer Research. 78: 2062-2062. DOI: 10.1158/1538-7445.Am2018-2062  0.453
2018 Yeerna H, Kim W, Hahn WC, Mesirov J, Tamayo P. Abstract 1416: Pan-cancer mutual vulnerability and viability Cancer Research. 78: 1416-1416. DOI: 10.1158/1538-7445.Am2018-1416  0.473
2017 Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, ... ... Hahn WC, et al. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. The Journal of Clinical Investigation. PMID 29202477 DOI: 10.1172/Jci90793  0.456
2017 Horn H, Lawrence MS, Chouinard CR, Shrestha Y, Hu JX, Worstell E, Shea E, Ilic N, Kim E, Kamburov A, Kashani A, Hahn WC, Campbell JD, Boehm JS, Getz G, et al. NetSig: network-based discovery from cancer genomes. Nature Methods. PMID 29200198 DOI: 10.1038/Nmeth.4514  0.436
2017 Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, Chipashvili O, Hagan T, Walker M, Ramachandran A, Diosdado B, ... ... Hahn WC, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science (New York, N.Y.). PMID 29170280 DOI: 10.1126/Science.Aal5240  0.707
2017 Aguirre AJ, Hahn WC. Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers. Cold Spring Harbor Perspectives in Medicine. PMID 29101114 DOI: 10.1101/Cshperspect.A031518  0.655
2017 Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, ... ... Hahn WC, et al. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. Jama Oncology. PMID 29098284 DOI: 10.1001/Jamaoncol.2017.3420  0.592
2017 Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, ... ... Hahn WC, et al. Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6. PMID 29087937 DOI: 10.7554/Elife.33173  0.787
2017 Meyers RM, Bryan JG, McFarland JM, Weir BA, Sizemore AE, Xu H, Dharia NV, Montgomery PG, Cowley GS, Pantel S, Goodale A, Ali LD, Jiang G, Lubonja R, Harrington WF, ... ... Hahn WC, et al. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics. PMID 29083409 DOI: 10.1038/Ng.3984  0.448
2017 Gönen M, Weir BA, Cowley GS, Vazquez F, Guan Y, Jaiswal A, Karasuyama M, Uzunangelov V, Wang T, Tsherniak A, Howell S, Marbach D, Hoff B, Norman TC, Airola A, ... ... Hahn WC, et al. A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines. Cell Systems. PMID 28988802 DOI: 10.1016/J.Cels.2017.09.004  0.386
2017 Zhang X, Choi PS, Francis JM, Gao GF, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniak A, Taylor AM, Zhou J, Wu Z, Berger AC, ... ... Hahn WC, et al. Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discovery. PMID 28963353 DOI: 10.1158/2159-8290.Cd-17-0532  0.635
2017 Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, ... ... Hahn WC, et al. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. Cell Systems. 5: 105-118.e9. PMID 28837809 DOI: 10.1016/J.Cels.2017.08.002  0.618
2017 Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, ... ... Hahn WC, et al. Defining a Cancer Dependency Map. Cell. 170: 564-576.e16. PMID 28753430 DOI: 10.1016/J.Cell.2017.06.010  0.49
2017 Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, ... ... Hahn WC, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/Nature23007  0.594
2017 Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, ... ... Hahn WC, et al. Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Cancer Research. PMID 28655788 DOI: 10.1158/0008-5472.Can-17-0216  0.442
2017 Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, ... ... Hahn WC, et al. Synergistic interactions with PI3K inhibition that induce apoptosis. Elife. 6. PMID 28561737 DOI: 10.7554/Elife.24523  0.458
2017 Rosenbluh J, Xu H, Harrington W, Gill S, Wang X, Vazquez F, Root DE, Tsherniak A, Hahn WC. Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression. Nature Communications. 8: 15403. PMID 28534478 DOI: 10.1038/Ncomms15403  0.395
2017 Sandoval GJ, Hahn WC. Going beyond genetics to discover cancer targets. Genome Biology. 18: 95. PMID 28532420 DOI: 10.1186/S13059-017-1238-7  0.422
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, ... ... Hahn WC, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/Pnas.1617922114  0.626
2017 Wang B, Krall EB, Aguirre AJ, Kim M, Widlund HR, Doshi MB, Sicinska E, Sulahian R, Goodale A, Cowley GS, Piccioni F, Doench JG, Root DE, Hahn WC. ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. Cell Reports. 18: 1543-1557. PMID 28178529 DOI: 10.1016/J.Celrep.2017.01.031  0.816
2017 Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, ... ... Hahn WC, et al. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 6. PMID 28177281 DOI: 10.7554/Elife.23268  0.481
2017 Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, ... ... Hahn WC, et al. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6. PMID 28145866 DOI: 10.7554/Elife.18970  0.611
2017 Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, et al. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro-Oncology. PMID 28082416 DOI: 10.1093/Neuonc/Now261  0.337
2017 Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, ... ... Hahn WC, et al. Author response: Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability Elife. DOI: 10.7554/Elife.23268.025  0.4
2017 Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, ... ... Hahn WC, et al. Author response: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer Elife. DOI: 10.7554/Elife.18970.029  0.571
2017 Huang FW, Rinne ML, Lundgren KT, Mullane SA, Moreno I, Reed S, Gydush G, Adalsteinsson V, Novak J, Hahn WC, Signoretti S, Choueiri TK, Garraway LA, Bellmunt J. Cell-free tumor DNA and TERT promoter mutations in bladder cancer. Journal of Clinical Oncology. 35: 353-353. DOI: 10.1200/Jco.2017.35.6_Suppl.353  0.394
2017 Meyers RM, Aguirre AJ, Weir BA, Vazquez F, Zhang C, Ben-David U, Cook A, Ha G, Harrington WF, Doshi M, Gill S, Xu H, Ali LD, Jiang G, Pantel S, ... ... Hahn WC, et al. Abstract B39: Genomic copy number alterations introduce a gene-independent viability bias in CRISPR-Cas9 knock-out screens of cancer cell lines Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-B39  0.71
2017 Hahn WC. Abstract IA08: Systematic interrogation of cancer dependencies Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-Ia08  0.505
2017 Hong AL, Tseng Y, Kynnap BD, Doshi MB, Sandoval G, Oh C, Sayeed A, Shubhroz G, Church AJ, Keskula P, Peng A, Clemons PA, Tsherniak A, Vazquez F, Rodriguez-Galindo C, ... ... Hahn WC, et al. Abstract B17: Identification of Druggable Targets through Functional Multi-Omics in Renal Medullary Carcinoma Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-B17  0.71
2017 Li J, Choi P, Chaffer C, Labella K, Kim JW, Doench J, Dai C, Giacomelli A, Ly SH, Hwang J, Hong A, Ilic N, Gjoerup O, Meyerson M, Brooks A, ... ... Hahn W, et al. Abstract A36: Genome-scale ORF screening to identify modulators of the epithelial-to-mesenchymal transition Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A36  0.787
2017 Kim JW, Hahn WC, Mesirov J, Tamayo P. Abstract A09: Decomposing Oncogenic Transcriptional Signatures to Generate Maps of RAS/MAPK Cellular States Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A09  0.457
2017 Tseng Y(, Hong A, Gill S, Keskula P, Raghavan S, Cheah J, Tsherniak A, Vazquez F, Alkhairy S, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, Garraway L, ... ... Hahn W, et al. Abstract A02: Expanding tumor chemical-genetic interaction map using next-generation cancer models Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A02  0.735
2017 Horn H, Lawrence MS, Chouinard CR, Shrestha Y, Hu JX, Worstell E, Shea E, Ilic N, Kim E, Kamburov A, Kashani A, Hahn WC, Campbell JD, Boehm JS, Getz G, et al. Abstract 5567: A scalable and integrated computational and experimental workflow to identify new driver genes in cancer genome data Cancer Research. 77: 5567-5567. DOI: 10.1158/1538-7445.Am2017-5567  0.483
2017 Pan J, Meyers RM, Michel BC, Sizemore AE, Vazquez F, Weir BA, Hahn WC, Tsherniak A, Kadoch C. Abstract 5559: Using cancer dependency data to discover tumor suppressive and oncogenic functional modules Cancer Research. 77: 5559-5559. DOI: 10.1158/1538-7445.Am2017-5559  0.432
2017 Li J, Choi P, Chaffer C, Labella K, Kim JW, Doench J, Dai C, Giacomelli A, Ly SH, Hwang J, Hong A, Ilic N, Gjoerup O, Meyerson M, Brooks A, ... ... Hahn W, et al. Abstract 5020: A genome-scale ORF screen reveals an alternative splicing program that regulates mesenchymal and stem-like cell states in breast cancer Cancer Research. 77: 5020-5020. DOI: 10.1158/1538-7445.Am2017-5020  0.786
2017 Gannon HS, Kiessling M, Vazquez F, Hahn W, Meyerson M. Abstract 4616: Exploring the role of interferon and innate immune regulators in outlier cancer cell line survival Cancer Research. 77: 4616-4616. DOI: 10.1158/1538-7445.Am2017-4616  0.603
2017 Kim E, Ly SH, Persky NS, Wang B, Yang X, Piccioni F, Labella K, Doshi M, Lintner RE, Zhu C, Steelman S, Root DE, Johannessen CM, Burgin AB, MacConaill LE, ... Hahn WC, et al. Abstract 394: Saturation mutagenesis of KRAS reveals the functional landscape of missense variants Cancer Research. 77: 394-394. DOI: 10.1158/1538-7445.Am2017-394  0.52
2017 Ly SH, Dai C, Hong AL, Ilic N, Krall EB, Hahn WC. Abstract 3515: LHX9 is a novel oncogene bypassing KRAS addiction Cancer Research. 77: 3515-3515. DOI: 10.1158/1538-7445.Am2017-3515  0.633
2017 Aguirre AJ, Carter S, Camarda N, Ghazani A, Nowak J, Silva AD, Brais L, Ragon D, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Shyn P, ... ... Hahn WC, et al. Abstract 3036: Real-time genomic characterization of metastatic pancreatic cancer to enable precision medicine Cancer Research. 77: 3036-3036. DOI: 10.1158/1538-7445.Am2017-3036  0.591
2017 Kim WJ, Hahn WC, Mesirov J, Tamayo P. Abstract 3035: Decomposing oncogenic transcriptional signatures to generate maps of divergent cellular states Cancer Research. 77: 3035-3035. DOI: 10.1158/1538-7445.Am2017-3035  0.471
2017 Han GC, Hwang J, Mullane SA, Cibulskis C, Zhang Z, McKay RR, Carter SL, Hahn WC, Taplin M, Allen EMV. Abstract 2905: Clinical and genomic resistance to second generation androgen blockade in paired biopsies of metastatic castration-resistant prostate cancer Cancer Research. 77: 2905-2905. DOI: 10.1158/1538-7445.Am2017-2905  0.394
2017 Tseng Y, Hong A, Keskula P, Gill S, Cheah J, Kryukov G, Tsherniak A, Vazquez F, Cowley G, Alkhairy S, Oh C, Peng A, Deasy R, Sayeed A, Ronning P, ... ... Hahn W, et al. Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models Cancer Research. 77: 1953-1953. DOI: 10.1158/1538-7445.Am2017-1953  0.688
2017 Doberstein K, Karst A, Jones P, Ligon A, Hirsch M, Etemadmoghadam D, Hahn W, Bowtell D, Drapkin R. Abstract 1425: Targeting cell cycle dependencies inCCNE1amplified tumors Cancer Research. 77: 1425-1425. DOI: 10.1158/1538-7445.Am2017-1425  0.36
2017 Henderson J, Cho H, Davare M, Tsherniak A, Cowley G, Weir B, Hahn WC, Cho Y. PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF MYC-AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET Neuro-Oncology. 19: vi197-vi197. DOI: 10.1093/Neuonc/Nox168.799  0.332
2017 Paolella B, Gibson W, Urbanski L, Alberta J, Zack T, Bandopadhayay P, Nichols C, Brown M, Lamothe R, Yu Y, Choi P, Obeng E, Wei G, Wong B, Tsherniak A, ... ... Hahn W, et al. BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS Neuro-Oncology. 19: iv4-iv4. DOI: 10.1093/Neuonc/Nox083.012  0.452
2016 Choudhury AD, Schinzel AC, Cotter MB, Lis RT, Labella K, Lock YJ, Izzo F, Guney I, Bowden M, Li YY, Patel J, Hartman E, Carr SA, Schenone M, Jaffe JD, ... ... Hahn WC, et al. Castration resistance in prostate cancer is mediated by the kinase NEK6. Cancer Research. PMID 27899381 DOI: 10.1158/0008-5472.Can-16-0455  0.43
2016 Sholl LM, Do K, Shivdasani P, Cerami E, Dubuc AM, Kuo FC, Garcia EP, Jia Y, Davineni P, Abo RP, Pugh TJ, van Hummelen P, Thorner AR, Ducar M, Berger AH, ... ... Hahn WC, et al. Institutional implementation of clinical tumor profiling on an unselected cancer population. Jci Insight. 1: e87062. PMID 27882345 DOI: 10.1172/Jci.Insight.87062  0.602
2016 Howard TP, Vazquez F, Tsherniak A, Hong AL, Rinne M, Aguirre AJ, Boehm JS, Hahn WC. Functional Genomic Characterization of Cancer Genomes. Cold Spring Harbor Symposia On Quantitative Biology. PMID 27815544 DOI: 10.1101/Sqb.2016.81.031070  0.796
2016 Li H, Mar BG, Zhang H, Puram RV, Vazquez F, Weir BA, Hahn WC, Ebert B, Pellman D. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood. PMID 27756750 DOI: 10.1182/Blood-2016-05-714493  0.431
2016 Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, ... Hahn WC, et al. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Cell Systems. 3: 302-316.e4. PMID 27684187 DOI: 10.1016/J.Cels.2016.09.001  0.406
2016 Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro-Oncology. PMID 27402815 DOI: 10.1093/Neuonc/Now139  0.302
2016 Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, ... ... Hahn WC, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.Mcr-16-0090  0.356
2016 Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, ... ... Hahn WC, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nature Communications. 7: 11987. PMID 27329820 DOI: 10.1038/Ncomms11987  0.731
2016 Aguirre AJ, Meyers RM, Weir BA, Vazquez F, Zhang CZ, Ben-David U, Cook A, Ha G, Harrington WF, Doshi MB, Kost-Alimova M, Gill S, Xu H, Ali LD, Jiang G, ... ... Hahn WC, et al. Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting. Cancer Discovery. PMID 27260156 DOI: 10.1158/2159-8290.Cd-16-0154  0.685
2016 Kim E, Ilic N, Shrestha Y, Zou L, Kamburov A, Zhu C, Yang X, Lubonja R, Tran N, Nguyen C, Lawrence MS, Piccioni F, Bagul M, Doench JG, Chouinard CR, ... ... Hahn WC, et al. Systematic functional interrogation of rare cancer variants identifies oncogenic alleles. Cancer Discovery. PMID 27147599 DOI: 10.1158/2159-8290.Cd-16-0160  0.485
2016 Kim JW, Botvinnik OB, Abudayyeh O, Birger C, Rosenbluh J, Shrestha Y, Abazeed ME, Hammerman PS, DiCara D, Konieczkowski DJ, Johannessen CM, Liberzon A, Alizad-Rahvar AR, Alexe G, Aguirre A, ... ... Hahn WC, et al. Characterizing genomic alterations in cancer by complementary functional associations. Nature Biotechnology. PMID 27088724 DOI: 10.1038/Nbt.3527  0.642
2016 Kryukov GV, Wilson FH, Ruth JR, Paulk J, Tsherniak A, Marlow SE, Vazquez F, Weir BA, Fitzgerald ME, Tanaka M, Bielski CM, Scott JM, Dennis C, Cowley GS, Boehm JS, ... ... Hahn WC, et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science (New York, N.Y.). PMID 26912360 DOI: 10.1126/Science.Aad5214  0.533
2016 Hong AL, Tseng Y, Cowley G, Jonas O, Cheah J, Doshi M, Kynnap B, Oy C, Keskula P, Kryukov G, Cima M, Langer R, Schreiber S, Root D, Boehm J, ... Hahn W, et al. Abstract PR04: Integration of CRISPR-Cas9, RNAi and pharmacologic screens identify actionable targets in a rare cancer Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-Pr04  0.699
2016 Tseng Y, Keskula P, Hong AL, Gill S, Cheah JH, Kryukov GV, Tsherniak A, Vazquez F, Cowley G, Oh C, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, ... ... Hahn WC, et al. Abstract B26: Accelerating prediction of tumor vulnerabilities using next-generation cancer models Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B26  0.732
2016 Raghavan S, Gill S, Aguirre AJ, Tseng YM, Peng A, Keskula P, Wu X, Oh C, Cheah J, Kryukov G, Sicinska E, Wolpin BM, Kulke MH, Fuchs CS, Clemons P, ... ... Hahn WC, et al. Abstract B13: Human pancreatic cancer organoids for functional dependency profiling Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B13  0.639
2016 Doberstein K, Karst A, Etemadmoghadam D, Jones P, Dunn G, Hahn W, Bowtell D, Drapkin R. Abstract PR05: Identifying potential targets in Cyclin E-amplified tumors. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-Pr05  0.501
2016 Hong AL, Cowley GS, Tseng Y, Cheah JH, Jonas O, Doshi MB, Kynnap BD, Oh C, Meyer S, Clemons P, Burger M, Vazquez F, Weir B, Kryukov GV, Church A, ... ... Hahn WC, et al. Abstract B38: Developing a functional genomics platform to interrogate rare pediatric cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-B38  0.731
2016 Aguirre AJ, Shao W, Xu H, Weir B, Vazquez F, Meyers R, Zhang C, Doshi M, Cowley GS, Ewachiw T, Rasheed Z, Golub TR, Stegmaier K, Roberts CW, Garraway LA, ... ... Hahn WC, et al. Abstract PR05: Genome-scale CRISPR-Cas9 screening to identify essential genes and pathways in pancreatic cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-Pr05  0.679
2016 Sandoval GJ, Pulice JL, Takeda DY, Schenone MA, Pop M, Boulay G, Rivera MN, Ronco L, Hahn WC, Kadoch C. Abstract 882: TMPRSS2-ERG drives global mistargeting of mammalian SWI/SNF (BAF) complexes in prostate cancer Cancer Research. 76: 882-882. DOI: 10.1158/1538-7445.Am2016-882  0.422
2016 Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Ebert BL, ... ... Hahn WC, et al. Abstract 4369: Genome-wide copy number dependency analysis identifies partial copy loss of SF3B1 as a novel cancer vulnerability Cancer Research. 76: 4369-4369. DOI: 10.1158/1538-7445.Am2016-4369  0.424
2016 Thorner AR, Ziaugra L, Ducar MD, Lin L, Laing A, Coleman HA, McShane SR, Clapp A, Paquette RR, Wollison BM, Hoeftberger J, Patel NA, Hunter SS, Manam MD, MacConaill LE, ... Hahn WC, et al. Abstract 3644: Optimization of library construction for massively parallel sequencing using low-input, FFPE-derived DNA without additional PCR amplification Cancer Research. 76: 3644-3644. DOI: 10.1158/1538-7445.Am2016-3644  0.323
2016 Hanaford AR, Archer TC, Price A, Kahlert U, Maciaczyk J, Guido N, Kim W, Ehrenberger T, Clemons P, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart M, Rees M, Shamji A, ... Hahn W, et al. Abstract 2476: DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with advanced in silico analysis to identify novel therapeutic targets Cancer Research. 76: 2476-2476. DOI: 10.1158/1538-7445.Am2016-2476  0.343
2015 Hahn WC. New Functions for Telomerase. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 35: 467-71. PMID 26680976 DOI: 10.4143/Crt.2003.35.6.467  0.372
2015 Huang FW, Bielski CM, Rinne ML, Hahn WC, Sellers WR, Stegmeier F, Garraway LA, Kryukov GV. TERT promoter mutations and monoallelic activation of TERT in cancer. Oncogenesis. 4: e176. PMID 26657580 DOI: 10.1038/oncsis.2015.39  0.341
2015 Gannon HS, Kaplan N, Tsherniak A, Vazquez F, Weir BA, Hahn WC, Meyerson M. Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-targeted Therapy. Molecular Cancer Research : McR. PMID 26582713 DOI: 10.1158/1541-7786.Mcr-15-0321  0.602
2015 Luo LY, Hahn WC. Oncogenic Signaling Adaptor Proteins. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 42: 521-9. PMID 26554907 DOI: 10.1016/J.Jgg.2015.09.001  0.447
2015 Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine. PMID 26552009 DOI: 10.1038/Nm.3968  0.467
2015 Hettmer S, Schinzel AC, Tchessalova D, Schneider M, Parker CL, Bronson R, Richards NG, Hahn W, Wagers AJ. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. Elife. 4. PMID 26499495 DOI: 10.1186/2194-7791-2-S1-A3  0.428
2015 Pomerantz MM, Li F, Takeda DY, Lenci R, Chonkar A, Chabot M, Cejas P, Vazquez F, Cook J, Shivdasani RA, Bowden M, Lis R, Hahn WC, Kantoff PW, Brown M, et al. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nature Genetics. PMID 26457646 DOI: 10.1038/Ng.3419  0.316
2015 Baselga J, Bhardwaj N, Cantley LC, DeMatteo R, DuBois RN, Foti M, Gapstur SM, Hahn WC, Helman LJ, Jensen RA, Paskett ED, Lawrence TS, Lutzker SG, Szabo E. AACR Cancer Progress Report 2015. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: S1-S128. PMID 26429991 DOI: 10.1158/1078-0432.Ccr-15-1846  0.398
2015 Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, ... ... Hahn WC, et al. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discovery. PMID 26410082 DOI: 10.1158/2159-8290.Cd-15-0369  0.699
2015 Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, ... ... Hahn WC, et al. Rapid Intraoperative Molecular Characterization of Glioma. Jama Oncology. PMID 26181761 DOI: 10.1001/Jamaoncol.2015.0917  0.604
2015 Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nature Medicine. 21: 335-43. PMID 25822366 DOI: 10.1038/Nm.3832  0.349
2015 Wilson FH, Johannessen CM, Piccioni F, Tamayo P, Kim JW, Van Allen EM, Corsello SM, Capelletti M, Calles A, Butaney M, Sharifnia T, Gabriel SB, Mesirov JP, Hahn WC, Engelman JA, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 27: 397-408. PMID 25759024 DOI: 10.1016/J.Ccell.2015.02.005  0.505
2015 Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, Curtis J, Piao H, Wong LC, Kung AL, Beroukhim R, Bradner JE, Drapkin R, Hahn WC, Liu JF, et al. An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 112: 232-7. PMID 25535366 DOI: 10.1073/Pnas.1422165112  0.477
2015 Abo RP, Ducar M, Garcia EP, Thorner AR, Rojas-Rudilla V, Lin L, Sholl LM, Hahn WC, Meyerson M, Lindeman NI, Van Hummelen P, MacConaill LE. BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers. Nucleic Acids Research. 43: e19. PMID 25428359 DOI: 10.1093/Nar/Gku1211  0.536
2015 Luo LY, Kim E, Cheung HW, Weir BA, Dunn GP, Shen RR, Hahn WC. The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. Molecular Cancer Research : McR. 13: 502-9. PMID 25368431 DOI: 10.1158/1541-7786.Mcr-14-0407  0.5
2015 Moody SE, Schinzel AC, Singh S, Izzo F, Strickland MR, Luo L, Thomas SR, Boehm JS, Kim SY, Wang ZC, Hahn WC. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene. 34: 2061-71. PMID 24909179 DOI: 10.1038/Onc.2014.153  0.4
2015 Shen RR, Zhou AY, Kim E, O'Connell JT, Hagerstrand D, Beroukhim R, Hahn WC. TRAF2 is an NF-κB-activating oncogene in epithelial cancers. Oncogene. 34: 209-16. PMID 24362534 DOI: 10.1038/Onc.2013.543  0.485
2015 Hahn WC. Abstract KP02: Functional genomics, cancer biology and targets Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Ovcasymp14-Kp02  0.506
2015 Berger AH, Kim E, Brooks A, Ilic N, Shrestha Y, Tseng Y, Wu X, Zou L, Kamburov A, Yang X, Zhu C, Keskula P, Seepo S, Hong A, Kantoff P, ... ... Hahn WC, et al. Abstract PR07: Towards precision functional genomics via next-generation functional mapping of cancer variants Cancer Research. 75: 957-957. DOI: 10.1158/1538-7445.Transcagen-Pr07  0.78
2015 Sevenich L, Bowman R, Mason S, Quail D, Rapaport F, Elie B, Brogi E, Brastianos P, Hahn W, Holsinger L, Massagué J, Leslie C, Joyce JA. Abstract IA18: A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-Ia18  0.618
2015 Berger A, Kim E, Brooks A, Shrestha Y, Tseng Y, Wu X, Ilic N, Zou L, Kamburov A, Yang X, Zhu C, Keskula P, Seepo S, Hong A, Doench J, ... ... Hahn W, et al. Abstract 957: Towards precision functional genomics via next-generation functional mapping of cancer variants Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2015-957  0.719
2015 Abo RP, Lin L, Hunter SS, Dolcen DN, Paquette RR, Laing A, Waal Ld, Thorner AR, Ducar MD, Ziaugra L, Hahn WC, Meyerson ML, MacConaill LE, Hummelen PV. Abstract 4867: Comparative analysis of RNA sequencing methods for characterization of cancer transcriptomics Cancer Research. 75: 4867-4867. DOI: 10.1158/1538-7445.Am2015-4867  0.377
2015 Brastianos PK, Carter SL, Santagata S, Taylor-Weiner A, Jones RT, Allen EV, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Cahill D, Curry WT, Dunn IF, Paek SH, Hummelen PV, ... ... Hahn WC, et al. Abstract 4727: Genomic characterization of brain metastases reveals divergent evolution and metastasis specific mutations Brain. 75: 4727-4727. DOI: 10.1158/1538-7445.Am2015-4727  0.7
2015 Huang X, Jayabalan D, Liberto MD, Mark TM, Chen Z, Rossi A, Schinzel AC, Hahn WC, Hussein MA, Niesvizky R, Chen-Kiang S. Abstract 4031: CDK4/6 inhibition amplifies IMiD killing of myeloma cells by accelerating CRL4CRBN-dependent degradation of IKZF1 and IKZF3 in opposition to MEIS2 Cancer Research. 75: 4031-4031. DOI: 10.1158/1538-7445.Am2015-4031  0.313
2015 Hettmer S, Schinzel AC, Tchessalova D, Richards NG, Hahn WC, Wagers AJ. Abstract 1187: Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma Cancer Research. 75: 1187-1187. DOI: 10.1158/1538-7445.Am2015-1187  0.465
2015 Lin L, Abo R, Dolcen D, Paquette R, Laing A, Waal Ld, Thorner A, Ducar M, Ziaugra L, Wollison B, Breneiser M, Hahn W, Meyerson M, Hummelen PV, MacConaill L. Abstract 1115: Targeted RNA sequencing improves transcript analysis in cancer samples Cancer Research. 75: 1115-1115. DOI: 10.1158/1538-7445.Am2015-1115  0.538
2015 Zwang Y, Chen C, Hahn WC. Abstract C73: A drug-modifier whole-genome shRNA screen identifies novel synthetic lethal interactions with PI3K inhibition in breast cancer Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C73  0.496
2015 Brastianos P, Carter S, Santagata S, Cahill D, Taylor-Weiner A, Jones R, Ligon K, Tabernero J, Seoane J, Martinez Saez E, Johnson B, Choueiri T, Stemmer-Rachamimov A, Lin N, Beroukhim R, ... ... Hahn W, et al. 2905 Genomic characterization of brain metastases and paired primary tumors reveals branched evolution and potential therapeutic targets European Journal of Cancer. 51: S586. DOI: 10.1016/S0959-8049(16)31622-7  0.568
2014 Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, ... ... Hahn WC, et al. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Scientific Data. 1: 140035. PMID 25984343 DOI: 10.1038/Sdata.2014.35  0.429
2014 Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, ... ... Hahn WC, et al. Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Scientific Data. 1: 140044. PMID 25982629 DOI: 10.1038/Sdata.2014.44  0.369
2014 Barbie TU, Alexe G, Aref AR, Li S, Zhu Z, Zhang X, Imamura Y, Thai TC, Huang Y, Bowden M, Herndon J, Cohoon TJ, Fleming T, Tamayo P, Mesirov JP, ... ... Hahn WC, et al. Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth. The Journal of Clinical Investigation. 124: 5411-23. PMID 25365225 DOI: 10.1172/Jci75661  0.419
2014 Giannakis M, Hodis E, Jasmine Mu X, Yamauchi M, Rosenbluh J, Cibulskis K, Saksena G, Lawrence MS, Qian ZR, Nishihara R, Van Allen EM, Hahn WC, Gabriel SB, Lander ES, Getz G, et al. RNF43 is frequently mutated in colorectal and endometrial cancers. Nature Genetics. 46: 1264-6. PMID 25344691 DOI: 10.1038/Ng.3127  0.39
2014 MacConaill LE, Garcia E, Shivdasani P, Ducar M, Adusumilli R, Breneiser M, Byrne M, Chung L, Conneely J, Crosby L, Garraway LA, Gong X, Hahn WC, Hatton C, Kantoff PW, et al. Prospective enterprise-level molecular genotyping of a cohort of cancer patients. The Journal of Molecular Diagnostics : Jmd. 16: 660-72. PMID 25157968 DOI: 10.1016/J.Jmoldx.2014.06.004  0.454
2014 Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 88: 12055-64. PMID 25122798 DOI: 10.1128/Jvi.01399-14  0.344
2014 Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massagué J, Leslie CS, Joyce JA. Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nature Cell Biology. 16: 876-88. PMID 25086747 DOI: 10.1038/Ncb3011  0.57
2014 Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158: 171-84. PMID 24954536 DOI: 10.1016/J.Cell.2014.06.004  0.818
2014 Kim YM, Lee SW, Chun SM, Kim DY, Kim JH, Kim KR, Kim YT, Nam JH, van Hummelen P, MacConaill LE, Hahn WC, Jang SJ. Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples. Plos One. 9: e99451. PMID 24936796 DOI: 10.1371/Journal.Pone.0099451  0.412
2014 Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, Fisher DE, Mesirov JP, Hahn WC, Flaherty KT, Wargo JA, et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discovery. 4: 816-27. PMID 24771846 DOI: 10.1158/2159-8290.Cd-13-0424  0.36
2014 Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, et al. Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood. 124: 13-23. PMID 24764564 DOI: 10.1182/Blood-2014-02-558114  0.39
2014 Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, Francis JM, Zhang CZ, Shalek AK, Satija R, Trombetta JJ, Lu D, Tallapragada N, Tahirova N, Kim S, ... ... Hahn WC, et al. Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nature Biotechnology. 32: 479-84. PMID 24752078 DOI: 10.1038/Nbt.2892  0.593
2014 Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW. ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nature Medicine. 20: 251-4. PMID 24562383 DOI: 10.1038/Nm.3480  0.674
2014 Yao X, Choudhury AD, Yamanaka YJ, Adalsteinsson VA, Gierahn TM, Williamson CA, Lamb CR, Taplin ME, Nakabayashi M, Chabot MS, Li T, Lee GS, Boehm JS, Kantoff PW, Hahn WC, et al. Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 388-98. PMID 24522233 DOI: 10.1039/C3Ib40264A  0.415
2014 Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, ... ... Hahn WC, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discovery. 4: 452-65. PMID 24444711 DOI: 10.1158/2159-8290.Cd-13-0646  0.368
2014 Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, ... ... Hahn WC, et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Reports. 6: 313-24. PMID 24440720 DOI: 10.1016/J.Celrep.2013.12.032  0.398
2014 Wilson BG, Helming KC, Wang X, Kim Y, Vazquez F, Jagani Z, Hahn WC, Roberts CW. Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Molecular and Cellular Biology. 34: 1136-44. PMID 24421395 DOI: 10.1128/Mcb.01372-13  0.452
2014 Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, ... ... Hahn WC, et al. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nature Genetics. 46: 161-5. PMID 24413733 DOI: 10.1038/Ng.2868  0.662
2014 Dunn GP, Cheung HW, Agarwalla PK, Thomas S, Zektser Y, Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L, Getz G, Liu JF, Hirsch M, Vazquez F, Root DE, ... ... Hahn WC, et al. In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proceedings of the National Academy of Sciences of the United States of America. 111: 1102-7. PMID 24385586 DOI: 10.1073/Pnas.1311909111  0.512
2014 Rosenbluh J, Wang X, Hahn WC. Genomic insights into WNT/β-catenin signaling. Trends in Pharmacological Sciences. 35: 103-9. PMID 24365576 DOI: 10.1016/J.Tips.2013.11.007  0.404
2014 Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA. An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 33: 5637-48. PMID 24317510 DOI: 10.1038/Onc.2013.517  0.446
2014 Huang X, Di Liberto M, Chiron D, Niesvizky R, Schinzel AC, Hahn WC, Chen-Kiang S. Sensitizing shRNA Screen for Molecular Targets in CDK4/CDK6-Based Combination Therapy in Multiple Myeloma Blood. 124: 3440-3440. DOI: 10.1182/Blood.V124.21.3440.3440  0.446
2014 Hahn WC. Abstract IA08: Systematic functional genomics and KRAS Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-Ia08  0.506
2014 Hahn WC. Abstract IA14: Functional genomics and cancer vulnerabilities Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-Ia14  0.502
2014 Hahn WC. Abstract SY36-01: Functional genomics and cancer dependencies Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy36-01  0.504
2014 Brastianos PK, Carter SL, Santagata S, Taylor-Weiner A, Jones RT, Horowitz PM, Ligon KL, Seaone J, Martinez-Saez E, Tabernero J, Cahill DP, Paek S, Dunn IF, Johnson BE, Choueiri TK, ... ... Hahn WC, et al. Abstract NG03: Genomic characterization of 101 brain metastases and paired primary tumors reveals patterns of clonal evolution and selection of driver mutations Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Ng03  0.687
2014 Helming K, Wang X, Wilson B, Vazquez F, Haswell J, Manchester H, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway L, Hahn W, Roberts C. Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-126  0.669
2014 Adalsteinsson VA, Lohr JG, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, Francis J, Zhang C, Shalek AK, Satija R, Trombetta JT, Lu D, Tallapragada N, Tahirova NT, Kim S, ... ... Hahn WC, et al. Abstract 993: Whole exome sequencing of CTCs as a window into metastatic cancer Cancer Research. 74: 993-993. DOI: 10.1158/1538-7445.Am2014-993  0.602
2014 Taylor-Weiner AN, Brastianos PK, Manley PE, Jones RT, Dias-Sangata D, Thorner A, Rodriguez F, Bernardo L, Schubert L, Stewart C, Keiran M, Hahn WC, Resnick A, Louis D, Sangata S, et al. Abstract 935: Exome sequencing reveals BRAF mutations in papillary craniopharyngiomas Cancer Research. 74: 935-935. DOI: 10.1158/1538-7445.Am2014-935  0.591
2014 Abo RP, Garcia EP, Ducar M, Adusumilli R, Breneiser M, Rojas-Rudilla V, Sholl LM, Lindeman NI, Meyerson ML, Hahn WC, Hummelen PV, MacConaill LE. Abstract 5321: BreaKmer: Detection of structural rearrangements in targeted next-generation sequencing data using kmers Cancer Research. 74: 5321-5321. DOI: 10.1158/1538-7445.Am2014-5321  0.386
2014 Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend E, Bodegom Dv, Day TA, Wu S, Liu H, Yoda A, Alexe G, Schinzel A, Sullivan TJ, Malinge S, ... ... Hahn WC, et al. Abstract 433: Triplication of HMGN1 promotes B cell acute lymphoblastic leukemia (B-ALL) through suppression of H3K27me3 Cancer Research. 74: 433-433. DOI: 10.1158/1538-7445.Am2014-433  0.366
2014 Carter SL, Brastianos PK, McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Cibulskis K, Jacks T, Hahn W, Getz G. Abstract 3992: Modes of metastasis evolution in human and murine cancer revealed by whole exome sequencing Cancer Research. 74: 3992-3992. DOI: 10.1158/1538-7445.Am2014-3992  0.717
2014 Thorner AR, Sunkavalli A, Lin L, Jones RT, Schubert L, Ducar MD, Adusumilli R, Dolcen DN, Ziaugra L, Lepine J, MacConaill LE, Hahn WC, Meyerson M, Hummelen PV. Abstract 3583: Reducing GC-bias and improving coverage distribution in Illumina sequencing using the Kapa Biosystems library construction method Cancer Research. 74: 3583-3583. DOI: 10.1158/1538-7445.Am2014-3583  0.494
2014 Hong AL, Riester M, Schinzel AC, Schlauch A, Adam RM, Kwiatkowski DJ, Rosenberg JE, Hahn WC. Abstract 3433: ARHGAP30 and DEDD as potential genomic drivers of invasive urothelial carcinomas Cancer Research. 74: 3433-3433. DOI: 10.1158/1538-7445.Am2014-3433  0.709
2014 Brastianos P, Carter S, Santagata S, Taylor-Weiner A, Jones R, Van Allen E, Horowitz P, Ligon K, Cahill D, Dunn I, Van Hummelen P, Lin N, Curry W, Stemmer-Rachamimov A, Beroukhim R, ... ... Hahn W, et al. BM-07 * GENOMIC CHARACTERIZATION OF BRAIN METASTASES REVEALS BRANCHED EVOLUTION AND METASTASIS-SPECIFIC MUTATIONS Neuro-Oncology. 16: v33-v33. DOI: 10.1093/Neuonc/Nou240.7  0.68
2014 Hahn WC, Weinberg RA. Cancer: A Genetic Disorder The Molecular Basis of Cancer: Fourth Edition. 3-18.e1. DOI: 10.1016/B978-1-4557-4066-6.00001-9  0.451
2013 Etemadmoghadam D, Weir BA, Au-Yeung G, Alsop K, Mitchell G, George J, Davis S, D'Andrea AD, Simpson K, Hahn WC, Bowtell DD. Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proceedings of the National Academy of Sciences of the United States of America. 110: 19489-94. PMID 24218601 DOI: 10.1073/Pnas.1314302110  0.481
2013 Hanna MC, Go C, Roden C, Jones RT, Pochanard P, Javed AY, Javed A, Mondal C, Palescandolo E, Van Hummelen P, Hatton C, Bass AJ, Chun SM, Na DC, Kim TI, ... ... Hahn WC, et al. Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. Plos One. 8: e74950. PMID 24066160 DOI: 10.1371/Journal.Pone.0074950  0.556
2013 Wright AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E, Van Hummelen P, MacConaill LE, Shoni M, Wagle N, Jones RT, Quick CM, Laury A, Katz IT, Hahn WC, Matulonis UA, et al. Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer. 119: 3776-83. PMID 24037752 DOI: 10.1002/Cncr.28288  0.437
2013 Etemadmoghadam D, Au-Yeung G, Wall M, Mitchell C, Kansara M, Loehrer E, Batzios C, George J, Ftouni S, Weir BA, Carter S, Gresshoff I, Mileshkin L, Rischin D, Hahn WC, et al. Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5960-71. PMID 24004674 DOI: 10.1158/1078-0432.Ccr-13-1337  0.495
2013 Hagerstrand D, Tong A, Schumacher SE, Ilic N, Shen RR, Cheung HW, Vazquez F, Shrestha Y, Kim SY, Giacomelli AO, Rosenbluh J, Schinzel AC, Spardy NA, Barbie DA, Mermel CH, ... ... Hahn WC, et al. Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. Cancer Discovery. 3: 1044-57. PMID 23764425 DOI: 10.1158/2159-8290.Cd-12-0592  0.419
2013 Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 153: 1327-39. PMID 23746844 DOI: 10.1016/J.Cell.2013.04.048  0.317
2013 Serra V, Eichhorn PJ, García-García C, Ibrahim YH, Prudkin L, Sánchez G, Rodríguez O, Antón P, Parra JL, Marlow S, Scaltriti M, Pérez-Garcia J, Prat A, Arribas J, Hahn WC, et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. The Journal of Clinical Investigation. 123: 2551-63. PMID 23635776 DOI: 10.1172/Jci66343  0.44
2013 Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, ... ... Hahn WC, et al. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proceedings of the National Academy of Sciences of the United States of America. 110: 8188-93. PMID 23633565 DOI: 10.1073/Pnas.1300252110  0.662
2013 Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC. IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Reports. 3: 724-33. PMID 23453969 DOI: 10.1016/J.Celrep.2013.01.031  0.366
2013 Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, ... Hahn WC, et al. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nature Genetics. 45: 285-9. PMID 23334667 DOI: 10.1038/Ng.2526  0.684
2013 Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, et al. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes & Development. 27: 197-210. PMID 23322301 DOI: 10.1101/Gad.203208.112  0.627
2013 Shao DD, Tsherniak A, Gopal S, Weir BA, Tamayo P, Stransky N, Schumacher SE, Zack TI, Beroukhim R, Garraway LA, Margolin AA, Root DE, Hahn WC, Mesirov JP. ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens. Genome Research. 23: 665-78. PMID 23269662 DOI: 10.1101/Gr.143586.112  0.41
2013 Rollins BJ, MacConaill LE, Wagle N, Garcia E, Kuo FC, Longtine JA, Garber JE, Janeway KA, Fuchs CS, Bertagnolli MM, Soiffer R, Matulonis U, Lin NU, Hahn WC, Garraway LA, et al. PROFILE: Broadly based genomic testing for all patients at a major cancer center. Journal of Clinical Oncology. 31: 1531-1531. DOI: 10.1200/Jco.2013.31.15_Suppl.1531  0.385
2013 David Chen C, Sinha AU, Qi J, Deshpande AJ, Zhu N, Koche R, Eng R, Chang J, Hahn WC, Bradner JE, Armstrong SA. Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL-Rearranged Leukemia Blood. 122: 598-598. DOI: 10.1182/Blood.V122.21.598.598  0.41
2013 Hahn WC. Abstract IA29: Functional genomics, experimental models and cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia29  0.514
2013 Hummelen PV, Ducar M, Jones RT, Raza A, Sunkavalli A, Hanna M, Mills A, Adusumilli R, Kumar P, Schubert L, Breneiser M, Cooley AC, Garcia E, Scholl LM, Lindeman NI, ... ... Hahn WC, et al. Abstract 819: Targeted sequencing to detect somatic mutations, translocations and copy-number variation in human tumors simultaneously. Cancer Research. 73: 819-819. DOI: 10.1158/1538-7445.Am2013-819  0.48
2013 Brastianos P, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon K, Hummelen PV, Ducar M, Raza A, Sunkavalli A, MacConaill L, Stemmer-Rachamimov A, Louis DN, Hahn WC, et al. Abstract 803: Genomic sequencing of meningiomas reveals oncogenic SMO and AKT1 mutations. Cancer Research. 73: 803-803. DOI: 10.1158/1538-7445.Am2013-803  0.7
2013 Serra V, Eichhorn PJ, García-García C, Ibrahim Y, Prudkin L, Rodríguez O, Marlow S, Prat A, Hahn WC, Baselga J. Abstract 4452: p90RSK mediates resistance to PI3K-pathway inhibitors in breast cancer. Cancer Research. 73: 4452-4452. DOI: 10.1158/1538-7445.Am2013-4452  0.444
2013 Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, Rajagopal J, et al. Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Cancer Research. 73: 3127-3127. DOI: 10.1158/1538-7445.Am2013-3127  0.655
2013 Yao X, Choudhury AD, Yamanaka YJ, Hahn WC, Wittrup KD, Love JC. Abstract C23: Functional characterization of viable circulating tumor cells using nanowells. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C23  0.451
2013 Hahn WC. Abstract IA5: Functional genomics and synthetic lethality Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-Ia5  0.518
2013 Baratta MG, Liu J, Zwang Y, Schinzel A, Drapkin R, Hahn W, Livingston DM. Abstract IA3: In tumor screening for novel targets in papillary serous ovarian cancer Clinical Cancer Research. 19. DOI: 10.1158/1078-0432.Ovca13-Ia3  0.466
2013 Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, ... ... Hahn WC, et al. Erratum: β-catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis (Cell (2012) 151 (1457-1473)) Cell. 153: 267-270. DOI: 10.1016/J.Cell.2013.03.007  0.373
2012 Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, ... ... Hahn WC, et al. β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell. 151: 1457-73. PMID 23245941 DOI: 10.1016/J.Cell.2012.11.026  0.471
2012 Quayle SN, Chheda MG, Shukla SA, Wiedemeyer R, Tamayo P, Dewan RW, Zhuang L, Huang-Hobbs E, Haidar S, Xiao Y, Ligon KL, Hahn WC, Chin L. Integrative functional genomics identifies RINT1 as a novel GBM oncogene. Neuro-Oncology. 14: 1325-31. PMID 23074196 DOI: 10.1093/Neuonc/Nos246  0.406
2012 Shen RR, Zhou AY, Kim E, Lim E, Habelhah H, Hahn WC. IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation. Molecular and Cellular Biology. 32: 4756-68. PMID 23007157 DOI: 10.1128/Mcb.00468-12  0.371
2012 Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, Harbour JW, Garraway LA, Kim IK. High throughput mass spectrometry-based mutation profiling of primary uveal melanoma. Investigative Ophthalmology & Visual Science. 53: 6991-6. PMID 22977135 DOI: 10.1167/Iovs.12-10427  0.348
2012 Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, ... ... Hahn WC, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proceedings of the National Academy of Sciences of the United States of America. 109: 14476-81. PMID 22908275 DOI: 10.1073/Pnas.1203201109  0.52
2012 Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, ... ... Hahn WC, et al. Cancer vulnerabilities unveiled by genomic loss. Cell. 150: 842-54. PMID 22901813 DOI: 10.1016/J.Cell.2012.07.023  0.47
2012 Ren Y, Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir BA, Boehm JS, Tamayo P, Karst AM, Liu JF, Hirsch MS, Mesirov JP, Drapkin R, Root DE, Lo J, ... ... Hahn WC, et al. Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Science Translational Medicine. 4: 147ra112. PMID 22896676 DOI: 10.1126/Scitranslmed.3003778  0.493
2012 Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Molecular and Cellular Biology. 32: 3963-77. PMID 22851694 DOI: 10.1128/Mcb.00436-12  0.309
2012 Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, ... ... Hahn WC, et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. Plos Genetics. 8: e1002772. PMID 22829774 DOI: 10.1371/Journal.Pgen.1002772  0.497
2012 Grisanzio C, Werner L, Takeda D, Awoyemi BC, Pomerantz MM, Yamada H, Sooriakumaran P, Robinson BD, Leung R, Schinzel AC, Mills I, Ross-Adams H, Neal DE, Kido M, Yamamoto T, ... ... Hahn WC, et al. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11252-7. PMID 22730461 DOI: 10.1073/Pnas.1200853109  0.397
2012 Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S. Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4. Blood. 120: 1095-106. PMID 22718837 DOI: 10.1182/Blood-2012-03-415984  0.421
2012 Bellucci R, Nguyen HN, Martin A, Heinrichs S, Schinzel AC, Hahn WC, Ritz J. Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. The Journal of Clinical Investigation. 122: 2369-83. PMID 22684105 DOI: 10.1172/Jci58457  0.421
2012 Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM. MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. Science Signaling. 5: rs4. PMID 22589389 DOI: 10.1126/Scisignal.2002612  0.405
2012 Wagle N, Berger MF, Davis MJ, Blumenstiel B, Defelice M, Pochanard P, Ducar M, Van Hummelen P, Macconaill LE, Hahn WC, Meyerson M, Gabriel SB, Garraway LA. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discovery. 2: 82-93. PMID 22585170 DOI: 10.1158/2159-8290.CD-11-0184  0.505
2012 Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, ... ... Hahn WC, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes & Development. 26: 756-84. PMID 22508724 DOI: 10.1101/Gad.187922.112  0.523
2012 Banerji V, Frumm SM, Ross KN, Li LS, Schinzel AC, Hahn CK, Kakoza RM, Chow KT, Ross L, Alexe G, Tolliday N, Inguilizian H, Galinsky I, Stone RM, DeAngelo DJ, ... ... Hahn WC, et al. The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. The Journal of Clinical Investigation. 122: 935-47. PMID 22326953 DOI: 10.1172/Jci46465  0.44
2012 Shrestha Y, Schafer EJ, Boehm JS, Thomas SR, He F, Du J, Wang S, Barretina J, Weir BA, Zhao JJ, Polyak K, Golub TR, Beroukhim R, Hahn WC. PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling. Oncogene. 31: 3397-408. PMID 22105362 DOI: 10.1038/Onc.2011.515  0.437
2012 Wright AA, Hirsch MS, Wagle N, Howitt BE, Palescandolo E, MacConaill LE, Hummelen PV, Shoni M, Hahn WC, Matulonis UA. KRAS and EGFR mutations to distinguish adenocarcinomas and squamous cell carcinomas of the cervix. Journal of Clinical Oncology. 30: 5011-5011. DOI: 10.1200/Jco.2012.30.15_Suppl.5011  0.415
2012 Riester M, Werner L, Molins JB, Selvarajah S, Weir B, Stack EC, Park RS, O'Brien R, Schutz FAB, Choueiri TK, Signoretti S, Gallardo E, Rojo F, Lloreta Trull J, Marchionni L, ... Hahn WC, et al. External validation of somatic copy number alteration (SCNA) at chromosome 1q23.3 in advanced urothelial carcinoma (UC). Journal of Clinical Oncology. 30: 4585-4585. DOI: 10.1200/Jco.2012.30.15_Suppl.4585  0.359
2012 Brastianos PK, Horowitz P, Santagata S, Jones RT, McKenna A, Ligon K, Palescandolo E, Van Hummelen P, Getz G, Hahn WC, Dunn IF, Beroukhim R. Genomic characterization of meningiomas. Journal of Clinical Oncology. 30: 2020-2020. DOI: 10.1200/Jco.2012.30.15_Suppl.2020  0.702
2012 Erlich RL, Palescandolo E, Jones RT, Sunkavalli A, Raza A, Ducar M, Hatton C, Go C, Roden C, Hanna M, Mills A, Adusumilli R, Kumar P, Brastianos PK, Meyerson ML, ... Hahn WC, et al. Massively parallel sequencing of formalin-fixed paraffin-embedded tissues Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S6-P40  0.591
2012 Huang X, Jayabalan D, Liberto MD, Harvey JD, Schinzel AC, Mark TM, Hussein M, Randolph S, Hahn WC, Niesvizky R, Chen-Kiang S. Synergistic Loss of IRF4 and Induction of IRF7 Sensitizes Primary Myeloma Cells to IMiD Killing by IFNβ in Prolonged Early G1 Arrest Induced by CDK4/CDK6 Inhibition Blood. 120: 572-572. DOI: 10.1182/Blood.V120.21.572.572  0.38
2012 Hahn WC. Abstract IA11: Functional genomics and KRAS-driven cancers. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Ia11  0.538
2012 Ren Y, Cheung HW, Drapkin R, Root D, Lo J, Fogal V, Ruoslahti E, Hahn W, Bhatia S, von Maltzahn G, Agrawal A, Cowley G, Weir B, Boehm J, Tamayo P, et al. Abstract PR5: Treatment of ovarian cancer with targeted tumor-penetrating siRNA nanocomplexes Cancer Research. 72: PR5-PR5. DOI: 10.1158/1538-7445.Nonrna12-Pr5  0.49
2012 Hahn WC. Abstract IA17: Functional genomics, small RNAs and cancer Cancer Research. 72: IA17-IA17. DOI: 10.1158/1538-7445.Nonrna12-Ia17  0.513
2012 Hahn WC. Abstract IA14: Functional genomics to identify cancer targets and resistance Clinical Cancer Research. 18: IA14-IA14. DOI: 10.1158/1538-7445.Csb12-Ia7  0.515
2012 Zhou AY, Shen RR, Kim E, Chen Z, Hahn WC. Abstract 4863: Ubiquitination of the breast cancer oncogene IKKα is essential for transformation Cancer Research. 72: 4863-4863. DOI: 10.1158/1538-7445.Am2012-4863  0.403
2012 Hatton C, Niu L, Davis M, Mondal C, Luongo L, Go C, Jones RT, Roden C, Palescandolo E, Hummelen PV, Garraway LA, Meyerson M, Hahn W, MacConaill LE. Abstract 3965: An algorithm to detect somatic mutations in cancer specimens using mass spectrometric genotyping Cancer Research. 72: 3965-3965. DOI: 10.1158/1538-7445.Am2012-3965  0.536
2011 Rosenberg JE, Werner L, Selvarajah S, Weir B, Regan MM, Jacobus SJ, Berman DM, Schutz FA, O'Brien R, Choueiri TK, Barretina J, Signoretti S, Loda M, Guancial EA, Gallardo E, ... ... Hahn WC, et al. Identification of a novel urothelial carcinoma (UC) biomarker of lethality. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 4569. PMID 28023354 DOI: 10.1200/Jco.2011.29.15_Suppl.4569  0.317
2011 Wagle N, Berger MF, Davis MJ, Blumenstiel B, DeFelice M, Hahn WC, Meyerson M, Gabriel SB, MacConaill LE, Garraway LA. Tumor genomic profiling of FFPE samples by massively parallel sequencing. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 10502. PMID 28022364 DOI: 10.1200/Jco.2011.29.15_Suppl.10502  0.512
2011 Cheung HW, Du J, Boehm JS, He F, Weir BA, Wang X, Butaney M, Sequist LV, Luo B, Engelman JA, Root DE, Meyerson M, Golub TR, Jänne PA, Hahn WC. Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discovery. 1: 608-25. PMID 22586683 DOI: 10.1158/2159-8290.Cd-11-0046  0.549
2011 MacConaill LE, Van Hummelen P, Meyerson M, Hahn WC. Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges. Cancer Discovery. 1: 297-311. PMID 21935500 DOI: 10.1158/2159-8290.Cd-11-0110  0.594
2011 Matulonis UA, Hirsch M, Palescandolo E, Kim E, Liu J, van Hummelen P, MacConaill L, Drapkin R, Hahn WC. High throughput interrogation of somatic mutations in high grade serous cancer of the ovary. Plos One. 6: e24433. PMID 21931712 DOI: 10.1371/Journal.Pone.0024433  0.414
2011 Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, ... ... Hahn WC, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/Ng.936  0.594
2011 Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, ... ... Hahn WC, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 146: 904-17. PMID 21889194 DOI: 10.1016/J.Cell.2011.08.017  0.397
2011 Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, ... ... Hahn WC, et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 12372-7. PMID 21746896 DOI: 10.1073/Pnas.1109363108  0.641
2011 Okamoto N, Yasukawa M, Nguyen C, Kasim V, Maida Y, Possemato R, Shibata T, Ligon KL, Fukami K, Hahn WC, Masutomi K. Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proceedings of the National Academy of Sciences of the United States of America. 108: 20388-93. PMID 21730156 DOI: 10.1073/Pnas.1015171108  0.43
2011 Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, ... ... Hahn WC, et al. A public genome-scale lentiviral expression library of human ORFs. Nature Methods. 8: 659-61. PMID 21706014 DOI: 10.1038/Nmeth.1638  0.354
2011 Lund P, Kotova I, Kedinger V, Khanwalkar H, Voltz E, Hahn WC, Gronemeyer H. Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine. Molecular Cancer Therapeutics. 10: 1611-23. PMID 21697397 DOI: 10.1158/1535-7163.Mct-11-0140  0.338
2011 Boehm JS, Hahn WC. Towards systematic functional characterization of cancer genomes. Nature Reviews. Genetics. 12: 487-98. PMID 21681210 DOI: 10.1038/Nrg3013  0.44
2011 Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, ... ... Hahn WC, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. The Journal of Clinical Investigation. 121: 2723-35. PMID 21633165 DOI: 10.1172/Jci44745  0.406
2011 Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, ... ... Hahn WC, et al. Initial genome sequencing and analysis of multiple myeloma. Nature. 471: 467-72. PMID 21430775 DOI: 10.1038/Nature09837  0.571
2011 Chin L, Hahn WC, Getz G, Meyerson M. Making sense of cancer genomic data. Genes & Development. 25: 534-55. PMID 21406553 DOI: 10.1101/Gad.2017311  0.575
2011 Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M, Garraway LA. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3085-96. PMID 21383288 DOI: 10.1200/Jco.2010.33.2312  0.556
2011 Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, dal Zuffo R, Matti V, d'Ario G, Montani E, Mercurio C, Hahn WC, Gorgoulis V, Minucci S, d'Adda di Fagagna F. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature Cell Biology. 13: 292-302. PMID 21336312 DOI: 10.1038/Ncb2170  0.415
2011 Shen RR, Hahn WC. Emerging roles for the non-canonical IKKs in cancer. Oncogene. 30: 631-41. PMID 21042276 DOI: 10.1038/Onc.2010.493  0.438
2011 Boehm JS, Hahn WC. Immortalized cells as experimental models to study cancer. Cytotechnology. 45: 47-59. PMID 19003243 DOI: 10.1007/S10616-004-5125-1  0.492
2011 Issa GC, Delmore JE, McKeown MR, Lemieux ME, Rahl PB, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Shi J, Chesi M, Schinzel AC, Vakoc CR, Bergsagel P, ... ... Hahn WC, et al. Inhibition of c-Myc Expression and Function in Hematologic Malignancies Blood. 118: 1409-1409. DOI: 10.1182/Blood.V118.21.1409.1409  0.348
2011 Hahn WC. Abstract PL01-01: Advances in functional cancer genomics Cancer Prevention Research. 4. DOI: 10.1158/1940-6207.Prev-11-Pl01-01  0.498
2011 Hahn WC. Abstract SY25-01: Functional genomics, transformation, and resistance Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy25-01  0.527
2011 Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M, Garraway LA. Abstract 3933: Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling Cancer Research. 71: 3933-3933. DOI: 10.1158/1538-7445.Am2011-3933  0.572
2011 Hahn WC. Abstract CN02-01: Functional genomics to identify targets and resistance. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-Cn02-01  0.514
2010 Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, ... ... Hahn WC, et al. Therapeutic implications of GIPC1 silencing in cancer. Plos One. 5: e15581. PMID 21209904 DOI: 10.1371/Journal.Pone.0015581  0.482
2010 Sablina AA, Hector M, Colpaert N, Hahn WC. Identification of PP2A complexes and pathways involved in cell transformation. Cancer Research. 70: 10474-84. PMID 21159657 DOI: 10.1158/0008-5472.Can-10-2855  0.358
2010 Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, ... ... Hahn WC, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 468: 968-72. PMID 21107320 DOI: 10.1038/Nature09627  0.358
2010 Pomerantz MM, Shrestha Y, Flavin RJ, Regan MM, Penney KL, Mucci LA, Stampfer MJ, Hunter DJ, Chanock SJ, Schafer EJ, Chan JA, Tabernero J, Baselga J, Richardson AL, Loda M, ... ... Hahn WC, et al. Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis. Plos Genetics. 6: e1001204. PMID 21085629 DOI: 10.1371/Journal.Pgen.1001204  0.352
2010 Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro SB, Mollah SA, Shabanowitz J, Hunt DF, Xenarios I, Hahn WC, Conaway M, Carey MF, Gioeli D. CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation. Molecular Endocrinology (Baltimore, Md.). 24: 2267-80. PMID 20980437 DOI: 10.1210/Me.2010-0238  0.331
2010 Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. The Journal of Clinical Investigation. 120: 3940-52. PMID 20972333 DOI: 10.1172/Jci44165  0.516
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, ... ... Hahn WC, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/Nbt0910-904  0.491
2010 Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, et al. PTK6 regulates IGF-1-induced anchorage-independent survival. Plos One. 5: e11729. PMID 20668531 DOI: 10.1371/Journal.Pone.0011729  0.411
2010 Garraway LA, Hahn WC. On or off target: mutations, models, and predictions. Science Translational Medicine. 2: 35ps28. PMID 20538617 DOI: 10.1126/Scitranslmed.3001263  0.336
2010 Wiedemeyer WR, Dunn IF, Quayle SN, Zhang J, Chheda MG, Dunn GP, Zhuang L, Rosenbluh J, Chen S, Xiao Y, Shapiro GI, Hahn WC, Chin L. Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Proceedings of the National Academy of Sciences of the United States of America. 107: 11501-6. PMID 20534551 DOI: 10.1073/Pnas.1001613107  0.605
2010 Moody SE, Boehm JS, Barbie DA, Hahn WC. Functional genomics and cancer drug target discovery. Current Opinion in Molecular Therapeutics. 12: 284-93. PMID 20521217  0.397
2010 Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 116: 1919-23. PMID 20519626 DOI: 10.1182/Blood-2010-04-279083  0.535
2010 Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, ... ... Hahn WC, et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 17: 497-509. PMID 20478531 DOI: 10.1016/J.Ccr.2010.03.020  0.364
2010 Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Schoeberl B, ... ... Hahn WC, et al. An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell. 17: 298-310. PMID 20227043 DOI: 10.1016/J.Ccr.2009.12.047  0.613
2010 Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. An oncogenic role for ETV1 in melanoma. Cancer Research. 70: 2075-84. PMID 20160028 DOI: 10.1158/0008-5472.Can-09-3092  0.442
2010 Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nature Medicine. 16: 286-94. PMID 20154697 DOI: 10.1038/Nm.2100  0.416
2010 Kim SY, Dunn IF, Firestein R, Gupta P, Wardwell L, Repich K, Schinzel AC, Wittner B, Silver SJ, Root DE, Boehm JS, Ramaswamy S, Lander ES, Hahn WC. CK1epsilon is required for breast cancers dependent on beta-catenin activity. Plos One. 5: e8979. PMID 20126544 DOI: 10.1371/Journal.Pone.0008979  0.559
2010 Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Molecular Biology of the Cell. 21: 1140-52. PMID 20110348 DOI: 10.1091/Mbc.E09-09-0795  0.301
2010 Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, Giovannucci EL, Hahn WC, Fuchs CS, Ogino S. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. International Journal of Cancer. Journal International Du Cancer. 126: 2863-73. PMID 19790197 DOI: 10.1002/Ijc.24908  0.415
2010 MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, ... ... Hahn WC, et al. Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples Plos One. 5. DOI: 10.1371/Annotation/3A0C8Fee-57Ef-43Ed-B6C2-55B503E6Db5E  0.382
2010 Banerji V, Ross KN, Li LS, Frumm SM, Schinzel AC, Hahn CK, Kakoza RM, Chow KT, Ross L, Inguilizian H, Galinsky I, Stone RM, DeAngelo DJ, Hahn WC, Kung AL, et al. Intersecting Chemical Genomic and Genetic Screens Identifies Glycogen Synthase Kinase-3α (GSK-3α) as a Modulator of Differentiation In Acute Myeloid Leukemia Blood. 116: 1000-1000. DOI: 10.1182/Blood.V116.21.1000.1000  0.377
2010 Wagle N, Davis M, Berger MF, Blumenstiel B, Defelice M, Hahn W, Meyerson M, Gabriel SB, MacConaill L, Garraway LA. Abstract LB-122: High-throughput tumor genomic profiling by massively parallel sequencing Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-122  0.593
2010 Jane-Valbuena J, Widlund H, Perner S, Johnson L, Dibner A, Lin W, Baker A, Nazarian R, Vijayendran K, Sellers W, Hahn W, Duncan L, Rubin M, Fisher D, Garraway LA. Abstract 3111: The ETS factor ETV1 is an oncogene in melanoma Cancer Research. 70: 3111-3111. DOI: 10.1158/1538-7445.Am10-3111  0.455
2010 Hahn WC. Abstract IA1-1: Systematic functional genomics and cancer target identification and validation Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-Ia1-1  0.537
2010 Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Kung BSAL, ... Hahn WC, et al. An Activated ErbB3/NRG1 Autocrine Loop Supports In Vivo Proliferation in Ovarian Cancer Cells (DOI:10.1016/j.ccr.2009.12.047) Cancer Cell. 17: 412. DOI: 10.1016/j.ccr.2010.03.014  0.513
2009 MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, ... ... Hahn WC, et al. Profiling critical cancer gene mutations in clinical tumor samples. Plos One. 4: e7887. PMID 19924296 DOI: 10.1371/Journal.Pone.0007887  0.556
2009 Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 16: 413-24. PMID 19878873 DOI: 10.1016/J.Ccr.2009.09.029  0.372
2009 Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, ... ... Hahn WC, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462: 108-12. PMID 19847166 DOI: 10.1038/Nature08460  0.761
2009 Firestein R, Hahn WC. Revving the Throttle on an oncogene: CDK8 takes the driver seat. Cancer Research. 69: 7899-901. PMID 19808961 DOI: 10.1158/0008-5472.Can-09-1704  0.343
2009 Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, ... ... Hahn WC, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics. 41: 1238-42. PMID 19801978 DOI: 10.1038/Ng.465  0.562
2009 Hahn CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K, Schinzel AC, Ross L, Galinsky I, Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M, Hahn WC, et al. Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell. 16: 281-94. PMID 19800574 DOI: 10.1016/J.Ccr.2009.08.018  0.384
2009 Balakumaran BS, Porrello A, Hsu DS, Glover W, Foye A, Leung JY, Sullivan BA, Hahn WC, Loda M, Febbo PG. MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. Cancer Research. 69: 7803-10. PMID 19773438 DOI: 10.1158/0008-5472.Can-09-0910  0.422
2009 Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ. SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. Science Signaling. 2: ra35. PMID 19622832 DOI: 10.1126/Scisignal.2000369  0.415
2009 Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, ... ... Hahn WC, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 16: 21-32. PMID 19573809 DOI: 10.1016/J.Ccr.2009.04.012  0.716
2009 Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, ... ... Hahn WC, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell. 137: 821-34. PMID 19490892 DOI: 10.1016/J.Cell.2009.03.017  0.725
2009 Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Molecular Cell. 34: 461-72. PMID 19481526 DOI: 10.1016/J.Molcel.2009.04.031  0.405
2009 Hahn WC, Dunn IF, Kim SY, Schinzel AC, Firestein R, Guney I, Boehm JS. Integrative genomic approaches to understanding cancer. Biochimica Et Biophysica Acta. 1790: 478-84. PMID 19364473 DOI: 10.1016/J.Bbagen.2009.02.003  0.644
2009 Loda M, Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, Fiore C, Xie W, Kung AL, Febbo PG, ... ... Hahn WC, et al. Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer Journal of the National Cancer Institute. 101: 519-532. PMID 19318631 DOI: 10.1093/Jnci/Djp030  0.351
2009 Rosenberg JE, Hahn WC. Bladder cancer: Modeling and translation Genes and Development. 23: 655-659. PMID 19299556 DOI: 10.1101/Gad.1789109  0.427
2009 Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma Cancer Research. 69: 2870-2877. PMID 19293187 DOI: 10.1158/0008-5472.Can-08-2760  0.358
2009 Downward J, Hahn WC. Genetic and cellular mechanisms of oncogenesis Current Opinion in Genetics and Development. 19: 1-3. PMID 19208465 DOI: 10.1016/J.Gde.2009.01.001  0.474
2009 MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, ... ... Hahn WC, et al. Correction: Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples Plos One. 4. DOI: 10.1371/annotation/613c7509-e4c9-42ac-82fb-fc504400d9e0  0.509
2009 Chapman MA, Brunet J, Keats JJ, Baker A, Adli M, Schinzel AC, Ahmann G, Christina H, Moore A, Shanmugam V, Perkins LM, Auclair D, Hahn WC, Bernstein BE, Bergsagel L, et al. HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma. Blood. 114: 832-832. DOI: 10.1182/Blood.V114.22.832.832  0.359
2009 Bellucci R, Nguyen H, Martin A, Schinzel AC, Heinrichs S, Hahn WC, Ritz J. NOVEL Pathways Modulate TUMOR CELL Susceptibility to NK CELLS. Blood. 114: 277-277. DOI: 10.1182/Blood.V114.22.277.277  0.413
2009 Greulich H, Chheda M, Chen T, Tanaka K, Dutt A, Wong K, Hahn W, Meyerson M. Abstract A199: Oncogenic and drug‐sensitive ERBB2 mutations in glioblastoma Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A199  0.566
2009 Maida Y, Hayashizaki Y, Masutomi K, Hahn WC. Abstract IA-23: TERT, senescence, and transformation Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-Ia-23  0.329
2009 Shrestha Y, Schafer EJ, Weir B, Boehm J, Thomas S, Hahn WC. Abstract A38: Human kinase screen for breast cancer oncogenes Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-A38  0.418
2009 Boehm JS, Cowley G, Weir B, Barretina J, Luo B, Cheung HW, Rusin S, Scott J, Derr A, Tsherniak A, Gopalakrishnan S, Tamayo P, Barbie D, Yang X, Piqani B, ... ... Hahn WC, et al. Abstract A23: An integrated platform for the functional annotation of the cancer genome Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-A23  0.636
2009 Greulich H, Chheda M, Chen T, Tanaka K, Dutt A, Wong K, Hahn W, Meyerson M. Abstract A2: Oncogenic and drug‐sensitiveERBB2mutations in glioblastoma Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-A2  0.573
2008 Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, ... ... Hahn WC, et al. Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 20380-5. PMID 19091943 DOI: 10.1073/Pnas.0810485105  0.65
2008 Jeong JH, Wang Z, Guimaraes AS, Ouyang X, Figueiredo JL, Ding Z, Jiang S, Guney I, Kang GH, Shin E, Hahn WC, Loda MF, Abate-Shen C, Weissleder R, Chin L. BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. Plos One. 3: e3949. PMID 19079609 DOI: 10.1371/Journal.Pone.0003949  0.351
2008 Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, ... ... Hahn WC, et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 19372-7. PMID 19050074 DOI: 10.1073/Pnas.0809966105  0.627
2008 Possemato R, Timmons JC, Bauerlein EL, Wada N, Baldwin A, Masutomi K, Hahn WC. Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics Molecular Cancer Research. 6: 1582-1593. PMID 18922974 DOI: 10.1158/1541-7786.Mcr-08-0070  0.353
2008 Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, ... ... Hahn WC, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 455: 547-51. PMID 18794900 DOI: 10.1038/Nature07179  0.665
2008 Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek WK, Wang S, Ellwood-Yen K, Wu H, ... ... Hahn WC, et al. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell. 14: 146-55. PMID 18691549 DOI: 10.1016/J.Ccr.2008.06.002  0.391
2008 Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, et al. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 13: 394-406. PMID 18455123 DOI: 10.1016/J.Ccr.2008.03.007  0.351
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/Journal.Pone.0002020  0.406
2008 Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, et al. Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell. 13: 355-64. PMID 18394558 DOI: 10.1016/J.Ccr.2008.02.010  0.33
2008 Westermarck J, Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation Trends in Molecular Medicine. 14: 152-160. PMID 18329957 DOI: 10.1016/J.Molmed.2008.02.001  0.428
2008 Lee J, Sung YH, Cheong C, Choi YS, Jeon HK, Sun W, Hahn WC, Ishikawa F, Lee HW. TERT promotes cellular and organismal survival independently of telomerase activity Oncogene. 27: 3754-3760. PMID 18223679 DOI: 10.1038/Sj.Onc.1211037  0.318
2008 Sablina AA, Hahn WC. SV40 small T antigen and PP2A phosphatase in cell transformation Cancer and Metastasis Reviews. 27: 137-146. PMID 18214640 DOI: 10.1007/S10555-008-9116-0  0.419
2008 Pienta KJ, Abate-Shen C, Agus DB, Attar RM, Chung LW, Greenberg NM, Hahn WC, Isaacs JT, Navone NM, Peehl DM, Simons JW, Solit DB, Soule HR, VanDyke TA, Weber MJ, et al. The current state of preclinical prostate cancer animal models. The Prostate. 68: 629-39. PMID 18213636 DOI: 10.1002/Pros.20726  0.387
2008 Schinzel AC, Hahn WC. Oncogenic transformation and experimental models of human cancer Frontiers in Bioscience. 13: 71-84. PMID 17981529 DOI: 10.2741/2661  0.499
2008 Chapman MA, Brunet J, Baker A, Keats J, Ahmann G, Schinzel AC, Moore A, Shanmugam V, Perkins LM, Auclair D, Hahn WC, Bergsagel PL, Fonseca R, Carpten J, Trent J, et al. Interim Analyses of the MMRC Reference Collection Identifies Recurrent Genomic-Level Events in Multiple Myeloma and Demonstrates That CDKN2C/p18 Deletion Is the Pre-Eminent Copy Number Alteration in Poor Prognosis Disease Blood. 112: 497-497. DOI: 10.1182/Blood.V112.11.497.497  0.415
2008 Scholl C, Frohling S, Dunn IF, Barbie DA, Schinzel AC, Kim SY, Silver SJ, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG. High-Throughput RNA Interference Screening Identifies Synthetic Lethality Between Oncogenic KRAS Dependency and Suppression of STK33 Blood. 112: 3806-3806. DOI: 10.1182/Blood.V112.11.3806.3806  0.684
2008 Bellucci R, Nguyen H, Martin A, Schinzel A, Daley J, Hansen S, Hahn WC, Ritz J. Genetic Screening for Myeloma Cell Susceptibility to NK Cell Mediated Lysis Using Large Lentiviral shRNA Libraries Blood. 112: 2900-2900. DOI: 10.1182/Blood.V112.11.2900.2900  0.413
2007 Sablina AA, Hahn WC. The role of PP2A A subunits in tumor suppression Cell Adhesion & Migration. 1: 140-141. PMID 19262135 DOI: 10.4161/Cam.1.3.4986  0.411
2007 Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & Development. 21: 2683-710. PMID 17974913 DOI: 10.1101/Gad.1596707  0.393
2007 Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, ... ... Hahn WC, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 129: 1065-79. PMID 17574021 DOI: 10.1016/J.Cell.2007.03.052  0.694
2007 Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC. The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase Cell. 129: 969-982. PMID 17540176 DOI: 10.1016/J.Cell.2007.03.047  0.406
2007 Kim SY, Hahn WC. Cancer genomics: Integrating form and function Carcinogenesis. 28: 1387-1392. PMID 17434922 DOI: 10.1093/Carcin/Bgm086  0.423
2007 Nieto M, Finn S, Loda M, Hahn WC. Prostate cancer: Re-focusing on androgen receptor signaling International Journal of Biochemistry and Cell Biology. 39: 1562-1568. PMID 17321194 DOI: 10.1016/J.Biocel.2007.01.005  0.379
2007 Schinzel AC, Chapman M, Wittner B, Shrestha Y, Ramaswamy S, Golub TR, Hahn WC. A High-Throughput Arrayed Lentiviral RNAi Screen To Identify Novel Oncogenes in Multiple Myeloma. Blood. 110: 4770-4770. DOI: 10.1182/Blood.V110.11.4770.4770  0.403
2006 Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 10: 321-30. PMID 17010675 DOI: 10.1016/J.Ccr.2006.09.005  0.382
2006 Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods. 3: 777-9. PMID 16990807 DOI: 10.1038/Nmeth1006-777  0.489
2006 Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods. 3: 715-9. PMID 16929317 DOI: 10.1038/Nmeth924  0.326
2006 Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 442: 818-22. PMID 16862118 DOI: 10.1038/Nature04980  0.396
2006 Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, Flotte TJ, Duncan LM, Granter SR, Chin L. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 125: 1269-81. PMID 16814714 DOI: 10.1016/J.Cell.2006.06.008  0.436
2006 Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M. Androgen-dependent regulation of Her-2/neu in prostate cancer cells. Cancer Research. 66: 5723-8. PMID 16740710 DOI: 10.1158/0008-5472.Can-05-3928  0.385
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, ... Hahn WC, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/J.Cell.2006.01.040  0.397
2006 Polyak K, Hahn WC. Roots and stems: Stem cells in cancer Nature Medicine. 12: 296-300. PMID 16520777 DOI: 10.1038/Nm1379  0.491
2005 Elliston KO, Pratt D, Hahn W, Febbo P. Identification of the androgen-induced transcriptional program of human prostate cancer revealed by causal analysis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 4637. PMID 27947009 DOI: 10.1200/Jco.2005.23.16_Suppl.4637  0.355
2005 Arroyo JD, Hahn WC. Involvement of PP2A in viral and cellular transformation Oncogene. 24: 7746-7755. PMID 16299534 DOI: 10.1038/Sj.Onc.1209038  0.435
2005 Goessel G, Quante M, Hahn WC, Karada H, Heeg S, Suliman Y, Doebele M, Von Werder A, Fulda C, Nakagawa H, Rustgi AK, Blum HE, Opitz OG. Creating oral squamous cancer cells: A cellular model of oral-esophageal carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. 102: 15599-15604. PMID 16239349 DOI: 10.1073/Pnas.0409730102  0.439
2005 Yu EY, Hahn WC. The origin of cancer. Cancer Treatment and Research. 122: 1-22. PMID 16209036 DOI: 10.1007/1-4020-8107-3_1  0.418
2005 Greulich H, Chen TH, Feng W, Jänne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. Plos Medicine. 2: e313. PMID 16187797 DOI: 10.1371/Journal.Pmed.0020313  0.514
2005 Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC. Cancer-associated PP2A Aα subunits induce functional haploinsufficiency and tumorigenicity Cancer Research. 65: 8183-8192. PMID 16166293 DOI: 10.1158/0008-5472.Can-05-1103  0.47
2005 Boehm JS, Hahn WC. Cancer genetics: Finding the right mix European Journal of Human Genetics : Ejhg. 13: 1099-1100. PMID 16077731 DOI: 10.1038/Sj.Ejhg.5201477  0.362
2005 Boehm JS, Hession MT, Bulmer SE, Hahn WC. Transformation of human and murine fibroblasts without viral oncoproteins Molecular and Cellular Biology. 25: 6464-6474. PMID 16024784 DOI: 10.1128/Mcb.25.15.6464-6474.2005  0.35
2005 Nakamura M, Masutomi K, Kyo S, Hashimoto M, Maida Y, Kanaya T, Tanaka M, Hahn WC, Inoue M. Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy. Human Gene Therapy. 16: 859-68. PMID 16000067 DOI: 10.1089/Hum.2005.16.859  0.448
2005 Hahn WC. Telomere and telomerase dynamics in human cells Current Molecular Medicine. 5: 227-231. PMID 15974877 DOI: 10.2174/1566524053586572  0.414
2005 Hashimoto M, Kyo S, Masutomi K, Maida Y, Sakaguchi J, Mizumoto Y, Nakamura M, Hahn WC, Inoue M. Analysis of telomeric single-strand overhang length in human endometrial cancers Febs Letters. 579: 2959-2964. PMID 15893755 DOI: 10.1016/J.Febslet.2005.04.021  0.42
2005 Yu EY, Hahn WC. Genetic alterations in prostate cancer Clinical Prostate Cancer. 3: 220-229. PMID 15882478 DOI: 10.3816/Cgc.2005.N.003  0.376
2005 Dong CK, Masutomi K, Hahn WC. Telomerase: regulation, function and transformation. Critical Reviews in Oncology/Hematology. 54: 85-93. PMID 15843091 DOI: 10.1016/J.Critrevonc.2004.12.005  0.379
2005 Boehm JS, Hahn WC. Understanding transformation: progress and gaps. Current Opinion in Genetics & Development. 15: 13-7. PMID 15661528 DOI: 10.1016/J.Gde.2004.11.003  0.486
2005 Goessel G, Quante M, von Werder A, Heeg S, Doebele M, Doebele M, Fulda C, Nakagawa H, Suliman Y, Rustgi A, Hahn W, Blum H, Opitz O. Malignant transformation of primary human oral squamous epithelial cells using a defined set of genetic alterations Zeitschrift FüR Gastroenterologie. 43. DOI: 10.1055/S-2005-919794  0.312
2004 Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Research. 64: 8867-75. PMID 15604246 DOI: 10.1158/0008-5472.Can-04-2938  0.314
2004 Moreno CS, Ramachandran S, Ashby DG, Laycock N, Plattner CA, Chen W, Hahn WC, Pallas DC. Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdown. Cancer Research. 64: 6978-88. PMID 15466190 DOI: 10.1158/0008-5472.Can-04-1150  0.399
2004 Hahn WC. Cancer: surviving on the edge. Cancer Cell. 6: 215-22. PMID 15380512 DOI: 10.1016/J.Ccr.2004.09.007  0.507
2004 Zhao JJ, Roberts TM, Hahn WC. Functional genetics and experimental models of human cancer. Trends in Molecular Medicine. 10: 344-50. PMID 15242683 DOI: 10.1016/J.Molmed.2004.05.005  0.49
2004 Satyanarayana A, Greenberg RA, Schaetzlein S, Buer J, Masutomi K, Hahn WC, Zimmermann S, Martens U, Manns MP, Rudolph KL. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling. Molecular and Cellular Biology. 24: 5459-74. PMID 15169907 DOI: 10.1128/Mcb.24.12.5459-5474.2004  0.324
2004 Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, Counter CM, Nevins JR, Means AR, Sears R. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nature Cell Biology. 6: 308-18. PMID 15048125 DOI: 10.1038/Ncb1110  0.593
2004 Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC. Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell. 5: 127-36. PMID 14998489 DOI: 10.1016/S1535-6108(04)00026-1  0.396
2004 Liu J, Yang G, Thompson-Lanza JA, Glassman A, Hayes K, Patterson A, Marquez RT, Auersperg N, Yu Y, Hahn WC, Mills GB, Bast RC. A genetically defined model for human ovarian cancer. Cancer Research. 64: 1655-63. PMID 14996724 DOI: 10.1158/0008-5472.Can-03-3380  0.468
2004 Hahn WC. Targeting cancer with telomerase: commentary re Q. Huang et al., a novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. Clin. Cancer Res., 10: 1439-1445, 2004. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1203-5. PMID 14977815 DOI: 10.1158/1078-0432.Ccr-04-0060  0.381
2004 Vonderheide RH, Domchek SM, Schultze JL, George DJ, Hoar KM, Chen DY, Stephans KF, Masutomi K, Loda M, Xia Z, Anderson KS, Hahn WC, Nadler LM. Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 828-39. PMID 14871958 DOI: 10.1158/1078-0432.Ccr-0620-3  0.447
2004 Baykal A, Thompson JA, Xu XC, Hahn WC, Deavers MT, Malpica A, Gershenson DM, Silva EG, Liu J. In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues. Oncology Reports. 11: 297-302. PMID 14719058 DOI: 10.3892/Or.11.2.297  0.377
2004 Blasco MA, Hahn WC. Evolving views of telomerase and cancer. Trends in Cell Biology. 13: 289-94. PMID 12791294 DOI: 10.1016/S0962-8924(03)00085-0  0.442
2004 Schmutzler R, Schwarz-Boeger U, Bastert G, Bender, Beckmann, Caffier, Crohns, Deininger J, Dietl, Ditsch, Distler, Estevez-Schwarz, Hahn W, Herroder, Hubbel, et al. Indications for BRCA1 and BRCA2 mutation testing in hereditary breast and ovarian cancer families Journal of Clinical Oncology. 22: 9720-9720. DOI: 10.1200/Jco.2004.22.90140.9720  0.352
2003 Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC. Telomerase maintains telomere structure in normal human cells. Cell. 114: 241-53. PMID 12887925 DOI: 10.1016/S0092-8674(03)00550-6  0.532
2003 Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell. 3: 483-95. PMID 12781366 DOI: 10.1016/S1535-6108(03)00088-6  0.322
2003 Masutomi K, Hahn WC. Telomerase and tumorigenesis. Cancer Letters. 194: 163-72. PMID 12757974 DOI: 10.1016/S0304-3835(02)00703-6  0.425
2003 Hahn WC. Role of telomeres and telomerase in the pathogenesis of human cancer Journal of Clinical Oncology. 21: 2034-2043. PMID 12743159 DOI: 10.1200/Jco.2003.06.018  0.357
2003 Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 3: 285-96. PMID 12676586 DOI: 10.1016/S1535-6108(03)00050-3  0.341
2003 Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM. Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Molecular and Cellular Biology. 23: 2859-70. PMID 12665584 DOI: 10.1128/Mcb.23.8.2859-2870.2003  0.378
2003 Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, Weinberg RA. Erosion of the telomeric single-strand overhang at replicative senescence. Nature Genetics. 33: 492-6. PMID 12652299 DOI: 10.1038/Ng1127  0.506
2003 Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. Rna (New York, N.Y.). 9: 493-501. PMID 12649500 DOI: 10.1261/Rna.2192803  0.552
2003 Hahn WC. Senescence, telomere shortening and telomere maintenance. Cancer Biology & Therapy. 1: 398-400. PMID 12432254 DOI: 10.4161/Cbt.1.4.14  0.326
2003 Masutomi K, Hahn WC. Telomerase expression--only half the story. Cancer Biology & Therapy. 2: 685-686. DOI: 10.4161/Cbt.2.6.569  0.428
2002 Hahn WC, Weinberg RA. Rules for making human tumor cells New England Journal of Medicine. 347: 1593-1603. PMID 12432047 DOI: 10.1056/Nejmra021902  0.596
2002 Stewart SA, Hahn WC, O'Connor BF, Banner EN, Lundberg AS, Modha P, Mizuno H, Brooks MW, Fleming M, Zimonjic DB, Popescu NC, Weinberg RA. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 99: 12606-11. PMID 12193655 DOI: 10.1073/Pnas.182407599  0.542
2002 Stewart SA, Hahn WC. Prospects for anti-neoplastic therapies based on telomere biology. Current Cancer Drug Targets. 2: 1-17. PMID 12188917 DOI: 10.2174/1568009023334015  0.393
2002 Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nature Medicine. 8: 979-86. PMID 12185362 DOI: 10.1038/Nm754  0.329
2002 Lundberg AS, Randell SH, Stewart SA, Elenbaas B, Hartwell KA, Brooks MW, Fleming MD, Olsen JC, Miller SW, Weinberg RA, Hahn WC. Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene. 21: 4577-86. PMID 12085236 DOI: 10.1038/Sj.Onc.1205550  0.567
2002 Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O'Toole KM. A two-stage, p16INK4A- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status Molecular and Cellular Biology. 22: 5157-5172. PMID 12077343 DOI: 10.1128/Mcb.22.14.5157-5172.2002  0.303
2002 Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer Nature Reviews Cancer. 2: 331-341. PMID 12044009 DOI: 10.1038/Nrc795  0.592
2002 Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Molecular and Cellular Biology. 22: 2111-23. PMID 11884599 DOI: 10.1128/Mcb.22.7.2111-2123.2002  0.57
2001 Opitz OG, Suliman Y, Hahn WC, Harada H, Blum HE, Rustgi AK. Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism Journal of Clinical Investigation. 108: 725-732. PMID 11544278 DOI: 10.1016/S0016-5085(08)81445-X  0.318
2001 Hahn WC, Meyerson M. Telomerase activation, cellular immortalization and cancer Annals of Medicine. 33: 123-129. PMID 11327115 DOI: 10.3109/07853890109002067  0.585
2001 Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L. The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. The Embo Journal. 20: 905-13. PMID 11179234 DOI: 10.1093/Emboj/20.4.905  0.32
2001 Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Donaher JL, Popescu NC, Hahn WC, Weinberg RA. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes & Development. 15: 50-65. PMID 11156605 DOI: 10.1101/gad.828901  0.548
2001 Hahn W, Elenbaas B, Stewart S, Watnick R, Yang J, Mani S, Weinberg R. Rules governing the creation of human tumor cells European Journal of Cancer. 37: S369. DOI: 10.1016/S0959-8049(01)81861-X  0.673
2000 Lundberg AS, Hahn WC, Gupta P, Weinberg RA. Genes involved in senescence and immortalization. Current Opinion in Cell Biology. 12: 705-9. PMID 11063935 DOI: 10.1016/S0955-0674(00)00155-1  0.509
2000 Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA, Louis DN, Li FP, Rheinwald JG. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Molecular and Cellular Biology. 20: 1436-47. PMID 10648628 DOI: 10.1128/Mcb.20.4.1436-1447.2000  0.52
1999 Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA. Inhibition of telomerase limits the growth of human cancer cells. Nature Medicine. 5: 1164-70. PMID 10502820 DOI: 10.1038/13495  0.663
1999 Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature. 400: 464-8. PMID 10440377 DOI: 10.1038/22780  0.719
1999 Vonderheide RH, Hahn WC, Schultze JL, Nadler LM. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes Immunity. 10: 673-679. PMID 10403642 DOI: 10.1016/S1074-7613(00)80066-7  0.394
1998 Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proceedings of the National Academy of Sciences of the United States of America. 95: 14723-8. PMID 9843956 DOI: 10.1073/Pnas.95.25.14723  0.686
1993 Hahn WC, Menzin E, Saito T, Germain RN, Bierer BE. The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines. Gene. 127: 267-8. PMID 8500769 DOI: 10.1016/0378-1119(93)90731-H  0.305
Low-probability matches (unlikely to be authored by this person)
1987 Rheinwald JG, Jorgensen JL, Hahn WC, Terpstra AJ, O'Connell TM, Plummer KK. Mesosecrin: a secreted glycoprotein produced in abundance by human mesothelial, endothelial, and kidney epithelial cells in culture. The Journal of Cell Biology. 104: 263-75. PMID 3543023 DOI: 10.1083/Jcb.104.2.263  0.298
2008 Arroyo JD, Lee GM, Hahn WC. Liprinα1 interacts with PP2A B56γ Cell Cycle. 7: 525-532. PMID 18235218 DOI: 10.4161/Cc.7.4.5390  0.298
2023 Salahudeen AA, Seoane JA, Yuki K, Mah AT, Smith AR, Kolahi K, De la O SM, Hart DJ, Ding J, Ma Z, Barkal SA, Shukla ND, Zhang CH, Cantrell MA, Batish A, ... ... Hahn WC, et al. Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis. Cell Reports. 42: 113355. PMID 37922313 DOI: 10.1016/j.celrep.2023.113355  0.297
2015 Hettmer S, Schinzel AC, Tchessalova D, Schneider M, Parker CL, Bronson RT, Richards NG, Hahn WC, Wagers AJ. Author response: Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma Elife. DOI: 10.7554/Elife.09436.022  0.295
2003 Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG. Chemosensitivity linked to p73 function Cancer Cell. 3: 403-410. PMID 12726865 DOI: 10.1016/S1535-6108(03)00078-3  0.294
2008 Cichowski K, Hahn WC. Unexpected Pieces to the Senescence Puzzle Cell. 133: 958-961. PMID 18555773 DOI: 10.1016/J.Cell.2008.05.027  0.293
2021 Warren A, Chen Y, Jones A, Shibue T, Hahn WC, Boehm JS, Vazquez F, Tsherniak A, McFarland JM. Global computational alignment of tumor and cell line transcriptional profiles. Nature Communications. 12: 22. PMID 33397959 DOI: 10.1038/s41467-020-20294-x  0.293
2019 Wang X, Wang S, Troisi EC, Howard TP, Haswell JR, Wolf BK, Hawk WH, Ramos P, Oberlick EM, Tzvetkov EP, Ross A, Vazquez F, Hahn WC, Park PJ, Roberts CWM. Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors. Nature Communications. 10: 4445. PMID 31558726 DOI: 10.1038/S41467-019-12524-8  0.29
2010 Matulonis U, Hirsch M, Liu J, Hahn W. 35 Mutational analysis of epithelial ovarian cancer using OncoMap European Journal of Cancer Supplements. 8: 21. DOI: 10.1016/S1359-6349(10)71740-7  0.29
2005 Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America. 102: 8222-7. PMID 15928077 DOI: 10.1073/Pnas.0503095102  0.289
2014 Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Liu H, Yoda A, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, ... ... Hahn WC, et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nature Genetics. 46: 618-23. PMID 24747640 DOI: 10.1038/Ng.2949  0.289
2012 Kijima N, Hosen N, Kagawa N, Hashimoto N, Chiba Y, Kinoshita M, Sugiyama H, Yoshimine T, Kim YZ, Kim KH, Lee EH, Hu B, Sim H, Mohan N, Agudelo-Garcia P, ... ... Hahn WC, et al. LAB-CELL BIOLOGY AND SIGNALING Neuro-Oncology. 14: vi7-vi20. DOI: 10.1093/Neuonc/Nos220  0.285
2022 Collins NB, Al Abosy R, Miller BC, Bi K, Zhao Q, Quigley M, Ishizuka JJ, Yates KB, Pope HW, Manguso RT, Shrestha Y, Wadsworth M, Hughes T, Shalek AK, Boehm JS, ... Hahn WC, et al. PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment. Journal For Immunotherapy of Cancer. 10. PMID 35264433 DOI: 10.1136/jitc-2021-003402  0.285
2012 Eck MJ, Hahn WC. EGFR in limbo. Cell. 149: 735-7. PMID 22579278 DOI: 10.1016/J.Cell.2012.04.015  0.282
1993 Bierer BE, Hahn WC. T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2. Seminars in Immunology. 5: 249-61. PMID 7693022 DOI: 10.1006/Smim.1993.1029  0.281
2004 Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, Hahn WC, Hodes RJ. Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Molecular and Cellular Biology. 24: 7024-31. PMID 15282303 DOI: 10.1128/Mcb.24.16.7024-7031.2004  0.281
2005 Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM. The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors Developmental Cell. 9: 327-338. PMID 16139224 DOI: 10.1016/J.Devcel.2005.07.014  0.28
2007 Trent J, Carpten J, Reich M, Liefeld T, Keats J, Mousses S, Hahn W, Trudel S, Siegel D, Rajkumar SV, Alsina M, Richardson P, Anderson K, Auclair D, Perkins LM, et al. The Multiple Myeloma Research Consortium Genomics Initiative. Blood. 110: 2498-2498. DOI: 10.1182/Blood.V110.11.2498.2498  0.28
2016 Bellmunt J, Zhou CW, Mullane SA, Werner L, Taplin ME, Fay AP, Choueiri TK, Orsola A, Takeda DY, Hahn WC, Kim J, Sonpavde G, Bowden M. Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy. British Journal of Cancer. 115: 12-19. PMID 27351382 DOI: 10.1038/Bjc.2016.146  0.28
2014 Riester M, Werner L, Bellmunt J, Selvarajah S, Guancial EA, Weir BA, Stack EC, Park RS, O'Brien R, Schutz FA, Choueiri TK, Signoretti S, Lloreta J, Marchionni L, Gallardo E, ... ... Hahn WC, et al. Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1873-83. PMID 24486590 DOI: 10.1158/1078-0432.Ccr-13-0759  0.277
2003 Chen W, Hahn WC. SV40 early region oncoproteins and human cell transformation. Histology and Histopathology. 18: 541-50. PMID 12647805 DOI: 10.14670/HH-18.541  0.276
2015 White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM. Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. Journal of Virology. 89: 2857-65. PMID 25540383 DOI: 10.1128/Jvi.03282-14  0.275
2006 Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum Journal of Biological Chemistry. 281: 23003-23012. PMID 16717086 DOI: 10.1074/Jbc.M602648200  0.275
2021 Baca SC, Takeda DY, Seo JH, Hwang J, Ku SY, Arafeh R, Arnoff T, Agarwal S, Bell C, O'Connor E, Qiu X, Alaiwi SA, Corona RI, Fonseca MAS, Giambartolomei C, ... ... Hahn WC, et al. Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer. Nature Communications. 12: 1979. PMID 33785741 DOI: 10.1038/s41467-021-22139-7  0.274
2017 Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nature Communications. 8: 15110. PMID 28447610 DOI: 10.1038/Ncomms15110  0.274
2006 Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, ... Hahn WC, et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 127: 759-73. PMID 17110335 DOI: 10.1016/J.Cell.2006.10.035  0.274
2014 Lin L, Vega M, Jones RT, Ziaugra L, Dolcen DN, Sunkavalli A, Schubert L, Lepine JR, Thorner AR, Ducar MD, Hahn WC, Meyerson ML, MacConaill LE, Hummelen PV. Abstract 4286: Improved FFPE DNA extraction for next generation sequencing using adaptive focused acoustics technology Cancer Research. 74: 4286-4286. DOI: 10.1158/1538-7445.Am2014-4286  0.273
2009 Rosenbluh J, Nijhawan D, Hahn WC. Regulating TERT: location, location, location. Cell Cycle (Georgetown, Tex.). 8: 3257. PMID 19823010 DOI: 10.4161/Cc.8.20.10037  0.272
2011 Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, et al. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 82: 17-33. PMID 21108995 DOI: 10.1016/J.Fitote.2010.11.017  0.272
2013 Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, et al. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Reports. 3: 747-58. PMID 23453972 DOI: 10.1016/J.Celrep.2013.01.033  0.272
2018 Ng K, Hendifar A, Starodub A, Chaves J, Yang Y, Koh B, Barbie D, Hahn WC, Fuchs CS. Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. Investigational New Drugs. PMID 30105668 DOI: 10.1007/S10637-018-0650-5  0.271
2015 Chen L, Lai Y, Zhu X, Ma L, Bai Q, Vazquez I, Xiao Y, Liu C, Li D, Gao C, He Z, Zeng X, Xing X, Zhang Z, Li J, ... ... Hahn WC, et al. The role of specific PP2A complexes in the dephosphorylation of γH2AX. Journal of Cell Science. 128: 421. PMID 25236601 DOI: 10.1242/Jcs.147223  0.271
2011 Rosenbluh J, Nijhawan D, Chen Z, Wong KK, Masutomi K, Hahn WC. RMRP is a non-coding RNA essential for early murine development. Plos One. 6: e26270. PMID 22039455 DOI: 10.1371/Journal.Pone.0026270  0.27
2013 Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, ... ... Hahn WC, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 498: 246-50. PMID 23728299 DOI: 10.1038/Nature12147  0.27
1993 Hahn WC, Bierer BE. Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation. The Journal of Experimental Medicine. 178: 1831-6. PMID 7901319 DOI: 10.1084/Jem.178.5.1831  0.267
2021 Elmarakeby HA, Hwang J, Arafeh R, Crowdis J, Gang S, Liu D, AlDubayan SH, Salari K, Kregel S, Richter C, Arnoff TE, Park J, Hahn WC, M Van Allen E. Biologically informed deep neural network for prostate cancer discovery. Nature. PMID 34552244 DOI: 10.1038/s41586-021-03922-4  0.267
2009 Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA Nature. 461: 230-235. PMID 19701182 DOI: 10.1038/Nature08283  0.26
2003 Hahn WC. Immortalization and transformation of human cells. Molecules and Cells. 13: 351-61. PMID 12132573  0.259
2004 Khurts S, Masutomi K, Delgermaa L, Arai K, Oishi N, Mizuno H, Hayashi N, Hahn WC, Murakami S. Nucleolin interacts with telomerase Journal of Biological Chemistry. 279: 51508-51515. PMID 15371412 DOI: 10.1074/Jbc.M407643200  0.259
2024 Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, MacConaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. Author Correction: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB. Nature Medicine. PMID 38383797 DOI: 10.1038/s41591-024-02866-2  0.259
1985 Carlson J, Rushlow K, Maxwell I, Maxwell F, Winston S, Hahn W. Cloning and sequence of DNA encoding structural proteins of the autonomous parvovirus feline panleukopenia virus. Journal of Virology. 55: 574-82. PMID 2991581 DOI: 10.1128/Jvi.55.3.574-582.1985  0.254
2022 Tang S, Sethunath V, Metaferia NY, Nogueira MF, Gallant DS, Garner ER, Lairson LA, Penney CM, Li J, Gelbard MK, Alaiwi SA, Seo JH, Hwang JH, Strathdee CA, Baca SC, ... ... Hahn WC, et al. A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Reports. 38: 110417. PMID 35196489 DOI: 10.1016/j.celrep.2022.110417  0.253
1995 Liu SJ, Hahn WC, Bierer BE, Golan DE. Intracellular mediators regulate CD2 lateral diffusion and cytoplasmic Ca2+ mobilization upon CD2-mediated T cell activation. Biophysical Journal. 68: 459-70. PMID 7696499 DOI: 10.1016/S0006-3495(95)80207-9  0.251
2015 Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM. Correction for hwang et Al., polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 89: 6971. PMID 26041839 DOI: 10.1128/Jvi.00952-15  0.251
2022 Pan J, Kwon JJ, Talamas JA, Borah AA, Vazquez F, Boehm JS, Tsherniak A, Zitnik M, McFarland JM, Hahn WC. Sparse dictionary learning recovers pleiotropy from human cell fitness screens. Cell Systems. PMID 35085500 DOI: 10.1016/j.cels.2021.12.005  0.25
2004 Hahn WC. Experimental models of human cancer. Cell Cycle (Georgetown, Tex.). 3: 604-5. PMID 15044854 DOI: 10.4161/cc.3.5.836  0.25
1992 Rosenstein Y, Park JK, Hahn WC, Rosen FS, Bierer BE, Burakoff SJ. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature. 354: 233-5. PMID 1683685 DOI: 10.1038/354233A0  0.25
2014 Kim Y, Lee S, Chun S, Kim K, Kim Y, Nam J, Hummelen P, MacConaill L, Hahn W, Jang S. Analysis and comparison of somatic mutations between primary and recurrent ovarian carcinomas: A study in serial samples Gynecologic Oncology. 133: 187. DOI: 10.1016/J.Ygyno.2014.03.497  0.249
2014 Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM. PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Molecular Cell. 54: 932-45. PMID 24857551 DOI: 10.1016/J.Molcel.2014.04.023  0.245
2021 Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Brüggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, ... ... Hahn WC, et al. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Reports. 34: 108532. PMID 33406420 DOI: 10.1016/j.celrep.2020.108532  0.243
2022 Hwang JH, Arafeh R, Seo JH, Baca SC, Ludwig M, Arnoff TE, Sawyer L, Richter C, Tape S, Bergom HE, McSweeney S, Rennhack JP, Klingenberg SA, Cheung ATM, Kwon J, ... ... Hahn WC, et al. CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor targeting therapies. Elife. 11. PMID 35550030 DOI: 10.7554/eLife.73223  0.241
2007 Cho US, Morrone S, Sablina AA, Arroyo JD, Hahn WC, Xu W. Structural basis of PP2A inhibition by small t antigen. Plos Biology. 5: e202. PMID 17608567 DOI: 10.1371/Journal.Pbio.0050202  0.241
1992 Hahn WC, Rosenstein Y, Calvo V, Burakoff SJ, Bierer BE. A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen. Proceedings of the National Academy of Sciences of the United States of America. 89: 7179-83. PMID 1353888 DOI: 10.1073/Pnas.89.15.7179  0.24
2015 Shrestha Y, Hahn WC. Regulatory signaling networks in cell transformation and cancer Systems Biology of Cancer. 169-182. DOI: 10.1017/9780511979811.012  0.239
1993 Collins TL, Hahn WC, Bierer BE, Burakoff SJ. CD4, CD8 and CD2 in T cell adhesion and signaling Current Topics in Microbiology and Immunology. 184: 223-233. PMID 7906216 DOI: 10.1007/978-3-642-78253-4_18  0.239
2017 Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang H, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, ... ... Hahn WC, et al. Author response: Synergistic interactions with PI3K inhibition that induce apoptosis Elife. DOI: 10.7554/Elife.24523.023  0.235
2021 Dempster JM, Boyle I, Vazquez F, Root DE, Boehm JS, Hahn WC, Tsherniak A, McFarland JM. Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects. Genome Biology. 22: 343. PMID 34930405 DOI: 10.1186/s13059-021-02540-7  0.234
2017 Han GC, Hwang J, Wankowicz SAM, Zhang Z, Liu D, Cibulskis C, Gaviola GC, Ghazikhanian V, McKay RR, Bubley GJ, Carter SL, Balk SP, Hahn WC, Taplin ME, Van Allen EM. Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer. Jco Precision Oncology. 1. PMID 32913968 DOI: 10.1200/PO.17.00140  0.232
2015 Huang X, Jayabalan D, Di Liberto M, Chen Z, Schinzel AC, Ely S, Rossi AC, Pearse RN, Aneja E, Coleman M, Lane JM, Hahn WC, Mark TM, Niesvizky R, Chen-Kiang S. Inhibition of CDK4/CDK6 Sensitizes Myeloma to IMiD By Reducing the MEIS2 to Cereblon Ratio That Accelerates IKZF1 and IKZF3 Degradation Blood. 126: 500-500. DOI: 10.1182/Blood.V126.23.500.500  0.23
2023 Mead BE, Kummerlowe C, Liu N, Kattan WE, Cheng T, Cheah JH, Soule CK, Peters J, Lowder KE, Blainey PC, Hahn WC, Cleary B, Bryson B, Winter PS, Raghavan S, et al. Compressed phenotypic screens for complex multicellular models and high-content assays. Biorxiv : the Preprint Server For Biology. PMID 36747859 DOI: 10.1101/2023.01.23.525189  0.228
2013 Hettmer S, Schinzel A, Hahn WC, Wagers A. Abstract 3812: Target identification in rhabdomyosarcomas induced in mouse skeletal muscle. Cancer Research. 73: 3812-3812. DOI: 10.1158/1538-7445.Am2013-3812  0.227
2007 Park Y, Downing SR, Kim D, Hahn WC, Li C, Kantoff PW, Wei LJ. Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: Application to mass spec data Bioinformatics. 23: 1451-1458. PMID 17459967 DOI: 10.1093/Bioinformatics/Btm130  0.227
2017 Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nature Communications. 8: 15918. PMID 28607496 DOI: 10.1038/Ncomms15918  0.225
2013 Sodavarapu S, Reddy S, Imbertson E, Grotts J, Egan JV, Hahn W, Petrini JL. Tu1083 Do Patients Having Unsedated Colonoscopy ReQuest Sedation for Subsequent Colonoscopy? A Retrospective Study Gastroenterology. 144: S-756. DOI: 10.1016/S0016-5085(13)62799-7  0.223
1997 Hahn WC, Jones D, Leavitt P, Garber J, Stone R, Skarin AT. Diagnosis in Oncology. Leukemia cutis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 15: 2170-1. PMID 9164232 DOI: 10.1200/Jco.1997.15.5.2170  0.219
2019 de Matos Simoes R, Shirasaki R, Tang H, Sheffer M, Dashevsky O, Downey-Kopyscinski S, Dhimolea E, Bariteau M, Licht J, Glassner BJ, Levy J, Auclair D, Vazquez F, Tsherniak A, Hahn W, et al. CRISPR-based functional genomics landscape of genes recurrently mutated in MM Clinical Lymphoma Myeloma and Leukemia. 19: e77-e78. DOI: 10.1016/J.Clml.2019.09.123  0.214
2013 Hahn WC. The perfect storm: challenges and opportunities for translational medicine. The Journal of Clinical Investigation. 123: 4963-6. PMID 24177467 DOI: 10.1172/Jci73221  0.213
2013 Tu D, Zhu Z, Zhou AY, Yun C, Lee K, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, et al. Structure of Tank-Binding Kinase 1 Cell Reports. DOI: 10.2210/Pdb4Im0/Pdb  0.209
1992 Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science (New York, N.Y.). 256: 1805-7. PMID 1377404 DOI: 10.1126/Science.1377404  0.208
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