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Year Citation  Score
2019 Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, ... ... Hahn WC, et al. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Reports. 29: 118-134.e8. PMID 31577942 DOI: 10.1016/j.celrep.2019.08.090  0.52
2019 Bandopadhayay P, Piccioni F, O'Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, ... ... Hahn WC, et al. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nature Communications. 10: 2400. PMID 31160565 DOI: 10.1038/s41467-019-10307-9  0.4
2018 Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, ... ... Hahn WC, et al. Mutational processes shape the landscape of TP53 mutations in human cancer. Nature Genetics. PMID 30224644 DOI: 10.1038/s41588-018-0204-y  0.52
2018 Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer. Molecular Cancer Therapeutics. PMID 30097486 DOI: 10.1158/1535-7163.MCT-17-1090  0.52
2018 Li J, Choi PS, Chaffer CL, Labella K, Hwang JH, Giacomelli AO, Kim JW, Ilic N, Doench JG, Ly SH, Dai C, Hagel K, Hong AL, Gjoerup O, Goel S, ... ... Hahn WC, et al. An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer. Elife. 7. PMID 30059005 DOI: 10.7554/eLife.37184  0.36
2018 Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, ... ... Hahn WC, et al. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29961768 DOI: 10.1038/s41436-018-0009-5  0.52
2018 Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, ... ... Hahn WC, et al. Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine. Cancer Discovery. PMID 29903880 DOI: 10.1158/2159-8290.CD-18-0275  0.52
2017 Bullman S, Pedamallu CS, Sicinska E, Clancy TE, Zhang X, Cai D, Neuberg D, Huang K, Guevara F, Nelson T, Chipashvili O, Hagan T, Walker M, Ramachandran A, Diosdado B, ... ... Hahn WC, et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science (New York, N.Y.). PMID 29170280 DOI: 10.1126/science.aal5240  0.52
2017 Aguirre AJ, Hahn WC. Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers. Cold Spring Harbor Perspectives in Medicine. PMID 29101114 DOI: 10.1101/cshperspect.a031518  0.52
2017 Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, ... ... Hahn WC, et al. Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6. PMID 29087937 DOI: 10.7554/eLife.33173  0.52
2017 Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, ... ... Hahn WC, et al. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. Cell Systems. 5: 105-118.e9. PMID 28837809 DOI: 10.1016/j.cels.2017.08.002  0.52
2017 Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, ... ... Hahn WC, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/nature23007  0.52
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, ... ... Hahn WC, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/pnas.1617922114  0.52
2017 Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, ... ... Hahn WC, et al. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 6. PMID 28145866 DOI: 10.7554/eLife.18970  0.52
2016 Howard TP, Vazquez F, Tsherniak A, Hong AL, Rinne M, Aguirre AJ, Boehm JS, Hahn WC. Functional Genomic Characterization of Cancer Genomes. Cold Spring Harbor Symposia On Quantitative Biology. PMID 27815544 DOI: 10.1101/sqb.2016.81.031070  0.52
2016 Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, ... Hahn WC, et al. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Cell Systems. 3: 302-316.e4. PMID 27684187 DOI: 10.1016/j.cels.2016.09.001  0.36
2016 Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro-Oncology. PMID 27402815 DOI: 10.1093/neuonc/now139  0.36
2016 Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, ... ... Hahn WC, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nature Communications. 7: 11987. PMID 27329820 DOI: 10.1038/ncomms11987  0.36
2016 Aguirre AJ, Meyers RM, Weir BA, Vazquez F, Zhang CZ, Ben-David U, Cook A, Ha G, Harrington WF, Doshi MB, Kost-Alimova M, Gill S, Xu H, Ali LD, Jiang G, ... ... Hahn WC, et al. Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting. Cancer Discovery. PMID 27260156 DOI: 10.1158/2159-8290.CD-16-0154  0.36
2016 Kim E, Ilic N, Shrestha Y, Zou L, Kamburov A, Zhu C, Yang X, Lubonja R, Tran N, Nguyen C, Lawrence MS, Piccioni F, Bagul M, Doench JG, Chouinard CR, ... ... Hahn WC, et al. Systematic functional interrogation of rare cancer variants identifies oncogenic alleles. Cancer Discovery. PMID 27147599 DOI: 10.1158/2159-8290.CD-16-0160  0.36
2016 Kim JW, Botvinnik OB, Abudayyeh O, Birger C, Rosenbluh J, Shrestha Y, Abazeed ME, Hammerman PS, DiCara D, Konieczkowski DJ, Johannessen CM, Liberzon A, Alizad-Rahvar AR, Alexe G, Aguirre A, ... ... Hahn WC, et al. Characterizing genomic alterations in cancer by complementary functional associations. Nature Biotechnology. PMID 27088724 DOI: 10.1038/nbt.3527  0.36
2015 Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, ... ... Hahn WC, et al. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discovery. PMID 26410082 DOI: 10.1158/2159-8290.CD-15-0369  0.36
2015 Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, ... ... Hahn WC, et al. Rapid Intraoperative Molecular Characterization of Glioma. Jama Oncology. PMID 26181761 DOI: 10.1001/jamaoncol.2015.0917  0.36
2015 Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM. Correction for hwang et Al., polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 89: 6971. PMID 26041839 DOI: 10.1128/JVI.00952-15  0.36
2015 White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM. Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. Journal of Virology. 89: 2857-65. PMID 25540383 DOI: 10.1128/JVI.03282-14  0.36
2015 Abo RP, Ducar M, Garcia EP, Thorner AR, Rojas-Rudilla V, Lin L, Sholl LM, Hahn WC, Meyerson M, Lindeman NI, Van Hummelen P, MacConaill LE. BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers. Nucleic Acids Research. 43: e19. PMID 25428359 DOI: 10.1093/nar/gku1211  0.36
2015 Luo LY, Kim E, Cheung HW, Weir BA, Dunn GP, Shen RR, Hahn WC. The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. Molecular Cancer Research : McR. 13: 502-9. PMID 25368431 DOI: 10.1158/1541-7786.MCR-14-0407  0.36
2015 Moody SE, Schinzel AC, Singh S, Izzo F, Strickland MR, Luo L, Thomas SR, Boehm JS, Kim SY, Wang ZC, Hahn WC. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene. 34: 2061-71. PMID 24909179 DOI: 10.1038/onc.2014.153  0.36
2014 Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, ... ... Hahn WC, et al. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Scientific Data. 1: 140035. PMID 25984343 DOI: 10.1038/sdata.2014.35  0.36
2014 MacConaill LE, Garcia E, Shivdasani P, Ducar M, Adusumilli R, Breneiser M, Byrne M, Chung L, Conneely J, Crosby L, Garraway LA, Gong X, Hahn WC, Hatton C, Kantoff PW, et al. Prospective enterprise-level molecular genotyping of a cohort of cancer patients. The Journal of Molecular Diagnostics : Jmd. 16: 660-72. PMID 25157968 DOI: 10.1016/j.jmoldx.2014.06.004  0.36
2014 Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Hahn WC, Schaffhausen BS, Roberts TM. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. Journal of Virology. 88: 12055-64. PMID 25122798 DOI: 10.1128/JVI.01399-14  0.36
2014 Sevenich L, Bowman RL, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E, Brastianos PK, Hahn WC, Holsinger LJ, Massagué J, Leslie CS, Joyce JA. Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nature Cell Biology. 16: 876-88. PMID 25086747 DOI: 10.1038/ncb3011  0.36
2014 Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158: 171-84. PMID 24954536 DOI: 10.1016/j.cell.2014.06.004  0.36
2014 Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM. PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Molecular Cell. 54: 932-45. PMID 24857551 DOI: 10.1016/j.molcel.2014.04.023  0.4
2014 Konieczkowski DJ, Johannessen CM, Abudayyeh O, Kim JW, Cooper ZA, Piris A, Frederick DT, Barzily-Rokni M, Straussman R, Haq R, Fisher DE, Mesirov JP, Hahn WC, Flaherty KT, Wargo JA, et al. A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors. Cancer Discovery. 4: 816-27. PMID 24771846 DOI: 10.1158/2159-8290.CD-13-0424  0.36
2014 Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Liu H, Yoda A, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, ... ... Hahn WC, et al. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nature Genetics. 46: 618-23. PMID 24747640 DOI: 10.1038/ng.2949  0.36
2014 Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW. ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nature Medicine. 20: 251-4. PMID 24562383 DOI: 10.1038/nm.3480  0.52
2014 Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, ... ... Hahn WC, et al. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discovery. 4: 452-65. PMID 24444711 DOI: 10.1158/2159-8290.CD-13-0646  0.36
2014 Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, ... ... Hahn WC, et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell Reports. 6: 313-24. PMID 24440720 DOI: 10.1016/j.celrep.2013.12.032  0.36
2014 Brastianos PK, Taylor-Weiner A, Manley PE, Jones RT, Dias-Santagata D, Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L, Sunkavalli A, Shillingford N, Calicchio ML, Lidov HG, Taha H, ... ... Hahn WC, et al. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nature Genetics. 46: 161-5. PMID 24413733 DOI: 10.1038/ng.2868  0.36
2014 Dunn GP, Cheung HW, Agarwalla PK, Thomas S, Zektser Y, Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L, Getz G, Liu JF, Hirsch M, Vazquez F, Root DE, ... ... Hahn WC, et al. In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proceedings of the National Academy of Sciences of the United States of America. 111: 1102-7. PMID 24385586 DOI: 10.1073/pnas.1311909111  0.36
2014 Rosenbluh J, Wang X, Hahn WC. Genomic insights into WNT/β-catenin signaling. Trends in Pharmacological Sciences. 35: 103-9. PMID 24365576 DOI: 10.1016/j.tips.2013.11.007  0.36
2013 Etemadmoghadam D, Weir BA, Au-Yeung G, Alsop K, Mitchell G, George J, Davis S, D'Andrea AD, Simpson K, Hahn WC, Bowtell DD. Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proceedings of the National Academy of Sciences of the United States of America. 110: 19489-94. PMID 24218601 DOI: 10.1073/pnas.1314302110  0.36
2013 Hahn WC. The perfect storm: challenges and opportunities for translational medicine. The Journal of Clinical Investigation. 123: 4963-6. PMID 24177467 DOI: 10.1172/JCI73221  0.36
2013 Hanna MC, Go C, Roden C, Jones RT, Pochanard P, Javed AY, Javed A, Mondal C, Palescandolo E, Van Hummelen P, Hatton C, Bass AJ, Chun SM, Na DC, Kim TI, ... ... Hahn WC, et al. Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. Plos One. 8: e74950. PMID 24066160 DOI: 10.1371/journal.pone.0074950  0.36
2013 Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 153: 1327-39. PMID 23746844 DOI: 10.1016/j.cell.2013.04.048  0.4
2013 Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, ... ... Hahn WC, et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 498: 246-50. PMID 23728299 DOI: 10.1038/nature12147  0.4
2013 Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC. IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Reports. 3: 724-33. PMID 23453969 DOI: 10.1016/j.celrep.2013.01.031  0.36
2013 Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, ... Hahn WC, et al. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nature Genetics. 45: 285-9. PMID 23334667 DOI: 10.1038/ng.2526  0.36
2012 Quayle SN, Chheda MG, Shukla SA, Wiedemeyer R, Tamayo P, Dewan RW, Zhuang L, Huang-Hobbs E, Haidar S, Xiao Y, Ligon KL, Hahn WC, Chin L. Integrative functional genomics identifies RINT1 as a novel GBM oncogene. Neuro-Oncology. 14: 1325-31. PMID 23074196 DOI: 10.1093/neuonc/nos246  0.36
2012 Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, ... ... Hahn WC, et al. Cancer vulnerabilities unveiled by genomic loss. Cell. 150: 842-54. PMID 22901813 DOI: 10.1016/j.cell.2012.07.023  0.36
2012 Ren Y, Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir BA, Boehm JS, Tamayo P, Karst AM, Liu JF, Hirsch MS, Mesirov JP, Drapkin R, Root DE, Lo J, ... ... Hahn WC, et al. Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Science Translational Medicine. 4: 147ra112. PMID 22896676 DOI: 10.1126/scitranslmed.3003778  0.36
2012 Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, ... ... Hahn WC, et al. Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. Plos Genetics. 8: e1002772. PMID 22829774 DOI: 10.1371/journal.pgen.1002772  0.4
2012 Bellucci R, Nguyen HN, Martin A, Heinrichs S, Schinzel AC, Hahn WC, Ritz J. Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. The Journal of Clinical Investigation. 122: 2369-83. PMID 22684105 DOI: 10.1172/JCI58457  0.4
2012 Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM. MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma. Science Signaling. 5: rs4. PMID 22589389 DOI: 10.1126/scisignal.2002612  0.4
2012 Banerji V, Frumm SM, Ross KN, Li LS, Schinzel AC, Hahn CK, Kakoza RM, Chow KT, Ross L, Alexe G, Tolliday N, Inguilizian H, Galinsky I, Stone RM, DeAngelo DJ, ... ... Hahn WC, et al. The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. The Journal of Clinical Investigation. 122: 935-47. PMID 22326953 DOI: 10.1172/JCI46465  0.36
2012 Shrestha Y, Schafer EJ, Boehm JS, Thomas SR, He F, Du J, Wang S, Barretina J, Weir BA, Zhao JJ, Polyak K, Golub TR, Beroukhim R, Hahn WC. PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling. Oncogene. 31: 3397-408. PMID 22105362 DOI: 10.1038/onc.2011.515  0.36
2011 Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, ... ... Hahn WC, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/ng.936  0.36
2011 Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, ... ... Hahn WC, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 146: 904-17. PMID 21889194 DOI: 10.1016/j.cell.2011.08.017  0.4
2011 Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, ... ... Hahn WC, et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 108: 12372-7. PMID 21746896 DOI: 10.1073/pnas.1109363108  0.36
2011 Lund P, Kotova I, Kedinger V, Khanwalkar H, Voltz E, Hahn WC, Gronemeyer H. Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine. Molecular Cancer Therapeutics. 10: 1611-23. PMID 21697397 DOI: 10.1158/1535-7163.MCT-11-0140  0.36
2011 Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, ... ... Hahn WC, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. The Journal of Clinical Investigation. 121: 2723-35. PMID 21633165 DOI: 10.1172/JCI44745  0.36
2011 Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M, Garraway LA. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3085-96. PMID 21383288 DOI: 10.1200/JCO.2010.33.2312  0.36
2011 Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, dal Zuffo R, Matti V, d'Ario G, Montani E, Mercurio C, Hahn WC, Gorgoulis V, Minucci S, d'Adda di Fagagna F. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature Cell Biology. 13: 292-302. PMID 21336312 DOI: 10.1038/ncb2170  0.36
2010 Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, ... ... Hahn WC, et al. Therapeutic implications of GIPC1 silencing in cancer. Plos One. 5: e15581. PMID 21209904 DOI: 10.1371/journal.pone.0015581  0.36
2010 Sablina AA, Hector M, Colpaert N, Hahn WC. Identification of PP2A complexes and pathways involved in cell transformation. Cancer Research. 70: 10474-84. PMID 21159657 DOI: 10.1158/0008-5472.CAN-10-2855  0.36
2010 Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, ... ... Hahn WC, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 468: 968-72. PMID 21107320 DOI: 10.1038/nature09627  0.36
2010 Pomerantz MM, Shrestha Y, Flavin RJ, Regan MM, Penney KL, Mucci LA, Stampfer MJ, Hunter DJ, Chanock SJ, Schafer EJ, Chan JA, Tabernero J, Baselga J, Richardson AL, Loda M, ... ... Hahn WC, et al. Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis. Plos Genetics. 6: e1001204. PMID 21085629 DOI: 10.1371/journal.pgen.1001204  0.4
2010 Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro SB, Mollah SA, Shabanowitz J, Hunt DF, Xenarios I, Hahn WC, Conaway M, Carey MF, Gioeli D. CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation. Molecular Endocrinology (Baltimore, Md.). 24: 2267-80. PMID 20980437 DOI: 10.1210/me.2010-0238  0.36
2010 Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. The Journal of Clinical Investigation. 120: 3940-52. PMID 20972333 DOI: 10.1172/JCI44165  0.36
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, ... ... Hahn WC, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/nbt0910-904  0.4
2010 Wiedemeyer WR, Dunn IF, Quayle SN, Zhang J, Chheda MG, Dunn GP, Zhuang L, Rosenbluh J, Chen S, Xiao Y, Shapiro GI, Hahn WC, Chin L. Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Proceedings of the National Academy of Sciences of the United States of America. 107: 11501-6. PMID 20534551 DOI: 10.1073/pnas.1001613107  0.36
2010 Moody SE, Boehm JS, Barbie DA, Hahn WC. Functional genomics and cancer drug target discovery. Current Opinion in Molecular Therapeutics. 12: 284-93. PMID 20521217  0.36
2010 Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, ... ... Hahn WC, et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 17: 497-509. PMID 20478531 DOI: 10.1016/j.ccr.2010.03.020  0.36
2010 Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Schoeberl B, ... ... Hahn WC, et al. An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell. 17: 298-310. PMID 20227043 DOI: 10.1016/j.ccr.2009.12.047  0.36
2010 Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. An oncogenic role for ETV1 in melanoma. Cancer Research. 70: 2075-84. PMID 20160028 DOI: 10.1158/0008-5472.CAN-09-3092  0.36
2010 Min J, Zaslavsky A, Fedele G, McLaughlin SK, Reczek EE, De Raedt T, Guney I, Strochlic DE, Macconaill LE, Beroukhim R, Bronson RT, Ryeom S, Hahn WC, Loda M, Cichowski K. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB. Nature Medicine. 16: 286-94. PMID 20154697 DOI: 10.1038/nm.2100  0.36
2010 Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Molecular Biology of the Cell. 21: 1140-52. PMID 20110348 DOI: 10.1091/mbc.E09-09-0795  0.4
2010 Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, Giovannucci EL, Hahn WC, Fuchs CS, Ogino S. CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. International Journal of Cancer. Journal International Du Cancer. 126: 2863-73. PMID 19790197 DOI: 10.1002/ijc.24908  0.36
2010 Sheng Q, Liu X, Fleming E, Yuan K, Piao H, Chen J, Moustafa Z, Thomas RK, Greulich H, Schinzel A, Zaghlul S, Batt D, Ettenberg S, Meyerson M, Kung BSAL, ... Hahn WC, et al. An Activated ErbB3/NRG1 Autocrine Loop Supports In Vivo Proliferation in Ovarian Cancer Cells (DOI:10.1016/j.ccr.2009.12.047) Cancer Cell. 17: 412. DOI: 10.1016/j.ccr.2010.03.014  0.36
2009 MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, ... ... Hahn WC, et al. Profiling critical cancer gene mutations in clinical tumor samples. Plos One. 4: e7887. PMID 19924296 DOI: 10.1371/journal.pone.0007887  0.36
2009 Firestein R, Hahn WC. Revving the Throttle on an oncogene: CDK8 takes the driver seat. Cancer Research. 69: 7899-901. PMID 19808961 DOI: 10.1158/0008-5472.CAN-09-1704  0.36
2009 Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, ... ... Hahn WC, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genetics. 41: 1238-42. PMID 19801978 DOI: 10.1038/ng.465  0.36
2009 Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA Nature. 461: 230-235. PMID 19701182 DOI: 10.1038/nature08283  0.36
2009 Cheng H, Liu P, Wang ZC, Zou L, Santiago S, Garbitt V, Gjoerup OV, Iglehart JD, Miron A, Richardson AL, Hahn WC, Zhao JJ. SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. Science Signaling. 2: ra35. PMID 19622832 DOI: 10.1126/scisignal.2000369  0.36
2009 Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, ... ... Hahn WC, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 16: 21-32. PMID 19573809 DOI: 10.1016/j.ccr.2009.04.012  0.36
2009 Loda M, Migita T, Ruiz S, Fornari A, Fiorentino M, Priolo C, Zadra G, Inazuka F, Grisanzio C, Palescandolo E, Shin E, Fiore C, Xie W, Kung AL, Febbo PG, ... ... Hahn WC, et al. Fatty acid synthase: A metabolic enzyme and candidate oncogene in prostate cancer Journal of the National Cancer Institute. 101: 519-532. PMID 19318631 DOI: 10.1093/jnci/djp030  0.36
2009 Rosenberg JE, Hahn WC. Bladder cancer: Modeling and translation Genes and Development. 23: 655-659. PMID 19299556 DOI: 10.1101/gad.1789109  0.36
2009 Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J. PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma Cancer Research. 69: 2870-2877. PMID 19293187 DOI: 10.1158/0008-5472.CAN-08-2760  0.36
2009 Downward J, Hahn WC. Genetic and cellular mechanisms of oncogenesis Current Opinion in Genetics and Development. 19: 1-3. PMID 19208465 DOI: 10.1016/j.gde.2009.01.001  0.36
2008 Jeong JH, Wang Z, Guimaraes AS, Ouyang X, Figueiredo JL, Ding Z, Jiang S, Guney I, Kang GH, Shin E, Hahn WC, Loda MF, Abate-Shen C, Weissleder R, Chin L. BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. Plos One. 3: e3949. PMID 19079609 DOI: 10.1371/journal.pone.0003949  0.36
2008 Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, ... ... Hahn WC, et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 19372-7. PMID 19050074 DOI: 10.1073/pnas.0809966105  0.52
2008 Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek WK, Wang S, Ellwood-Yen K, Wu H, ... ... Hahn WC, et al. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell. 14: 146-55. PMID 18691549 DOI: 10.1016/j.ccr.2008.06.002  0.36
2008 Cichowski K, Hahn WC. Unexpected Pieces to the Senescence Puzzle Cell. 133: 958-961. PMID 18555773 DOI: 10.1016/j.cell.2008.05.027  0.36
2008 Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, et al. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 13: 394-406. PMID 18455123 DOI: 10.1016/j.ccr.2008.03.007  0.36
2008 Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, et al. Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell. 13: 355-64. PMID 18394558 DOI: 10.1016/j.ccr.2008.02.010  0.36
2008 Pienta KJ, Abate-Shen C, Agus DB, Attar RM, Chung LW, Greenberg NM, Hahn WC, Isaacs JT, Navone NM, Peehl DM, Simons JW, Solit DB, Soule HR, VanDyke TA, Weber MJ, et al. The current state of preclinical prostate cancer animal models. The Prostate. 68: 629-39. PMID 18213636 DOI: 10.1002/pros.20726  0.4
2007 Sablina AA, Hahn WC. The role of PP2A A subunits in tumor suppression Cell Adhesion & Migration. 1: 140-141. PMID 19262135  0.4
2007 Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & Development. 21: 2683-710. PMID 17974913 DOI: 10.1101/gad.1596707  0.36
2007 Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, ... ... Hahn WC, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 129: 1065-79. PMID 17574021 DOI: 10.1016/j.cell.2007.03.052  0.36
2007 Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC. The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase Cell. 129: 969-982. PMID 17540176 DOI: 10.1016/j.cell.2007.03.047  0.36
2007 Nieto M, Finn S, Loda M, Hahn WC. Prostate cancer: Re-focusing on androgen receptor signaling International Journal of Biochemistry and Cell Biology. 39: 1562-1568. PMID 17321194 DOI: 10.1016/j.biocel.2007.01.005  0.36
2006 Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods. 3: 715-9. PMID 16929317 DOI: 10.1038/nmeth924  0.36
2006 Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 442: 818-22. PMID 16862118 DOI: 10.1038/nature04980  0.36
2006 Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, Flotte TJ, Duncan LM, Granter SR, Chin L. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell. 125: 1269-81. PMID 16814714 DOI: 10.1016/j.cell.2006.06.008  0.4
2006 Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M. Androgen-dependent regulation of Her-2/neu in prostate cancer cells. Cancer Research. 66: 5723-8. PMID 16740710 DOI: 10.1158/0008-5472.CAN-05-3928  0.36
2006 Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum Journal of Biological Chemistry. 281: 23003-23012. PMID 16717086 DOI: 10.1074/jbc.M602648200  0.36
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, ... Hahn WC, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/j.cell.2006.01.040  0.36
2005 Goessel G, Quante M, Hahn WC, Karada H, Heeg S, Suliman Y, Doebele M, Von Werder A, Fulda C, Nakagawa H, Rustgi AK, Blum HE, Opitz OG. Creating oral squamous cancer cells: A cellular model of oral-esophageal carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. 102: 15599-15604. PMID 16239349 DOI: 10.1073/pnas.0409730102  0.36
2005 Greulich H, Chen TH, Feng W, Jänne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. Plos Medicine. 2: e313. PMID 16187797 DOI: 10.1371/journal.pmed.0020313  0.36
2005 Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM. The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors Developmental Cell. 9: 327-338. PMID 16139224 DOI: 10.1016/j.devcel.2005.07.014  0.36
2005 Boehm JS, Hahn WC. Cancer genetics: Finding the right mix European Journal of Human Genetics : Ejhg. 13: 1099-1100. PMID 16077731  0.4
2005 Nakamura M, Masutomi K, Kyo S, Hashimoto M, Maida Y, Kanaya T, Tanaka M, Hahn WC, Inoue M. Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy. Human Gene Therapy. 16: 859-68. PMID 16000067 DOI: 10.1089/hum.2005.16.859  0.36
2005 Hahn WC. Telomere and telomerase dynamics in human cells Current Molecular Medicine. 5: 227-231. PMID 15974877 DOI: 10.2174/1566524053586572  0.36
2005 Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America. 102: 8222-7. PMID 15928077 DOI: 10.1073/pnas.0503095102  0.36
2005 Hashimoto M, Kyo S, Masutomi K, Maida Y, Sakaguchi J, Mizumoto Y, Nakamura M, Hahn WC, Inoue M. Analysis of telomeric single-strand overhang length in human endometrial cancers Febs Letters. 579: 2959-2964. PMID 15893755 DOI: 10.1016/j.febslet.2005.04.021  0.36
2005 Yu EY, Hahn WC. Genetic alterations in prostate cancer Clinical Prostate Cancer. 3: 220-229. PMID 15882478  0.36
2005 Boehm JS, Hahn WC. Finding the right mix European Journal of Human Genetics. 13: 1099-1105. DOI: 10.1038/sj.ejhg.5201477  0.36
2004 Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Research. 64: 8867-75. PMID 15604246 DOI: 10.1158/0008-5472.CAN-04-2938  0.36
2004 Chiang YJ, Hemann MT, Hathcock KS, Tessarollo L, Feigenbaum L, Hahn WC, Hodes RJ. Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo. Molecular and Cellular Biology. 24: 7024-31. PMID 15282303 DOI: 10.1128/MCB.24.16.7024-7031.2004  0.36
2004 Zhao JJ, Roberts TM, Hahn WC. Functional genetics and experimental models of human cancer. Trends in Molecular Medicine. 10: 344-50. PMID 15242683 DOI: 10.1016/j.molmed.2004.05.005  0.36
2004 Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, Counter CM, Nevins JR, Means AR, Sears R. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nature Cell Biology. 6: 308-18. PMID 15048125 DOI: 10.1038/ncb1110  0.36
2004 Liu J, Yang G, Thompson-Lanza JA, Glassman A, Hayes K, Patterson A, Marquez RT, Auersperg N, Yu Y, Hahn WC, Mills GB, Bast RC. A genetically defined model for human ovarian cancer. Cancer Research. 64: 1655-63. PMID 14996724 DOI: 10.1158/0008-5472.CAN-03-3380  0.36
2004 Baykal A, Thompson JA, Xu XC, Hahn WC, Deavers MT, Malpica A, Gershenson DM, Silva EG, Liu J. In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues. Oncology Reports. 11: 297-302. PMID 14719058  0.36
2003 Masutomi K, Hahn WC. Telomerase expression: Only half the story Cancer Biology and Therapy. 2: 685-686. PMID 14688477 DOI: 10.4161/cbt.2.6.557  0.36
2003 Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC. Telomerase maintains telomere structure in normal human cells. Cell. 114: 241-53. PMID 12887925 DOI: 10.1016/S0092-8674(03)00550-6  0.36
2003 Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell. 3: 483-95. PMID 12781366 DOI: 10.1016/S1535-6108(03)00088-6  0.36
2003 Hahn WC. Role of telomeres and telomerase in the pathogenesis of human cancer Journal of Clinical Oncology. 21: 2034-2043. PMID 12743159 DOI: 10.1200/JCO.2003.06.018  0.36
2003 Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG. Chemosensitivity linked to p73 function Cancer Cell. 3: 403-410. PMID 12726865 DOI: 10.1016/S1535-6108(03)00078-3  0.36
2003 Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM. Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Molecular and Cellular Biology. 23: 2859-70. PMID 12665584 DOI: 10.1128/MCB.23.8.2859-2870.2003  0.36
2003 Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. Rna (New York, N.Y.). 9: 493-501. PMID 12649500 DOI: 10.1261/rna.2192803  0.36
2002 Hahn WC, Weinberg RA. Rules for making human tumor cells New England Journal of Medicine. 347: 1593-1603. PMID 12432047 DOI: 10.1056/NEJMra021902  0.36
2002 Stewart SA, Hahn WC. Prospects for anti-neoplastic therapies based on telomere biology. Current Cancer Drug Targets. 2: 1-17. PMID 12188917 DOI: 10.2174/1568009023334015  0.36
2002 Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nature Medicine. 8: 979-86. PMID 12185362 DOI: 10.1038/nm754  0.36
2002 Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O'Toole KM. A two-stage, p16INK4A- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status Molecular and Cellular Biology. 22: 5157-5172. PMID 12077343 DOI: 10.1128/MCB.22.14.5157-5172.2002  0.36
2002 Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Molecular and Cellular Biology. 22: 2111-23. PMID 11884599 DOI: 10.1128/MCB.22.7.2111-2123.2002  0.36
Low-probability matches
2010 Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, et al. PTK6 regulates IGF-1-induced anchorage-independent survival. Plos One. 5: e11729. PMID 20668531 DOI: 10.1371/journal.pone.0011729  0.2
2019 Ghandi M, Huang FW, Jané-Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, ... ... Hahn WC, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. PMID 31068700 DOI: 10.1038/s41586-019-1186-3  0.12
2014 Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, Francis JM, Zhang CZ, Shalek AK, Satija R, Trombetta JJ, Lu D, Tallapragada N, Tahirova N, Kim S, ... ... Hahn WC, et al. Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nature Biotechnology. 32: 479-84. PMID 24752078 DOI: 10.1038/nbt.2892  0.12
2014 Riester M, Werner L, Bellmunt J, Selvarajah S, Guancial EA, Weir BA, Stack EC, Park RS, O'Brien R, Schutz FA, Choueiri TK, Signoretti S, Lloreta J, Marchionni L, Gallardo E, ... ... Hahn WC, et al. Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1873-83. PMID 24486590 DOI: 10.1158/1078-0432.CCR-13-0759  0.12
2012 Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, ... ... Hahn WC, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes & Development. 26: 756-84. PMID 22508724 DOI: 10.1101/gad.187922.112  0.12
2009 Balakumaran BS, Porrello A, Hsu DS, Glover W, Foye A, Leung JY, Sullivan BA, Hahn WC, Loda M, Febbo PG. MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. Cancer Research. 69: 7803-10. PMID 19773438 DOI: 10.1158/0008-5472.CAN-09-0910  0.12
2019 Dempster JM, Pacini C, Pantel S, Behan FM, Green T, Krill-Burger J, Beaver CM, Younger ST, Zhivich V, Najgebauer H, Allen F, Gonçalves E, Shepherd R, Doench JG, Yusa K, ... ... Hahn WC, et al. Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nature Communications. 10: 5817. PMID 31862961 DOI: 10.1038/s41467-019-13805-y  0.08
2019 Hwang JH, Seo JH, Beshiri ML, Wankowicz S, Liu D, Cheung A, Li J, Qiu X, Hong AL, Botta G, Golumb L, Richter C, So J, Sandoval GJ, Giacomelli AO, ... ... Hahn WC, et al. CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer. Cell Reports. 29: 2355-2370.e6. PMID 31747605 DOI: 10.1016/j.celrep.2019.10.068  0.08
2019 Wang X, Wang S, Troisi EC, Howard TP, Haswell JR, Wolf BK, Hawk WH, Ramos P, Oberlick EM, Tzvetkov EP, Ross A, Vazquez F, Hahn WC, Park PJ, Roberts CWM. Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors. Nature Communications. 10: 4445. PMID 31558726 DOI: 10.1038/s41467-019-12524-8  0.08
2019 Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, ... ... Hahn WC, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Reports. 28: 2331-2344.e8. PMID 31461650 DOI: 10.1016/j.celrep.2019.07.021  0.08
2019 Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, ... ... Hahn WC, et al. The landscape of cancer cell line metabolism. Nature Medicine. 25: 850-860. PMID 31068703 DOI: 10.1038/s41591-019-0404-8  0.08
2019 Wang X, Wang S, Troisi EC, Howard TP, Haswell JR, Wolf BK, Hawk WH, Ramos P, Oberlick EM, Tzvetkov EP, Vazquez F, Hahn WC, Park PJ, Roberts CWM. BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors. Nature Communications. 10: 1881. PMID 31015438 DOI: 10.1038/s41467-019-09891-7  0.08
2019 Price C, Gill S, Ho ZV, Davidson SM, Merkel E, McFarland JM, Leung L, Tang A, Kost-Alimova M, Tsherniak A, Jonas O, Vazquez F, Hahn WC. Genome-wide interrogation of human cancers identifies EGLN1 dependency in clear cell ovarian cancers. Cancer Research. PMID 30898838 DOI: 10.1158/0008-5472.CAN-18-2674  0.08
2019 Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Hahn WC, et al. Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition. Elife. 8. PMID 30860482 DOI: 10.7554/eLife.44161  0.08
2019 Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, ... ... Hahn WC, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metabolism. PMID 30799286 DOI: 10.1016/j.cmet.2019.01.020  0.08
2019 Hong AL, Guerriero JL, Doshi MB, Kynnap BD, Kim WJ, Schinzel AC, Modiste R, Schlauch AJ, Adam RM, Kwiatkowski DJ, Beroukhim R, Letai A, Rosenberg JE, Hahn WC. MCL1 and DEDD promote urothelial carcinoma progression. Molecular Cancer Research : McR. PMID 30777879 DOI: 10.1158/1541-7786.MCR-18-0963  0.08
2019 Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, ... ... Hahn WC, et al. MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Research. PMID 30755442 DOI: 10.1158/0008-5472.CAN-18-3066  0.08
2019 Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, ... ... Hahn WC, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine. PMID 30664779 DOI: 10.1038/s41591-018-0312-3  0.08
2018 Gannon HS, Zou T, Kiessling MK, Gao GF, Cai D, Choi PS, Ivan AP, Buchumenski I, Berger AC, Goldstein JT, Cherniack AD, Vazquez F, Tsherniak A, Levanon EY, Hahn WC, et al. Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nature Communications. 9: 5450. PMID 30575730 DOI: 10.1038/s41467-018-07824-4  0.08
2018 Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, ... ... Hahn WC, et al. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 175: 1972-1988.e16. PMID 30550791 DOI: 10.1016/j.cell.2018.11.021  0.08
2018 McFarland JM, Ho ZV, Kugener G, Dempster JM, Montgomery PG, Bryan JG, Krill-Burger JM, Green TM, Vazquez F, Boehm JS, Golub TR, Hahn WC, Root DE, Tsherniak A. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nature Communications. 9: 4610. PMID 30389920 DOI: 10.1038/s41467-018-06916-5  0.08
2018 Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, et al. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature Genetics. PMID 30127528 DOI: 10.1038/s41588-018-0191-z  0.08
2018 Viswanathan SR, Nogueira MF, Buss CG, Krill-Burger JM, Wawer MJ, Malolepsza E, Berger AC, Choi PS, Shih J, Taylor AM, Tanenbaum B, Pedamallu CS, Cherniack AD, Tamayo P, Strathdee CA, ... ... Hahn WC, et al. Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nature Genetics. PMID 29955178 DOI: 10.1038/s41588-018-0155-3  0.08
2018 Ng SY, Yoshida N, Christie AL, Ghandi M, Dharia NV, Dempster J, Murakami M, Shigemori K, Morrow SN, Van Scoyk A, Cordero NA, Stevenson KE, Puligandla M, Haas B, Lo C, ... ... Hahn WC, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nature Communications. 9: 2024. PMID 29789628 DOI: 10.1038/s41467-018-04356-9  0.08
2018 Pan J, Meyers RM, Michel BC, Mashtalir N, Sizemore AE, Wells JN, Cassel SH, Vazquez F, Weir BA, Hahn WC, Marsh JA, Tsherniak A, Kadoch C. Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens. Cell Systems. PMID 29778836 DOI: 10.1016/j.cels.2018.04.011  0.08
2017 Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, ... ... Hahn WC, et al. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. The Journal of Clinical Investigation. PMID 29202477 DOI: 10.1172/JCI90793  0.08
2017 Horn H, Lawrence MS, Chouinard CR, Shrestha Y, Hu JX, Worstell E, Shea E, Ilic N, Kim E, Kamburov A, Kashani A, Hahn WC, Campbell JD, Boehm JS, Getz G, et al. NetSig: network-based discovery from cancer genomes. Nature Methods. PMID 29200198 DOI: 10.1038/nmeth.4514  0.08
2017 Meyers RM, Bryan JG, McFarland JM, Weir BA, Sizemore AE, Xu H, Dharia NV, Montgomery PG, Cowley GS, Pantel S, Goodale A, Ali LD, Jiang G, Lubonja R, Harrington WF, ... ... Hahn WC, et al. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature Genetics. PMID 29083409 DOI: 10.1038/ng.3984  0.08
2017 Gönen M, Weir BA, Cowley GS, Vazquez F, Guan Y, Jaiswal A, Karasuyama M, Uzunangelov V, Wang T, Tsherniak A, Howell S, Marbach D, Hoff B, Norman TC, Airola A, ... ... Hahn WC, et al. A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines. Cell Systems. PMID 28988802 DOI: 10.1016/j.cels.2017.09.004  0.08
2017 Zhang X, Choi PS, Francis JM, Gao GF, Campbell JD, Ramachandran A, Mitsuishi Y, Ha G, Shih J, Vazquez F, Tsherniak A, Taylor AM, Zhou J, Wu Z, Berger AC, ... ... Hahn WC, et al. Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor. Cancer Discovery. PMID 28963353 DOI: 10.1158/2159-8290.CD-17-0532  0.08
2017 Tsherniak A, Vazquez F, Montgomery PG, Weir BA, Kryukov G, Cowley GS, Gill S, Harrington WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, ... ... Hahn WC, et al. Defining a Cancer Dependency Map. Cell. 170: 564-576.e16. PMID 28753430 DOI: 10.1016/j.cell.2017.06.010  0.08
2017 Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, ... ... Hahn WC, et al. Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Cancer Research. PMID 28655788 DOI: 10.1158/0008-5472.CAN-17-0216  0.08
2017 Rosenbluh J, Xu H, Harrington W, Gill S, Wang X, Vazquez F, Root DE, Tsherniak A, Hahn WC. Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression. Nature Communications. 8: 15403. PMID 28534478 DOI: 10.1038/ncomms15403  0.08
2017 Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, ... ... Hahn WC, et al. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 6. PMID 28177281 DOI: 10.7554/eLife.23268  0.08
2017 Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, et al. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro-Oncology. PMID 28082416 DOI: 10.1093/neuonc/now261  0.08
2016 Li H, Mar BG, Zhang H, Puram RV, Vazquez F, Weir BA, Hahn WC, Ebert B, Pellman D. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood. PMID 27756750 DOI: 10.1182/blood-2016-05-714493  0.08
2016 Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, ... ... Hahn WC, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.MCR-16-0090  0.08
2016 Kryukov GV, Wilson FH, Ruth JR, Paulk J, Tsherniak A, Marlow SE, Vazquez F, Weir BA, Fitzgerald ME, Tanaka M, Bielski CM, Scott JM, Dennis C, Cowley GS, Boehm JS, ... ... Hahn WC, et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science (New York, N.Y.). PMID 26912360 DOI: 10.1126/science.aad5214  0.08
2015 Huang FW, Bielski CM, Rinne ML, Hahn WC, Sellers WR, Stegmeier F, Garraway LA, Kryukov GV. TERT promoter mutations and monoallelic activation of TERT in cancer. Oncogenesis. 4: e176. PMID 26657580 DOI: 10.1038/oncsis.2015.39  0.08
2015 Gannon HS, Kaplan N, Tsherniak A, Vazquez F, Weir BA, Hahn WC, Meyerson M. Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-targeted Therapy. Molecular Cancer Research : McR. PMID 26582713 DOI: 10.1158/1541-7786.MCR-15-0321  0.08
2015 Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine. PMID 26552009 DOI: 10.1038/nm.3968  0.08
2015 Pomerantz MM, Li F, Takeda DY, Lenci R, Chonkar A, Chabot M, Cejas P, Vazquez F, Cook J, Shivdasani RA, Bowden M, Lis R, Hahn WC, Kantoff PW, Brown M, et al. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nature Genetics. PMID 26457646 DOI: 10.1038/ng.3419  0.08
2014 Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, ... ... Hahn WC, et al. Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Scientific Data. 1: 140044. PMID 25982629 DOI: 10.1038/sdata.2014.44  0.08
2014 Yao X, Choudhury AD, Yamanaka YJ, Adalsteinsson VA, Gierahn TM, Williamson CA, Lamb CR, Taplin ME, Nakabayashi M, Chabot MS, Li T, Lee GS, Boehm JS, Kantoff PW, Hahn WC, et al. Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 388-98. PMID 24522233 DOI: 10.1039/c3ib40264a  0.08
2014 Wilson BG, Helming KC, Wang X, Kim Y, Vazquez F, Jagani Z, Hahn WC, Roberts CW. Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Molecular and Cellular Biology. 34: 1136-44. PMID 24421395 DOI: 10.1128/MCB.01372-13  0.08
2014 Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA. An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 33: 5637-48. PMID 24317510 DOI: 10.1038/onc.2013.517  0.08
2013 Hagerstrand D, Tong A, Schumacher SE, Ilic N, Shen RR, Cheung HW, Vazquez F, Shrestha Y, Kim SY, Giacomelli AO, Rosenbluh J, Schinzel AC, Spardy NA, Barbie DA, Mermel CH, ... ... Hahn WC, et al. Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers. Cancer Discovery. 3: 1044-57. PMID 23764425 DOI: 10.1158/2159-8290.CD-12-0592  0.08
2013 Serra V, Eichhorn PJ, García-García C, Ibrahim YH, Prudkin L, Sánchez G, Rodríguez O, Antón P, Parra JL, Marlow S, Scaltriti M, Pérez-Garcia J, Prat A, Arribas J, Hahn WC, et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. The Journal of Clinical Investigation. 123: 2551-63. PMID 23635776 DOI: 10.1172/JCI66343  0.08
2013 Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, ... ... Hahn WC, et al. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proceedings of the National Academy of Sciences of the United States of America. 110: 8188-93. PMID 23633565 DOI: 10.1073/pnas.1300252110  0.08
2013 Shao DD, Tsherniak A, Gopal S, Weir BA, Tamayo P, Stransky N, Schumacher SE, Zack TI, Beroukhim R, Garraway LA, Margolin AA, Root DE, Hahn WC, Mesirov JP. ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens. Genome Research. 23: 665-78. PMID 23269662 DOI: 10.1101/gr.143586.112  0.08
2012 Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F, Cowley GS, ... ... Hahn WC, et al. β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell. 151: 1457-73. PMID 23245941 DOI: 10.1016/j.cell.2012.11.026  0.08
2012 Eck MJ, Hahn WC. EGFR in limbo. Cell. 149: 735-7. PMID 22579278 DOI: 10.1016/j.cell.2012.04.015  0.08
2011 Cheung HW, Du J, Boehm JS, He F, Weir BA, Wang X, Butaney M, Sequist LV, Luo B, Engelman JA, Root DE, Meyerson M, Golub TR, Jänne PA, Hahn WC. Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discovery. 1: 608-25. PMID 22586683 DOI: 10.1158/2159-8290.CD-11-0046  0.08
2011 Yang X, Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, ... ... Hahn WC, et al. A public genome-scale lentiviral expression library of human ORFs. Nature Methods. 8: 659-61. PMID 21706014 DOI: 10.1038/nmeth.1638  0.08
2011 Boehm JS, Hahn WC. Towards systematic functional characterization of cancer genomes. Nature Reviews. Genetics. 12: 487-98. PMID 21681210 DOI: 10.1038/nrg3013  0.08
2011 Chin L, Hahn WC, Getz G, Meyerson M. Making sense of cancer genomic data. Genes & Development. 25: 534-55. PMID 21406553 DOI: 10.1101/gad.2017311  0.08
2010 Kim SY, Dunn IF, Firestein R, Gupta P, Wardwell L, Repich K, Schinzel AC, Wittner B, Silver SJ, Root DE, Boehm JS, Ramaswamy S, Lander ES, Hahn WC. CK1epsilon is required for breast cancers dependent on beta-catenin activity. Plos One. 5: e8979. PMID 20126544 DOI: 10.1371/journal.pone.0008979  0.08
2009 Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 16: 413-24. PMID 19878873 DOI: 10.1016/j.ccr.2009.09.029  0.08
2009 Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, ... ... Hahn WC, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature. 462: 108-12. PMID 19847166 DOI: 10.1038/nature08460  0.08
2009 Rosenbluh J, Nijhawan D, Hahn WC. Regulating TERT: location, location, location. Cell Cycle (Georgetown, Tex.). 8: 3257. PMID 19823010  0.08
2009 Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, ... ... Hahn WC, et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell. 137: 821-34. PMID 19490892 DOI: 10.1016/j.cell.2009.03.017  0.08
2009 Hahn WC, Dunn IF, Kim SY, Schinzel AC, Firestein R, Guney I, Boehm JS. Integrative genomic approaches to understanding cancer. Biochimica Et Biophysica Acta. 1790: 478-84. PMID 19364473 DOI: 10.1016/j.bbagen.2009.02.003  0.08
2008 Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, ... ... Hahn WC, et al. Highly parallel identification of essential genes in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 20380-5. PMID 19091943 DOI: 10.1073/pnas.0810485105  0.08
2008 Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, ... ... Hahn WC, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 455: 547-51. PMID 18794900 DOI: 10.1038/nature07179  0.08
2008 Westermarck J, Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation Trends in Molecular Medicine. 14: 152-160. PMID 18329957 DOI: 10.1016/j.molmed.2008.02.001  0.08
2007 Kim SY, Hahn WC. Cancer genomics: Integrating form and function Carcinogenesis. 28: 1387-1392. PMID 17434922 DOI: 10.1093/carcin/bgm086  0.08
2006 Polyak K, Hahn WC. Roots and stems: Stem cells in cancer Nature Medicine. 12: 296-300. PMID 16520777 DOI: 10.1038/nm1379  0.08
2005 Boehm JS, Hession MT, Bulmer SE, Hahn WC. Transformation of human and murine fibroblasts without viral oncoproteins Molecular and Cellular Biology. 25: 6464-6474. PMID 16024784 DOI: 10.1128/MCB.25.15.6464-6474.2005  0.08
2020 Kim JW, Berrios C, Kim M, Schade AE, Adelmant G, Yeerna H, Damato E, Iniguez AB, Florens L, Washburn MP, Stegmaier K, Gray NS, Tamayo P, Gjoerup O, Marto JA, ... ... Hahn WC, et al. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. Elife. 9. PMID 31913126 DOI: 10.7554/eLife.53003  0.04
2019 Boettcher S, Miller PG, Sharma R, McConkey M, Leventhal M, Krivtsov AV, Giacomelli AO, Wong W, Kim J, Chao S, Kurppa KJ, Yang X, Milenkowic K, Piccioni F, Root DE, ... ... Hahn WC, et al. A dominant-negative effect drives selection of missense mutations in myeloid malignancies. Science (New York, N.Y.). 365: 599-604. PMID 31395785 DOI: 10.1126/science.aax3649  0.04
2019 Goyal L, Shi L, Liu LY, Fece de la Cruz F, Lennerz JK, Raghavan S, Leshchiner I, Elagina L, Siravegna G, Ng RWS, Vu P, Patra KC, Saha SK, Uppot RN, Arellano R, ... ... Hahn WC, et al. TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma. Cancer Discovery. PMID 31109923 DOI: 10.1158/2159-8290.CD-19-0182  0.04
2017 Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, ... ... Hahn WC, et al. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. Jama Oncology. PMID 29098284 DOI: 10.1001/jamaoncol.2017.3420  0.04
2017 Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nature Communications. 8: 15918. PMID 28607496 DOI: 10.1038/ncomms15918  0.04
2017 Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, ... ... Hahn WC, et al. Synergistic interactions with PI3K inhibition that induce apoptosis. Elife. 6. PMID 28561737 DOI: 10.7554/eLife.24523  0.04
2017 Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nature Communications. 8: 15110. PMID 28447610 DOI: 10.1038/ncomms15110  0.04
2016 Sholl LM, Do K, Shivdasani P, Cerami E, Dubuc AM, Kuo FC, Garcia EP, Jia Y, Davineni P, Abo RP, Pugh TJ, van Hummelen P, Thorner AR, Ducar M, Berger AH, ... ... Hahn WC, et al. Institutional implementation of clinical tumor profiling on an unselected cancer population. Jci Insight. 1: e87062. PMID 27882345 DOI: 10.1172/jci.insight.87062  0.04
2015 Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nature Medicine. 21: 335-43. PMID 25822366 DOI: 10.1038/nm.3832  0.04
2015 Wilson FH, Johannessen CM, Piccioni F, Tamayo P, Kim JW, Van Allen EM, Corsello SM, Capelletti M, Calles A, Butaney M, Sharifnia T, Gabriel SB, Mesirov JP, Hahn WC, Engelman JA, et al. A functional landscape of resistance to ALK inhibition in lung cancer. Cancer Cell. 27: 397-408. PMID 25759024 DOI: 10.1016/j.ccell.2015.02.005  0.04
2015 Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, Curtis J, Piao H, Wong LC, Kung AL, Beroukhim R, Bradner JE, Drapkin R, Hahn WC, Liu JF, et al. An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 112: 232-7. PMID 25535366 DOI: 10.1073/pnas.1422165112  0.04
2015 Chen L, Lai Y, Zhu X, Ma L, Bai Q, Vazquez I, Xiao Y, Liu C, Li D, Gao C, He Z, Zeng X, Xing X, Zhang Z, Li J, ... ... Hahn WC, et al. The role of specific PP2A complexes in the dephosphorylation of γH2AX. Journal of Cell Science. 128: 421. PMID 25236601 DOI: 10.1242/jcs.147223  0.04
2014 Barbie TU, Alexe G, Aref AR, Li S, Zhu Z, Zhang X, Imamura Y, Thai TC, Huang Y, Bowden M, Herndon J, Cohoon TJ, Fleming T, Tamayo P, Mesirov JP, ... ... Hahn WC, et al. Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth. The Journal of Clinical Investigation. 124: 5411-23. PMID 25365225 DOI: 10.1172/JCI75661  0.04
2014 Giannakis M, Hodis E, Jasmine Mu X, Yamauchi M, Rosenbluh J, Cibulskis K, Saksena G, Lawrence MS, Qian ZR, Nishihara R, Van Allen EM, Hahn WC, Gabriel SB, Lander ES, Getz G, et al. RNF43 is frequently mutated in colorectal and endometrial cancers. Nature Genetics. 46: 1264-6. PMID 25344691 DOI: 10.1038/ng.3127  0.04
2014 Kim YM, Lee SW, Chun SM, Kim DY, Kim JH, Kim KR, Kim YT, Nam JH, van Hummelen P, MacConaill LE, Hahn WC, Jang SJ. Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples. Plos One. 9: e99451. PMID 24936796 DOI: 10.1371/journal.pone.0099451  0.04
2014 Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, et al. Requirement for CDK6 in MLL-rearranged acute myeloid leukemia. Blood. 124: 13-23. PMID 24764564 DOI: 10.1182/blood-2014-02-558114  0.04
2013 Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, et al. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Reports. 3: 747-58. PMID 23453972 DOI: 10.1016/j.celrep.2013.01.033  0.04
2013 Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, et al. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes & Development. 27: 197-210. PMID 23322301 DOI: 10.1101/gad.203208.112  0.04
2012 Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, ... ... Hahn WC, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proceedings of the National Academy of Sciences of the United States of America. 109: 14476-81. PMID 22908275 DOI: 10.1073/pnas.1203201109  0.04
2012 Grisanzio C, Werner L, Takeda D, Awoyemi BC, Pomerantz MM, Yamada H, Sooriakumaran P, Robinson BD, Leung R, Schinzel AC, Mills I, Ross-Adams H, Neal DE, Kido M, Yamamoto T, ... ... Hahn WC, et al. Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11252-7. PMID 22730461 DOI: 10.1073/pnas.1200853109  0.04
2012 Wagle N, Berger MF, Davis MJ, Blumenstiel B, Defelice M, Pochanard P, Ducar M, Van Hummelen P, Macconaill LE, Hahn WC, Meyerson M, Gabriel SB, Garraway LA. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discovery. 2: 82-93. PMID 22585170 DOI: 10.1158/2159-8290.CD-11-0184  0.04
2011 Rosenbluh J, Nijhawan D, Chen Z, Wong KK, Masutomi K, Hahn WC. RMRP is a non-coding RNA essential for early murine development. Plos One. 6: e26270. PMID 22039455 DOI: 10.1371/journal.pone.0026270  0.04
2011 Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, ... ... Hahn WC, et al. Initial genome sequencing and analysis of multiple myeloma. Nature. 471: 467-72. PMID 21430775 DOI: 10.1038/nature09837  0.04
2010 Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 116: 1919-23. PMID 20519626 DOI: 10.1182/blood-2010-04-279083  0.04
2009 Hahn CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K, Schinzel AC, Ross L, Galinsky I, Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M, Hahn WC, et al. Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell. 16: 281-94. PMID 19800574 DOI: 10.1016/j.ccr.2009.08.018  0.04
2005 Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC. Cancer-associated PP2A Aα subunits induce functional haploinsufficiency and tumorigenicity Cancer Research. 65: 8183-8192. PMID 16166293 DOI: 10.1158/0008-5472.CAN-05-1103  0.04
2020 Rafiei S, Fitzpatrick K, Liu D, Cai MY, Elmarakeby HA, Park J, Ricker C, Kochupurakkal BS, Choudhury AD, Hahn WC, Balk SP, Hwang JH, Van Allen EM, Mouw KW. ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer. Cancer Research. PMID 32127357 DOI: 10.1158/0008-5472.CAN-19-3126  0.01
2019 Hahn WC. A CRISPR Way to Identify Cancer Targets. The New England Journal of Medicine. 380: 2475-2477. PMID 31216404 DOI: 10.1056/NEJMcibr1905048  0.01
2018 Choudhury AD, Werner L, Francini E, Wei XX, Ha G, Freeman SS, Rhoades J, Reed SC, Gydush G, Rotem D, Lo C, Taplin ME, Harshman LC, Zhang Z, O'Connor EP, ... ... Hahn WC, et al. Tumor fraction in cell-free DNA as a biomarker in prostate cancer. Jci Insight. 3. PMID 30385733 DOI: 10.1172/jci.insight.122109  0.01
2018 Ng K, Hendifar A, Starodub A, Chaves J, Yang Y, Koh B, Barbie D, Hahn WC, Fuchs CS. Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. Investigational New Drugs. PMID 30105668 DOI: 10.1007/s10637-018-0650-5  0.01
2018 Sandoval GJ, Pulice JL, Pakula H, Schenone M, Takeda DY, Pop M, Boulay G, Williamson KE, McBride MJ, Pan J, St Pierre R, Hartman E, Garraway LA, Carr SA, Rivera MN, ... ... Hahn WC, et al. Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. Molecular Cell. PMID 30078722 DOI: 10.1016/j.molcel.2018.06.040  0.01
2018 Takeda DY, Spisák S, Seo JH, Bell C, O'Connor E, Korthauer K, Ribli D, Csabai I, Solymosi N, Szállási Z, Stillman DR, Cejas P, Qiu X, Long HW, Tisza V, ... ... Hahn WC, et al. A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer. Cell. PMID 29909987 DOI: 10.1016/j.cell.2018.05.037  0.01
2017 Sandoval GJ, Hahn WC. Going beyond genetics to discover cancer targets. Genome Biology. 18: 95. PMID 28532420 DOI: 10.1186/s13059-017-1238-7  0.01
2016 Choudhury AD, Schinzel AC, Cotter MB, Lis RT, Labella K, Lock YJ, Izzo F, Guney I, Bowden M, Li YY, Patel J, Hartman E, Carr SA, Schenone M, Jaffe JD, ... ... Hahn WC, et al. Castration resistance in prostate cancer is mediated by the kinase NEK6. Cancer Research. PMID 27899381 DOI: 10.1158/0008-5472.CAN-16-0455  0.01
2016 Bellmunt J, Zhou CW, Mullane SA, Werner L, Taplin ME, Fay AP, Choueiri TK, Orsola A, Takeda DY, Hahn WC, Kim J, Sonpavde G, Bowden M. Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy. British Journal of Cancer. 115: 12-19. PMID 27351382 DOI: 10.1038/bjc.2016.146  0.01
2015 Luo LY, Hahn WC. Oncogenic Signaling Adaptor Proteins. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 42: 521-9. PMID 26554907 DOI: 10.1016/j.jgg.2015.09.001  0.01
2015 Hettmer S, Schinzel AC, Tchessalova D, Schneider M, Parker CL, Bronson R, Richards NG, Hahn W, Wagers AJ. Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. Elife. 4. PMID 26499495 DOI: 10.7554/eLife.09436  0.01
2015 Baselga J, Bhardwaj N, Cantley LC, DeMatteo R, DuBois RN, Foti M, Gapstur SM, Hahn WC, Helman LJ, Jensen RA, Paskett ED, Lawrence TS, Lutzker SG, Szabo E. AACR Cancer Progress Report 2015. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: S1-S128. PMID 26429991 DOI: 10.1158/1078-0432.CCR-15-1846  0.01
2015 Shen RR, Zhou AY, Kim E, O'Connell JT, Hagerstrand D, Beroukhim R, Hahn WC. TRAF2 is an NF-κB-activating oncogene in epithelial cancers. Oncogene. 34: 209-16. PMID 24362534 DOI: 10.1038/onc.2013.543  0.01
2015 Shrestha Y, Hahn WC. Regulatory signaling networks in cell transformation and cancer Systems Biology of Cancer. 169-182. DOI: 10.1017/9780511979811.012  0.01
2014 Hahn WC, Weinberg RA. Cancer: A Genetic Disorder The Molecular Basis of Cancer: Fourth Edition. 3-18.e1. DOI: 10.1016/B978-1-4557-4066-6.00001-9  0.01
2013 Wright AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E, Van Hummelen P, MacConaill LE, Shoni M, Wagle N, Jones RT, Quick CM, Laury A, Katz IT, Hahn WC, Matulonis UA, et al. Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer. 119: 3776-83. PMID 24037752 DOI: 10.1002/cncr.28288  0.01
2013 Etemadmoghadam D, Au-Yeung G, Wall M, Mitchell C, Kansara M, Loehrer E, Batzios C, George J, Ftouni S, Weir BA, Carter S, Gresshoff I, Mileshkin L, Rischin D, Hahn WC, et al. Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5960-71. PMID 24004674 DOI: 10.1158/1078-0432.CCR-13-1337  0.01
2012 Shen RR, Zhou AY, Kim E, Lim E, Habelhah H, Hahn WC. IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation. Molecular and Cellular Biology. 32: 4756-68. PMID 23007157 DOI: 10.1128/MCB.00468-12  0.01
2012 Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, Harbour JW, Garraway LA, Kim IK. High throughput mass spectrometry-based mutation profiling of primary uveal melanoma. Investigative Ophthalmology & Visual Science. 53: 6991-6. PMID 22977135 DOI: 10.1167/iovs.12-10427  0.01
2012 Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Molecular and Cellular Biology. 32: 3963-77. PMID 22851694 DOI: 10.1128/MCB.00436-12  0.01
2012 Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S. Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4. Blood. 120: 1095-106. PMID 22718837 DOI: 10.1182/blood-2012-03-415984  0.01
2012 Masutomi K, Hahn WC. Off-Telomere Functions of Telomerase Telomerases: Chemistry, Biology, and Clinical Applications. 201-212. DOI: 10.1002/9781118268667.ch8  0.01
2011 MacConaill LE, Van Hummelen P, Meyerson M, Hahn WC. Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges. Cancer Discovery. 1: 297-311. PMID 21935500 DOI: 10.1158/2159-8290.CD-11-0110  0.01
2011 Matulonis UA, Hirsch M, Palescandolo E, Kim E, Liu J, van Hummelen P, MacConaill L, Drapkin R, Hahn WC. High throughput interrogation of somatic mutations in high grade serous cancer of the ovary. Plos One. 6: e24433. PMID 21931712 DOI: 10.1371/journal.pone.0024433  0.01
2011 Okamoto N, Yasukawa M, Nguyen C, Kasim V, Maida Y, Possemato R, Shibata T, Ligon KL, Fukami K, Hahn WC, Masutomi K. Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proceedings of the National Academy of Sciences of the United States of America. 108: 20388-93. PMID 21730156 DOI: 10.1073/pnas.1015171108  0.01
2011 Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, et al. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 82: 17-33. PMID 21108995 DOI: 10.1016/j.fitote.2010.11.017  0.01
2011 Shen RR, Hahn WC. Emerging roles for the non-canonical IKKs in cancer. Oncogene. 30: 631-41. PMID 21042276 DOI: 10.1038/onc.2010.493  0.01
2010 Garraway LA, Hahn WC. On or off target: mutations, models, and predictions. Science Translational Medicine. 2: 35ps28. PMID 20538617 DOI: 10.1126/scitranslmed.3001263  0.01
2009 Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Molecular Cell. 34: 461-72. PMID 19481526 DOI: 10.1016/j.molcel.2009.04.031  0.01
2008 Possemato R, Timmons JC, Bauerlein EL, Wada N, Baldwin A, Masutomi K, Hahn WC. Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics Molecular Cancer Research. 6: 1582-1593. PMID 18922974 DOI: 10.1158/1541-7786.MCR-08-0070  0.01
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/journal.pone.0002020  0.01
2008 Arroyo JD, Lee GM, Hahn WC. Liprinα1 interacts with PP2A B56γ Cell Cycle. 7: 525-532. PMID 18235218  0.01
2008 Lee J, Sung YH, Cheong C, Choi YS, Jeon HK, Sun W, Hahn WC, Ishikawa F, Lee HW. TERT promotes cellular and organismal survival independently of telomerase activity Oncogene. 27: 3754-3760. PMID 18223679 DOI: 10.1038/sj.onc.1211037  0.01
2008 Sablina AA, Hahn WC. SV40 small T antigen and PP2A phosphatase in cell transformation Cancer and Metastasis Reviews. 27: 137-146. PMID 18214640 DOI: 10.1007/s10555-008-9116-0  0.01
2008 Schinzel AC, Hahn WC. Oncogenic transformation and experimental models of human cancer Frontiers in Bioscience. 13: 71-84. PMID 17981529 DOI: 10.2741/2661  0.01
2007 Cho US, Morrone S, Sablina AA, Arroyo JD, Hahn WC, Xu W. Structural basis of PP2A inhibition by small t antigen. Plos Biology. 5: e202. PMID 17608567 DOI: 10.1371/journal.pbio.0050202  0.01
2007 Park Y, Downing SR, Kim D, Hahn WC, Li C, Kantoff PW, Wei LJ. Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: Application to mass spec data Bioinformatics. 23: 1451-1458. PMID 17459967 DOI: 10.1093/bioinformatics/btm130  0.01
2006 Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, ... Hahn WC, et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 127: 759-73. PMID 17110335 DOI: 10.1016/j.cell.2006.10.035  0.01
2006 Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 10: 321-30. PMID 17010675 DOI: 10.1016/j.ccr.2006.09.005  0.01
2006 Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, et al. Minimizing the risk of reporting false positives in large-scale RNAi screens. Nature Methods. 3: 777-9. PMID 16990807 DOI: 10.1038/nmeth1006-777  0.01
2005 Arroyo JD, Hahn WC. Involvement of PP2A in viral and cellular transformation Oncogene. 24: 7746-7755. PMID 16299534 DOI: 10.1038/sj.onc.1209038  0.01
2005 Dong CK, Masutomi K, Hahn WC. Telomerase: regulation, function and transformation. Critical Reviews in Oncology/Hematology. 54: 85-93. PMID 15843091 DOI: 10.1016/j.critrevonc.2004.12.005  0.01
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