Thomas N. Seyfried - Publications

Affiliations: 
Boston College, Newton, MA, United States 
Area:
metabolic therapy

164 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Communications Biology. 2: 200. PMID 31149644 DOI: 10.1038/s42003-019-0455-x  0.8
2019 Seyfried TN, Shelton L, Arismendi-Morillo G, Kalamian M, Elsakka A, Maroon J, Mukherjee P. Provocative Question: Should Ketogenic Metabolic Therapy Become the Standard of Care for Glioblastoma? Neurochemical Research. PMID 31025151 DOI: 10.1007/s11064-019-02795-4  0.72
2018 Wallace TC, Bultman S, D'Adamo C, Daniel CR, Debelius J, Ho E, Eliassen H, Lemanne D, Mukherjee P, Seyfried TN, Tian Q, Vahdat LT. Personalized Nutrition in Disrupting Cancer - Proceedings From the 2017 American College of Nutrition Annual Meeting. Journal of the American College of Nutrition. 1-14. PMID 30511901 DOI: 10.1080/07315724.2018.1500499  0.72
2018 Augur ZM, Doyle CM, Li M, Mukherjee P, Seyfried TN. Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma. Frontiers in Nutrition. 5: 91. PMID 30349820 DOI: 10.3389/fnut.2018.00091  0.72
2018 Elsakka AMA, Bary MA, Abdelzaher E, Elnaggar M, Kalamian M, Mukherjee P, Seyfried TN. Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up. Frontiers in Nutrition. 5: 20. PMID 29651419 DOI: 10.3389/fnut.2018.00020  0.72
2018 Chen E, Kiebish MA, McDaniel J, Niedzwiecka K, Kucharczyk R, Ravasz D, Gao F, Narain NR, Sarangarajan R, Seyfried TN, Adam-Vizi V, Chinopoulos C. Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT. Scientific Reports. 8: 5915. PMID 29651047 DOI: 10.1038/s41598-018-24305-2  0.8
2018 Flores RE, Brown AK, Taus L, Khoury J, Glover F, Kami K, Sarangarajan R, Walshe T, Narain NR, Kiebish MA, Shelton L, Chinopoulos C, Seyfried TN. Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells. Biochimica Et Biophysica Acta. PMID 29580805 DOI: 10.1016/j.bbabio.2018.03.012  0.8
2016 Chen E, Kiebish MA, McDaniel J, Gao F, Narain NR, Sarangarajan R, Kacso G, Ravasz D, Seyfried TN, Adam-Vizi V, Chinopoulos C. The total and mitochondrial lipidome of Artemia franciscana encysted embryos. Biochimica Et Biophysica Acta. PMID 27542539 DOI: 10.1016/j.bbalip.2016.08.007  1
2015 Schneider JS, Seyfried TN, Choi HS, Kidd SK. Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease. Plos One. 10: e0143351. PMID 26629687 DOI: 10.1371/journal.pone.0143351  1
2015 Ta NL, Seyfried TN. Influence of Serum and Hypoxia on Incorporation of [(14)C]-D-Glucose or [(14)C]-L-Glutamine into Lipids and Lactate in Murine Glioblastoma Cells. Lipids. PMID 26537505 DOI: 10.1007/s11745-015-4075-z  1
2015 Akgoc Z, Iosim S, Seyfried TN. Bis(monoacylglycero)phosphate as a Macrophage Enriched Phospholipid. Lipids. 50: 907-12. PMID 26205346 DOI: 10.1007/s11745-015-4045-5  1
2015 Rockwell HE, McCurdy VJ, Eaton SC, Wilson DU, Johnson AK, Randle AN, Bradbury AM, Gray-Edwards HL, Baker HJ, Hudson JA, Cox NR, Sena-Esteves M, Seyfried TN, Martin DR. AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. Asn Neuro. 7. PMID 25873306 DOI: 10.1177/1759091415569908  1
2015 Meidenbauer JJ, Mukherjee P, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutrition & Metabolism. 12: 12. PMID 25798181 DOI: 10.1186/s12986-015-0009-2  1
2015 Akgoc Z, Sena-Esteves M, Martin DR, Han X, d'Azzo A, Seyfried TN. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses. Journal of Lipid Research. 56: 1006-13. PMID 25795792 DOI: 10.1194/jlr.M057851  1
2015 Heinecke KA, Luoma A, d'Azzo A, Kirschner DA, Seyfried TN. Myelin abnormalities in the optic and sciatic nerves in mice with GM1-gangliosidosis. Asn Neuro. 7. PMID 25694553 DOI: 10.1177/1759091415568913  1
2015 McCurdy VJ, Rockwell HE, Arthur JR, Bradbury AM, Johnson AK, Randle AN, Brunson BL, Hwang M, Gray-Edwards HL, Morrison NE, Johnson JA, Baker HJ, Cox NR, Seyfried TN, Sena-Esteves M, et al. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. Gene Therapy. 22: 181-9. PMID 25474439 DOI: 10.1038/gt.2014.108  1
2015 Seyfried TN, Flores R, Poff AM, D'Agostino DP, Mukherjee P. Metabolic therapy: a new paradigm for managing malignant brain cancer. Cancer Letters. 356: 289-300. PMID 25069036 DOI: 10.1016/j.canlet.2014.07.015  1
2015 Poff AM, Ward N, Seyfried TN, Arnold P, D'Agostino DP. Non-toxic metabolic management of metastatic cancer in VM mice: Novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy Plos One. 10. DOI: 10.1371/journal.pone.0127407  1
2014 Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proceedings of the National Academy of Sciences of the United States of America. 111: 16647-53. PMID 25404320 DOI: 10.1073/pnas.1413965111  1
2014 Seyfried TN, Rockwell HE, Heinecke KA, Martin DR, Sena-Esteves M. Ganglioside storage diseases: on the road to management. Advances in Neurobiology. 9: 485-99. PMID 25151393 DOI: 10.1007/978-1-4939-1154-7_22  0.76
2014 Seyfried TN. Ketone strong: emerging evidence for a therapeutic role of ketone bodies in neurological and neurodegenerative diseases. Journal of Lipid Research. 55: 1815-7. PMID 25015970 DOI: 10.1194/jlr.E052944  1
2014 Mantis JG, Meidenbauer JJ, Zimick NC, Centeno NA, Seyfried TN. Glucose reduces the anticonvulsant effects of the ketogenic diet in EL mice. Epilepsy Research. 108: 1137-44. PMID 24938543 DOI: 10.1016/j.eplepsyres.2014.05.010  1
2014 Meidenbauer JJ, Ta N, Seyfried TN. Influence of a ketogenic diet, fish-oil, and calorie restriction on plasma metabolites and lipids in C57BL/6J mice. Nutrition & Metabolism. 11: 23. PMID 24910707 DOI: 10.1186/1743-7075-11-23  1
2014 Poff AM, Ari C, Arnold P, Seyfried TN, D'Agostino DP. Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer. International Journal of Cancer. Journal International Du Cancer. 135: 1711-20. PMID 24615175 DOI: 10.1002/ijc.28809  1
2014 Muthupalani S, Torres PA, Wang BC, Zeng BJ, Eaton S, Erdelyi I, Ducore R, Maganti R, Keating J, Perry BJ, Tseng FS, Waliszewski N, Pokras M, Causey R, Seger R, ... ... Seyfried T, et al. GM1-gangliosidosis in American black bears: clinical, pathological, biochemical and molecular genetic characterization. Molecular Genetics and Metabolism. 111: 513-21. PMID 24581871 DOI: 10.1016/j.ymgme.2014.02.002  1
2014 Dufort FJ, Gumina MR, Ta NL, Tao Y, Heyse SA, Scott DA, Richardson AD, Seyfried TN, Chiles TC. Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. The Journal of Biological Chemistry. 289: 7011-24. PMID 24469453 DOI: 10.1074/jbc.M114.551051  1
2014 Seyfried TN, Flores RE, Poff AM, D'Agostino DP. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 35: 515-27. PMID 24343361 DOI: 10.1093/carcin/bgt480  1
2014 Ta NL, Jia X, Kiebish M, Seyfried TN. Autosomal dominant inheritance of brain cardiolipin fatty acid abnormality in VM/DK mice: association with hypoxic-induced cognitive insensitivity. Lipids. 49: 113-7. PMID 24243001 DOI: 10.1007/s11745-013-3857-4  1
2013 Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, et al. A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 2136-47. PMID 23817205 DOI: 10.1038/mt.2013.138  1
2013 Poff AM, Ari C, Seyfried TN, D'Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. Plos One. 8: e65522. PMID 23755243 DOI: 10.1371/journal.pone.0065522  1
2013 Bradbury AM, Cochran JN, McCurdy VJ, Johnson AK, Brunson BL, Gray-Edwards H, Leroy SG, Hwang M, Randle AN, Jackson LS, Morrison NE, Baek RC, Seyfried TN, Cheng SH, Cox NR, et al. Therapeutic response in feline sandhoff disease despite immunity to intracranial gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1306-15. PMID 23689599 DOI: 10.1038/mt.2013.86  1
2013 Arthur JR, Wilson MW, Larsen SD, Rockwell HE, Shayman JA, Seyfried TN. Ethylenedioxy-PIP2 oxalate reduces ganglioside storage in juvenile Sandhoff disease mice. Neurochemical Research. 38: 866-75. PMID 23417430 DOI: 10.1007/s11064-013-0992-5  1
2013 Seyfried TN, Huysentruyt LC. On the origin of cancer metastasis. Critical Reviews in Oncogenesis. 18: 43-73. PMID 23237552 DOI: 10.1615/CritRevOncog.v18.i1-2.40  1
2013 Seyfried TN, Shelton LM, Huysentruyt LC. The VM mouse model of glioblastoma multiforme Neuromethods. 77: 39-55. DOI: 10.1007/7657_2012_34  1
2012 Arthur JR, Lee JP, Snyder EY, Seyfried TN. Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice. Neurochemical Research. 37: 1335-43. PMID 22367451 DOI: 10.1007/s11064-012-0718-0  1
2012 Urits I, Mukherjee P, Meidenbauer J, Seyfried TN. Dietary restriction promotes vessel maturation in a mouse astrocytoma. Journal of Oncology. 2012: 264039. PMID 22253625 DOI: 10.1155/2012/264039  1
2012 Seyfried TN, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Research. 100: 310-26. PMID 21885251 DOI: 10.1016/j.eplepsyres.2011.06.017  1
2012 Benjamins JA, Murphy EJ, Seyfried TN. Lipids Basic Neurochemistry. 81-100. DOI: 10.1016/B978-0-12-374947-5.00005-5  1
2012 Seyfried TN, Chuang JH, Zhang L, Han X, Kiebish MA. The Tumor Mitochondrial Lipidome and Respiratory Bioenergetic Insufficiency Lipidomics: Technologies and Applications. 297-317. DOI: 10.1002/9783527655946.ch15  1
2012 Seyfried TN. Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer. DOI: 10.1002/9781118310311  1
2012 Maroon J, Bost J, LePere D, Puello JJ, Zuccoli G, Seyfried T, Kadi ME. Metabolic treatment of cancer Anti-Aging Therapeutics - 2011 Conference Year. 119-126.  1
2011 Strelko CL, Lu W, Dufort FJ, Seyfried TN, Chiles TC, Rabinowitz JD, Roberts MF. Itaconic acid is a mammalian metabolite induced during macrophage activation. Journal of the American Chemical Society. 133: 16386-9. PMID 21919507 DOI: 10.1021/ja2070889  1
2011 Huysentruyt LC, Akgoc Z, Seyfried TN. Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme? Asn Neuro. 3. PMID 21834792 DOI: 10.1042/AN20110011  1
2011 Zhang L, Bell RJ, Kiebish MA, Seyfried TN, Han X, Gross RW, Chuang JH. A mathematical model for the determination of steady-state cardiolipin remodeling mechanisms using lipidomic data. Plos One. 6: e21170. PMID 21695174 DOI: 10.1371/journal.pone.0021170  1
2011 Arthur JR, Heinecke KA, Seyfried TN. Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain. Journal of Lipid Research. 52: 1345-51. PMID 21508255 DOI: 10.1194/jlr.M012633  1
2011 Mulrooney TJ, Marsh J, Urits I, Seyfried TN, Mukherjee P. Influence of caloric restriction on constitutive expression of NF-κB in an experimental mouse astrocytoma. Plos One. 6: e18085. PMID 21479220 DOI: 10.1371/journal.pone.0018085  1
2011 Seyfried TN. Biography of Dr. Robert K. Yu. Preface. Neurochemical Research. 36: 1575-7. PMID 21416119 DOI: 10.1007/s11064-011-0445-y  1
2011 Heinecke KA, Peacock BN, Blazar BR, Tolar J, Seyfried TN. Lipid composition of whole brain and cerebellum in Hurler syndrome (MPS IH) mice. Neurochemical Research. 36: 1669-76. PMID 21253856 DOI: 10.1007/s11064-011-0400-y  1
2011 Meidenbauer JJ, Mantis JG, Seyfried TN. The EL mouse: a natural model of autism and epilepsy. Epilepsia. 52: 347-57. PMID 21204822 DOI: 10.1111/j.1528-1167.2010.02898.x  1
2011 Seyfried TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P. Metabolic management of brain cancer. Biochimica Et Biophysica Acta. 1807: 577-94. PMID 20804725 DOI: 10.1016/j.bbabio.2010.08.009  1
2010 Baek RC, Broekman ML, Leroy SG, Tierney LA, Sandberg MA, d'Azzo A, Seyfried TN, Sena-Esteves M. AAV-mediated gene delivery in adult GM1-gangliosidosis mice corrects lysosomal storage in CNS and improves survival. Plos One. 5: e13468. PMID 20976108 DOI: 10.1371/journal.pone.0013468  1
2010 Huysentruyt LC, Seyfried TN. Perspectives on the mesenchymal origin of metastatic cancer. Cancer Metastasis Reviews. 29: 695-707. PMID 20839033 DOI: 10.1007/s10555-010-9254-z  1
2010 Denny CA, Desplats PA, Thomas EA, Seyfried TN. Cerebellar lipid differences between R6/1 transgenic mice and humans with Huntington's disease. Journal of Neurochemistry. 115: 748-58. PMID 20731757 DOI: 10.1111/j.1471-4159.2010.06964.x  1
2010 Shelton LM, Huysentruyt LC, Mukherjee P, Seyfried TN. Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse. Asn Neuro. 2: e00038. PMID 20664705 DOI: 10.1042/AN20100002  1
2010 Seyfried TN, Mukherjee P. Ganglioside GM3 Is Antiangiogenic in Malignant Brain Cancer. Journal of Oncology. 2010: 961243. PMID 20634908 DOI: 10.1155/2010/961243  1
2010 Seyfried TN, Shelton LM, Mukherjee P. Does the existing standard of care increase glioblastoma energy metabolism? The Lancet. Oncology. 11: 811-3. PMID 20634134 DOI: 10.1016/S1470-2045(10)70166-2  1
2010 Huang FJ, You WK, Bonaldo P, Seyfried TN, Pasquale EB, Stallcup WB. Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse. Developmental Biology. 344: 1035-46. PMID 20599895 DOI: 10.1016/j.ydbio.2010.06.023  1
2010 Shelton LM, Huysentruyt LC, Seyfried TN. Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model. International Journal of Cancer. Journal International Du Cancer. 127: 2478-85. PMID 20473919 DOI: 10.1002/ijc.25431  1
2010 Zuccoli G, Marcello N, Pisanello A, Servadei F, Vaccaro S, Mukherjee P, Seyfried TN. Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. Nutrition & Metabolism. 7: 33. PMID 20412570 DOI: 10.1186/1743-7075-7-33  1
2010 Kiebish MA, Bell R, Yang K, Phan T, Zhao Z, Ames W, Seyfried TN, Gross RW, Chuang JH, Han X. Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics. Journal of Lipid Research. 51: 2153-70. PMID 20410019 DOI: 10.1194/jlr.M004796  1
2010 Denny CA, Heinecke KA, Kim YP, Baek RC, Loh KS, Butters TD, Bronson RT, Platt FM, Seyfried TN. Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice. Journal of Neurochemistry. 113: 1525-35. PMID 20374428 DOI: 10.1111/j.1471-4159.2010.06733.x  1
2010 Seyfried TN, Shelton LM. Cancer as a metabolic disease. Nutrition & Metabolism. 7: 7. PMID 20181022 DOI: 10.1186/1743-7075-7-7  1
2010 Shelton LM, Mukherjee P, Huysentruyt LC, Urits I, Rosenberg JA, Seyfried TN. A novel pre-clinical in vivo mouse model for malignant brain tumor growth and invasion. Journal of Neuro-Oncology. 99: 165-76. PMID 20069342 DOI: 10.1007/s11060-010-0115-y  1
2010 Huysentruyt LC, Shelton LM, Seyfried TN. Influence of methotrexate and cisplatin on tumor progression and survival in the VM mouse model of systemic metastatic cancer. International Journal of Cancer. Journal International Du Cancer. 126: 65-72. PMID 19536778 DOI: 10.1002/ijc.24649  1
2010 Seyfried TN, Kiebish MA, Mukherjee P. Targeting energy metabolism in brain cancer with restricted diets Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies. 341-363. DOI: 10.1007/978-1-4419-0410-2_17  1
2009 Kiebish MA, Han X, Seyfried TN. Examination of the brain mitochondrial lipidome using shotgun lipidomics. Methods in Molecular Biology (Clifton, N.J.). 579: 3-18. PMID 19763468 DOI: 10.1007/978-1-60761-322-0_1  1
2009 Kiebish MA, Han X, Cheng H, Seyfried TN. In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours. Asn Neuro. 1. PMID 19570033 DOI: 10.1042/AN20090011  1
2009 Mantis JG, Fritz CL, Marsh J, Heinrichs SC, Seyfried TN. Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets. Epilepsy & Behavior : E&B. 15: 133-41. PMID 19249385 DOI: 10.1016/j.yebeh.2009.02.038  1
2009 Baek RC, Martin DR, Cox NR, Seyfried TN. Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease. Lipids. 44: 197-205. PMID 19034545 DOI: 10.1007/s11745-008-3268-0  1
2009 Seyfried TN, Heinecke KA, Mantis JG, Denny CA. Brain lipid analysis in mice with Rett syndrome. Neurochemical Research. 34: 1057-65. PMID 19002580 DOI: 10.1007/s11064-008-9874-7  1
2008 Seyfried TN, Kiebish M, Mukherjee P, Marsh J. Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets. Epilepsia. 49: 114-6. PMID 19049606 DOI: 10.1111/j.1528-1167.2008.01853.x  1
2008 Marsh J, Mukherjee P, Seyfried TN. Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7751-62. PMID 19047102 DOI: 10.1158/1078-0432.CCR-08-0213  1
2008 Marsh J, Mukherjee P, Seyfried TN. Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutrition & Metabolism. 5: 33. PMID 19032781 DOI: 10.1186/1743-7075-5-33  1
2008 Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN. Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. Journal of Lipid Research. 49: 2545-56. PMID 18703489 DOI: 10.1194/jlr.M800319-JLR200  1
2008 Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN. Brain mitochondrial lipid abnormalities in mice susceptible to spontaneous gliomas. Lipids. 43: 951-9. PMID 18560917 DOI: 10.1007/s11745-008-3197-y  1
2008 Mukherjee P, Mulrooney TJ, Marsh J, Blair D, Chiles TC, Seyfried TN. Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Molecular Cancer. 7: 37. PMID 18474106 DOI: 10.1186/1476-4598-7-37  1
2008 Huysentruyt LC, Mukherjee P, Banerjee D, Shelton LM, Seyfried TN. Metastatic cancer cells with macrophage properties: evidence from a new murine tumor model. International Journal of Cancer. Journal International Du Cancer. 123: 73-84. PMID 18398829 DOI: 10.1002/ijc.23492  1
2008 Kiebish MA, Han X, Cheng H, Lunceford A, Clarke CF, Moon H, Chuang JH, Seyfried TN. Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. Journal of Neurochemistry. 106: 299-312. PMID 18373617 DOI: 10.1111/j.1471-4159.2008.05383.x  0.8
2008 Mukherjee P, Faber AC, Shelton LM, Baek RC, Chiles TC, Seyfried TN. Thematic review series: sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. Journal of Lipid Research. 49: 929-38. PMID 18287616 DOI: 10.1194/jlr.R800006-JLR200  1
2008 Seyfried NT, Huysentruyt LC, Atwood JA, Xia Q, Seyfried TN, Orlando R. Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: a membrane proteomics approach. Cancer Letters. 263: 243-52. PMID 18281150 DOI: 10.1016/j.canlet.2008.01.007  1
2008 Prien JM, Huysentruyt LC, Ashline DJ, Lapadula AJ, Seyfried TN, Reinhold VN. Differentiating N-linked glycan structural isomers in metastatic and nonmetastatic tumor cells using sequential mass spectrometry. Glycobiology. 18: 353-66. PMID 18256178 DOI: 10.1093/glycob/cwn010  1
2008 Baek RC, Kasperzyk JL, Platt FM, Seyfried TN. N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice. Neurochemistry International. 52: 1125-33. PMID 18207611 DOI: 10.1016/j.neuint.2007.12.001  1
2007 McNally MA, Baek RC, Avila RL, Seyfried TN, Strichartz GR, Kirschner DA. Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis. Journal of Negative Results in Biomedicine. 6: 8. PMID 17623103 DOI: 10.1186/1477-5751-6-8  1
2007 Desplats PA, Denny CA, Kass KE, Gilmartin T, Head SR, Sutcliffe JG, Seyfried TN, Thomas EA. Glycolipid and ganglioside metabolism imbalances in Huntington's disease. Neurobiology of Disease. 27: 265-77. PMID 17600724 DOI: 10.1016/j.nbd.2007.05.003  1
2007 Denny CA, Alroy J, Pawlyk BS, Sandberg MA, d'Azzo A, Seyfried TN. Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice. Journal of Neurochemistry. 101: 1294-302. PMID 17442056 DOI: 10.1111/j.1471-4159.2007.04525.x  1
2007 Lee JP, Jeyakumar M, Gonzalez R, Takahashi H, Lee PJ, Baek RC, Clark D, Rose H, Fu G, Clarke J, McKercher S, Meerloo J, Muller FJ, Park KI, Butters TD, ... ... Seyfried TN, et al. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nature Medicine. 13: 439-47. PMID 17351625 DOI: 10.1038/nm1548  1
2007 Zhou W, Mukherjee P, Kiebish MA, Markis WT, Mantis JG, Seyfried TN. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutrition & Metabolism. 4: 5. PMID 17313687 DOI: 10.1186/1743-7075-4-5  1
2007 Broekman ML, Baek RC, Comer LA, Fernandez JL, Seyfried TN, Sena-Esteves M. Complete correction of enzymatic deficiency and neurochemistry in the GM1-gangliosidosis mouse brain by neonatal adeno-associated virus-mediated gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 30-7. PMID 17164772 DOI: 10.1038/sj.mt.6300004  1
2007 Todorova MT, Seyfried TN. Convulsive Disorders The Mouse in Biomedical Research. 3: 565-594. DOI: 10.1016/B978-012369454-6/50071-6  1
2007 Lee JP, Clark D, Jeyakumar M, Gonzalez R, McKercher S, Muller FJ, Jandial R, Taylor RM, In Park K, Seyfried TN, Platt FM, Snyder EY. Neural stem cell therapy in lysosomal storage disorders Lysosomal Storage Disorders. 197-216. DOI: 10.1007/978-0-387-70909-3_14  1
2006 Todorova MT, Mantis JG, Le M, Kim CY, Seyfried TN. Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice. Genes, Brain, and Behavior. 5: 518-27. PMID 17010098 DOI: 10.1111/j.1601-183X.2006.00204.x  1
2006 Abate LE, Mukherjee P, Seyfried TN. Gene-linked shift in ganglioside distribution influences growth and vascularity in a mouse astrocytoma. Journal of Neurochemistry. 98: 1973-84. PMID 16911584 DOI: 10.1111/j.1471-4159.2006.04097.x  1
2006 Mahoney LB, Denny CA, Seyfried TN. Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans. Lipids in Health and Disease. 5: 13. PMID 16709251 DOI: 10.1186/1476-511X-5-13  1
2006 Denny CA, Kasperzyk JL, Gorham KN, Bronson RT, Seyfried TN. Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice. Journal of Neuroscience Research. 83: 1028-38. PMID 16521125 DOI: 10.1002/jnr.20798  1
2006 Heinrichs SC, Seyfried TN. Behavioral seizure correlates in animal models of epilepsy: a road map for assay selection, data interpretation, and the search for causal mechanisms. Epilepsy & Behavior : E&B. 8: 5-38. PMID 16406351 DOI: 10.1016/j.yebeh.2005.08.009  1
2005 Seyfried TN, Mukherjee P. Targeting energy metabolism in brain cancer: review and hypothesis. Nutrition & Metabolism. 2: 30. PMID 16242042 DOI: 10.1186/1743-7075-2-30  1
2005 Kiebish MA, Seyfried TN. Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors. Bmc Cancer. 5: 102. PMID 16105171 DOI: 10.1186/1471-2407-5-102  1
2005 Kasperzyk JL, d'Azzo A, Platt FM, Alroy J, Seyfried TN. Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice. Journal of Lipid Research. 46: 744-51. PMID 15687347 DOI: 10.1194/jlr.M400411-JLR200  1
2004 Mantis JG, Centeno NA, Todorova MT, McGowan R, Seyfried TN. Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies. Nutrition & Metabolism. 1: 11. PMID 15507133 DOI: 10.1186/1743-7075-1-11  1
2004 Hauser EC, Kasperzyk JL, d'Azzo A, Seyfried TN. Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice. Biochemical Genetics. 42: 241-57. PMID 15487588 DOI: 10.1023/B:BIGI.0000034429.55418.71  1
2004 Mukherjee P, Abate LE, Seyfried TN. Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5622-9. PMID 15328205 DOI: 10.1158/1078-0432.CCR-04-0308  1
2004 Venit EL, Shepard BD, Seyfried TN. Oxygenation prevents sudden death in seizure-prone mice. Epilepsia. 45: 993-6. PMID 15270769 DOI: 10.1111/j.0013-9580.2004.02304.x  1
2004 Kasperzyk JL, El-Abbadi MM, Hauser EC, D'Azzo A, Platt FM, Seyfried TN. N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis. Journal of Neurochemistry. 89: 645-53. PMID 15086521 DOI: 10.1046/j.1471-4159.2004.02381.x  1
2003 Seyfried TN, Sanderson TM, El-Abbadi MM, McGowan R, Mukherjee P. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. British Journal of Cancer. 89: 1375-82. PMID 14520474 DOI: 10.1038/sj.bjc.6601269  1
2003 Greene AE, Todorova MT, Seyfried TN. Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies. Journal of Neurochemistry. 86: 529-37. PMID 12859666 DOI: 10.1046/j.1471-4159.2003.01862.x  1
2003 Todorova MT, Dangler CA, Drage MG, Sheppard BJ, Fox JG, Seyfried TN. Sexual dysfunction and sudden death in epileptic male EL mice: inheritance and prevention with the ketogenic diet. Epilepsia. 44: 25-31. PMID 12581226 DOI: 10.1046/j.1528-1157.2003.11402.x  1
2002 Drage MG, Holmes GL, Seyfried TN. Hippocampal neurons and glia in epileptic EL mice. Journal of Neurocytology. 31: 681-92. PMID 14501207 DOI: 10.1023/A:1025747813463  1
2002 Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN. Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. British Journal of Cancer. 86: 1615-21. PMID 12085212 DOI: 10.1038/sj.bjc.6600298  1
2001 Greene AE, Todorova MT, McGowan R, Seyfried TN. Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia. 42: 1371-8. PMID 11879337 DOI: 10.1046/j.1528-1157.2001.17601.x  1
2001 Liang D, Seyfried TN. Genes differentially expressed in the kindled mouse brain. Brain Research. Molecular Brain Research. 96: 94-102. PMID 11731014 DOI: 10.1016/S0169-328X(01)00287-X  1
2001 El-Abbadi M, Seyfried TN, Yates AJ, Orosz C, Lee MC. Ganglioside composition and histology of a spontaneous metastatic brain tumour in the VM mouse. British Journal of Cancer. 85: 285-92. PMID 11461091 DOI: 10.1054/bjoc.2001.1909  1
2001 Seyfried TN. Perspectives on brain tumor formation involving macrophages, glia, and neural stem cells. Perspectives in Biology and Medicine. 44: 263-82. PMID 11370160  1
2001 Ranes MK, El-Abbadi M, Manfredi MG, Mukherjee P, Platt FM, Seyfried TN. N -butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours. British Journal of Cancer. 84: 1107-14. PMID 11308262 DOI: 10.1054/bjoc.2000.1713  1
2000 Todorova MT, Tandon P, Madore RA, Stafstrom CE, Seyfried TN. The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy. Epilepsia. 41: 933-40. PMID 10961617  1
1999 Todorova MT, Burwell TJ, Seyfried TN. Environmental risk factors for multifactorial epilepsy in EL mice. Epilepsia. 40: 1697-707. PMID 10612332  1
1999 Manfredi MG, Lim S, Claffey KP, Seyfried TN. Gangliosides influence angiogenesis in an experimental mouse brain tumor. Cancer Research. 59: 5392-7. PMID 10537325  1
1999 Seyfried TN, Todorova MT, Poderycki MJ. Experimental models of multifactorial epilepsies: the EL mouse and mice susceptible to audiogenic seizures. Advances in Neurology. 79: 279-90. PMID 10514820  1
1999 Ecsedy JA, Holthaus KA, Yohe HC, Seyfried TN. Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice. Journal of Neurochemistry. 73: 254-9. PMID 10386978 DOI: 10.1046/j.1471-4159.1999.0730254.x  1
1998 DiRocco L, Dalton T, Liang D, Nebert DW, Seyfried TN. Nonallelism for the audiogenic seizure prone (Asp1) and the aryl hydrocarbon receptor (Ahr) loci in mice. Journal of Neurogenetics. 12: 191-203. PMID 10656108  1
1998 Poderycki MJ, Simoes JM, Todorova MT, Neumann PE, Seyfried TN. Environmental influences on epilepsy gene mapping in EL mice. Journal of Neurogenetics. 12: 67-86. PMID 10197158  1
1998 Ecsedy JA, Yohe HC, Bergeron AJ, Seyfried TN. Tumor-infiltrating macrophages influence the glycosphingolipid composition of murine brain tumors. Journal of Lipid Research. 39: 2218-27. PMID 9799808  1
1998 Brigande JV, Seyfried TN. Glycosphingolipid biosynthesis may not be necessary for vertebrate brain development. Annals of the New York Academy of Sciences. 845: 215-8. PMID 9668354 DOI: 10.1111/j.1749-6632.1998.tb09673.x  1
1998 Seyfried TN, el-Abbadi M, Ecsedy JA, Griffin ME, Yohe HC. Ganglioside composition of a mouse brain tumor grown in the severe combined immunodeficiency (SCID) mouse. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 33: 27-37. PMID 9493174  1
1998 Brigande JV, Platt FM, Seyfried TN. Inhibition of glycosphingolipid biosynthesis does not impair growth or morphogenesis of the postimplantation mouse embryo. Journal of Neurochemistry. 70: 871-82. PMID 9453585  1
1997 Banko ML, Allen KM, Dolina S, Neumann PE, Seyfried TN. Genomic imprinting and audiogenic seizures in mice. Behavior Genetics. 27: 465-75. PMID 9336083 DOI: 10.1023/A:1025626501148  1
1997 Lewis SM, Lee FS, Todorova M, Seyfried TN, Ueda T. Synaptic vesicle glutamate uptake in epileptic (EL) mice. Neurochemistry International. 31: 581-5. PMID 9308008 DOI: 10.1016/S0197-0186(97)00014-4  1
1997 Ecsedy JA, Manfredi MG, Yohe HC, Seyfried TN. Ganglioside biosynthetic gene expression in experimental mouse brain tumors. Cancer Research. 57: 1580-3. PMID 9108463  1
1997 Bai H, Seyfried TN. Influence of ganglioside GM3 and high density lipoprotein on the cohesion of mouse brain tumor cells. Journal of Lipid Research. 38: 160-72. PMID 9034210  1
1996 Seyfried TN, el-Abbadi M, Ecsedy JA, Bai HW, Yohe HC. Influence of host cell infiltration on the glycolipid content of mouse brain tumors. Journal of Neurochemistry. 66: 2026-33. PMID 8780032  1
1995 Garey CE, Schwarzman AL, Rise ML, Seyfried TN. Ceruloplasmin gene defect associated with epilepsy in EL mice. Nature Genetics. 11: 104. PMID 7550304 DOI: 10.1038/ng0995-104f  1
1994 Cotterchio M, Seyfried TN. Serum gangliosides in mice with metastatic and non-metastatic brain tumors. Journal of Lipid Research. 35: 10-4. PMID 8138710  1
1994 el-Abbadi M, Seyfried TN. Influence of growth environment on the ganglioside composition of an experimental mouse brain tumor. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 21: 273-85. PMID 8086038 DOI: 10.1007/BF02815355  1
1994 Seyfried TN, Novikov AM, Irvine RA, Brigande JV. Ganglioside biosynthesis in mouse embryos: sialyltransferase IV and the asialo pathway. Journal of Lipid Research. 35: 993-1001. PMID 8077855  1
1994 Allen KM, Seyfried TN. Genetic analysis of nucleotide triphosphatase activity in the mouse brain. Genetics. 137: 257-65. PMID 8056315  1
1994 Garey CE, Schwarzman AL, Rise ML, Seyfried TN. Ceruloplasmin gene defect associated with epilepsy in EL mice. Nature Genetics. 6: 426-31. PMID 7914452 DOI: 10.1038/ng0494-426  1
1994 Flavin HJ, Seyfried TN. Enhanced aspartate release related to epilepsy in (EL) mice. Journal of Neurochemistry. 63: 592-5. PMID 7913488  1
1994 Irvine RA, Seyfried TN. Phylogenetic conservation of ganglioside GD3 expression during early vertebrate ontogeny. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 109: 603-12. PMID 7881823 DOI: 10.1016/0305-0491(94)90123-6  1
1994 Kadowaki H, Grant MA, Seyfried TN. Effect of Golgi membrane phospholipid composition on the molecular species of GM3 gangliosides synthesized by rat liver sialyltransferase. Journal of Lipid Research. 35: 1956-64. PMID 7868974  1
1993 Cotterchio M, Seyfried TN. The influence of ImuVert, a biological response modifier, on the growth and ganglioside composition of murine neural tumors. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 20: 163-72. PMID 8297420 DOI: 10.1007/BF02815369  1
1993 Wieraszko A, Seyfried TN. Influence of audiogenic seizures on synaptic facilitation in mouse hippocampal slices is mediated by N-methyl-D-aspartate receptor. Epilepsia. 34: 979-84. PMID 7902271 DOI: 10.1111/j.1528-1157.1993.tb02122.x  1
1992 Brigande JV, Wieraszko A, Albert MD, Balkema GW, Seyfried TN. Biochemical correlates of epilepsy in the E1 mouse: analysis of glial fibrillary acidic protein and gangliosides. Journal of Neurochemistry. 58: 752-60. PMID 1729417 DOI: 10.1111/j.1471-4159.1992.tb09782.x  1
1992 Seyfried TN, el-Abbadi M, Roy ML. Ganglioside distribution in murine neural tumors. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 17: 147-67. PMID 1418222 DOI: 10.1007/BF03159989  1
1992 Bai H, Orlando J, Seyfried TN. Altered ganglioside composition in virally transformed rat embryo fibroblasts. Biochimica Et Biophysica Acta. 1136: 23-7. PMID 1322707 DOI: 10.1016/0167-4889(92)90080-U  1
1992 Seyfried TN, Ariga T. Neutral glycolipid abnormalities in a t-complex mutant mouse embryo. Biochemical Genetics. 30: 557-65. PMID 1296571 DOI: 10.1007/PL00020517  1
1991 Green RC, Seyfried TN. Kindling susceptibility and genetic seizure predisposition in inbred mice. Epilepsia. 32: 22-6. PMID 1985826  1
1991 Rise ML, Frankel WN, Coffin JM, Seyfried TN. Genes for epilepsy mapped in the mouse. Science (New York, N.Y.). 253: 669-73. PMID 1871601  1
1991 Novikov AM, Seyfried TN. Ganglioside GD3 biosynthesis in normal and mutant mouse embryos. Biochemical Genetics. 29: 627-38. PMID 1820026 DOI: 10.1007/BF00554135  1
1991 Flavin HJ, Wieraszko A, Seyfried TN. Enhanced aspartate release from hippocampal slices of epileptic (El) mice. Journal of Neurochemistry. 56: 1007-11. PMID 1671582  1
1990 Seyfried TN, Yu RK. Cerebellar ganglioside abnormalities in pcd mutant mice. Journal of Neuroscience Research. 26: 105-11. PMID 2359143 DOI: 10.1002/jnr.490260113  1
1990 Neumann PE, Seyfried TN. Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice. Behavior Genetics. 20: 307-23. PMID 2141254 DOI: 10.1007/BF01067798  1
1990 Bouvier JD, Seyfried TN. Ganglioside GM1 elevation in DBA/2 mouse embryos. Developmental Neuroscience. 12: 126-32. PMID 2110523 DOI: 10.1159/000111841  1
1990 Wieraszko A, Seyfried TN. Involvement of ATP as a neurotransmitter in the hippocampus Annals of the New York Academy of Sciences. 603: 494-496. DOI: 10.1111/j.1749-6632.1990.tb37717.x  1
1989 Bouvier JD, Seyfried TN. Ganglioside composition of normal and mutant mouse embryos. Journal of Neurochemistry. 52: 460-6. PMID 2911026  1
1989 Wieraszko A, Seyfried TN. ATP-induced synaptic potentiation in hippocampal slices. Brain Research. 491: 356-9. PMID 2765890 DOI: 10.1016/0006-8993(89)90070-X  1
1989 Wieraszko A, Goldsmith G, Seyfried TN. Stimulation-dependent release of adenosine triphosphate from hippocampal slices. Brain Research. 485: 244-50. PMID 2566360 DOI: 10.1016/0006-8993(89)90567-2  1
1989 Wieraszko A, Seyfried TN. Increased amount of extracellular ATP in stimulated hippocampal slices of seizure prone mice. Neuroscience Letters. 106: 287-93. PMID 2532311 DOI: 10.1016/0304-3940(89)90178-X  1
1988 Palayoor ST, Seyfried TN. Brain cationic ATPase activities in epileptic (El) mice. Experimental Neurology. 99: 768-71. PMID 2830130 DOI: 10.1016/0014-4886(88)90191-4  1
1987 Seyfried TN. Ganglioside abnormalities associated with failed neural differentiation in a T-locus mutant mouse embryo. Developmental Biology. 123: 286-91. PMID 3622933 DOI: 10.1016/0012-1606(87)90451-9  1
1987 Seyfried TN, Bernard DJ, Yu RK. Effect of Purkinje cell loss on cerebellar gangliosides in nervous mutant mice. Journal of Neuroscience Research. 17: 251-5. PMID 3599097 DOI: 10.1002/jnr.490170308  1
1987 Seyfried TN, Yu RK, Saito M, Albert M. Ganglioside composition of an experimental mouse brain tumor. Cancer Research. 47: 3538-42. PMID 3581087  1
1986 Seyfried TN, Glaser GH, Yu RK, Palayoor ST. Inherited convulsive disorders in mice. Advances in Neurology. 44: 115-33. PMID 3518345  1
1986 Palayoor ST, Seyfried TN, Bernard DJ. Calcium ATPase activities in synaptic plasma membranes of seizure-prone mice. Journal of Neurochemistry. 46: 1370-5. PMID 2937883  1
1986 LeVine SM, Seyfried TN, Yu RK, Goldman JE. Immunocytochemical localization of GD3 ganglioside to astrocytes in murine cerebellar mutants. Brain Research. 374: 260-9. PMID 2424561 DOI: 10.1016/0006-8993(86)90420-8  1
1986 Miskimins R, Ebato H, Seyfried TN, Yu RK. Molecular basis for heterosis for myelin basic protein content in mice. Proceedings of the National Academy of Sciences of the United States of America. 83: 1532-5. PMID 2419910  1
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