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Wendy T. Watford, Ph.D. - Publications

Affiliations: 
2001 Duke University, Durham, NC 
Area:
Immunology, Cell Biology, Animal Physiology Biology
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Latha K, Patel Y, Rao S, Watford WT. The Influenza-Induced Pulmonary Inflammatory Exudate in Susceptible Tpl2-Deficient Mice Is Dictated by Type I IFN Signaling. Inflammation. PMID 36227523 DOI: 10.1007/s10753-022-01736-8  0.329
2017 Acuff NV, Li X, Latha K, Nagy T, Watford WT. Tpl2 promotes innate cell recruitment and effector T cell differentiation to limit Citrobacter rodentium burden and dissemination. Infection and Immunity. PMID 28760932 DOI: 10.1128/Iai.00193-17  0.378
2016 Li X, Acuff NV, Peeks AR, Kirkland R, Wyatt KD, Nagy T, Watford WT. Tumor Progression Locus 2 (Tpl2) Activates the MTOR Pathway, Inhibits FoxP3 Expression and Limits Treg Immunosuppressive Functions. The Journal of Biological Chemistry. PMID 27261457 DOI: 10.1074/Jbc.M116.718783  0.354
2015 Acuff NV, Li X, Kirkland R, Nagy T, Watford WT. Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitis. Plos One. 10: e0119885. PMID 25781948 DOI: 10.1371/Journal.Pone.0119885  0.35
2014 Oksanen A, Aittomäki S, Jankovic D, Ortutay Z, Pulkkinen K, Hämäläinen S, Rokka A, Corthals GL, Watford WT, Junttila I, O'Shea JJ, Pesu M. Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii Journal of Immunology. 193: 5470-5479. PMID 25355923 DOI: 10.4049/jimmunol.1401629  0.376
2012 Gil MP, Ploquin MJ, Watford WT, Lee SH, Kim K, Wang X, Kanno Y, O'Shea JJ, Biron CA. Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function. Blood. 120: 3718-28. PMID 22968462 DOI: 10.1182/Blood-2012-05-428672  0.417
2010 Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature. 467: 967-71. PMID 20962846 DOI: 10.1038/Nature09447  0.376
2010 Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity. 32: 840-51. PMID 20620946 DOI: 10.1016/J.Immuni.2010.06.003  0.397
2010 Durant L, Watford WT, Ramos HL, Laurence A, Vahedi G, Wei L, Takahashi H, Sun HW, Kanno Y, Powrie F, O'Shea JJ. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 32: 605-15. PMID 20493732 DOI: 10.1016/J.Immuni.2010.05.003  0.421
2010 Olivera A, Eisner C, Kitamura Y, Dillahunt S, Allende L, Tuymetova G, Watford W, Meylan F, Diesner SC, Li L, Schnermann J, Proia RL, Rivera J. Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. The Journal of Clinical Investigation. 120: 1429-40. PMID 20407207 DOI: 10.1172/Jci40659  0.361
2010 Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN. Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. Journal of Immunology (Baltimore, Md. : 1950). 184: 105-13. PMID 19955521 DOI: 10.4049/Jimmunol.0803730  0.464
2009 Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production. Journal of Immunology (Baltimore, Md. : 1950). 183: 7984-93. PMID 19933865 DOI: 10.4049/Jimmunol.0901336  0.424
2009 Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 30: 875-87. PMID 19501000 DOI: 10.1016/J.Immuni.2009.05.005  0.402
2009 O'Shea JJ, Steward-Tharp SM, Laurence A, Watford WT, Wei L, Adamson AS, Fan S. Signal transduction and Th17 cell differentiation. Microbes and Infection. 11: 599-611. PMID 19379825 DOI: 10.1016/J.Micinf.2009.04.007  0.422
2009 Charles N, Watford WT, Ramos HL, Hellman L, Oettgen HC, Gomez G, Ryan JJ, O'Shea JJ, Rivera J. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity. 30: 533-43. PMID 19362019 DOI: 10.1016/J.Immuni.2009.02.008  0.413
2009 Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity. 30: 155-67. PMID 19144320 DOI: 10.1016/J.Immuni.2008.12.009  0.405
2009 Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. The Journal of Experimental Medicine. 206: 35-41. PMID 19114665 DOI: 10.1084/Jem.20072713  0.409
2009 Brydges S, Mueller J, McGeough M, Pena C, Misaghi A, Gandhi C, Boyle D, Firestein G, Horner A, Soroosh P, Putnam C, Watford W, O'Shea J, Kastner D, Hoffman H. OR.26. Animal Models of Inflammasomapathy Solely Implicate the Innate Immune System in Pathogenesis, with an Important but not Universal Role for IL-1β Clinical Immunology. 131: S13-S14. DOI: 10.1016/J.Clim.2009.03.033  0.335
2008 Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, et al. Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. The Journal of Experimental Medicine. 205: 2803-12. PMID 19001140 DOI: 10.1084/Jem.20081461  0.468
2008 Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nature Immunology. 9: 1279-87. PMID 18806793 DOI: 10.1038/Ni.1653  0.431
2008 Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, O'Shea JJ. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature. 455: 246-50. PMID 18701887 DOI: 10.1038/Nature07210  0.409
2008 Laurence A, O'Shea JJ, Watford WT. Interleukin-22: a sheep in wolf's clothing. Nature Medicine. 14: 247-9. PMID 18323844 DOI: 10.1038/Nm0308-247  0.334
2008 Foulds KE, Rotte MJ, Paley MA, Singh B, Douek DC, Hill BJ, O'Shea JJ, Watford WT, Seder RA, Wu CY. IFN-gamma mediates the death of Th1 cells in a paracrine manner. Journal of Immunology (Baltimore, Md. : 1950). 180: 842-9. PMID 18178823 DOI: 10.4049/Jimmunol.180.2.842  0.404
2008 Mielke LA, Elkins K, Starr R, Hilton DJ, Tsichlis P, O’Shea JJ, Watford WT. 298 Receptor and cell-specific function of MAP3K8/TPL2 in innate immune signaling and cytokine production Cytokine. 43: 314. DOI: 10.1016/J.Cyto.2008.07.381  0.362
2007 Ramos HL, O'Shea JJ, Watford WT. STAT5 isoforms: controversies and clarifications. The Biochemical Journal. 404: e1-2. PMID 17447893 DOI: 10.1042/Bj2007420  0.355
2007 Li H, Watford W, Li C, Parmelee A, Bryant MA, Deng C, O'Shea J, Lee SB. Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. The Journal of Clinical Investigation. 117: 1314-23. PMID 17415412 DOI: 10.1172/Jci31222  0.352
2007 Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, Watford WT, Laurence A, Robinson GW, Shevach EM, Moriggl R, Hennighausen L, Wu C, O'Shea JJ. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood. 109: 4368-75. PMID 17227828 DOI: 10.1182/Blood-2006-11-055756  0.414
2006 Watford WT, Li D, Agnello D, Durant L, Yamaoka K, Yao ZJ, Ahn HJ, Cheng TP, Hofmann SR, Cogliati T, Chen A, Hissong BD, Husa MR, Schwartzberg P, O'Shea JJ, et al. Cytohesin binder and regulator (cybr) is not essential for T- and dendritic-cell activation and differentiation. Molecular and Cellular Biology. 26: 6623-32. PMID 16914744 DOI: 10.1128/Mcb.02460-05  0.421
2006 Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ. Stat5a/b are essential for normal lymphoid development and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 103: 1000-5. PMID 16418296 DOI: 10.1073/Pnas.0507350103  0.441
2004 Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O'Shea JJ. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunological Reviews. 202: 139-56. PMID 15546391 DOI: 10.1111/J.0105-2896.2004.00211.X  0.366
2004 O'Shea JJ, Watford W. A peek at PIAS. Nature Immunology. 5: 875-6. PMID 15334080 DOI: 10.1038/Ni0904-875  0.314
2004 O'Shea JJ, Husa M, Li D, Hofmann SR, Watford W, Roberts JL, Buckley RH, Changelian P, Candotti F. Jak3 and the pathogenesis of severe combined immunodeficiency. Molecular Immunology. 41: 727-37. PMID 15220007 DOI: 10.1016/J.Molimm.2004.04.014  0.354
2003 Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine & Growth Factor Reviews. 14: 361-8. PMID 12948519 DOI: 10.1016/S1359-6101(03)00043-1  0.447
2002 Watford WT, Smithers MB, Frank MM, Wright JR. Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283: L1011-22. PMID 12376354 DOI: 10.1152/Ajplung.00366.2001  0.542
2002 Nguyen KB, Watford WT, Salomon R, Hofmann SR, Pien GC, Morinobu A, Gadina M, O'Shea JJ, Biron CA. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science (New York, N.Y.). 297: 2063-6. PMID 12242445 DOI: 10.1126/Science.1074900  0.371
2002 Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M. Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 2625-9. PMID 11867758 DOI: 10.1073/Pnas.052712999  0.416
2001 Watford WT, Wright JR, Hester CG, Jiang H, Frank MM. Surfactant protein A regulates complement activation. Journal of Immunology (Baltimore, Md. : 1950). 167: 6593-600. PMID 11714829 DOI: 10.4049/Jimmunol.167.11.6593  0.54
1999 LeVine AM, Kurak KE, Wright JR, Watford WT, Bruno MD, Ross GF, Whitsett JA, Korfhagen TR. Surfactant protein-A binds group B streptococcus enhancing phagocytosis and clearance from lungs of surfactant protein-A-deficient mice. American Journal of Respiratory Cell and Molecular Biology. 20: 279-86. PMID 9922219 DOI: 10.1165/Ajrcmb.20.2.3303  0.547
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