Carlos Cruchaga - Related publications

Washington University School of Medicine, St. Louis, MO, United States 
Alzheimer's, genetics, genomics, quantitative traits, WES, WGS, proteomics
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Cardona K, Medina J, Orrego-Cardozo M, Restrepo de Mejía F, Elcoroaristizabal X, Naranjo Galvis CA. Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer's disease reveals key pathways and hub genes with potential diagnostic utility: a preliminary study. Peerj. 9: e12016. PMID 34484988 DOI: 10.7717/peerj.12016   
2021 Pyun JM, Park YH, Lee KJ, Kim S, Saykin AJ, Nho K, . Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment. Translational Neurodegeneration. 10: 32. PMID 34465370 DOI: 10.1186/s40035-021-00259-w   
2021 Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, ... , et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease. Nature Genetics. 53: 1276-1282. PMID 34493870 DOI: 10.1038/s41588-021-00921-z   
2021 Luo R, Fan Y, Yang J, Ye M, Zhang DF, Guo K, Li X, Bi R, Xu M, Yang LX, Li Y, Ran X, Jiang HY, Zhang C, Tan L, et al. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. Signal Transduction and Targeted Therapy. 6: 325. PMID 34465723 DOI: 10.1038/s41392-021-00748-4   
2021 Xiao X, Guo L, Liao X, Zhou Y, Zhang W, Zhou L, Wang X, Liu X, Liu H, Xu T, Zhu Y, Yang Q, Hao X, Liu Y, Wang J, et al. The role of vascular dementia associated genes in patients with Alzheimer's disease: A large case-control study in the Chinese population. Cns Neuroscience & Therapeutics. PMID 34551193 DOI: 10.1111/cns.13730   
2021 Ghosh P, Singh R, Ganeshpurkar A, Pokle AV, Singh RB, Singh SK, Kumar A. Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts & roles. Neurochemistry International. 151: 105212. PMID 34656693 DOI: 10.1016/j.neuint.2021.105212   
2021 Wang H, Zhang Y, Zheng C, Yang S, Chen X, Wang H, Gao S. A 3-Gene-Based Diagnostic Signature in Alzheimer's Disease. European Neurology. 1-8. PMID 34521086 DOI: 10.1159/000518727   
2021 D'Andrea L, Stringhi R, Di Luca M, Marcello E. Looking at Alzheimer's Disease Pathogenesis from the Nuclear Side. Biomolecules. 11. PMID 34572474 DOI: 10.3390/biom11091261   
2021 Li K, Fu Z, Qi S, Luo X, Zeng Q, Xu X, Huang P, Zhang M, Calhoun VD. Polygenic Hazard Score Associated Multimodal Brain Networks Along the Alzheimer's Disease Continuum. Frontiers in Aging Neuroscience. 13: 725246. PMID 34539385 DOI: 10.3389/fnagi.2021.725246   
2021 Uddin MS, Kabir MT, Jalouli M, Rahman MA, Jeandet P, Behl T, Alexiou A, Albadrani GM, Abdel-Daim MM, Perveen A, Ashraf GM. Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease. Current Neuropharmacology. PMID 34525932 DOI: 10.2174/1570159X19666210826130210   
2021 Wei X, Xie L, Du P, Zhao Z. Impacts of DNA methylation on Tau protein related genes in the brains of patients with Alzheimer's Disease. Neuroscience Letters. 136196. PMID 34437990 DOI: 10.1016/j.neulet.2021.136196   
2021 Ibanez L, Cruchaga C, Fernández MV. Advances in Genetic and Molecular Understanding of Alzheimer's Disease. Genes. 12. PMID 34440421 DOI: 10.3390/genes12081247   
2021 Möllers T, Stocker H, Perna L, Nabers A, Rujescu D, Hartmann AM, Holleczek B, Schöttker B, Gerwert K, Brenner H. Aβ misfolding in blood plasma is inversely associated with body mass index even in middle adulthood. Alzheimer's Research & Therapy. 13: 145. PMID 34461995 DOI: 10.1186/s13195-021-00889-2   
2021 Han S, Na Y, Koh I, Nho K, Lee Y. Alternative Splicing Regulation of Low-Frequency Genetic Variants in Exon 2 of in Alzheimer's Disease by Splicing-Based Aggregation. International Journal of Molecular Sciences. 22. PMID 34576031 DOI: 10.3390/ijms22189865   
2021 Kaur D, Behl T, Chigurupati S, Sehgal A, Singh S, Sharma N, Badavath VN, Vargas-De-La-Cruz C, Bhatia S, Al-Harrasi A, Dey A, Aleya L, Bungau S. Deciphering the focal role of endostatin in Alzheimer's disease. Environmental Science and Pollution Research International. PMID 34561808 DOI: 10.1007/s11356-021-16567-7   
2021 Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW, . Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34647694 DOI: 10.1002/alz.12480   
2021 Avitan I, Halperin Y, Saha T, Bloch N, Atrahimovich D, Polis B, Samson AO, Braitbard O. Towards a Consensus on Alzheimer's Disease Comorbidity? Journal of Clinical Medicine. 10. PMID 34640387 DOI: 10.3390/jcm10194360   
2021 Chong JR, Ashton NJ, Karikari TK, Tanaka T, Schöll M, Zetterberg H, Blennow K, Chen CP, Lai MKP. Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 34510001 DOI: 10.1136/jnnp-2021-327370   
2021 Tsai HH, Chen YF, Yen RF, Lo YL, Yang KC, Jeng JS, Tsai LK, Chang CF. Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau. Brain : a Journal of Neurology. PMID 34515756 DOI: 10.1093/brain/awab332   
2021 Tan MS, Cheah PL, Chin AV, Looi LM, Chang SW. A review on omics-based biomarkers discovery for Alzheimer's disease from the bioinformatics perspectives: Statistical approach vs machine learning approach. Computers in Biology and Medicine. 139: 104947. PMID 34678481 DOI: 10.1016/j.compbiomed.2021.104947   
2021 Huang W, Bartosch AM, Xiao H, Maji S, Youth EHH, Flowers X, Leskinen S, Tomljanovic Z, Iodice G, Boyett D, Spinazzi E, Menon V, McGovern RA, McKhann GM, Teich AF. An immune response characterizes early Alzheimer's disease pathology and subjective cognitive impairment in hydrocephalus biopsies. Nature Communications. 12: 5659. PMID 34580300 DOI: 10.1038/s41467-021-25902-y   
2021 Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Van Skike CE, Galvan V, Dupree JL, Han X. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment. Molecular Neurodegeneration. 16: 64. PMID 34526055 DOI: 10.1186/s13024-021-00488-7   
2021 Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y. Current Alzheimer disease research highlights: evidence for novel risk factors. Chinese Medical Journal. PMID 34507318 DOI: 10.1097/CM9.0000000000001706   
2021 Setti SE, Reed MN. Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. Metabolic Brain Disease. PMID 34591222 DOI: 10.1007/s11011-021-00848-8   
2021 Wu ATH, Lawal B, Wei L, Wen YT, Tzeng DTW, Lo WC. Multiomics Identification of Potential Targets for Alzheimer Disease and Antrocin as a Therapeutic Candidate. Pharmaceutics. 13. PMID 34683848 DOI: 10.3390/pharmaceutics13101555   
2021 Mahdiabadi S, Momtazmanesh S, Perry G, Rezaei N. Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review. Reviews in the Neurosciences. PMID 34506700 DOI: 10.1515/revneuro-2021-0092   
2021 Kim GH, Lee YC, Kim TJ, Kim ER, Hong SN, Chang DK, Kim YH. Risk of neurodegenerative diseases in patients with inflammatory bowel disease: a nationwide population-based cohort study. Journal of Crohn's & Colitis. PMID 34499125 DOI: 10.1093/ecco-jcc/jjab162   
2021 Kloske CM, Dugan AJ, Weekman EM, Winder Z, Patel E, Nelson PT, Fardo DW, Wilcock DM. Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status. Journal of Neuropathology and Experimental Neurology. PMID 34486652 DOI: 10.1093/jnen/nlab085   
2021 Xiromerisiou G, Bourinaris T, Houlden H, Lewis PA, Senkevich K, Hammer M, Federoff M, Khan A, Spanaki C, Hadjigeorgiou GM, Bonstanjopoulou S, Fidani L, Ermolaev A, Gan-Or Z, Singleton A, et al. SORL1 mutation in a Greek family with Parkinson's disease and dementia. Annals of Clinical and Translational Neurology. PMID 34506082 DOI: 10.1002/acn3.51433   
2021 Tijms BM, Gobom J, Teunissen C, Dobricic V, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuévo JL, Engelborghs S, Freund-Levi Y, Froelich L, Bertram L, et al. CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals. Proteomes. 9. PMID 34449748 DOI: 10.3390/proteomes9030036   
2021 Wang RZ, Yang YX, Li HQ, Shen XN, Chen SD, Cui M, Wang Y, Dong Q, Yu JT. Genetically determined low income modifies Alzheimer's disease risk. Annals of Translational Medicine. 9: 1222. PMID 34532359 DOI: 10.21037/atm-21-344   
2021 Ebenau JL, van der Lee SJ, Hulsman M, Tesi N, Jansen IE, Verberk IMW, van Leeuwenstijn M, Teunissen CE, Barkhof F, Prins ND, Scheltens P, Holstege H, van Berckel BNM, van der Flier WM. Risk of dementia in ε4 carriers is mitigated by a polygenic risk score. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12229. PMID 34541285 DOI: 10.1002/dad2.12229   
2021 Wang M, Lv J, Huang X, Wisniewski T, Zhang W. High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer's disease associated with chronic platelet activation. Alzheimer's Research & Therapy. 13: 144. PMID 34454596 DOI: 10.1186/s13195-021-00890-9   
2021 Xu X, Zhang B, Wang X, Zhang Q, Wu X, Zhang J, Bai Y, Gu X. A meta-analysis of Alzheimer's disease's relationship with human ApoE gene variants. American Journal of Translational Research. 13: 9974-9982. PMID 34650676   
2021 Sharma A, Anand JS, Kumar Y. Immunotherapeutics for AD: A Work in Progress. Cns & Neurological Disorders Drug Targets. PMID 34477533 DOI: 10.2174/1871527320666210903101522   
2021 Chen SD, Lu JY, Li HQ, Yang YX, Jiang JH, Cui M, Zuo CT, Tan L, Dong Q, Yu JT, . Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study. Translational Psychiatry. 11: 483. PMID 34537810 DOI: 10.1038/s41398-021-01602-5   
2021 Dong L, Li J, Liu C, Mao C, Wang J, Lei D, Huang X, Chu S, Hou B, Feng F, Sha L, Xu Q, Gao J. Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort. Brain and Behavior. e2373. PMID 34555265 DOI: 10.1002/brb3.2373   
2021 Hall JR, Johnson LA, Zhang F, Petersen M, Toga AW, Shi Y, Mason D, Rissman RA, Yaffe K, O'Bryant SE, . Using Fractional Anisotropy Imaging to Detect Mild Cognitive Impairment and Alzheimer's Disease among Mexican Americans and Non-Hispanic Whites: A HABLE Study. Dementia and Geriatric Cognitive Disorders. 1-8. PMID 34569492 DOI: 10.1159/000518102   
2021 Li S, Wang C, Wang Z, Tan J. Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer's disease: an adrenergic approach. Aging. 13. PMID 34479211 DOI: 10.18632/aging.203482   
2021 Chen J, Li Q, Zhu J, Yuan Z, Wang T, Song J. GPR40 Agonist Ameliorate Pathological Neuroinflammation of Alzheimer's Disease via the Modulation of Gut Microbiota and Immune System, a Mini-Review. Neurotoxicity Research. PMID 34505972 DOI: 10.1007/s12640-021-00408-z   
2021 Kim DH, Han GS. The relationship between periodontal disease and cognitive impairment in older adults of Korea. Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry For the Handicapped, and the American Society For Geriatric Dentistry. PMID 34614224 DOI: 10.1111/scd.12657   
2021 Terracciano A, Bilgel M, Aschwanden D, Luchetti M, Stephan Y, Moghekar AR, Wong DF, Ferrucci L, Sutin AR, Resnick SM. Personality Associations With Amyloid and Tau: Results From the Baltimore Longitudinal Study of Aging and Meta-analysis. Biological Psychiatry. PMID 34663503 DOI: 10.1016/j.biopsych.2021.08.021   
2021 Wang F, Xu CS, Chen WH, Duan SW, Xu SJ, Dai JJ, Wang QW. Identification of Blood-Based Glycolysis Gene Associated with Alzheimer's Disease by Integrated Bioinformatics Analysis. Journal of Alzheimer's Disease : Jad. PMID 34308907 DOI: 10.3233/JAD-210540   
2021 Kim JP, Kim BH, Bice PJ, Seo SW, Bennett DA, Saykin AJ, Nho K, . BMI1 is associated with CS8F amyloid-β and rates of cognitive decline in Alzheimer's disease. Alzheimer's Research & Therapy. 13: 164. PMID 34610832 DOI: 10.1186/s13195-021-00906-4   
2021 Rather MA, Khan A, Alshahrani S, Rashid H, Qadri M, Rashid S, Alsaffar RM, Kamal MA, Rehman MU. Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products. Mediators of Inflammation. 2021: 9982954. PMID 34381308 DOI: 10.1155/2021/9982954   
2021 Jutten RJ, Sikkes SAM, Van der Flier WM, Scheltens P, Visser PJ, Tijms BM, . Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity. Neurology. 96: e2673-e2684. PMID 34550903 DOI: 10.1212/WNL.0000000000012022   
2021 Zhang J, Tan H, Cao Q, Su G, Yang P. Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease. Disease Markers. 2021: 9978460. PMID 34659590 DOI: 10.1155/2021/9978460   
2021 Zhang Z, Wang M, Yuan S, Cai H, Zhu SG, Liu X. Genetically Predicted Coffee Consumption and Risk of Alzheimer's Disease and Stroke. Journal of Alzheimer's Disease : Jad. PMID 34459406 DOI: 10.3233/JAD-210678   
2021 Jiang Z, Shi Y, Zhao W, Zhou L, Zhang B, Xie Y, Zhang Y, Tan G, Wang Z. Association between chronic periodontitis and the risk of Alzheimer's disease: combination of text mining and GEO dataset. Bmc Oral Health. 21: 466. PMID 34556089 DOI: 10.1186/s12903-021-01827-2   
2021 Paranjpe MD, Belonwu S, Wang JK, Oskotsky T, Gupta A, Taubes A, Zalocusky KA, Paranjpe I, Glicksberg BS, Huang Y, Sirota M. Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease. Frontiers in Aging Neuroscience. 13: 735611. PMID 34658838 DOI: 10.3389/fnagi.2021.735611