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Mitchell R O'Connell - Publications

Affiliations: 
Biochemistry and Biophysics University of Rochester Medical Center, Rochester, NY, United States 
Area:
Biochemical mechanisms of RNA-mediated gene regulation; RNA-targeting CRISPR tool development
Website:
https://www.urmc.rochester.edu/people/31029773-mitchell-r-o-connell
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Molina Vargas AM, Sinha S, Osborn R, Arantes PR, Patel A, Dewhurst S, Hardy DJ, Cameron A, Palermo G, O'Connell MR. New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity. Nucleic Acids Research. PMID 38033324 DOI: 10.1093/nar/gkad1132  0.528
2023 Sinha S, Molina Vargas AM, Arantes PR, Patel A, O'Connell MR, Palermo G. Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a. Nucleic Acids Research. PMID 38033317 DOI: 10.1093/nar/gkad1127  0.632
2023 Vargas AMM, Osborn R, Sinha S, Arantes PR, Patel A, Dewhurst S, Palermo G, O'Connell MR. New design strategies for ultra-specific CRISPR-Cas13a-based RNA-diagnostic tools with single-nucleotide mismatch sensitivity. Biorxiv : the Preprint Server For Biology. PMID 37547020 DOI: 10.1101/2023.07.26.550755  0.509
2023 Sinha S, Molina Vargas AM, Arantes PR, Patel A, O'Connell MR, Palermo G. RNA-mediated Allosteric Activation in CRISPR-Cas13a. Biorxiv : the Preprint Server For Biology. PMID 37546822 DOI: 10.1101/2023.07.27.550797  0.649
2023 Liu L, Xu Z, Molina Vargas AM, Dollery SJ, Schrlau MG, Cormier D, O'Connell MR, Tobin GJ, Du K. Aerosol Jet Printing-Enabled Dual-Function Electrochemical and Colorimetric Biosensor for SARS-CoV-2 Detection. Analytical Chemistry. PMID 37505456 DOI: 10.1021/acs.analchem.3c01724  0.421
2023 Liu L, Xu Z, Molina Vargas AM, Dollery SJ, Schrlau MG, Cormier D, O'Connell MR, Tobin GJ, Du K. Aerosol Jet Printing Enabled Dual-Function Electrochemical and Colorimetric Biosensor for SARS-CoV-2 Detection. Medrxiv : the Preprint Server For Health Sciences. PMID 37163082 DOI: 10.1101/2023.04.20.23288904  0.421
2023 VanderWal AR, Park JU, Polevoda B, Nicosia JK, Molina Vargas AM, Kellogg EH, O'Connell MR. Csx28 is a membrane pore that enhances CRISPR-Cas13b-dependent antiphage defense. Science (New York, N.Y.). 380: 410-415. PMID 37104586 DOI: 10.1126/science.abm1184  0.323
2023 Knott GJ, Lapinaite A, O'Connell MR. Methods special issue: RNA-targeting technologies. Methods (San Diego, Calif.). 212: 10-11. PMID 36792042 DOI: 10.1016/j.ymeth.2023.02.006  0.728
2022 Liu L, Xu Z, Awayda K, Dollery SJ, Bao M, Fan J, Cormier D, O'Connell M, Tobin GJ, Du K. Gold Nanoparticle-Labeled CRISPR-Cas13a Assay for the Sensitive Solid-State Nanopore Molecular Counting. Advanced Materials Technologies. 7. PMID 36338309 DOI: 10.1002/admt.202101550  0.437
2022 Burris BJD, Molina Vargas AM, Park BJ, O'Connell MR. Optimization of specific RNA knockdown in mammalian cells with CRISPR-Cas13. Methods (San Diego, Calif.). 206: 58-68. PMID 35987443 DOI: 10.1016/j.ymeth.2022.08.007  0.638
2020 Davis BJ, O'Connell MR. Put on Your Para-spectacles: The Development of Optimized CRISPR-Cas13-Based Approaches to Image RNA Dynamics in Real Time. Molecular Cell. 77: 207-209. PMID 31951545 DOI: 10.1016/j.molcel.2019.12.018  0.478
2018 De Franco S, O'Connell MR, Vandevenne M. Engineering RNA-Binding Proteins by Modular Assembly of RanBP2-Type Zinc Fingers. Methods in Molecular Biology (Clifton, N.J.). 1867: 57-74. PMID 30155815 DOI: 10.1007/978-1-4939-8799-3_5  0.675
2018 Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR. RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a. Cell Reports. 24: 1025-1036. PMID 30044970 DOI: 10.1016/J.Celrep.2018.06.105  0.787
2018 O'Connell MR. Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR-Cas Systems. Journal of Molecular Biology. PMID 29940185 DOI: 10.1016/J.Jmb.2018.06.029  0.669
2017 Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nature Structural & Molecular Biology. PMID 28892041 DOI: 10.1038/Nsmb.3466  0.78
2017 East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA. RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. Molecular Cell. 66: 373-383.e3. PMID 28475872 DOI: 10.1016/J.Molcel.2017.04.008  0.765
2016 East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. Nature. PMID 27669025 DOI: 10.1038/Nature19802  0.793
2016 Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW. Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell. 165: 488-96. PMID 26997482 DOI: 10.1016/J.Cell.2016.02.054  0.72
2015 Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes. Molecular Cell. 60: 398-407. PMID 26545076 DOI: 10.1016/J.Molcel.2015.10.030  0.623
2014 O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature. 516: 263-6. PMID 25274302 DOI: 10.1038/Nature13769  0.783
2014 Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP. The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins. Plos One. 9: e106011. PMID 25162672 DOI: 10.1371/Journal.Pone.0106011  0.486
2014 Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP. Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA. Angewandte Chemie (International Ed. in English). 53: 7848-52. PMID 25044781 DOI: 10.1002/Anie.201402980  0.758
2013 Gamsjaeger R, O'Connell MR, Cubeddu L, Shepherd NE, Lowry JA, Kwan AH, Vandevenne M, Swanton MK, Matthews JM, Mackay JP. A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers. The Journal of Biological Chemistry. 288: 35180-91. PMID 24097990 DOI: 10.1074/Jbc.M113.482075  0.578
2012 O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP. Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA. Angewandte Chemie (International Ed. in English). 51: 5371-5. PMID 22517726 DOI: 10.1002/Anie.201200866  0.712
2012 Bendak K, Loughlin FE, Cheung V, O'Connell MR, Crossley M, Mackay JP. A rapid method for assessing the RNA-binding potential of a protein. Nucleic Acids Research. 40: e105. PMID 22492509 DOI: 10.1093/Nar/Gks285  0.729
2012 Hsieh YS, Wilkinson BL, O'Connell MR, Mackay JP, Matthews JM, Payne RJ. Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Organic Letters. 14: 1910-3. PMID 22455748 DOI: 10.1021/Ol300557G  0.428
2012 Burdach J, O'Connell MR, Mackay JP, Crossley M. Two-timing zinc finger transcription factors liaising with RNA. Trends in Biochemical Sciences. 37: 199-205. PMID 22405571 DOI: 10.1016/J.Tibs.2012.02.001  0.667
2009 O'Connell MR, Gamsjaeger R, Mackay JP. The structural analysis of protein-protein interactions by NMR spectroscopy. Proteomics. 9: 5224-32. PMID 19834907 DOI: 10.1002/Pmic.200900303  0.504
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