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Toshiyuki Shimizu - Publications

Affiliations: 
Tokyo University, Minato-ku, Tōkyō-to, Japan 
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ishizaka ST, Hawkins L, Chen Q, Tago F, Yagi T, Sakaniwa K, Zhang Z, Shimizu T, Shirato M. A novel Toll-like receptor 7/8-specific antagonist E6742 Ameliorates clinically relevant disease parameters in murine models of lupus. European Journal of Pharmacology. 175962. PMID 37544422 DOI: 10.1016/j.ejphar.2023.175962  0.365
2023 Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, ... ... Shimizu T, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. The Journal of Experimental Medicine. 220. PMID 37462944 DOI: 10.1084/jem.20230054  0.33
2023 Sakaniwa K, Fujimura A, Shibata T, Shigematsu H, Ekimoto T, Yamamoto M, Ikeguchi M, Miyake K, Ohto U, Shimizu T. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nature Communications. 14: 164. PMID 36631495 DOI: 10.1038/s41467-023-35844-2  0.403
2021 Asami J, Shimizu T. Structural and functional understanding of the Toll-like receptors. Protein Science : a Publication of the Protein Society. PMID 33576548 DOI: 10.1002/pro.4043  0.437
2021 Ishida H, Asami J, Zhang Z, Nishizawa T, Shigematsu H, Ohto U, Shimizu T. Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nature Structural & Molecular Biology. PMID 33432245 DOI: 10.1038/s41594-020-00542-w  0.454
2020 Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, ... ... Shimizu T, et al. Structural analysis reveals TLR7 dynamics underlying antagonism. Nature Communications. 11: 5204. PMID 33060576 DOI: 10.1038/s41467-020-19025-z  0.465
2020 Sakaniwa K, Shimizu T. Targeting the innate immune receptor TLR8 using small-molecule agents. Corrigendum. Acta Crystallographica. Section D, Structural Biology. 76: 905-907. PMID 32876066 DOI: 10.1107/S2059798320010864  0.335
2020 Sakaniwa K, Shimizu T. Targeting the innate immune receptor TLR8 using small-molecule agents. Acta Crystallographica. Section D, Structural Biology. 76: 621-629. PMID 32627735 DOI: 10.1107/S2059798320006518  0.459
2020 Kanoh H, Nitta T, Go S, Inamori KI, Veillon L, Nihei W, Fujii M, Kabayama K, Shimoyama A, Fukase K, Ohto U, Shimizu T, Watanabe T, Shindo H, Aoki S, et al. Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity. The Embo Journal. e101732. PMID 32378734 DOI: 10.15252/Embj.2019101732  0.33
2020 Jiang S, Tanji H, Yin K, Zhang S, Sakaniwa K, Huang J, Yang Y, Li J, Ohto U, Shimizu T, Yin HH. Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface. Journal of Medicinal Chemistry. PMID 32233366 DOI: 10.1021/Acs.Jmedchem.9B02128  0.569
2019 Padilla-Salinas R, Anderson R, Sakaniwa K, Zhang S, Nordeen P, Lu C, Shimizu T, Yin HH. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-like Receptor 7 and 8. Journal of Medicinal Chemistry. PMID 31687820 DOI: 10.1021/Acs.Jmedchem.9B01201  0.542
2018 Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, Shukla NM, David SA, Isobe T, Miyake K, Shimizu T. Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Reports. 25: 3371-3381.e5. PMID 30566863 DOI: 10.1016/J.Celrep.2018.11.081  0.453
2018 Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H. Small-Molecule TLR8 Antagonists via Structure-Based Rational Design. Cell Chemical Biology. PMID 30100350 DOI: 10.1016/J.Chembiol.2018.07.004  0.572
2018 Ishida H, Ohto U, Shibata T, Miyake K, Shimizu T. Structural basis for species-specific activation of mouse Toll-like receptor 9. Febs Letters. PMID 29961984 DOI: 10.1002/1873-3468.13176  0.33
2018 Ohto U, Ishida H, Shibata T, Sato R, Miyake K, Shimizu T. Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation. Immunity. PMID 29625894 DOI: 10.1016/j.immuni.2018.03.013  0.315
2018 Miyake K, Shibata T, Ohto U, Shimizu T, Saitoh SI, Fukui R, Murakami Y. Mechanisms controlling nucleic-acid-sensing Toll-like receptors. International Immunology. PMID 29452403 DOI: 10.1093/intimm/dxy016  0.403
2017 Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U, Shimizu T, Yin H. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nature Chemical Biology. PMID 29155428 DOI: 10.1038/Nchembio.2518  0.583
2017 Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, et al. Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex. The Journal of Biological Chemistry. PMID 28754693 DOI: 10.1074/jbc.M117.791780  0.394
2017 Zhang Z, Ohto U, Shimizu T. Towards a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system. Febs Letters. PMID 28686285 DOI: 10.1002/1873-3468.12749  0.36
2017 Shimizu T. Structural insights into ligand recognition and regulation of nucleic acid-sensing Toll-like receptors. Current Opinion in Structural Biology. 47: 52-59. PMID 28600980 DOI: 10.1016/j.sbi.2017.05.010  0.337
2016 Ohto U, Shimizu T. Structural aspects of nucleic acid-sensing Toll-like receptors. Biophysical Reviews. 8: 33-43. PMID 28510149 DOI: 10.1007/s12551-015-0187-1  0.395
2016 Zhang Z, Ohto U, Shibata T, Krayukhina E, Taoka M, Yamauchi Y, Tanji H, Isobe T, Uchiyama S, Miyake K, Shimizu T. Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA. Immunity. PMID 27742543 DOI: 10.1016/j.immuni.2016.09.011  0.419
2016 Beesu M, Caruso G, Salyer AC, Shukla NM, Khetani KK, Smith LJ, Fox LM, Tanji H, Ohto U, Shimizu T, David SA. Identification of a Human Toll-like Receptor (TLR) 8-specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles. Journal of Medicinal Chemistry. PMID 26966993 DOI: 10.1021/Acs.Jmedchem.6B00023  0.456
2016 Tanji H, Ohto U, Motoi Y, Shibata T, Miyake K, Shimizu T. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8. Proceedings of the National Academy of Sciences of the United States of America. 113: 3012-7. PMID 26929371 DOI: 10.1073/pnas.1516000113  0.378
2016 Shimizu T. [Structural Analyses of Toll-like Receptor Sensing Single-stranded Nucleic Acids and Its Application]. Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan. 136: 173-8. PMID 26831789 DOI: 10.1248/yakushi.15-00229-1  0.466
2016 Tanji H, Ohto U, Motoi Y, Shibata T, Miyake K, Shimizu T. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8 Proceedings of the National Academy of Sciences of the United States of America. 113: 3012-3017. DOI: 10.1073/pnas.1516000113  0.378
2016 Ohto U, Shimizu T. Structural aspects of nucleic acid-sensing Toll-like receptors Biophysical Reviews. 8: 33-43. DOI: 10.1007/s12551-015-0187-1  0.396
2015 Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K. Guanosine and its modified derivatives are endogenous ligands for TLR7. International Immunology. PMID 26489884 DOI: 10.1093/intimm/dxv062  0.414
2015 Beesu M, Caruso G, Salyer AC, Khetani KK, Sil D, Weerasinghe M, Tanji H, Ohto U, Shimizu T, David SA. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. Journal of Medicinal Chemistry. 58: 7833-49. PMID 26351878 DOI: 10.1021/Acs.Jmedchem.5B01087  0.447
2015 Ohto U, Shibata T, Tanji H, Ishida H, Krayukhina E, Uchiyama S, Miyake K, Shimizu T. Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature. 520: 702-5. PMID 25686612 DOI: 10.1038/nature14138  0.357
2015 Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, et al. Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases. Nature Communications. 6: 6119. PMID 25648980 DOI: 10.1038/ncomms7119  0.371
2015 Tanji H, Ohto U, Shibata T, Taoka M, Yamauchi Y, Isobe T, Miyake K, Shimizu T. Toll-like receptor 8 senses degradation products of single-stranded RNA. Nature Structural & Molecular Biology. 22: 109-15. PMID 25599397 DOI: 10.1038/nsmb.2943  0.4
2014 Yoo E, Salunke DB, Sil D, Guo X, Salyer AC, Hermanson AR, Kumar M, Malladi SS, Balakrishna R, Thompson WH, Tanji H, Ohto U, Shimizu T, David SA. Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds. Journal of Medicinal Chemistry. 57: 7955-70. PMID 25192394 DOI: 10.1021/Jm500744F  0.423
2014 Ohto U, Tanji H, Shimizu T. Structure and function of toll-like receptor 8. Microbes and Infection / Institut Pasteur. 16: 273-82. PMID 24513445 DOI: 10.1016/j.micinf.2014.01.007  0.422
2014 Ohto U, Tanji H, Shibata T, Krayukhina E, Uchiyama S, Miyake K, Shimizu T. Structural studies of nucleic acid sensing Toll-like receptor Acta Crystallographica Section a Foundations and Advances. 70: C252-C252. DOI: 10.1107/S2053273314097472  0.462
2013 Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. Science (New York, N.Y.). 339: 1426-9. PMID 23520111 DOI: 10.1126/science.1229159  0.435
2013 Yamakawa N, Ohto U, Akashi-Takamura S, Takahashi K, Saitoh S, Tanimura N, Suganami T, Ogawa Y, Shibata T, Shimizu T, Miyake K. Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A. International Immunology. 25: 45-52. PMID 22962435 DOI: 10.1093/intimm/dxs084  0.392
2013 TANJI H, OHTO U, SHIMIZU T. Crystal Structures of Innate Immune RNA Receptor TLR8 Nihon Kessho Gakkaishi. 55: 285-289. DOI: 10.5940/JCRSJ.55.285  0.345
2012 Ohto U, Fukase K, Miyake K, Shimizu T. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proceedings of the National Academy of Sciences of the United States of America. 109: 7421-6. PMID 22532668 DOI: 10.1073/pnas.1201193109  0.392
2011 Ohto U, Miyake K, Shimizu T. Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. Journal of Molecular Biology. 413: 815-25. PMID 21959264 DOI: 10.1016/j.jmb.2011.09.020  0.438
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