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Kui Cheng - Publications

Affiliations: 
2009-2014 Southern Medical University, Guangzhou Shi, Guangdong Sheng, China 
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ou J, Zheng L, Chen Y, Fu Q, Tan L, Liang E, Huang L, Pan Y, Ke J, Chen Z, Cheng K. Heterocyclic-Modified Imidazoquinoline Derivatives: Selective TLR7 Agonist Regulates Tumor Microenvironment against Melanoma. Journal of Medicinal Chemistry. PMID 38363069 DOI: 10.1021/acs.jmedchem.3c01504  0.336
2023 Yang J, Pan Y, Zeng X, Liu S, Chen Z, Cheng K. Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation. Acta Pharmaceutica Sinica. B. 13: 3782-3801. PMID 37719381 DOI: 10.1016/j.apsb.2023.05.034  0.395
2022 Cen X, Wang B, Liang Y, Chen Y, Xiao Y, Du S, Nandakumar KS, Yin H, Liu S, Cheng K. Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy. Acta Pharmaceutica Sinica. B. 12: 3667-3681. PMID 36176917 DOI: 10.1016/j.apsb.2022.06.001  0.372
2021 Chen Z, Zhang L, Yang J, Zheng L, Hu F, Duan S, Nandakumar KS, Liu S, Yin H, Cheng K. Design, Synthesis, and Structure-Activity Relationship of -Aryl-'-(thiophen-2-yl)thiourea Derivatives as Novel and Specific Human TLR1/2 Agonists for Potential Cancer Immunotherapy. Journal of Medicinal Chemistry. PMID 34029463 DOI: 10.1021/acs.jmedchem.0c02266  0.345
2019 Bi J, Wang W, Du J, Chen K, Cheng K. Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents. European Journal of Medicinal Chemistry. 179: 233-245. PMID 31255924 DOI: 10.1016/j.ejmech.2019.06.059  0.323
2019 Cen X, Zhu G, Yang J, Yang J, Guo J, Jin J, Nandakumar KS, Yang W, Yin H, Liu S, Cheng K. TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 6: 1802042. PMID 31131189 DOI: 10.1002/advs.201802042  0.34
2019 Chen Z, Cen X, Yang J, Lin Z, Liu M, Cheng K. Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors. European Journal of Medicinal Chemistry. 169: 42-52. PMID 30852386 DOI: 10.1016/j.ejmech.2019.02.067  0.374
2018 Chen Z, Cen X, Yang J, Tang X, Cui K, Cheng K. Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library database. Chemical Communications (Cambridge, England). PMID 30246199 DOI: 10.1039/c8cc06618c  0.305
2018 Cen X, Liu S, Cheng K. The Role of Toll-Like Receptor in Inflammation and Tumor Immunity. Frontiers in Pharmacology. 9: 878. PMID 30127747 DOI: 10.3389/fphar.2018.00878  0.31
2018 Bhattacharyya S, Wang W, Qin W, Cheng K, Coulup S, Chavez S, Jiang S, Raparia K, De Almeida LMV, Stehlik C, Tamaki Z, Yin H, Varga J. TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung. Jci Insight. 3. PMID 29997297 DOI: 10.1172/Jci.Insight.98850  0.612
2018 Xu Y, Chen S, Cao Y, Zhou P, Chen Z, Cheng K. Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents. European Journal of Medicinal Chemistry. 154: 253-266. PMID 29807331 DOI: 10.1016/j.ejmech.2018.05.033  0.335
2018 Cai S, Zhu G, Cen X, Bi J, Zhang J, Tang X, Chen K, Cheng K. Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors. Bioorganic & Medicinal Chemistry. PMID 29534935 DOI: 10.1016/j.bmc.2018.03.001  0.409
2017 Zhu G, Xu Y, Cen X, Nandakumar KS, Liu S, Cheng K. Targeting pattern-recognition receptors to discover new small molecule immune modulators. European Journal of Medicinal Chemistry. 144: 82-92. PMID 29268133 DOI: 10.1016/j.ejmech.2017.12.026  0.343
2016 Xu Q, Zhu G, Li J, Cheng K. Development of antibacterial drugs by targeting toll-like receptors. Current Topics in Medicinal Chemistry. PMID 27572080  0.34
2016 Yan L, Liang J, Yao C, Wu P, Zeng X, Cheng K, Yin H. Cover Picture: Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors (ChemMedChem 8/2016) Chemmedchem. 11: 730-730. DOI: 10.1002/Cmdc.201600184  0.629
2015 Yan L, Liang J, Yao C, Wu P, Zeng X, Cheng K, Yin H. Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors. Chemmedchem. PMID 26634412 DOI: 10.1002/Cmdc.201500471  0.663
2015 Cheng K, Gao M, Godfroy JI, Brown PN, Kastelowitz N, Yin H. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Science Advances. 1. PMID 26101787 DOI: 10.1126/Sciadv.1400139  0.62
2015 Daniele SG, Béraud D, Davenport C, Cheng K, Yin H, Maguire-Zeiss KA. Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders. Science Signaling. 8: ra45. PMID 25969543 DOI: 10.1126/Scisignal.2005965  0.578
2015 Yan L, de Jesus AJ, Tamura R, Li V, Cheng K, Yin H. Curvature sensing MARCKS-ED peptides bind to membranes in a stereo-independent manner. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 577-85. PMID 25851418 DOI: 10.1002/Psc.2772  0.677
2015 Gao M, Cheng K, Yin H. Targeting protein-protein interfaces using macrocyclic peptides. Biopolymers. PMID 25664609 DOI: 10.1002/Bip.22625  0.54
2015 D'Atri LP, Etulain J, Rivadeneyra L, Lapponi MJ, Centurion M, Cheng K, Yin H, Schattner M. Expression and functionality of Toll-like receptor 3 in the megakaryocytic lineage. Journal of Thrombosis and Haemostasis : Jth. 13: 839-50. PMID 25594115 DOI: 10.1111/Jth.12842  0.617
2014 Gao M, London N, Cheng K, Tamura R, Jin J, Schueler-Furman O, Yin H. Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response. Tetrahedron. 70: 7664-7668. PMID 25400297 DOI: 10.1016/J.Tet.2014.07.026  0.627
2013 Cheng K, Xue JY, Zhu HL. Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 4235-8. PMID 23731945 DOI: 10.1016/J.Bmcl.2013.05.006  0.321
2013 Wang X, Grace PM, Pham MN, Cheng K, Strand KA, Smith C, Li J, Watkins LR, Yin H. Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2713-22. PMID 23568774 DOI: 10.1096/Fj.12-222992  0.654
2012 Zhang S, Cheng K, Wang X, Yin H. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorganic & Medicinal Chemistry. 20: 6073-9. PMID 22985959 DOI: 10.1016/J.Bmc.2012.08.022  0.71
2012 Cheng K, Wang X, Zhang S, Yin H. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angewandte Chemie (International Ed. in English). 51: 12246-9. PMID 22969053 DOI: 10.1002/Anie.201204910  0.732
2012 Miyauchi K, Urano E, Takeda S, Murakami T, Okada Y, Cheng K, Yin H, Kubo M, Komano J. Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells. Biochemical and Biophysical Research Communications. 424: 519-23. PMID 22771581 DOI: 10.1016/J.Bbrc.2012.06.148  0.612
2012 Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas J, Cheng K, Reddy A, Somogyi AA, Hutchinson MR, Watkins LR, Yin H. Morphine activates neuroinflammation in a manner parallel to endotoxin. Proceedings of the National Academy of Sciences of the United States of America. 109: 6325-30. PMID 22474354 DOI: 10.1073/Pnas.1200130109  0.694
2012 Cheng K, Wang X, Zhang S, Yin H. Inside Back Cover: Discovery of Small‐Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. Int. Ed. 49/2012) Angewandte Chemie. 51: 12375-12375. DOI: 10.1002/Anie.201208674  0.713
2012 Cheng K, Wang X, Zhang S, Yin H. Innenrücktitelbild: Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex (Angew. Chem. 49/2012) Angewandte Chemie. 124: 12543-12543. DOI: 10.1002/Ange.201208674  0.71
2011 Chavez SA, Martinko AJ, Lau C, Pham MN, Cheng K, Bevan DE, Mollnes TE, Yin H. Development of β-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics. Journal of Medicinal Chemistry. 54: 4659-69. PMID 21591694 DOI: 10.1021/Jm2003365  0.615
2011 Cheng K, Wang X, Yin H. Small-molecule inhibitors of the TLR3/dsRNA complex. Journal of the American Chemical Society. 133: 3764-7. PMID 21355588 DOI: 10.1021/Ja111312H  0.677
2010 Qian Y, Ma GY, Yang Y, Cheng K, Zheng QZ, Mao WJ, Shi L, Zhao J, Zhu HL. Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents. Bioorganic & Medicinal Chemistry. 18: 4310-6. PMID 20493717 DOI: 10.1016/J.Bmc.2010.04.091  0.304
2010 Cheng K, Zheng QZ, Hou J, Zhou Y, Liu CH, Zhao J, Zhu HL. Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. Bioorganic & Medicinal Chemistry. 18: 2447-55. PMID 20304657 DOI: 10.1016/J.Bmc.2010.02.052  0.319
2009 Cheng K, Zheng QZ, Qian Y, Shi L, Zhao J, Zhu HL. Synthesis, antibacterial activities and molecular docking studies of peptide and Schiff bases as targeted antibiotics. Bioorganic & Medicinal Chemistry. 17: 7861-71. PMID 19884012 DOI: 10.1016/J.Bmc.2009.10.037  0.326
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