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Christie Brouillette - Publications

Affiliations: 
Chemistry University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Protein Structural Cooperativity and Energetics, Biophysics, Antibacterial Drug Discovery
Website:
https://www.uab.edu/csb/faculty/christie-brouillette
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2009 Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ. SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. Journal of Combinatorial Chemistry. 11: 617-25. PMID 19408950 DOI: 10.1021/Cc9000357  0.381
2009 Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & Medicinal Chemistry Letters. 19: 2001-5. PMID 19249205 DOI: 10.1016/J.Bmcl.2009.02.034  0.304
2007 McDonald HM, Pruett PS, Deivanayagam C, Protasevich II, Carson WM, DeLucas LJ, Brouillette WJ, Brouillette CG. Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis. Acta Crystallographica. Section D, Biological Crystallography. 63: 891-905. PMID 17642516 DOI: 10.1107/S0907444907029769  0.348
2007 Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21. PMID 17489580 DOI: 10.1021/Jm061349L  0.367
2005 Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ. Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904. PMID 16283799 DOI: 10.1021/Cc050063J  0.344
2004 Protasevich II, Brouillette CG, Snow ME, Dunham S, Rubin JR, Gogliotti R, Siegel K. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance. Biochemistry. 43: 13380-9. PMID 15491144 DOI: 10.1021/bi0492509  0.402
2004 Yang ZW, Tendian SW, Carson WM, Brouillette WJ, Delucas LJ, Brouillette CG. Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase. Protein Science : a Publication of the Protein Society. 13: 830-41. PMID 14978314 DOI: 10.1110/Ps.03330104  0.302
2003 Chesnokova LS, Slepenkov SV, Protasevich II, Sehorn MG, Brouillette CG, Witt SN. Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis. Biochemistry. 42: 9028-40. PMID 12885236 DOI: 10.1021/Bi0346493  0.303
2003 Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ. Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81. PMID 12852767 DOI: 10.1021/Jm030003X  0.34
2001 Devedjiev Y, Symersky J, Singh R, Jedrzejas M, Brouillette C, Brouillette W, Muccio D, Chattopadhyay D, DeLucas L. Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis. Acta Crystallographica. Section D, Biological Crystallography. 57: 806-12. PMID 11375500 DOI: 10.1107/S0907444901003523  0.365
1999 Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry. Biochemistry. 38: 13592-601. PMID 10521266 DOI: 10.1021/BI991222G  0.342
1992 Lim WK, Brouillette C, Hardman JK. Thermal stabilities of mutant Escherichia coli tryptophan synthase alpha subunits. Archives of Biochemistry and Biophysics. 292: 34-41. PMID 1727648 DOI: 10.1016/0003-9861(92)90047-Z  0.327
1979 Brouillette CB, Chang CT, Mertes MP. 5-(alpha-Bromoacetyl)-2'-deoxyuridine 5'-phosphate: an affinity label for thymidylate synthetase. Journal of Medicinal Chemistry. 22: 1541-4. PMID 119854 DOI: 10.1021/Jm00198A022  0.472
1979 Brouillette CB, Chang CT, Mertes MP. 5 (alpha-bromoacetyl)-2'=deoxyuridine 5'-phosphate: a mechanism based affinity label for thymidylate synthetase. Biochemical and Biophysical Research Communications. 87: 613-8. PMID 109088 DOI: 10.1016/0006-291X(79)91838-2  0.472
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