Shuyi Si - Publications

Affiliations: 
microbiology and biochemical pharmacy Peking Union Medical College 

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu D, Qiao X, Ge Z, Shang Y, Li Y, Wang W, Chen M, Si S, Chen SZ. IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway. Skeletal Muscle. 9: 8. PMID 30922397 DOI: 10.1186/s13395-019-0193-2  0.56
2019 Han X, Gong S, Li N, Wang X, Liu P, Xu Y, He X, Jiang W, Si S. A Novel Small Molecule Which Increases Osteoprotegerin Expression and Protects Against Ovariectomy-Related Bone Loss in Rats. Frontiers in Pharmacology. 10: 103. PMID 30914947 DOI: 10.3389/fphar.2019.00103  0.56
2019 Chen M, Wang R, Zhao W, Yu L, Zhang C, Chang S, Li Y, Zhang T, Xing J, Gan M, Feng F, Si S. Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp. Organic Letters. PMID 30785290 DOI: 10.1021/acs.orglett.9b00385  0.72
2018 Zhu N, Wang X, Li D, Lin Y, You X, Jiang J, Xu Y, Jiang W, Si S. IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis. Scientific Reports. 8: 17439. PMID 30487577 DOI: 10.1038/s41598-018-35701-z  0.68
2018 Zhang X, Li Y, Wang W, Zhang J, Lin Y, Hong B, You X, Song D, Wang Y, Jiang J, Si S. Identification of an anti-Gram-negative bacteria agent disrupting the interaction between LPS transporters LptA and LptC. International Journal of Antimicrobial Agents. PMID 30476569 DOI: 10.1016/j.ijantimicag.2018.11.016  0.68
2018 Wang W, Liu C, Zhu N, Lin Y, Jiang J, Wang Y, Li Y, Si S. Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10. Acta Pharmaceutica Sinica. B. 8: 772-783. PMID 30245964 DOI: 10.1016/j.apsb.2018.07.006  0.68
2018 Wang X, Luo J, Li N, Liu L, Han X, Liu C, Zuo X, Jiang X, Li Y, Xu Y, Si S. E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression. Biochemical and Biophysical Research Communications. PMID 30173890 DOI: 10.1016/j.bbrc.2018.08.125  0.56
2018 Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG. Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics. 8: 3007-3021. PMID 29896299 DOI: 10.7150/thno.21966  0.56
2018 Feng T, Liu P, Wang X, Luo J, Zuo X, Jiang X, Liu C, Li Y, Li N, Chen M, Zhu N, Han X, Liu C, Xu Y, Si S. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Atherosclerosis. 274: 172-181. PMID 29787963 DOI: 10.1016/j.atherosclerosis.2018.04.039  0.56
2018 Lin Y, Zhang H, Zhu N, Wang X, Han Y, Chen M, Jiang J, Si S. Identification of TB-E12 as a novel FtsZ inhibitor with anti-tuberculosis activity. Tuberculosis (Edinburgh, Scotland). 110: 79-85. PMID 29779778 DOI: 10.1016/j.tube.2018.04.002  0.68
2018 Liu P, Feng T, Zuo X, Wang X, Luo J, Li N, Han X, Zhu N, Xu S, Xu Y, Jin ZG, Si S. A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKAmice. Biochemical and Biophysical Research Communications. PMID 29524414 DOI: 10.1016/j.bbrc.2018.03.034  0.56
2018 Xing Y, Zhao S, Wei Q, Gong S, Zhao X, Zhou F, Ai-Lamki R, Ortmann D, Du M, Pedersen R, Shang G, Si S, Morrell NW, Yang J. A novel piperidine identified by stem cell based screening attenuates pulmonary arterial hypertensionregulating BMP2 and PTGS2 levels. The European Respiratory Journal. PMID 29449428 DOI: 10.1183/13993003.02229-2017  0.52
2018 Gong J, Zheng Y, Wang Y, Sheng W, Li Y, Liu X, Si S, Shao R, Zhen Y. A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway. Plos One. 13: e0191984. PMID 29394294 DOI: 10.1371/journal.pone.0191984  0.56
2017 Xu Y, Xu S, Liu P, Koroleva M, Zhang S, Si S, Jin ZG. Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis. Journal of the American Heart Association. 6. PMID 29191808 DOI: 10.1161/JAHA.117.007134  0.56
2017 Xu Y, Liu P, Xu S, Koroleva M, Zhang S, Si S, Jin ZG. Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells. Scientific Reports. 7: 6686. PMID 28751752 DOI: 10.1038/s41598-017-06803-x  0.56
2017 Li N, Wang X, Xu Y, Lin Y, Zhu N, Liu P, Lu D, Si S. Identification of a novel liver X receptor agonist that regulates the expression of key cholesterol homeostasis genes with distinct pharmacological characteristics. Molecular Pharmacology. PMID 28087808 DOI: 10.1124/mol.116.105213  0.68
2016 Chen Y, Zhang J, Li D, Jiang J, Wang Y, Si S. Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain. Oncotarget. PMID 27902479 DOI: 10.18632/oncotarget.13603  0.56
2016 Jiang Z, Lei X, Chen M, Jiang B, Wu L, Zhang X, Zheng Z, Hu X, You X, Si S, Wang L, Hong B. Three structurally-related impurities in norvancomycin drug substance. The Journal of Antibiotics. PMID 27703158 DOI: 10.1038/ja.2016.115  0.56
2016 Gong S, Han X, Li X, Yang J, He X, Si S. Development of a High-Throughput Screening Strategy for Upregulators of the OPG/RANKL Ratio with the Potential for Antiosteoporosis Effects. Journal of Biomolecular Screening. PMID 27301430 DOI: 10.1177/1087057116654657  0.56
2016 Li N, Wang X, Liu P, Lu D, Jiang W, Xu Y, Si S. E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro. Acta Pharmaceutica Sinica. B. 6: 198-204. PMID 27175330 DOI: 10.1016/j.apsb.2016.03.005  0.56
2016 Shi Y, Jiang Z, Lei X, Zhang N, Cai Q, Li Q, Wang L, Si S, Xie Y, Hong B. Improving the N-terminal diversity of sansanmycin through mutasynthesis. Microbial Cell Factories. 15: 77. PMID 27154005 DOI: 10.1186/s12934-016-0471-1  0.56
2015 Jiang H, Zhang J, Du Y, Jia X, Yang F, Si S, Wang L, Hong B. microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator. Atherosclerosis. 243: 523-532. PMID 26523989 DOI: 10.1016/j.atherosclerosis.2015.10.026  0.56
2015 Li D, Gao N, Zhu N, Lin Y, Li Y, Chen M, You X, Lu Y, Wan K, Jiang JD, Jiang W, Si S. Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB. Bioorganic & Medicinal Chemistry Letters. PMID 26459210 DOI: 10.1016/j.bmcl.2015.09.072  0.56
2015 Liu C, Feng T, Zhu N, Liu P, Han X, Chen M, Wang X, Li N, Li Y, Xu Y, Si S. Corrigendum: Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis. Scientific Reports. 5: 12185. PMID 26244753 DOI: 10.1038/srep12185  0.56
2015 Zhu N, Lin Y, Li D, Gao N, Liu C, You X, Jiang J, Jiang W, Si S. Identification of an anti-TB compound targeting the tyrosyl-tRNA synthetase. The Journal of Antimicrobial Chemotherapy. 70: 2287-94. PMID 25957580 DOI: 10.1093/jac/dkv110  0.68
2015 Niu Y, Si Y, Li Y, Chi X, Li X, Liu X, Li D, Cheng M, Fan J, Si S, Yang W. A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3. The Journal of Antimicrobial Chemotherapy. 70: 2013-23. PMID 25858355 DOI: 10.1093/jac/dkv077  0.56
2015 Liu C, Feng T, Zhu N, Liu P, Han X, Chen M, Wang X, Li N, Li Y, Xu Y, Si S. Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis. Scientific Reports. 5: 9530. PMID 25827822 DOI: 10.1038/srep09530  0.56
2015 Du Y, Wang L, Si S, Yang Y, Hong B. A novel compound 4010B-30 upregulates apolipoprotein A-I gene expression through activation of PPARγ in HepG2 cells. Atherosclerosis. 239: 589-98. PMID 25734982 DOI: 10.1016/j.atherosclerosis.2015.02.030  0.4
2015 Chen M, Wu Y, He Y, Xu Y, Li Y, Li D, Feng T, Yu L, Hong B, Jiang W, Si S. Identification of trichostatin derivatives from Streptomyces sp. CPCC 203909. Bioorganic & Medicinal Chemistry Letters. 25: 562-5. PMID 25556102 DOI: 10.1016/j.bmcl.2014.12.030  0.72
2014 Li N, Wang X, Zhang J, Liu C, Li Y, Feng T, Xu Y, Si S. Identification of a novel partial agonist of liver X receptor α (LXRα) via screening. Biochemical Pharmacology. 92: 438-47. PMID 25450668 DOI: 10.1016/j.bcp.2014.09.017  0.56
2014 Li Y, Feng T, Liu P, Liu C, Wang X, Li D, Li N, Chen M, Xu Y, Si S. Optimization of Rutaecarpine as ABCA1 Up-Regulator for Treating Atherosclerosis. Acs Medicinal Chemistry Letters. 5: 884-8. PMID 25147608 DOI: 10.1021/ml500131a  0.56
2014 Lin Y, Zhu N, Han Y, Jiang J, Si S. Identification of anti-tuberculosis agents that target the cell-division protein FtsZ. The Journal of Antibiotics. 67: 671-6. PMID 24984796 DOI: 10.1038/ja.2014.89  0.68
2014 Xu Y, Liu Q, Xu Y, Liu C, Wang X, He X, Zhu N, Liu J, Wu Y, Li Y, Li N, Feng T, Lai F, Zhang M, Hong B, ... ... Si S, et al. Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT. Journal of Lipid Research. 55: 1634-1647. PMID 24908654 DOI: 10.1194/jlr.M044198  0.56
2014 Lin Y, Li Y, Zhu N, Han Y, Jiang W, Wang Y, Si S, Jiang J. The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10. Antimicrobial Agents and Chemotherapy. 58: 2038-44. PMID 24449778 DOI: 10.1128/AAC.02394-13  0.68
2014 Li Y, Zhang X, Zhang J, Li Y, Liu W, Wang Z, Wang Y, Si S. A small molecule, MTBT, prevents cancer cell growth by activating p38 MAPK. Anti-Cancer Drugs. 25: 423-32. PMID 24441745 DOI: 10.1097/CAD.0000000000000074  0.56
2014 Li N, Xu Y, Feng T, Liu C, Li Y, Wang X, Si S. Identification of a selective agonist for liver X receptor α (LXRα) via screening of a synthetic compound library. Journal of Biomolecular Screening. 19: 566-74. PMID 24334278 DOI: 10.1177/1087057113516004  0.56
2013 Li S, Ni S, Wu L, Li L, Jiang B, Wang H, Sun G, Gan M, Li J, He W, Lin L, Wang Y, Bai S, Si S. 19-[(1'S,4'R)-4'-Hydroxy-1'-methoxy-2'-oxopentyl]geldanamycin, a natural geldanamycin analogue from Streptomyces hygroscopicus 17997. Journal of Natural Products. 76: 969-73. PMID 23656556 DOI: 10.1021/np4000679  0.72
2013 Lai F, Madan N, Ye Q, Duan Q, Li Z, Wang S, Si S, Xie Z. Identification of a mutant α1 Na/K-ATPase that pumps but is defective in signal transduction. The Journal of Biological Chemistry. 288: 13295-304. PMID 23532853 DOI: 10.1074/jbc.M113.467381  0.56
2013 Kobayashi K, Ohshiro T, Matsuda D, Jiang W, Hong B, Si S, Tomoda H. The mechanism of action of bufalin in inhibition of lipid droplet accumulation in mouse macrophages. Biological & Pharmaceutical Bulletin. 36: 364-9. PMID 23449325 DOI: DN/JST.JSTAGE/bpb/b12-00722  0.56
2013 Ye Q, Lai F, Banerjee M, Duan Q, Li Z, Si S, Xie Z. Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction. The Journal of Biological Chemistry. 288: 5803-14. PMID 23288841 DOI: 10.1074/jbc.M112.442608  0.4
2013 Gao N, Jiang W, Gao H, Cheng Z, Qian H, Si S, Xie Y. Structural basis of human transcription factor Sry-related box 17 binding to DNA. Protein and Peptide Letters. 20: 481-8. PMID 23061670  0.68
2012 Liu X, Gan M, Dong B, Zhang T, Li Y, Zhang Y, Fan X, Wu Y, Bai S, Chen M, Yu L, Tao P, Jiang W, Si S. 4862F, a new inhibitor of HIV-1 protease, from the culture of Streptomyces I03A-04862. Molecules (Basel, Switzerland). 18: 236-43. PMID 23271463 DOI: 10.3390/molecules18010236  0.72
2012 Han X, Zhang J, Guo L, Cao R, Li Y, Li N, Ma Q, Wu J, Wang Y, Si S. A series of beta-carboline derivatives inhibit the kinase activity of PLKs. Plos One. 7: e46546. PMID 23056340 DOI: 10.1371/journal.pone.0046546  0.56
2012 Lin Y, Li Y, Zhu Y, Zhang J, Li Y, Liu X, Jiang W, Yu S, You XF, Xiao C, Hong B, Wang Y, Jiang JD, Si S. Identification of antituberculosis agents that target ribosomal protein interactions using a yeast two-hybrid system. Proceedings of the National Academy of Sciences of the United States of America. 109: 17412-7. PMID 23045703 DOI: 10.1073/pnas.1110271109  0.56
2012 Bao Y, Wang L, Xu Y, Yang Y, Wang L, Si S, Cho S, Hong B. Salvianolic acid B inhibits macrophage uptake of modified low density lipoprotein (mLDL) in a scavenger receptor CD36-dependent manner. Atherosclerosis. 223: 152-9. PMID 22658257 DOI: 10.1016/j.atherosclerosis.2012.05.006  0.56
2012 Liu J, Zhang Z, Xu Y, Feng T, Jiang W, Li Z, Hong B, Xie Z, Si S. IMB2026791, a xanthone, stimulates cholesterol efflux by increasing the binding of apolipoprotein A-I to ATP-binding cassette transporter A1. Molecules (Basel, Switzerland). 17: 2833-54. PMID 22399138 DOI: 10.3390/molecules17032833  0.56
2011 Wang X, Akasaka R, Takemoto C, Morita S, Yamaguchi M, Terada T, Shirozu M, Yokoyama S, Chen S, Si S, Xie Y. Overexpression, purification, crystallization and preliminary crystallographic studies of a hyperthermophilic adenylosuccinate synthetase from Pyrococcus horikoshii OT3. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1551-5. PMID 22139164 DOI: 10.1107/S174430911104108X  0.68
2011 Xu Y, Lai F, Xu Y, Wu Y, Liu Q, Li N, Wei Y, Feng T, Zheng Z, Jiang W, Yu L, Hong B, Si S. Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPARγ-LXRα-ABCA1 pathway. Biochemical and Biophysical Research Communications. 414: 779-82. PMID 22005457 DOI: 10.1016/j.bbrc.2011.10.002  0.72
2011 Zheng Z, Yang Y, Shao H, Liu Z, Lu X, Xu Y, He X, Jiang W, Jiang Q, Zhao B, Zhang H, Li Z, Si S. Two thiophenes compounds are partial peroxisome proliferator-activated receptor α/γ dual agonists. Biological & Pharmaceutical Bulletin. 34: 1631-4. PMID 21963508 DOI: JST.JSTAGE/bpb/34.1631  0.56
2011 Xu Y, Xu Y, Bao Y, Hong B, Si S. Identification of dehydroxytrichostatin A as a novel up-regulator of the ATP-binding cassette transporter A1 (ABCA1). Molecules (Basel, Switzerland). 16: 7183-98. PMID 21869747 DOI: 10.3390/molecules16097183  0.56
2011 Lin Y, Chen S, Si S, Xie Y. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the hyperthermophilic nucleotidyltransferase TTHA1015 from Thermus thermophilus HB8. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 782-4. PMID 21795793 DOI: 10.1107/S1744309111017490  0.68
2011 Gan M, Zheng X, Gan L, Guan Y, Hao X, Liu Y, Si S, Zhang Y, Yu L, Xiao C. Streptothricin derivatives from Streptomyces sp. I08A 1776. Journal of Natural Products. 74: 1142-7. PMID 21510638 DOI: 10.1021/np2000733  0.72
2010 Yang Y, Wang L, Si S, Hong B. How can high-throughput screening deliver drugs to treat atherosclerosis? Expert Opinion On Drug Discovery. 5: 1175-88. PMID 22822720 DOI: 10.1517/17460441.2010.529896  0.4
2010 Zhang Z, Li Z, Tian J, Jiang W, Wang Y, Zhang X, Li Z, You Q, Shapiro JI, Si S, Xie Z. Identification of hydroxyxanthones as Na/K-ATPase ligands. Molecular Pharmacology. 77: 961-7. PMID 20335388 DOI: 10.1124/mol.110.063974  0.56
2010 Xu Y, Wang J, Bao Y, Jiang W, Zuo L, Song D, Hong B, Si S. Identification of two antagonists of the scavenger receptor CD36 using a high-throughput screening model. Analytical Biochemistry. 400: 207-12. PMID 20152792 DOI: 10.1016/j.ab.2010.02.003  0.56
2010 Wang L, Bao Y, Yang Y, Wu Y, Chen X, Si S, Hong B. Discovery of antagonists for human scavenger receptor CD36 via an ELISA-like high-throughput screening assay. Journal of Biomolecular Screening. 15: 239-50. PMID 20150587 DOI: 10.1177/1087057109359686  0.44
2009 Zhang J, Li Y, Guo L, Cao R, Zhao P, Jiang W, Ma Q, Yi H, Li Z, Jiang J, Wu J, Wang Y, Si S. DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer Biology & Therapy. 8: 2374-83. PMID 19855194  0.56
2009 Li X, Yang J, He X, Yang Z, Ding Y, Zhao P, Liu Z, Shao H, Li Z, Zhang Y, Si S. Identification of upregulators of BMP2 expression via high-throughput screening of a synthetic and natural compound library. Journal of Biomolecular Screening. 14: 1251-6. PMID 19773586 DOI: 10.1177/1087057109346446  0.72
2009 Matsuda D, Ohshiro T, Ohba M, Jiang W, Hong B, Si S, Tomoda H. The molecular target of rubimaillin in the inhibition of lipid droplet accumulation in macrophages. Biological & Pharmaceutical Bulletin. 32: 1317-20. PMID 19652367 DOI: JST.JSTAGE/bpb/32.1317  0.56
2009 Bao Y, Yang Y, Wang L, Gao L, Jiang W, Wang L, Si S, Hong B. Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells. Atherosclerosis. 204: 127-35. PMID 18930459 DOI: 10.1016/j.atherosclerosis.2008.08.041  0.56
2008 Chen C, Si S, He Q, Xu H, Lu M, Xie Y, Wang Y, Chen R. Isolation and characterization of antibiotic NC0604, a new analogue of bleomycin. The Journal of Antibiotics. 61: 747-51. PMID 19194033 DOI: 10.1038/ja.2008.88  0.68
2008 Gao J, Xu Y, Yang Y, Yang Y, Zheng Z, Jiang W, Hong B, Yan X, Si S. Identification of upregulators of human ATP-binding cassette transporter A1 via high-throughput screening of a synthetic and natural compound library. Journal of Biomolecular Screening. 13: 648-56. PMID 18594022 DOI: 10.1177/1087057108320545  0.56
2008 Matsuda D, Ohte S, Ohshiro T, Jiang W, Rudel L, Hong B, Si S, Tomoda H. Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages. Biological & Pharmaceutical Bulletin. 31: 1063-6. PMID 18520030 DOI: JST.JSTAGE/bpb/31.1063  0.56
2008 Xie Y, Xu H, Si S, Sun C, Chen R. Sansanmycins B and C, new components of sansanmycins. The Journal of Antibiotics. 61: 237-40. PMID 18503203 DOI: 10.1038/ja.2008.34  0.68
2007 Li Y, Liang F, Jiang W, Yu F, Cao R, Ma Q, Dai X, Jiang J, Wang Y, Si S. DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biology & Therapy. 6: 1193-9. PMID 17622795  0.56
2007 Xie Y, Chen R, Si S, Sun C, Xu H. A new nucleosidyl-peptide antibiotic, sansanmycin. The Journal of Antibiotics. 60: 158-61. PMID 17420567 DOI: 10.1038/ja.2007.16  0.68
2007 Yang Y, Zhang Z, Jiang W, Gao L, Zhao G, Zheng Z, Wang M, Si S, Hong B. Identification of novel human high-density lipoprotein receptor Up-regulators using a cell-based high-throughput screening assay. Journal of Biomolecular Screening. 12: 211-9. PMID 17259591 DOI: 10.1177/1087057106297568  0.56
2004 Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J, Wang Y, Li Z, Liu J, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine. 10: 1344-51. PMID 15531889 DOI: 10.1038/nm1135  0.56
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