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Ashani Weeraratna - Publications

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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Goyal Y, Busch GT, Pillai M, Li J, Boe RH, Grody EI, Chelvanambi M, Dardani IP, Emert B, Bodkin N, Braun J, Fingerman D, Kaur A, Jain N, Ravindran PT, ... ... Weeraratna AT, et al. Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells. Nature. PMID 37468627 DOI: 10.1038/s41586-023-06342-8  0.637
2023 Alicea GM, Portuallo ME, Patel P, Fane ME, Carey AE, Speicher D, Tang HY, Kossenkov AV, Rebecca VW, Wirtz DG, Weeraratna AT. Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis. Biorxiv : the Preprint Server For Biology. PMID 37205503 DOI: 10.1101/2023.05.02.539059  0.352
2023 Fane ME, Ecker BL, Kaur A, Marino GE, Alicea GM, Douglass SM, Chhabra Y, Webster MR, Marshall A, Colling R, Espinosa O, Coupe N, Maroo N, Campo L, Middleton MR, ... ... Weeraratna AT, et al. Correction: sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 29: 2012. PMID 37183634 DOI: 10.1158/1078-0432.CCR-23-0871  0.521
2022 Dardani I, Emert BL, Goyal Y, Jiang CL, Kaur A, Lee J, Rouhanifard SH, Alicea GM, Fane ME, Xiao M, Herlyn M, Weeraratna AT, Raj A. ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ. Nature Methods. PMID 36280724 DOI: 10.1038/s41592-022-01653-6  0.567
2022 Fane ME, Chhabra Y, Alicea GM, Maranto DA, Douglass SM, Webster MR, Rebecca VW, Marino GE, Almeida F, Ecker BL, Zabransky DJ, Hüser L, Beer T, Tang HY, Kossenkov A, ... ... Weeraratna AT, et al. Stromal changes in the aged lung induce an emergence from melanoma dormancy. Nature. PMID 35650435 DOI: 10.1038/s41586-022-04774-2  0.359
2021 Erbe R, Wang Z, Wu S, Xiu J, Zaidi N, La J, Tuck D, Fillmore N, Giraldo NA, Topper M, Baylin S, Lippman M, Isaacs C, Basho R, Serebriiskii I, ... ... Weeraratna A, et al. Evaluating the impact of age on immune checkpoint therapy biomarkers. Cell Reports. 36: 109599. PMID 34433020 DOI: 10.1016/j.celrep.2021.109599  0.308
2021 Torre EA, Arai E, Bayatpour S, Jiang CL, Beck LE, Emert BL, Shaffer SM, Mellis IA, Fane ME, Alicea GM, Budinich KA, Weeraratna AT, Shi J, Raj A. Genetic screening for single-cell variability modulators driving therapy resistance. Nature Genetics. PMID 33398196 DOI: 10.1038/s41588-020-00749-z  0.551
2020 Fane ME, Ecker BL, Kaur A, Marino GE, Alicea GM, Douglass SM, Chhabra Y, Webster MR, Marshall A, Colling R, Espinosa O, Coupe N, Maroo N, Campo L, Middleton MR, ... ... Weeraratna AT, et al. sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33097493 DOI: 10.1158/1078-0432.CCR-20-0446  0.553
2020 Alicea GM, Rebecca VW, Goldman AR, Fane ME, Douglass SM, Behera R, Webster MR, Kugel CH, Ecker BL, Caino MC, Kossenkov AV, Tang HY, Frederick DT, Flaherty KT, Xu X, ... ... Weeraratna AT, et al. Changes in Aged Fibroblast Lipid Metabolism Induce Age-dependent Melanoma Cell Resistance to Targeted Therapy Via the Fatty Acid Transporter FATP2. Cancer Discovery. PMID 32499221 DOI: 10.1158/2159-8290.Cd-20-0329  0.323
2020 Webster MR, Fane ME, Alicea GM, Basu S, Kossenkov AV, Marino GE, Douglass SM, Kaur A, Ecker BL, Gnanapradeepan K, Ndoye A, Kugel C, Valiga A, Palmer J, Liu Q, ... ... Weeraratna AT, et al. Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. Molecular Cell. 77: 681. PMID 32032511 DOI: 10.1016/J.Molcel.2020.01.005  0.517
2020 Fane M, Douglass S, Alicea G, Webster M, Aguirre-Ghiso J, Weeraratna A. Abstract 6107: Stromal and immune changes in the aged lung microenvironment create a permissive niche for the metastatic outgrowth of melanoma Cancer Research. 80: 6107-6107. DOI: 10.1158/1538-7445.Am2020-6107  0.368
2020 Alicea GM, Rebecca VW, Goldman A, Fane M, Behera R, Webster M, Ecker B, Blair I, Speicher D, Schug Z, Weeraratna A. Abstract 5086: The aged tumor microenvironment promotes melanoma metabolic plasticity and therapy Tumor Biology. DOI: 10.1158/1538-7445.Am2020-5086  0.381
2019 Fane M, Weeraratna AT. How the ageing microenvironment influences tumour progression. Nature Reviews. Cancer. PMID 31836838 DOI: 10.1038/s41568-019-0222-9  0.331
2019 Webster MR, Fane ME, Alicea GM, Basu S, Kossenkov AV, Marino GE, Douglass SM, Kaur A, Ecker BL, Gnanapradeepan K, Ndoye A, Kugel C, Valiga A, Palmer J, Liu Q, ... ... Weeraratna AT, et al. Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma. Molecular Cell. PMID 31836388 DOI: 10.1016/J.Molcel.2019.11.009  0.586
2019 Fane M, Weeraratna AT. Normal Aging and Its Role in Cancer Metastasis. Cold Spring Harbor Perspectives in Medicine. PMID 31615864 DOI: 10.1101/cshperspect.a037341  0.336
2018 Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker B, Yang R, Feltcher C, Peng K, Feng C, ... ... Weeraratna A, et al. Loss of Phd2 cooperates with BRAF to drive melanomagenesis. Nature Communications. 9: 5426. PMID 30575721 DOI: 10.1038/S41467-018-07126-9  0.366
2018 Alves-Fernandes DK, de Oliveira ÉA, Faião-Flores F, Alicea-Rebecca G, Weeraratna AT, Smalley KSM, de Moraes Barros SB, Stuchi Maria-Engler S. ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC). Pharmacological Research. PMID 30550954 DOI: 10.1016/j.phrs.2018.12.006  0.336
2018 Kaur A, Ecker BL, Douglass SM, Kugel CH, Webster MR, Almeida FV, Somasundaram R, Hayden J, Ban E, Ahmadzadeh H, Franco-Barraza J, Shah N, Mellis IA, Keeney F, Kossenkov A, ... ... Weeraratna AT, et al. Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility. Cancer Discovery. PMID 30279173 DOI: 10.1158/2159-8290.Cd-18-0193  0.666
2018 Ecker BL, Kaur A, Douglass SM, Webster MR, Almeida FV, Marino G, Sinnamon AJ, Neuwirth MG, Alicea GM, Ndoye A, Fane M, Xu X, Sim MS, Deutsch GB, Faries MB, ... ... Weeraratna AT, et al. Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis. Cancer Discovery. PMID 30279172 DOI: 10.1158/2159-8290.Cd-18-0168  0.552
2018 Almeida FV, Douglass SM, Fane ME, Weeraratna AT. Bad Company: Microenvironmentally Mediated Resistance to Targeted Therapy in Melanoma. Pigment Cell & Melanoma Research. PMID 30216694 DOI: 10.1111/pcmr.12736  0.328
2018 Kugel CH, Douglass SM, Webster MR, Kaur A, Liu Q, Yin X, Weiss SA, Darvishian F, Al-Rohil RN, Ndoye A, Behera R, Alicea GM, Ecker BL, Fane M, Allegrezza MJ, ... ... Weeraratna AT, et al. Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29898988 DOI: 10.1158/1078-0432.Ccr-18-1116  0.535
2018 Echevarría-Vargas IM, Reyes-Uribe PI, Guterres AN, Yin X, Kossenkov AV, Liu Q, Zhang G, Krepler C, Cheng C, Wei Z, Somasundaram R, Karakousis G, Xu W, Morrissette JJ, Lu Y, ... ... Weeraratna AT, et al. Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. Embo Molecular Medicine. PMID 29650805 DOI: 10.15252/Emmm.201708446  0.301
2018 Webster MR, Fane M, Kaur A, Alicea G, Ecker BL, Ndoye A, Kugel C, Basu S, Valiga A, Appleton JL, Murphy ME, Weeraratna A. Abstract 993: Wnt-er is coming: WNT5A promotes a slow cycling phenotype via p53 in conditions of stress Tumor Biology. DOI: 10.1158/1538-7445.Am2018-993  0.494
2017 Ndoye A, Budina-Kolomets A, Kugel CH, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Vashisht Gopal YN, Davies MA, Mills GB, Xu X, Wu H, ... ... Weeraratna AT, et al. ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma. Cancer Research. PMID 28887323 DOI: 10.1158/0008-5472.Can-17-0907  0.562
2017 Behera R, Kaur A, Webster MR, Kim S, Ndoye A, Kugel CH, Alicea GM, Wang JX, Ghosh K, Cheng PF, Lisanti S, Marchbank K, Dang V, Levesque MP, Dummer R, ... ... Weeraratna AT, et al. Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28232477 DOI: 10.1158/1078-0432.Ccr-17-0201  0.629
2016 Kaur A, Webster MR, Weeraratna AT. In the Wnt-er of life: Wnt signalling in melanoma and ageing. British Journal of Cancer. PMID 27764844 DOI: 10.1038/Bjc.2016.332  0.559
2016 Ndoye A, Weeraratna AT. Autophagy- An emerging target for melanoma therapy. F1000research. 5. PMID 27583134 DOI: 10.12688/f1000research.8347.1  0.331
2016 Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, ... ... Weeraratna AT, et al. Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. PMID 27383789 DOI: 10.1038/Nature18939  0.513
2016 Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, ... ... Weeraratna A, et al. The state of melanoma: challenges and opportunities. Pigment Cell & Melanoma Research. PMID 27087480 DOI: 10.1111/Pcmr.12475  0.315
2016 Zhang G, Frederick DT, Wu L, Wei Z, Krepler C, Srinivasan S, Chae YC, Xu X, Choi H, Dimwamwa E, Ope O, Shannan B, Basu D, Zhang D, Guha M, ... ... Weeraratna A, et al. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. The Journal of Clinical Investigation. PMID 27043285 DOI: 10.1172/Jci82661  0.381
2016 Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, ... ... Weeraratna AT, et al. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. PMID 27042933 DOI: 10.1038/Nature17392  0.636
2015 Webster MR, Kugel C, Weeraratna AT. The Wnts of change: How Wnts regulate phenotype switching in melanoma. Biochimica Et Biophysica Acta. PMID 26546268 DOI: 10.1016/j.bbcan.2015.10.002  0.345
2015 Webster MR, Xu M, Kinzler KA, Kaur A, Appleton J, O'Connell MP, Marchbank K, Valiga A, Dang VM, Perego M, Zhang G, Slipicevic A, Keeney F, Lehrmann E, Wood W, ... ... Weeraratna AT, et al. Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells. Pigment Cell & Melanoma Research. 28: 184-95. PMID 25407936 DOI: 10.1111/Pcmr.12330  0.58
2015 Behera R, Marchbank K, Kaur A, Dang V, Webster M, O'Connell M, Xu X, Weeraratna A. Abstract A11: Crosstalk between klotho and wnt5A drives age-related melanoma progression Cancer Research. 75. DOI: 10.1158/1538-7445.Mel2014-A11  0.63
2015 Kaur A, Marchbank K, Dang V, O'Connell M, Webster M, Appleton J, Cheng P, Valiga A, Morissette R, McDonnell N, Ferrucci L, Kossenkov A, Meeth K, Bosenberg M, Tang H, ... ... Weeraratna A, et al. Abstract A04: Aging microenvironment modulates melanoma invasion and metastasis Cancer Research. 75. DOI: 10.1158/1538-7445.Mel2014-A04  0.649
2015 Kaur A, O'Connell M, Webster M, Behera R, Dang V, Ndoye A, Weeraratna A. Abstract 5092: Midkine as a potential target for combating drug resistance and invasion in melanoma Cancer Research. 75: 5092-5092. DOI: 10.1158/1538-7445.Am2015-5092  0.634
2015 Fukunaga-Kalabis M, Hristova D, Wang J, Li L, Heppt M, Wei Z, Gyurdieva A, Webster M, Oka M, Weeraratna A, Herlyn M. Abstract 1508: UV-induced Wnt7a in the human skin microenvironment specifies the fate of neural crest -like cells via suppression of Notch Cancer Research. 75: 1508-1508. DOI: 10.1158/1538-7445.Am2015-1508  0.318
2013 O'Connell MP, Marchbank K, Webster MR, Valiga AA, Kaur A, Vultur A, Li L, Herlyn M, Villanueva J, Liu Q, Yin X, Widura S, Nelson J, Ruiz N, Camilli TC, ... ... Weeraratna AT, et al. Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2. Cancer Discovery. 3: 1378-93. PMID 24104062 DOI: 10.1158/2159-8290.Cd-13-0005  0.597
2013 Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O'Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC. Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. The Journal of Clinical Investigation. 123: 2907-20. PMID 23921130 DOI: 10.1172/Jci67841  0.366
2013 Hooper R, Kedra J, Weeraratna A, Soboloff J. Aberrant Store-Operated Calcium Entry (SOCE) in Invasive Melanoma Biophysical Journal. 104: 101a. DOI: 10.1016/J.Bpj.2012.11.593  0.409
2012 Sharma BK, Manglik V, O'Connell M, Weeraratna A, McCarron EC, Broussard JN, Divito KA, Simbulan-Rosenthal CM, Rosenthal DS, Zapas JL. Clonal dominance of CD133+ subset population as risk factor in tumor progression and disease recurrence of human cutaneous melanoma. International Journal of Oncology. 41: 1570-6. PMID 22922842 DOI: 10.3892/Ijo.2012.1590  0.306
2011 Camilli TC, Xu M, O'Connell MP, Chien B, Frank BP, Subaran S, Indig FE, Morin PJ, Hewitt SM, Weeraratna AT. Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell & Melanoma Research. 24: 175-86. PMID 20955350 DOI: 10.1111/j.1755-148X.2010.00792.x  0.355
2011 Brooks BR, Yin H, Chow D, Sereduk C, Koeman J, Qian C, MacKeigan JP, Jung S, Kim S, Xu M, Weeraratna A, Brown KM, Trent J. Abstract 4984: Association ofPTENandp16mutational status withMITFexpression may provide a novel context for a phenotype switch in melanoma Cancer Research. 71: 4984-4984. DOI: 10.1158/1538-7445.Am2011-4984  0.381
2010 Hersey P, Smalley KS, Weeraratna A, Bosenberg M, Zhang XD, Haass NK, Paton E, Mann G, Scolyer RA, Tüting T. Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010. Pigment Cell & Melanoma Research. 24: e1-15. PMID 21232023 DOI: 10.1111/J.1755-148X.2010.00811.X  0.314
2009 Mello Coelho Vd, Bunbury A, Rangel LB, Giri B, Weeraratna A, Morin PJ, Bernier M, Taub DD. Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytes. International Journal of Medical Sciences. 7: 1-14. PMID 20046229 DOI: 10.7150/Ijms.7.1  0.399
2009 O'Connell MP, Fiori JL, Kershner EK, Frank BP, Indig FE, Taub DD, Hoek KS, Weeraratna AT. Heparan sulfate proteoglycan modulation of Wnt5A signal transduction in metastatic melanoma cells. The Journal of Biological Chemistry. 284: 28704-12. PMID 19696445 DOI: 10.1074/jbc.M109.028498  0.319
2007 Leotlela PD, Wade MS, Duray PH, Rhode MJ, Brown HF, Rosenthal DT, Dissanayake SK, Earley R, Indig FE, Nickoloff BJ, Taub DD, Kallioniemi OP, Meltzer P, Morin PJ, Weeraratna AT. Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility Oncogene. 26: 3846-3856. PMID 17160014 DOI: 10.1038/Sj.Onc.1210155  0.303
2006 Leotlela P, Wade M, Duray P, Rhode M, Dissanayake S, Nickoloff B, Taub D, Meltzer P, Morin P, Weeraratna A. Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility Melanoma Research. 16: S25. DOI: 10.1097/00008390-200609001-00042  0.401
2006 Dissanayake S, Rosenthal D, Hewitt K, Yang S, Wade M, Taub D, Nickoloff B, Trent J, Bittner M, Riker A, Weeraratna A. F.113. Wnt5a Regulates Melanoma Antigen Recognized By T-Cells-1 (Mart-1), a Predominant Antigen in Melanoma Cells Clinical Immunology. 119: S90. DOI: 10.1016/J.Clim.2006.04.153  0.324
2002 Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent JM. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma Cancer Cell. 1: 279-288. PMID 12086864 DOI: 10.1016/S1535-6108(02)00045-4  0.314
2002 Pinski J, Weeraratna A, Uzgare AR, Arnold JT, Denmeade SR, Isaacs JT. Trk receptor inhibition induces apoptosis of proliferating but not quiescent human osteoblasts. Cancer Research. 62: 986-9. PMID 11861369  0.49
2000 Weeraratna AT, Arnold JT, George DJ, DeMarzo A, Isaacs JT. Rational basis for Trk inhibition therapy for prostate cancer. The Prostate. 45: 140-8. PMID 11027413 DOI: 10.1002/1097-0045(20001001)45:2<140::Aid-Pros8>3.0.Co;2-#  0.481
2000 Tombal B, Weeraratna AT, Denmeade SR, Isaacs JT. Thapsigargin induces a calmodulin/calcineurin-dependent apoptotic cascade responsible for the death of prostatic cancer cells Prostate. 43: 303-317. PMID 10861750 DOI: 10.1002/1097-0045(20000601)43:4<303::Aid-Pros10>3.0.Co;2-V  0.453
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