| Year |
Citation |
Score |
| 2021 |
Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, ... ... Segal DJ, et al. The NIH Somatic Cell Genome Editing program. Nature. 592: 195-204. PMID 33828315 DOI: 10.1038/s41586-021-03191-1 |
0.51 |
|
| 2020 |
Teh CE, Gong JN, Segal D, Tan T, Vandenberg CJ, Fedele PL, Low MSY, Grigoriadis G, Harrison SJ, Strasser A, Roberts AW, Huang DCS, Nolan GP, Gray DHD, Ko ME. Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells. Cell Death and Differentiation. PMID 31988495 DOI: 10.1038/S41418-020-0498-Z |
0.306 |
|
| 2019 |
Lee EF, Harris TJ, Tran S, Evangelista M, Arulananda S, John T, Ramnac C, Hobbs C, Zhu H, Gunasingh G, Segal D, Behren A, Cebon J, Dobrovic A, Mariadason JM, et al. BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival. Cell Death & Disease. 10: 342. PMID 31019203 DOI: 10.1038/S41419-019-1568-3 |
0.344 |
|
| 2018 |
Moujalled DM, Pomilio G, Ghiurau C, Ivey A, Salmon J, Rijal S, Macraild S, Zhang L, Teh TC, Tiong IS, Lan P, Chanrion M, Claperon A, Rocchetti F, Zichi A, ... ... Segal D, et al. Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia. Leukemia. PMID 30214012 DOI: 10.1038/S41375-018-0261-3 |
0.31 |
|
| 2018 |
Ha DT, Ghosh S, Ahn CH, Segal DJ, Kim MS. Pathogen-specific DNA sensing with engineered zinc finger proteins immobilized on a polymer chip. The Analyst. PMID 30043772 DOI: 10.1039/C8An00395E |
0.302 |
|
| 2018 |
O'Geen H, Ren C, Coggins NB, Bates SL, Segal DJ. Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators. Plos One. 13: e0193818. PMID 29584750 DOI: 10.1371/journal.pone.0193818 |
0.343 |
|
| 2018 |
Gallego-Bartolomé J, Gardiner J, Liu W, Papikian A, Ghoshal B, Kuo HY, Zhao JM, Segal DJ, Jacobsen SE. Targeted DNA demethylation of thegenome using the human TET1 catalytic domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 29444862 DOI: 10.1073/Pnas.1716945115 |
0.305 |
|
| 2017 |
Sharp PP, Garnier JM, Hatfaludi T, Xu Z, Segal D, Jarman KE, Jousset H, Garnham A, Feutrill JT, Cuzzupe A, Hall P, Taylor S, Walkley CR, Tyler D, Dawson MA, et al. Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors. Acs Medicinal Chemistry Letters. 8: 1298-1303. PMID 29259751 DOI: 10.1021/Acsmedchemlett.7B00389 |
0.341 |
|
| 2017 |
Teh TC, Nguyen NY, Moujalled DM, Segal D, Pomilio G, Rijal S, Jabbour A, Cummins K, Lackovic K, Blombery P, Thompson E, Ekert PG, Lessene G, Glaser SP, Huang DCS, et al. Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1. Leukemia. PMID 28751770 DOI: 10.1038/Leu.2017.243 |
0.347 |
|
| 2017 |
Antignani A, Segal D, Simon N, Kreitman RJ, Huang D, FitzGerald DJ. Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins. Oncogene. PMID 28436946 DOI: 10.1038/Onc.2017.111 |
0.349 |
|
| 2017 |
Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, et al. Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo. Cell Death and Differentiation. PMID 28362427 DOI: 10.1038/Cdd.2017.30 |
0.314 |
|
| 2017 |
Johnson LM, Du J, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. Corrigendum: SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 543: 136. PMID 28178234 DOI: 10.1038/Nature21398 |
0.304 |
|
| 2017 |
De Leon KJ, Antrobus S, Denney Allen P, Marty I, Segal D. A Method for Validating Mutations Associated with Malignant Hyperthermia using CRISPR/Cas9 and Dual Integrase Cassette Exchange Biophysical Journal. 112: 98a. DOI: 10.1016/J.Bpj.2016.11.566 |
0.312 |
|
| 2016 |
Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, ... ... Segal D, et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. PMID 27760111 DOI: 10.1038/Nature19830 |
0.344 |
|
| 2016 |
Gong JN, Khong T, Segal D, Yao Y, Riffkin CD, Garnier JM, Khaw SL, Lessene G, Spencer A, Herold MJ, Roberts AW, Huang DC. Hierarchy for targeting pro-survival BCL2 family proteins in multiple myeloma: pivotal role of MCL1. Blood. PMID 27465916 DOI: 10.1182/Blood-2016-03-704908 |
0.359 |
|
| 2016 |
Xu Z, Sharp PP, Yao Y, Segal D, Ang CH, Khaw SL, Aubrey BJ, Gong J, Kelly GL, Herold MJ, Strasser A, Roberts AW, Alexander WS, Burns CJ, Huang DC, et al. BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia. PMID 27055867 DOI: 10.1038/Leu.2016.52 |
0.345 |
|
| 2016 |
Yao Y, Gong J, Segal D, Riffkin CD, Delft MFv, Roberts AW, Huang DC. The Role of BAX/BAK-Mediated Apoptosis for the Cytotoxic Action of Anti-Myeloma Agents Blood. 128: 5706-5706. DOI: 10.1182/Blood.V128.22.5706.5706 |
0.313 |
|
| 2016 |
Gong J, Khong T, Segal D, Yao Y, Delft MFv, Spencer A, Roberts AW, Huang DC. Targeting the Pro-Survival BCL2 Proteins with BH3 Mimetic Compounds for Treating Multiple Myeloma Blood. 128: 3293-3293. DOI: 10.1182/Blood.V128.22.3293.3293 |
0.356 |
|
| 2015 |
Phillipson LJ, Segal DH, Nero TL, Parker MW, Wan SS, de Silva M, Guthridge MA, Wei AH, Burns CJ. Discovery and SAR of novel pyrazolo[1,5-a]pyrimidines as inhibitors of CDK9. Bioorganic & Medicinal Chemistry. 23: 6280-96. PMID 26349627 DOI: 10.1016/J.Bmc.2015.08.035 |
0.349 |
|
| 2014 |
Rader C, Segal DJ, Shabat D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology. Acs Chemical Biology. 9: 1645-6. PMID 25123302 DOI: 10.1021/Cb5005993 |
0.557 |
|
| 2014 |
Singer R, Atar S, Atias O, Oron E, Segal D, Hirsch JA, Tuller T, Orian A, Chamovitz DA. Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. Nucleic Acids Research. 42: 9761-70. PMID 25106867 DOI: 10.1093/Nar/Gku723 |
0.305 |
|
| 2014 |
Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. Miz-1 activates gene expression via a novel consensus DNA binding motif. Plos One. 9: e101151. PMID 24983942 DOI: 10.1371/Journal.Pone.0101151 |
0.343 |
|
| 2013 |
Owens JB, Mauro D, Stoytchev I, Bhakta MS, Kim MS, Segal DJ, Moisyadi S. Transcription activator like effector (TALE)-directed piggyBac transposition in human cells. Nucleic Acids Research. 41: 9197-207. PMID 23921635 DOI: 10.1093/Nar/Gkt677 |
0.388 |
|
| 2013 |
Thomas D, Powell JA, Vergez F, Segal DH, Nguyen NY, Baker A, Teh TC, Barry EF, Sarry JE, Lee EM, Nero TL, Jabbour AM, Pomilio G, Green BD, Manenti S, et al. Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood. 122: 738-48. PMID 23775716 DOI: 10.1182/Blood-2012-08-447441 |
0.334 |
|
| 2013 |
Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP. New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. The Journal of Biological Chemistry. 288: 10616-27. PMID 23436653 DOI: 10.1074/Jbc.M112.441451 |
0.328 |
|
| 2013 |
Meckler JF, Bhakta MS, Kim MS, Ovadia R, Habrian CH, Zykovich A, Yu A, Lockwood SH, Morbitzer R, Elsäesser J, Lahaye T, Segal DJ, Baldwin EP. Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Research. 41: 4118-28. PMID 23408851 DOI: 10.1093/Nar/Gkt085 |
0.346 |
|
| 2013 |
Burns CJ, Segal D, Wilks AF. The Use of JAK-specific inhibitors as chemical biology tools. Methods in Molecular Biology (Clifton, N.J.). 967: 99-113. PMID 23296724 DOI: 10.1007/978-1-62703-242-1_7 |
0.3 |
|
| 2013 |
Bhakta MS, Henry IM, Ousterout DG, Das KT, Lockwood SH, Meckler JF, Wallen MC, Zykovich A, Yu Y, Leo H, Xu L, Gersbach CA, Segal DJ. Highly active zinc-finger nucleases by extended modular assembly. Genome Research. 23: 530-8. PMID 23222846 DOI: 10.1101/Gr.143693.112 |
0.574 |
|
| 2012 |
Meier JL, Yu AS, Korf I, Segal DJ, Dervan PB. Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. Journal of the American Chemical Society. 134: 17814-22. PMID 23013524 DOI: 10.1021/Ja308888C |
0.316 |
|
| 2012 |
Owens JB, Urschitz J, Stoytchev I, Dang NC, Stoytcheva Z, Belcaid M, Maragathavally KJ, Coates CJ, Segal DJ, Moisyadi S. Chimeric piggyBac transposases for genomic targeting in human cells. Nucleic Acids Research. 40: 6978-91. PMID 22492708 DOI: 10.1093/Nar/Gks309 |
0.319 |
|
| 2011 |
Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry. 50: 5033-41. PMID 21528840 DOI: 10.1021/Bi200393G |
0.321 |
|
| 2011 |
Kim MS, Stybayeva G, Lee JY, Revzin A, Segal DJ. A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications. Nucleic Acids Research. 39: e29. PMID 21134909 DOI: 10.1093/Nar/Gkq1214 |
0.327 |
|
| 2010 |
Furman JL, Badran AH, Ajulo O, Porter JR, Stains CI, Segal DJ, Ghosh I. Toward a general approach for RNA-templated hierarchical assembly of split-proteins. Journal of the American Chemical Society. 132: 11692-701. PMID 20681585 DOI: 10.1021/Ja104395B |
0.301 |
|
| 2009 |
Zykovich A, Korf I, Segal DJ. Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing. Nucleic Acids Research. 37: e151. PMID 19843614 DOI: 10.1093/Nar/Gkp802 |
0.367 |
|
| 2009 |
Shimizu Y, Bhakta MS, Segal DJ. Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker. Bioorganic & Medicinal Chemistry Letters. 19: 3970-2. PMID 19289279 DOI: 10.1016/j.bmcl.2009.02.109 |
0.337 |
|
| 2008 |
Cathomen T, Segal DJ, Brondani V, Müller-Lerch F. Generation and functional analysis of zinc finger nucleases. Methods in Molecular Biology (Clifton, N.J.). 434: 277-90. PMID 18470651 DOI: 10.1007/978-1-60327-248-3_17 |
0.341 |
|
| 2008 |
Brayer KJ, Kulshreshtha S, Segal DJ. The protein-binding potential of C2H2 zinc finger domains. Cell Biochemistry and Biophysics. 51: 9-19. PMID 18286240 DOI: 10.1007/S12013-008-9007-6 |
0.361 |
|
| 2008 |
Brayer KJ, Segal DJ. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Cell Biochemistry and Biophysics. 50: 111-31. PMID 18253864 DOI: 10.1007/S12013-008-9008-5 |
0.312 |
|
| 2007 |
Szczepek M, Brondani V, Büchel J, Serrano L, Segal DJ, Cathomen T. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nature Biotechnology. 25: 786-93. PMID 17603476 DOI: 10.1038/Nbt1317 |
0.354 |
|
| 2007 |
Hartsock WJ, Cohen JD, Segal DJ. Uranyl acetate as a direct inhibitor of DNA-binding proteins. Chemical Research in Toxicology. 20: 784-9. PMID 17432879 DOI: 10.1021/tx600347k |
0.325 |
|
| 2007 |
Gommans WM, McLaughlin PM, Lindhout BI, Segal DJ, Wiegman DJ, Haisma HJ, van der Zaal BJ, Rots MG. Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment. Molecular Carcinogenesis. 46: 391-401. PMID 17186549 DOI: 10.1002/Mc.20289 |
0.364 |
|
| 2006 |
Carroll D, Morton JJ, Beumer KJ, Segal DJ. Design, construction and in vitro testing of zinc finger nucleases. Nature Protocols. 1: 1329-41. PMID 17406419 DOI: 10.1038/Nprot.2006.231 |
0.349 |
|
| 2006 |
Segal DJ, Crotty JW, Bhakta MS, Barbas CF, Horton NC. Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. Journal of Molecular Biology. 363: 405-21. PMID 16963084 DOI: 10.1016/J.Jmb.2006.08.016 |
0.374 |
|
| 2006 |
Ooi AT, Stains CI, Ghosh I, Segal DJ. Sequence-enabled reassembly of beta-lactamase (SEER-LAC): a sensitive method for the detection of double-stranded DNA. Biochemistry. 45: 3620-5. PMID 16533044 DOI: 10.1021/Bi0517032 |
0.32 |
|
| 2006 |
Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. Journal of Virology. 80: 2873-83. PMID 16501096 DOI: 10.1128/Jvi.80.6.2873-2883.2006 |
0.447 |
|
| 2005 |
Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF. Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors. The Journal of Biological Chemistry. 280: 35588-97. PMID 16107335 DOI: 10.1074/jbc.M506654200 |
0.671 |
|
| 2005 |
Stains CI, Porter JR, Ooi AT, Segal DJ, Ghosh I. DNA sequence-enabled reassembly of the green fluorescent protein. Journal of the American Chemical Society. 127: 10782-3. PMID 16076155 DOI: 10.1021/Ja051969W |
0.367 |
|
| 2005 |
Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF, Segal DJ, Weitzman MD, Cathomen T. Custom zinc-finger nucleases for use in human cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 610-7. PMID 16039907 DOI: 10.1016/j.ymthe.2005.06.094 |
0.369 |
|
| 2005 |
Kolb AF, Coates CJ, Kaminski JM, Summers JB, Miller AD, Segal DJ. Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends in Biotechnology. 23: 399-406. PMID 15982766 DOI: 10.1016/J.Tibtech.2005.06.005 |
0.322 |
|
| 2004 |
Blancafort P, Segal DJ, Barbas CF. Designing transcription factor architectures for drug discovery. Molecular Pharmacology. 66: 1361-71. PMID 15340042 DOI: 10.1124/Mol.104.002758 |
0.688 |
|
| 2004 |
Håkansson P, Segal D, Lassen C, Gullberg U, Morse HC, Fioretos T, Meltzer PS. Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays. Experimental Hematology. 32: 476-482. PMID 15145216 DOI: 10.1016/J.Exphem.2004.02.012 |
0.332 |
|
| 2004 |
Segal DJ, Gonçalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF. Attenuation of HIV-1 Replication in Primary Human Cells with a Designed Zinc Finger Transcription Factor Journal of Biological Chemistry. 279: 14509-14519. PMID 14734553 DOI: 10.1074/Jbc.M400349200 |
0.434 |
|
| 2004 |
Tan W, Zhu K, Segal DJ, Barbas CF, Chow SA. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. Journal of Virology. 78: 1301-13. PMID 14722285 DOI: 10.1128/Jvi.78.3.1301-1313.2004 |
0.344 |
|
| 2003 |
Segal DJ, Beerli RR, Blancafort P, Dreier B, Effertz K, Huber A, Koksch B, Lund CV, Magnenat L, Valente D, Barbas CF. Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry. 42: 2137-48. PMID 12590603 DOI: 10.1021/Bi026806O |
0.671 |
|
| 2002 |
Segal DJ. The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment Methods. 26: 76-83. PMID 12054906 DOI: 10.1016/S1046-2023(02)00009-9 |
0.35 |
|
| 2002 |
Segal DJ, Barbas CF. Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Current Opinion in Biotechnology. 12: 632-7. PMID 11849947 DOI: 10.1016/S0958-1669(01)00272-5 |
0.384 |
|
| 2001 |
Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF. Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. The Journal of Biological Chemistry. 276: 29466-78. PMID 11340073 DOI: 10.1074/Jbc.M102604200 |
0.444 |
|
| 2001 |
Bibikova M, Carroll D, Segal DJ, Trautman JK, Smith J, Kim YG, Chandrasegaran S. Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Molecular and Cellular Biology. 21: 289-97. PMID 11113203 DOI: 10.1128/Mcb.21.1.289-297.2001 |
0.351 |
|
| 2000 |
Dreier B, Segal DJ, Barbas CF. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. Journal of Molecular Biology. 303: 489-502. PMID 11054286 DOI: 10.1006/jmbi.2000.4133 |
0.407 |
|
| 2000 |
Barbas CF, Rader C, Segal DJ, List B, Turner JM. From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins. Advances in Protein Chemistry. 55: 317-66. PMID 11050938 DOI: 10.1016/S0065-3233(01)55008-1 |
0.648 |
|
| 2000 |
Segal DJ, Barbas CF. Design of novel sequence-specific DNA-binding proteins. Current Opinion in Chemical Biology. 4: 34-9. PMID 10679372 DOI: 10.1016/S1367-5931(99)00048-4 |
0.445 |
|
| 1999 |
Gabriele L, Phung J, Fukumoto J, Segal D, Wang IM, Giannakakou P, Giese NA, Ozato K, Morse HC. Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein. The Journal of Experimental Medicine. 190: 411-21. PMID 10430629 DOI: 10.1084/Jem.190.3.411 |
0.351 |
|
| 1999 |
Segal DJ, Dreier B, Beerli RR, Barbas CF. Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences. Proceedings of the National Academy of Sciences of the United States of America. 96: 2758-63. PMID 10077584 DOI: 10.1073/pnas.96.6.2758 |
0.422 |
|
| 1999 |
Beerli RR, Segal DJ, Dreier B, Barbas CF. Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proceedings of the National Academy of Sciences of the United States of America. 95: 14628-33. PMID 9843940 DOI: 10.1073/pnas.95.25.14628 |
0.398 |
|
| 1997 |
Liu Q, Segal DJ, Ghiara JB, Barbas CF. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proceedings of the National Academy of Sciences of the United States of America. 94: 5525-30. PMID 9159105 DOI: 10.1073/pnas.94.11.5525 |
0.419 |
|
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