Jayaraj Rajagopal - Publications

Affiliations: 
Center for Regenerative Medicine Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States 

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Waghray A, Monga I, Lin B, Shah V, Slyper M, Giotti B, Xu J, Waldman J, Dionne D, Nguyen LT, Lou W, Cai P, Park E, Muus C, Sun J, ... ... Rajagopal J, et al. A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium. Biorxiv : the Preprint Server For Biology. PMID 38076853 DOI: 10.1101/2023.11.28.569028  0.492
2023 Surve MV, Lin B, Reedy JL, Crossen AJ, Xu A, Klein BS, Vyas JM, Rajagopal J. Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells. American Journal of Respiratory Cell and Molecular Biology. 69: 698-701. PMID 38038398 DOI: 10.1165/rcmb.2023-0292LE  0.415
2023 Surve MV, Lin B, Reedy JL, Crossen AJ, Xu A, Klein BS, Vyas JM, Rajagopal J. Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells. Biorxiv : the Preprint Server For Biology. PMID 37609222 DOI: 10.1101/2023.08.06.552176  0.366
2023 Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, ... ... Rajagopal J, et al. An integrated cell atlas of the lung in health and disease. Nature Medicine. PMID 37291214 DOI: 10.1038/s41591-023-02327-2  0.417
2023 Shah VS, Hou J, Vinarsky V, Xu J, Surve M, Lin CP, Rajagopal J. Autofluorescence imaging permits label free cell type assignment in unmodified airway and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs). Elife. 12. PMID 36994985 DOI: 10.7554/eLife.84375  0.339
2021 Shah VS, Chivukula RR, Lin B, Waghray A, Rajagopal J. Cystic Fibrosis and the Cells of the Airway Epithelium: What Are Ionocytes and What Do They Do? Annual Review of Pathology. PMID 34437820 DOI: 10.1146/annurev-pathol-042420-094031  0.357
2021 Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, ... ... Rajagopal J, et al. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. PMID 33915569 DOI: 10.1038/s41586-021-03570-8  0.365
2021 Mou H, Yang Y, Riehs MA, Barrios J, Shivaraju M, Haber AL, Montoro DT, Gilmore K, Haas EA, Paunovic B, Rajagopal J, Vargas SO, Haynes RL, Fine A, Cardoso WV, et al. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Reports. 35: 109011. PMID 33882306 DOI: 10.1016/j.celrep.2021.109011  0.389
2021 Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, ... ... Rajagopal J, et al. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 33655247 DOI: 10.1101/2021.02.25.430130  0.384
2021 Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science (New York, N.Y.). 371: 52-57. PMID 33384370 DOI: 10.1126/science.aba0629  0.414
2020 Lin D, Lin B, Bhanot H, Riou R, Abt NB, Rajagopal J, Saladi SV. RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers. Oral Oncology. 111: 104930. PMID 32745900 DOI: 10.1016/J.Oraloncology.2020.104930  0.352
2020 Montoro DT, Haber AL, Rood JE, Regev A, Rajagopal J. A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia. Cold Spring Harbor Perspectives in Biology. PMID 32122885 DOI: 10.1101/Cshperspect.A035733  0.457
2020 Ellisen L, Tata PR, Zhao R, Rajagopal J, Saladi SV. Abstract B42: YAP1/Hippo pathway and SWI/SNF as critical players in squamous cancers and normal development Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B42  0.355
2019 Schiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M, Vieira Braga F, Timens W, Koppelman GH, Budinger GRS, Burgess JK, van den Berge M, Theis FJ, Regev A, Kaminski N, ... Rajagopal J, et al. The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease. American Journal of Respiratory Cell and Molecular Biology. PMID 30995076 DOI: 10.1165/Rcmb.2018-0416Tr  0.499
2019 Saladi S, Morris R, Ross K, Karaayvaz m, Tata PR, mou h, Rajagopal J, Lawrence M, Ellisen L. Abstract LB-103: Defining oncogenic SWI/SNF complex mediated immune reprogramming in squamous cell carcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-103  0.406
2018 Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, ... ... Rajagopal J, et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. PMID 30069044 DOI: 10.1038/S41586-018-0393-7  0.522
2018 Causton B, Pardo-Saganta A, Gillis J, Discipio K, Kooistra T, Rajagopal J, Xavier RJ, Cho JL, Medoff BD. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. American Journal of Respiratory Cell and Molecular Biology. PMID 29958012 DOI: 10.1165/Rcmb.2017-0181Oc  0.43
2018 Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J. Modulating Cell Fate as a Therapeutic Strategy. Cell Stem Cell. PMID 29910150 DOI: 10.1016/J.Stem.2018.05.009  0.447
2018 Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, ... ... Rajagopal J, et al. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 22: 779. PMID 29727685 DOI: 10.1016/J.Stem.2018.04.007  0.479
2018 Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, ... ... Rajagopal J, et al. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. PMID 29656941 DOI: 10.1016/J.Stem.2018.03.017  0.543
2018 Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Developmental Cell. 44: 679-693.e5. PMID 29587142 DOI: 10.1016/J.Devcel.2018.02.024  0.472
2018 Taylor MS, Chivukula RR, Myers LC, Jeck WR, Waghray A, Tata PR, Selig MK, O'Donnell WJ, Farver CF, Thompson BT, Rajagopal J, Kradin RL. A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury. The American Journal of Pathology. PMID 29476724 DOI: 10.1016/J.Ajpath.2018.01.021  0.361
2018 Paksa A, Rajagopal J. The epigenetic basis of cellular plasticity. Current Opinion in Cell Biology. 49: 116-122. PMID 29413970 DOI: 10.1016/J.Ceb.2018.01.003  0.464
2017 Yonker LM, Pazos MA, Lanter BB, Mou H, Chu KK, Eaton AD, Bonventre JV, Tearney GJ, Rajagopal J, Hurley BP. Neutrophil-Derived Cytosolic PLA2α Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. Journal of Immunology (Baltimore, Md. : 1950). PMID 28887431 DOI: 10.4049/Jimmunol.1700539  0.338
2017 Yonker LM, Mou H, Chu KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP. Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Scientific Reports. 7: 8182. PMID 28811631 DOI: 10.1038/S41598-017-08567-W  0.359
2017 Waghray A, Rajagopal J. Tips from the embryonic lung. Elife. 6. PMID 28806170 DOI: 10.7554/Elife.30194  0.452
2017 Taylor MS, Chivukula RR, Myers LC, Jeck WR, Tata PR, O'Donnell WJ, Farver CF, Thompson BT, Rajagopal J, Kradin RL. Delayed Alveolar Epithelization: A Distinct Pathology in Diffuse Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine. PMID 28696778 DOI: 10.1164/Rccm.201706-1094Le  0.309
2017 Tata PR, Rajagopal J. Plasticity in the lung: making and breaking cell identity. Development (Cambridge, England). 144: 755-766. PMID 28246210 DOI: 10.1242/Dev.143784  0.499
2016 Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. PMID 28041841 DOI: 10.1016/J.Ccell.2016.12.001  0.384
2016 Tata PR, Rajagopal J. Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny. Cell Stem Cell. 19: 686-689. PMID 27912089 DOI: 10.1016/J.Stem.2016.11.009  0.452
2016 Tata PR, Rajagopal J. Cellular plasticity: 1712 to the present day. Current Opinion in Cell Biology. 43: 46-54. PMID 27485353 DOI: 10.1016/J.Ceb.2016.07.005  0.495
2016 Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, ... ... Rajagopal J, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. PMID 27320041 DOI: 10.1016/J.Stem.2016.05.012  0.513
2016 Rajagopal J, Stanger BZ. Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues? Developmental Cell. 36: 133-7. PMID 26812013 DOI: 10.1016/J.Devcel.2015.12.021  0.324
2015 Mou H, Brazauskas K, Rajagopal J. Personalized medicine for cystic fibrosis: establishing human model systems. Pediatric Pulmonology. 50: S14-23. PMID 26335952 DOI: 10.1002/Ppul.23233  0.449
2015 Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, et al. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Bioscience Reports. 35. PMID 26182382 DOI: 10.1042/Bsr20150004  0.371
2015 Pardo-Saganta A, Tata PR, Law BM, Saez B, Chow RDz, Prabhu M, Gridley T, Rajagopal J. Parent stem cells can serve as niches for their daughter cells. Nature. 523: 597-601. PMID 26147083 DOI: 10.1038/Nature14553  0.518
2015 Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. Journal of Immunology (Baltimore, Md. : 1950). 195: 683-94. PMID 26041536 DOI: 10.4049/Jimmunol.1402983  0.387
2015 Dowdall JR, Sadow PM, Hartnick C, Vinarsky V, Mou H, Zhao R, Song PC, Franco RA, Rajagopal J. Identification of distinct layers within the stratified squamous epithelium of the adult human true vocal fold. The Laryngoscope. PMID 25988619 DOI: 10.1002/Lary.25264  0.327
2015 Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. The Journal of Experimental Medicine. 212: 759-74. PMID 25918341 DOI: 10.1084/Jem.20141843  0.399
2015 Pardo-Saganta A, Law BM, Tata PR, Villoria J, Saez B, Mou H, Zhao R, Rajagopal J. Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. Cell Stem Cell. 16: 184-97. PMID 25658372 DOI: 10.1016/J.Stem.2015.01.002  0.535
2014 Gilpin SE, Ren X, Okamoto T, Guyette JP, Mou H, Rajagopal J, Mathisen DJ, Vacanti JP, Ott HC. Enhanced lung epithelial specification of human induced pluripotent stem cells on decellularized lung matrix. The Annals of Thoracic Surgery. 98: 1721-9; discussion 1. PMID 25149047 DOI: 10.1016/J.Athoracsur.2014.05.080  0.475
2014 Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Developmental Cell. 30: 151-65. PMID 25043474 DOI: 10.1016/J.Devcel.2014.06.004  0.498
2014 Guha A, Vasconcelos M, Zhao R, Gower AC, Rajagopal J, Cardoso WV. Analysis of Notch signaling-dependent gene expression in developing airways reveals diversity of Clara cells. Plos One. 9: e88848. PMID 24586412 DOI: 10.1371/Journal.Pone.0088848  0.475
2013 Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature. 503: 218-23. PMID 24196716 DOI: 10.1038/Nature12777  0.513
2013 Tata PR, Pardo-Saganta A, Prabhu M, Vinarsky V, Law BM, Fontaine BA, Tager AM, Rajagopal J. Airway-specific inducible transgene expression using aerosolized doxycycline. American Journal of Respiratory Cell and Molecular Biology. 49: 1048-56. PMID 23848320 DOI: 10.1165/Rcmb.2012-0412Oc  0.4
2013 Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, ... Rajagopal J, et al. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes & Development. 27: 197-210. PMID 23322301 DOI: 10.1101/Gad.203208.112  0.453
2013 Pardo-Saganta A, Law BM, Gonzalez-Celeiro M, Vinarsky V, Rajagopal J. Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge. American Journal of Respiratory Cell and Molecular Biology. 48: 364-73. PMID 23239495 DOI: 10.1165/Rcmb.2012-0146Oc  0.516
2013 Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, Rajagopal J, et al. Abstract 3127: Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Cancer Research. 73: 3127-3127. DOI: 10.1158/1538-7445.Am2013-3127  0.454
2012 Kim JK, Vinarsky V, Wain J, Zhao R, Jung K, Choi J, Lam A, Pardo-Saganta A, Breton S, Rajagopal J, Yun SH. In vivo imaging of tracheal epithelial cells in mice during airway regeneration. American Journal of Respiratory Cell and Molecular Biology. 47: 864-8. PMID 22984086 DOI: 10.1165/Rcmb.2012-0164Oc  0.478
2012 Longmire TA, Ikonomou L, Hawkins F, Christodoulou C, Cao Y, Jean JC, Kwok LW, Mou H, Rajagopal J, Shen SS, Dowton AA, Serra M, Weiss DJ, Green MD, Snoeck HW, et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 10: 398-411. PMID 22482505 DOI: 10.1016/J.Stem.2012.01.019  0.523
2012 Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 10: 385-97. PMID 22482504 DOI: 10.1016/J.Stem.2012.01.018  0.754
2010 Chen S, Rajagopal J, Zhou Q, Melton DA, Koh A, Senior P, Shapiro AMJ, Barbu AR, Welsh N. Other Future Directions Textbook of Diabetes: Fourth Edition. 1045-1069. DOI: 10.1002/9781444324808.ch61  0.39
2009 Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (Cambridge, England). 136: 1751-9. PMID 19369400 DOI: 10.1242/Dev.029249  0.758
2008 Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 455: 627-32. PMID 18754011 DOI: 10.1038/Nature07314  0.74
2008 Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (Cambridge, England). 135: 1625-34. PMID 18367557 DOI: 10.1242/Dev.015495  0.74
2008 Anderson WJ, Zhou Q, Alcalde V, Kaneko OF, Blank LJ, Sherwood RI, Guseh JS, Rajagopal J, Melton DA. Genetic targeting of the endoderm with claudin-6CreER. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 504-12. PMID 18213590 DOI: 10.1002/Dvdy.21437  0.737
2007 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA. A multipotent progenitor domain guides pancreatic organogenesis. Developmental Cell. 13: 103-14. PMID 17609113 DOI: 10.1016/J.Devcel.2007.06.001  0.728
2007 Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes & Development. 21: 694-707. PMID 17369402 DOI: 10.1101/Gad.1526207  0.344
2007 Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Developmental Cell. 12: 113-27. PMID 17199045 DOI: 10.1016/J.Devcel.2006.11.003  0.393
2004 Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MCO, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P. Artifactual insulin release from differentiated embryonic stem cells Diabetes. 53: 2603-2609. PMID 15448090 DOI: 10.2337/Diabetes.53.10.2603  0.579
2003 Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science (New York, N.Y.). 299: 363. PMID 12532008 DOI: 10.1126/science.1077838  0.601
2000 Rajagopal J, Kinane TB. Is there more to lung development than steroids and surfactant? Pediatrics. 106: 1103-4. PMID 11061782 DOI: 10.1542/Peds.106.5.1103  0.394
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