Amanda Sierra, PhD - Publications

Affiliations: 
2000-2004 Cajal Institute, Madrid, Spain 
 2004-2006 Rockefeller University, New York, NY, United States 
 2006-2008 Stony Brook University, Stony Brook, NY, United States 
 2008-2011 Baylor College of Medicine/Jan and Dan Duncan Neurological Research Institute 
 2011- Glial Cell Biology Lab Achucarro Basque Center for Neuroscience 
Area:
Microglia, phagocytosis, inflammation, diseases, development, adult neurogenesis
Website:
https://www.achucarro.org/es/people/amanda-sierra-saavedra

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Beccari S, Sierra-Torre V, Valero J, Pereira-Iglesias M, García-Zaballa M, Soria FN, De Las Heras-Garcia L, Carretero-Guillen A, Capetillo-Zarate E, Domercq M, Huguet PR, Ramonet D, Osman A, Han W, Dominguez C, ... ... Sierra A, et al. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy. Autophagy. PMID 36622892 DOI: 10.1080/15548627.2023.2165313  0.306
2020 Sierra-Torre V, Plaza-Zabala A, Bonifazi P, Abiega O, Díaz-Aparicio I, Tegelberg S, Lehesjoki AE, Valero J, Sierra A. Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy. Epilepsia. PMID 32940364 DOI: 10.1111/Epi.16692  0.305
2020 Diaz-Aparicio I, Paris I, Sierra-Torre V, Plaza-Zabala A, Rodríguez-Iglesias N, Márquez-Ropero M, Beccari S, Huguet P, Abiega O, Alberdi E, Matute C, Bernales I, Schulz A, Otrokocsi L, Sperlagh B, ... ... Sierra A, et al. Microglia actively remodel adult hippocampal neurogenesis through the phagocytosis secretome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31896673 DOI: 10.1523/Jneurosci.0993-19.2019  0.681
2019 Muro-García T, Martín-Suárez S, Espinosa N, Valcárcel-Martín R, Marinas A, Zaldumbide L, Galbarriatu L, Sierra A, Fuentealba P, Encinas JM. Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala. Frontiers in Cell and Developmental Biology. 7: 158. PMID 31482091 DOI: 10.3389/Fcell.2019.00158  0.381
2019 Rodríguez-Iglesias N, Sierra A, Valero J. Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia. Frontiers in Cell and Developmental Biology. 7: 24. PMID 30891446 DOI: 10.3389/fcell.2019.00024  0.305
2019 Sierra A, Denes A. Editorial: Microglia-Neuron. Neuroscience. PMID 30731154 DOI: 10.1016/j.neuroscience.2019.01.052  0.32
2017 Beccari S, Valero J, Maletic-Savatic M, Sierra A. A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis. Scientific Reports. 7: 16528. PMID 29184142 DOI: 10.1038/s41598-017-16466-3  0.648
2017 Li B, Sierra A, Deudero JJ, Semerci F, Laitman A, Kimmel M, Maletic-Savatic M. Multitype Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis. Bmc Systems Biology. 11: 90. PMID 28984196 DOI: 10.1186/S12918-017-0468-3  0.651
2017 Bielefeld P, Sierra A, Encinas JM, Maletic-Savatic M, Anderson A, Fitzsimons CP. A Standardized Protocol for Stereotaxic Intrahippocampal Administration of Kainic Acid Combined with Electroencephalographic Seizure Monitoring in Mice. Frontiers in Neuroscience. 11: 160. PMID 28405182 DOI: 10.3389/Fnins.2017.00160  0.581
2017 Plaza-Zabala A, Sierra-Torre V, Sierra A. Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging. International Journal of Molecular Sciences. 18. PMID 28282924 DOI: 10.3390/ijms18030598  0.31
2017 Askew K, Li K, Olmos-Alonso A, Garcia-Moreno F, Liang Y, Richardson P, Tipton T, Chapman MA, Riecken K, Beccari S, Sierra A, Molnár Z, Cragg MS, Garaschuk O, Perry VH, et al. Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain. Cell Reports. 18: 391-405. PMID 28076784 DOI: 10.1016/J.Celrep.2016.12.041  0.3
2016 Diaz-Aparicio I, Beccari S, Abiega O, Sierra A. Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain. Neural Regeneration Research. 11: 1533-1539. PMID 27904472 DOI: 10.4103/1673-5374.193220  0.341
2016 Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, ... ... Sierra A, et al. Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. Plos Biology. 14: e1002554. PMID 27649285 DOI: 10.1371/journal.pbio.1002554  0.65
2016 Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, ... ... Sierra A, et al. Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. Plos Biology. 14: e1002508. PMID 27362865 DOI: 10.1371/journal.pbio.1002508  0.65
2016 Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, ... ... Sierra A, et al. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. Plos Biology. 14: e1002466. PMID 27228556 DOI: 10.1371/Journal.Pbio.1002466  0.667
2016 Valero J, Paris I, Sierra A. Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis. Acs Chemical Neuroscience. 7: 442-53. PMID 26971802 DOI: 10.1021/acschemneuro.6b00009  0.343
2015 Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maleti?-Savati? M, Encinas JM. Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis. Cell Stem Cell. 16: 488-503. PMID 25957904 DOI: 10.1016/J.Stem.2015.04.003  0.383
2015 Tremblay MÈ, Lecours C, Samson L, Sánchez-Zafra V, Sierra A. From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia. Frontiers in Neuroanatomy. 9: 45. PMID 25926775 DOI: 10.3389/Fnana.2015.00045  0.362
2014 Sierra A, Beccari S, Diaz-Aparicio I, Encinas JM, Comeau S, Tremblay MÈ. Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis. Neural Plasticity. 2014: 610343. PMID 24772353 DOI: 10.1155/2014/610343  0.344
2013 Encinas JM, Sierra A, Valcárcel-Martín R, Martín-Suárez S. A developmental perspective on adult hippocampal neurogenesis. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 31: 640-5. PMID 23588197 DOI: 10.1016/J.Ijdevneu.2013.04.001  0.347
2013 Sierra A, Abiega O, Shahraz A, Neumann H. Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. Frontiers in Cellular Neuroscience. 7: 6. PMID 23386811 DOI: 10.3389/fncel.2013.00006  0.327
2012 Encinas JM, Sierra A. Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis. Behavioural Brain Research. 227: 433-9. PMID 22019362 DOI: 10.1016/J.Bbr.2011.10.010  0.358
2011 Tremblay MÈ, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A. The role of microglia in the healthy brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16064-9. PMID 22072657 DOI: 10.1523/Jneurosci.4158-11.2011  0.352
2011 Sierra A, Encinas JM, Maletic-Savatic M. Adult human neurogenesis: from microscopy to magnetic resonance imaging. Frontiers in Neuroscience. 5: 47. PMID 21519376 DOI: 10.3389/Fnins.2011.00047  0.645
2010 Sierra A, Encinas JM, Deudero JJ, Chancey JH, Enikolopov G, Overstreet-Wadiche LS, Tsirka SE, Maletic-Savatic M. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 7: 483-95. PMID 20887954 DOI: 10.1016/J.Stem.2010.08.014  0.656
2010 Gottfried-Blackmore A, Sierra A, McEwen BS, Ge R, Bulloch K. Microglia express functional 11 beta-hydroxysteroid dehydrogenase type 1. Glia. 58: 1257-66. PMID 20544861 DOI: 10.1002/Glia.21007  0.384
2008 Gottfried-Blackmore A, Sierra A, Jellinck PH, McEwen BS, Bulloch K. Brain microglia express steroid-converting enzymes in the mouse. The Journal of Steroid Biochemistry and Molecular Biology. 109: 96-107. PMID 18329265 DOI: 10.1016/J.Jsbmb.2007.12.013  0.486
2008 Sierra A, Gottfried-Blackmore A, Milner TA, McEwen BS, Bulloch K. Steroid hormone receptor expression and function in microglia. Glia. 56: 659-74. PMID 18286612 DOI: 10.1002/Glia.20644  0.412
2007 Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia. 55: 412-24. PMID 17203473 DOI: 10.1002/Glia.20468  0.372
2003 Azcoitia I, Sierra A, Veiga S, Garcia-Segura LM. Aromatase expression by reactive astroglia is neuroprotective. Annals of the New York Academy of Sciences. 1007: 298-305. PMID 14993062  0.723
2003 Garcia-Segura LM, Veiga S, Sierra A, Melcangi RC, Azcoitia I. Aromatase: a neuroprotective enzyme. Progress in Neurobiology. 71: 31-41. PMID 14611865  0.706
2003 Sierra A, Lavaque E, Perez-Martin M, Azcoitia I, Hales DB, Garcia-Segura LM. Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury. The European Journal of Neuroscience. 18: 1458-67. PMID 14511326 DOI: 10.1046/J.1460-9568.2003.02872.X  0.556
2003 Perez-Martin M, Azcoitia I, Trejo JL, Sierra A, Garcia-Segura LM. An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. The European Journal of Neuroscience. 18: 923-30. PMID 12925018  0.446
2003 Sierra A, Azcoitia I, Garcia-Segura L. Endogenous estrogen formation is neuroprotective in model of cerebellar ataxia. Endocrine. 21: 43-51. PMID 12777702  0.541
2001 Azcoitia I, Sierra A, Veiga S, Honda S, Harada N, Garcia-Segura LM. Brain aromatase is neuroprotective. Journal of Neurobiology. 47: 318-29. PMID 11351342 DOI: 10.1002/NEU.1038  0.557
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