Jeffrey Milbrandt, MD, PhD - Publications

Affiliations: 
Genetics Washington University School of Medicine, St. Louis, MO, United States 
Area:
Axonal degeneration, peripheral neuropathy, Myelination, Schwann cell metabolism

197 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Krus KL, Strickland A, Yamada Y, Devault L, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A. Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Cell Reports. 39: 111001. PMID 35767949 DOI: 10.1016/j.celrep.2022.111001  0.543
2022 Weagley JS, Zaydman M, Venkatesh S, Sasaki Y, Damaraju N, Yenkin A, Buchser W, Rodionov DA, Osterman A, Ahmed T, Barratt MJ, DiAntonio A, Milbrandt J, Gordon JI. Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition. Cell Reports. 39: 110738. PMID 35476981 DOI: 10.1016/j.celrep.2022.110738  0.731
2022 Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A. Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. Molecular Neurodegeneration. 17: 1. PMID 34991663 DOI: 10.1186/s13024-021-00511-x  0.592
2022 Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. The Journal of Cell Biology. 221. PMID 34935867 DOI: 10.1083/jcb.202106080  0.638
2021 Ko KW, Devault L, Sasaki Y, Milbrandt J, DiAntonio A. Live imaging reveals the cellular events downstream of SARM1 activation. Elife. 10. PMID 34779400 DOI: 10.7554/eLife.71148  0.631
2021 Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ, DiAntonio A, Milbrandt J. Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss. Cell Reports. 37: 109872. PMID 34686345 DOI: 10.1016/j.celrep.2021.109872  0.637
2021 Eastman S, Smith T, Zaydman MA, Kim P, Martinez S, Damaraju N, DiAntonio A, Milbrandt J, Clemente TE, Alfano JR, Guo M. A phytobacterial TIR domain effector manipulates NAD to promote virulence. The New Phytologist. PMID 34657283 DOI: 10.1111/nph.17805  0.521
2021 DiAntonio A, Milbrandt J, Figley MD. The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems. Frontiers in Immunology. 12: 752898. PMID 34630431 DOI: 10.3389/fimmu.2021.752898  0.578
2021 Sasaki Y, Zhu J, Shi Y, Gu W, Kobe B, Ve T, DiAntonio A, Milbrandt J. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology. 113842. PMID 34403688 DOI: 10.1016/j.expneurol.2021.113842  0.616
2021 Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, ... ... Milbrandt J, et al. SARM1 is a metabolic sensor activated by an increased NMN/NAD ratio to trigger axon degeneration. Neuron. PMID 33657413 DOI: 10.1016/j.neuron.2021.02.009  0.633
2021 Chen YH, Sasaki Y, DiAntonio A, Milbrandt J. SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration. Experimental Neurology. 113636. PMID 33548217 DOI: 10.1016/j.expneurol.2021.113636  0.648
2021 Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Multiple domain interfaces mediate SARM1 autoinhibition. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33468661 DOI: 10.1073/pnas.2023151118  0.58
2021 Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Reports. 34: 108588. PMID 33406435 DOI: 10.1016/j.celrep.2020.108588  0.645
2020 Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N, Dong Z, Lin JB, Boye SL, DiAntonio A, Boye SE, Apte RS, Milbrandt J. SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration. Elife. 9. PMID 33107823 DOI: 10.7554/eLife.62027  0.607
2020 Lalli MA, Langmade SJ, Chen X, Fronick CC, Sawyer CS, Burcea LC, Wilkinson MN, Fulton RS, Heinz M, Buchser WJ, Head RD, Mitra RD, Milbrandt J. Rapid and extraction-free detection of SARS-CoV-2 from saliva by colorimetric reverse-transcription loop-mediated isothermal amplification. Clinical Chemistry. PMID 33098427 DOI: 10.1093/clinchem/hvaa267  0.62
2020 Lalli MA, Avey D, Dougherty JD, Milbrandt J, Mitra RD. High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation. Genome Research. PMID 32887689 DOI: 10.1101/Gr.262295.120  0.317
2020 Ko KW, Milbrandt J, DiAntonio A. SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration. The Journal of Cell Biology. 219. PMID 32609299 DOI: 10.1083/Jcb.201912047  0.682
2020 Bramley JC, Yenkin AL, Zaydman MA, DiAntonio A, Milbrandt JD, Buchser WJ. Domain-centric database to uncover structure of minimally characterized viral genomes. Scientific Data. 7: 202. PMID 32587259 DOI: 10.1038/s41597-020-0536-1  0.709
2020 Lalli MA, Chen X, Langmade SJ, Fronick CC, Sawyer CS, Burcea LC, Fulton RS, Heinz M, Buchser WJ, Head RD, Mitra RD, Milbrandt J. Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP. Medrxiv : the Preprint Server For Health Sciences. PMID 32511508 DOI: 10.1101/2020.05.07.20093542  0.623
2020 Wang PL, Yim AKY, Kim KW, Avey D, Czepielewski RS, Colonna M, Milbrandt J, Randolph GJ. Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia. Nature Communications. 11: 2552. PMID 32439942 DOI: 10.1038/S41467-020-16355-W  0.324
2020 Mikulka CR, Dearborn JT, Benitez BA, Strickland A, Liu L, Milbrandt J, Sands MS. Cell-autonomous expression of the acid hydrolase galactocerebrosidase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32253319 DOI: 10.1073/Pnas.1917675117  0.344
2020 Sasaki Y, Engber TM, Hughes RO, Figley MD, Wu T, Bosanac T, Devraj R, Milbrandt J, Krauss R, DiAntonio A. cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons. Experimental Neurology. 113252. PMID 32087251 DOI: 10.1016/J.Expneurol.2020.113252  0.697
2019 Hackett AR, Strickland A, Milbrandt J. Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy. Glia. PMID 31758725 DOI: 10.1002/Glia.23755  0.408
2019 Summers DW, Frey E, Walker LJ, Milbrandt J, DiAntonio A. DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration. Molecular Neurobiology. PMID 31696428 DOI: 10.1007/S12035-019-01796-2  0.686
2019 Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A. Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. Jci Insight. 4. PMID 31484833 DOI: 10.1172/Jci.Insight.129920  0.683
2019 Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT. TIR domains of plant immune receptors are NAD-cleaving enzymes that promote cell death. Science (New York, N.Y.). 365: 799-803. PMID 31439793 DOI: 10.1126/Science.Aax1771  0.575
2019 Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. The Journal of Experimental Medicine. PMID 30642945 DOI: 10.1084/Jem.20181040  0.692
2018 Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A. HSP90 is a chaperone for DLK and is required for axon injury signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30275300 DOI: 10.1073/Pnas.1805351115  0.662
2018 Avey D, Sankararaman S, Yim AKY, Barve R, Milbrandt J, Mitra RD. Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia. Cell Reports. 24: 3619-3629.e4. PMID 30257220 DOI: 10.1016/J.Celrep.2018.08.080  0.334
2018 Summers DW, Milbrandt J, DiAntonio A. Palmitoylation enables MAPK-dependent proteostasis of axon survival factors. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150401 DOI: 10.1073/Pnas.1806933115  0.687
2018 Kim S, Maynard JC, Strickland A, Burlingame AL, Milbrandt J. Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN. Proceedings of the National Academy of Sciences of the United States of America. PMID 30012597 DOI: 10.1073/Pnas.1805538115  0.653
2018 Sasaki Y, Hackett AR, Kim S, Strickland A, Milbrandt J. Dysregulation of NAD metabolism induces a Schwann cell dedifferentiation program. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29921717 DOI: 10.1523/Jneurosci.3304-17.2018  0.658
2018 Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J. TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes. Current Biology : Cb. PMID 29395922 DOI: 10.1016/J.Cub.2017.12.024  0.612
2017 McGill BE, Barve RA, Maloney SE, Strickland A, Rensing N, Wang P, Wong M, Head R, Wozniak DF, Milbrandt J. Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29133437 DOI: 10.1523/Jneurosci.0936-17.2017  0.36
2017 Beirowski B, Wong KM, Babetto E, Milbrandt J. mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484008 DOI: 10.1073/Pnas.1620761114  0.458
2017 Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J. The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD(+) Cleavage Activity that Promotes Pathological Axonal Degeneration. Neuron. 93: 1334-1343.e5. PMID 28334607 DOI: 10.1016/J.Neuron.2017.02.022  0.691
2017 Walker LJ, Summers DW, Sasaki Y, Brace EJ, Milbrandt J, DiAntonio A. MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2. Elife. 6. PMID 28095293 DOI: 10.7554/Elife.22540  0.682
2016 Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, et al. An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27930300 DOI: 10.1073/Pnas.1610921114  0.32
2016 Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A. Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Brain : a Journal of Neurology. PMID 27797810 DOI: 10.1093/Brain/Aww251  0.691
2016 Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion. Elife. 5. PMID 27735788 DOI: 10.7554/Elife.19749  0.677
2016 Summers DW, Gibson DA, DiAntonio A, Milbrandt J. SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671644 DOI: 10.1073/Pnas.1601506113  0.658
2016 Kim S, Maynard JC, Sasaki Y, Strickland A, Sherman DL, Brophy PJ, Burlingame AL, Milbrandt J. Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9633-9646. PMID 27629714 DOI: 10.1523/Jneurosci.1235-16.2016  0.658
2016 Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM. Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Annals of Clinical and Translational Neurology. 3: 434-42. PMID 27547771 DOI: 10.1002/Acn3.308  0.41
2016 Kurowska Z, Kordower JH, Stoessl AJ, Burke R, Brundin P, Yue Z, Brady ST, Milbrandt J, Trapp BD, Sherer TB, Medicetty S. Is Axonal Degeneration a Key Early Event in Parkinson's Disease? Journal of Parkinson's Disease. PMID 27497486 DOI: 10.3233/Jpd-160881  0.421
2016 Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4681-9. PMID 27122027 DOI: 10.1523/Jneurosci.2893-15.2016  0.702
2016 Gerdts J, Summers DW, Milbrandt J, DiAntonio A. Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism. Neuron. 89: 449-60. PMID 26844829 DOI: 10.1016/J.Neuron.2015.12.023  0.676
2016 Walker LJ, Summers DW, Sasaki Y, Brace E, Milbrandt J, DiAntonio A. Author response: MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2 Elife. DOI: 10.7554/Elife.22540.016  0.667
2016 Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. Author response: NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion Elife. DOI: 10.7554/Elife.19749.024  0.655
2015 Sasaki Y, Margolin Z, Borgo B, Havranek JJ, Milbrandt J. Characterization of Leber's Congenital Amaurosis-associated NMNAT1 Mutants. The Journal of Biological Chemistry. PMID 26018082 DOI: 10.1074/Jbc.M115.637850  0.345
2015 Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J. Neurobiology. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction. Science (New York, N.Y.). 348: 453-7. PMID 25908823 DOI: 10.1126/Science.1258366  0.685
2015 Frey E, Valakh V, Karney-Grobe S, Shi Y, Milbrandt J, DiAntonio A. An in vitro assay to study induction of the regenerative state in sensory neurons. Experimental Neurology. 263: 350-63. PMID 25447942 DOI: 10.1016/J.Expneurol.2014.10.012  0.63
2014 Beirowski B, Babetto E, Golden JP, Chen YJ, Yang K, Gross RW, Patti GJ, Milbrandt J. Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance. Nature Neuroscience. 17: 1351-61. PMID 25195104 DOI: 10.1038/Nn.3809  0.481
2014 Summers DW, DiAntonio A, Milbrandt J. Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9338-50. PMID 25009267 DOI: 10.1523/Jneurosci.0877-14.2014  0.662
2014 Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O'Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, ... ... Milbrandt J, et al. Validation of a next-generation sequencing assay for clinical molecular oncology. The Journal of Molecular Diagnostics : Jmd. 16: 89-105. PMID 24211365 DOI: 10.1016/J.Jmoldx.2013.10.002  0.49
2013 Sharma MK, Phillips J, Agarwal S, Wiggins WS, Shrivastava S, Koul SB, Bhattacharjee M, Houchins CD, Kalakota RR, George B, Meyer RR, Spencer DH, Lockwood CM, Nguyen TT, Duncavage EJ, ... ... Milbrandt JD, et al. Clinical genomicist workstation. Amia Joint Summits On Translational Science Proceedings Amia Summit On Translational Science. 2013: 156-7. PMID 24303327  0.392
2013 Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J. Sarm1-mediated axon degeneration requires both SAM and TIR interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13569-80. PMID 23946415 DOI: 10.1523/Jneurosci.1197-13.2013  0.702
2013 Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A. The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Reports. 3: 1422-9. PMID 23665224 DOI: 10.1016/J.Celrep.2013.04.013  0.684
2013 Viader A, Sasaki Y, Kim S, Strickland A, Workman CS, Yang K, Gross RW, Milbrandt J. Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy. Neuron. 77: 886-98. PMID 23473319 DOI: 10.1016/J.Neuron.2013.01.012  0.81
2013 Chang LW, Viader A, Varghese N, Payton JE, Milbrandt J, Nagarajan R. An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury. Bmc Genomics. 14: 84. PMID 23387820 DOI: 10.1186/1471-2164-14-84  0.784
2013 Zhu Y, Zhang L, Sasaki Y, Milbrandt J, Gidday JM. Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1. Investigative Ophthalmology & Visual Science. 54: 25-36. PMID 23211826 DOI: 10.1167/Iovs.12-10861  0.465
2012 Shin JE, Miller BR, Babetto E, Cho Y, Sasaki Y, Qayum S, Russler EV, Cavalli V, Milbrandt J, DiAntonio A. SCG10 is a JNK target in the axonal degeneration pathway. Proceedings of the National Academy of Sciences of the United States of America. 109: E3696-705. PMID 23188802 DOI: 10.1073/Pnas.1216204109  0.679
2012 Patel A, Harker N, Moreira-Santos L, Ferreira M, Alden K, Timmis J, Foster K, Garefalaki A, Pachnis P, Andrews P, Enomoto H, Milbrandt J, Pachnis V, Coles MC, Kioussis D, et al. Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems. Science Signaling. 5: ra55. PMID 22855506 DOI: 10.1126/Scisignal.2002734  0.342
2012 Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A. Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron. 74: 1015-22. PMID 22726832 DOI: 10.1016/J.Neuron.2012.04.028  0.669
2012 Bhattacharya MR, Gerdts J, Naylor SA, Royse EX, Ebstein SY, Sasaki Y, Milbrandt J, DiAntonio A. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5054-61. PMID 22496551 DOI: 10.1523/Jneurosci.4951-11.2012  0.69
2012 Misko AL, Sasaki Y, Tuck E, Milbrandt J, Baloh RH. Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4145-55. PMID 22442078 DOI: 10.1523/Jneurosci.6338-11.2012  0.68
2011 Viader A, Chang LW, Fahrner T, Nagarajan R, Milbrandt J. MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17358-69. PMID 22131398 DOI: 10.1523/Jneurosci.3931-11.2011  0.786
2011 Viader A, Wright-Jin EC, Vohra BP, Heuckeroth RO, Milbrandt J. Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. Plos One. 6: e27727. PMID 22110743 DOI: 10.1371/Journal.Pone.0027727  0.744
2011 Verghese PB, Sasaki Y, Yang D, Stewart F, Sabar F, Finn MB, Wroge CM, Mennerick S, Neil JJ, Milbrandt J, Holtzman DM. Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death. Proceedings of the National Academy of Sciences of the United States of America. 108: 19054-9. PMID 22058226 DOI: 10.1073/Pnas.1107325108  0.347
2011 Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: E952-61. PMID 21949390 DOI: 10.1073/Pnas.1104969108  0.815
2011 Viader A, Golden JP, Baloh RH, Schmidt RE, Hunter DA, Milbrandt J. Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10128-40. PMID 21752989 DOI: 10.1523/Jneurosci.0884-11.2011  0.815
2011 Gerdts J, Sasaki Y, Vohra B, Marasa J, Milbrandt J. Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration. The Journal of Biological Chemistry. 286: 28011-8. PMID 21685387 DOI: 10.1074/Jbc.M111.250472  0.446
2010 Chang J, Zhang B, Heath H, Galjart N, Wang X, Milbrandt J. Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus. Proceedings of the National Academy of Sciences of the United States of America. 107: 21836-41. PMID 21106760 DOI: 10.1073/Pnas.1002130107  0.402
2010 Sasaki Y, Milbrandt J. Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons. The Journal of Biological Chemistry. 285: 41211-5. PMID 21071441 DOI: 10.1074/Jbc.C110.193904  0.457
2010 Vohra BP, Sasaki Y, Miller BR, Chang J, DiAntonio A, Milbrandt J. Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13729-38. PMID 20943913 DOI: 10.1523/Jneurosci.2939-10.2010  0.685
2010 Sidorova YA, Mätlik K, Paveliev M, Lindahl M, Piranen E, Milbrandt J, Arumäe U, Saarma M, Bespalov MM. Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease. Molecular and Cellular Neurosciences. 44: 223-32. PMID 20350599 DOI: 10.1016/J.Mcn.2010.03.009  0.349
2010 Misko A, Jiang S, Wegorzewska I, Milbrandt J, Baloh RH. Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4232-40. PMID 20335458 DOI: 10.1523/Jneurosci.6248-09.2010  0.651
2010 Golden JP, Hoshi M, Nassar MA, Enomoto H, Wood JN, Milbrandt J, Gereau RW, Johnson EM, Jain S. RET signaling is required for survival and normal function of nonpeptidergic nociceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3983-94. PMID 20237269 DOI: 10.1523/Jneurosci.5930-09.2010  0.333
2010 Jain S, Knoten A, Hoshi M, Wang H, Vohra B, Heuckeroth RO, Milbrandt J. Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. The Journal of Clinical Investigation. 120: 778-90. PMID 20160347 DOI: 10.1172/Jci41619  0.324
2009 Song H, Zhang B, Watson MA, Humphrey PA, Lim H, Milbrandt J. Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene. 28: 3307-19. PMID 19597465 DOI: 10.1038/Onc.2009.181  0.367
2009 Chang J, Baloh RH, Milbrandt J. The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons. Journal of Cell Science. 122: 2274-82. PMID 19509051 DOI: 10.1242/Jcs.048975  0.648
2009 Sasaki Y, Vohra BP, Baloh RH, Milbrandt J. Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6526-34. PMID 19458223 DOI: 10.1523/Jneurosci.1429-09.2009  0.709
2009 Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Shashikant K, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, ... ... Milbrandt J, et al. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. Plos One. 4: e5232. PMID 19412548 DOI: 10.1371/Journal.Pone.0005232  0.393
2009 Sasaki Y, Vohra BP, Lund FE, Milbrandt J. Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5525-35. PMID 19403820 DOI: 10.1523/Jneurosci.5469-08.2009  0.478
2009 Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nature Neuroscience. 12: 387-9. PMID 19287387 DOI: 10.1038/Nn.2290  0.81
2009 Press C, Milbrandt J. The purine nucleosides adenosine and guanosine delay axonal degeneration in vitro. Journal of Neurochemistry. 109: 595-602. PMID 19245660 DOI: 10.1111/J.1471-4159.2009.06002.X  0.774
2009 Baloh RH, Strickland A, Ryu E, Le N, Fahrner T, Yang M, Nagarajan R, Milbrandt J. Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2312-21. PMID 19244508 DOI: 10.1523/Jneurosci.2168-08.2009  0.812
2009 Dasgupta B, Milbrandt J. AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Developmental Cell. 16: 256-70. PMID 19217427 DOI: 10.1016/J.Devcel.2009.01.005  0.334
2008 Ryu EJ, Yang M, Gustin JA, Chang LW, Freimuth RR, Nagarajan R, Milbrandt J. Analysis of peripheral nerve expression profiles identifies a novel myelin glycoprotein, MP11. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7563-73. PMID 18650334 DOI: 10.1523/Jneurosci.1659-08.2008  0.636
2008 Encinas M, Rozen EJ, Dolcet X, Jain S, Comella JX, Milbrandt J, Johnson EM. Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Cell Death and Differentiation. 15: 1510-21. PMID 18497757 DOI: 10.1038/Cdd.2008.76  0.315
2008 Press C, Milbrandt J. Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4861-71. PMID 18463239 DOI: 10.1523/Jneurosci.0525-08.2008  0.777
2008 Brantley MA, Jain S, Barr EE, Johnson EM, Milbrandt J. Neurturin-mediated ret activation is required for retinal function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4123-35. PMID 18417692 DOI: 10.1523/Jneurosci.0249-08.2008  0.379
2007 Ryu EJ, Wang JY, Le N, Baloh RH, Gustin JA, Schmidt RE, Milbrandt J. Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11552-9. PMID 17959798 DOI: 10.1523/Jneurosci.5497-06.2007  0.803
2007 Gustin JA, Yang M, Johnson EM, Milbrandt J. Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth. Journal of Neurochemistry. 102: 1184-94. PMID 17663753 DOI: 10.1111/J.1471-4159.2007.04624.X  0.379
2007 Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development (Cambridge, England). 134: 3191-201. PMID 17652350 DOI: 10.1242/Dev.005884  0.436
2007 Baloh RH, Salavaggione E, Milbrandt J, Pestronk A. Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle. Archives of Neurology. 64: 998-1000. PMID 17620490 DOI: 10.1001/Archneur.64.7.998  0.581
2007 Mullican SE, Zhang S, Konopleva M, Ruvolo V, Andreeff M, Milbrandt J, Conneely OM. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nature Medicine. 13: 730-5. PMID 17515897 DOI: 10.1038/Nm1579  0.365
2007 Uesaka T, Jain S, Yonemura S, Uchiyama Y, Milbrandt J, Enomoto H. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development (Cambridge, England). 134: 2171-81. PMID 17507417 DOI: 10.1242/Dev.001388  0.319
2007 Dasgupta B, Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proceedings of the National Academy of Sciences of the United States of America. 104: 7217-22. PMID 17438283 DOI: 10.1073/Pnas.0610068104  0.307
2007 Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 28: 1653-8. PMID 17434920 DOI: 10.1093/Carcin/Bgm088  0.322
2007 Pierchala BA, Tsui CC, Milbrandt J, Johnson EM. NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation. Journal of Neurochemistry. 100: 1169-76. PMID 17241133 DOI: 10.1111/J.1471-4159.2006.04292.X  0.391
2007 Baloh RH, Schmidt RE, Pestronk A, Milbrandt J. Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 422-30. PMID 17215403 DOI: 10.1523/Jneurosci.4798-06.2007  0.683
2006 Jain S, Golden JP, Wozniak D, Pehek E, Johnson EM, Milbrandt J. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11230-8. PMID 17065462 DOI: 10.1523/Jneurosci.1876-06.2006  0.329
2006 Sasaki Y, Araki T, Milbrandt J. Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8484-91. PMID 16914673 DOI: 10.1523/Jneurosci.2320-06.2006  0.468
2006 Wang X, Baloh RH, Milbrandt J, Garcia KC. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. Structure (London, England : 1993). 14: 1083-92. PMID 16765900 DOI: 10.1016/J.Str.2006.05.010  0.604
2006 Pierchala BA, Milbrandt J, Johnson EM. Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2777-87. PMID 16525057 DOI: 10.1523/Jneurosci.3420-05.2006  0.321
2006 Chang LW, Nagarajan R, Magee JA, Milbrandt J, Stormo GD. A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles. Genome Research. 16: 405-13. PMID 16449500 DOI: 10.1101/Gr.4303406  0.738
2006 Bermingham JR, Shearin H, Pennington J, O'Moore J, Jaegle M, Driegen S, van Zon A, Darbas A, Ozkaynak E, Ryu EJ, Milbrandt J, Meijer D. The claw paw mutation reveals a role for Lgi4 in peripheral nerve development. Nature Neuroscience. 9: 76-84. PMID 16341215 DOI: 10.1038/Nn1598  0.502
2006 Naughton CK, Jain S, Strickland AM, Gupta A, Milbrandt J. Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Biology of Reproduction. 74: 314-21. PMID 16237148 DOI: 10.1095/Biolreprod.105.047365  0.342
2006 Magee JA, Chang LW, Stormo GD, Milbrandt J. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology. 147: 590-8. PMID 16210365 DOI: 10.1210/En.2005-1001  0.689
2006 Baloh R, Milbrandt J, Pestronk A. N.P.3 06 In vitro analysis of MFN2 mutations associated with Charcot-Marie-Tooth disease Neuromuscular Disorders. 16: 666. DOI: 10.1016/J.Nmd.2006.05.082  0.559
2005 Le N, Nagarajan R, Wang JY, Svaren J, LaPash C, Araki T, Schmidt RE, Milbrandt J. Nab proteins are essential for peripheral nervous system myelination. Nature Neuroscience. 8: 932-40. PMID 16136673 DOI: 10.1038/Nn1490  0.771
2005 Kim SJ, Qu Z, Milbrandt J, Zhuo M. A transcription factor for cold sensation! Molecular Pain. 1: 11. PMID 15813958 DOI: 10.1186/1744-8069-1-11  0.309
2005 Le N, Nagarajan R, Wang JY, Araki T, Schmidt RE, Milbrandt J. Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proceedings of the National Academy of Sciences of the United States of America. 102: 2596-601. PMID 15695336 DOI: 10.1073/Pnas.0407836102  0.786
2004 Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM, Milbrandt J. GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron. 44: 623-36. PMID 15541311 DOI: 10.1016/J.Neuron.2004.10.032  0.648
2004 Jain S, Naughton CK, Yang M, Strickland A, Vij K, Encinas M, Golden J, Gupta A, Heuckeroth R, Johnson EM, Milbrandt J. Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development (Cambridge, England). 131: 5503-13. PMID 15469971 DOI: 10.1242/Dev.01421  0.356
2004 Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science (New York, N.Y.). 305: 1010-3. PMID 15310905 DOI: 10.1126/Science.1098014  0.475
2004 Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. The Journal of Biological Chemistry. 279: 42072-81. PMID 15286081 DOI: 10.1074/Jbc.M403726200  0.4
2004 Yan H, Bergner AJ, Enomoto H, Milbrandt J, Newgreen DF, Young HM. Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Developmental Biology. 272: 118-33. PMID 15242795 DOI: 10.1016/J.Ydbio.2004.04.025  0.35
2004 Wanigasekara Y, Airaksinen MS, Heuckeroth RO, Milbrandt J, Keast JR. Neurturin signalling via GFRα2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons Molecular and Cellular Neuroscience. 25: 288-300. PMID 15019945 DOI: 10.1016/J.Mcn.2003.10.019  0.365
2004 Encinas M, Crowder RJ, Milbrandt J, Johnson EM. Tyrosine 981, a novel ret autophosphorylation site, binds c-Src to mediate neuronal survival. The Journal of Biological Chemistry. 279: 18262-9. PMID 14766744 DOI: 10.1074/Jbc.M400505200  0.338
2004 Ethier I, Beaudry G, St-Hilaire M, Milbrandt J, Rouillard C, Lévesque D. The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 335-46. PMID 14603264 DOI: 10.1038/Sj.Npp.1300318  0.305
2003 Golden JP, Milbrandt J, Johnson EM. Neurturin and persephin promote the survival of embryonic basal forebrain cholinergic neurons in vitro. Experimental Neurology. 184: 447-55. PMID 14637114 DOI: 10.1016/J.Expneurol.2003.07.999  0.325
2003 Araki T, Milbrandt J. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9385-94. PMID 14561866 DOI: 10.1523/Jneurosci.23-28-09385.2003  0.305
2003 Magee JA, Abdulkadir SA, Milbrandt J. Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation. Cancer Cell. 3: 273-83. PMID 12676585 DOI: 10.1016/S1535-6108(03)00047-3  0.693
2003 Clements M, Duncan D, Milbrandt J. Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 226: 67-81. PMID 12508226 DOI: 10.1002/Dvdy.10209  0.372
2002 Modur V, Nagarajan R, Evers BM, Milbrandt J. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. The Journal of Biological Chemistry. 277: 47928-37. PMID 12351634 DOI: 10.1074/Jbc.M207509200  0.539
2002 Bettini M, Xi H, Milbrandt J, Kersh GJ. Thymocyte development in early growth response gene 1-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 169: 1713-20. PMID 12165491 DOI: 10.4049/Jimmunol.169.4.1713  0.3
2002 Honma Y, Araki T, Gianino S, Bruce A, Heuckeroth R, Johnson E, Milbrandt J. Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron. 35: 267-82. PMID 12160745 DOI: 10.1016/S0896-6273(02)00774-2  0.419
2002 Tsui-Pierchala BA, Encinas M, Milbrandt J, Johnson EM. Lipid rafts in neuronal signaling and function. Trends in Neurosciences. 25: 412-7. PMID 12127758 DOI: 10.1016/S0166-2236(02)02215-4  0.321
2002 Tsui-Pierchala BA, Ahrens RC, Crowder RJ, Milbrandt J, Johnson EM. The long and short isoforms of Ret function as independent signaling complexes. The Journal of Biological Chemistry. 277: 34618-25. PMID 12091387 DOI: 10.1074/Jbc.M203580200  0.33
2002 Nagarajan R, Le N, Mahoney H, Araki T, Milbrandt J. Deciphering peripheral nerve myelination by using Schwann cell expression profiling. Proceedings of the National Academy of Sciences of the United States of America. 99: 8998-9003. PMID 12084938 DOI: 10.1073/Pnas.132080999  0.768
2002 Rakowicz WP, Staples CS, Milbrandt J, Brunstrom JE, Johnson EM. Glial cell line-derived neurotrophic factor promotes the survival of early postnatal spinal motor neurons in the lateral and medial motor columns in slice culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3953-62. PMID 12019314 DOI: 10.1523/Jneurosci.22-10-03953.2002  0.33
2002 Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Molecular and Cellular Biology. 22: 1495-503. PMID 11839815 DOI: 10.1128/Mcb.22.5.1495-1503.2002  0.676
2002 Tsui-Pierchala BA, Milbrandt J, Johnson EM. NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons. Neuron. 33: 261-73. PMID 11804573 DOI: 10.1016/S0896-6273(01)00585-2  0.323
2002 Tourtellotte WG, Keller-Peck C, Milbrandt J, Kucera J. Erratum: The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis (Developmental Biology (2001) 232 (2) (388-399) PII: S0012160601902027) Developmental Biology. 252. DOI: 10.1006/Dbio.2002.0908  0.387
2001 Araki T, Nagarajan R, Milbrandt J. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. The Journal of Biological Chemistry. 276: 34131-41. PMID 11427537 DOI: 10.1074/Jbc.M104271200  0.598
2001 Tourtellotte WG, Keller-Peck C, Milbrandt J, Kucera J. The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis. Developmental Biology. 232: 388-99. PMID 11401400 DOI: 10.1006/Dbio.2001.0202  0.382
2001 Nagarajan R, Svaren J, Le N, Araki T, Watson M, Milbrandt J. EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression. Neuron. 30: 355-68. PMID 11394999 DOI: 10.1016/S0896-6273(01)00282-3  0.771
2001 Houston P, Campbell CJ, Svaren J, Milbrandt J, Braddock M. The transcriptional corepressor NAB2 blocks Egr-1-mediated growth factor activation and angiogenesis. Biochemical and Biophysical Research Communications. 283: 480-6. PMID 11327726 DOI: 10.1006/Bbrc.2001.4810  0.316
2001 Dzialo-Hatton R, Milbrandt J, Hockett J, Weaver CT. Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members Journal of Immunology. 166: 4534-4542. PMID 11254710 DOI: 10.4049/Jimmunol.166.7.4534  0.313
2001 Encinas M, Tansey MG, Tsui-Pierchala BA, Comella JX, Milbrandt J, Johnson EM. c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1464-72. PMID 11222636 DOI: 10.1523/Jneurosci.21-05-01464.2001  0.332
2001 Magee J, Patil S, Milbrandt J. Expression profiling of androgen target genes in prostate cancer Nature Genetics. 27: 71-71. DOI: 10.1038/87196  0.664
2000 Svaren J, Ehrig T, Abdulkadir SA, Ehrengruber MU, Watson MA, Milbrandt J. EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis Journal of Biological Chemistry. 275: 38524-38531. PMID 10984481 DOI: 10.1074/Jbc.M005220200  0.317
2000 Tourtellotte WG, Nagarajan R, Bartke A, Milbrandt J. Functional compensation by Egr4 in Egr1-dependent luteinizing hormone regulation and Leydig cell steroidogenesis. Molecular and Cellular Biology. 20: 5261-8. PMID 10866682 DOI: 10.1128/Mcb.20.14.5261-5268.2000  0.536
2000 Tansey MG, Baloh RH, Milbrandt J, Johnson EM. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron. 25: 611-23. PMID 10774729 DOI: 10.1016/S0896-6273(00)81064-8  0.597
2000 Sevetson BR, Svaren J, Milbrandt J. A Novel Activation Function for NAB Proteins in EGR-dependent Transcription of the Luteinizing Hormone β Gene Journal of Biological Chemistry. 275: 9749-9757. PMID 10734128 DOI: 10.1074/Jbc.275.13.9749  0.332
2000 Ho TW, Bristol LA, Coccia C, Li Y, Milbrandt J, Johnson E, Jin L, Bar-Peled O, Griffin JW, Rothstein JD. TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity. Experimental Neurology. 161: 664-75. PMID 10686085 DOI: 10.1006/Exnr.1999.7290  0.435
2000 Baloh RH, Enomoto H, Johnson EM, Milbrandt J. The GDNF family ligands and receptors - implications for neural development. Current Opinion in Neurobiology. 10: 103-10. PMID 10679429 DOI: 10.1016/S0959-4388(99)00048-3  0.623
2000 Baloh RH, Tansey MG, Johnson EM, Milbrandt J. Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists. The Journal of Biological Chemistry. 275: 3412-20. PMID 10652334 DOI: 10.1074/Jbc.275.5.3412  0.618
2000 Araki T, Milbrandt J. Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory and enteric neurons and promotes neurite outgrowth. The Journal of Neuroscience. 20: 187-195. DOI: 10.1523/Jneurosci.20-01-00187.2000  0.401
1999 Leitner ML, Molliver DC, Osborne PA, Vejsada R, Golden JP, Lampe PA, Kato AC, Milbrandt J, Johnson EM. Analysis of the retrograde transport of glial cell line-derived neurotrophic factor (GDNF), neurturin, and persephin suggests that in vivo signaling for the GDNF family is GFRalpha coreceptor-specific. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9322-31. PMID 10531437 DOI: 10.1523/Jneurosci.19-21-09322.1999  0.318
1999 Hashino E, Johnson EM, Milbrandt J, Shero M, Salvi RJ, Cohan CS. Multiple actions of neurturin correlate with spatiotemporal patterns of Ret expression in developing chick cranial ganglion neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8476-86. PMID 10493748 DOI: 10.1523/Jneurosci.19-19-08476.1999  0.31
1999 Golden JP, DeMaro JA, Osborne PA, Milbrandt J, Johnson EM. Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Experimental Neurology. 158: 504-28. PMID 10415156 DOI: 10.1006/Exnr.1999.7127  0.333
1999 Warner LE, Svaren J, Milbrandt J, Lupski JR. Functional Consequences of Mutations in the Early Growth Response 2 Gene (EGR2) Correlate with Severity of Human Myelinopathies Human Molecular Genetics. 8: 1245-1251. PMID 10369870 DOI: 10.1093/Hmg/8.7.1245  0.331
1999 Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM, Milbrandt J. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 22: 253-63. PMID 10069332 DOI: 10.1016/S0896-6273(00)81087-9  0.339
1999 Naughton CK, Tourtellotte WG, Smith DS, Milbrandt J. Prostate Apoptosis in Response to Castration in Wild‐Type and Nerve Growth Factor‐Induced Gene A‐Deficient Mice The Prostate Journal. 1: 88-92. DOI: 10.1046/J.1525-1411.1999.09911.X  0.312
1998 Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron. 21: 1291-302. PMID 9883723 DOI: 10.1016/S0896-6273(00)80649-2  0.616
1998 Srivastava S, Weitzmann MN, Kimble RB, Rizzo M, Zahner M, Milbrandt J, Ross FP, Pacifici R. Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1. Journal of Clinical Investigation. 102: 1850-1859. PMID 9819371 DOI: 10.1172/Jci4561  0.306
1998 Svaren J, Sevetson BR, Golda T, Stanton JJ, Swirnoff AH, Milbrandt J. Novel mutants of NAB corepressors enhance activation by Egr transactivators The Embo Journal. 17: 6010-6019. PMID 9774344 DOI: 10.1093/Emboj/17.20.6010  0.313
1998 Tourtellotte WG, Milbrandt J. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nature Genetics. 20: 87-91. PMID 9731539 DOI: 10.1038/1757  0.345
1998 Qu Z, Wolfraim LA, Svaren J, Ehrengruber MU, Davidson N, Milbrandt J. The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells Journal of Cell Biology. 142: 1075-1082. PMID 9722618 DOI: 10.1083/Jcb.142.4.1075  0.307
1998 Golden JP, Baloh RH, Kotzbauer PT, Lampe PA, Osborne PA, Milbrandt J, Johnson EM. Expression of neurturin, GDNF, and their receptors in the adult mouse CNS. The Journal of Comparative Neurology. 398: 139-50. PMID 9703032 DOI: 10.1002/(Sici)1096-9861(19980817)398:1<139::Aid-Cne9>3.0.Co;2-2  0.623
1998 Heuckeroth RO, Lampe PA, Johnson EM, Milbrandt J. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Developmental Biology. 200: 116-29. PMID 9698461 DOI: 10.1006/Dbio.1998.8955  0.333
1998 Yan SF, Zou YS, Gao Y, Zhai C, Mackman N, Lee SL, Milbrandt J, Pinsky D, Kisiel W, Stern D. Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia Proceedings of the National Academy of Sciences of the United States of America. 95: 8298-8303. PMID 9653181 DOI: 10.1073/Pnas.95.14.8298  0.309
1998 Horger BA, Nishimura MC, Armanini MP, Wang LC, Poulsen KT, Rosenblad C, Kirik D, Moffat B, Simmons L, Johnson E, Milbrandt J, Rosenthal A, Bjorklund A, Vandlen RA, Hynes MA, et al. Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 4929-37. PMID 9634558 DOI: 10.1523/Jneurosci.18-13-04929.1998  0.311
1998 Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J. GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proceedings of the National Academy of Sciences of the United States of America. 95: 5801-6. PMID 9576965 DOI: 10.1073/Pnas.95.10.5801  0.617
1998 Crawford PA, Dorn C, Sadovsky Y, Milbrandt J. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1. Molecular and Cellular Biology. 18: 2949-56. PMID 9566914 DOI: 10.1128/Mcb.18.5.2949  0.314
1998 Zaiou M, Azrolan N, Hayek T, Wang H, Wu L, Haghpassand M, Cizman B, Madaio MP, Milbrandt J, Marsh JB, Breslow JL, Fisher EA. The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1. The Journal of Clinical Investigation. 101: 1699-707. PMID 9541501 DOI: 10.1172/Jci2166  0.312
1998 Milbrandt J, de Sauvage FJ, Fahrner TJ, Baloh RH, Leitner ML, Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS, Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, et al. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron. 20: 245-53. PMID 9491986 DOI: 10.1016/S0896-6273(00)80453-5  0.638
1998 Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J. Nab1, a Corepressor of NGFI-A (Egr-1), Contains an Active Transcriptional Repression Domain Molecular and Cellular Biology. 18: 512-524. PMID 9418898 DOI: 10.1128/Mcb.18.1.512  0.371
1997 Katagiri Y, Hirata Y, Milbrandt J, Guroff G. Differential Regulation of the Transcriptional Activity of the Orphan Nuclear Receptor NGFI-B by Membrane Depolarization and Nerve Growth Factor Journal of Biological Chemistry. 272: 31278-31284. PMID 9395454 DOI: 10.1074/Jbc.272.50.31278  0.336
1997 Heuckeroth RO, Kotzbauer P, Copeland NG, Gilbert DJ, Jenkins NA, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Genomics. 44: 137-40. PMID 9286710 DOI: 10.1006/Geno.1997.4846  0.308
1997 Araki T, Zimonjic DB, Popescu NC, Milbrandt J. Mechanism of Homophilic Binding Mediated by Ninjurin, a Novel Widely Expressed Adhesion Molecule Journal of Biological Chemistry. 272: 21373-21380. PMID 9261151 DOI: 10.1074/Jbc.272.34.21373  0.381
1997 Crawford PA, Sadovsky Y, Milbrandt J. Nuclear receptor steroidogenic factor 1 directs embryonic stem cells toward the steroidogenic lineage. Molecular and Cellular Biology. 17: 3997-4006. PMID 9199334 DOI: 10.1128/Mcb.17.7.3997  0.368
1997 Creedon DJ, Tansey MG, Baloh RH, Osborne PA, Lampe PA, Fahrner TJ, Heuckeroth RO, Milbrandt J, Johnson EM. Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 94: 7018-23. PMID 9192684 DOI: 10.1073/Pnas.94.13.7018  0.625
1997 Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. 18: 793-802. PMID 9182803 DOI: 10.1016/S0896-6273(00)80318-9  0.622
1997 Woodson KG, Crawford PA, Sadovsky Y, Milbrandt J. Characterization of the promoter of SF-1, an orphan nuclear receptor required for adrenal and gonadal development. Molecular Endocrinology (Baltimore, Md.). 11: 117-26. PMID 9013759 DOI: 10.1210/Mend.11.2.9881  0.327
1996 Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM, Milbrandt J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor Nature. 384: 467-470. PMID 8945474 DOI: 10.1038/384467A0  0.338
1996 Araki T, Milbrandt J. Ninjurin, a Novel Adhesion Molecule, Is Induced by Nerve Injury and Promotes Axonal Growth Neuron. 17: 353-361. PMID 8780658 DOI: 10.1016/S0896-6273(00)80166-X  0.443
1996 Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Molecular and Cellular Biology. 16: 3545-3553. PMID 8668170 DOI: 10.1128/Mcb.16.7.3545  0.361
1995 Lee SL, Tourtellotte LC, Wesselschmidt RL, Milbrandt J. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. The Journal of Biological Chemistry. 270: 9971-7. PMID 7730380 DOI: 10.1074/Jbc.270.17.9971  0.341
1995 Russo MW, Sevetson BR, Milbrandt J. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription Proceedings of the National Academy of Sciences of the United States of America. 92: 6873-6877. PMID 7624335 DOI: 10.1073/Pnas.92.15.6873  0.376
1995 Sadovsky Y, Crawford PA, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J. Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proceedings of the National Academy of Sciences of the United States of America. 92: 10939-43. PMID 7479914 DOI: 10.1073/Pnas.92.24.10939  0.34
1995 Carroll S, Schweitzer J, Holtzman D, Miller M, Sclar G, Milbrandt J. Elements in the 5' flanking sequences of the mouse low-affinity NGF receptor gene direct appropriate CNS, but not PNS, expression in transgenic mice The Journal of Neuroscience. 15: 3342-3356. DOI: 10.1523/Jneurosci.15-05-03342.1995  0.379
1994 Kotzbauer PT, Lampe PA, Estus S, Milbrandt J, Johnson EM. Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor Neuron. 12: 763-773. PMID 8161448 DOI: 10.1016/0896-6273(94)90329-8  0.316
1993 Wanaka A, Carroll SL, Milbrandt J. Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat. Brain Research. Developmental Brain Research. 72: 133-44. PMID 8453763 DOI: 10.1016/0165-3806(93)90166-8  0.344
1993 Russo MW, Matheny C, Milbrandt J. Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor. Molecular and Cellular Biology. 13: 6858-6865. PMID 8413279 DOI: 10.1128/Mcb.13.11.6858  0.312
1993 Wilson TE, Mouw AR, Weaver CA, Milbrandt J, Parker KL. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Molecular and Cellular Biology. 13: 861-8. PMID 8380897 DOI: 10.1128/mcb.13.2.861-868.1993  0.302
1992 Crosby SD, Veile RA, Donis-Keller H, Baraban JM, Bhat RV, Simburger KS, Milbrandt J. Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C. Proceedings of the National Academy of Sciences of the United States of America. 89: 4739-43. PMID 1584812 DOI: 10.1073/Pnas.89.10.4739  0.307
1992 Carroll SL, Silos-Santiago I, Frese SE, Ruit KG, Milbrandt J, Snider WD. Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero. Neuron. 9: 779-88. PMID 1389185 DOI: 10.1016/0896-6273(92)90040-K  0.33
1992 Matheny C, DiStefano PS, Milbrandt J. Differential activation of NGF receptor and early response genes in neural crest-derived cells. Brain Research. Molecular Brain Research. 13: 75-81. PMID 1315920 DOI: 10.1016/0169-328X(92)90046-E  0.363
1991 Crosby SD, Puetz JJ, Simburger KS, Fahrner TJ, Milbrandt J. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. Molecular and Cellular Biology. 11: 3835-3841. PMID 2072895 DOI: 10.1128/Mcb.11.8.3835  0.314
1990 Li YS, Milner PG, Chauhan AK, Watson MA, Hoffman RM, Kodner CM, Milbrandt J, Deuel TF. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science (New York, N.Y.). 250: 1690-4. PMID 2270483 DOI: 10.1126/Science.2270483  0.328
1989 Changelian PS, Feng P, King TC, Milbrandt J. Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor. Proceedings of the National Academy of Sciences of the United States of America. 86: 377-81. PMID 2492104 DOI: 10.1073/Pnas.86.1.377  0.324
1989 Watson MA, Milbrandt J. The NGFI-B gene, a transcriptionally inducible member of the steroid receptor gene superfamily: Genomic structure and expression in rat brain after seizure induction Molecular and Cellular Biology. 9: 4213-4219. PMID 2479823 DOI: 10.1128/Mcb.9.10.4213  0.324
1988 Milbrandt J. Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene Neuron. 1: 183-188. PMID 3272167 DOI: 10.1016/0896-6273(88)90138-9  0.363
1987 Milbrandt J. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor Science. 238: 797-799. PMID 3672127 DOI: 10.1126/Science.3672127  0.35
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