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Jane A. Little, M.D. - Publications

Affiliations: 
1990-2000 University of Minnesota, Twin Cities, Minneapolis, MN 
 2001-2006 National Institutes of Health, Bethesda, MD 
 2006-2011 Albert Einstein College of Medicine, New York, New York, United States 
 2011-2018 Case Western Reserve University, Cleveland Heights, OH, United States 
 2018- University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
hematology
Website:
https://www.med.unc.edu/medicine/directory/jane-little/
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Johnson S, Gordeuk VR, Machado R, Gibbs JSR, Hildesheim M, Little JA, Kato GJ, Gladwin MT, Nouraie M. Exercise Induced Changes of Vital Signs in Adults with Sickle Cell Disease. American Journal of Hematology. PMID 34626431 DOI: 10.1002/ajh.26369  0.452
2020 Kucukal E, Man Y, Quinn E, Tewari N, An R, Ilich A, Key NS, Little JA, Gurkan UA. Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease. Blood Advances. 4: 3688-3698. PMID 32777069 DOI: 10.1182/Bloodadvances.2020001656  0.334
2020 Nouraie M, Ashley-Koch AE, Garrett ME, Sritharan N, Zhang Y, Little J, Gordeuk VR, Gladwin MT, Telen MJ, Kato GJ. Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts. Plos One. 15: e0237543. PMID 32776978 DOI: 10.1371/Journal.Pone.0237543  0.485
2020 Kucukal E, Man Y, Hill A, Liu S, Bode A, An R, Kadambi J, Little JA, Gurkan UA. Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease. American Journal of Hematology. PMID 32656816 DOI: 10.1002/Ajh.25933  0.341
2020 Man Y, Kucukal E, An R, Watson QD, Bosch J, Zimmerman PA, Little JA, Gurkan UA. Microfluidic assessment of red blood cell mediated microvascular occlusion. Lab On a Chip. PMID 32427268 DOI: 10.1039/D0Lc00112K  0.351
2020 Man Y, Goreke U, Kucukal E, Hill A, An R, Liu S, Bode A, Solis-Fuentes A, Nayak LV, Little JA, Gurkan UA. Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: A standardized microfluidic assessment. Blood Cells, Molecules & Diseases. 83: 102424. PMID 32208292 DOI: 10.1016/J.Bcmd.2020.102424  0.333
2019 Farrell AT, Panepinto J, Desai AA, Kassim AA, Lebensburger J, Walters MC, Bauer DE, Blaylark RM, DiMichele DM, Gladwin MT, Green NS, Hassell K, Kato GJ, Klings ES, Kohn DB, ... ... Little J, et al. End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings. Blood Advances. 3: 4002-4020. PMID 31809537 DOI: 10.1182/Bloodadvances.2019000883  0.462
2019 Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT. Validation of a composite vascular high risk profile for adult patients with sickle cell disease. American Journal of Hematology. PMID 31444803 DOI: 10.1002/Ajh.25624  0.484
2019 Carden MA, Little J. Emerging non-genetic therapies for sickle cell disease. Haematologica. PMID 31413089 DOI: 10.3324/Haematol.2018.207357  0.407
2019 Sinha AA, Adusumilli T, Cohen HW, Nouraie M, Little J, Manwani D. Splenectomy is not associated with a higher tricuspid regurgitant jet velocity in people with sickle cell anemia. Pediatric Blood & Cancer. e27928. PMID 31322833 DOI: 10.1002/Pbc.27928  0.358
2019 Gollamudi J, Sarvepalli S, Alin T, Vadaparti A, Little JA, Nayak LV. Venous Thromboembolism (VTE) in Sickle Cell Disease (SCD) Is Associated with Neutrophilia Blood. 134: 791-791. DOI: 10.1182/Blood-2019-128855  0.355
2019 McLean A, Young L, Boynton MH, Wilson S, Little JA, Carden MA. Prevalence and Monitoring of Diabetes Among Adults with Sickle Cell Disease: A Single Institution Experience Blood. 134: 4832-4832. DOI: 10.1182/Blood-2019-128843  0.363
2019 Saraf SL, Derebail VK, Zhang X, Gladwin MT, Gordeuk VR, Little JA. Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia Blood. 134: 2268-2268. DOI: 10.1182/Blood-2019-124737  0.438
2016 Drawz P, Ayyappan S, Nouraie M, Saraf S, Gordeuk V, Hostetter T, Gladwin MT, Little J. Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC. Clinical Journal of the American Society of Nephrology : Cjasn. 11: 207-15. PMID 26672090 DOI: 10.2215/Cjn.03940415  0.408
2015 Karkashon S, Raghupathy R, Bhatia H, Dutta A, Hess S, Higgs J, Tifft CJ, Little JA. Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells. Blood Cells, Molecules & Diseases. 55: 161-7. PMID 26142333 DOI: 10.1016/J.Bcmd.2015.05.006  0.344
2015 Rotz SJ, O'Riordan MA, Kim C, de Lima M, Gladwin MT, Little JA. Traffic Light: prognosis-based eligibility for clinical trials of hematopoietic SCT in adults with sickle cell anemia. Bone Marrow Transplantation. 50: 918-23. PMID 25774596 DOI: 10.1038/Bmt.2015.11  0.441
2014 Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, et al. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. Plos One. 9: e99489. PMID 24988120 DOI: 10.1371/Journal.Pone.0099489  0.422
2014 Saraf SL, Zhang X, Kanias T, Lash JP, Molokie RE, Oza B, Lai C, Rowe JH, Gowhari M, Hassan J, Desimone J, Machado RF, Gladwin MT, Little JA, Gordeuk VR. Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia. British Journal of Haematology. 164: 729-39. PMID 24329963 DOI: 10.1111/Bjh.12690  0.441
2013 Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, ... Little JA, et al. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica. 98: 464-72. PMID 22983573 DOI: 10.3324/Haematol.2012.068965  0.44
2012 Ayyappan S, Drawz P, Nouraie M, Hildesheim ME, Zhang Y, Gordeuk VR, Hostetter TH, Gladwin MT, Little JA. Renal Disease in Sickle Cell: Clinically Varied and Associated with Increased Mortality Blood. 120: 90-90. DOI: 10.1182/Blood.V120.21.90.90  0.451
2011 Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, et al. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 124: 1452-60. PMID 21900080 DOI: 10.1161/Circulationaha.111.032920  0.461
2011 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, et al. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood. 118: 855-64. PMID 21527519 DOI: 10.1182/Blood-2010-09-306167  0.493
2011 McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo. Blood. 117: 4600-8. PMID 21378272 DOI: 10.1182/Blood-2010-12-325357  0.363
2011 Lorch D, Spevack D, Little J. An elevated estimated pulmonary arterial systolic pressure, whenever measured, is associated with excess mortality in adults with sickle cell disease. Acta Haematologica. 125: 225-9. PMID 21282944 DOI: 10.1159/000323464  0.327
2011 Dutta A, Karkashon S, Raghupathy R, Bhatia H, Tesfa L, Little JA. Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells. Blood Cells, Molecules & Diseases. 46: 125-32. PMID 21094617 DOI: 10.1016/J.Bcmd.2010.10.013  0.425
2011 Goel R, Hassell KL, Machado RF, Barst RJ, Yovetich N, Kato GJ, Gordeuk VR, Little JA, Gibbs JSR, Schraufnagel DE, Girgis RE, Rosenzweig EB, Morris CR, Badesch DB, Lanzkron S, et al. Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study Blood. 118: 1074-1074. DOI: 10.1182/Blood.V118.21.1074.1074  0.494
2010 Raghupathy R, Manwani D, Little JA. Iron overload in sickle cell disease. Advances in Hematology. 2010: 272940. PMID 20490352 DOI: 10.1155/2010/272940  0.348
2010 Barst RJ, Kato GJ, Sachdev V, Nouraie M, Machado RF, Hassell K, Gibbs S, Little J, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Castro O, et al. Predictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study Blood. 116: 947-947. DOI: 10.1182/Blood.V116.21.947.947  0.527
2010 Goel R, Hassell K, Castro O, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Gibbs S, Little JA, Schraufnagel DE, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Goldsmith JC, et al. Cigarette Smoking Is An Independent Predictor of Chronic Pain In Sickle Cell Patients: Results From the Walk-PHaSST Study Blood. 116: 4804-4804. DOI: 10.1182/Blood.V116.21.4804.4804  0.435
2010 Krishnamurti L, Goel R, Castro O, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Gibbs S, Little JA, Schraufnagel DE, Girgis RE, Morris CR, Badesch DB, Lanzkron S, Goldsmith JC, et al. Chronic Pain Is An Independent Predictor of Lower 6 Minute Walk Distance In Patients with Sickle Cell Disease: Results From Walk-PHaSST Study Blood. 116: 2658-2658. DOI: 10.1182/Blood.V116.21.2658.2658  0.442
2010 Raghupathy R, Karkashon S, Fazzari MJ, Little JA. Butyrate Downregulates the Expression of a Number of Repressors of Fetal Hemoglobin In Definitive Erythroid Cells Blood. 116: 2080-2080. DOI: 10.1182/Blood.V116.21.2080.2080  0.445
2010 Nouraie M, Barst RJ, Rosenzweig EB, Sachdev V, Machado RF, Hassell K, Gibbs JSR, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Badesch DB, Lanzkron S, et al. NT-Probnp as a Marker of Cardiopulmonary Compromise and Exercise Limitation In Adults with Sickle Cell Anemia In the Walk-PHaSST Study Blood. 116: 1639-1639. DOI: 10.1182/Blood.V116.21.1639.1639  0.52
2009 Bhatia H, Hallock JL, Dutta A, Karkashon S, Sterner LS, Miyazaki T, Dean A, Little JA. Short-chain fatty acid-mediated effects on erythropoiesis in primary definitive erythroid cells. Blood. 113: 6440-8. PMID 19380871 DOI: 10.1182/Blood-2008-09-171728  0.666
2009 Little JA, Hauser KP, Martyr SE, Harris A, Maric I, Morris CR, Suh JH, Taylor J, Castro O, Machado R, Kato G, Gladwin MT. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. European Journal of Haematology. 82: 315-21. PMID 19215288 DOI: 10.1111/J.1600-0609.2009.01210.X  0.491
2009 Machado RF, Barst RJ, Yovetich NA, Hassell KL, Goldsmith JC, Woolson R, Gordeuk VR, Gibbs S, Little JA, Kato GJ, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Berman-Rosenzweig E, et al. Safety and Efficacy of Sildenafil Therapy for Doppler-Defined Pulmonary Hypertension in Patients with Sickle Cell Disease: Preliminary Results of the Walk-PHaSST Clinical Trial. Blood. 114: 571-571. DOI: 10.1182/Blood.V114.22.571.571  0.49
2009 Dutta A, Bhatia H, Karkashon S, Tesfa L, Little J. Short Chain Fatty Acids and p38 in the Induction of Embryonic/Fetal Globin Genes During Definitive Erythropoiesis. Blood. 114: 460-460. DOI: 10.1182/Blood.V114.22.460.460  0.409
2009 McGrath KE, Frame JM, Fromm G, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. “Definitive” Erythropoiesis Has Distinct Developmental Origins and Globin Expression Patterns in the Mammalian Embryo. Blood. 114: 2539-2539. DOI: 10.1182/Blood.V114.22.2539.2539  0.385
2009 Lorch D, Spevack D, Little J. Chronic Kidney Disease and Mild Elevations in Pulmonary Arterial Systolic Pressure Are Associated with Increased Mortality in Adult Patients with Sickle Cell Disease. Blood. 114: 1539-1539. DOI: 10.1182/Blood.V114.22.1539.1539  0.38
2008 Kiefer CM, Hou C, Little JA, Dean A. Epigenetics of beta-globin gene regulation. Mutation Research. 647: 68-76. PMID 18760288 DOI: 10.1016/J.Mrfmmm.2008.07.014  0.641
2008 Bhatia H, Hallock JL, Sterner LE, Karkashon S, Dutta A, Miyazaki T, Dean A, Little J. A Novel Model of Short Chain Fatty Acid (SCFA)- Mediated up-Regulation of Embryonic/Fetal Globin Genes during Definitive Erythropoiesis. Blood. 112: 1878-1878. DOI: 10.1182/Blood.V112.11.1878.1878  0.655
2007 Bhatia H, Higgs J, Hess S, Tifft C, Little J. Intermediaries of Branched-Chain Amino Acid Metabolism Can Increase Fetal Hemoglobin In Vitro and In Vivo. Blood. 110: 3834-3834. DOI: 10.1182/Blood.V110.11.3834.3834  0.398
2007 Little JA, Hauser KP, Martyr SE, Kato GJ, Machado R, Castro O, Taylor J, Gladwin MT. Phosphodiesterase Inhibition Increases Fetal Hemoglobin in Sickle Cell Disease; L-Arginine Supplementation Does Not. Blood. 110: 3396-3396. DOI: 10.1182/Blood.V110.11.3396.3396  0.496
2007 Bhatia H, Hallock J, Sterner L, Miyazaki T, Dean A, Little J. Endogenous Elevations of Short Chain Fatty Acids (SCFAs) Can Up-Regulate Embryonic Globin Gene Expression. Blood. 110: 1770-1770. DOI: 10.1182/Blood.V110.11.1770.1770  0.639
2006 Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor JG, Machado RF, Heller T, Castro O, Gladwin MT. Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 91: 1076-83. PMID 16885048 DOI: 10.3324/%%X  0.517
2006 Kato GJ, Hsieh M, Machado R, Taylor J, Little J, Butman JA, Lehky T, Tisdale J, Gladwin MT. Cerebrovascular disease associated with sickle cell pulmonary hypertension. American Journal of Hematology. 81: 503-10. PMID 16755569 DOI: 10.1002/Ajh.20642  0.494
2006 Kato GJ, McGowan V, Machado RF, Little JA, Taylor J, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris SM, Gladwin MT. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 107: 2279-85. PMID 16291595 DOI: 10.1182/Blood-2005-06-2373  0.444
2005 Hallock JL, Sterner LJ, Little JA. Enhanced Erythroid Differentiation of Murine Embryoid Bodies That Are Exposed to Short-Chain Fatty Acids during Development. Blood. 106: 3646-3646. DOI: 10.1182/Blood.V106.11.3646.3646  0.427
2005 Partovi K, Martyr S, McGowan V, Machado R, Taylor J, Kato G, Gladwin M, Little J. Early Predictors of Fetal Hemoglobin Response to Hydroxyurea in Sickle Cell Disease. Blood. 106: 2344-2344. DOI: 10.1182/Blood.V106.11.2344.2344  0.501
2004 Sterner L, Miyazaki T, Swift L, Dean A, Little J. Endogenous Elevations of Short Chain Fatty Acids Up-Regulate Embryonic Globin Gene Expression during Primitive Erythropoiesis. Blood. 104: 1210-1210. DOI: 10.1182/Blood.V104.11.1210.1210  0.636
1998 Ginder GD, Singal R, Little JA, Dempsey N, Ferris R, Wang SZ. Silencing and activation of embryonic globin gene expression. Annals of the New York Academy of Sciences. 850: 70-9. PMID 9668529 DOI: 10.1111/J.1749-6632.1998.Tb10464.X  0.646
1997 Singal R, Ferris R, Little JA, Wang SZ, Ginder GD. Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 13724-9. PMID 9391093 DOI: 10.1073/Pnas.94.25.13724  0.612
1995 Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF. Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. The New England Journal of Medicine. 332: 1606-10. PMID 7753139 DOI: 10.1056/Nejm199506153322404  0.615
1995 Little JA, Dempsey NJ, Tuchman M, Ginder GD. Metabolic persistence of fetal hemoglobin. Blood. 85: 1712-8. PMID 7535584 DOI: 10.1182/Blood.V85.7.1712.Bloodjournal8571712  0.625
1991 Glauber JG, Wandersee NJ, Little JA, Ginder GD. 5'-flanking sequences mediate butyrate stimulation of embryonic globin gene expression in adult erythroid cells. Molecular and Cellular Biology. 11: 4690-7. PMID 1875947 DOI: 10.1128/mcb.11.9.4690  0.65
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