David L Vaux - Publications

Affiliations: 
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 
Area:
cell death

154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Strasser A, Vaux DL. Cell Death in the Origin and Treatment of Cancer. Molecular Cell. PMID 32516599 DOI: 10.1016/J.Molcel.2020.05.014  0.446
2020 Dong L, Vaux DL. Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1. Cell Death & Disease. 11: 442. PMID 32513923 DOI: 10.1038/S41419-020-2599-5  0.524
2020 Lalaoui N, Merino D, Giner G, Vaillant F, Chau D, Liu L, Kratina T, Pal B, Whittle JR, Etemadi N, Berthelet J, Gräsel J, Hall C, Ritchie ME, Ernst M, ... ... Vaux DL, et al. Targeting triple-negative breast cancers with the Smac-mimetic birinapant. Cell Death and Differentiation. PMID 32341449 DOI: 10.1038/S41418-020-0541-0  0.362
2019 Gray DHD, Vaux DL, Strasser A. The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system. Cell Death and Differentiation. PMID 31624351 DOI: 10.1038/S41418-019-0432-4  0.37
2019 Dong L, Reljic B, Cheung JG, Ng ES, Lindqvist LM, Elefanty AG, Vaux DL, Tran H. In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose. Cell Death and Differentiation. PMID 30770875 DOI: 10.1038/S41418-019-0275-Z  0.369
2019 Frank D, Vaux DL, Murphy JM, Vince JE, Lindqvist LM. Necroptotic MLKL attenuates autophagy following its translocation to intracellular membranes. Journal of Cell Science. PMID 30709919 DOI: 10.1242/Jcs.220996  0.408
2018 Strasser A, Vaux DL. Viewing BCL2 and cell death control from an evolutionary perspective. Cell Death and Differentiation. 25: 13-20. PMID 31745323 DOI: 10.1038/cdd.2017.145  0.392
2018 Lalaoui N, Vaux DL. Recent advances in understanding inhibitor of apoptosis proteins. F1000research. 7: 1889. PMID 30631429 DOI: 10.12688/F1000Research.16439.1  0.468
2018 Strasser A, Vaux DL. Viewing BCL2 and cell death control from an evolutionary perspective. Cell Death and Differentiation. 25: 13-20. PMID 29099481 DOI: 10.1038/Cdd.2017.145  0.489
2017 Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL. Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Cell Death and Differentiation. PMID 29229994 DOI: 10.1038/S41418-017-0017-Z  0.459
2017 Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J. Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. The Journal of Biological Chemistry. 292: 14310. PMID 28842477 DOI: 10.1074/jbc.A109.087635  0.329
2017 Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, ... ... Vaux DL, et al. XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation. Cell Reports. 20: 668-682. PMID 28723569 DOI: 10.1016/J.Celrep.2017.06.073  0.42
2017 Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096356 DOI: 10.1073/Pnas.1613305114  0.464
2017 Fischer K, Masouras D, Daunt C, Dias S, Ekert P, Strasser A, Vaux D, Jabbour A. Cytokine signalling in haematopoietic cells Experimental Hematology. 53. DOI: 10.1016/J.Exphem.2017.06.262  0.305
2016 Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA. Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins. Plos One. 11: e0164003. PMID 27806040 DOI: 10.1371/Journal.Pone.0164003  0.507
2016 Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM. Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion. Cell Death & Differentiation. 23: 1827-1838. PMID 27419363 DOI: 10.1038/Cdd.2016.69  0.4
2016 Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, ... ... Vaux DL, et al. The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia. Science Translational Medicine. 8: 339ra69. PMID 27194727 DOI: 10.1126/Scitranslmed.Aad3099  0.502
2016 Reljic B, Conos S, Lee EF, Garnier JM, Dong L, Lessene G, Fairlie WD, Vaux DL, Lindqvist LM. BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux. Autophagy. 0. PMID 27172402 DOI: 10.1080/15548627.2016.1179406  0.436
2016 Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM. Evolutionary divergence of the necroptosis effector MLKL. Cell Death and Differentiation. PMID 26868910 DOI: 10.1038/Cdd.2015.169  0.408
2016 Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NN, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, ... ... Vaux DL, et al. Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics. Cancer Cell. 29: 145-158. PMID 26859455 DOI: 10.1016/J.Ccell.2016.01.006  0.364
2016 Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8. The Journal of Biological Chemistry. 291: 2547. PMID 26826208 DOI: 10.1074/Jbc.A110.216226  0.415
2016 Delbridge AR, Grabow S, Strasser A, Vaux DL. Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. Nature Reviews. Cancer. 16: 99-109. PMID 26822577 DOI: 10.1038/Nrc.2015.17  0.409
2015 Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekra W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, ... ... Vaux DL, et al. TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase-1. Elife. 4. PMID 26701909 DOI: 10.7554/Elife.10592  0.351
2015 Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, ... ... Vaux DL, et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nature Communications. 6: 6282. PMID 25693118 DOI: 10.1038/Ncomms7282  0.494
2015 Silke J, Vaux DL. IAP gene deletion and conditional knockout models. Seminars in Cell & Developmental Biology. 39: 97-105. PMID 25545814 DOI: 10.1016/J.Semcdb.2014.12.004  0.33
2015 Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, ... ... Vaux DL, et al. Author response: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 Elife. DOI: 10.7554/Elife.10592.018  0.333
2014 Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, ... ... Vaux DL, et al. TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. Elife. 3. PMID 25443632 DOI: 10.7554/Elife.03464  0.457
2014 Lindqvist LM, Vaux DL. BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy. Autophagy. 10: 1474-5. PMID 24991825 DOI: 10.4161/Auto.29639  0.506
2014 Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, et al. Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. Embo Reports. 15: 982-90. PMID 24990442 DOI: 10.15252/Embr.201438463  0.437
2014 Lindqvist LM, Heinlein M, Huang DC, Vaux DL. Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak. Proceedings of the National Academy of Sciences of the United States of America. 111: 8512-7. PMID 24912196 DOI: 10.1073/Pnas.1406425111  0.529
2014 Cook WD, Moujalled DM, Ralph TJ, Lock P, Young SN, Murphy JM, Vaux DL. RIPK1- and RIPK3-induced cell death mode is determined by target availability. Cell Death and Differentiation. 21: 1600-12. PMID 24902899 DOI: 10.1038/Cdd.2014.70  0.508
2014 Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, ... ... Vaux DL, et al. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 157: 1175-88. PMID 24813849 DOI: 10.1016/J.Cell.2014.04.019  0.387
2014 Moujalled DM, Cook WD, Murphy JM, Vaux DL. Necroptosis induced by RIPK3 requires MLKL but not Drp1. Cell Death & Disease. 5: e1086. PMID 24577084 DOI: 10.1038/Cddis.2014.18  0.515
2014 Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J. cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 123: 2562-72. PMID 24497535 DOI: 10.1182/Blood-2013-06-510743  0.455
2014 Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, ... ... Vaux DL, et al. Author response: TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice Elife. DOI: 10.7554/Elife.03464.016  0.385
2014 Lawlor K, Mildenhall A, Condon S, Silke J, Vaux D, Vince J. 193: Inhibitor of apoptosis (IAP) proteins ubiquitylate RIP3 kinase and repress apoptosis, necroptosis, NLRP3 inflammasome activation and systemic inflammation Cytokine. 70: 74. DOI: 10.1016/J.Cyto.2014.07.200  0.482
2014 Etemadi N, Rickard J, Anderton H, Spall S, Hall C, Vaux D, Nachbur U, Silke J. 47: TRAF2 regulates NFkB transcription factors to inhibit cell death and inflammation in the skin Cytokine. 70: 39. DOI: 10.1016/J.Cyto.2014.07.054  0.325
2013 Vaux DL. Another twist in the on and off affair between cell suicide and inflammation. Cell Death & Differentiation. 20: 974-975. PMID 23832149 DOI: 10.1038/Cdd.2013.57  0.527
2013 Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL. TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1. Cell Death & Disease. 4: e465. PMID 23328672 DOI: 10.1038/Cddis.2012.201  0.48
2012 Moulin M, Anderton H, Voss AK, Thomas T, Wong WW, Bankovacki A, Feltham R, Chau D, Cook WD, Silke J, Vaux DL. IAPs limit activation of RIP kinases by TNF receptor 1 during development. The Embo Journal. 31: 1679-91. PMID 22327219 DOI: 10.1038/Emboj.2012.18  0.39
2012 Moujalled DM, Cook WD, Lluis JM, Khan NR, Ahmed AU, Callus BA, Vaux DL. In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it. Cell Death and Differentiation. 19: 808-15. PMID 22095280 DOI: 10.1038/Cdd.2011.151  0.496
2011 Feltham R, Bettjeman B, Budhidarmo R, Mace PD, Shirley S, Condon SM, Chunduru SK, McKinlay MA, Vaux DL, Silke J, Day CL. Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. The Journal of Biological Chemistry. 286: 17015-28. PMID 21393245 DOI: 10.1074/Jbc.M111.222919  0.338
2011 Gentle IE, Wong WWL, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8 Journal of Biological Chemistry. 286: 13282-13291. PMID 21339290 DOI: 10.1074/Jbc.M110.216226  0.49
2011 Gardam S, Turner VM, Anderton H, Limaye S, Basten A, Koentgen F, Vaux DL, Silke J, Brink R. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 117: 4041-51. PMID 21300983 DOI: 10.1182/Blood-2010-10-312793  0.365
2011 Vaux DL. Apoptogenic factors released from mitochondria. Biochimica Et Biophysica Acta. 1813: 546-50. PMID 20713095 DOI: 10.1016/J.Bbamcr.2010.08.002  0.44
2010 Lazarou M, Stojanovski D, Frazier AE, Kotevski A, Dewson G, Craigen WJ, Kluck RM, Vaux DL, Ryan MT. Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor. The Journal of Biological Chemistry. 285: 36876-83. PMID 20851889 DOI: 10.1074/Jbc.M110.159301  0.382
2010 Mace PD, Smits C, Vaux DL, Silke J, Day CL. Asymmetric recruitment of cIAPs by TRAF2. Journal of Molecular Biology. 400: 8-15. PMID 20447407 DOI: 10.1016/J.Jmb.2010.04.055  0.346
2010 Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J. Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. The Journal of Biological Chemistry. 285: 17525-36. PMID 20356846 DOI: 10.1074/Jbc.M109.087635  0.439
2010 Lluis JM, Nachbur U, Cook WD, Gentle IE, Moujalled D, Moulin M, Wong WW, Khan N, Chau D, Callus BA, Vince JE, Silke J, Vaux DL. TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. Plos One. 5: e8620. PMID 20062539 DOI: 10.1371/Journal.Pone.0008620  0.468
2010 Wong WW, Gentle IE, Nachbur U, Anderton H, Vaux DL, Silke J. RIPK1 is not essential for TNFR1-induced activation of NF-kappaB. Cell Death & Differentiation. 17: 482-487. PMID 19927158 DOI: 10.1038/Cdd.2009.178  0.409
2009 Vaux DL. Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer. F1000 Biology Reports. 1: 79. PMID 20948609 DOI: 10.3410/B1-79  0.41
2009 Kotevski A, Cook WD, Vaux DL, Callus BA. Identification of an Xiap-like pseudogene on mouse chromosome 7. Plos One. 4: e8078. PMID 19956646 DOI: 10.1371/Journal.Pone.0008078  0.332
2009 Vince JE, Pantaki D, Feltham R, Mace PD, Cordier SM, Schmukle AC, Davidson AJ, Callus BA, Wong WW, Gentle IE, Carter H, Lee EF, Walczak H, Day CL, Vaux DL, et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. The Journal of Biological Chemistry. 284: 35906-15. PMID 19815541 DOI: 10.1074/Jbc.M109.072256  0.394
2009 Ahmed AU, Moulin M, Coumailleau F, Wong WW, Miasari M, Carter H, Silke J, Cohen-Tannoudji M, Vince JE, Vaux DL. CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha. Current Biology : Cb. 19: R15-7; author reply . PMID 19138581 DOI: 10.1016/J.Cub.2008.11.040  0.393
2009 Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA, Callus BA, Lopez A, Strasser A, Vaux DL, Ekert PG. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death and Differentiation. 16: 555-63. PMID 19079139 DOI: 10.1038/Cdd.2008.179  0.487
2008 Callus BA, Moujallad DM, Silke J, Gerl R, Jabbour AM, Ekert PG, Vaux DL. Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins. Journal of Molecular Biology. 384: 313-23. PMID 18835564 DOI: 10.1016/J.Jmb.2008.09.041  0.548
2008 Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL. Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. The Journal of Biological Chemistry. 283: 31633-40. PMID 18784070 DOI: 10.1074/Jbc.M804753200  0.353
2008 Vince JE, Chau D, Callus B, Wong WW, Hawkins CJ, Schneider P, McKinlay M, Benetatos CA, Condon SM, Chunduru SK, Yeoh G, Brink R, Vaux DL, Silke J. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. The Journal of Cell Biology. 182: 171-84. PMID 18606850 DOI: 10.1083/Jcb.200801010  0.446
2008 Vaux DL. ABT-737, proving to be a great tool even before it is proven in the clinic. Cell Death & Differentiation. 15: 807-808. PMID 18408737 DOI: 10.1038/Cdd.2008.31  0.506
2008 Callus BA, Ekert PG, Heraud JE, Jabbour AM, Kotevski A, Vince JE, Silke J, Vaux DL. Cytoplasmic p53 is not required for PUMA-induced apoptosis. Cell Death and Differentiation. 15: 213-5; author reply . PMID 17992194 DOI: 10.1038/Sj.Cdd.4402245  0.423
2008 Callus BA, Moujallad DM, Silke J, Gerl R, Jabbour AM, Ekert PG, Vaux DL. Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins Journal of Molecular Biology. DOI: 10.1016/j.jmb.2008.09.041  0.462
2007 Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, ... ... Vaux DL, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell. 131: 682-93. PMID 18022363 DOI: 10.1016/J.Cell.2007.10.037  0.48
2007 Callus BA, Vaux DL. Caspase inhibitors: viral, cellular and chemical. Cell Death & Differentiation. 14: 73-78. PMID 16946729 DOI: 10.1038/Sj.Cdd.4402034  0.501
2007 Verhagen AM, Kratina TK, Hawkins CJ, Silke J, Ekert PG, Vaux DL. Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs. Cell Death & Differentiation. 14: 348-357. PMID 16794601 DOI: 10.1038/Sj.Cdd.4402001  0.391
2006 Jabbour AM, Puryer MA, Yu JY, Lithgow T, Riffkin CD, Ashley DM, Vaux DL, Ekert PG, Hawkins CJ. Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1. Journal of Cell Science. 119: 2572-82. PMID 16735440 DOI: 10.1242/Jcs.02985  0.55
2006 Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL. Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood. 108: 1461-8. PMID 16705087 DOI: 10.1182/Blood-2006-03-014209  0.4
2006 Vaux DL, Strasser A. Programmed Cell Death Reviews in Cell Biology and Molecular Medicine. DOI: 10.1002/3527600906.Mcb.200400090  0.512
2005 Silke J, Kratina T, Chu D, Ekert PG, Day CL, Pakusch M, Huang DC, Vaux DL. Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proceedings of the National Academy of Sciences of the United States of America. 102: 16182-7. PMID 16263936 DOI: 10.1073/Pnas.0502828102  0.421
2005 Ekert PG, Vaux DL. The mitochondrial death squad: hardened killers or innocent bystanders? Current Opinion in Cell Biology. 17: 626-30. PMID 16219456 DOI: 10.1016/J.Ceb.2005.09.001  0.411
2005 Vaux DL, Silke J. IAPs--the ubiquitin connection. Cell Death & Differentiation. 12: 1205-1207. PMID 16094398 DOI: 10.1038/Sj.Cdd.4401696  0.305
2005 Burri L, Strahm Y, Hawkins CJ, Gentle IE, Puryer MA, Verhagen A, Callus B, Vaux D, Lithgow T. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Molecular Biology of the Cell. 16: 2926-33. PMID 15814844 DOI: 10.1091/Mbc.E04-12-1086  0.337
2005 Vaux DL, Silke J. IAPs, RINGs and ubiquitylation. Nature Reviews. Molecular Cell Biology. 6: 287-97. PMID 15803136 DOI: 10.1038/Nrm1621  0.345
2005 Gerl R, Vaux DL. Apoptosis in the development and treatment of cancer Carcinogenesis. 26: 263-270. PMID 15375012 DOI: 10.1093/Carcin/Bgh283  0.439
2005 Gillespie M, Vaux D. Extrinsic Pathway for Apoptosis Reactome - a Curated Knowledgebase of Biological Pathways. 15. DOI: 10.3180/1934-1792/React_1059.1  0.341
2004 Ekert PG, Read SH, Silke J, Marsden VS, Kaufmann H, Hawkins CJ, Gerl R, Kumar S, Vaux DL. Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. The Journal of Cell Biology. 165: 835-42. PMID 15210730 DOI: 10.1083/Jcb.200312031  0.523
2004 Marsden VS, Ekert PG, Van Delft M, Vaux DL, Adams JM, Strasser A. Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9. The Journal of Cell Biology. 165: 775-80. PMID 15210727 DOI: 10.1083/Jcb.200312030  0.66
2004 Silke J, Kratina T, Ekert PG, Pakusch M, Vaux DL. Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis. The Journal of Biological Chemistry. 279: 4313-21. PMID 14570909 DOI: 10.1074/Jbc.M305661200  0.54
2003 Vaux DL, Silke J. HtrA2/Omi, a sheep in wolf's clothing. Cell. 115: 251-3. PMID 14636553 DOI: 10.1016/S0092-8674(03)00851-1  0.469
2003 Kaufmann SH, Vaux DL. Alterations in the apoptotic machinery and their potential role in anticancer drug resistance. Oncogene. 22: 7414-30. PMID 14576849 DOI: 10.1038/Sj.Onc.1206945  0.526
2003 Vaux DL, Silke J. Mammalian mitochondrial IAP binding proteins. Biochemical and Biophysical Research Communications. 304: 499-504. PMID 12729584 DOI: 10.1016/S0006-291X(03)00622-3  0.444
2002 Vaux DL. Apoptosis and toxicology - what relevance? Toxicology. 164: 3-7. PMID 12505277 DOI: 10.1016/S0300-483X(02)00248-2  0.494
2002 Read SH, Baliga BC, Ekert PG, Vaux DL, Kumar S. A novel Apaf-1-independent putative caspase-2 activation complex. The Journal of Cell Biology. 159: 739-45. PMID 12460989 DOI: 10.1083/Jcb.200209004  0.488
2002 Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, Roy S, Nicholson DW, Vaux DL, Bouillet P, Adams JM, et al. Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 419: 634-7. PMID 12374983 DOI: 10.1038/Nature01101  0.663
2002 Kumar S, Vaux DL. Apoptosis. A cinderella caspase takes center stage. Science (New York, N.Y.). 297: 1290-1. PMID 12193776 DOI: 10.1126/Science.1076118  0.45
2002 O'Reilly LA, Ekert P, Harvey N, Marsden V, Cullen L, Vaux DL, Hacker G, Magnusson C, Pakusch M, Cecconi F, Kuida K, Strasser A, Huang DC, Kumar S. Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death and Differentiation. 9: 832-41. PMID 12107826 DOI: 10.1038/Sj.Cdd.4401033  0.493
2002 Tikoo A, O'Reilly L, Day CL, Verhagen AM, Pakusch M, Vaux DL. Tissue distribution of Diablo/Smac revealed by monoclonal antibodies Cell Death & Differentiation. 9: 710-716. PMID 12058276 DOI: 10.1038/Sj.Cdd.4401031  0.4
2002 Vaux DL. Apoptosis timeline. Cell Death and Differentiation. 9: 349-54. PMID 11965486 DOI: 10.1038/sj.cdd.4400990  0.378
2002 Silke J, Hawkins CJ, Ekert PG, Chew J, Day CL, Pakusch M, Verhagen AM, Vaux DL. The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites. The Journal of Cell Biology. 157: 115-24. PMID 11927604 DOI: 10.1083/Jcb.200108085  0.482
2002 Verhagen AM, Vaux DL. Cell death regulation by the mammalian IAP antagonist Diablo/Smac. Apoptosis. 7: 163-166. PMID 11865200 DOI: 10.1023/A:1014318615955  0.517
2002 Vaux DL. The buzz about BAFF. The Journal of Clinical Investigation. 109: 17-8. PMID 11781346 DOI: 10.1172/Jci14780  0.365
2002 Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. The Journal of Biological Chemistry. 277: 445-54. PMID 11604410 DOI: 10.1074/Jbc.M109891200  0.507
2001 Verhagen AM, Coulson EJ, Vaux DL. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biology. 2: REVIEWS3009. PMID 11516343 DOI: 10.1186/Gb-2001-2-7-Reviews3009  0.481
2001 Silke J, Ekert PG, Day CL, Hawkins CJ, Baca M, Chew J, Pakusch M, Verhagen AM, Vaux DL. Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP. The Embo Journal. 20: 3114-3123. PMID 11406588 DOI: 10.1093/Emboj/20.12.3114  0.476
2001 Ekert PG, Silke JH, Hawkins CJ, Verhagen A, Vaux D. DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9. Journal of Cell Biology. 152: 483-490. PMID 11157976 DOI: 10.1083/Jcb.152.3.483  0.508
2001 Vaux DL, Flavell RA. Apoptosis genes and autoimmunity. Current Opinion in Immunology. 12: 719-24. PMID 11102778 DOI: 10.1016/S0952-7915(00)00168-0  0.434
2001 Vaux DL. Proceeding to the death Trends in Cell Biology. 11: 274-275. DOI: 10.1016/S0962-8924(01)01989-4  0.401
2000 Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KHA. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype Current Biology. 10: 1319-1328. PMID 11084331 DOI: 10.1016/S0960-9822(00)00769-7  0.436
2000 Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins Cell. 102: 43-53. PMID 10929712 DOI: 10.1016/S0092-8674(00)00009-X  0.394
2000 Strasser A, Vaux DL. Death in the snow: report on Keystone Conference on 'Apoptosis and Programmed Cell Death' at Breckenridge, CO, April 6-11th 1999. Biochimica Et Biophysica Acta. 1470. PMID 10656989 DOI: 10.1016/S0304-419X(99)00029-3  0.452
2000 Day CL, Vaux DL, Hinds MG. Structural analysis of caspase recruitment domains (CARDs) Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A456  0.342
1999 Day C, Dupont C, Lackmann M, Vaux D, Hinds M. Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1 Cell Death & Differentiation. 6: 1125-1132. PMID 10578182 DOI: 10.1038/Sj.Cdd.4400584  0.367
1999 Uren AG, Beilharz T, O'Connell MJ, Bugg SJ, Van Driel R, Vaux DL, Lithgow T. Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division Proceedings of the National Academy of Sciences of the United States of America. 96: 10170-10175. PMID 10468581 DOI: 10.1073/Pnas.96.18.10170  0.486
1999 Hinds MG, Norton RS, Vaux DL, Day CL. Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat. Nature Structural & Molecular Biology. 6: 648-651. PMID 10404221 DOI: 10.1038/10701  0.425
1999 Vaux DL. Caspases and apoptosis - biology and terminology. Cell Death & Differentiation. 6: 493-494. PMID 10381650 DOI: 10.1038/Sj.Cdd.4400523  0.479
1999 Magnusson C, Vaux DL. Signalling by CD95 and TNF receptors: not only life and death Immunology and Cell Biology. 77: 41-46. PMID 10101685 DOI: 10.1046/J.1440-1711.1999.00800.X  0.388
1999 Vaux DL, Korsmeyer SJ. Cell death in development. Cell. 96: 245-54. PMID 9988219 DOI: 10.1016/S0092-8674(00)80564-4  0.312
1999 Verhagen AM, Vaux DL. Molecular mechanisms of apoptosis: an overview. Results and Problems in Cell Differentiation. 23: 11-24. PMID 9950027 DOI: 10.1007/978-3-540-69184-6_2  0.514
1999 Ekert PG, Silke J, Vaux DL. Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors The Embo Journal. 18: 330-338. PMID 9889190 DOI: 10.1093/Emboj/18.2.330  0.523
1999 Ekert PG, Silke J, Vaux DL. Genes Inhibiting Caspases Rescue Neuronal Cells from Apoptosis and Allow Functional Survival of Cells Exposed to a Death Stimulus Pediatric Research. 45: 195-195. DOI: 10.1203/00006450-199904020-01161  0.481
1998 Hawkins CJ, Ekert PG, Uren AG, Holmgreen SP, Vaux DL. Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells Cell Death and Differentiation. 5: 569-576. PMID 10200511 DOI: 10.1038/Sj.Cdd.4400389  0.535
1998 Silke J, Vaux DL. Cell death: Shadow Baxing Current Biology. 8. PMID 9705928 DOI: 10.1016/S0960-9822(07)00339-9  0.449
1998 Uren AG, Coulson EJ, Vaux DL. Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts Trends in Biochemical Sciences. 23: 159-162. PMID 9612077 DOI: 10.1016/S0968-0004(98)01198-0  0.34
1998 Vaux DL. Immunopathology of apoptosis —introduction and overview Springer Seminars in Immunopathology. 19: 271-278. PMID 9540156 DOI: 10.1007/Bf00787224  0.502
1998 Ekert PG, Huang D, Vaux DL. Cloning and testing new genes to block specific caspase family members.† 998 Pediatric Research. 43: 172-172. DOI: 10.1203/00006450-199804001-01019  0.504
1997 Häcker G, Vaux DL. A chronology of cell death. Apoptosis. 2: 247-256. PMID 14646538 DOI: 10.1023/A:1026480902371  0.465
1997 Ekert PG, Vaux DL. Apoptosis, haemopoiesis and leukaemogenesis. BaillièRe's Clinical Haematology. 10: 561-576. PMID 9421616 DOI: 10.1016/S0950-3536(97)80026-1  0.516
1997 Strasser A, Huang DCS, Vaux DL. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy Biochimica Et Biophysica Acta. 1333. PMID 9395285 DOI: 10.1016/S0304-419X(97)00019-X  0.469
1997 Ekert PG, Vaux DL. Apoptosis and the immune system British Medical Bulletin. 53: 591-603. PMID 9374039 DOI: 10.1093/Oxfordjournals.Bmb.A011632  0.439
1997 Vaux DL, Wilhelm S, Häcker G. Requirements for proteolysis during apoptosis. Molecular and Cellular Biology. 17: 6502-6507. PMID 9343413 DOI: 10.1128/Mcb.17.11.6502  0.432
1997 Vaux DL. CED-4--the third horseman of apoptosis. Cell. 90: 389-390. PMID 9267018 DOI: 10.1016/S0092-8674(00)80497-3  0.486
1997 Uren AG, Vaux DL. Viral Inhibitors of Apoptosis Vitamins and Hormones. 53: 175-193. PMID 9197181 DOI: 10.1016/S0083-6729(08)60707-4  0.439
1997 Irmler M, Hofmann K, Vaux D, Tschopp J. Direct Physical Interaction Between The Caenorhabditis Elegans 'Death Proteins' Ced-3 And Ced-4 Febs Letters. 406: 189-190. PMID 9109415 DOI: 10.1016/S0014-5793(97)00271-8  0.401
1997 Allison J, Georgiou HM, Strasser A, Vaux DL. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proceedings of the National Academy of Sciences of the United States of America. 94: 3943-7. PMID 9108084 DOI: 10.1073/Pnas.94.8.3943  0.364
1997 Hawkins CJ, Vaux DL. The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system Seminars in Immunology. 9: 25-33. PMID 9106305 DOI: 10.1006/Smim.1996.0052  0.503
1996 Uren AG, Vaux DL. Molecular and clinical aspects of apoptosis Pharmacology and Therapeutics. 72: 37-50. PMID 8981570 DOI: 10.1016/S0163-7258(96)00098-8  0.414
1996 Hawkins CJ, Uren AG, Häcker G, Medcalf RL, Vaux DL. Inhibition of interleukin 1β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP Proceedings of the National Academy of Sciences of the United States of America. 93: 13786-13790. PMID 8943013 DOI: 10.1073/Pnas.93.24.13786  0.467
1996 Vaux DL, Whitney D, Weissman IL. Activation of physiological cell death mechanisms by a necrosis-causing agent. Microscopy Research and Technique. 34: 259-66. PMID 8743413 DOI: 10.1002/(Sici)1097-0029(19960615)34:3<259::Aid-Jemt8>3.0.Co;2-K  0.602
1996 Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proceedings of the National Academy of Sciences of the United States of America. 93: 4974-8. PMID 8643514 DOI: 10.1073/Pnas.93.10.4974  0.468
1996 Vaux DL, Strasser A. The molecular biology of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 93: 2239-2244. PMID 8637856 DOI: 10.1073/Pnas.93.6.2239  0.495
1996 Smith KGC, Strasser A, Vaux DL. CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease. The Embo Journal. 15: 5167-5176. DOI: 10.1002/J.1460-2075.1996.Tb00901.X  0.346
1995 Vaux DL, Häcker G. Hypothesis: apoptosis caused by cytotoxins represents a defensive response that evolved to combat intracellular pathogens. Clinical and Experimental Pharmacology and Physiology. 22: 861-863. PMID 8593745 DOI: 10.1111/J.1440-1681.1995.Tb01951.X  0.515
1995 Vaux DL, Häcker G. Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid and myeloid cells. Dna and Cell Biology. 14: 189-193. PMID 7880439 DOI: 10.1089/Dna.1995.14.189  0.482
1995 Häcker G, Vaux DL. Apoptosis: A sticky business Current Biology. 5: 622-624. PMID 7552172 DOI: 10.1016/S0960-9822(95)00126-6  0.426
1995 Häucker G, Vaux DL. The medical significance of physiological cell death Medicinal Research Reviews. 15: 299-311. PMID 7475505 DOI: 10.1002/Med.2610150404  0.368
1994 Yin D, Kondo S, Takeuchi J, Morimura T, Vaux D. Bcl-2 gene prevents apoptosis in murine acth-secreting adenoma cells induced by bromocriptine. International Journal of Oncology. 4: 187-91. PMID 21566911 DOI: 10.3892/Ijo.4.1.187  0.457
1994 Haecker G, Vaux DL. Viral, worm and radical implications for apoptosis. Trends in Biochemical Sciences. 19: 99-100. PMID 8203023 DOI: 10.1016/0968-0004(94)90197-X  0.386
1994 Qian F, Vaux DL, Weissman IL. Expression of the integrin alpha 4 beta 1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell. 77: 335-47. PMID 8181055 DOI: 10.1016/0092-8674(94)90149-X  0.383
1994 Vaux DL, Haecker G, Strasser A. An evolutionary perspective on apoptosis. Cell. 76: 777-9. PMID 8124715 DOI: 10.1016/0092-8674(94)90350-6  0.459
1994 Ragland BD, Ashley LS, Vaux DL, Petri WA. Entamoeba histolytica: target cells killed by trophozoites undergo DNA fragmentation which is not blocked by Bcl-2. Experimental Parasitology. 79: 460-7. PMID 7957763 DOI: 10.1006/Expr.1994.1107  0.482
1994 Hawkins CJ, Vaux DL. Analysis of the Role of bcl‐2 in Apoptosis Immunological Reviews. 142: 127-139. PMID 7698791 DOI: 10.1111/J.1600-065X.1994.Tb00886.X  0.533
1994 Häcker G, Vaux DL. Expression of candidate cell death genes in cell lines during apoptosis. Biochemistry and Cell Biology. 72: 451-454. PMID 7654317 DOI: 10.1139/O94-060  0.461
1993 Vaux DL. Toward an understanding of the molecular mechanisms of physiological cell death. Proceedings of the National Academy of Sciences of the United States of America. 90: 786-789. PMID 8430086 DOI: 10.1073/Pnas.90.3.786  0.522
1993 Vaux DL, Weissman IL. Neither macromolecular synthesis nor myc is required for cell death via the mechanism that can be controlled by Bcl-2. Molecular and Cellular Biology. 13: 7000-5. PMID 7692234 DOI: 10.1128/Mcb.13.11.7000  0.599
1993 Vaux DL, Weissman IL, Kim SK. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science (New York, N.Y.). 258: 1955-7. PMID 1470921 DOI: 10.1126/Science.1470921  0.545
1992 Vaux DL, Aguila HL, Weissman IL. Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing. International Immunology. 4: 821-4. PMID 1498090 DOI: 10.1093/Intimm/4.7.821  0.585
1991 Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, Harris AW. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. 88: 8661-5. PMID 1924327 DOI: 10.1073/Pnas.88.19.8661  0.548
1990 Vaux DL, Lalor PA, Cory S, Johnson GR. In vivo expression of interleukin 5 induces an eosinophilia and expanded Ly-1B lineage populations. International Immunology. 2: 965-971. PMID 2078522 DOI: 10.1093/Intimm/2.10.965  0.311
1990 Strasser A, Harris AW, Vaux DL, Webb E, Bath ML, Adams JM, Cory S. Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice. Current Topics in Microbiology and Immunology. 166: 175-81. PMID 2073796 DOI: 10.1007/978-3-642-75889-8_22  0.541
1989 Adams JM, Harris AW, Langdon WY, Klinken SP, Kongsuwan K, Alexander WS, Hariharan I, Vaux D, Rosenbaum H, Crawford M. Lymphoid neoplasia and the control of haemopoietic differentiation. Ciba Foundation Symposium. 142: 54-64; discussion 65. PMID 2568245  0.502
1989 Adams JM, Cory S, Harris A, Langdon W, Klinken P, Alexander W, Kongsuwan K, Webb E, Rosenbaum H, Vaux D, Walter JA, Hall E. Oncogene impact on haemopoietic cells Mechanisms of Development. 27: 178. DOI: 10.1016/0922-3371(89)90540-6  0.337
1988 Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 335: 440-2. PMID 3262202 DOI: 10.1038/335440A0  0.601
1988 Harris AW, Langdon WY, Alexander WS, Hariharan IK, Rosenbaum H, Vaux D, Webb E, Bernard O, Crawford M, Abud H. Transgenic mouse models for hematopoietic tumorigenesis. Current Topics in Microbiology and Immunology. 141: 82-93. PMID 3215058 DOI: 10.1007/978-3-642-74006-0_12  0.339
1982 Pike BL, Vaux DL, Clark-Lewis I, Schrader JW, Nossal GJ. Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor Proceedings of the National Academy of Sciences of the United States of America. 79: 6350-6354. PMID 6983069 DOI: 10.1073/Pnas.79.20.6350  0.313
1981 Vaux DL, Pike BL, Nossal GJV. Antibody production by single, hapten-specific B lymphocytes: an antigen-driven cloning system free of filler or accessory cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 7702-7706. PMID 6174979 DOI: 10.1073/Pnas.78.12.7702  0.309
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