Peter M. Blumberg - Publications

Affiliations: 
NIH (NCI) 

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Blanco FA, Czikora A, Kedei N, You Y, Mitchell GA, Pany S, Ghosh A, Blumberg PM, Das J. Munc13 Is a Molecular Target of Bryostatin 1. Biochemistry. PMID 31243993 DOI: 10.1021/acs.biochem.9b00427  0.48
2018 Ann J, Czikora A, Saini A, Zhou X, Mitchell GA, Lewin NE, Peach ML, Blumberg PM, Lee J. α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine Releasing Protein 3 (RasGRP3) Ligands. Journal of Medicinal Chemistry. PMID 29860841 DOI: 10.1021/acs.jmedchem.8b00661  0.48
2018 Zhao X, Kedei N, Michalowski AM, Lewin NE, Keck GE, Blumberg PM. Deletion of the C-26 Methyl Substituent from the Bryostatin Analogue Merle 23 has Negligible Impact on Its Biological Profile or Potency. Chembiochem : a European Journal of Chemical Biology. PMID 29517836 DOI: 10.1002/cbic.201700677  0.48
2018 Cummins TJ, Kedei N, Czikora A, Lewin NE, Kirk S, Petersen ME, McGowan KM, Chen JQ, Luo X, Johnson RC, Ravichandran S, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues. Chembiochem : a European Journal of Chemical Biology. PMID 29424951 DOI: 10.1002/cbic.201700655  0.48
2018 Czikora A, Pany S, You Y, Saini AS, Lewin NE, Mitchell GA, Abramovitz A, Kedei N, Blumberg PM, Das J. Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta. Biochimica Et Biophysica Acta. PMID 29317197 DOI: 10.1016/j.bbamem.2018.01.007  0.48
2017 Das J, Kedei N, Kelsey JS, You Y, Pany S, Mitchell GA, Lewin NE, Blumberg PM. Critical role of Trp-588 of presynaptic Munc13-1 for ligand binding and membrane translocation. Biochemistry. PMID 29244485 DOI: 10.1021/acs.biochem.7b00764  0.48
2017 Czikora A, Kedei N, Kalish H, Blumberg PM. Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3. Biochimica Et Biophysica Acta. 1859: 2350-2360. PMID 28912101 DOI: 10.1016/j.bbamem.2017.09.010  0.48
2017 Elhalem E, Donadío LG, Zhou X, Lewin NE, Garcia LC, Lai CC, Kelley JA, Peach ML, Blumberg PM, Comin MJ. Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP. Bioorganic & Medicinal Chemistry. PMID 28392275 DOI: 10.1016/j.bmc.2017.03.022  0.48
2016 Petersen ME, Kedei N, Lewin NE, Blumberg PM, Keck GE. Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC. Tetrahedron Letters. 57: 4749-4753. PMID 27713589 DOI: 10.1016/j.tetlet.2016.09.040  0.48
2016 Ketcham JM, Volchkov I, Chen TY, Blumberg PM, Kedei N, Lewin NE, Krische MJ. Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology. Journal of the American Chemical Society. PMID 27676096 DOI: 10.1021/jacs.6b08695  0.64
2016 Baumann DO, McGowan KM, Kedei N, Peach ML, Blumberg PM, Keck GE. Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-ring. The Journal of Organic Chemistry. PMID 27494208 DOI: 10.1021/acs.joc.6b01516  0.48
2016 Ann J, Sun W, Zhou X, Jung A, Baek J, Lee S, Kim C, Yoon S, Hong S, Choi S, Turcios NA, Herold BK, Esch TE, Lewin NE, Abramovitz A, ... ... Blumberg PM, et al. Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template. Bioorganic & Medicinal Chemistry Letters. PMID 27317643 DOI: 10.1016/j.bmcl.2016.06.010  0.48
2016 Czikora A, Lundberg DJ, Abramovitz A, Lewin NE, Kedei N, Peach ML, Zhou X, Merritt RC, Craft EA, Braun DC, Blumberg PM. Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity. The Journal of Biological Chemistry. PMID 27022025 DOI: 10.1074/jbc.M116.725333  0.48
2016 Feng Z, Pearce LV, Zhang Y, Xing C, Herold BK, Ma S, Hu Z, Turcios NA, Yang P, Tong Q, McCall AK, Blumberg PM, Xie XQ. Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation. The Aaps Journal. PMID 27000851 DOI: 10.1208/s12248-016-9888-z  0.64
2016 Ann J, Ki Y, Yoon S, Kim MS, Lee JU, Kim C, Lee S, Jung A, Baek J, Hong S, Choi S, Pearce LV, Esch TE, Turcios NA, Lewin NE, ... ... Blumberg PM, et al. 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 26860926 DOI: 10.1016/j.bmc.2016.01.051  0.48
2016 Kelsey JS, Cataisson C, Chen J, Herrmann MA, Petersen ME, Baumann DA, McGowan KM, Yuspa SH, Keck GE, Blumberg PM. Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin. Molecular Carcinogenesis. PMID 26859836 DOI: 10.1002/mc.22460  0.48
2015 Ann J, Jung A, Kim MY, Kim HM, Ryu H, Kim S, Kang DW, Hong S, Cui M, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, Christoph T, et al. Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry. PMID 26474664 DOI: 10.1016/j.bmc.2015.10.001  0.64
2015 Tran PT, Kim HS, Ann J, Kim SE, Kim C, Hong M, Hoang VH, Ngo VT, Hong S, Cui M, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, et al. α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 2326-30. PMID 25937016 DOI: 10.1016/j.bmcl.2015.04.024  0.64
2015 Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM. Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships. Journal of Natural Products. 78: 896-900. PMID 25808573 DOI: 10.1021/acs.jnatprod.5b00094  0.64
2015 Lee HK, Finniss S, Cazacu S, Xiang C, Poisson LM, Blumberg PM, Brodie C. RasGRP3 regulates the migration of glioma cells via interaction with Arp3. Oncotarget. 6: 1850-64. PMID 25682201  0.64
2015 Ryu H, Seo S, Lee JY, Ha TH, Lee S, Jung A, Ann J, Kim SE, Yoon S, Hong M, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Schiene K, Stockhausen H, et al. Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. European Journal of Medicinal Chemistry. 93: 101-8. PMID 25659771 DOI: 10.1016/j.ejmech.2015.02.001  0.64
2015 Feng Z, Pearce LV, Xu X, Yang X, Yang P, Blumberg PM, Xie XQ. Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations. Journal of Chemical Information and Modeling. 55: 572-88. PMID 25642729 DOI: 10.1021/ci5007189  0.64
2015 Ann J, Yoon S, Baek J, Kim da H, Lewin NE, Hill CS, Blumberg PM, Lee J. Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones). European Journal of Medicinal Chemistry. 90: 332-41. PMID 25437619 DOI: 10.1016/j.ejmech.2014.11.025  0.48
2014 Andrews IP, Ketcham JM, Blumberg PM, Kedei N, Lewin NE, Peach ML, Krische MJ. Synthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties. Journal of the American Chemical Society. 136: 13209-16. PMID 25207655 DOI: 10.1021/ja507825s  0.64
2014 Kraft MB, Poudel YB, Kedei N, Lewin NE, Peach ML, Blumberg PM, Keck GE. Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core. Journal of the American Chemical Society. 136: 13202-8. PMID 25207434 DOI: 10.1021/ja5078188  0.64
2014 Ryu H, Seo S, Kim MS, Kim MY, Kim HS, Ann J, Tran PT, Hoang VH, Byun J, Cui M, Son K, Sharma PK, Choi S, Blumberg PM, Frank-Foltyn R, et al. 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 4044-7. PMID 25011915 DOI: 10.1016/j.bmcl.2014.05.072  0.64
2014 Ryu H, Seo S, Cho SH, Kim HS, Jung A, Kang DW, Son K, Cui M, Hong SH, Sharma PK, Choi S, Blumberg PM, Frank-Foltyn R, Bahrenberg G, Stockhausen H, et al. 2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 4039-43. PMID 24948568 DOI: 10.1016/j.bmcl.2014.05.074  0.64
2014 Kedei N, Chen JQ, Herrmann MA, Telek A, Goldsmith PK, Petersen ME, Keck GE, Blumberg PM. Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands. Journal of Medicinal Chemistry. 57: 5356-69. PMID 24906106 DOI: 10.1021/jm500417b  0.64
2014 Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE, Santos M, Peach ML, Kelley JA, Blumberg PM, Jelinek R, et al. Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorganic & Medicinal Chemistry. 22: 3123-40. PMID 24794745 DOI: 10.1016/j.bmc.2014.04.024  0.48
2014 Kim HS, Jin MK, Kang SU, Lim JO, Tran PT, Hoang VH, Ann J, Ha TH, Pearce LV, Pavlyukovets VA, Blumberg PM, Lee J. α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters. 24: 2685-8. PMID 24794110 DOI: 10.1016/j.bmcl.2014.04.054  0.64
2014 Kelsey JS, Geczy T, Lewin NE, Kedei N, Hill CS, Selezneva JS, Valle CJ, Woo W, Gorshkova I, Blumberg PM. Charge density influences C1 domain ligand affinity and membrane interactions. Chembiochem : a European Journal of Chemical Biology. 15: 1131-44. PMID 24777910 DOI: 10.1002/cbic.201400041  0.48
2014 Pu Y, Kang JH, Sigano DM, Peach ML, Lewin NE, Marquez VE, Blumberg PM. Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains. Journal of Medicinal Chemistry. 57: 3835-44. PMID 24684293 DOI: 10.1021/jm500165n  0.48
2013 Ha TH, Ryu H, Kim SE, Kim HS, Ann J, Tran PT, Hoang VH, Son K, Cui M, Choi S, Blumberg PM, Frank R, Bahrenberg G, Schiene K, Christoph T, et al. TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides. Bioorganic & Medicinal Chemistry. 21: 6657-64. PMID 24035514 DOI: 10.1016/j.bmc.2013.08.015  0.64
2013 Song X, Lopez-Campistrous A, Sun L, Dower NA, Kedei N, Yang J, Kelsey JS, Lewin NE, Esch TE, Blumberg PM, Stone JC. RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. Plos One. 8: e72331. PMID 23991094 DOI: 10.1371/journal.pone.0072331  0.48
2013 Chen JQ, Heldman MR, Herrmann MA, Kedei N, Woo W, Blumberg PM, Goldsmith PK. Absolute quantitation of endogenous proteins with precision and accuracy using a capillary Western system. Analytical Biochemistry. 442: 97-103. PMID 23896461 DOI: 10.1016/j.ab.2013.07.022  0.64
2013 Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, et al. Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1. Acs Chemical Biology. 8: 767-77. PMID 23369356 DOI: 10.1021/cb300671s  0.64
2013 Rahman GM, Shanker S, Lewin NE, Kedei N, Hill CS, Prasad BV, Blumberg PM, Das J. Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ). The Biochemical Journal. 451: 33-44. PMID 23289588 DOI: 10.1042/BJ20121307  0.64
2013 Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 147-58. PMID 23209318 DOI: 10.4049/jimmunol.1201458  0.64
2012 Cho Y, Kim MS, Kim HS, Ann J, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Blumberg PM, Lee J. The SAR analysis of TRPV1 agonists with the α-methylated B-region. Bioorganic & Medicinal Chemistry Letters. 22: 5227-31. PMID 22796184 DOI: 10.1016/j.bmcl.2012.06.059  0.64
2012 Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity. Bioorganic & Medicinal Chemistry Letters. 22: 4084-8. PMID 22579485 DOI: 10.1016/j.bmcl.2012.04.073  0.64
2012 Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang JH, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM. Molecular basis for failure of "atypical" C1 domain of Vav1 to bind diacylglycerol/phorbol ester. The Journal of Biological Chemistry. 287: 13137-58. PMID 22351766 DOI: 10.1074/jbc.M111.320010  0.64
2012 Sun W, Liu K, Ryu H, Kang DW, Kim YS, Kim MS, Cho Y, Bhondwe RS, Thorat SA, Kim HS, Pearce LV, Pavlyukovets VA, Tran R, Morgan MA, Lazar J, ... ... Blumberg PM, et al. 2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions. Bioorganic & Medicinal Chemistry. 20: 1310-8. PMID 22227463 DOI: 10.1016/j.bmc.2011.12.014  0.64
2012 Kim YS, Kil MJ, Kang SU, Ryu H, Kim MS, Cho Y, Bhondwe RS, Thorat SA, Sun W, Liu K, Lee JH, Choi S, Pearce LV, Pavlyukovets VA, Morgan MA, ... ... Blumberg PM, et al. N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region. Bioorganic & Medicinal Chemistry. 20: 215-24. PMID 22169633 DOI: 10.1016/j.bmc.2011.11.008  0.64
2011 Gal N, Kolusheva S, Kedei N, Telek A, Naeem TA, Lewin NE, Lim L, Mannan P, Garfield SH, El Kazzouli S, Sigano DM, Marquez VE, Blumberg PM, Jelinek R. N-methyl-substituted fluorescent DAG-indololactone isomers exhibit dramatic differences in membrane interactions and biological activity. Chembiochem : a European Journal of Chemical Biology. 12: 2331-40. PMID 23106081 DOI: 10.1002/cbic.201100246  0.64
2011 Nomura W, Narumi T, Ohashi N, Serizawa Y, Lewin NE, Blumberg PM, Furuta T, Tamamura H. Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C. Chembiochem : a European Journal of Chemical Biology. 12: 535-9. PMID 22238145 DOI: 10.1002/cbic.201000670  0.64
2011 Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM. RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene. 30: 4590-600. PMID 21602881 DOI: 10.1038/onc.2011.166  0.48
2011 Kedei N, Lubart E, Lewin NE, Telek A, Lim L, Mannan P, Garfield SH, Kraft MB, Keck GE, Kolusheva S, Jelinek R, Blumberg PM. Some phorbol esters might partially resemble bryostatin 1 in their actions on LNCaP prostate cancer cells and U937 leukemia cells. Chembiochem : a European Journal of Chemical Biology. 12: 1242-51. PMID 21542090 DOI: 10.1002/cbic.201100064  0.64
2011 Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, ... Blumberg PM, et al. The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line. Biochemical Pharmacology. 81: 1296-308. PMID 21458422 DOI: 10.1016/j.bcp.2011.03.018  0.64
2011 Ohashi N, Nomura W, Narumi T, Lewin NE, Itotani K, Blumberg PM, Tamamura H. Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding. Bioconjugate Chemistry. 22: 82-7. PMID 21175182 DOI: 10.1021/bc100414a  0.64
2010 Yang D, Kedei N, Li L, Tao J, Velasquez JF, Michalowski AM, Tóth BI, Marincsák R, Varga A, Bíró T, Yuspa SH, Blumberg PM. RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype. Cancer Research. 70: 7905-17. PMID 20876802 DOI: 10.1158/0008-5472.CAN-09-4729  0.48
2010 Raifman O, Kolusheva S, El Kazzouli S, Sigano DM, Kedei N, Lewin NE, Lopez-Nicolas R, Ortiz-Espin A, Gomez-Fernandez JC, Blumberg PM, Marquez VE, Corbalan-Garcia S, Jelinek R. Membrane-surface anchoring of charged diacylglycerol-lactones correlates with biological activities. Chembiochem : a European Journal of Chemical Biology. 11: 2003-9. PMID 20715268 DOI: 10.1002/cbic.201000343  0.48
2010 Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Peach ML, Blumberg PM. Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1. Angewandte Chemie (International Ed. in English). 49: 4580-4. PMID 20491108 DOI: 10.1002/anie.201001200  0.64
2010 Kang JH, Kim Y, Won SH, Park SK, Lee CW, Kim HM, Lewin NE, Perry NA, Pearce LV, Lundberg DJ, Surawski RJ, Blumberg PM, Lee J. Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. Bioorganic & Medicinal Chemistry Letters. 20: 1008-12. PMID 20045644 DOI: 10.1016/j.bmcl.2009.12.058  0.64
2010 Raifman O, Kolusheva S, Comin MJ, Kedei N, Lewin NE, Blumberg PM, Marquez VE, Jelinek R. Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities. The Febs Journal. 277: 233-43. PMID 19961537 DOI: 10.1111/j.1742-4658.2009.07477.x  0.48
2009 Ohashi N, Nomura W, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H. Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. Journal of Peptide Science : An Official Publication of the European Peptide Society. 15: 642-6. PMID 19672879 DOI: 10.1002/psc.1161  0.64
2009 Sosa MS, Lewin NE, Choi SH, Blumberg PM, Kazanietz MG. Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains. Biochemistry. 48: 8171-8. PMID 19618918 DOI: 10.1021/bi9010623  0.48
2009 Keck GE, Li W, Kraft MB, Kedei N, Lewin NE, Blumberg PM. The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses. Organic Letters. 11: 2277-80. PMID 19419164 DOI: 10.1021/ol900585t  0.64
2009 Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers - PKC activation and HDAC inhibition - A dual drug approach to Alzheimer's disease that decreases Aβ production while blocking oxidative stress Chemmedchem. 4: 1095-1105. PMID 19396896 DOI: 10.1002/cmdc.200900045  0.64
2009 Comin MJ, Czifra G, Kedei N, Telek A, Lewin NE, Kolusheva S, Velasquez JF, Kobylarz R, Jelinek R, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths. Journal of Medicinal Chemistry. 52: 3274-83. PMID 19379015 DOI: 10.1021/jm900186m  0.48
2009 Choi HK, Choi S, Lee Y, Kang DW, Ryu H, Maeng HJ, Chung SJ, Pavlyukovets VA, Pearce LV, Toth A, Tran R, Wang Y, Morgan MA, Blumberg PM, Lee J. Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorganic & Medicinal Chemistry. 17: 690-8. PMID 19135377 DOI: 10.1016/j.bmc.2008.11.085  0.64
2009 Keck GE, Poudel YB, Welch DS, Kraft MB, Truong AP, Stephens JC, Kedei N, Lewin NE, Blumberg PM. Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters. Organic Letters. 11: 593-6. PMID 19113896 DOI: 10.1021/ol8027253  0.64
2009 Stang SL, Lopez-Campistrous A, Song X, Dower NA, Blumberg PM, Wender PA, Stone JC. A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. Experimental Hematology. 37: 122-134. PMID 19100522 DOI: 10.1016/j.exphem.2008.09.008  0.64
2009 Pu Y, Garfield SH, Kedei N, Blumberg PM. Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta. The Journal of Biological Chemistry. 284: 1302-12. PMID 19001377 DOI: 10.1074/jbc.M804796200  0.64
2009 Lim JO, Jin MK, Ryu H, Kang DW, Lee J, Pearce LV, Tran R, Toth A, Blumberg PM. Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists. European Journal of Medicinal Chemistry. 44: 322-31. PMID 18406014 DOI: 10.1016/j.ejmech.2008.02.026  0.64
2008 Philosof-Mazor L, Volinsky R, Comin MJ, Lewin NE, Kedei N, Blumberg PM, Marquez VE, Jelinek R. Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 11043-52. PMID 18788772 DOI: 10.1021/la802204n  0.48
2008 El Kazzouli S, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol. 30. An investigation of diacylglycerol-lactones containing heteroaryl groups reveals compounds with high selectivity for Ras guanyl nucleotide-releasing proteins. Journal of Medicinal Chemistry. 51: 5371-86. PMID 18707088 DOI: 10.1021/jm800380b  0.48
2008 Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, ... ... Blumberg PM, et al. Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities. Journal of Medicinal Chemistry. 51: 5198-220. PMID 18698758 DOI: 10.1021/jm8001907  0.64
2008 Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM. Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function. Journal of the American Chemical Society. 130: 6660-1. PMID 18452293 DOI: 10.1021/ja8022169  0.64
2008 Lomonaco SL, Kahana S, Blass M, Brody Y, Okhrimenko H, Xiang C, Finniss S, Blumberg PM, Lee HK, Brodie C. Phosphorylation of protein kinase Cδ on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: Role in the apoptotic effect of etoposide Journal of Biological Chemistry. 283: 17731-17739. PMID 18434324 DOI: 10.1074/jbc.M801727200  0.64
2008 Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM. Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. The Journal of Biological Chemistry. 283: 10543-9. PMID 18263588 DOI: 10.1074/jbc.M707463200  0.48
2008 Ryu H, Jin MK, Kim SY, Choi HK, Kang SU, Kang DW, Lee J, Pearce LV, Pavlyukovets VA, Morgan MA, Tran R, Toth A, Lundberg DJ, Blumberg PM. Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. Journal of Medicinal Chemistry. 51: 57-67. PMID 18072720 DOI: 10.1021/jm701049p  0.64
2008 Zhu H, Yang Y, Zhang H, Han Y, Li Y, Zhang Y, Yin D, He Q, Zhao Z, Blumberg PM, Han J, Wang Y. Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity. Pain. 137: 574-88. PMID 18063480 DOI: 10.1016/j.pain.2007.10.025  0.64
2007 Chung JU, Kim SY, Lim JO, Choi HK, Kang SU, Yoon HS, Ryu H, Kang DW, Lee J, Kang B, Choi S, Toth A, Pearce LV, Pavlyukovets VA, Lundberg DJ, ... Blumberg PM, et al. Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry. 15: 6043-53. PMID 17629487 DOI: 10.1016/j.bmc.2007.06.041  0.64
2007 Choi Y, Pu Y, Peach ML, Kang JH, Lewin NE, Sigano DM, Garfield SH, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta. Journal of Medicinal Chemistry. 50: 3465-81. PMID 17591763 DOI: 10.1021/jm0702579  0.64
2007 Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. The Journal of Pharmacology and Experimental Therapeutics. 321: 791-8. PMID 17312187 DOI: 10.1124/jpet.106.117572  0.64
2005 Okhrimenko H, Lu W, Xiang C, Ju D, Blumberg PM, Gomel R, Kazimirsky G, Brodie C. Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. The Journal of Biological Chemistry. 280: 23643-52. PMID 15774464 DOI: 10.1074/jbc.M501374200  0.8
2004 Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM. PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. Molecular Pharmacology. 66: 76-84. PMID 15213298 DOI: 10.1124/mol.66.1.76  0.64
2002 Zrachia A, Dobroslav M, Blass M, Kazimirsky G, Kronfeld I, Blumberg PM, Kobiler D, Lustig S, Brodie C. Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. The Journal of Biological Chemistry. 277: 23693-701. PMID 11927579 DOI: 10.1074/jbc.M111658200  0.64
2002 Blass M, Kronfeld I, Kazimirsky G, Blumberg PM, Brodie C. Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Molecular and Cellular Biology. 22: 182-95. PMID 11739733  0.8
Show low-probability matches.