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Robert Signer - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
 2009-2015 Children's Research Institute University of Texas Southwestern Medical Center at Dallas, Dallas, TX, United States 
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lam K, Kim YJ, Ong CM, Liu AZ, Zhou FJ, Sunshine MJ, Chua BA, Vicenzi S, Ford PW, Zhou JH, Hong Y, Bennett EJ, Crews LA, Ball ED, Signer RAJ. The Proteostasis Network is a Therapeutic Target in Acute Myeloid Leukemia. Biorxiv : the Preprint Server For Biology. PMID 39386464 DOI: 10.1101/2024.09.24.614781  0.409
2023 Chua BA, Lennan CJ, Sunshine MJ, Dreifke D, Chawla A, Bennett EJ, Signer RAJ. Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis. Cell Stem Cell. PMID 36948186 DOI: 10.1016/j.stem.2023.02.010  0.509
2021 Kruta M, Sunshine MJ, Chua BA, Fu Y, Chawla A, Dillingham CH, Hidalgo San Jose L, De Jong B, Zhou FJ, Signer RAJ. Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging. Cell Stem Cell. PMID 34388375 DOI: 10.1016/j.stem.2021.07.009  0.499
2021 Magee JA, Signer RAJ. Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis. Stem Cell Reports. 16: 20-28. PMID 33440178 DOI: 10.1016/j.stemcr.2020.11.017  0.707
2020 Lam K, Signer RAJ. ERADicating stem cells from their niche. Nature Cell Biology. PMID 32958855 DOI: 10.1038/s41556-020-00585-7  0.564
2020 Chua BA, Signer RAJ. Hematopoietic stem cell regulation by the proteostasis network. Current Opinion in Hematology. PMID 32452878 DOI: 10.1097/MOH.0000000000000591  0.432
2020 Chua BA, Van Der Werf I, Jamieson C, Signer RAJ. Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells. Cell Stem Cell. 26: 138-159. PMID 32032524 DOI: 10.1016/j.stem.2020.01.005  0.511
2020 Hidalgo San Jose L, Sunshine MJ, Dillingham CH, Chua BA, Kruta M, Hong Y, Hatters DM, Signer RAJ. Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. Cell Reports. 30: 69-80.e6. PMID 31914399 DOI: 10.1016/j.celrep.2019.12.003  0.548
2019 Hidalgo San Jose L, Signer RAJ. Cell-type-specific quantification of protein synthesis in vivo. Nature Protocols. PMID 30610239 DOI: 10.1038/s41596-018-0100-z  0.487
2019 Signer R. Proteostasis and Myeloid Stem Cell Production Blood. 134. DOI: 10.1182/Blood-2019-121085  0.566
2019 Signer R, Kruta M, Sunshine MJ, Fu Y, Jose LHS. 2002 - Ex Vivo Activation Of Heat Shock Factor 1 (Hsf1) Promotes Sustained Hematopoietic Stem Cell Self-Renewal Experimental Hematology. 76. DOI: 10.1016/J.Exphem.2019.06.277  0.524
2018 Kruta M, Signer RAJ. Living Up to the Hype: Protein Synthesis Promotes Hypertranscription in Embryonic Stem Cells. Cell Stem Cell. 22: 281-282. PMID 29499142 DOI: 10.1016/j.stem.2018.02.008  0.544
2018 Signer R, Dillingham C, Sunshine MJ, Jose LHS, Kruta M, Hong Y, Hatters D. Hematopoietic Stem Cells Require Elevated Protein Quality Control Experimental Hematology. 64. DOI: 10.1016/J.Exphem.2018.06.150  0.548
2017 Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J, Bixby D, Markowitz N, Morrison SJ, Collins KL. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. Plos Pathogens. 13: e1006509. PMID 28732051 DOI: 10.1371/journal.ppat.1006509  0.529
2017 Mgbemena VE, Signer RA, Wijayatunge R, Laxson T, Morrison SJ, Ross TS. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Reports. 18: 947-960. PMID 28122244 DOI: 10.1016/J.Celrep.2016.12.075  0.548
2016 Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, et al. Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function. Nature. PMID 27919080 DOI: 10.1038/Nature19831  0.479
2016 Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes & Development. PMID 27492367 DOI: 10.1101/Gad.282756.116  0.666
2016 Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. PMID 27185281 DOI: 10.1016/J.Stemcr.2016.04.008  0.685
2016 Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, et al. Lens regeneration using endogenous stem cells with gain of visual function. Nature. PMID 26958831 DOI: 10.1038/Nature17181  0.586
2016 Liu X, Zhang Y, Ni M, Cao H, Signer R, Li D, Gu Z, Hu Z, Chandel N, DeBerardinis R, Zhou F, Shao Z, Xu J. Mitochondria Coordinate Intracellular Metabolism and Epigenetic Gene Regulation during Erythropoiesis Blood. 128: 1038-1038. DOI: 10.1182/Blood.V128.22.1038.1038  0.425
2016 Signer R, Qi L, Zhao Z, Thompson D, Sigova A, Fan ZP, DeMartino G, Young R, Sonenberg N, Morrison S. The low rate of protein synthesis in hematopoietic stem cells is determined partly by hypophosphorylation of 4E-BPS Experimental Hematology. 44: S98. DOI: 10.1016/J.Exphem.2016.06.213  0.68
2015 Liu X, Zhang Y, Zhou F, Shao Z, Signer R, Cao H, Hu Z, DeBerardinis R, Xu J. Quantitative Proteomic and Transcriptomic Analysis Reveals Post-Transcriptional Regulation of Mitochondrial Biogenesis during Erythropoiesis Blood. 126: 47-47. DOI: 10.1182/Blood.V126.23.47.47  0.432
2014 Buszczak M, Signer RA, Morrison SJ. Cellular differences in protein synthesis regulate tissue homeostasis. Cell. 159: 242-51. PMID 25303523 DOI: 10.1016/J.Cell.2014.09.016  0.658
2014 Mich JK, Signer RA, Nakada D, Pineda A, Burgess RJ, Vue TY, Johnson JE, Morrison SJ. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife. 3: e02669. PMID 24843006 DOI: 10.7554/Elife.02669  0.637
2014 Signer RA, Magee JA, Salic A, Morrison SJ. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 509: 49-54. PMID 24670665 DOI: 10.1038/Nature13035  0.727
2013 Signer RA, Morrison SJ. Mechanisms that regulate stem cell aging and life span. Cell Stem Cell. 12: 152-65. PMID 23395443 DOI: 10.1016/j.stem.2013.01.001  0.608
2007 Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 110: 1831-9. PMID 17554060 DOI: 10.1182/Blood-2007-01-069401  0.332
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