Joel C. Watts - Publications

Affiliations: 
2003-2008 Centre for Research in Neurodegenerative Diseases University of Toronto, Toronto, ON, Canada 
 2008-2014 Institute for Neurodegenerative Diseases, Department of Neurology University of California, San Francisco, San Francisco, CA 
 2014- Tanz Centre for Research in Neurodegenerative Diseases, Department of Biochemistry University of Toronto, Toronto, ON, Canada 
Website:
http://biochemistry.utoronto.ca/person/joel-c-watts/

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bourkas MEC, Arshad H, Al-Azzawi ZAM, Halgas O, Shikiya RA, Mehrabian M, Schmitt-Ulms G, Bartz JC, Watts JC. Engineering a murine cell line for the stable propagation of hamster prions. The Journal of Biological Chemistry. PMID 30705093 DOI: 10.1074/jbc.RA118.007135  1
2018 Ghodrati F, Mehrabian M, Williams D, Halgas O, Bourkas MEC, Watts JC, Pai EF, Schmitt-Ulms G. The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling. Scientific Reports. 8: 8654. PMID 29872131 DOI: 10.1038/s41598-018-26685-x  1
2018 Lau HHC, Lau A, Watts JC. Discriminating Strains of Self-Propagating Protein Aggregates Using a Conformational Stability Assay. Methods in Molecular Biology (Clifton, N.J.). 1777: 339-354. PMID 29744847 DOI: 10.1007/978-1-4939-7811-3_22  1
2018 Ruiz-Riquelme A, Lau HHC, Stuart E, Goczi AN, Wang Z, Schmitt-Ulms G, Watts JC. Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression. Acta Neuropathologica Communications. 6: 26. PMID 29615128 DOI: 10.1186/s40478-018-0529-x  1
2018 Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, et al. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311311 DOI: 10.1073/pnas.1714966115  1
2018 Watts JC, Bourkas MEC, Arshad H. The function of the cellular prion protein in health and disease. Acta Neuropathologica. 135: 159-178. PMID 29151170 DOI: 10.1007/s00401-017-1790-y  0.96
2017 Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G. Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers. Elife. 6. PMID 28650319 DOI: 10.7554/eLife.28401  1
2017 Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB. α-Synuclein: Multiple System Atrophy Prions. Cold Spring Harbor Perspectives in Medicine. PMID 28213437 DOI: 10.1101/cshperspect.a024588  1
2017 Watts JC, Prusiner SB. β-Amyloid Prions and the Pathobiology of Alzheimer's Disease. Cold Spring Harbor Perspectives in Medicine. PMID 28193770 DOI: 10.1101/cshperspect.a023507  1
2017 Watts JC, Prusiner SB. Experimental Models of Inherited PrP Prion Diseases. Cold Spring Harbor Perspectives in Medicine. PMID 28096244 DOI: 10.1101/cshperspect.a027151  1
2016 Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB. Guinea pig prion protein supports rapid propagation of bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease prions. Journal of Virology. PMID 27440899 DOI: 10.1128/JVI.01106-16  1
2016 Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB. Towards authentic transgenic mouse models of heritable PrP prion diseases. Acta Neuropathologica. PMID 27350609 DOI: 10.1007/s00401-016-1585-6  1
2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 112: E5308-17. PMID 26324905 DOI: 10.1073/pnas.1514475112  1
2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, et al. Propagation of prions causing synucleinopathies in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E4949-58. PMID 26286986 DOI: 10.1073/pnas.1513426112  1
2015 Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB. Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation. Annals of Neurology. 78: 540-53. PMID 26094969 DOI: 10.1002/ana.24463  1
2015 Wan W, Wille H, Stöhr J, Kendall A, Bian W, McDonald M, Tiggelaar S, Watts JC, Prusiner SB, Stubbs G. Structural studies of truncated forms of the prion protein PrP. Biophysical Journal. 108: 1548-54. PMID 25809267 DOI: 10.1016/j.bpj.2015.01.008  1
2014 Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 111: 10323-8. PMID 24982139 DOI: 10.1073/pnas.1408900111  1
2014 Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10329-34. PMID 24982137 DOI: 10.1073/pnas.1408968111  1
2014 Watts JC, Prusiner SB. Mouse models for studying the formation and propagation of prions. The Journal of Biological Chemistry. 289: 19841-9. PMID 24860095 DOI: 10.1074/jbc.R114.550707  1
2014 Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB. Evidence that bank vole PrP is a universal acceptor for prions. Plos Pathogens. 10: e1003990. PMID 24699458 DOI: 10.1371/journal.ppat.1003990  1
2014 Mays CE, Coomaraswamy J, Watts JC, Yang J, Ko KW, Strome B, Mercer RC, Wohlgemuth SL, Schmitt-Ulms G, Westaway D. Endoproteolytic processing of the mammalian prion glycoprotein family. The Febs Journal. 281: 862-76. PMID 24286250 DOI: 10.1111/febs.12654  1
2013 Mercer RC, Ma L, Watts JC, Strome R, Wohlgemuth S, Yang J, Cashman NR, Coulthart MB, Schmitt-Ulms G, Jhamandas JH, Westaway D. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. The Journal of Biological Chemistry. 288: 37241-55. PMID 24225951 DOI: 10.1074/jbc.M113.488650  1
2013 Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Transmission of multiple system atrophy prions to transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 19555-60. PMID 24218576 DOI: 10.1073/pnas.1318268110  1
2013 Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Drug resistance confounding prion therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 110: E4160-9. PMID 24128760 DOI: 10.1073/pnas.1317164110  1
2012 Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K. Purified and synthetic Alzheimer's amyloid beta (Aβ) prions. Proceedings of the National Academy of Sciences of the United States of America. 109: 11025-30. PMID 22711819 DOI: 10.1073/pnas.1206555109  1
2012 Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB. Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein. Proceedings of the National Academy of Sciences of the United States of America. 109: 3498-503. PMID 22331873 DOI: 10.1073/pnas.1121556109  1
2011 Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB. Protease-resistant prions selectively decrease Shadoo protein. Plos Pathogens. 7: e1002382. PMID 22163178 DOI: 10.1371/journal.ppat.1002382  1
2011 Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K. Spontaneous generation of anchorless prions in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 21223-8. PMID 22160704 DOI: 10.1073/pnas.1117827108  1
2011 Ghaemmaghami S, Watts JC, Nguyen HO, Hayashi S, DeArmond SJ, Prusiner SB. Conformational transformation and selection of synthetic prion strains. Journal of Molecular Biology. 413: 527-42. PMID 21839745 DOI: 10.1016/j.jmb.2011.07.021  1
2011 Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 2528-33. PMID 21262831 DOI: 10.1073/pnas.1019034108  1
2011 Ehsani S, Huo H, Salehzadeh A, Pocanschi CL, Watts JC, Wille H, Westaway D, Rogaeva E, St George-Hyslop PH, Schmitt-Ulms G. Family reunion--the ZIP/prion gene family. Progress in Neurobiology. 93: 405-20. PMID 21163327 DOI: 10.1016/j.pneurobio.2010.12.001  1
2010 Daude N, Ng V, Watts JC, Genovesi S, Glaves JP, Wohlgemuth S, Schmitt-Ulms G, Young H, McLaurin J, Fraser PE, Westaway D. Wild-type Shadoo proteins convert to amyloid-like forms under native conditions. Journal of Neurochemistry. 113: 92-104. PMID 20067571 DOI: 10.1111/j.1471-4159.2010.06575.x  1
2009 Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Won AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. Plos Pathogens. 5: e1000608. PMID 19798432 DOI: 10.1371/journal.ppat.1000608  1
2009 Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. Evolutionary descent of prion genes from the ZIP family of metal ion transporters. Plos One. 4: e7208. PMID 19784368 DOI: 10.1371/journal.pone.0007208  1
2008 Bi Y, Watts JC, Bamford PK, Briere LK, Dunn SD. Probing the functional tolerance of the b subunit of Escherichia coli ATP synthase for sequence manipulation through a chimera approach. Biochimica Et Biophysica Acta. 1777: 583-91. PMID 18395001 DOI: 10.1016/j.bbabio.2008.03.004  1
2007 Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, et al. The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections. The Embo Journal. 26: 4038-50. PMID 17703189 DOI: 10.1038/sj.emboj.7601830  1
2006 Watts JC, Balachandran A, Westaway D. The expanding universe of prion diseases Plos Pathogens. 2. PMID 16609731 DOI: 10.1371/journal.ppat.0020026  1
2004 Drisaldi B, Coomaraswamy J, Mastrangelo P, Strome B, Yang J, Watts JC, Chishti MA, Marvi M, Windl O, Ahrens R, Major F, Sy MS, Kretzschmar H, Fraser PE, Mount HT, et al. Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region. The Journal of Biological Chemistry. 279: 55443-54. PMID 15459186 DOI: 10.1074/jbc.M404794200  1
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