Nicholas M Kanaan - Publications

Michigan State University, East Lansing, MI 
Alzheimer's Disease, dementia, tauoapthies, tau protein, cytoskeleton, transport, neurodegeneration

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Patterson JR, Duffy MF, Kemp CJ, Howe JW, Collier TJ, Stoll AC, Miller KM, Patel P, Levine N, Moore DJ, Luk KC, Fleming SM, Kanaan NM, Paumier KL, El-Agnaf OMA, et al. Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiology of Disease. 104525. PMID 31276792 DOI: 10.1016/j.nbd.2019.104525  0.84
2019 Patterson JR, Polinski NK, Duffy MF, Kemp CJ, Luk KC, Volpicelli-Daley LA, Kanaan NM, Sortwell CE. Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo. Journal of Visualized Experiments : Jove. PMID 31205308 DOI: 10.3791/59758  0.64
2019 Christensen KR, Beach TG, Serrano GE, Kanaan NM. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta Neuropathologica Communications. 7: 29. PMID 30819250 DOI: 10.1186/s40478-019-0675-9  0.32
2018 Tiernan CT, Ginsberg SD, He B, Ward SM, Guillozet-Bongaarts AL, Kanaan NM, Mufson EJ, Counts SE. Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiology of Disease. PMID 29859871 DOI: 10.1016/j.nbd.2018.05.021  0.64
2018 Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer DL, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, et al. Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of Neuroinflammation. 15: 169. PMID 29843738 DOI: 10.1186/s12974-018-1202-9  0.84
2018 Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer LD, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, et al. Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of Neuroinflammation. 15: 129. PMID 29716614 DOI: 10.1186/s12974-018-1171-z  0.84
2018 Tiernan CT, Mufson EJ, Kanaan NM, Counts SE. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. PMID 29378005 DOI: 10.1093/jnen/nlx120  0.64
2017 Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan NM. Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms. Frontiers in Neuroscience. 11: 572. PMID 29089864 DOI: 10.3389/fnins.2017.00572  1
2017 Kanaan NM, Sellnow RC, Boye SL, Coberly B, Bennett A, Agbandje-McKenna M, Sortwell CE, Hauswirth WW, Boye SE, Manfredsson FP. Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS. Molecular Therapy. Nucleic Acids. 8: 184-197. PMID 28918020 DOI: 10.1016/j.omtn.2017.06.011  0.84
2017 Combs B, Tiernan CT, Hamel C, Kanaan NM. Production of recombinant tau oligomers in vitro. Methods in Cell Biology. 141: 45-64. PMID 28882311 DOI: 10.1016/bs.mcb.2017.06.005  0.64
2017 Kneynsberg A, Kanaan NM. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. Eneuro. 4. PMID 28785724 DOI: 10.1523/ENEURO.0043-17.2017  1
2017 Collier TJ, Kanaan NM, Kordower JH. Aging and Parkinson's disease: Different sides of the same coin? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28520211 DOI: 10.1002/mds.27037  0.84
2017 Combs B, Kanaan NM. Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies. The American Journal of Pathology. 187: 1222-1229. PMID 28413156 DOI: 10.1016/j.ajpath.2017.01.019  0.64
2016 Grabinski T, Kanaan NM. Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation. Frontiers in Molecular Neuroscience. 9: 123. PMID 27909397 DOI: 10.3389/fnmol.2016.00123  0.64
2016 Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Injury. 30: 1399-1413. PMID 27834536 DOI: 10.1080/02699052.2016.1219058  0.64
2016 Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, et al. Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific Reports. 6: 34904. PMID 27721502 DOI: 10.1038/srep34904  0.44
2016 Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM. Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiology of Aging. 47: 113-126. PMID 27574109 DOI: 10.1016/j.neurobiolaging.2016.07.015  0.92
2016 Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental Neurology. PMID 27373205 DOI: 10.1016/j.expneurol.2016.06.030  0.92
2016 Combs B, Hamel C, Kanaan NM. Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies. Neurobiology of Disease. PMID 27260838 DOI: 10.1016/j.nbd.2016.05.016  0.92
2016 Tiernan CT, Ginsberg SD, Guillozet-Bongaarts AL, Ward SM, He B, Kanaan NM, Mufson EJ, Binder LI, Counts SE. Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiology of Aging. 42: 80-90. PMID 27143424 DOI: 10.1016/j.neurobiolaging.2016.02.031  0.92
2016 Kneynsberg A, Collier TJ, Manfredsson FP, Kanaan NM. Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures. Journal of Neuroscience Methods. 266: 32-41. PMID 27031947 DOI: 10.1016/j.jneumeth.2016.03.004  1
2016 Combs B, Kneynsberg A, Kanaan NM. Gene Therapy Models of Alzheimer's Disease and Other Dementias. Methods in Molecular Biology (Clifton, N.J.). 1382: 339-66. PMID 26611599 DOI: 10.1007/978-1-4939-3271-9_25  1
2015 Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. Journal of Neuropathology and Experimental Neurology. PMID 26671985 DOI: 10.1093/jnen/nlv001  0.64
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/j.nbd.2015.06.003  0.92
2015 Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW. The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. Plos One. 10: e0127768. PMID 25992874 DOI: 10.1371/journal.pone.0127768  0.92
2015 Grabinski TM, Kneynsberg A, Manfredsson FP, Kanaan NM. A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. Plos One. 10: e0120120. PMID 25794171 DOI: 10.1371/journal.pone.0120120  0.92
2015 Polinski NK, Gombash SE, Manfredsson FP, Lipton JW, Kemp CJ, Cole-Strauss A, Kanaan NM, Steece-Collier K, Kuhn NC, Wohlgenant SL, Sortwell CE. Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of Aging. 36: 1110-20. PMID 25457558 DOI: 10.1016/j.neurobiolaging.2014.07.047  0.92
2013 Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA. Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental Neurology. 246: 44-53. PMID 22721767 DOI: 10.1016/j.expneurol.2012.06.003  0.92
2012 Kanaan NM, Manfredsson FP. Loss of functional alpha-synuclein: a toxic event in Parkinson's disease? Journal of Parkinson's Disease. 2: 249-67. PMID 23938255 DOI: 10.3233/JPD-012138  0.92
2012 Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of Aging. 33: 826.e15-30. PMID 21794954 DOI: 10.1016/j.neurobiolaging.2011.06.006  0.92
2011 Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. 50: 10300-10. PMID 22039833 DOI: 10.1021/bi2009147  0.92
2011 Vana L, Kanaan NM, Ugwu IC, Wuu J, Mufson EJ, Binder LI. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American Journal of Pathology. 179: 2533-50. PMID 21945902 DOI: 10.1016/j.ajpath.2011.07.044  0.92
2011 Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9858-68. PMID 21734277 DOI: 10.1523/JNEUROSCI.0560-11.2011  0.92
2011 Collier TJ, Kanaan NM, Kordower JH. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nature Reviews. Neuroscience. 12: 359-66. PMID 21587290 DOI: 10.1038/nrn3039  0.92
2011 Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, Ward S, Reyes JF, Philibert K, Glucksman MJ, Binder LI. Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. The Journal of Biological Chemistry. 286: 23063-76. PMID 21550980 DOI: 10.1074/jbc.M111.237974  0.92
2011 Reyes JF, Fu Y, Vana L, Kanaan NM, Binder LI. Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease. The American Journal of Pathology. 178: 2275-85. PMID 21514440 DOI: 10.1016/j.ajpath.2011.01.030  0.92
2011 Vana L, Kanaan NM, Hakala K, Weintraub ST, Binder LI. Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation. Biochemistry. 50: 1203-12. PMID 21210655 DOI: 10.1021/bi101735m  0.92
2010 Kanaan NM, Kordower JH, Collier TJ. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiology of Aging. 31: 937-52. PMID 18715678 DOI: 10.1016/j.neurobiolaging.2008.07.006  0.92
2009 Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/JNEUROSCI.3463-09.2009  0.92
2008 Kanaan NM, Kordower JH, Collier TJ. Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. Glia. 56: 1199-214. PMID 18484101 DOI: 10.1002/glia.20690  0.92
2007 Kanaan NM, Kordower JH, Collier TJ. Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability. The Journal of Comparative Neurology. 502: 683-700. PMID 17436290 DOI: 10.1002/cne.21333  0.92
2006 Campbell NG, Koprich JB, Kanaan NM, Lipton JW. MDMA administration to pregnant Sprague-Dawley rats results in its passage to the fetal compartment. Neurotoxicology and Teratology. 28: 459-65. PMID 16905291 DOI: 10.1016/  0.92
2006 Kordower JH, Kanaan NM, Chu Y, Suresh Babu R, Stansell J, Terpstra BT, Sortwell CE, Steece-Collier K, Collier TJ. Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys. Annals of Neurology. 60: 264-8. PMID 16862579 DOI: 10.1002/ana.20935  0.92
2006 Kanaan NM, Collier TJ, Marchionini DM, McGuire SO, Fleming MF, Sortwell CE. Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease. Brain Research. 1068: 221-9. PMID 16368081 DOI: 10.1016/j.brainres.2005.10.078  0.92
2003 Koprich JB, Chen EY, Kanaan NM, Campbell NG, Kordower JH, Lipton JW. Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase fiber density of juvenile rats. Neurotoxicology and Teratology. 25: 509-17. PMID 12972064 DOI: 10.1016/S0892-0362(03)00091-6  0.92
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