| Year |
Citation |
Score |
| 2024 |
Yamaguchi T, Hamano T, Sada K, Asano R, Kanaan NM, Sasaki H, Yen SH, Kitazaki Y, Endo Y, Enomoto S, Shirafuji N, Ikawa M, Yamamura O, Fujita Y, Aoki K, et al. Syk inhibitors reduce tau protein phosphorylation and oligomerization. Neurobiology of Disease. 106656. PMID 39233131 DOI: 10.1016/j.nbd.2024.106656 |
0.375 |
|
| 2024 |
Beckman D, Diniz GB, Ott S, Hobson B, Chaudhari AJ, Muller S, Chu Y, Takano A, Schwarz AJ, Yeh CL, McQuade P, Chakrabarty P, Kanaan NM, Quinton MS, Simen AA, et al. Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 39030748 DOI: 10.1002/alz.13868 |
0.361 |
|
| 2024 |
Alhadidy MM, Kanaan NM. Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein. Biochemical Society Transactions. 52: 301-318. PMID 38348781 DOI: 10.1042/BST20230596 |
0.423 |
|
| 2023 |
Mueller RL, Kanaan NM, Combs B. Using Live-Cell Imaging to Measure the Effects of Pathological Proteins on Axonal Transport in Primary Hippocampal Neurons. Journal of Visualized Experiments : Jove. PMID 38189521 DOI: 10.3791/66156 |
0.796 |
|
| 2023 |
Kanaan NM. Tau here, tau there, tau almost everywhere: Clarifying the distribution of tau in the adult CNS. Cytoskeleton (Hoboken, N.J.). PMID 38102924 DOI: 10.1002/cm.21820 |
0.526 |
|
| 2023 |
Benskey MJ, Panoushek S, Saito T, Saido TC, Grabinski T, Kanaan NM. Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse. Frontiers in Aging Neuroscience. 15: 1265151. PMID 37842124 DOI: 10.3389/fnagi.2023.1265151 |
0.355 |
|
| 2023 |
Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D, Kanaan NM, Gan L, Condello C, Swaney DL, Kampmann M. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Biorxiv : the Preprint Server For Biology. PMID 37398204 DOI: 10.1101/2023.06.16.545386 |
0.481 |
|
| 2023 |
Christensen KR, Combs B, Richards C, Grabinski T, Alhadidy MM, Kanaan NM. Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons. Molecular Neurobiology. PMID 36859689 DOI: 10.1007/s12035-023-03281-3 |
0.85 |
|
| 2022 |
Ono M, Komatsu M, Ji B, Takado Y, Shimojo M, Minamihisamatsu T, Warabi E, Yanagawa T, Matsumoto G, Aoki I, Kanaan NM, Suhara T, Sahara N, Higuchi M. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging Cell. e13615. PMID 35662390 DOI: 10.1111/acel.13615 |
0.381 |
|
| 2021 |
Lin G, Zhu F, Kanaan NM, Asano R, Shirafuji N, Sasaki H, Yamaguchi T, Enomoto S, Endo Y, Ueno A, Ikawa M, Hayashi K, Yamamura O, Yen SH, Nakamoto Y, et al. Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein. International Journal of Molecular Sciences. 22. PMID 34769495 DOI: 10.3390/ijms222112063 |
0.412 |
|
| 2021 |
Combs B, Christensen KR, Richards C, Kneynsberg A, Mueller RL, Morris SL, Morfini G, Brady ST, Kanaan NM. FTLD mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34607969 DOI: 10.1523/JNEUROSCI.1914-20.2021 |
0.835 |
|
| 2021 |
Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, ... ... Kanaan N, et al. Interaction of tau with HNRNPA2B1 and N-methyladenosine RNA mediates the progression of tauopathy. Molecular Cell. PMID 34453888 DOI: 10.1016/j.molcel.2021.07.038 |
0.365 |
|
| 2021 |
Kanaan NM, Grabinski T. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in Molecular Neuroscience. 14: 607303. PMID 33986642 DOI: 10.3389/fnmol.2021.607303 |
0.514 |
|
| 2021 |
Mueller RL, Combs B, Alhadidy MM, Brady ST, Morfini GA, Kanaan NM. Tau: A Signaling Hub Protein. Frontiers in Molecular Neuroscience. 14: 647054. PMID 33815057 DOI: 10.3389/fnmol.2021.647054 |
0.842 |
|
| 2021 |
Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, ... Kanaan NM, et al. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33619090 DOI: 10.1073/pnas.2014188118 |
0.399 |
|
| 2020 |
Puzzo D, Argyrousi EK, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, Acquarone E, Fà M, Li Puma DD, Grassi C, D'Adamio L, Kanaan NM, Fraser PE, Arancio O. Tau is not necessary for amyloid-beta-induced synaptic and memory impairments. The Journal of Clinical Investigation. PMID 32544084 DOI: 10.1172/Jci137040 |
0.473 |
|
| 2020 |
Kanaan NM, Hamel C, Grabinski T, Combs B. Liquid-liquid phase separation induces pathogenic tau conformations in vitro. Nature Communications. 11: 2809. PMID 32499559 DOI: 10.1038/S41467-020-16580-3 |
0.786 |
|
| 2020 |
Caneus J, Akanda N, Rumsey JW, Guo X, Jackson M, Long CJ, Sommerhage F, Georgieva S, Kanaan NM, Morgan D, Hickman JJ. A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ and tau-induced pathophysiological effects on long-term potentiation. Alzheimer's & Dementia (New York, N. Y.). 6: e12029. PMID 32490141 DOI: 10.1002/Trc2.12029 |
0.415 |
|
| 2019 |
Combs B, Mueller RL, Morfini G, Brady ST, Kanaan NM. Tau and Axonal Transport Misregulation in Tauopathies. Advances in Experimental Medicine and Biology. 1184: 81-95. PMID 32096030 DOI: 10.1007/978-981-32-9358-8_7 |
0.834 |
|
| 2019 |
Hamano T, Shirafuji N, Yen SH, Yoshida H, Kanaan NM, Hayashi K, Ikawa M, Yamamura O, Fujita Y, Kuriyama M, Nakamoto Y. Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of Aging. PMID 31982202 DOI: 10.1016/J.Neurobiolaging.2019.12.009 |
0.501 |
|
| 2019 |
Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, et al. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science Translational Medicine. 11. PMID 31852801 DOI: 10.1126/Scitranslmed.Aao6545 |
0.521 |
|
| 2019 |
Vega IE, Umstead A, Kanaan NM. EFhd2 Affects Tau Liquid-Liquid Phase Separation. Frontiers in Neuroscience. 13: 845. PMID 31456657 DOI: 10.3389/Fnins.2019.00845 |
0.448 |
|
| 2019 |
Patterson JR, Duffy MF, Kemp CJ, Howe JW, Collier TJ, Stoll AC, Miller KM, Patel P, Levine N, Moore DJ, Luk KC, Fleming SM, Kanaan NM, Paumier KL, El-Agnaf OMA, et al. Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiology of Disease. 104525. PMID 31276792 DOI: 10.1016/J.Nbd.2019.104525 |
0.796 |
|
| 2019 |
Patterson JR, Polinski NK, Duffy MF, Kemp CJ, Luk KC, Volpicelli-Daley LA, Kanaan NM, Sortwell CE. Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo. Journal of Visualized Experiments : Jove. PMID 31205308 DOI: 10.3791/59758 |
0.653 |
|
| 2019 |
Christensen KR, Beach TG, Serrano GE, Kanaan NM. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta Neuropathologica Communications. 7: 29. PMID 30819250 DOI: 10.1186/S40478-019-0675-9 |
0.833 |
|
| 2019 |
Kneynsberg A, Vega I, Kanaan NM. TRIM46 KNOCKDOWN CAUSES NEURONAL TAU REDISTRIBUTION AND INCREASES AXOSOMATIC TAU DIFFUSION Alzheimer's & Dementia. 15: P1622. DOI: 10.1016/J.Jalz.2019.06.4852 |
0.82 |
|
| 2019 |
Gordon MN, Beck JS, Kanaan NM, Winn ME, Ginsberg SD, Counts SE. P3-173: MICROARRAY ANALYSES REVEAL SENESCENCE-ASSOCIATED GENE EXPRESSION IN ALZHEIMER'S DISEASE AND TRANSGENIC MOUSE MODELS WITH AMYLOID DEPOSITION OR TAUOPATHY Alzheimer's & Dementia. 15: P996-P997. DOI: 10.1016/J.Jalz.2019.06.3202 |
0.4 |
|
| 2018 |
Tiernan CT, Ginsberg SD, He B, Ward SM, Guillozet-Bongaarts AL, Kanaan NM, Mufson EJ, Counts SE. Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease. Neurobiology of Disease. PMID 29859871 DOI: 10.1016/J.Nbd.2018.05.021 |
0.818 |
|
| 2018 |
Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer DL, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, et al. Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of Neuroinflammation. 15: 169. PMID 29843738 DOI: 10.1186/S12974-018-1202-9 |
0.761 |
|
| 2018 |
Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, et al. Tau Kinetics in Neurons and the Human Central Nervous System. Neuron. 98: 861-864. PMID 29772204 DOI: 10.1016/J.Neuron.2018.04.035 |
0.444 |
|
| 2018 |
Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer LD, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, et al. Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of Neuroinflammation. 15: 129. PMID 29716614 DOI: 10.1186/S12974-018-1171-Z |
0.776 |
|
| 2018 |
Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, et al. Tau Kinetics in Neurons and the Human Central Nervous System. Neuron. 97: 1284-1298.e7. PMID 29566794 DOI: 10.1016/J.Neuron.2018.02.015 |
0.528 |
|
| 2018 |
Shirafuji N, Hamano T, Yen SH, Kanaan NM, Yoshida H, Hayashi K, Ikawa M, Yamamura O, Kuriyama M, Nakamoto Y. Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization. International Journal of Molecular Sciences. 19. PMID 29562600 DOI: 10.3390/Ijms19030891 |
0.547 |
|
| 2018 |
Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29516269 DOI: 10.1007/S11481-018-9781-X |
0.474 |
|
| 2018 |
Tiernan CT, Mufson EJ, Kanaan NM, Counts SE. Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. PMID 29378005 DOI: 10.1093/Jnen/Nlx120 |
0.84 |
|
| 2018 |
Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, ... ... Kanaan NM, et al. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature Neuroscience. 21: 72-80. PMID 29273772 DOI: 10.1038/S41593-017-0022-Z |
0.503 |
|
| 2017 |
Kneynsberg A, Combs B, Christensen K, Morfini G, Kanaan NM. Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms. Frontiers in Neuroscience. 11: 572. PMID 29089864 DOI: 10.3389/Fnins.2017.00572 |
0.828 |
|
| 2017 |
Kanaan NM, Sellnow RC, Boye SL, Coberly B, Bennett A, Agbandje-McKenna M, Sortwell CE, Hauswirth WW, Boye SE, Manfredsson FP. Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS. Molecular Therapy. Nucleic Acids. 8: 184-197. PMID 28918020 DOI: 10.1016/J.Omtn.2017.06.011 |
0.624 |
|
| 2017 |
Combs B, Tiernan CT, Hamel C, Kanaan NM. Production of recombinant tau oligomers in vitro. Methods in Cell Biology. 141: 45-64. PMID 28882311 DOI: 10.1016/Bs.Mcb.2017.06.005 |
0.827 |
|
| 2017 |
Kneynsberg A, Kanaan NM. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. Eneuro. 4. PMID 28785724 DOI: 10.1523/ENEURO.0043-17.2017 |
0.843 |
|
| 2017 |
Collier TJ, Kanaan NM, Kordower JH. Aging and Parkinson's disease: Different sides of the same coin? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28520211 DOI: 10.1002/Mds.27037 |
0.573 |
|
| 2017 |
Combs B, Kanaan NM. Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies. The American Journal of Pathology. 187: 1222-1229. PMID 28413156 DOI: 10.1016/J.Ajpath.2017.01.019 |
0.831 |
|
| 2017 |
Wolozin B, Apicco DJ, Zhang C, Ash PEA, Maziuk B, Abdullatif AA, Ballance H, Goldberg LR, Yazdani N, Ung C, Kanaan NM, Ikezu T, Bryant CD, Li H. Tau-Induced Neurodegeneration Is Mediated By Rna Binding Proteins Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.157 |
0.344 |
|
| 2017 |
Kneynsberg A, Kanaan NM. [P4-090]: THE SUBCELLULAR LOCALIZATION OF TAU AND THE PROPERTIES OF MUTANT P301L TAU IN PRIMARY NEURON CULTURES Alzheimer's & Dementia. 13: P1293-P1293. DOI: 10.1016/J.Jalz.2017.06.1955 |
0.812 |
|
| 2016 |
Grabinski T, Kanaan NM. Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation. Frontiers in Molecular Neuroscience. 9: 123. PMID 27909397 DOI: 10.3389/Fnmol.2016.00123 |
0.368 |
|
| 2016 |
Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Injury. 30: 1399-1413. PMID 27834536 DOI: 10.1080/02699052.2016.1219058 |
0.375 |
|
| 2016 |
Koss DJ, Jones G, Cranston A, Gardner H, Kanaan NM, Platt B. Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline. Acta Neuropathologica. PMID 27770234 DOI: 10.1007/S00401-016-1632-3 |
0.509 |
|
| 2016 |
Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, et al. Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific Reports. 6: 34904. PMID 27721502 DOI: 10.1038/Srep34904 |
0.493 |
|
| 2016 |
Cox K, Combs B, Abdelmesih B, Morfini G, Brady ST, Kanaan NM. Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition. Neurobiology of Aging. 47: 113-126. PMID 27574109 DOI: 10.1016/J.Neurobiolaging.2016.07.015 |
0.843 |
|
| 2016 |
Hamano T, Shirafuji N, Makino C, Yen SH, Kanaan NM, Ueno A, Suzuki J, Ikawa M, Matsunaga A, Yamamura O, Kuriyama M, Nakamoto Y. Pioglitazone prevents tau oligomerization. Biochemical and Biophysical Research Communications. PMID 27543203 DOI: 10.1016/J.Bbrc.2016.08.016 |
0.541 |
|
| 2016 |
Tiernan CT, Combs B, Cox K, Morfini G, Brady ST, Counts SE, Kanaan NM. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Experimental Neurology. PMID 27373205 DOI: 10.1016/J.Expneurol.2016.06.030 |
0.838 |
|
| 2016 |
Combs B, Hamel C, Kanaan NM. Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies. Neurobiology of Disease. PMID 27260838 DOI: 10.1016/J.Nbd.2016.05.016 |
0.817 |
|
| 2016 |
Tiernan CT, Ginsberg SD, Guillozet-Bongaarts AL, Ward SM, He B, Kanaan NM, Mufson EJ, Binder LI, Counts SE. Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiology of Aging. 42: 80-90. PMID 27143424 DOI: 10.1016/J.Neurobiolaging.2016.02.031 |
0.833 |
|
| 2016 |
Kneynsberg A, Collier TJ, Manfredsson FP, Kanaan NM. Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures. Journal of Neuroscience Methods. 266: 32-41. PMID 27031947 DOI: 10.1016/J.Jneumeth.2016.03.004 |
0.814 |
|
| 2016 |
Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, ... ... Kanaan NM, et al. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Scientific Reports. 6: 19393. PMID 26786552 DOI: 10.1038/Srep19393 |
0.465 |
|
| 2016 |
Combs B, Kneynsberg A, Kanaan NM. Gene Therapy Models of Alzheimer's Disease and Other Dementias. Methods in Molecular Biology (Clifton, N.J.). 1382: 339-66. PMID 26611599 DOI: 10.1007/978-1-4939-3271-9_25 |
0.811 |
|
| 2015 |
Kanaan NM, Cox K, Alvarez VE, Stein TD, Poncil S, McKee AC. Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy. Journal of Neuropathology and Experimental Neurology. PMID 26671985 DOI: 10.1093/Jnen/Nlv001 |
0.549 |
|
| 2015 |
Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/J.Nbd.2015.06.003 |
0.792 |
|
| 2015 |
Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW. The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. Plos One. 10: e0127768. PMID 25992874 DOI: 10.1371/Journal.Pone.0127768 |
0.72 |
|
| 2015 |
Grabinski TM, Kneynsberg A, Manfredsson FP, Kanaan NM. A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. Plos One. 10: e0120120. PMID 25794171 DOI: 10.1371/Journal.Pone.0120120 |
0.775 |
|
| 2015 |
Polinski NK, Gombash SE, Manfredsson FP, Lipton JW, Kemp CJ, Cole-Strauss A, Kanaan NM, Steece-Collier K, Kuhn NC, Wohlgenant SL, Sortwell CE. Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of Aging. 36: 1110-20. PMID 25457558 DOI: 10.1016/J.Neurobiolaging.2014.07.047 |
0.589 |
|
| 2015 |
Sellnow RC, Steece-Collier K, Kanaan NM, Sortwell CE, Collier TJ, Cole-Strauss A, Lipton JW, Manfredsson FP. 709. rAAV-Mediated Regulation of Striatal Nurr1 Expression Alters Development and Severity of Levodopa-Induced Dyskinesias in the 6-OHDA Rat Model of Parkinson's Disease Molecular Therapy. 23: S282-S283. DOI: 10.1016/S1525-0016(16)34318-0 |
0.697 |
|
| 2015 |
Cox KK, Kanaan NM. P2-056: Differential oligomer formation and phosphatase-activating domain exposure in tau isoforms under reducing and oxidizing conditions in vitro Alzheimer's & Dementia. 11: P504-P504. DOI: 10.1016/J.Jalz.2015.06.593 |
0.345 |
|
| 2014 |
Kanaan NM, Himmelstein DS, Ward SM, Combs B, Binder LI. Tau Protein: Biology and Pathobiology Movement Disorders: Genetics and Models: Second Edition. 857-874. DOI: 10.1016/B978-0-12-405195-9.00056-1 |
0.715 |
|
| 2013 |
Kanaan NM, Pigino GF, Brady ST, Lazarov O, Binder LI, Morfini GA. Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental Neurology. 246: 44-53. PMID 22721767 DOI: 10.1016/J.Expneurol.2012.06.003 |
0.839 |
|
| 2012 |
Kanaan NM, Manfredsson FP. Loss of functional alpha-synuclein: a toxic event in Parkinson's disease? Journal of Parkinson's Disease. 2: 249-67. PMID 23938255 DOI: 10.3233/Jpd-012138 |
0.393 |
|
| 2012 |
Kanaan NM, Morfini G, Pigino G, LaPointe NE, Andreadis A, Song Y, Leitman E, Binder LI, Brady ST. Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiology of Aging. 33: 826.e15-30. PMID 21794954 DOI: 10.1016/J.Neurobiolaging.2011.06.006 |
0.845 |
|
| 2011 |
Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G, Brady ST, Gamblin TC, Binder LI. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry. 50: 10300-10. PMID 22039833 DOI: 10.1021/Bi2009147 |
0.836 |
|
| 2011 |
Vana L, Kanaan NM, Ugwu IC, Wuu J, Mufson EJ, Binder LI. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease. The American Journal of Pathology. 179: 2533-50. PMID 21945902 DOI: 10.1016/J.Ajpath.2011.07.044 |
0.716 |
|
| 2011 |
Kanaan NM, Morfini GA, LaPointe NE, Pigino GF, Patterson KR, Song Y, Andreadis A, Fu Y, Brady ST, Binder LI. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9858-68. PMID 21734277 DOI: 10.1523/Jneurosci.0560-11.2011 |
0.848 |
|
| 2011 |
Collier TJ, Kanaan NM, Kordower JH. Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates. Nature Reviews. Neuroscience. 12: 359-66. PMID 21587290 DOI: 10.1038/Nrn3039 |
0.605 |
|
| 2011 |
Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, Ward S, Reyes JF, Philibert K, Glucksman MJ, Binder LI. Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. The Journal of Biological Chemistry. 286: 23063-76. PMID 21550980 DOI: 10.1074/Jbc.M111.237974 |
0.83 |
|
| 2011 |
Reyes JF, Fu Y, Vana L, Kanaan NM, Binder LI. Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease. The American Journal of Pathology. 178: 2275-85. PMID 21514440 DOI: 10.1016/J.Ajpath.2011.01.030 |
0.823 |
|
| 2011 |
Vana L, Kanaan NM, Hakala K, Weintraub ST, Binder LI. Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation. Biochemistry. 50: 1203-12. PMID 21210655 DOI: 10.1021/Bi101735M |
0.696 |
|
| 2010 |
Kanaan NM, Kordower JH, Collier TJ. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiology of Aging. 31: 937-52. PMID 18715678 DOI: 10.1016/J.Neurobiolaging.2008.07.006 |
0.577 |
|
| 2009 |
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, et al. Axonal transport defects in neurodegenerative diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12776-86. PMID 19828789 DOI: 10.1523/Jneurosci.3463-09.2009 |
0.817 |
|
| 2008 |
Kanaan NM, Kordower JH, Collier TJ. Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration. The European Journal of Neuroscience. 27: 3205-15. PMID 18598263 DOI: 10.1111/J.1460-9568.2008.06307.X |
0.6 |
|
| 2008 |
Kanaan NM, Kordower JH, Collier TJ. Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. Glia. 56: 1199-214. PMID 18484101 DOI: 10.1002/Glia.20690 |
0.587 |
|
| 2007 |
Kanaan NM, Kordower JH, Collier TJ. Age-related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: relevance to selective neuronal vulnerability. The Journal of Comparative Neurology. 502: 683-700. PMID 17436290 DOI: 10.1002/Cne.21428 |
0.58 |
|
| 2006 |
Kordower JH, Kanaan NM, Chu Y, Suresh Babu R, Stansell J, Terpstra BT, Sortwell CE, Steece-Collier K, Collier TJ. Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys. Annals of Neurology. 60: 264-8. PMID 16862579 DOI: 10.1002/Ana.20935 |
0.706 |
|
| 2006 |
Kanaan NM, Collier TJ, Marchionini DM, McGuire SO, Fleming MF, Sortwell CE. Exogenous erythropoietin provides neuroprotection of grafted dopamine neurons in a rodent model of Parkinson's disease. Brain Research. 1068: 221-9. PMID 16368081 DOI: 10.1016/J.Brainres.2005.10.078 |
0.724 |
|
| 2006 |
Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Kanaan NM, Benzinger TL, Miller TM, Karch C, Bateman RJ. O3-01-03: TAU KINETICS IN NEURONS AND IN THE HUMAN CNS Alzheimer's & Dementia. 14: P1008-P1009. DOI: 10.1016/J.Jalz.2018.06.2772 |
0.404 |
|
| 2006 |
Combs B, Christensen K, Richards C, Kanaan NM. P3-181: THE INTERACTION BETWEEN TAU AND PROTEIN PHOSPHATASE 1 IS AFFECTED BY P301L MUTATION Alzheimer's & Dementia. 14: P1136-P1137. DOI: 10.1016/J.Jalz.2018.06.1539 |
0.783 |
|
| 2006 |
Terpstra B, Collier T, Kanaan N, Levine N, Wohlgenant S, Kordower J, Sortwell C. Re-evaluation of systemic proteasome inhibition as an animal model for Parkinson's disease Experimental Neurology. 198: 590-591. DOI: 10.1016/J.Expneurol.2006.02.096 |
0.691 |
|
| 2006 |
Kanaan N, Collier T. Intracellular inclusions: Differential accumulation in dopaminergic subregions of the midbrain during normal aging in the rhesus monkey Experimental Neurology. 198: 572-573. DOI: 10.1016/J.Expneurol.2006.02.052 |
0.55 |
|
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