Ted Hupp - Publications

University of Edinburgh, Edinburgh, Scotland, United Kingdom 

166 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Dias C, Nita E, Faktor J, Tynan AC, Hernychova L, Vojtesek B, Nylandsted J, Hupp TR, Kunath T, Ball KL. CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity. Iscience. 24: 102878. PMID 34401662 DOI: 10.1016/j.isci.2021.102878  1
2021 Ococks E, Sharma S, Tian Ng AW, Aleshin A, Fitzgerald RC, Smyth E, Fitzgerald RC, Edwards PAW, Grehan N, Nutzinger B, Fidziukiewicz E, Redmond AM, Northrop A, Abbas S, ... ... Hupp TR, et al. Serial ctDNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection. Gastroenterology. PMID 34284036 DOI: 10.1053/j.gastro.2021.07.011  1
2021 Pirog A, Faktor J, Urban-Wojciuk Z, Kote S, Chruściel E, Arcimowicz Ł, Marek-Trzonkowska N, Vojtesek B, Hupp TR, Al Shboul S, Brennan PM, Smoleński RT, Goodlett DR, Dapic I. Comparison of different digestion methods for proteomic analysis of isolated cells and FFPE tissue samples. Talanta. 233: 122568. PMID 34215064 DOI: 10.1016/j.talanta.2021.122568  1
2021 Białobrzeska W, Dziąbowska K, Lisowska M, Mohtar MA, Muller P, Vojtesek B, Krejcir R, O'Neill R, Hupp TR, Malinowska N, Bięga E, Bigus D, Cebula Z, Pala K, Czaczyk E, et al. An Ultrasensitive Biosensor for Detection of Femtogram Levels of the Cancer Antigen AGR2 Using Monoclonal Antibody Modified Screen-Printed Gold Electrodes. Biosensors. 11. PMID 34200338 DOI: 10.3390/bios11060184  1
2021 Kurkowiak M, Grasso G, Faktor J, Scheiblecker L, Winniczuk M, Mayordomo MY, O'Neill JR, Oster B, Vojtesek B, Al-Saadi A, Marek-Trzonkowska N, Hupp TR. An integrated DNA and RNA variant detector identifies a highly conserved three base exon in the kinase locus. Rna Biology. 1-20. PMID 34190025 DOI: 10.1080/15476286.2021.1932345  1
2021 Mikac S, Rychłowski M, Dziadosz A, Szabelska-Beresewicz A, Fahraeus R, Hupp T, Sznarkowska A. Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells. Antioxidants (Basel, Switzerland). 10. PMID 34063559 DOI: 10.3390/antiox10050786  1
2021 Padariya M, Sznarkowska A, Kote S, Gómez-Herranz M, Mikac S, Pilch M, Alfaro J, Fahraeus R, Hupp T, Kalathiya U. Functional Interfaces, Biological Pathways, and Regulations of Interferon-Related DNA Damage Resistance Signature (IRDS) Genes. Biomolecules. 11. PMID 33922087 DOI: 10.3390/biom11050622  1
2021 Salomao N, Karakostis K, Hupp T, Vollrath F, Vojtesek B, Fahraeus R. What do we need to know and understand about p53 to improve its clinical value? The Journal of Pathology. PMID 33826155 DOI: 10.1002/path.5677  1
2021 Kalathiya U, Padariya M, Faktor J, Coyaud E, Alfaro JA, Fahraeus R, Hupp TR, Goodlett DR. Interfaces with Structure Dynamics of the Workhorses from Cells Revealed through Cross-Linking Mass Spectrometry (CLMS). Biomolecules. 11. PMID 33806612 DOI: 10.3390/biom11030382  1
2021 Sicari D, Centonze FG, Pineau R, Le Reste PJ, Negroni L, Chat S, Mohtar MA, Thomas D, Gillet R, Hupp T, Chevet E, Igbaria A. Reflux of Endoplasmic Reticulum proteins to the cytosol inactivates tumor suppressors. Embo Reports. e51412. PMID 33710763 DOI: 10.15252/embr.202051412  1
2021 Kalathiya U, Padariya M, Fahraeus R, Chakraborti S, Hupp TR. Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages. Biomolecules. 11. PMID 33671255 DOI: 10.3390/biom11020297  1
2021 Kurkowiak M, Arcimowicz Ł, Chruściel E, Urban-Wójciuk Z, Papak I, Keegan L, O'Connell M, Kowalski J, Hupp T, Marek-Trzonkowska N. The effects of RNA editing in cancer tissue at different stages in carcinogenesis. Rna Biology. 1-16. PMID 33593231 DOI: 10.1080/15476286.2021.1877024  1
2021 Weke K, Singh A, Uwugiaren N, Alfaro JA, Wang T, Hupp TR, O'Neill JR, Vojtesek B, Goodlett DR, Williams SM, Zhou M, Kelly RT, Zhu Y, Dapic I. MicroPOTS Analysis of Barrett's Esophageal Cell Line Models Identifies Proteomic Changes after Physiologic and Radiation Stress. Journal of Proteome Research. PMID 33491460 DOI: 10.1021/acs.jproteome.0c00629  1
2020 Beirão BCB, Raposo TP, Imamura LM, Ingberman M, Hupp T, Vojtěšek B, Argyle DJ. A blocking antibody against canine CSF-1R maturated by limited CDR mutagenesis. Antibody Therapeutics. 3: 193-204. PMID 33937625 DOI: 10.1093/abt/tbaa018  1
2020 Uhrik L, Hernychova L, Muller P, Kalathiya U, Lisowska MM, Kocikowski M, Parys M, Faktor J, Nekulova M, Nortcliffe C, Zatloukalova P, Ruetgen B, Fahraeus R, Ball KL, Argyle DJ, ... ... Hupp T, et al. Hydrogen Deuterium Exchange Mass Spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody. The Biochemical Journal. PMID 33284343 DOI: 10.1042/BCJ20200674  1
2020 Bibi N, Hupp T, Kamal MA, Rashid S. Elucidation of PLK1 Linked Biomarkers in Oesophageal Cancer Cell Lines: A Step Towards Novel Signaling Pathways by p53 and PLK1- Linked Functions Crosstalk. Protein and Peptide Letters. PMID 32875973 DOI: 10.2174/0929866527999200901201837  1
2020 Li R, Zatloukalova P, Muller P, Gil-Mir M, Kote S, Wilkinson S, Kemp AJ, Hernychova L, Wang Y, Ball KL, Tao K, Hupp T, Vojtesek B. The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276. Cellular & Molecular Biology Letters. 25: 41. PMID 32874188 DOI: 10.1186/S11658-020-00233-W  1
2020 Faktor J, Grasso G, Zavadil F, Kurkowiak M, Mayordomo MY, Kote S, Singh A, Ruidong L, O'Neill JR, Muller P, Goodlett D, Vojtesek B, Hupp T. The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model. Biochimica Et Biophysica Acta. General Subjects. 129722. PMID 32866596 DOI: 10.1016/J.Bbagen.2020.129722  1
2020 Hughes RE, Elliott RJR, Munro AF, Makda A, O'Neill JR, Hupp T, Carragher NO. High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery. Slas Discovery : Advancing Life Sciences R & D. 2472555220917115. PMID 32441181 DOI: 10.1177/2472555220917115  1
2020 Katarzyna D, Kocikowski M, Vojtesek B, Argyle D, Lisowska M, Hupp T, Parys M. Abstract 5637: Investigating tumor intrinsic PD-1/PD-L1 signaling in canine osteosarcoma cell lines as a spontaneous model for human disease Immunology. DOI: 10.1158/1538-7445.Am2020-5637  1
2020 Kocikowski M, Dziubek K, Vojtesek B, Argyle D, Hupp T, Parys M. Abstract 2234: Development of caninized monoclonal antibodies against PD1 Immunology. DOI: 10.1158/1538-7445.Am2020-2234  1
2019 Kalathiya U, Padariya M, Pawlicka K, Verma CS, Houston D, Hupp TR, Alfaro JA. Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1. International Journal of Molecular Sciences. 20. PMID 31718065 DOI: 10.3390/ijms20225644  1
2019 Urban-Wojciuk Z, Khan MM, Oyler BL, Fåhraeus R, Marek-Trzonkowska N, Nita-Lazar A, Hupp TR, Goodlett DR. The Role of TLRs in Anti-cancer Immunity and Tumor Rejection. Frontiers in Immunology. 10: 2388. PMID 31695691 DOI: 10.3389/Fimmu.2019.02388  1
2019 Delom F, Mohtar MA, Hupp T, Fessart D. The AGR2 interactome. American Journal of Physiology. Cell Physiology. PMID 31644305 DOI: 10.1152/Ajpcell.00532.2018  1
2019 Kote S, Faktor J, Dapic I, Mayordomo MY, Kocikowski M, Kagansky A, Goodlett D, Vojtesek B, Hupp T, Wilcockson D, Piper R. Analysis of venom sac constituents from the solitary, hunting wasp Cerceris rybyensis. Toxicon : Official Journal of the International Society On Toxinology. PMID 31352010 DOI: 10.1016/J.Toxicon.2019.07.012  1
2019 Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, ... ... Hupp T, et al. Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation. Embo Molecular Medicine. PMID 31040128 DOI: 10.15252/Emmm.201810120  1
2019 Wang Q, Zhang X, Chen L, Weng S, Xia Y, Ye Y, Li K, Liao Z, Chen P, Alsamman K, Meng C, Stevens C, Hupp TR, Lin Y. Regulation of the Expression of DAPK1 by SUMO Pathway. Biomolecules. 9. PMID 30999631 DOI: 10.3390/biom9040151  1
2019 Gómez-Herranz M, Nekulova M, Faktor J, Hernychova L, Kote S, Sinclair EH, Nenutil R, Vojtesek B, Ball KL, Hupp TR. The effects of IFITM1 and IFITM3 gene deletion on IFNγ stimulated protein synthesis. Cellular Signalling. 60: 39-56. PMID 30951861 DOI: 10.1016/j.cellsig.2019.03.024  1
2019 Bibi N, Niaz H, Hupp T, Kamal MA, Rashid S. Screening and Identification of PLK1-Polo Box binding peptides by high-throughput sequencing of phage-selected libraries. Protein and Peptide Letters. PMID 30887917 DOI: 10.2174/0929866526666190318101054  1
2019 Coufalova D, Remnant L, Hernychova L, Muller P, Healy A, Kannan S, Vojtesek B, Westwood N, Verma CS, Vojtesek B, Hupp TR, Houston DR. An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin. Journal of Proteomics. PMID 30862565 DOI: 10.1016/J.Jprot.2019.02.012  1
2019 Nguyen MN, Sen N, Lin MY, Joseph TL, Vaz C, Tanavde V, Way L, Hupp TR, Verma CS, Madhusudhan MS. Discovering Putative Protein Targets of Small Molecules: A Study of the p53 Activator Nutlin. Journal of Chemical Information and Modeling. PMID 30794402 DOI: 10.1021/Acs.Jcim.8B00762  1
2019 Bibi N, Rashid S, Nicholson J, Malloy M, O'Neill R, Blake D, Hupp T. An integrative "omics" approach, for identification of bona fides PLK1 associated biomarker in Oesophgeal adenocarcinoma. Current Cancer Drug Targets. PMID 30747067 DOI: 10.2174/1568009619666190211113722  1
2019 Wang YJ, Pietrzak K, Kocikowski M, Argyle D, Hupp T, Parys M. Abstract 3972: Investigation of tumor intrinsic PD1/PD-L1 in canine urothelial carcinomas as a spontaneous translational model for human invasive bladder cancer Cancer Research. 79: 3972-3972. DOI: 10.1158/1538-7445.Am2019-3972  1
2018 Gu X, Coates PJ, Boldrup L, Wang L, Krejci A, Hupp T, Fahraeus R, Norberg-Spaak L, Sgaramella N, Wilms T, Nylander K. Copy number variation: a prognostic marker for young patients with squamous cell carcinoma of the oral tongue. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. PMID 30357923 DOI: 10.1111/Jop.12792  1
2018 Yuan M, McNae IW, Chen Y, Blackburn EA, Wear MA, Michels PAM, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD. An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. The Biochemical Journal. PMID 29748232 DOI: 10.1042/Bcj20180171  1
2018 Mohtar MA, Hernychova L, O'Neill R, Lawrence M, Murray E, Vojtesek B, Hupp TR. The sequence-specific peptide-binding activity of the protein sulfide isomerase AGR2 directs its' stable binding to the oncogenic receptor EpCAM. Molecular & Cellular Proteomics : McP. PMID 29339412 DOI: 10.1074/mcp.RA118.000573  1
2018 Parys M, Nekulová M, Vojtěšek B, Faktor J, Lima A, Hupp T. Abstract LB-115: Tumor intrinsic PD-1/PD-L1 signalling induces mesenchymal to epithelial transition in canine osteosarcoma cells Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-115  1
2017 McWhinnie FS, Sepp K, Wilson C, Kunath T, Hupp TR, Baker TS, Houston DR, Hulme AN. Mix and Match: Mono-substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29267987 DOI: 10.1002/Chem.201705983  0.01
2017 Muller P, Chan JM, Simoncik O, Fojta M, Lane DP, Hupp T, Vojtesek B. Evidence for allosteric effects on p53 oligomerization induced by phosphorylation. Protein Science : a Publication of the Protein Society. PMID 29124793 DOI: 10.1002/Pro.3344  1
2017 Landré V, Revi B, Mir MG, Verma C, Hupp TR, Gilbert N, Ball KL. Regulation of transcriptional activators by DNA-binding domain ubiquitination. Cell Death and Differentiation. PMID 28362432 DOI: 10.1038/Cdd.2017.42  1
2017 O'Neill JR, Pak HS, Pairo-Castineira E, Save V, Paterson-Brown S, Nenutil R, Vojtěšek B, Overton I, Scherl A, Hupp TR. Quantitative shotgun proteomics unveils candidate novel oesophageal adenocarcinoma-specific proteins. Molecular & Cellular Proteomics : McP. PMID 28336725 DOI: 10.1074/mcp.M116.065078  1
2016 Beirão BC, Raposo T, Jain S, Hupp T, Argyle DJ. Challenges and opportunities for monoclonal antibody therapy in veterinary oncology. Veterinary Journal (London, England : 1997). 218: 40-50. PMID 27938708 DOI: 10.1016/J.Tvjl.2016.11.005  1
2016 Way L, Faktor J, Dvorakova P, Nicholson J, Vojtesek B, Graham D, Ball KL, Hupp T. Rearrangement of Mitochondrial Pyruvate Dehydrogenase Subunit Dihydrolipoamide Dehydrogenase Protein-Protein Interactions by the MDM2 Ligand Nutlin-3. Proteomics. PMID 27273042 DOI: 10.1002/Pmic.201500501  1
2016 Jain S, Aresu L, Comazzi S, Shi J, Worrall E, Clayton J, Humphries W, Hemmington S, Davis P, Murray E, Limeneh AA, Ball K, Ruckova E, Muller P, Vojtesek B, ... ... Hupp TR, et al. The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine. Plos One. 11: e0148366. PMID 26894679 DOI: 10.1371/journal.pone.0148366  1
2016 Clarke DJ, Murray E, Faktor J, Mohtar A, Vojtesek B, MacKay CL, Smith PL, Hupp TR. Mass spectrometry analysis of the oxidation states of the pro-oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond. Biochimica Et Biophysica Acta. PMID 26876500 DOI: 10.1016/j.bbapap.2016.02.011  1
2015 Healy AR, Houston DR, Remnant L, Huart AS, Brychtova V, Maslon MM, Meers O, Muller P, Krejci A, Blackburn EA, Vojtesek B, Hernychova L, Walkinshaw MD, Westwood NJ, Hupp TR. Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin. Chemical Science. 6: 3109-3116. PMID 28706685 DOI: 10.1039/c4sc03885a  1
2015 Krejci A, Hupp TR, Lexa M, Vojtesek B, Muller P. Hammock: a hidden Markov model-based peptide clustering algorithm to identify protein-interaction consensus motifs in large datasets. Bioinformatics (Oxford, England). PMID 26342231 DOI: 10.1093/Bioinformatics/Btv522  1
2015 Dickinson ER, Jurneczko E, Nicholson J, Hupp TR, Zawacka-Pankau J, Selivanova G, Barran PE. The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors. Frontiers in Molecular Biosciences. 2: 39. PMID 26217671 DOI: 10.3389/Fmolb.2015.00039  1
2015 Marcar L, Ihrig B, Hourihan J, Bray SE, Quinlan PR, Jordan LB, Thompson AM, Hupp TR, Meek DW. MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4. Plos One. 10: e0127713. PMID 26001071 DOI: 10.1371/journal.pone.0127713  1
2015 Brychtova V, Mohtar A, Vojtesek B, Hupp TR. Mechanisms of anterior gradient-2 regulation and function in cancer. Seminars in Cancer Biology. 33: 16-24. PMID 25937245 DOI: 10.1016/j.semcancer.2015.04.005  1
2015 Dickinson ER, Jurneczko E, Pacholarz KJ, Clarke DJ, Reeves M, Ball KL, Hupp T, Campopiano D, Nikolova PV, Barran PE. Insights into the conformations of three structurally diverse proteins: cytochrome c, p53, and MDM2, provided by variable-temperature ion mobility mass spectrometry. Analytical Chemistry. 87: 3231-8. PMID 25629302 DOI: 10.1021/Ac503720V  1
2015 Fraser JA, Worrall EG, Lin Y, Landre V, Pettersson S, Blackburn E, Walkinshaw M, Muller P, Vojtesek B, Ball K, Hupp TR. Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis. Journal of Molecular Biology. 427: 1728-47. PMID 25543083 DOI: 10.1016/J.Jmb.2014.12.011  1
2015 Healy AR, Houston DR, Remnant L, Huart AS, Brychtova V, Maslon MM, Meers O, Muller P, Krejci A, Blackburn EA, Vojtesek B, Hernychova L, Walkinshaw MD, Westwood NJ, Hupp TR. Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin Chemical Science. 6: 3109-3116. DOI: 10.1039/c4sc03885a  1
2014 Gray TA, Alsamman K, Murray E, Sims AH, Hupp TR. Engineering a synthetic cell panel to identify signalling components reprogrammed by the cell growth regulator anterior gradient-2. Molecular Biosystems. 10: 1409-25. PMID 24710632 DOI: 10.1039/c4mb00113c  1
2014 Murray E, Hernychová L, Scigelova M, Ho J, Nekulova M, O'Neill JR, Nenutil R, Vesely K, Dundas SR, Dhaliwal C, Henderson H, Hayward RL, Salter DM, Vojtěšek B, Hupp TR. Quantitative proteomic profiling of pleomorphic human sarcoma identifies CLIC1 as a dominant pro-oncogenic receptor expressed in diverse sarcoma types. Journal of Proteome Research. 13: 2543-59. PMID 24661138 DOI: 10.1021/pr4010713  1
2014 Nicholson J, Scherl A, Way L, Blackburn EA, Walkinshaw MD, Ball KL, Hupp TR. A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2. Cellular Signalling. 26: 1243-57. PMID 24583282 DOI: 10.1016/j.cellsig.2014.02.011  1
2014 Dejeans N, Manié S, Hetz C, Bard F, Hupp T, Agostinis P, Samali A, Chevet E. Addicted to secrete - novel concepts and targets in cancer therapy. Trends in Molecular Medicine. 20: 242-50. PMID 24456621 DOI: 10.1016/J.Molmed.2013.12.003  1
2014 Pang LY, Gatenby EL, Kamida A, Whitelaw BA, Hupp TR, Argyle DJ. Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. Plos One. 9: e83144. PMID 24416158 DOI: 10.1371/journal.pone.0083144  1
2014 Kofod-Olsen E, Pettersson S, Wallace M, Abduljabar AB, Oster B, Hupp T, Höllsberg P. Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization. Virology. 448: 33-42. PMID 24314634 DOI: 10.1016/J.Virol.2013.10.002  1
2014 Huang Y, Chen L, Guo L, Hupp TR, Lin Y. Evaluating DAPK as a therapeutic target. Apoptosis : An International Journal On Programmed Cell Death. 19: 371-86. PMID 24305735 DOI: 10.1007/s10495-013-0919-2  1
2014 O'Neill R, Pak H, Nekulova M, Pairo-Castineira E, Save V, Paterson-Brown S, Scherl A, Vojtesek B, Overton I, Hupp T. A novel strategy to exploit metabolic dysregulation in oesophageal adenocarcinoma abolishes cancer cell proliferation British Journal of Surgery. 101: 3-4. DOI: 10.1002/Bjs.9508  1
2013 Huart AS, Saxty B, Merritt A, Nekulova M, Lewis S, Huang Y, Vojtesek B, Kettleborough C, Hupp TR. A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway. Bioorganic & Medicinal Chemistry Letters. 23: 5578-85. PMID 24007918 DOI: 10.1016/j.bmcl.2013.08.046  1
2013 Gray TA, Murray E, Nowicki MW, Remnant L, Scherl A, Muller P, Vojtesek B, Hupp TR. Development of a fluorescent monoclonal antibody-based assay to measure the allosteric effects of synthetic peptides on self-oligomerization of AGR2 protein. Protein Science : a Publication of the Protein Society. 22: 1266-78. PMID 23780840 DOI: 10.1002/pro.2299  1
2013 Hernychova L, Man P, Verma C, Nicholson J, Sharma CA, Ruckova E, Teo JY, Ball K, Vojtesek B, Hupp TR. Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry. Proteomics. 13: 2512-25. PMID 23776060 DOI: 10.1002/Pmic.201300029  1
2013 Kofod-Olsen E, Møller JM, Schleimann MH, Bundgaard B, Bak RO, Øster B, Mikkelsen JG, Hupp T, Höllsberg P. Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. Plos One. 8: e59223. PMID 23555634 DOI: 10.1371/Journal.Pone.0059223  1
2013 Morgan HP, O'Reilly FJ, Wear MA, O'Neill JR, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD. M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 110: 5881-6. PMID 23530218 DOI: 10.1073/Pnas.1217157110  1
2013 Rosenbaum J, Baek SH, Dutta A, Houry WA, Huber O, Hupp TR, Matias PM. The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape. Science Signaling. 6: mr1. PMID 23482663 DOI: 10.1126/Scisignal.2003906  1
2013 Hrstka R, Murray E, Brychtova V, Fabian P, Hupp TR, Vojtesek B. Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2. Cancer Letters. 333: 187-93. PMID 23354592 DOI: 10.1016/j.canlet.2013.01.034  1
2013 Pettersson S, Sczaniecka M, McLaren L, Russell F, Gladstone K, Hupp T, Wallace M. Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway. The Biochemical Journal. 450: 523-36. PMID 23252402 DOI: 10.1042/Bj20121249  1
2013 Chevet E, Fessart D, Delom F, Mulot A, Vojtesek B, Hrstka R, Murray E, Gray T, Hupp T. Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development. Oncogene. 32: 2499-509. PMID 22945652 DOI: 10.1038/Onc.2012.346  1
2013 Scotcher J, Clarke DJ, MacKay CL, Hupp T, Sadler PJ, Langridge-Smith PRR. Redox regulation of tumour suppressor protein p53: Identification of the sites of hydrogen peroxide oxidation and glutathionylation Chemical Science. 4: 1257-1269. DOI: 10.1039/C2Sc21702C  1
2012 Ponnuswamy A, Hupp T, Fåhraeus R. Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops. Genes & Cancer. 3: 291-7. PMID 23150762 DOI: 10.1177/1947601912454140  1
2012 Nicholson J, Neelagandan K, Huart AS, Ball K, Molloy MP, Hupp T. An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis. Journal of Proteome Research. 11: 5464-78. PMID 23039052 DOI: 10.1021/Pr300698D  1
2012 Morelli X, Hupp T. Searching for the Holy Grail; protein-protein interaction analysis and modulation. Embo Reports. 13: 877-9. PMID 22986552 DOI: 10.1038/Embor.2012.137  0.01
2012 Hupp TR, Hayward RL, Vojtesek B. Strategies for p53 reactivation in human sarcoma. Cancer Cell. 22: 283-5. PMID 22975370 DOI: 10.1016/j.ccr.2012.08.020  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Hupp TR, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  1
2012 Huart AS, MacLaine NJ, Narayan V, Hupp TR. Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth. Plos One. 7: e43391. PMID 22916255 DOI: 10.1371/journal.pone.0043391  1
2012 Robson AF, Hupp TR, Lickiss F, Ball KL, Faulds K, Graham D. Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay. Proceedings of the National Academy of Sciences of the United States of America. 109: 8073-8. PMID 22556265 DOI: 10.1073/pnas.1116637109  1
2012 Gray TA, MacLaine NJ, Michie CO, Bouchalova P, Murray E, Howie J, Hrstka R, Maslon MM, Nenutil R, Vojtesek B, Langdon S, Hayward L, Gourley C, Hupp TR. Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models. Journal of Immunological Methods. 378: 20-32. PMID 22361111 DOI: 10.1016/J.Jim.2012.01.013  1
2012 Frame S, Aspinall C, O'Neil R, Hollick J, Taylor S, Hupp T, Blake D, Zheleva DI. Abstract 2814: Potent and selective small molecule inhibitors of polo-like kinase 1: Biological characterization Cancer Research. 72: 2814-2814. DOI: 10.1158/1538-7445.Am2012-2814  1
2011 Clarke DJ, Murray E, Hupp T, Mackay CL, Langridge-Smith PR. Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation. Journal of the American Society For Mass Spectrometry. 22: 1432-40. PMID 21953198 DOI: 10.1007/S13361-011-0155-3  1
2011 Hengel SM, Murray E, Langdon S, Hayward L, O'Donoghue J, Panchaud A, Hupp T, Goodlett DR. Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance. Journal of Proteome Research. 10: 4567-78. PMID 21936522 DOI: 10.1021/Pr2004117  1
2011 Hollstein M, Hupp T. Chek2ing out the p53 pathway: can Puma lead the way? Cell Cycle (Georgetown, Tex.). 10: 1524. PMID 21478674 DOI: 10.4161/Cc.10.10.15514  0.01
2011 Scotcher J, Clarke DJ, Weidt SK, Mackay CL, Hupp TR, Sadler PJ, Langridge-Smith PR. Identification of two reactive cysteine residues in the tumor suppressor protein p53 using top-down FTICR mass spectrometry. Journal of the American Society For Mass Spectrometry. 22: 888-97. PMID 21472523 DOI: 10.1007/S13361-011-0088-X  1
2011 Pang LY, Scott M, Hayward RL, Mohammed H, Whitelaw CB, Smith GC, Hupp TR. p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program. Cell Cycle (Georgetown, Tex.). 10: 932-50. PMID 21368573  1
2011 MacLaine NJ, Hupp TR. How phosphorylation controls p53. Cell Cycle (Georgetown, Tex.). 10: 916-21. PMID 21350334 DOI: 10.4161/cc.10.6.15076  1
2011 Narayan V, Halada P, Hernychová L, Chong YP, Žáková J, Hupp TR, Vojtesek B, Ball KL. A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1. The Journal of Biological Chemistry. 286: 14291-303. PMID 21245151 DOI: 10.1074/jbc.M110.204602  1
2011 Dastidar SG, Raghunathan D, Nicholson J, Hupp TR, Lane DP, Verma CS. Chemical states of the N-terminal "lid" of MDM2 regulate p53 binding: simulations reveal complexities of modulation. Cell Cycle (Georgetown, Tex.). 10: 82-9. PMID 21191186 DOI: 10.4161/Cc.10.1.14345  1
2011 Lin Y, Henderson P, Pettersson S, Satsangi J, Hupp T, Stevens C. Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. The Febs Journal. 278: 354-70. PMID 21134130 DOI: 10.1111/j.1742-4658.2010.07959.x  1
2010 Marcar L, Maclaine NJ, Hupp TR, Meek DW. Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin. Cancer Research. 70: 10362-70. PMID 21056992 DOI: 10.1158/0008-5472.CAN-10-1341  1
2010 Maslon MM, Hrstka R, Vojtesek B, Hupp TR. A divergent substrate-binding loop within the pro-oncogenic protein anterior gradient-2 forms a docking site for Reptin. Journal of Molecular Biology. 404: 418-38. PMID 20888340 DOI: 10.1016/j.jmb.2010.09.035  1
2010 Fraser JA, Vojtesek B, Hupp TR. A novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. Phosphorylation at SER269 in vivo is linked to inactivation of p53 function Journal of Biological Chemistry. 285: 37762-37772. PMID 20851891 DOI: 10.1074/jbc.M110.143099  1
2010 Fraser JA, Madhumalar A, Blackburn E, Bramham J, Walkinshaw MD, Verma C, Hupp TR. A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. A model in which phosphorylation at Ser269 induces a mutant conformation to p53 Journal of Biological Chemistry. 285: 37773-37786. PMID 20847049 DOI: 10.1074/Jbc.M110.143107  1
2010 Craig AL, Holcakova J, Finlan LE, Nekulova M, Hrstka R, Gueven N, DiRenzo J, Smith G, Hupp TR, Vojtesek B. DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Molecular Cancer. 9: 195. PMID 20663147 DOI: 10.1186/1476-4598-9-195  1
2010 Maslon MM, Hupp TR. Drug discovery and mutant p53. Trends in Cell Biology. 20: 542-55. PMID 20656489 DOI: 10.1016/j.tcb.2010.06.005  1
2010 Hrstka R, Nenutil R, Fourtouna A, Maslon MM, Naughton C, Langdon S, Murray E, Larionov A, Petrakova K, Muller P, Dixon MJ, Hupp TR, Vojtesek B. The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers. Oncogene. 29: 4838-47. PMID 20531310 DOI: 10.1038/Onc.2010.228  1
2010 Nicholson J, Hupp TR. The molecular dynamics of MDM2. Cell Cycle (Georgetown, Tex.). 9: 1878-81. PMID 20436290 DOI: 10.4161/cc.9.10.11597  1
2010 Worrall EG, Worrall L, Blackburn E, Walkinshaw M, Hupp TR. The effects of phosphomimetic lid mutation on the thermostability of the N-terminal domain of MDM2. Journal of Molecular Biology. 398: 414-28. PMID 20303977 DOI: 10.1016/j.jmb.2010.03.023  1
2010 Meek DW, Hupp TR. The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours? Seminars in Cancer Biology. 20: 19-28. PMID 19897041 DOI: 10.1016/j.semcancer.2009.10.005  1
2010 Hupp TR. Death-associated protein kinase (DAPK) and signal transduction. The Febs Journal. 277: 47. PMID 19878314 DOI: 10.1111/j.1742-4658.2009.07410.x  0.01
2010 Lin Y, Hupp TR, Stevens C. Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. The Febs Journal. 277: 48-57. PMID 19878313 DOI: 10.1111/j.1742-4658.2009.07411.x  1
2009 Maclaine NJ, Hupp TR. The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging. 1: 490-502. PMID 20157532 DOI: 10.18632/aging.100047  1
2009 Huart AS, MacLaine NJ, Meek DW, Hupp TR. CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. The Journal of Biological Chemistry. 284: 32384-94. PMID 19759023 DOI: 10.1074/jbc.M109.052647  1
2009 Worrall EG, Wawrzynow B, Worrall L, Walkinshaw M, Ball KL, Hupp TR. Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif. Journal of Chemical Biology. 2: 113-29. PMID 19568783 DOI: 10.1007/s12154-009-0019-5  1
2009 Clyde RG, Craig AL, de Breed L, Bown JL, Forrester L, Vojtesek B, Smith G, Hupp T, Crawford J. A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells. Journal of the Royal Society, Interface / the Royal Society. 6: 1167-77. PMID 19324671 DOI: 10.1098/rsif.2008.0538  1
2009 Lin Y, Stevens C, Harrison B, Pathuri S, Amin E, Hupp TR. The alternative splice variant of DAPK-1, s-DAPK-1, induces proteasome-independent DAPK-1 destabilization. Molecular and Cellular Biochemistry. 328: 101-7. PMID 19267229 DOI: 10.1007/s11010-009-0079-4  1
2009 Wawrzynow B, Pettersson S, Zylicz A, Bramham J, Worrall E, Hupp TR, Ball KL. A function for the RING finger domain in the allosteric control of MDM2 conformation and activity. The Journal of Biological Chemistry. 284: 11517-30. PMID 19188367 DOI: 10.1074/jbc.M809294200  1
2009 Stevens C, Lin Y, Harrison B, Burch L, Ridgway RA, Sansom O, Hupp T. Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. The Journal of Biological Chemistry. 284: 334-44. PMID 18974095 DOI: 10.1074/Jbc.M805165200  1
2008 Pang LY, Hupp TR. Protein kinases coordinately regulate the p53: Delta Np63 alpha axis after DNA damage. Cell Cycle (Georgetown, Tex.). 7: 2779-80. PMID 18797190 DOI: 10.4161/cc.7.18.6891  1
2008 Groome M, Lindsay J, Ross PE, Cotton JP, Hupp TR, Dillon JF. Use of oesophageal stress response proteins as potential biomarkers in the screening for Barrett's oesophagus. European Journal of Gastroenterology & Hepatology. 20: 961-5. PMID 18787461 DOI: 10.1097/MEG.0b013e3282ffd9bd  1
2008 Stevens C, Pettersson S, Wawrzynow B, Wallace M, Ball K, Zylicz A, Hupp TR. ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1. The Febs Journal. 275: 4875-86. PMID 18754770 DOI: 10.1111/j.1742-4658.2008.06627.x  1
2008 MacLaine NJ, Oster B, Bundgaard B, Fraser JA, Buckner C, Lazo PA, Meek DW, Höllsberg P, Hupp TR. A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection. The Journal of Biological Chemistry. 283: 28563-73. PMID 18669630 DOI: 10.1074/jbc.M804433200  1
2008 Nelson L, Anderson S, Archibald AL, Rhind S, Lu ZH, Condie A, McIntyre N, Thompson J, Nenutil R, Vojtesek B, Whitelaw CBA, Little TJ, Hupp T. An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses Cell Stress and Chaperones. 13: 375-385. PMID 18465210 DOI: 10.1007/S12192-008-0037-1  1
2008 Mackay CL, Ramsahoye B, Burgess K, Cook K, Weidt S, Creanor J, Harrison D, Langridge-Smith P, Hupp T, Hayward L. Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. Analytical Chemistry. 80: 4147-53. PMID 18457408 DOI: 10.1021/Ac702452D  1
2008 Lin Y, Stevens C, Hrstka R, Harrison B, Fourtouna A, Pathuri S, Vojtesek B, Hupp T. An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing. The Febs Journal. 275: 2574-84. PMID 18422656 DOI: 10.1111/J.1742-4658.2008.06404.X  1
2008 Stevens C, Hupp TR. Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens. Autophagy. 4: 531-3. PMID 18376136  1
2008 Harrison B, Kraus M, Burch L, Stevens C, Craig A, Gordon-Weeks P, Hupp TR. DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. The Journal of Biological Chemistry. 283: 9999-10014. PMID 18195017 DOI: 10.1074/Jbc.M706040200  1
2008 Oster B, Bundgaard B, Hupp TR, Höllsberg P. Human herpesvirus 6B induces phosphorylation of p53 in its regulatory domain by a CK2- and p38-independent pathway. The Journal of General Virology. 89: 87-96. PMID 18089732 DOI: 10.1099/vir.0.83136-0  1
2007 Murray E, McKenna EO, Burch LR, Dillon J, Langridge-Smith P, Kolch W, Pitt A, Hupp TR. Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2. Biochemistry. 46: 13742-51. PMID 17994709 DOI: 10.1021/bi7008739  1
2007 Little TJ, Nelson L, Hupp T. Adaptive evolution of a stress response protein Plos One. 2. PMID 17925851 DOI: 10.1371/Journal.Pone.0001003  1
2007 Hupp TR, Walkinshaw M. Multienzyme assembly of a p53 transcription complex. Nature Structural & Molecular Biology. 14: 885-7. PMID 17912258 DOI: 10.1038/nsmb1007-885  1
2007 Wawrzynow B, Zylicz A, Wallace M, Hupp T, Zylicz M. MDM2 chaperones the p53 tumor suppressor. The Journal of Biological Chemistry. 282: 32603-12. PMID 17848574 DOI: 10.1074/Jbc.M702767200  1
2007 Din S, Lennon AM, Arnott ID, Hupp T, Satsangi J. Technology insight: the application of proteomics in gastrointestinal disease. Nature Clinical Practice. Gastroenterology & Hepatology. 4: 372-85. PMID 17607293 DOI: 10.1038/Ncpgasthep0872  1
2007 Finlan LE, Hupp TR. p63: the phantom of the tumor suppressor. Cell Cycle (Georgetown, Tex.). 6: 1062-71. PMID 17426453 DOI: 10.4161/cc.6.9.4162  1
2007 Craig AL, Chrystal JA, Fraser JA, Sphyris N, Lin Y, Harrison BJ, Scott MT, Dornreiter I, Hupp TR. The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members. Molecular and Cellular Biology. 27: 3542-55. PMID 17339337 DOI: 10.1128/MCB.01595-06  1
2007 Lin Y, Stevens C, Hupp T. Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. The Journal of Biological Chemistry. 282: 16792-802. PMID 17324927 DOI: 10.1074/Jbc.M611559200  1
2007 Fraser JA, Hupp TR. Chemical genetics approach to identify peptide ligands that selectively stimulate DAPK-1 kinase activity. Biochemistry. 46: 2655-73. PMID 17297916 DOI: 10.1021/bi061562j  1
2007 Stevens C, Lin Y, Sanchez M, Amin E, Copson E, White H, Durston V, Eccles DM, Hupp T. A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis. The Journal of Biological Chemistry. 282: 13791-803. PMID 17244621 DOI: 10.1074/Jbc.M605649200  1
2006 Finlan LE, Nenutil R, Ibbotson SH, Vojtesek B, Hupp TR. CK2-site phosphorylation of p53 is induced in DeltaNp63 expressing basal stem cells in UVB irradiated human skin. Cell Cycle (Georgetown, Tex.). 5: 2489-94. PMID 17106255 DOI: 10.4161/cc.5.21.3393  1
2006 Clyde RG, Bown JL, Hupp TR, Zhelev N, Crawford JW. The role of modelling in identifying drug targets for diseases of the cell cycle. Journal of the Royal Society, Interface. 3: 617-27. PMID 16971330 DOI: 10.1098/rsif.2006.0146  1
2006 Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL. Dual-site regulation of MDM2 E3-ubiquitin ligase activity. Molecular Cell. 23: 251-63. PMID 16857591 DOI: 10.1016/j.molcel.2006.05.029  1
2006 Darragh J, Hunter M, Pohler E, Nelson L, Dillon JF, Nenutil R, Vojtesek B, Ross PE, Kernohan N, Hupp TR. The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury. The Febs Journal. 273: 1930-47. PMID 16640557 DOI: 10.1111/j.1742-4658.2006.05206.x  1
2006 Shimizu H, Saliba D, Wallace M, Finlan L, Langridge-Smith PR, Hupp TR. Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo. The Biochemical Journal. 397: 355-67. PMID 16579792 DOI: 10.1042/Bj20051521  1
2006 Cesková P, Chichger H, Wallace M, Vojtesek B, Hupp TR. On the mechanism of sequence-specific DNA-dependent acetylation of p53: the acetylation motif is exposed upon DNA binding. Journal of Molecular Biology. 357: 442-56. PMID 16438982 DOI: 10.1016/j.jmb.2005.12.026  1
2005 Finlan LE, Kernohan NM, Thomson G, Beattie PE, Hupp TR, Ibbotson SH. Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo. The British Journal of Dermatology. 153: 1001-10. PMID 16225614 DOI: 10.1111/j.1365-2133.2005.06922.x  1
2005 Beattie PE, Finlan LE, Kernohan NM, Thomson G, Hupp TR, Ibbotson SH. The effect of ultraviolet (UV) A1, UVB and solar-simulated radiation on p53 activation and p21. The British Journal of Dermatology. 152: 1001-8. PMID 15888160 DOI: 10.1111/j.1365-2133.2005.06557.x  1
2004 Dornan D, Eckert M, Wallace M, Shimizu H, Ramsay E, Hupp TR, Ball KL. Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. Molecular and Cellular Biology. 24: 10083-98. PMID 15509808 DOI: 10.1128/MCB.24.22.10083-10098.2004  1
2004 Craig AL, Hupp TR. The regulation of CHK2 in human cancer. Oncogene. 23: 8411-8. PMID 15361833 DOI: 10.1038/sj.onc.1208035  1
2004 Finlan L, Hupp TR. The N-terminal interferon-binding domain (IBiD) homology domain of p300 binds to peptides with homology to the p53 transactivation domain. The Journal of Biological Chemistry. 279: 49395-405. PMID 15337767 DOI: 10.1074/jbc.M405974200  1
2004 Burch L, Shimizu H, Smith A, Patterson C, Hupp TR. Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. Journal of Molecular Biology. 337: 129-45. PMID 15001357 DOI: 10.1016/J.Jmb.2004.01.017  1
2004 Burch LR, Scott M, Pohler E, Meek D, Hupp T. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. Journal of Molecular Biology. 337: 115-28. PMID 15001356 DOI: 10.1016/j.jmb.2003.10.081  1
2004 Pohler E, Craig AL, Cotton J, Lawrie L, Dillon JF, Ross P, Kernohan N, Hupp TR. The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. Molecular & Cellular Proteomics : McP. 3: 534-47. PMID 14967811 DOI: 10.1074/mcp.M300089-MCP200  1
2004 Pospísilová S, Brázda V, Kucharíková K, Luciani MG, Hupp TR, Skládal P, Palecek E, Vojtesek B. Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2. The Biochemical Journal. 378: 939-47. PMID 14640983 DOI: 10.1042/BJ20030662  1
2003 Dornan D, Shimizu H, Burch L, Smith AJ, Hupp TR. The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Molecular and Cellular Biology. 23: 8846-61. PMID 14612423  1
2003 Craig A, Scott M, Burch L, Smith G, Ball K, Hupp T. Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. Embo Reports. 4: 787-92. PMID 12897801 DOI: 10.1038/sj.embor.embor901  1
2003 Shimizu H, Hupp TR. Intrasteric regulation of MDM2. Trends in Biochemical Sciences. 28: 346-9. PMID 12877998 DOI: 10.1016/S0968-0004(03)00140-3  1
2003 Craig AL, Bray SE, Finlan LE, Kernohan NM, Hupp TR. Signaling to p53: the use of phospho-specific antibodies to probe for in vivo kinase activation. Methods in Molecular Biology (Clifton, N.J.). 234: 171-202. PMID 12824532 DOI: 10.1385/1-59259-408-5:171  1
2003 Lane DP, Hupp TR. Drug discovery and p53. Drug Discovery Today. 8: 347-55. PMID 12681938 DOI: 10.1016/S1359-6446(03)02669-2  1
2001 Ball HL, Hupp TR, Ziyaie D, Purdie CA, Kernohan NM, Thompson AM. Differential p53 protein expression in breast cancer fine needle aspirates: The potential for in vivo monitoring British Journal of Cancer. 85: 1102-1105. PMID 11710820 DOI: 10.1054/bjoc.2001.2064  1
2000 Luciani MG, Hutchins JR, Zheleva D, Hupp TR. The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. Journal of Molecular Biology. 300: 503-18. PMID 10884347 DOI: 10.1006/jmbi.2000.3830  1
2000 HUPP TR, LANE DP, BALL KL. Strategies for manipulating the p53 pathway in the treatment of human cancer Biochemical Journal. 352: 1. DOI: 10.1042/0264-6021:3520001  0.32
1999 Cohen PA, Hupp TR, Lane DP, Daniels DA. Biochemical characterization of different conformational states of the Sf9 cell-purified p53His175 mutant protein. Febs Letters. 463: 179-84. PMID 10601663 DOI: 10.1016/S0014-5793(99)01603-8  1
1999 Blaydes JP, Sparks A, Hupp TR. Activation of p53 protein function in response to cellular irradiation Methods in Molecular Biology (Clifton, N.J.). 113: 591-598. PMID 10443454 DOI: 10.1385/1-59259-675-4:591  1
1997 Mundt M, Hupp T, Fritsche M, Merkle C, Hansen S, Lane D, Groner B. Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential Oncogene. 15: 237-244. PMID 9244359 DOI: 10.1038/Sj.Onc.1201174  0.12
1997 Fourie AM, Hupp TR, Lane DP, Sang BC, Barbosa MS, Sambrook JF, Gething MJ. HSP70 binding sites in the tumor suppressor protein p53. The Journal of Biological Chemistry. 272: 19471-9. PMID 9235949 DOI: 10.1074/jbc.272.31.19471  1
1996 Hansen S, Midgley CA, Lane DP, Freeman BC, Morimoto RI, Hupp TR. Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70. The Journal of Biological Chemistry. 271: 30922-8. PMID 8940078 DOI: 10.1074/Jbc.271.48.30922  1
1996 Marszalek J, Zhang W, Hupp TR, Margulies C, Carr KM, Cherry S, Kaguni JM. Domains of DnaA protein involved in interaction with DnaB protein, and in unwinding the Escherichia coli chromosomal origin. The Journal of Biological Chemistry. 271: 18535-42. PMID 8702501 DOI: 10.1074/Jbc.271.31.18535  1
1996 Kernohan NM, Hupp TR, Lane DP. Modification of an N-terminal regulatory domain of T antigen restores p53-T antigen complex formation in the absence of an essential metal ion cofactor. The Journal of Biological Chemistry. 271: 4954-60. PMID 8617769 DOI: 10.1074/Jbc.271.9.4954  0.48
1995 Hupp TR, Lane DP. Allosteric activation of latent p53 tetramers. Current Biology : Cb. 4: 865-75. PMID 7850419 DOI: 10.1016/S0960-9822(00)00195-0  0.52
1995 Hupp TR, Lane DP. Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner. The Journal of Biological Chemistry. 270: 18165-74. PMID 7629129 DOI: 10.1074/Jbc.270.30.18165  0.44
1995 Hupp TR, Lane DP. Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. Cold Spring Harbor Symposia On Quantitative Biology. 59: 195-206. PMID 7587070 DOI: 10.1101/SQB.1994.059.01.024  0.72
1995 Hupp TR, Sparks A, Lane DP. Small peptides activate the latent sequence-specific DNA binding function of p53 Cell. 83: 237-245. PMID 7585941 DOI: 10.1016/0092-8674(95)90165-5  1
1994 Picksley SM, Hupp TR, Lu X, Midgley CA, Vojtesek B, Lane DP. Regulation of p53 protein expression in human cancer Cancer Genetics and Cytogenetics. 77: 153. DOI: 10.1016/0165-4608(94)90250-X  1
1993 Lane DP, Midgley C, Hupp T. Tumour suppressor genes and molecular chaperones. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 339: 369-72; discussion 3. PMID 8493291 DOI: 10.1098/Rstb.1993.0036  1
1993 Hupp TR, Meek DW, Midgley CA, Lane DP. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Research. 21: 3167-74. PMID 8341590 DOI: 10.1093/Nar/21.14.3167  1
1992 Hupp TR, Meek DW, Midgley CA, Lane DP. Regulation of the specific DNA binding function of p53. Cell. 71: 875-86. PMID 1423635 DOI: 10.1016/0092-8674(92)90562-Q  1
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