| Year |
Citation |
Score |
| 2020 |
Roper RJ, Goodlett CR, Martínez de Lagrán M, Dierssen M. Behavioral Phenotyping for Down Syndrome in Mice. Current Protocols in Mouse Biology. 10: e79. PMID 32780566 DOI: 10.1002/Cpmo.79 |
0.34 |
|
| 2020 |
Dierssen M, Fructuoso M, Martínez de Lagrán M, Perluigi M, Barone E. Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions. Frontiers in Neuroscience. 14: 670. PMID 32733190 DOI: 10.3389/Fnins.2020.00670 |
0.338 |
|
| 2020 |
Fructuoso M, Gu YC, Kassis N, de Lagran MM, Dierssen M, Janel N. Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Molecular Neurobiology. 57: 3195-3205. PMID 32504418 DOI: 10.1007/S12035-020-01967-6 |
0.319 |
|
| 2020 |
Alemany-González M, Gener T, Nebot P, Vilademunt M, Dierssen M, Puig MV. Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability. Proceedings of the National Academy of Sciences of the United States of America. 117: 11788-11798. PMID 32393630 DOI: 10.1073/Pnas.1921314117 |
0.342 |
|
| 2020 |
Gu Y, Moroy G, Paul JL, Rebillat AS, Dierssen M, de la Torre R, Cieuta-Walti C, Dairou J, Janel N. Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup Dietary Supplement: Role of Green Tea Catechins. International Journal of Molecular Sciences. 21. PMID 32092951 DOI: 10.3390/Ijms21041404 |
0.367 |
|
| 2020 |
Martínez Cué C, Dierssen M. Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome. Progress in Brain Research. 251: 269-302. PMID 32057310 DOI: 10.1016/Bs.Pbr.2019.11.001 |
0.365 |
|
| 2020 |
Rueda N, Flórez J, Dierssen M, Martínez-Cué C. Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome. Progress in Brain Research. 251: 245-268. PMID 32057309 DOI: 10.1016/Bs.Pbr.2019.10.001 |
0.581 |
|
| 2019 |
De Toma I, Ortega M, Aloy P, Sabidó E, Dierssen M. DYRK1A Overexpression Alters Cognition and Neural-Related Proteomic Pathways in the Hippocampus That Are Rescued by Green Tea Extract and/or Environmental Enrichment. Frontiers in Molecular Neuroscience. 12: 272. PMID 31803016 DOI: 10.3389/Fnmol.2019.00272 |
0.359 |
|
| 2019 |
Navarro-Romero A, Vázquez-Oliver A, Gomis-González M, Garzón-Montesinos C, Falcón-Moya R, Pastor A, Martín-García E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodríguez-Moreno A, et al. Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome. Neurobiology of Disease. 125: 92-106. PMID 30685352 DOI: 10.1016/J.Nbd.2019.01.014 |
0.414 |
|
| 2018 |
Faundez V, De Toma I, Bardoni B, Bartesaghi R, Nizetic D, de la Torre R, Cohen Kadosh R, Herault Y, Dierssen M, Potier MC. Translating molecular advances in Down syndrome and Fragile X syndrome into therapies. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 29887288 DOI: 10.1016/S0924-977X(17)31089-1 |
0.336 |
|
| 2017 |
Gómez-Grau M, Albaigès J, Casas J, Auladell C, Dierssen M, Vilageliu L, Grinberg D. New murine Niemann-Pick type C models bearing a pseudoexon-generating mutation recapitulate the main neurobehavioural and molecular features of the disease. Scientific Reports. 7: 41931. PMID 28167839 DOI: 10.1038/Srep41931 |
0.304 |
|
| 2016 |
Delabar JM, Allinquant B, Bianchi D, Blumenthal T, Dekker A, Edgin J, O'Bryan J, Dierssen M, Potier MC, Wiseman F, Guedj F, Créau N, Reeves R, Gardiner K, Busciglio J. Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society. Molecular Syndromology. 7: 251-261. PMID 27867340 DOI: 10.1159/000449049 |
0.334 |
|
| 2016 |
Del Hoyo L, Xicota L, Langohr K, Sánchez-Benavides G, de Sola S, Cuenca-Royo A, Rodriguez J, Rodríguez-Morató J, Farré M, Dierssen M, de la Torre R. VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome. Frontiers in Behavioral Neuroscience. 10: 193. PMID 27799900 DOI: 10.3389/Fnbeh.2016.00193 |
0.339 |
|
| 2016 |
De Toma I, Manubens-Gil L, Ossowski S, Dierssen M. Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders. Neural Plasticity. 2016: 4235898. PMID 27547454 DOI: 10.1155/2016/4235898 |
0.348 |
|
| 2016 |
D'Amico D, Gener T, de Lagrán MM, Sanchez-Vives MV, Santos M, Dierssen M. Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27534266 DOI: 10.1038/Npp.2016.154 |
0.327 |
|
| 2016 |
de la Torre R, de Sola S, Hernandez G, Farré M, Pujol J, Rodriguez J, Espadaler JM, Langohr K, Cuenca-Royo A, Principe A, Xicota L, Janel N, Catuara-Solarz S, Sanchez-Benavides G, Bléhaut H, ... ... Dierssen M, et al. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet. Neurology. 15: 801-10. PMID 27302362 DOI: 10.1016/S1474-4422(16)30034-5 |
0.308 |
|
| 2016 |
Ruiz-Mejias M, Martinez de Lagran M, Mattia M, Castano-Prat P, Perez-Mendez L, Ciria-Suarez L, Gener T, Sancristobal B, García-Ojalvo J, Gruart A, Delgado-García JM, Sanchez-Vives MV, Dierssen M. Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3648-59. PMID 27030752 DOI: 10.1523/Jneurosci.2517-15.2016 |
0.353 |
|
| 2015 |
Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Notredame C, Gonzalez JR, Dierssen M. Principal Component Analysis of the Effects of Environmental Enrichment and (-)-epigallocatechin-3-gallate on Age-Associated Learning Deficits in a Mouse Model of Down Syndrome. Frontiers in Behavioral Neuroscience. 9: 330. PMID 26696850 DOI: 10.3389/Fnbeh.2015.00330 |
0.331 |
|
| 2015 |
Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13843-52. PMID 26468184 DOI: 10.1523/Jneurosci.2775-15.2015 |
0.362 |
|
| 2015 |
de Sola S, de la Torre R, Sánchez-Benavides G, Benejam B, Cuenca-Royo A, Del Hoyo L, Rodríguez J, Catuara-Solarz S, Sanchez-Gutierrez J, Dueñas-Espin I, Hernandez G, Peña-Casanova J, Langohr K, Videla S, Blehaut H, ... ... Dierssen M, et al. A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials. Frontiers in Psychology. 6: 708. PMID 26089807 DOI: 10.3389/Fpsyg.2015.00708 |
0.31 |
|
| 2015 |
Santos M, D'Amico D, Dierssen M. From neural to genetic substrates of panic disorder: Insights from human and mouse studies. European Journal of Pharmacology. 759: 127-41. PMID 25818748 DOI: 10.1016/J.Ejphar.2015.03.039 |
0.334 |
|
| 2015 |
Brault V, Duchon A, Romestaing C, Sahun I, Pothion S, Karout M, Borel C, Dembele D, Bizot JC, Messaddeq N, Sharp AJ, Roussel D, Antonarakis SE, Dierssen M, Hérault Y. Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region. Plos Genetics. 11: e1005062. PMID 25803843 DOI: 10.1371/Journal.Pgen.1005062 |
0.331 |
|
| 2015 |
Weitzdoerfer R, Toran N, Subramaniyan S, Pollak A, Dierssen M, Lubec G. A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain. Amino Acids. 47: 1127-34. PMID 25740605 DOI: 10.1007/S00726-015-1941-1 |
0.362 |
|
| 2015 |
Pujol J, del Hoyo L, Blanco-Hinojo L, de Sola S, Macià D, Martínez-Vilavella G, Amor M, Deus J, Rodríguez J, Farré M, Dierssen M, de la Torre R. Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 64: 148-56. PMID 25461715 DOI: 10.1016/J.Cortex.2014.10.012 |
0.359 |
|
| 2015 |
Ballester-Lurbe B, González-Granero S, Mocholí E, Poch E, García-Manzanares M, Dierssen M, Pérez-Roger I, García-Verdugo JM, Guasch RM, Terrado J. RhoE deficiency alters postnatal subventricular zone development and the number of calbindin-expressing neurons in the olfactory bulb of mouse. Brain Structure & Function. 220: 3113-30. PMID 25009316 DOI: 10.1007/S00429-014-0846-1 |
0.316 |
|
| 2014 |
Molas S, Gener T, Güell J, Martín M, Ballesteros-Yáñez I, Sanchez-Vives MV, Dierssen M. Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice. Acta Neuropathologica Communications. 2: 147. PMID 25384568 DOI: 10.1186/S40478-014-0147-1 |
0.316 |
|
| 2014 |
Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano V. Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Human Molecular Genetics. 23: 6481-94. PMID 25027326 DOI: 10.1093/Hmg/Ddu368 |
0.402 |
|
| 2014 |
Molas S, Dierssen M. The role of nicotinic receptors in shaping and functioning of the glutamatergic system: a window into cognitive pathology. Neuroscience and Biobehavioral Reviews. 46: 315-25. PMID 24879992 DOI: 10.1016/J.Neubiorev.2014.05.012 |
0.32 |
|
| 2014 |
Souchet B, Guedj F, Sahún I, Duchon A, Daubigney F, Badel A, Yanagawa Y, Barallobre MJ, Dierssen M, Yu E, Herault Y, Arbones M, Janel N, Créau N, Delabar JM. Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage. Neurobiology of Disease. 69: 65-75. PMID 24801365 DOI: 10.1016/J.Nbd.2014.04.016 |
0.396 |
|
| 2014 |
Sahún I, Marechal D, Pereira PL, Nalesso V, Gruart A, Garcia JM, Antonarakis SE, Dierssen M, Herault Y. Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome. Genetics. 197: 899-912. PMID 24752061 DOI: 10.1534/Genetics.114.165241 |
0.392 |
|
| 2014 |
Mellström B, Sahún I, Ruiz-Nuño A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higuera-Matas A, Errington ML, Maldonado R, DeFelipe J, ... ... Dierssen M, et al. DREAM controls the on/off switch of specific activity-dependent transcription pathways. Molecular and Cellular Biology. 34: 877-87. PMID 24366545 DOI: 10.1128/Mcb.00360-13 |
0.32 |
|
| 2014 |
Mouton-Liger F, Sahún I, Collin T, Lopes Pereira P, Masini D, Thomas S, Paly E, Luilier S, Même S, Jouhault Q, Bennaï S, Beloeil JC, Bizot JC, Hérault Y, Dierssen M, et al. Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome. Neurobiology of Disease. 63: 92-106. PMID 24291518 DOI: 10.1016/J.Nbd.2013.11.016 |
0.391 |
|
| 2014 |
De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, ... ... Dierssen M, et al. Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans. Molecular Nutrition & Food Research. 58: 278-88. PMID 24039182 DOI: 10.1002/Mnfr.201300325 |
0.355 |
|
| 2014 |
Fillat C, Ros XB, Santos M, Martín ED, Andreu N, Villanueva E, d’Amico D, Dierssen M, Altafaj X. Identification of key genes involved in Down's syndrome pathogenesis by gene therapy International Medical Review On Down Syndrome. 18: 21-28. DOI: 10.1016/S2171-9748(14)70049-2 |
0.343 |
|
| 2013 |
Del Pino I, GarcÃa-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, MartÃnez de Lagrán M, Ciceri G, Gabaldón MV, Moratal D, Dierssen M, Canals S, MarÃn O, Rico B. Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes. Neuron. 79: 1152-68. PMID 24050403 DOI: 10.1016/J.Neuron.2013.07.010 |
0.312 |
|
| 2013 |
Santos M, D'Amico D, Spadoni O, Amador-Arjona A, Stork O, Dierssen M. Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15259-71. PMID 24048855 DOI: 10.1523/Jneurosci.2161-13.2013 |
0.339 |
|
| 2013 |
Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, et al. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain : a Journal of Neurology. 136: 3018-27. PMID 24030951 DOI: 10.1093/Brain/Awt237 |
0.302 |
|
| 2013 |
Carrasco P, Jacas J, Sahún I, Muley H, RamÃrez S, Puisac B, Mezquita P, Pié J, Dierssen M, Casals N. Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behavioural Brain Research. 256: 291-7. PMID 23973755 DOI: 10.1016/J.Bbr.2013.08.004 |
0.345 |
|
| 2013 |
Pons-Espinal M, Martinez de Lagran M, Dierssen M. Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A. Neurobiology of Disease. 60: 18-31. PMID 23969234 DOI: 10.1016/J.Nbd.2013.08.008 |
0.362 |
|
| 2013 |
Stefos GC, Soppa U, Dierssen M, Becker W. NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Plos One. 8: e67470. PMID 23825664 DOI: 10.1371/Journal.Pone.0067470 |
0.327 |
|
| 2013 |
Pons-Espinal M, de Lagran MM, Dierssen M. Functional implications of hippocampal adult neurogenesis in intellectual disabilities. Amino Acids. 45: 113-31. PMID 23604404 DOI: 10.1007/S00726-013-1489-X |
0.315 |
|
| 2013 |
Busquets-Garcia A, Gomis-González M, Guegan T, AgustÃn-Pavón C, Pastor A, Mato S, Pérez-SamartÃn A, Matute C, de la Torre R, Dierssen M, Maldonado R, Ozaita A. Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nature Medicine. 19: 603-7. PMID 23542787 DOI: 10.1038/Nm.3127 |
0.392 |
|
| 2013 |
Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease. 52: 117-27. PMID 23220201 DOI: 10.1016/J.Nbd.2012.11.017 |
0.412 |
|
| 2013 |
Llorente-Folch I, Sahún I, Contreras L, Casarejos MJ, Grau JM, Saheki T, Mena MA, Satrústegui J, Dierssen M, Pardo B. AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway. Journal of Neurochemistry. 124: 347-62. PMID 23216354 DOI: 10.1111/Jnc.12096 |
0.321 |
|
| 2012 |
Dierssen M. Down syndrome: the brain in trisomic mode. Nature Reviews. Neuroscience. 13: 844-58. PMID 23165261 DOI: 10.1038/Nrn3314 |
0.37 |
|
| 2012 |
Garriga-Canut M, Agustín-Pavón C, Herrmann F, Sánchez A, Dierssen M, Fillat C, Isalan M. Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proceedings of the National Academy of Sciences of the United States of America. 109: E3136-45. PMID 23054839 DOI: 10.1073/Pnas.1206506109 |
0.367 |
|
| 2012 |
Dierssen M, Fedrizzi L, Gomez-Villafuertes R, de Lagran MM, Gutierrez-Adan A, Sahún I, Pintado B, Oliveros JC, Dopazo XM, Gonzalez P, Brini M, Mellström B, Carafoli E, Naranjo JR. Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice. Frontiers in Molecular Neuroscience. 5: 58. PMID 22563308 DOI: 10.3389/Fnmol.2012.00058 |
0.323 |
|
| 2012 |
de la Torre R, Dierssen M. Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future. Progress in Brain Research. 197: 1-14. PMID 22541285 DOI: 10.1016/B978-0-444-54299-1.00001-7 |
0.323 |
|
| 2012 |
Carrasco P, Sahún I, McDonald J, RamÃrez S, Jacas J, Gratacós E, Sierra AY, Serra D, Herrero L, Acker-Palmer A, Hegardt FG, Dierssen M, Casals N. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. The Journal of Biological Chemistry. 287: 21224-32. PMID 22539351 DOI: 10.1074/Jbc.M111.337493 |
0.357 |
|
| 2012 |
Mercader JM, González JR, Lozano JJ, Bak M, Kauppinen S, Sumoy L, Dierssen M, Fernández-Aranda F, Visa J, Gratacòs M, Estivill X. Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model. Gene. 497: 181-90. PMID 22310387 DOI: 10.1016/J.Gene.2012.01.057 |
0.33 |
|
| 2012 |
Martinez de Lagran M, Benavides-Piccione R, Ballesteros-Yañez I, Calvo M, Morales M, Fillat C, Defelipe J, Ramakers GJ, Dierssen M. Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons. Cerebral Cortex (New York, N.Y. : 1991). 22: 2867-77. PMID 22215728 DOI: 10.1093/Cercor/Bhr362 |
0.344 |
|
| 2012 |
Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernandez-Montes RD, Gratacòs M, Pumarola M, Cabrera R, Maldonado R, Sabrià J, Estivill X, Dierssen M. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects Amino Acids. 43: 897-909. PMID 22101982 DOI: 10.1007/S00726-011-1149-Y |
0.301 |
|
| 2011 |
Baamonde C, MartÃnez-Cué C, Flórez J, Dierssen M. G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model. Developmental Neuroscience. 33: 442-50. PMID 21865666 DOI: 10.1159/000329425 |
0.403 |
|
| 2011 |
Teixeira CM, MartÃn ED, Sahún I, Masachs N, Pujadas L, Corvelo A, Bosch C, Rossi D, Martinez A, Maldonado R, Dierssen M, Soriano E. Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2395-405. PMID 21814183 DOI: 10.1038/Npp.2011.153 |
0.318 |
|
| 2011 |
Mocholí E, Ballester-Lurbe B, Arqué G, Poch E, Peris B, Guerri C, Dierssen M, Guasch RM, Terrado J, Pérez-Roger I. RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. Plos One. 6: e19236. PMID 21552537 DOI: 10.1371/Journal.Pone.0019236 |
0.365 |
|
| 2011 |
Dierssen M, Arqué G, McDonald J, Andreu N, MartÃnez-Cué C, Flórez J, Fillat C. Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1. Plos One. 6: e17010. PMID 21364922 DOI: 10.1371/Journal.Pone.0017010 |
0.368 |
|
| 2011 |
Sun Y, Dierssen M, Toran N, Pollak DD, Chen WQ, Lubec G. A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain. Journal of Proteomics. 74: 547-57. PMID 21262400 DOI: 10.1016/J.Jprot.2011.01.009 |
0.34 |
|
| 2011 |
Corbin JG, Paluszkiewicz SM, Martin BS, Huntsman MM, Tranfaglia MR, Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE, Chakrabarti L, ... ... Dierssen M, et al. Author and Subject Index Developmental Neuroscience. 33: 468-468. DOI: 10.1159/000334885 |
0.447 |
|
| 2010 |
Gardiner K, Herault Y, Lott IT, Antonarakis SE, Reeves RH, Dierssen M. Down syndrome: from understanding the neurobiology to therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14943-5. PMID 21068296 DOI: 10.1523/Jneurosci.3728-10.2010 |
0.36 |
|
| 2010 |
Santos M, Summavielle T, Teixeira-Castro A, Silva-Fernandes A, Duarte-Silva S, Marques F, Martins L, Dierssen M, Oliveira P, Sousa N, Maciel P. Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome. Neuroscience. 170: 453-467. PMID 20633611 DOI: 10.1016/J.Neuroscience.2010.07.010 |
0.4 |
|
| 2010 |
Toiber D, Azkona G, Ben-Ari S, Torán N, Soreq H, Dierssen M. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiology of Disease. 40: 348-59. PMID 20600907 DOI: 10.1016/J.Nbd.2010.06.011 |
0.383 |
|
| 2010 |
Azkona G, Levannon D, Groner Y, Dierssen M. In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model. Amino Acids. 39: 1571-80. PMID 20596738 DOI: 10.1007/S00726-010-0662-8 |
0.401 |
|
| 2010 |
Fillat C, Dierssen M, de Lagrán MM, Altafaj X. Insights from mouse models to understand neurodegeneration in Down syndrome. Cns & Neurological Disorders Drug Targets. 9: 429-38. PMID 20522013 DOI: 10.2174/187152710791556159 |
0.354 |
|
| 2010 |
Lott IT, Dierssen M. Cognitive deficits and associated neurological complications in individuals with Down's syndrome. The Lancet. Neurology. 9: 623-33. PMID 20494326 DOI: 10.1016/S1474-4422(10)70112-5 |
0.328 |
|
| 2010 |
Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A, Maldonado R, Dierssen M. Increased opioid dependence in a mouse model of panic disorder. Frontiers in Behavioral Neuroscience. 3: 60. PMID 20204153 DOI: 10.3389/Neuro.08.060.2009 |
0.333 |
|
| 2010 |
Botella-López A, Cuchillo-Ibáñez I, Cotrufo T, Mok SS, Li QX, Barquero MS, Dierssen M, Soriano E, Sáez-Valero J. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Neurobiology of Disease. 37: 682-91. PMID 20025970 DOI: 10.1016/J.Nbd.2009.12.006 |
0.326 |
|
| 2010 |
Azkona G, Amador-Arjona A, Obradors-Tarragó C, Varea E, Arqué G, Pinacho R, Fillat C, de la Luna S, Estivill X, Dierssen M. Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2. Genes, Brain, and Behavior. 9: 160-72. PMID 19840121 DOI: 10.1111/J.1601-183X.2009.00538.X |
0.38 |
|
| 2009 |
Pereira PL, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, Gruart A, Bizot JC, Chadefaux-Vekemans B, Deutsch S, Trovero F, Delgado-García JM, Antonarakis SE, Dierssen M, Herault Y. A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Human Molecular Genetics. 18: 4756-69. PMID 19783846 DOI: 10.1093/Hmg/Ddp438 |
0.384 |
|
| 2009 |
Arqué G, de Lagrán MM, Arbonés ML, Dierssen M. Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice. Neurobiology of Disease. 36: 312-9. PMID 19660545 DOI: 10.1016/J.Nbd.2009.07.027 |
0.371 |
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| 2009 |
Giralt A, Rodrigo T, MartÃn ED, Gonzalez JR, Milà M, Ceña V, Dierssen M, Canals JM, Alberch J. Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression. Neuroscience. 158: 1234-50. PMID 19121372 DOI: 10.1016/J.Neuroscience.2008.11.024 |
0.348 |
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| 2008 |
Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C. Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome. American Journal of Human Genetics. 83: 479-88. PMID 18940310 DOI: 10.1016/J.Ajhg.2008.09.010 |
0.404 |
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| 2008 |
Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacòs M, Estivill X. Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiological Genomics. 35: 341-50. PMID 18812457 DOI: 10.1152/Physiolgenomics.90255.2008 |
0.361 |
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| 2008 |
Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J, Andreu N, Dierssen M, González-GarcÃa C, Ceña V, Martà E, Fillat C. Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiology of Disease. 32: 377-84. PMID 18773961 DOI: 10.1016/J.Nbd.2008.07.024 |
0.328 |
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| 2008 |
Arqué G, Fotaki V, Fernández D, Martínez de Lagrán M, Arbonés ML, Dierssen M. Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A). Plos One. 3: e2575. PMID 18648535 DOI: 10.1371/Journal.Pone.0002575 |
0.379 |
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| 2008 |
Pritchard M, Reeves RH, Dierssen M, Patterson D, Gardiner KJ. Down syndrome and the genes of human chromosome 21: Current knowledge and future potentials. Report on the Expert workshop on the biology of chromosome 21 genes: Towards gene-phenotype correlations in Down syndrome. Washington D.C., September 28-October 1, 2007 Cytogenetic and Genome Research. 121: 67-77. PMID 18544929 DOI: 10.1159/000124384 |
0.337 |
|
| 2008 |
Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, Cellini E, de Cid R, Dierssen M, EscaramÃs G, Fernández-Aranda F, Forcano L, Gallego X, González JR, Gorwood P, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Human Molecular Genetics. 17: 1234-44. PMID 18203754 DOI: 10.1016/J.Eurpsy.2008.01.1010 |
0.302 |
|
| 2008 |
Cheon MS, Dierssen M, Kim SH, Lubec G. Protein expression of BACE1, BACE2 and APP in Down syndrome brains Amino Acids. 35: 339-343. PMID 18163181 DOI: 10.1007/S00726-007-0618-9 |
0.354 |
|
| 2007 |
Whittle N, Sartori SB, Dierssen M, Lubec G, Singewald N. Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics. 120: e1465-71. PMID 17998315 DOI: 10.1542/Peds.2006-3448 |
0.337 |
|
| 2007 |
Suelves M, Vidal B, Serrano AL, Tjwa M, Roma J, López-Alemany R, Luttun A, de Lagrán MM, Díaz-Ramos A, Díaz MA, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, et al. uPA deficiency exacerbates muscular dystrophy in MDX mice. The Journal of Cell Biology. 178: 1039-51. PMID 17785520 DOI: 10.1083/jcb.200705127 |
0.31 |
|
| 2007 |
Gratacòs M, Sahún I, Gallego X, Amador-Arjona A, Estivill X, Dierssen M. Candidate genes for panic disorder: insight from human and mouse genetic studies Genes, Brain and Behavior. 6: 2-23. PMID 17543035 DOI: 10.1111/J.1601-183X.2007.00318.X |
0.337 |
|
| 2007 |
Martinez de Lagran M, Bortolozzi A, Millan O, Gispert JD, Gonzalez JR, Arbones ML, Artigas F, Dierssen M. Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-). Genes, Brain, and Behavior. 6: 569-78. PMID 17137466 DOI: 10.1111/J.1601-183X.2006.00285.X |
0.351 |
|
| 2007 |
Sahún I, Gallego X, Gratacòs M, Murtra P, Trullás R, Maldonado R, Estivill X, Dierssen M. Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry. Amino Acids. 33: 677-88. PMID 17111100 DOI: 10.1007/S00726-006-0464-1 |
0.324 |
|
| 2007 |
Dierssen M. Understanding the human brain through mouse models Genes, Brain and Behavior. 6: 1-1. DOI: 10.1111/J.1601-183X.2007.00317.X |
0.302 |
|
| 2006 |
Dierssen M, Lagrán MMd. DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis. The Scientific World Journal. 6: 1911-1922. PMID 17205196 DOI: 10.1100/Tsw.2006.319 |
0.37 |
|
| 2006 |
Dierssen M, Gratacòs M, Sahún I, MartÃn M, Gallego X, Amador-Arjona A, MartÃnez de Lagrán M, Murtra P, Martà E, Pujana MA, Ferrer I, Dalfó E, MartÃnez-Cué C, Flórez J, Torres-Peraza JF, et al. Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction. Neurobiology of Disease. 24: 403-18. PMID 16963267 DOI: 10.1016/J.Nbd.2006.07.015 |
0.349 |
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| 2006 |
Dierssen M, Ramakers GJ. Dendritic pathology in mental retardation: from molecular genetics to neurobiology. Genes, Brain, and Behavior. 5: 48-60. PMID 16681800 DOI: 10.1111/J.1601-183X.2006.00224.X |
0.37 |
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| 2006 |
Lumbreras M, Baamonde C, MartÃnez-Cué C, Lubec G, Cairns N, Sallés J, Dierssen M, Flórez J. Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease. Amino Acids. 31: 449-56. PMID 16583316 DOI: 10.1007/S00726-005-0272-Z |
0.312 |
|
| 2006 |
Dierssen M, Ortiz-Abalia J, Arqué G, de Lagrán MM, Fillat C. Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments. Behavior Genetics. 36: 454-68. PMID 16520905 DOI: 10.1007/S10519-006-9050-2 |
0.327 |
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| 2005 |
Ferrer I, Barrachina M, Puig B, Martínez de Lagrán M, Martí E, Avila J, Dierssen M. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiology of Disease. 20: 392-400. PMID 16242644 DOI: 10.1016/J.Nbd.2005.03.020 |
0.324 |
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| 2005 |
Benavides-Piccione R, Dierssen M, Ballesteros-Yáñez I, Martínez de Lagrán M, Arbonés ML, Fotaki V, DeFelipe J, Elston GN. Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse. Neurobiology of Disease. 20: 115-22. PMID 16137572 DOI: 10.1016/J.Nbd.2005.02.004 |
0.379 |
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| 2004 |
Benavides-Piccione R, Ballesteros-Yáñez I, de Lagrán MM, Elston G, Estivill X, Fillat C, Defelipe J, Dierssen M. On dendrites in Down syndrome and DS murine models: a spiny way to learn. Progress in Neurobiology. 74: 111-26. PMID 15518956 DOI: 10.1016/J.Pneurobio.2004.08.001 |
0.384 |
|
| 2004 |
Kurt MA, Kafa MI, Dierssen M, Davies DC. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Research. 1022: 101-9. PMID 15353219 DOI: 10.1016/J.Brainres.2004.06.075 |
0.306 |
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| 2004 |
Fotaki V, Lagrán MMD, Estivill X, Arbonés M, Dierssen M. Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. Behavioral Neuroscience. 118: 815-821. PMID 15301607 DOI: 10.1037/0735-7044.118.4.815 |
0.347 |
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| 2004 |
Lagrán MMd, Altafaj X, Gallego X, Martı́ E, Estivill X, Sahún I, Fillat C, Dierssen M. Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiology of Disease. 15: 132-142. PMID 14751778 DOI: 10.1016/J.Nbd.2003.10.002 |
0.325 |
|
| 2003 |
Unterberger U, Lubec G, Dierssen M, Stoltenburg-Didinger G, Farreras JC, Budka H. The cerebral cortex in fetal Down syndrome. Journal of Neural Transmission. Supplementum. 159-63. PMID 15068248 DOI: 10.1007/978-3-7091-6721-2_14 |
0.352 |
|
| 2003 |
Dierssen M, Benavides-Piccione R, Martínez-Cué C, Estivill X, Flórez J, Elston GN, DeFelipe J. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cerebral Cortex (New York, N.Y. : 1991). 13: 758-64. PMID 12816891 DOI: 10.1093/Cercor/13.7.758 |
0.587 |
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| 2003 |
Martí E, Altafaj X, Dierssen M, de la Luna S, Fotaki V, Alvarez M, Pérez-Riba M, Ferrer I, Estivill X. Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. Brain Research. 964: 250-63. PMID 12576186 DOI: 10.1016/S0006-8993(02)04069-6 |
0.327 |
|
| 2002 |
Fotaki V, Dierssen M, Alcántara S, MartÃnez S, Martà E, Casas C, Visa J, Soriano E, Estivill X, Arbonés ML. Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Molecular and Cellular Biology. 22: 6636-47. PMID 12192061 DOI: 10.1128/Mcb.22.18.6636-6647.2002 |
0.399 |
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| 2002 |
MartÃnez-Cué C, Baamonde C, Lumbreras M, Paz J, Davisson MT, Schmidt C, Dierssen M, Flórez J. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behavioural Brain Research. 134: 185-200. PMID 12191805 DOI: 10.1016/S0166-4328(02)00026-8 |
0.331 |
|
| 2001 |
Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G. Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure Journal of Neural Transmission-Supplement. 59-70. PMID 11771761 DOI: 10.1007/978-3-7091-6262-0_5 |
0.328 |
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| 2001 |
Engidawork E, Balic N, Fountoulakis M, Dierssen M, Greber-Platzer S, Lubec G. β-Amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect Journal of Neural Transmission-Supplement. 335-46. PMID 11771756 DOI: 10.1007/978-3-7091-6262-0_28 |
0.328 |
|
| 2001 |
Lubec B, Yoo BC, Dierssen M, Balic N, Lubec G. Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation. Journal of Neural Transmission-Supplement. 303-10. PMID 11771753 DOI: 10.1007/978-3-7091-6262-0_25 |
0.307 |
|
| 2001 |
Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. Journal of Neural Transmission. Supplementum. 281-8. PMID 11771751 DOI: 10.1007/978-3-7091-6262-0_23 |
0.313 |
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| 2001 |
Engidawork E, Balic N, Juranville J-, Fountoulakis M, Dierssen M, Lubec G. Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis. Journal of Neural Transmission-Supplement. 149-62. PMID 11771740 DOI: 10.1007/978-3-7091-6262-0_12 |
0.316 |
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| 2001 |
Dierssen M, Martí E, Pucharcós C, Fotaki V, Altafaj X, Casas K, Solans A, Arbonés ML, Fillat C, Estivill X. Functional genomics of Down syndrome: a multidisciplinary approach. Journal of Neural Transmission-Supplement. 131-48. PMID 11771739 DOI: 10.1007/978-3-7091-6262-0_11 |
0.345 |
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| 2001 |
Engidawork E, Juranville J-, Fountoulakis M, Dierssen M, Lubec G. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome Journal of Neural Transmission-Supplement. 117-30. PMID 11771738 DOI: 10.1007/978-3-7091-6262-0_10 |
0.316 |
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| 2001 |
Ruiz de Azúa I, Lumbreras MA, Zalduegui A, Baamonde C, Dierssen M, Flórez J, Sallés J. Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. Journal of Neuroscience Research. 66: 540-50. PMID 11746373 DOI: 10.1002/Jnr.10019 |
0.352 |
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| 2001 |
Dierssen M, Fillat C, Crnic L, Arbonés M, Flórez J, Estivill X. Murine models for Down syndrome. Physiology & Behavior. 73: 859-71. PMID 11566219 DOI: 10.1016/S0031-9384(01)00523-6 |
0.386 |
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| 2001 |
Altafaj X, Dierssen M, Baamonde C, Martà E, Visa J, Guimerà J, Oset M, González JR, Flórez J, Fillat C, Estivill X. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Human Molecular Genetics. 10: 1915-23. PMID 11555628 DOI: 10.1093/Hmg/10.18.1915 |
0.42 |
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| 2000 |
Chrast R, Scott HS, Papasavvas MP, Rossier C, Antonarakis ES, Barras C, Davisson MT, Schmidt C, Estivill X, Dierssen M, Pritchard M, Antonarakis SE. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. Genome Research. 10: 2006-21. PMID 11116095 DOI: 10.1101/Gr.10.12.2006 |
0.375 |
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| 2000 |
Kurt MA, Davies DC, Kidd M, Dierssen M, Flórez J. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Research. 858: 191-7. PMID 10700614 DOI: 10.1016/S0006-8993(00)01984-3 |
0.374 |
|
| 1999 |
Fuentes JJ, Dierssen M, Pucharcós C, Fillat C, Casas C, Estivill X, Pritchard M. Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin. Journal of Neural Transmission-Supplement. 57: 337-352. PMID 10666688 DOI: 10.1007/978-3-7091-6380-1_24 |
0.307 |
|
| 1999 |
Dierssen M, Pritchard M, Fillat C, Arbonés M, Aran JM, Flórez J, Xavier E. Chapter 5.9 Modelling Down syndrome in mice Techniques in the Behavioral and Neural Sciences. 13: 895-913. DOI: 10.1016/S0921-0709(99)80066-2 |
0.392 |
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| 1998 |
Insausti AM, MegÃas M, Crespo D, Cruz-Orive LM, Dierssen M, Vallina IF, Insausti R, Flórez J, Vallina TF. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neuroscience Letters. 253: 175-8. PMID 9792239 DOI: 10.1016/S0304-3940(98)00641-7 |
0.344 |
|
| 1998 |
Escorihuela RM, Vallina IF, MartÃnez-Cué C, Baamonde C, Dierssen M, Tobeña A, Flórez J, Fernández-Teruel A. Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neuroscience Letters. 247: 171-4. PMID 9655620 DOI: 10.1016/S0304-3940(98)00317-6 |
0.351 |
|
| 1997 |
MegÃas M, Verduga R, Dierssen M, Flórez J, Insausti R, Crespo D. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport. 8: 3475-8. PMID 9427310 DOI: 10.1097/00001756-199711100-00012 |
0.386 |
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| 1997 |
Dierssen M, Vallina IF, Baamonde C, GarcÃa-Calatayud S, Lumbreras MA, Flórez J. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Research. 749: 238-44. PMID 9138724 DOI: 10.1016/S0006-8993(96)01173-0 |
0.366 |
|
| 1996 |
Dierssen M, Vallina IF, Baamonde C, Lumbreras MA, MartÃnez-Cué C, Calatayud SG, Flórez J. Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model. Brain Research. Developmental Brain Research. 95: 122-4. PMID 8873983 DOI: 10.1016/0165-3806(96)00071-5 |
0.354 |
|
| 1995 |
Escorihuela RM, Fernández-Teruel A, Vallina IF, Baamonde C, Lumbreras MA, Dierssen M, Tobeña A, Flórez J. A behavioral assessment of Ts65Dn mice: a putative Down syndrome model. Neuroscience Letters. 199: 143-6. PMID 8584244 DOI: 10.1016/0304-3940(95)12052-6 |
0.364 |
|
| 1990 |
Florez J, Dierssen M, Ruiz F, Hurle MA. Influence of Bay K 8644 on the respiratory centers and its interaction with opiate activity European Journal of Pharmacology. 183: 976. DOI: 10.1016/0014-2999(90)92819-5 |
0.461 |
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