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Mara Dierssen - Publications

Affiliations: 
Center for Genomic Regulation (CRG), Spain 
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Year Citation  Score
2020 Roper RJ, Goodlett CR, Martínez de Lagrán M, Dierssen M. Behavioral Phenotyping for Down Syndrome in Mice. Current Protocols in Mouse Biology. 10: e79. PMID 32780566 DOI: 10.1002/Cpmo.79  0.34
2020 Dierssen M, Fructuoso M, Martínez de Lagrán M, Perluigi M, Barone E. Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions. Frontiers in Neuroscience. 14: 670. PMID 32733190 DOI: 10.3389/Fnins.2020.00670  0.338
2020 Fructuoso M, Gu YC, Kassis N, de Lagran MM, Dierssen M, Janel N. Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Molecular Neurobiology. 57: 3195-3205. PMID 32504418 DOI: 10.1007/S12035-020-01967-6  0.319
2020 Alemany-González M, Gener T, Nebot P, Vilademunt M, Dierssen M, Puig MV. Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability. Proceedings of the National Academy of Sciences of the United States of America. 117: 11788-11798. PMID 32393630 DOI: 10.1073/Pnas.1921314117  0.342
2020 Gu Y, Moroy G, Paul JL, Rebillat AS, Dierssen M, de la Torre R, Cieuta-Walti C, Dairou J, Janel N. Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup Dietary Supplement: Role of Green Tea Catechins. International Journal of Molecular Sciences. 21. PMID 32092951 DOI: 10.3390/Ijms21041404  0.367
2020 Martínez Cué C, Dierssen M. Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome. Progress in Brain Research. 251: 269-302. PMID 32057310 DOI: 10.1016/Bs.Pbr.2019.11.001  0.365
2020 Rueda N, Flórez J, Dierssen M, Martínez-Cué C. Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome. Progress in Brain Research. 251: 245-268. PMID 32057309 DOI: 10.1016/Bs.Pbr.2019.10.001  0.581
2019 De Toma I, Ortega M, Aloy P, Sabidó E, Dierssen M. DYRK1A Overexpression Alters Cognition and Neural-Related Proteomic Pathways in the Hippocampus That Are Rescued by Green Tea Extract and/or Environmental Enrichment. Frontiers in Molecular Neuroscience. 12: 272. PMID 31803016 DOI: 10.3389/Fnmol.2019.00272  0.359
2019 Navarro-Romero A, Vázquez-Oliver A, Gomis-González M, Garzón-Montesinos C, Falcón-Moya R, Pastor A, Martín-García E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodríguez-Moreno A, et al. Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome. Neurobiology of Disease. 125: 92-106. PMID 30685352 DOI: 10.1016/J.Nbd.2019.01.014  0.414
2018 Faundez V, De Toma I, Bardoni B, Bartesaghi R, Nizetic D, de la Torre R, Cohen Kadosh R, Herault Y, Dierssen M, Potier MC. Translating molecular advances in Down syndrome and Fragile X syndrome into therapies. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 29887288 DOI: 10.1016/S0924-977X(17)31089-1  0.336
2017 Gómez-Grau M, Albaigès J, Casas J, Auladell C, Dierssen M, Vilageliu L, Grinberg D. New murine Niemann-Pick type C models bearing a pseudoexon-generating mutation recapitulate the main neurobehavioural and molecular features of the disease. Scientific Reports. 7: 41931. PMID 28167839 DOI: 10.1038/Srep41931  0.304
2016 Delabar JM, Allinquant B, Bianchi D, Blumenthal T, Dekker A, Edgin J, O'Bryan J, Dierssen M, Potier MC, Wiseman F, Guedj F, Créau N, Reeves R, Gardiner K, Busciglio J. Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society. Molecular Syndromology. 7: 251-261. PMID 27867340 DOI: 10.1159/000449049  0.334
2016 Del Hoyo L, Xicota L, Langohr K, Sánchez-Benavides G, de Sola S, Cuenca-Royo A, Rodriguez J, Rodríguez-Morató J, Farré M, Dierssen M, de la Torre R. VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome. Frontiers in Behavioral Neuroscience. 10: 193. PMID 27799900 DOI: 10.3389/Fnbeh.2016.00193  0.339
2016 De Toma I, Manubens-Gil L, Ossowski S, Dierssen M. Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders. Neural Plasticity. 2016: 4235898. PMID 27547454 DOI: 10.1155/2016/4235898  0.348
2016 D'Amico D, Gener T, de Lagrán MM, Sanchez-Vives MV, Santos M, Dierssen M. Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27534266 DOI: 10.1038/Npp.2016.154  0.327
2016 de la Torre R, de Sola S, Hernandez G, Farré M, Pujol J, Rodriguez J, Espadaler JM, Langohr K, Cuenca-Royo A, Principe A, Xicota L, Janel N, Catuara-Solarz S, Sanchez-Benavides G, Bléhaut H, ... ... Dierssen M, et al. Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial. The Lancet. Neurology. 15: 801-10. PMID 27302362 DOI: 10.1016/S1474-4422(16)30034-5  0.308
2016 Ruiz-Mejias M, Martinez de Lagran M, Mattia M, Castano-Prat P, Perez-Mendez L, Ciria-Suarez L, Gener T, Sancristobal B, García-Ojalvo J, Gruart A, Delgado-García JM, Sanchez-Vives MV, Dierssen M. Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3648-59. PMID 27030752 DOI: 10.1523/Jneurosci.2517-15.2016  0.353
2015 Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Notredame C, Gonzalez JR, Dierssen M. Principal Component Analysis of the Effects of Environmental Enrichment and (-)-epigallocatechin-3-gallate on Age-Associated Learning Deficits in a Mouse Model of Down Syndrome. Frontiers in Behavioral Neuroscience. 9: 330. PMID 26696850 DOI: 10.3389/Fnbeh.2015.00330  0.331
2015 Bartesaghi R, Haydar TF, Delabar JM, Dierssen M, Martínez-Cué C, Bianchi DW. New Perspectives for the Rescue of Cognitive Disability in Down Syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13843-52. PMID 26468184 DOI: 10.1523/Jneurosci.2775-15.2015  0.362
2015 de Sola S, de la Torre R, Sánchez-Benavides G, Benejam B, Cuenca-Royo A, Del Hoyo L, Rodríguez J, Catuara-Solarz S, Sanchez-Gutierrez J, Dueñas-Espin I, Hernandez G, Peña-Casanova J, Langohr K, Videla S, Blehaut H, ... ... Dierssen M, et al. A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials. Frontiers in Psychology. 6: 708. PMID 26089807 DOI: 10.3389/Fpsyg.2015.00708  0.31
2015 Santos M, D'Amico D, Dierssen M. From neural to genetic substrates of panic disorder: Insights from human and mouse studies. European Journal of Pharmacology. 759: 127-41. PMID 25818748 DOI: 10.1016/J.Ejphar.2015.03.039  0.334
2015 Brault V, Duchon A, Romestaing C, Sahun I, Pothion S, Karout M, Borel C, Dembele D, Bizot JC, Messaddeq N, Sharp AJ, Roussel D, Antonarakis SE, Dierssen M, Hérault Y. Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region. Plos Genetics. 11: e1005062. PMID 25803843 DOI: 10.1371/Journal.Pgen.1005062  0.331
2015 Weitzdoerfer R, Toran N, Subramaniyan S, Pollak A, Dierssen M, Lubec G. A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain. Amino Acids. 47: 1127-34. PMID 25740605 DOI: 10.1007/S00726-015-1941-1  0.362
2015 Pujol J, del Hoyo L, Blanco-Hinojo L, de Sola S, Macià D, Martínez-Vilavella G, Amor M, Deus J, Rodríguez J, Farré M, Dierssen M, de la Torre R. Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 64: 148-56. PMID 25461715 DOI: 10.1016/J.Cortex.2014.10.012  0.359
2015 Ballester-Lurbe B, González-Granero S, Mocholí E, Poch E, García-Manzanares M, Dierssen M, Pérez-Roger I, García-Verdugo JM, Guasch RM, Terrado J. RhoE deficiency alters postnatal subventricular zone development and the number of calbindin-expressing neurons in the olfactory bulb of mouse. Brain Structure & Function. 220: 3113-30. PMID 25009316 DOI: 10.1007/S00429-014-0846-1  0.316
2014 Molas S, Gener T, Güell J, Martín M, Ballesteros-Yáñez I, Sanchez-Vives MV, Dierssen M. Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice. Acta Neuropathologica Communications. 2: 147. PMID 25384568 DOI: 10.1186/S40478-014-0147-1  0.316
2014 Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano V. Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Human Molecular Genetics. 23: 6481-94. PMID 25027326 DOI: 10.1093/Hmg/Ddu368  0.402
2014 Molas S, Dierssen M. The role of nicotinic receptors in shaping and functioning of the glutamatergic system: a window into cognitive pathology. Neuroscience and Biobehavioral Reviews. 46: 315-25. PMID 24879992 DOI: 10.1016/J.Neubiorev.2014.05.012  0.32
2014 Souchet B, Guedj F, Sahún I, Duchon A, Daubigney F, Badel A, Yanagawa Y, Barallobre MJ, Dierssen M, Yu E, Herault Y, Arbones M, Janel N, Créau N, Delabar JM. Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage. Neurobiology of Disease. 69: 65-75. PMID 24801365 DOI: 10.1016/J.Nbd.2014.04.016  0.396
2014 Sahún I, Marechal D, Pereira PL, Nalesso V, Gruart A, Garcia JM, Antonarakis SE, Dierssen M, Herault Y. Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome. Genetics. 197: 899-912. PMID 24752061 DOI: 10.1534/Genetics.114.165241  0.392
2014 Mellström B, Sahún I, Ruiz-Nuño A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higuera-Matas A, Errington ML, Maldonado R, DeFelipe J, ... ... Dierssen M, et al. DREAM controls the on/off switch of specific activity-dependent transcription pathways. Molecular and Cellular Biology. 34: 877-87. PMID 24366545 DOI: 10.1128/Mcb.00360-13  0.32
2014 Mouton-Liger F, Sahún I, Collin T, Lopes Pereira P, Masini D, Thomas S, Paly E, Luilier S, Même S, Jouhault Q, Bennaï S, Beloeil JC, Bizot JC, Hérault Y, Dierssen M, et al. Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome. Neurobiology of Disease. 63: 92-106. PMID 24291518 DOI: 10.1016/J.Nbd.2013.11.016  0.391
2014 De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, ... ... Dierssen M, et al. Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans. Molecular Nutrition & Food Research. 58: 278-88. PMID 24039182 DOI: 10.1002/Mnfr.201300325  0.355
2014 Fillat C, Ros XB, Santos M, Martín ED, Andreu N, Villanueva E, d’Amico D, Dierssen M, Altafaj X. Identification of key genes involved in Down's syndrome pathogenesis by gene therapy International Medical Review On Down Syndrome. 18: 21-28. DOI: 10.1016/S2171-9748(14)70049-2  0.343
2013 Del Pino I, García-Frigola C, Dehorter N, Brotons-Mas JR, Alvarez-Salvado E, Martínez de Lagrán M, Ciceri G, Gabaldón MV, Moratal D, Dierssen M, Canals S, Marín O, Rico B. Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes. Neuron. 79: 1152-68. PMID 24050403 DOI: 10.1016/J.Neuron.2013.07.010  0.312
2013 Santos M, D'Amico D, Spadoni O, Amador-Arjona A, Stork O, Dierssen M. Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15259-71. PMID 24048855 DOI: 10.1523/Jneurosci.2161-13.2013  0.339
2013 Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, et al. DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain : a Journal of Neurology. 136: 3018-27. PMID 24030951 DOI: 10.1093/Brain/Awt237  0.302
2013 Carrasco P, Jacas J, Sahún I, Muley H, Ramírez S, Puisac B, Mezquita P, Pié J, Dierssen M, Casals N. Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behavioural Brain Research. 256: 291-7. PMID 23973755 DOI: 10.1016/J.Bbr.2013.08.004  0.345
2013 Pons-Espinal M, Martinez de Lagran M, Dierssen M. Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A. Neurobiology of Disease. 60: 18-31. PMID 23969234 DOI: 10.1016/J.Nbd.2013.08.008  0.362
2013 Stefos GC, Soppa U, Dierssen M, Becker W. NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. Plos One. 8: e67470. PMID 23825664 DOI: 10.1371/Journal.Pone.0067470  0.327
2013 Pons-Espinal M, de Lagran MM, Dierssen M. Functional implications of hippocampal adult neurogenesis in intellectual disabilities. Amino Acids. 45: 113-31. PMID 23604404 DOI: 10.1007/S00726-013-1489-X  0.315
2013 Busquets-Garcia A, Gomis-González M, Guegan T, Agustín-Pavón C, Pastor A, Mato S, Pérez-Samartín A, Matute C, de la Torre R, Dierssen M, Maldonado R, Ozaita A. Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nature Medicine. 19: 603-7. PMID 23542787 DOI: 10.1038/Nm.3127  0.392
2013 Altafaj X, Martín ED, Ortiz-Abalia J, Valderrama A, Lao-Peregrín C, Dierssen M, Fillat C. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease. 52: 117-27. PMID 23220201 DOI: 10.1016/J.Nbd.2012.11.017  0.412
2013 Llorente-Folch I, Sahún I, Contreras L, Casarejos MJ, Grau JM, Saheki T, Mena MA, Satrústegui J, Dierssen M, Pardo B. AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway. Journal of Neurochemistry. 124: 347-62. PMID 23216354 DOI: 10.1111/Jnc.12096  0.321
2012 Dierssen M. Down syndrome: the brain in trisomic mode. Nature Reviews. Neuroscience. 13: 844-58. PMID 23165261 DOI: 10.1038/Nrn3314  0.37
2012 Garriga-Canut M, Agustín-Pavón C, Herrmann F, Sánchez A, Dierssen M, Fillat C, Isalan M. Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proceedings of the National Academy of Sciences of the United States of America. 109: E3136-45. PMID 23054839 DOI: 10.1073/Pnas.1206506109  0.367
2012 Dierssen M, Fedrizzi L, Gomez-Villafuertes R, de Lagran MM, Gutierrez-Adan A, Sahún I, Pintado B, Oliveros JC, Dopazo XM, Gonzalez P, Brini M, Mellström B, Carafoli E, Naranjo JR. Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice. Frontiers in Molecular Neuroscience. 5: 58. PMID 22563308 DOI: 10.3389/Fnmol.2012.00058  0.323
2012 de la Torre R, Dierssen M. Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future. Progress in Brain Research. 197: 1-14. PMID 22541285 DOI: 10.1016/B978-0-444-54299-1.00001-7  0.323
2012 Carrasco P, Sahún I, McDonald J, Ramírez S, Jacas J, Gratacós E, Sierra AY, Serra D, Herrero L, Acker-Palmer A, Hegardt FG, Dierssen M, Casals N. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. The Journal of Biological Chemistry. 287: 21224-32. PMID 22539351 DOI: 10.1074/Jbc.M111.337493  0.357
2012 Mercader JM, González JR, Lozano JJ, Bak M, Kauppinen S, Sumoy L, Dierssen M, Fernández-Aranda F, Visa J, Gratacòs M, Estivill X. Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model. Gene. 497: 181-90. PMID 22310387 DOI: 10.1016/J.Gene.2012.01.057  0.33
2012 Martinez de Lagran M, Benavides-Piccione R, Ballesteros-Yañez I, Calvo M, Morales M, Fillat C, Defelipe J, Ramakers GJ, Dierssen M. Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons. Cerebral Cortex (New York, N.Y. : 1991). 22: 2867-77. PMID 22215728 DOI: 10.1093/Cercor/Bhr362  0.344
2012 Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernandez-Montes RD, Gratacòs M, Pumarola M, Cabrera R, Maldonado R, Sabrià J, Estivill X, Dierssen M. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects Amino Acids. 43: 897-909. PMID 22101982 DOI: 10.1007/S00726-011-1149-Y  0.301
2011 Baamonde C, Martínez-Cué C, Flórez J, Dierssen M. G-protein-associated signal transduction processes are restored after postweaning environmental enrichment in Ts65Dn, a Down syndrome mouse model. Developmental Neuroscience. 33: 442-50. PMID 21865666 DOI: 10.1159/000329425  0.403
2011 Teixeira CM, Martín ED, Sahún I, Masachs N, Pujadas L, Corvelo A, Bosch C, Rossi D, Martinez A, Maldonado R, Dierssen M, Soriano E. Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2395-405. PMID 21814183 DOI: 10.1038/Npp.2011.153  0.318
2011 Mocholí E, Ballester-Lurbe B, Arqué G, Poch E, Peris B, Guerri C, Dierssen M, Guasch RM, Terrado J, Pérez-Roger I. RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. Plos One. 6: e19236. PMID 21552537 DOI: 10.1371/Journal.Pone.0019236  0.365
2011 Dierssen M, Arqué G, McDonald J, Andreu N, Martínez-Cué C, Flórez J, Fillat C. Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1. Plos One. 6: e17010. PMID 21364922 DOI: 10.1371/Journal.Pone.0017010  0.368
2011 Sun Y, Dierssen M, Toran N, Pollak DD, Chen WQ, Lubec G. A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain. Journal of Proteomics. 74: 547-57. PMID 21262400 DOI: 10.1016/J.Jprot.2011.01.009  0.34
2011 Corbin JG, Paluszkiewicz SM, Martin BS, Huntsman MM, Tranfaglia MR, Liu C, Belichenko PV, Zhang L, Fu D, Kleschevnikov AM, Baldini A, Antonarakis SE, Mobley WC, Yu YE, Chakrabarti L, ... ... Dierssen M, et al. Author and Subject Index Developmental Neuroscience. 33: 468-468. DOI: 10.1159/000334885  0.447
2010 Gardiner K, Herault Y, Lott IT, Antonarakis SE, Reeves RH, Dierssen M. Down syndrome: from understanding the neurobiology to therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14943-5. PMID 21068296 DOI: 10.1523/Jneurosci.3728-10.2010  0.36
2010 Santos M, Summavielle T, Teixeira-Castro A, Silva-Fernandes A, Duarte-Silva S, Marques F, Martins L, Dierssen M, Oliveira P, Sousa N, Maciel P. Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome. Neuroscience. 170: 453-467. PMID 20633611 DOI: 10.1016/J.Neuroscience.2010.07.010  0.4
2010 Toiber D, Azkona G, Ben-Ari S, Torán N, Soreq H, Dierssen M. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiology of Disease. 40: 348-59. PMID 20600907 DOI: 10.1016/J.Nbd.2010.06.011  0.383
2010 Azkona G, Levannon D, Groner Y, Dierssen M. In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model. Amino Acids. 39: 1571-80. PMID 20596738 DOI: 10.1007/S00726-010-0662-8  0.401
2010 Fillat C, Dierssen M, de Lagrán MM, Altafaj X. Insights from mouse models to understand neurodegeneration in Down syndrome. Cns & Neurological Disorders Drug Targets. 9: 429-38. PMID 20522013 DOI: 10.2174/187152710791556159  0.354
2010 Lott IT, Dierssen M. Cognitive deficits and associated neurological complications in individuals with Down's syndrome. The Lancet. Neurology. 9: 623-33. PMID 20494326 DOI: 10.1016/S1474-4422(10)70112-5  0.328
2010 Gallego X, Murtra P, Zamalloa T, Canals JM, Pineda J, Amador-Arjona A, Maldonado R, Dierssen M. Increased opioid dependence in a mouse model of panic disorder. Frontiers in Behavioral Neuroscience. 3: 60. PMID 20204153 DOI: 10.3389/Neuro.08.060.2009  0.333
2010 Botella-López A, Cuchillo-Ibáñez I, Cotrufo T, Mok SS, Li QX, Barquero MS, Dierssen M, Soriano E, Sáez-Valero J. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Neurobiology of Disease. 37: 682-91. PMID 20025970 DOI: 10.1016/J.Nbd.2009.12.006  0.326
2010 Azkona G, Amador-Arjona A, Obradors-Tarragó C, Varea E, Arqué G, Pinacho R, Fillat C, de la Luna S, Estivill X, Dierssen M. Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2. Genes, Brain, and Behavior. 9: 160-72. PMID 19840121 DOI: 10.1111/J.1601-183X.2009.00538.X  0.38
2009 Pereira PL, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, Gruart A, Bizot JC, Chadefaux-Vekemans B, Deutsch S, Trovero F, Delgado-García JM, Antonarakis SE, Dierssen M, Herault Y. A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Human Molecular Genetics. 18: 4756-69. PMID 19783846 DOI: 10.1093/Hmg/Ddp438  0.384
2009 Arqué G, de Lagrán MM, Arbonés ML, Dierssen M. Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice. Neurobiology of Disease. 36: 312-9. PMID 19660545 DOI: 10.1016/J.Nbd.2009.07.027  0.371
2009 Giralt A, Rodrigo T, Martín ED, Gonzalez JR, Milà M, Ceña V, Dierssen M, Canals JM, Alberch J. Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression. Neuroscience. 158: 1234-50. PMID 19121372 DOI: 10.1016/J.Neuroscience.2008.11.024  0.348
2008 Ortiz-Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, Fillat C. Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome. American Journal of Human Genetics. 83: 479-88. PMID 18940310 DOI: 10.1016/J.Ajhg.2008.09.010  0.404
2008 Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacòs M, Estivill X. Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiological Genomics. 35: 341-50. PMID 18812457 DOI: 10.1152/Physiolgenomics.90255.2008  0.361
2008 Altafaj X, Ortiz-Abalia J, Fernández M, Potier MC, Laffaire J, Andreu N, Dierssen M, González-García C, Ceña V, Martí E, Fillat C. Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiology of Disease. 32: 377-84. PMID 18773961 DOI: 10.1016/J.Nbd.2008.07.024  0.328
2008 Arqué G, Fotaki V, Fernández D, Martínez de Lagrán M, Arbonés ML, Dierssen M. Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A). Plos One. 3: e2575. PMID 18648535 DOI: 10.1371/Journal.Pone.0002575  0.379
2008 Pritchard M, Reeves RH, Dierssen M, Patterson D, Gardiner KJ. Down syndrome and the genes of human chromosome 21: Current knowledge and future potentials. Report on the Expert workshop on the biology of chromosome 21 genes: Towards gene-phenotype correlations in Down syndrome. Washington D.C., September 28-October 1, 2007 Cytogenetic and Genome Research. 121: 67-77. PMID 18544929 DOI: 10.1159/000124384  0.337
2008 Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, Cellini E, de Cid R, Dierssen M, Escaramís G, Fernández-Aranda F, Forcano L, Gallego X, González JR, Gorwood P, et al. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Human Molecular Genetics. 17: 1234-44. PMID 18203754 DOI: 10.1016/J.Eurpsy.2008.01.1010  0.302
2008 Cheon MS, Dierssen M, Kim SH, Lubec G. Protein expression of BACE1, BACE2 and APP in Down syndrome brains Amino Acids. 35: 339-343. PMID 18163181 DOI: 10.1007/S00726-007-0618-9  0.354
2007 Whittle N, Sartori SB, Dierssen M, Lubec G, Singewald N. Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics. 120: e1465-71. PMID 17998315 DOI: 10.1542/Peds.2006-3448  0.337
2007 Suelves M, Vidal B, Serrano AL, Tjwa M, Roma J, López-Alemany R, Luttun A, de Lagrán MM, Díaz-Ramos A, Díaz MA, Jardí M, Roig M, Dierssen M, Dewerchin M, Carmeliet P, et al. uPA deficiency exacerbates muscular dystrophy in MDX mice. The Journal of Cell Biology. 178: 1039-51. PMID 17785520 DOI: 10.1083/jcb.200705127  0.31
2007 Gratacòs M, Sahún I, Gallego X, Amador-Arjona A, Estivill X, Dierssen M. Candidate genes for panic disorder: insight from human and mouse genetic studies Genes, Brain and Behavior. 6: 2-23. PMID 17543035 DOI: 10.1111/J.1601-183X.2007.00318.X  0.337
2007 Martinez de Lagran M, Bortolozzi A, Millan O, Gispert JD, Gonzalez JR, Arbones ML, Artigas F, Dierssen M. Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-). Genes, Brain, and Behavior. 6: 569-78. PMID 17137466 DOI: 10.1111/J.1601-183X.2006.00285.X  0.351
2007 Sahún I, Gallego X, Gratacòs M, Murtra P, Trullás R, Maldonado R, Estivill X, Dierssen M. Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry. Amino Acids. 33: 677-88. PMID 17111100 DOI: 10.1007/S00726-006-0464-1  0.324
2007 Dierssen M. Understanding the human brain through mouse models Genes, Brain and Behavior. 6: 1-1. DOI: 10.1111/J.1601-183X.2007.00317.X  0.302
2006 Dierssen M, Lagrán MMd. DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis. The Scientific World Journal. 6: 1911-1922. PMID 17205196 DOI: 10.1100/Tsw.2006.319  0.37
2006 Dierssen M, Gratacòs M, Sahún I, Martín M, Gallego X, Amador-Arjona A, Martínez de Lagrán M, Murtra P, Martí E, Pujana MA, Ferrer I, Dalfó E, Martínez-Cué C, Flórez J, Torres-Peraza JF, et al. Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction. Neurobiology of Disease. 24: 403-18. PMID 16963267 DOI: 10.1016/J.Nbd.2006.07.015  0.349
2006 Dierssen M, Ramakers GJ. Dendritic pathology in mental retardation: from molecular genetics to neurobiology. Genes, Brain, and Behavior. 5: 48-60. PMID 16681800 DOI: 10.1111/J.1601-183X.2006.00224.X  0.37
2006 Lumbreras M, Baamonde C, Martínez-Cué C, Lubec G, Cairns N, Sallés J, Dierssen M, Flórez J. Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease. Amino Acids. 31: 449-56. PMID 16583316 DOI: 10.1007/S00726-005-0272-Z  0.312
2006 Dierssen M, Ortiz-Abalia J, Arqué G, de Lagrán MM, Fillat C. Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments. Behavior Genetics. 36: 454-68. PMID 16520905 DOI: 10.1007/S10519-006-9050-2  0.327
2005 Ferrer I, Barrachina M, Puig B, Martínez de Lagrán M, Martí E, Avila J, Dierssen M. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiology of Disease. 20: 392-400. PMID 16242644 DOI: 10.1016/J.Nbd.2005.03.020  0.324
2005 Benavides-Piccione R, Dierssen M, Ballesteros-Yáñez I, Martínez de Lagrán M, Arbonés ML, Fotaki V, DeFelipe J, Elston GN. Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse. Neurobiology of Disease. 20: 115-22. PMID 16137572 DOI: 10.1016/J.Nbd.2005.02.004  0.379
2004 Benavides-Piccione R, Ballesteros-Yáñez I, de Lagrán MM, Elston G, Estivill X, Fillat C, Defelipe J, Dierssen M. On dendrites in Down syndrome and DS murine models: a spiny way to learn. Progress in Neurobiology. 74: 111-26. PMID 15518956 DOI: 10.1016/J.Pneurobio.2004.08.001  0.384
2004 Kurt MA, Kafa MI, Dierssen M, Davies DC. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Research. 1022: 101-9. PMID 15353219 DOI: 10.1016/J.Brainres.2004.06.075  0.306
2004 Fotaki V, Lagrán MMD, Estivill X, Arbonés M, Dierssen M. Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. Behavioral Neuroscience. 118: 815-821. PMID 15301607 DOI: 10.1037/0735-7044.118.4.815  0.347
2004 Lagrán MMd, Altafaj X, Gallego X, Martı́ E, Estivill X, Sahún I, Fillat C, Dierssen M. Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiology of Disease. 15: 132-142. PMID 14751778 DOI: 10.1016/J.Nbd.2003.10.002  0.325
2003 Unterberger U, Lubec G, Dierssen M, Stoltenburg-Didinger G, Farreras JC, Budka H. The cerebral cortex in fetal Down syndrome. Journal of Neural Transmission. Supplementum. 159-63. PMID 15068248 DOI: 10.1007/978-3-7091-6721-2_14  0.352
2003 Dierssen M, Benavides-Piccione R, Martínez-Cué C, Estivill X, Flórez J, Elston GN, DeFelipe J. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cerebral Cortex (New York, N.Y. : 1991). 13: 758-64. PMID 12816891 DOI: 10.1093/Cercor/13.7.758  0.587
2003 Martí E, Altafaj X, Dierssen M, de la Luna S, Fotaki V, Alvarez M, Pérez-Riba M, Ferrer I, Estivill X. Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. Brain Research. 964: 250-63. PMID 12576186 DOI: 10.1016/S0006-8993(02)04069-6  0.327
2002 Fotaki V, Dierssen M, Alcántara S, Martínez S, Martí E, Casas C, Visa J, Soriano E, Estivill X, Arbonés ML. Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Molecular and Cellular Biology. 22: 6636-47. PMID 12192061 DOI: 10.1128/Mcb.22.18.6636-6647.2002  0.399
2002 Martínez-Cué C, Baamonde C, Lumbreras M, Paz J, Davisson MT, Schmidt C, Dierssen M, Flórez J. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behavioural Brain Research. 134: 185-200. PMID 12191805 DOI: 10.1016/S0166-4328(02)00026-8  0.331
2001 Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G. Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure Journal of Neural Transmission-Supplement. 59-70. PMID 11771761 DOI: 10.1007/978-3-7091-6262-0_5  0.328
2001 Engidawork E, Balic N, Fountoulakis M, Dierssen M, Greber-Platzer S, Lubec G. β-Amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect Journal of Neural Transmission-Supplement. 335-46. PMID 11771756 DOI: 10.1007/978-3-7091-6262-0_28  0.328
2001 Lubec B, Yoo BC, Dierssen M, Balic N, Lubec G. Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation. Journal of Neural Transmission-Supplement. 303-10. PMID 11771753 DOI: 10.1007/978-3-7091-6262-0_25  0.307
2001 Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G. Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. Journal of Neural Transmission. Supplementum. 281-8. PMID 11771751 DOI: 10.1007/978-3-7091-6262-0_23  0.313
2001 Engidawork E, Balic N, Juranville J-, Fountoulakis M, Dierssen M, Lubec G. Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis. Journal of Neural Transmission-Supplement. 149-62. PMID 11771740 DOI: 10.1007/978-3-7091-6262-0_12  0.316
2001 Dierssen M, Martí E, Pucharcós C, Fotaki V, Altafaj X, Casas K, Solans A, Arbonés ML, Fillat C, Estivill X. Functional genomics of Down syndrome: a multidisciplinary approach. Journal of Neural Transmission-Supplement. 131-48. PMID 11771739 DOI: 10.1007/978-3-7091-6262-0_11  0.345
2001 Engidawork E, Juranville J-, Fountoulakis M, Dierssen M, Lubec G. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome Journal of Neural Transmission-Supplement. 117-30. PMID 11771738 DOI: 10.1007/978-3-7091-6262-0_10  0.316
2001 Ruiz de Azúa I, Lumbreras MA, Zalduegui A, Baamonde C, Dierssen M, Flórez J, Sallés J. Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. Journal of Neuroscience Research. 66: 540-50. PMID 11746373 DOI: 10.1002/Jnr.10019  0.352
2001 Dierssen M, Fillat C, Crnic L, Arbonés M, Flórez J, Estivill X. Murine models for Down syndrome. Physiology & Behavior. 73: 859-71. PMID 11566219 DOI: 10.1016/S0031-9384(01)00523-6  0.386
2001 Altafaj X, Dierssen M, Baamonde C, Martí E, Visa J, Guimerà J, Oset M, González JR, Flórez J, Fillat C, Estivill X. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Human Molecular Genetics. 10: 1915-23. PMID 11555628 DOI: 10.1093/Hmg/10.18.1915  0.42
2000 Chrast R, Scott HS, Papasavvas MP, Rossier C, Antonarakis ES, Barras C, Davisson MT, Schmidt C, Estivill X, Dierssen M, Pritchard M, Antonarakis SE. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. Genome Research. 10: 2006-21. PMID 11116095 DOI: 10.1101/Gr.10.12.2006  0.375
2000 Kurt MA, Davies DC, Kidd M, Dierssen M, Flórez J. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Research. 858: 191-7. PMID 10700614 DOI: 10.1016/S0006-8993(00)01984-3  0.374
1999 Fuentes JJ, Dierssen M, Pucharcós C, Fillat C, Casas C, Estivill X, Pritchard M. Application of Alu-splice PCR on chromosome 21: DSCR1 and Intersectin. Journal of Neural Transmission-Supplement. 57: 337-352. PMID 10666688 DOI: 10.1007/978-3-7091-6380-1_24  0.307
1999 Dierssen M, Pritchard M, Fillat C, Arbonés M, Aran JM, Flórez J, Xavier E. Chapter 5.9 Modelling Down syndrome in mice Techniques in the Behavioral and Neural Sciences. 13: 895-913. DOI: 10.1016/S0921-0709(99)80066-2  0.392
1998 Insausti AM, Megías M, Crespo D, Cruz-Orive LM, Dierssen M, Vallina IF, Insausti R, Flórez J, Vallina TF. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neuroscience Letters. 253: 175-8. PMID 9792239 DOI: 10.1016/S0304-3940(98)00641-7  0.344
1998 Escorihuela RM, Vallina IF, Martínez-Cué C, Baamonde C, Dierssen M, Tobeña A, Flórez J, Fernández-Teruel A. Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neuroscience Letters. 247: 171-4. PMID 9655620 DOI: 10.1016/S0304-3940(98)00317-6  0.351
1997 Megías M, Verduga R, Dierssen M, Flórez J, Insausti R, Crespo D. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport. 8: 3475-8. PMID 9427310 DOI: 10.1097/00001756-199711100-00012  0.386
1997 Dierssen M, Vallina IF, Baamonde C, García-Calatayud S, Lumbreras MA, Flórez J. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Research. 749: 238-44. PMID 9138724 DOI: 10.1016/S0006-8993(96)01173-0  0.366
1996 Dierssen M, Vallina IF, Baamonde C, Lumbreras MA, Martínez-Cué C, Calatayud SG, Flórez J. Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model. Brain Research. Developmental Brain Research. 95: 122-4. PMID 8873983 DOI: 10.1016/0165-3806(96)00071-5  0.354
1995 Escorihuela RM, Fernández-Teruel A, Vallina IF, Baamonde C, Lumbreras MA, Dierssen M, Tobeña A, Flórez J. A behavioral assessment of Ts65Dn mice: a putative Down syndrome model. Neuroscience Letters. 199: 143-6. PMID 8584244 DOI: 10.1016/0304-3940(95)12052-6  0.364
1990 Florez J, Dierssen M, Ruiz F, Hurle MA. Influence of Bay K 8644 on the respiratory centers and its interaction with opiate activity European Journal of Pharmacology. 183: 976. DOI: 10.1016/0014-2999(90)92819-5  0.461
Low-probability matches (unlikely to be authored by this person)
2002 Dierssen M, Fotaki V, Lagrán MMd, Gratacós M, Arbonés M, Fillat C, Estivill X. Neurobehavioral development of two mouse lines commonly used in transgenic studies. Pharmacology, Biochemistry and Behavior. 73: 19-25. PMID 12076721 DOI: 10.1016/S0091-3057(02)00792-X  0.299
2010 Amador-Arjona A, Delgado-Morales R, Belda X, Gagliano H, Gallego X, Keck ME, Armario A, Dierssen M. Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder. Journal of Psychiatric Research. 44: 157-67. PMID 19698958 DOI: 10.1016/J.Jpsychires.2009.07.008  0.299
2001 Kim SH, Fountoulakis M, Dierssen M, Lubec G. Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains. Journal of Neural Transmission-Supplement. 109-16. PMID 11771736 DOI: 10.1007/978-3-7091-6262-0_9  0.299
2022 Ortega M, De Toma I, Fernández-Blanco Á, Calderón A, Barahona L, Trullàs R, Sabidó E, Dierssen M. Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene. Frontiers in Molecular Neuroscience. 15: 1015220. PMID 36590914 DOI: 10.3389/fnmol.2022.1015220  0.299
2017 Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome. Free Radical Biology & Medicine. PMID 28958596 DOI: 10.1016/J.Freeradbiomed.2017.09.021  0.298
2001 Cheon MS, Fountoulakis M, Dierssen M, Ferreres JC, Lubec G. Expression profiles of proteins in fetal brain with Down syndrome Journal of Neural Transmission, Supplement. 311-319. PMID 11771754 DOI: 10.1007/978-3-7091-6262-0_26  0.297
2001 Yoo BC, Fountoulakis M, Dierssen M, Lubec G. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. Journal of Neural Transmission-Supplement. 321-34. PMID 11771755 DOI: 10.1007/978-3-7091-6262-0_27  0.296
2007 Sahún I, Delgado-García JM, Amador-Arjona A, Giralt A, Alberch J, Dierssen M, Gruart A. Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2253-60. PMID 17329422 DOI: 10.1523/Jneurosci.4055-06.2007  0.295
2002 Fountoulakis M, Juranville JF, Dierssen M, Lubec G. Proteomic analysis of the fetal brain. Proteomics. 2: 1547-76. PMID 12442255 DOI: 10.1002/1615-9861(200211)2:11<1547::Aid-Prot1547>3.0.Co;2-M  0.295
2013 Arque G, Casanovas A, Dierssen M. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome. Plos One. 8: e54285. PMID 23342120 DOI: 10.1371/Journal.Pone.0054285  0.295
1995 Escorihuela RM, Fernandezteruel A, Tobena A, Vivas NM, Marmol F, Badia A, Dierssen M. Early Environmental Stimulation Produces Long-Lasting Changes on β-Adrenoceptor Transduction System Neurobiology of Learning and Memory. 64: 49-57. PMID 7582812 DOI: 10.1006/Nlme.1995.1043  0.293
2012 Viñals X, Molas S, Gallego X, Fernández-Montes RD, Robledo P, Dierssen M, Maldonado R. Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior. Drug and Alcohol Dependence. 122: 247-52. PMID 22024278 DOI: 10.1016/J.Drugalcdep.2011.09.027  0.292
2016 Falsafi SK, Dierssen M, Ghafari M, Pollak A, Lubec G. Reduced cortical neurotransmitter receptor complex levels in fetal Down syndrome brain. Amino Acids. 48: 103-16. PMID 26269195 DOI: 10.1007/S00726-015-2062-6  0.291
2017 Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A. Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. Aging Cell. 16: 1404-1413. PMID 28984064 DOI: 10.1111/Acel.12682  0.289
1991 Dierssen M, Màrmol F, Vivas NM, Clos MV, Gascón S, Badia A. Acute effects of tetrahydroaminoacridine on β-adrenoceptor-linked cyclic AMP accumulation in brain of young and middle-aged rats Neuroscience Letters. 132: 51-54. PMID 1724070 DOI: 10.1016/0304-3940(91)90431-R  0.286
2013 Dierssen M. A commentary on: Overexpression of Dyrk1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome. Experimental Neurology. 247: 110-2. PMID 23570900 DOI: 10.1016/J.Expneurol.2013.03.024  0.285
1995 Vivas NM, Màrmol F, Sallés J, Badia A, Dierssen M. Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine Neuropharmacology. 34: 367-375. PMID 7566467 DOI: 10.1016/0028-3908(95)00003-O  0.285
2012 Gallego X, Ruiz-Medina J, Valverde O, Molas S, Robles N, Sabrià J, Crabbe JC, Dierssen M. Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol (Fayetteville, N.Y.). 46: 205-15. PMID 22459873 DOI: 10.1016/J.Alcohol.2011.11.005  0.284
2001 Kim SH, Dierssen M, Ferreres JC, Fountoulakis M, Lubec G. Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains. Journal of Neural Transmission-Supplement. 273-80. PMID 11771750 DOI: 10.1007/978-3-7091-6262-0_22  0.282
2019 de la Torre R, de Sola S, Farré M, Xicota L, Cuenca-Royo A, Rodriguez J, León A, Langohr K, Gomis-González M, Hernandez G, Esteba S, Del Hoyo L, Sánchez-Gutiérrez J, Cortés MJ, Ozaita A, ... ... Dierssen M, et al. A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome. Clinical Nutrition (Edinburgh, Scotland). PMID 30962103 DOI: 10.1016/J.Clnu.2019.02.028  0.281
2020 Domingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B, Martín-García E, et al. A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature Communications. 11: 782. PMID 32034128 DOI: 10.1038/S41467-020-14458-Y  0.281
2017 Fenoll R, Pujol J, Esteba-Castillo S, de Sola S, Ribas-Vidal N, García-Alba J, Sánchez-Benavides G, Martínez-Vilavella G, Deus J, Dierssen M, Novell-Alsina R, de la Torre R. Anomalous White Matter Structure and the Effect of Age in Down Syndrome Patients. Journal of Alzheimer's Disease : Jad. PMID 28222523 DOI: 10.3233/Jad-161112  0.281
2017 Burokas A, Martín-García E, Espinosa-Carrasco J, Erb I, McDonald J, Notredame C, Dierssen M, Maldonado R. Extinction and reinstatement of an operant responding maintained by food in different models of obesity. Addiction Biology. PMID 29282813 DOI: 10.1111/Adb.12597  0.279
2023 Dierssen M, Sierra C, Sabariego M, Fernández-Blanco A, Cruciani S, Zamora-Moratalla A, Novoa EM. The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity and memory deficits in Down syndrome. Research Square. PMID 37841843 DOI: 10.21203/rs.3.rs-3184329/v1  0.278
2015 Hoyo LD, Xicota L, Sánchez-Benavides G, Cuenca-Royo A, de Sola S, Langohr K, Fagundo AB, Farré M, Dierssen M, de la Torre R. Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults. Frontiers in Behavioral Neuroscience. 9: 301. PMID 26635555 DOI: 10.3389/Fnbeh.2015.00301  0.278
2016 Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R, Schultz MD, Ansoleaga B, Garcia-Esparcia P, Pons-Espinal M, de Lagran MM, Dopazo J, Rabano A, Avila J, Dierssen M, et al. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Translational Psychiatry. 6: e718. PMID 26784972 DOI: 10.1038/Tp.2015.214  0.277
2018 Espinosa-Carrasco J, Burokas A, Fructuoso M, Erb I, Martín-García E, Gutiérrez-Martos M, Notredame C, Maldonado R, Dierssen M. Time-course and dynamics of obesity-related behavioral changes induced by energy-dense foods in mice. Addiction Biology. 23: 531-543. PMID 29318700 DOI: 10.1111/Adb.12595  0.274
2018 Espino Gaurch M, Font-Llitjós M, Murillo-Cuesta S, Errasti-Murugarren E, Celaya AM, Girotto G, Vuckovic D, Mezzavilla M, Vilches C, Bodoy S, Sahún I, González L, Prat E, Zorzano A, Dierssen M, et al. Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss. Elife. 7. PMID 29355479 DOI: 10.7554/Elife.31511  0.273
2009 Dierssen M, Herault Y, Estivill X. Aneuploidy: from a physiological mechanism of variance to Down syndrome. Physiological Reviews. 89: 887-920. PMID 19584316 DOI: 10.1152/Physrev.00032.2007  0.273
2001 Weitzdoerfer R, Stolzlechner D, Dierssen M, Ferreres J, Fountoulakis M, Lubec G. Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain. Journal of Neural Transmission-Supplement. 347-59. PMID 11771757 DOI: 10.1007/978-3-7091-6262-0_29  0.272
2015 Bofill-De Ros X, Santos M, Vila-Casadesús M, Villanueva E, Andreu N, Dierssen M, Fillat C. Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges. Bmc Genomics. 16: 907. PMID 26546125 DOI: 10.1186/S12864-015-2160-6  0.269
2019 Xicota L, Rodríguez J, Langohr K, Fitó M, Dierssen M, de la Torre R. Effect of epigallocatechin gallate on the body composition and lipid profile of down syndrome individuals: Implications for clinical management. Clinical Nutrition (Edinburgh, Scotland). PMID 31229326 DOI: 10.1016/J.Clnu.2019.05.028  0.268
2022 Martinez de Lagran M, Elizalde-Torrent A, Paredes R, Clotet B, Dierssen M. Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndrome. Journal of Cellular and Molecular Medicine. PMID 35762509 DOI: 10.1111/jcmm.17411  0.266
2017 Xicota L, Rodriguez-Morato J, Dierssen M, de la Torre R. Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease. Current Drug Targets. 18: 174-195. PMID 26302801 DOI: 10.2174/1389450116666150825113655  0.262
1993 Vivas NM, Badia A, Màrmol F, Dierssen M. Differential effects of physostigmine and 1,2,3,4-tetrahydro-9-aminoacridine on the ß-adrenoceptor transduction system European Journal of Pharmacology. 245: 9-13. PMID 8386672 DOI: 10.1016/0922-4106(93)90163-4  0.261
2008 Vidal B, Serrano AL, Tjwa M, Suelves M, Ardite E, De Mori R, Baeza-Raja B, De Lagrán MM, Lafuste P, Ruiz-Bonilla V, Jardí M, Gherardi R, Christov C, Dierssen M, Carmeliet P, et al. Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway Genes and Development. 22: 1747-1752. PMID 18593877 DOI: 10.1101/Gad.465908  0.26
2009 Heyne A, Kiesselbach C, Sahún I, McDonald J, Gaiffi M, Dierssen M, Wolffgramm J. An animal model of compulsive food-taking behaviour. Addiction Biology. 14: 373-83. PMID 19740365 DOI: 10.1111/J.1369-1600.2009.00175.X  0.256
2019 Reeves RH, Delabar J, Potier MC, Bhattacharyya A, Head E, Lemere C, Dekker AD, De Deyn P, Caviedes P, Dierssen M, Busciglio J. Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society. Molecular Syndromology. 9: 279-286. PMID 30800043 DOI: 10.1159/000494231  0.254
2018 Fructuoso M, Rachdi L, Philippe E, Denis RG, Magnan C, Le Stunff H, Janel N, Dierssen M. Corrigendum to "Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome" [Free Radic. Biol. Med. 114 (2018) 122-130]. Free Radical Biology & Medicine. PMID 29525132 DOI: 10.1016/J.Freeradbiomed.2018.02.029  0.252
2003 Dierssen M. Special interest section--Down's syndrome: postgenomic approaches to neurobiological problems. Genes, Brain, and Behavior. 2: 152-5. PMID 12931788 DOI: 10.1034/J.1601-183X.2003.00027.X  0.246
2016 Catuara-Solarz S, Espinosa-Carrasco J, Erb I, Langohr K, Gonzalez JR, Notredame C, Dierssen M. Combined Treatment With Environmental Enrichment and (-)-Epigallocatechin-3-Gallate Ameliorates Learning Deficits and Hippocampal Alterations in a Mouse Model of Down Syndrome. Eneuro. 3. PMID 27844057 DOI: 10.1523/ENEURO.0103-16.2016  0.243
2014 Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, et al. The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies. British Journal of Pharmacology. 171: 3845-57. PMID 24750073 DOI: 10.1111/Bph.12741  0.241
1990 Dierssen M, Flórez J, Hurlé MA. Calcium channel modulation by dihydropyridines modifies sufentanil-induced antinociception in acute and tolerant conditions. Naunyn-Schmiedeberg's Archives of Pharmacology. 342: 559-65. PMID 1708855 DOI: 10.1007/Bf00169046  0.238
2023 Manubens-Gil L, Pons-Espinal M, Gener T, Ballesteros-Yañez I, de Lagrán MM, Dierssen M. Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A. Cerebral Cortex (New York, N.Y. : 1991). PMID 37997361 DOI: 10.1093/cercor/bhad431  0.238
1991 Dierssen M, Ruiz F, Flórez J, Hurlé MA. Ca2+ channel modulation by dihydropyridines modifies sufentanil-induced respiratory depression in cats. European Journal of Pharmacology. 198: 149-55. PMID 1713849 DOI: 10.1016/0014-2999(91)90614-V  0.232
2020 De Toma I, Ortega M, Catuara-Solarz S, Sierra C, Sabidó E, Dierssen M. Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment. Scientific Reports. 10: 16023. PMID 32994493 DOI: 10.1038/s41598-020-72625-z  0.232
2002 Garcia-Calatayud S, Ruiz JI, García-Fuentes M, Dierssen M, Flórez J, Crespo PS. Long-chain polyunsaturated fatty acids in rat maternal milk, offspring brain and peripheral tissues in essential fatty acid deficiency. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 40: 278-84. PMID 12005218 DOI: 10.1515/Cclm.2002.044  0.23
2014 Fillat C, Bofill-De Ros X, Santos M, Martín ED, Andreu N, Villanueva E, D'Amico D, Dierssen M, Altafaj X. Identification of key genes involved in Down syndrome pathogenesis by gene therapy | Identificación de genes clave implicados en el síndrome de Down mediante terapia génica Sd Revista Medica Internacional Sobre El Sindrome De Down. 18: 21-28. DOI: 10.1016/S1138-2074(14)70049-1  0.23
1994 Aguado F, Badía A, Baños J, Bosch F, Bozzo C, Camps P, Contreras J, Dierssen M, Escolano C, Görbig D, Muñoz-Torrero D, Pujol, Simón M, Vázquez M, Vivas N. Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease European Journal of Medicinal Chemistry. 29: 205-221. DOI: 10.1016/0223-5234(94)90039-6  0.229
2015 Rodríguez-Morató J, Xicota L, Fitó M, Farré M, Dierssen M, de la Torre R. Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases. Molecules (Basel, Switzerland). 20: 4655-80. PMID 25781069 DOI: 10.3390/Molecules20034655  0.228
2023 Pons-Espinal M, Manubens-Gil L, Gener T, Ballesteros-Yañez I, Martínez de Lagrán M, Dierssen M. Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of . Biorxiv : the Preprint Server For Biology. PMID 36945607 DOI: 10.1101/2023.03.09.531874  0.223
2022 Llambrich S, González R, Albaigès J, Wouters J, Marain F, Himmelreich U, Sharpe J, Dierssen M, Gsell W, Martínez-Abadías N, Vande Velde G. Multimodal Imaging of the Integrated Postnatal Development of Brain and Skull and Its Co-modulation With Neurodevelopment in a Down Syndrome Mouse Model. Frontiers in Medicine. 9: 815739. PMID 35223915 DOI: 10.3389/fmed.2022.815739  0.223
2023 Fructuoso M, Fernández-Blanco Á, Gallego-Román A, Sierra C, de Lagrán MM, Lorenzon N, De Toma I, Langohr K, Martín-García E, Maldonado R, Dairou J, Janel N, Dierssen M. Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model. Cellular and Molecular Life Sciences : Cmls. 80: 370. PMID 37989807 DOI: 10.1007/s00018-023-05009-x  0.223
1993 Ruiz F, Dierssen M, Flórez J, Hurlé MA. The Ca2+ channel agonist Bay K 8644 induces central respiratory depression in cats, an effect blocked by naloxone. European Journal of Pharmacology. 240: 155-61. PMID 7694855 DOI: 10.1016/0014-2999(93)90893-M  0.222
1992 Dierssen M, Marmol F, Vivas NM, Clos VM, Badia A. Effect Of 9-Amino-1, 2, 3, 4-Tetrahydroacridine On Passive Avoidance Retention And Ss-Adrenoceptor Linked Cyclic Amp Accumulation In Middle Aged Rats Behavioural Pharmacology. 3: 83. DOI: 10.1097/00008877-199204001-00255  0.222
2019 Espinosa-Carrasco J, Pulido TH, Erb I, Dierssen M, Ponomarenko J, Notredame C. Pergola-web: a web server for the visualization and analysis of longitudinal behavioral data using repurposed genomics tools and standards. Nucleic Acids Research. PMID 31106365 DOI: 10.1093/Nar/Gkz414  0.221
2020 Fernández-Blanco Á, Dierssen M. Rethinking Intellectual Disability from Neuro- to Astro-Pathology. International Journal of Molecular Sciences. 21. PMID 33261169 DOI: 10.3390/ijms21239039  0.22
2018 Espinosa-Carrasco J, Erb I, Hermoso Pulido T, Ponomarenko J, Dierssen M, Notredame C. Pergola: Boosting Visualization and Analysis of Longitudinal Data by Unlocking Genomic Analysis Tools. Iscience. 9: 244-257. PMID 30419504 DOI: 10.1016/J.Isci.2018.10.023  0.22
1993 Gascón S, Dierssen M, Màrmol F, Vivas NM, Badia A. Effects of age on α1-adrenoceptor subtypes in the heart ventricular muscle of the rat Journal of Pharmacy and Pharmacology. 45: 907-909. PMID 7904632 DOI: 10.1111/J.2042-7158.1993.Tb05618.X  0.22
1993 Ruiz F, Dierssen M, Flórez J, Hurlé MA. Potentiation of acute opioid-induced respiratory depression and reversal of tolerance by the calcium antagonist nimodipine in awake rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 348: 633-7. PMID 8133906 DOI: 10.1007/Bf00167240  0.22
2018 De Toma I, Grabowicz IE, Fructuoso M, Trujillano D, Wilczyński B, Dierssen M. Overweight Mice Show Coordinated Homeostatic and Hedonic Transcriptional Response across Brain. Eneuro. 5. PMID 30637329 DOI: 10.1523/ENEURO.0287-18.2018  0.216
2020 Dierssen M. Top ten discoveries of the year: Neurodevelopmental disorders. Free Neuropathology. 1. PMID 37283674 DOI: 10.17879/freeneuropathology-2020-2672  0.215
2011 Ziółkowska B, Gieryk A, Martín-García E, Burokas A, Maldonado R, McDonald J, Dierssen M, Przewłocki R. Expression regulation of opioid propeptides and dopamine receptors in the mesostriatal system by chronic intake of palatable foods Pharmacological Reports. 63: 259. DOI: 10.1016/S1734-1140(11)70487-X  0.213
1999 Martínez-Cué C, Baamonde C, Lumbreras MA, Vallina IF, Dierssen M, Flórez J. A murine model for Down syndrome shows reduced responsiveness to pain. Neuroreport. 10: 1119-22. PMID 10321494  0.212
2022 Sabariego-Navarro M, Fernández-Blanco Á, Sierra C, Dierssen M. Neurodevelopmental disorders: 2022 update. Free Neuropathology. 3. PMID 37284163 DOI: 10.17879/freeneuropathology-2022-3801  0.209
2021 Sierra C, De Toma I, Cascio LL, Vegas E, Dierssen M. Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome. Frontiers in Behavioral Neuroscience. 15: 772734. PMID 34803627 DOI: 10.3389/fnbeh.2021.772734  0.204
2023 Lorenzon N, Musoles-Lleó J, Turrisi F, Gomis-González M, De La Torre R, Dierssen M. State-of-the-art therapy for Down syndrome. Developmental Medicine and Child Neurology. PMID 36692980 DOI: 10.1111/dmcn.15517  0.204
1992 Dierssen M, Vivas N, Màrmol F, Badia A. COMPARATIVE EFFECTS OF 1,2,3,4-TETRAHYDRO-9-AMINOACRIDINE (THA) AND PHYSOSTIGMINE ON β-ADRENOCEPTOR TRANSDUCTION SYSTEM Clinical Neuropharmacology. 15. DOI: 10.1097/00002826-199202001-00258  0.2
2018 Olesti E, De Toma I, Ramaekers JG, Brunt TM, Carbó ML, Fernández-Avilés C, Robledo P, Farré M, Dierssen M, Pozo ÓJ, de la Torre R. Metabolomics predicts the pharmacological profile of new psychoactive substances. Journal of Psychopharmacology (Oxford, England). 269881118812103. PMID 30451567 DOI: 10.1177/0269881118812103  0.197
2023 Fernández-Blanco Á, Zamora-Moratalla A, Sabariego-Navarro M, Dierssen M. Defective engram allocation contributes to impaired fear memory performance in Down syndrome. Biorxiv : the Preprint Server For Biology. PMID 36711850 DOI: 10.1101/2023.01.11.523460  0.192
2023 Carriba P, Lorenzón N, Dierssen M. Neurodevelopmental disorders: 2023 update. Free Neuropathology. 4. PMID 37347033 DOI: 10.17879/freeneuropathology-2023-4701  0.189
2022 Arias A, Manubens-Gil L, Dierssen M. Fluorescent transgenic mouse models for whole-brain imaging in health and disease. Frontiers in Molecular Neuroscience. 15: 958222. PMID 36211979 DOI: 10.3389/fnmol.2022.958222  0.189
2021 Starbuck JM, Llambrich S, Gonzàlez R, Albaigès J, Sarlé A, Wouters J, González A, Sevillano X, Sharpe J, De La Torre R, Dierssen M, Vande Velde G, Martínez-Abadías N. Green tea extracts containing epigallocatechin-3-gallate modulate facial development in Down syndrome. Scientific Reports. 11: 4715. PMID 33633179 DOI: 10.1038/s41598-021-83757-1  0.179
2019 Lagran MMD, Ruiz-Mejias M, Sanchez-Vives M, Dierssen M. Involvement of Dyrk1A, a down syndrome candidate gene, in the thalamocortical connectivity European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.669  0.179
2021 Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, et al. Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition. Frontiers in Molecular Neuroscience. 14: 664912. PMID 34025350 DOI: 10.3389/fnmol.2021.664912  0.178
2021 De Toma I, Sierra C, Dierssen M. Meta-analysis of transcriptomic data reveals clusters of consistently deregulated gene and disease ontologies in Down syndrome. Plos Computational Biology. 17: e1009317. PMID 34570756 DOI: 10.1371/journal.pcbi.1009317  0.176
2021 Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, et al. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Molecular Syndromology. 12: 202-218. PMID 34421499 DOI: 10.1159/000514437  0.172
2021 Echeverry LM, Starbuck J, Gonzàlez R, Sarlé A, Sharpe J, Torre R, Dierssen M, Martínez‐Abadías N. Altered Genetic Expression Disrupts Facial Ontogenetic Trajectory in Down Syndrome and DYRK1A Haploinsufficiency The Faseb Journal. 35. DOI: 10.1096/FASEBJ.2021.35.S1.03721  0.169
2021 Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EM, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, et al. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society Molecular Syndromology. 12: 202-218. DOI: 10.1159/000514437  0.168
2023 Lindberg MF, Deau E, Miege F, Greverie M, Roche D, George N, George P, Merlet L, Gavard J, Brugman SJT, Aret E, Tinnemans P, de Gelder R, Sadownik J, Verhofstad E, ... ... Dierssen M, et al. Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer's Disease Drug Candidate. Journal of Medicinal Chemistry. PMID 38051674 DOI: 10.1021/acs.jmedchem.3c01888  0.166
2020 De Lagran MM, Martin E, Valjent E, Dierssen M. P.688 Dyrk1A, a Down syndrome candidate gene, regulates obesity development acting over dopaminergic D2 receptor expressing neurons European Neuropsychopharmacology. 40: S392-S393. DOI: 10.1016/j.euroneuro.2020.09.509  0.159
2022 Spruce T, Plass M, Gohr A, Ray D, Martínez de Lagrán M, Rot G, Nóvoa A, Burguera D, Permanyer J, Miret M, Zheng H, Swanson MS, Morris Q, Mallo M, Dierssen M, et al. The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians. Plos Biology. 20: e3001615. PMID 35476669 DOI: 10.1371/journal.pbio.3001615  0.156
2021 Zamora-Moratalla A, Martínez de Lagrán M, Dierssen M. Neurodevelopmental disorders: 2021 update. Free Neuropathology. 2. PMID 37284629 DOI: 10.17879/freeneuropathology-2021-3268  0.154
2021 Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, Brandão AC, Carfi A, Carmona-Iragui M, Chicoine BA, Ghosh S, Lakhanpaul M, Manso C, Mayer MA, Ortega MDC, et al. Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey. Eclinicalmedicine. 100769. PMID 33644721 DOI: 10.1016/j.eclinm.2021.100769  0.146
2020 Del Carmen Ortega M, Borrel JM, de Jesús Bermejo T, González-Lamuño D, Manso C, de la Torre R, Mayer MA, de Asúa DR, Dierssen M. Lessons from individuals with Down syndrome during COVID-19. The Lancet. Neurology. 19: 974-975. PMID 33212059 DOI: 10.1016/S1474-4422(20)30401-4  0.143
2020 Llambrich S, Wouters J, Himmelreich U, Dierssen M, Sharpe J, Gsell W, Martínez-Abadías N, Vande Velde G. ViceCT and whiceCT for simultaneous high-resolution visualization of craniofacial, brain and ventricular anatomy from micro-computed tomography. Scientific Reports. 10: 18772. PMID 33128010 DOI: 10.1038/s41598-020-75720-3  0.143
2019 Fructuoso M, Espinosa-Carrasco J, Erb I, Notredame C, Dierssen M. Protocol for Measuring Compulsive-like Feeding Behavior in Mice. Bio-Protocol. 9: e3308. PMID 33654818 DOI: 10.21769/BioProtoc.3308  0.141
2022 Cieuta-Walti C, Cuenca-Royo A, Langohr K, Rakic C, López-Vílchez MÁ, Lirio J, González-Lamuño Leguina D, González TB, García JG, Roure MR, Aldea-Perona A, Forcano L, Gomis-Gonzalez M, Cés SV, Lacaille F, ... ... Dierssen M, et al. Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study). Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 35951014 DOI: 10.1016/j.gim.2022.06.011  0.141
2021 Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, et al. Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Medicine. PMID 34797469 DOI: 10.1007/s12017-021-08695-7  0.14
2021 Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, et al. Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Medicine. PMID 33948879 DOI: 10.1007/s12017-021-08657-z  0.14
1999 Baamonde C, Lumbreras MA, Martínez-Cué C, Vallina IF, García-Calatayud S, Flórez J, Dierssen M. Short-term effects of postnatal manipulation on central beta-adrenoceptor transmission. Stress (Amsterdam, Netherlands). 3: 147-62. PMID 10938576 DOI: 10.3109/10253899909001119  0.136
2020 Hüls A, Costa ACS, Dierssen M, Baksh RA, Bargagna S, Baumer NT, Brandão AC, Carfi A, Carmona-Iragui M, Chicoine BA, Ghosh S, Lakhanpaul M, Manso C, Mayer MA, Del Carmen Ortega M, et al. An international survey on the impact of COVID-19 in individuals with Down syndrome. Medrxiv : the Preprint Server For Health Sciences. PMID 33173907 DOI: 10.1101/2020.11.03.20225359  0.135
2022 Pisanu C, Severino G, De Toma I, Dierssen M, Fusar-Poli P, Gennarelli M, Lio P, Maffioletti E, Maron E, Mehta D, Minelli A, Potier MC, Serretti A, Stacey D, van Westrhenen R, et al. Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 55: 112-157. PMID 35016057 DOI: 10.1016/j.euroneuro.2021.12.005  0.133
2021 De Toma I, Dierssen M. Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19. Scientific Reports. 11: 1930. PMID 33479353 DOI: 10.1038/s41598-021-81451-w  0.133
2002 Baamonde C, Lumbreras MA, MartInez-Cué C, Vallina IF, Flórez J, Dierssen M. Postnatal handling induces long-term modifications in central beta-noradrenergic signalling in rats. Stress (Amsterdam, Netherlands). 5: 137-47. PMID 12186692 DOI: 10.1080/10253890290027903  0.126
2020 Murillo-Cuesta S, Artuch R, Asensio F, de la Villa P, Dierssen M, Enríquez JA, Fillat C, Fourcade S, Ibáñez B, Montoliu L, Oliver E, Pujol A, Salido E, Vallejo M, Varela-Nieto I. The Value of Mouse Models of Rare Diseases: A Spanish Experience. Frontiers in Genetics. 11: 583932. PMID 33173540 DOI: 10.3389/fgene.2020.583932  0.125
2009 Dierssen M. Music: A Basic Drive or a Key Element in the Human Brain? International Medical Review On Down Syndrome. 13: 17. DOI: 10.1016/S2171-9748(09)70017-0  0.124
2021 Illouz T, Biragyn A, Iulita MF, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, London J, Mobley W, et al. Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. Frontiers in Immunology. 12: 621440. PMID 34248930 DOI: 10.3389/fimmu.2021.621440  0.118
2021 Real de Asua D, Mayer MA, Ortega MDC, Borrel JM, Bermejo TJ, González-Lamuño D, Manso C, Moldenhauer F, Carmona-Iragui M, Hüls A, Sherman SL, Strydom A, de la Torre R, Dierssen M. Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome. Journal of Clinical Medicine. 10. PMID 34442043 DOI: 10.3390/jcm10163748  0.117
2022 Bonilla-Pons SÀ, Nakagawa S, Bahima EG, Fernández-Blanco Á, Pesaresi M, D'Antin JC, Sebastian-Perez R, Greco D, Domínguez-Sala E, Gómez-Riera R, Compte RIB, Dierssen M, Pulido NM, Cosma MP. Müller glia fused with adult stem cells undergo neural differentiation in human retinal models. Ebiomedicine. 77: 103914. PMID 35278743 DOI: 10.1016/j.ebiom.2022.103914  0.117
2021 Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L, Sherman SL, Strydom A, Bargagna S, Brandão AC, Costa ACS, Feany PT, Chicoine BA, Ghosh S, Rebillat AS, et al. COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey. Journal of Clinical Medicine. 10. PMID 34768645 DOI: 10.3390/jcm10215125  0.112
2022 Pinku H, Hüls A, Feany PT, Baumer N, Dierssen M, Bargagna S, Costa AC, Chicoine BA, Rebillat AS, Sgandurra G, Valentini D, Rohrer RT, Levin J, Lakhanpaul M, Carfì A, et al. Differences in clinical presentation, severity, and treatment of COVID-19 among individuals with Down syndrome from India and high-income countries: Data from the Trisomy 21 Research Society survey. Journal of Global Health. 12: 05035. PMID 35932238 DOI: 10.7189/jogh.12.05035  0.111
2023 Sathyanarayanan A, Mueller TT, Ali Moni M, Schueler K, Baune BT, Lio P, Mehta D, Baune BT, Dierssen M, Ebert B, Fabbri C, Fusar-Poli P, Gennarelli M, Harmer C, Howes OD, et al. Multi-omics data integration methods and their applications in psychiatric disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 69: 26-46. PMID 36706689 DOI: 10.1016/j.euroneuro.2023.01.001  0.107
1988 Hurlé MA, Dierssen MM, Morin-Surun MP, Oceja C, Flórez J. Respiratory actions induced by cholecystokinin at the brainstem level. Peptides. 9: 809-15. PMID 3226957 DOI: 10.1016/0196-9781(88)90126-X  0.103
1992 Dierssen M, Màrmol F, Vivas NM, Clos MV, Badia A. Post-train administration of 9-amino-1,2,3,4-tetrahydroacridine enhances passive avoidance retention and decreases beta-adrenoceptor-linked cyclic AMP formation in middle-aged rats. Brain Research. 586: 117-20. PMID 1380875 DOI: 10.1016/0006-8993(92)91379-S  0.102
1986 Hurlé MA, Dierssen MM, Flórez J. Mechanism of the respiratory action of pentobarbital at the medullary and pontine levels. European Journal of Pharmacology. 125: 225-32. PMID 3017725 DOI: 10.1016/0014-2999(86)90031-2  0.101
2021 Dierssen M, Barone E. Editorial: Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap! Frontiers in Neuroscience. 15: 730378. PMID 34447295 DOI: 10.3389/fnins.2021.730378  0.096
2021 Dierssen M, Barone E. Editorial: Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap! Frontiers in Neuroscience. 15. DOI: 10.3389/fnins.2021.730378  0.096
2021 Xicota L, De Toma I, Maffioletti E, Pisanu C, Squassina A, Baune BT, Potier MC, Stacey D, Dierssen M. Recommendations for pharmacotranscriptomic profiling of drug response in CNS disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 54: 41-53. PMID 34743061 DOI: 10.1016/j.euroneuro.2021.10.005  0.091
2013 Del Pino I, García-Frigola C, Alvarez E, Martínez de Lagran M, Ciceri G, Dierssen M, Canals S, Marín O, Rico B. S.28.01 GABAergic interneuron synaptic dysfunction and schizophrenia European Neuropsychopharmacology. 23: S152. DOI: 10.1016/S0924-977X(13)70226-8  0.065
2022 Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A, Chicoine BA, Ghosh S, Lakhanpaul M, Levin J, Lunsky Y, et al. COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated. Vaccines. 10. PMID 35455279 DOI: 10.3390/vaccines10040530  0.053
2012 Dierssen M, de la Torre R. Preface. Progress in Brain Research. 197: vii. PMID 22541297 DOI: 10.1016/B978-0-444-54299-1.00019-4  0.011
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