David W. Howells - Publications

Affiliations: 
Medicine University of Melbourne, Australia 

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Nguyen VA, Crewther SG, Howells DW, Wijeratne T, Ma H, Hankey GJ, Davis S, Donnan GA, Carey LM. Acute Routine Leukocyte and Neutrophil Counts Are Predictive of Poststroke Recovery at 3 and 12 Months Poststroke: An Exploratory Study. Neurorehabilitation and Neural Repair. 34: 844-855. PMID 32940147 DOI: 10.1177/1545968320948607  0.355
2020 Nguyen VA, Riddell N, Crewther SG, Faou P, Rajapaksha H, Howells DW, Hankey GJ, Wijeratne T, Ma H, Davis S, Donnan GA, Carey LM. Longitudinal Stroke Recovery Associated With Dysregulation of Complement System-A Proteomics Pathway Analysis. Frontiers in Neurology. 11: 692. PMID 32849183 DOI: 10.3389/Fneur.2020.00692  0.359
2020 Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. The Journal of Physiology. PMID 32666574 DOI: 10.1113/Jp280389  0.301
2020 Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X20943823. PMID 32663096 DOI: 10.1177/0271678X20943823  0.301
2020 Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. Bmc Veterinary Research. 16: 242. PMID 32660541 DOI: 10.1186/S12917-020-02451-Y  0.301
2020 Premilovac D, Blackwood SJ, Ramsay CJ, Keske MA, Howells DW, Sutherland BA. Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X20905493. PMID 32063081 DOI: 10.1177/0271678X20905493  0.385
2019 Landowski LM, Niego B, Sutherland BA, Hagemeyer CE, Howells DW. Applications of Nanotechnology in the Diagnosis and Therapy of Stroke. Seminars in Thrombosis and Hemostasis. PMID 31858516 DOI: 10.1055/S-0039-3399568  0.397
2019 Liu Y, Michalska AE, Dottori M, Eaton E, Courtney JM, Antonic A, Howells DW. Differential susceptibility of human neural progenitors and neurons to ischaemic injury. Brain Research Bulletin. PMID 31837459 DOI: 10.1016/J.Brainresbull.2019.12.005  0.331
2019 Goodin P, Lamp G, Vidyasagar R, Connelly A, Rose S, Campbell BCV, Tse T, Ma H, Howells D, Hankey GJ, Davis S, Donnan G, Carey LM. Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores. Neural Plasticity. 2019: 2357107. PMID 31467520 DOI: 10.1155/2019/2357107  0.306
2018 Beard DJ, Hadley G, Thurley N, Howells DW, Sutherland BA, Buchan AM. The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies. International Journal of Stroke : Official Journal of the International Stroke Society. 1747493018816503. PMID 30489210 DOI: 10.1177/1747493018816503  0.365
2018 Dagonnier M, Wilson WJ, Favaloro JM, Rewell SSJ, Lockett LJ, Sastra SA, Jeffreys AL, Dewey HM, Donnan GA, Howells DW. Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature. Plos One. 13: e0206321. PMID 30439964 DOI: 10.1371/Journal.Pone.0206321  0.388
2018 Antonic A, Dottori M, Macleod MR, Donnan GA, Howells DW. NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. PMID 29673616 DOI: 10.1016/J.Jstrokecerebrovasdis.2018.03.015  0.404
2018 Liu Y, Eaton ED, Wills TE, McCann SK, Antonic A, Howells DW. Human Ischaemic Cascade Studies Using SH-SY5Y Cells: a Systematic Review and Meta-Analysis. Translational Stroke Research. PMID 29572690 DOI: 10.1007/S12975-018-0620-4  0.335
2017 Dagonnier M, Cooke IR, Faou P, Sidon TK, Dewey HM, Donnan GA, Howells DW. Discovery and Longitudinal Evaluation of Candidate Biomarkers for Ischaemic Stroke by Mass Spectrometry-Based Proteomics. Biomarker Insights. 12: 1177271917749216. PMID 29308009 DOI: 10.1177/1177271917749216  0.385
2017 Bahor Z, Liao J, Macleod MR, Bannach-Brown A, McCann SK, Wever KE, Thomas J, Ottavi T, Howells DW, Rice A, Ananiadou S, Sena E. Risk of bias reporting in the recent animal focal cerebral ischaemia literature. Clinical Science (London, England : 1979). 131: 2525-2532. PMID 29026002 DOI: 10.1042/Cs20160722  0.365
2017 Borschmann KN, Rewell SS, Iuliano S, Ghasem-Zadeh A, Davey RA, Ho H, Skeers PN, Bernhardt J, Howells DW. Reduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot study. Plos One. 12: e0172889. PMID 28278253 DOI: 10.1371/Journal.Pone.0172889  0.322
2017 Rewell SS, Churilov L, Sidon TK, Aleksoska E, Cox SF, Macleod MR, Howells DW. Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials. Plos One. 12: e0171688. PMID 28182727 DOI: 10.1371/Journal.Pone.0171688  0.42
2017 Rewell SS, Jeffreys AL, Sastra SA, Cox SF, Fernandez JA, Aleksoska E, van der Worp HB, Churilov L, Macleod MR, Howells DW. Hypothermia revisited: Impact of ischaemic duration and between experiment variability. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X16688704. PMID 28084873 DOI: 10.1177/0271678X16688704  0.388
2016 Nguyen VA, Carey LM, Giummarra L, Faou P, Cooke I, Howells DW, Tse T, Macaulay SL, Ma H, Davis SM, Donnan GA, Crewther SG. A Pathway Proteomic Profile of Ischemic Stroke Survivors Reveals Innate Immune Dysfunction in Association with Mild Symptoms of Depression - A Pilot Study. Frontiers in Neurology. 7: 85. PMID 27379006 DOI: 10.3389/Fneur.2016.00085  0.374
2016 Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM. Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis. Plos Biology. 14: e1002468. PMID 27244556 DOI: 10.1371/Journal.Pbio.1002468  0.32
2016 Yang X, Zhang X, Li Y, Han S, Howells DW, Li S, Li J. cPKCβ-mediated phosphorylation inhibits CRMP2 proteolysis and alleviates ischemic injury in cultured cortical neurons and ischemic stroke-induced mice. Journal of Neurochemistry. PMID 26788931 DOI: 10.1111/Jnc.13538  0.369
2015 Kleikers PW, Hooijmans C, Göb E, Langhauser F, Rewell SS, Radermacher K, Ritskes-Hoitinga M, Howells DW, Kleinschnitz C, Schmidt HH. A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Scientific Reports. 5: 13428. PMID 26310318 DOI: 10.1038/Srep13428  0.375
2015 Pascoe MC, Howells DW, Crewther DP, Carey LM, Crewther SG. Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat. Neuropsychiatric Disease and Treatment. 11: 153-64. PMID 25609971 DOI: 10.2147/Ndt.S72925  0.303
2015 Carey LM, Crewther S, Salvado O, Lindén T, Connelly A, Wilson W, Howells DW, Churilov L, Ma H, Tse T, Rose S, Palmer S, Bougeat P, Campbell BC, Christensen S, et al. STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol. International Journal of Stroke : Official Journal of the International Stroke Society. 10: 636-44. PMID 24206623 DOI: 10.1111/Ijs.12190  0.382
2014 McCann SK, Irvine C, Mead GE, Sena ES, Currie GL, Egan KE, Macleod MR, Howells DW. Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis. Stroke; a Journal of Cerebral Circulation. 45: 3055-63. PMID 25184357 DOI: 10.1161/Strokeaha.114.006304  0.43
2014 Dagonnier M, Howells DW, Donnan GA, Dewey HM. Recruitment to trials of late thrombolysis: lessons from the EXTEND study. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 21: 1215-9. PMID 24583057 DOI: 10.1016/J.Jocn.2013.10.033  0.4
2014 Pascoe MC, Howells DW, Crewther DP, Constantinou N, Carey LM, Rewell SS, Turchini GM, Kaur G, Crewther SG. Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment. Frontiers in Neurology. 5: 14. PMID 24567728 DOI: 10.3389/Fneur.2014.00014  0.344
2014 Egan KJ, Janssen H, Sena ES, Longley L, Speare S, Howells DW, Spratt NJ, Macleod MR, Mead GE, Bernhardt J. Exercise reduces infarct volume and facilitates neurobehavioral recovery: results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia. Neurorehabilitation and Neural Repair. 28: 800-12. PMID 24553105 DOI: 10.1177/1545968314521694  0.325
2014 Antonic A, Dottori M, Leung J, Sidon K, Batchelor PE, Wilson W, Macleod MR, Howells DW. Hypothermia protects human neurons. International Journal of Stroke : Official Journal of the International Stroke Society. 9: 544-52. PMID 24393199 DOI: 10.1111/Ijs.12224  0.346
2014 Howells DW, Sena ES, Macleod MR. Bringing rigour to translational medicine. Nature Reviews. Neurology. 10: 37-43. PMID 24247324 DOI: 10.1038/Nrneurol.2013.232  0.355
2014 Ma H, Campbell B, Parsons M, Christensen S, Churilov L, Howells D, Carey L, Hsu C, Davis S, Donnan G. 79. : EXtending the time for Thombolysis in Emergency Neurological Deficits: The EXTEND Trial Journal of Clinical Neuroscience. 21: 2057-2058. DOI: 10.1016/J.Jocn.2014.06.093  0.395
2013 Batchelor PE, Wills TE, Skeers P, Battistuzzo CR, Macleod MR, Howells DW, Sena ES. Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure. Plos One. 8: e72659. PMID 24009695 DOI: 10.1371/Journal.Pone.0072659  0.318
2013 Batchelor PE, Skeers P, Antonic A, Wills TE, Howells DW, Macleod MR, Sena ES. Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury. Plos One. 8: e71317. PMID 23951131 DOI: 10.1371/Journal.Pone.0071317  0.342
2013 Tsilidis KK, Panagiotou OA, Sena ES, Aretouli E, Evangelou E, Howells DW, Al-Shahi Salman R, Macleod MR, Ioannidis JP. Evaluation of excess significance bias in animal studies of neurological diseases. Plos Biology. 11: e1001609. PMID 23874156 DOI: 10.1371/Journal.Pbio.1001609  0.333
2013 O'Collins VE, Donnan GA, Macleod MR, Howells DW. Hypertension and experimental stroke therapies. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1141-7. PMID 23736641 DOI: 10.1038/Jcbfm.2013.88  0.38
2013 Dirnagl U, Hakim A, Macleod M, Fisher M, Howells D, Alan SM, Steinberg G, Planas A, Boltze J, Savitz S, Iadecola C, Meairs S. A concerted appeal for international cooperation in preclinical stroke research. Stroke; a Journal of Cerebral Circulation. 44: 1754-60. PMID 23598526 DOI: 10.1161/Strokeaha.113.000734  0.409
2013 Howells DW, Macleod MR. Evidence-based translational medicine. Stroke; a Journal of Cerebral Circulation. 44: 1466-71. PMID 23559263 DOI: 10.1161/Strokeaha.113.000469  0.409
2013 Sena ES, Jeffreys AL, Cox SF, Sastra SA, Churilov L, Rewell S, Batchelor PE, van der Worp HB, Macleod MR, Howells DW. The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine. International Journal of Stroke : Official Journal of the International Stroke Society. 8: 180-5. PMID 22759525 DOI: 10.1111/J.1747-4949.2012.00834.X  0.416
2012 Antonic A, Sena ES, Donnan GA, Howells DW. Human in vitro models of ischaemic stroke: a test bed for translation. Translational Stroke Research. 3: 306-9. PMID 24323805 DOI: 10.1007/S12975-012-0201-X  0.357
2012 Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, ... ... Howells DW, et al. A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 490: 187-91. PMID 23060188 DOI: 10.1038/Nature11556  0.373
2012 Sharma V, Ling TW, Rewell SS, Hare DL, Howells DW, Kourakis A, Wookey PJ. A novel population of α-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 2055-65. PMID 22805872 DOI: 10.1038/Jcbfm.2012.107  0.314
2012 Ankolekar S, Rewell S, Howells DW, Bath PM. The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals. International Journal of Stroke : Official Journal of the International Stroke Society. 7: 386-97. PMID 22712740 DOI: 10.1111/J.1747-4949.2012.00802.X  0.422
2012 Howells DW, Sena ES, O'Collins V, Macleod MR. Improving the efficiency of the development of drugs for stroke. International Journal of Stroke : Official Journal of the International Stroke Society. 7: 371-7. PMID 22712738 DOI: 10.1111/J.1747-4949.2012.00805.X  0.344
2012 Lees JS, Sena ES, Egan KJ, Antonic A, Koblar SA, Howells DW, Macleod MR. Stem cell-based therapy for experimental stroke: a systematic review and meta-analysis. International Journal of Stroke : Official Journal of the International Stroke Society. 7: 582-8. PMID 22687044 DOI: 10.1111/J.1747-4949.2012.00797.X  0.369
2012 O'Collins VE, Macleod MR, Donnan GA, Howells DW. Evaluation of combination therapy in animal models of cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 585-97. PMID 22293990 DOI: 10.1038/Jcbfm.2011.203  0.371
2012 Ma H, Parsons MW, Christensen S, Campbell BC, Churilov L, Connelly A, Yan B, Bladin C, Phan T, Barber AP, Read S, Hankey GJ, Markus R, Wijeratne T, Grimley R, ... ... Howells DW, et al. A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). International Journal of Stroke : Official Journal of the International Stroke Society. 7: 74-80. PMID 22188854 DOI: 10.1111/J.1747-4949.2011.00730.X  0.405
2011 Donnan GA, Davis SM, Parsons MW, Ma H, Dewey HM, Howells DW. How to make better use of thrombolytic therapy in acute ischemic stroke. Nature Reviews. Neurology. 7: 400-9. PMID 21670766 DOI: 10.1038/Nrneurol.2011.89  0.391
2011 O'Collins VE, Donnan GA, Howells DW. History of animal models of stroke International Journal of Stroke. 6: 77-78. PMID 21205245 DOI: 10.1111/J.1747-4949.2010.00543.X  0.403
2011 O'Collins VE, Macleod MR, Cox SF, Van Raay L, Aleksoska E, Donnan GA, Howells DW. Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 962-75. PMID 20978519 DOI: 10.1038/Jcbfm.2010.184  0.412
2011 Spratt NJ, Donnan GA, McLeod DD, Howells DW. 'Salvaged' stroke ischaemic penumbra shows significant injury: studies with the hypoxia tracer FMISO. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 934-43. PMID 20877386 DOI: 10.1038/Jcbfm.2010.174  0.365
2011 Sharma V, Ling T, Wookey P, Rewell S, Howells D, Hare D. The Spatio-temporal Distribution of Migrating Pericytes in a Rat Model of Stroke: The Expression of Definitive Cell Markers Heart Lung and Circulation. 20. DOI: 10.1016/J.Hlc.2011.05.055  0.347
2010 Janssen H, Bernhardt J, Collier JM, Sena ES, McElduff P, Attia J, Pollack M, Howells DW, Nilsson M, Calford MB, Spratt NJ. An enriched environment improves sensorimotor function post-ischemic stroke. Neurorehabilitation and Neural Repair. 24: 802-13. PMID 20834046 DOI: 10.1177/1545968310372092  0.416
2010 Sena ES, Briscoe CL, Howells DW, Donnan GA, Sandercock PA, Macleod MR. Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1905-13. PMID 20648038 DOI: 10.1038/Jcbfm.2010.116  0.406
2010 Howells DW, Porritt MJ, Rewell SS, O'Collins V, Sena ES, van der Worp HB, Traystman RJ, Macleod MR. Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1412-31. PMID 20485296 DOI: 10.1038/Jcbfm.2010.66  0.42
2010 Porritt MJ, Chen M, Rewell SS, Dean RG, Burrell LM, Howells DW. ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1520-6. PMID 20407464 DOI: 10.1038/Jcbfm.2010.57  0.3
2010 Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR. Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. Plos Biology. 8: e1000344. PMID 20361022 DOI: 10.1371/Journal.Pbio.1000344  0.38
2010 Howells DW, Donnan GA. Where will the next generation of stroke treatments come from? Plos Medicine. 7: e1000224. PMID 20208999 DOI: 10.1371/Journal.Pmed.1000224  0.399
2010 Rewell SS, Fernandez JA, Cox SF, Spratt NJ, Hogan L, Aleksoska E, van Raay L, Liberatore GT, Batchelor PE, Howells DW. Inducing stroke in aged, hypertensive, diabetic rats. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 729-33. PMID 20068574 DOI: 10.1038/Jcbfm.2009.273  0.388
2010 Jerndal M, Forsberg K, Sena ES, Macleod MR, O'Collins VE, Linden T, Nilsson M, Howells DW. A systematic review and meta-analysis of erythropoietin in experimental stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 961-8. PMID 20040929 DOI: 10.1038/Jcbfm.2009.267  0.42
2009 Spratt NJ, Donnan GA, Howells DW. Characterisation of the timing of binding of the hypoxia tracer FMISO after stroke Brain Research. 1288: 135-142. PMID 19595680 DOI: 10.1016/J.Brainres.2009.06.102  0.37
2009 Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke; a Journal of Cerebral Circulation. 40: 2244-50. PMID 19246690 DOI: 10.1161/Strokeaha.108.541128  0.411
2009 Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. International Journal of Stroke : Official Journal of the International Stroke Society. 4: 3-5. PMID 19236488 DOI: 10.1111/J.1747-4949.2009.00241.X  0.412
2009 Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 221-3. PMID 18797473 DOI: 10.1038/Jcbfm.2008.101  0.411
2009 Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW. Good laboratory practice: preventing introduction of bias at the bench. Stroke; a Journal of Cerebral Circulation. 40: e50-2. PMID 18703798 DOI: 10.1161/Strokeaha.108.525386  0.415
2008 Macleod MR, van der Worp HB, Sena ES, Howells DW, Dirnagl U, Donnan GA. Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke; a Journal of Cerebral Circulation. 39: 2824-9. PMID 18635842 DOI: 10.1161/Strokeaha.108.515957  0.362
2008 Spratt NJ, Donnan GA, Howells DW. 204: Fluoromisonidazole (FMISO) in stroke – identifies ischaemic penumbra and early infarct core Journal of Clinical Neuroscience. 15: 338. DOI: 10.1016/J.Jocn.2007.07.008  0.381
2007 Sena E, Worp HBvd, Howells D, Macleod M. How can we improve the pre-clinical development of drugs for stroke? Trends in Neurosciences. 30: 433-439. PMID 17765332 DOI: 10.1016/J.Tins.2007.06.009  0.373
2007 van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain : a Journal of Neurology. 130: 3063-74. PMID 17478443 DOI: 10.1093/Brain/Awm083  0.428
2007 Donnan GA, Howells DW. Neuroprotection: where to now? Future Neurology. 2: 513-521. DOI: 10.2217/14796708.2.5.513  0.437
2006 Spratt NJ, Ackerman U, Tochon-Danguy HJ, Donnan GA, Howells DW. Characterization of fluoromisonidazole binding in stroke. Stroke. 37: 1862-7. PMID 16763190 DOI: 10.1161/01.Str.0000226908.93295.9D  0.374
2006 Spratt NJ, Fernandez J, Chen M, Rewell S, Cox S, van Raay L, Hogan L, Howells DW. Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats. Journal of Neuroscience Methods. 155: 285-90. PMID 16513179 DOI: 10.1016/J.Jneumeth.2006.01.020  0.367
2006 O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1,026 experimental treatments in acute stroke. Annals of Neurology. 59: 467-77. PMID 16453316 DOI: 10.1002/Ana.20741  0.336
2006 Nilupul Perera M, Ma HK, Arakawa S, Howells DW, Markus R, Rowe CC, Donnan GA. Inflammation following stroke. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 13: 1-8. PMID 16410192 DOI: 10.1016/J.Jocn.2005.07.005  0.413
2005 Reddrop C, Moldrich RX, Beart PM, Farso M, Liberatore GT, Howells DW, Petersen KU, Schleuning WD, Medcalf RL. Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury. Stroke; a Journal of Cerebral Circulation. 36: 1241-6. PMID 15879331 DOI: 10.1161/01.Str.0000166050.84056.48  0.304
2005 Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA. Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 25: 713-21. PMID 15703698 DOI: 10.1038/Sj.Jcbfm.9600064  0.423
2005 Macleod MR, O'Collins T, Horky LL, Howells DW, Donnan GA. Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke. Journal of Pineal Research. 38: 35-41. PMID 15617535 DOI: 10.1111/J.1600-079X.2004.00172.X  0.419
2005 Spratt NJ, Fernandez JAC, Chen M, Rewell SSJ, Cox SF, Raay Lv, Hogan L, Howells DW. An improved technique for silicone-coating the suture used in rat MCA occlusion increases stroke induction rate, reduces mortality, and is effective across a wide weight and age range Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0542  0.317
2005 O'Collins T, Macleod M, Horky L, Young D, Donnan G, Howells D. Quality of preclinical evidence for neuroprotection in stroke Journal of Cerebral Blood Flow & Metabolism. 25: S144-S144. DOI: 10.1038/Sj.Jcbfm.9591524.0144  0.387
2004 Falcao AL, Reutens DC, Markus R, Koga M, Read SJ, Tochon-Danguy H, Sachinidis J, Howells DW, Donnan GA. The resistance to ischemia of white and gray matter after stroke. Annals of Neurology. 56: 695-701. PMID 15505775 DOI: 10.1002/Ana.20265  0.347
2004 Macleod MR, O'Collins T, Howells DW, Donnan GA. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke; a Journal of Cerebral Circulation. 35: 1203-8. PMID 15060322 DOI: 10.1161/01.Str.0000125719.25853.20  0.375
2004 Saita K, Chen M, Spratt NJ, Porritt MJ, Liberatore GT, Read SJ, Levi CR, Donnan GA, Ackermann U, Tochon-Danguy HJ, Sachinidis JI, Howells DW. Imaging the ischemic penumbra with 18F-fluoromisonidazole in a rat model of ischemic stroke. Stroke; a Journal of Cerebral Circulation. 35: 975-80. PMID 15017016 DOI: 10.1161/01.Str.0000121647.01941.Ba  0.335
2003 Donnan GA, Howells DW, Markus R, Toni D, Davis SM. Can the time window for administration of thrombolytics in stroke be increased? Cns Drugs. 17: 995-1011. PMID 14594441 DOI: 10.2165/00023210-200317140-00001  0.408
2002 Phan TG, Wright PM, Markus R, Howells DW, Davis SM, Donnan GA. Salvaging the ischaemic penumbra: More than just reperfusion? Clinical and Experimental Pharmacology and Physiology. 29: 1-10. PMID 11917903 DOI: 10.1046/J.1440-1681.2002.03609.X  0.369
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