| Year |
Citation |
Score |
| 2020 |
Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053 |
0.367 |
|
| 2020 |
Royea J, Lacalle-Aurioles M, Trigiani LJ, Fermigier A, Hamel E. AT2R's (Angiotensin II Type 2 Receptor's) Role in Cognitive and Cerebrovascular Deficits in a Mouse Model of Alzheimer Disease. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11914. PMID 32362228 DOI: 10.1161/Hypertensionaha.119.14431 |
0.374 |
|
| 2020 |
Trigiani LJ, Lacalle-Aurioles M, Bourourou M, Li L, Greenhalgh AD, Zarruk JG, David S, Fehlings MG, Hamel E. Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia. Glia. PMID 32154952 DOI: 10.1002/Glia.23815 |
0.335 |
|
| 2019 |
Royea J, Martinot P, Hamel E. Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease. Neurobiology of Disease. 134: 104644. PMID 31669735 DOI: 10.1016/J.Nbd.2019.104644 |
0.399 |
|
| 2019 |
Trigiani LJ, Royea J, Tong XK, Hamel E. Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901002R. PMID 31557051 DOI: 10.1096/Fj.201901002R |
0.322 |
|
| 2019 |
Wong EW, Glasgow SD, Trigiani LJ, Chitsaz D, Rymar V, Sadikot A, Ruthazer ES, Hamel E, Kennedy TE. Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain. Learning & Memory (Cold Spring Harbor, N.Y.). 26: 77-83. PMID 30770464 DOI: 10.1101/Lm.049072.118 |
0.325 |
|
| 2019 |
Lecrux C, Bourourou M, Hamel E. How reliable is cerebral blood flow to map changes in neuronal activity? Autonomic Neuroscience : Basic & Clinical. 217: 71-79. PMID 30744905 DOI: 10.1016/J.Autneu.2019.01.005 |
0.348 |
|
| 2019 |
Tong XK, Trigiani LJ, Hamel E. High cholesterol triggers white matter alterations and cognitive deficits in a mouse model of cerebrovascular disease: benefits of simvastatin. Cell Death & Disease. 10: 89. PMID 30692517 DOI: 10.1038/S41419-018-1199-0 |
0.346 |
|
| 2019 |
Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, ... ... Hamel E, et al. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 158-167. PMID 30642436 DOI: 10.1016/J.Jalz.2018.07.222 |
0.357 |
|
| 2018 |
Trigiani LJ, Royea J, Lacalle-Aurioles M, Tong XK, Hamel E. Pleiotropic Benefits of the Angiotensin Receptor Blocker Candesartan in a Mouse Model of Alzheimer Disease. Hypertension (Dallas, Tex. : 1979). 72: 1217-1226. PMID 30354809 DOI: 10.1161/Hypertensionaha.118.11775 |
0.404 |
|
| 2018 |
Cauli B, Hamel E. Brain Perfusion and Astrocytes. Trends in Neurosciences. 41: 409-413. PMID 29933772 DOI: 10.1016/J.Tins.2018.04.010 |
0.322 |
|
| 2017 |
Trigiani LJ, Hamel E. An endothelial link between the benefits of physical exercise in dementia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17714655. PMID 28617071 DOI: 10.1177/0271678X17714655 |
0.329 |
|
| 2017 |
Royea J, Zhang L, Tong XK, Hamel E. Angiotensin IV receptors mediate the cognitive and cerebrovascular benefits of losartan in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28476949 DOI: 10.1523/Jneurosci.0329-17.2017 |
0.413 |
|
| 2017 |
Pakavathkumar P, Noël A, Lecrux C, Tubeleviciute-Aydin A, Hamel E, Ahlfors JE, LeBlanc AC. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Molecular Neurodegeneration. 12: 22. PMID 28241839 DOI: 10.1186/S13024-017-0166-Z |
0.309 |
|
| 2017 |
Naito Y, Tanabe Y, Lee AK, Hamel E, Takahashi H. Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization. Scientific Reports. 7: 42548. PMID 28211900 DOI: 10.1038/Srep42548 |
0.316 |
|
| 2017 |
Lecrux C, Sandoe CH, Neupane S, Kropf P, Toussay X, Tong XK, Lacalle-Aurioles M, Shmuel A, Hamel E. Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28069927 DOI: 10.1523/Jneurosci.1784-16.2016 |
0.388 |
|
| 2017 |
Hamel E. Animal Models: Vascular Models of Cognitive Dysfunction Primer On Cerebrovascular Diseases. 315-319. DOI: 10.1016/B978-0-12-803058-5.00066-7 |
0.364 |
|
| 2016 |
Lecrux C, Hamel E. Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states. Philosophical Transactions of the Royal Society B. 371: 20150350. PMID 27574304 DOI: 10.1098/Rstb.2015.0350 |
0.363 |
|
| 2016 |
Papadopoulos P, Tong XK, Imboden H, Hamel E. Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27389178 DOI: 10.1177/0271678X16658489 |
0.388 |
|
| 2016 |
Badhwar A, Brown R, Stanimirovic DB, Haqqani AS, Hamel E. Proteomic differences in brain vessels of Alzheimer's disease mice: Normalization by PPARγ agonist pioglitazone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27339263 DOI: 10.1177/0271678X16655172 |
0.37 |
|
| 2016 |
Hamel E, Royea J, Ongali B, Tong XK. Neurovascular and Cognitive failure in Alzheimer's Disease: Benefits of Cardiovascular Therapy. Cellular and Molecular Neurobiology. PMID 26993506 DOI: 10.1007/S10571-015-0285-4 |
0.369 |
|
| 2016 |
Ongali B, Nicolakakis N, Tong XK, Aboulkassim T, Imboden H, Hamel E. Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26923013 DOI: 10.3233/Jad-150868 |
0.406 |
|
| 2015 |
Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, ... ... Hamel E, et al. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. The Journal of Experimental Medicine. 212: 1529-49. PMID 26347470 DOI: 10.1084/Jem.20150165 |
0.313 |
|
| 2015 |
Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EM, Tegeder I, Murphy TH, Hamel E, Cauli B. COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11791-810. PMID 26311764 DOI: 10.1523/Jneurosci.0651-15.2015 |
0.387 |
|
| 2015 |
Martins C, H?lková H, Dridi L, Dormoy-Raclet V, Grigoryeva L, Choi Y, Langford-Smith A, Wilkinson FL, Ohmi K, DiCristo G, Hamel E, Ausseil J, Cheillan D, Moreau A, Svobodová E, et al. Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model. Brain : a Journal of Neurology. 138: 336-55. PMID 25567323 DOI: 10.1093/Brain/Awu355 |
0.344 |
|
| 2015 |
Tong XK, Hamel E. Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 512-20. PMID 25564230 DOI: 10.1038/Jcbfm.2014.226 |
0.375 |
|
| 2015 |
Hamel E. Cerebral circulation: function and dysfunction in Alzheimer's disease. Journal of Cardiovascular Pharmacology. 65: 317-24. PMID 25384195 DOI: 10.1097/Fjc.0000000000000177 |
0.332 |
|
| 2015 |
Hamel E. Basic concepts of neuronal control of cerebral blood flow in health and disease Autonomic Neuroscience: Basic and Clinical. 192: 28. DOI: 10.1016/J.Autneu.2015.07.337 |
0.307 |
|
| 2014 |
Gupta A, Lacoste B, Pistell PJ, Pistel PJ, Ingram DK, Hamel E, Alaoui-Jamali MA, Szarek WA, Vlahakis JZ, Jie S, Song W, Schipper HM. Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease. Journal of Neurochemistry. 131: 778-90. PMID 25111043 DOI: 10.1111/Jnc.12927 |
0.64 |
|
| 2014 |
Ongali B, Nicolakakis N, Tong XK, Aboulkassim T, Papadopoulos P, Rosa-Neto P, Lecrux C, Imboden H, Hamel E. Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer's disease model. Neurobiology of Disease. 68: 126-36. PMID 24807206 DOI: 10.1016/J.Nbd.2014.04.018 |
0.401 |
|
| 2014 |
Badhwar A, Stanimirovic DB, Hamel E, Haqqani AS. The proteome of mouse cerebral arteries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1033-46. PMID 24667914 DOI: 10.1038/Jcbfm.2014.52 |
0.31 |
|
| 2014 |
LeBlanc AC, Ramcharitar J, Afonso V, Hamel E, Bennett DA, Pakavathkumar P, Albrecht S. Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. Cell Death and Differentiation. 21: 696-706. PMID 24413155 DOI: 10.1038/Cdd.2013.194 |
0.314 |
|
| 2014 |
Papadopoulos P, Tong XK, Hamel E. Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice. Neurobiology of Aging. 35: 203-12. PMID 23954171 DOI: 10.1016/J.Neurobiolaging.2013.07.010 |
0.366 |
|
| 2013 |
Badhwar A, Lerch JP, Hamel E, Sled JG. Impaired structural correlates of memory in Alzheimer's disease mice. Neuroimage. Clinical. 3: 290-300. PMID 24273714 DOI: 10.1016/J.Nicl.2013.08.017 |
0.338 |
|
| 2013 |
Zhang L, Papadopoulos P, Hamel E. Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease. British Journal of Pharmacology. 170: 661-70. PMID 23889563 DOI: 10.1111/Bph.12315 |
0.359 |
|
| 2013 |
Papadopoulos P, Rosa-Neto P, Rochford J, Hamel E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology. Plos One. 8: e68612. PMID 23874687 DOI: 10.1371/Journal.Pone.0068612 |
0.404 |
|
| 2013 |
Lacoste B, Tong XK, Lahjouji K, Couture R, Hamel E. Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice. Journal of Neuroinflammation. 10: 57. PMID 23642031 DOI: 10.1186/1742-2094-10-57 |
0.684 |
|
| 2013 |
Grand'maison M, Zehntner SP, Ho MK, Hébert F, Wood A, Carbonell F, Zijdenbos AP, Hamel E, Bedell BJ. Early cortical thickness changes predict β-amyloid deposition in a mouse model of Alzheimer's disease. Neurobiology of Disease. 54: 59-67. PMID 23454197 DOI: 10.1016/J.Nbd.2013.02.005 |
0.356 |
|
| 2013 |
Toussay X, Basu K, Lacoste B, Hamel E. Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3390-401. PMID 23426667 DOI: 10.1523/Jneurosci.3346-12.2013 |
0.649 |
|
| 2013 |
Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, et al. DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Reports. 3: 173-85. PMID 23291093 DOI: 10.1016/J.Celrep.2012.12.005 |
0.325 |
|
| 2013 |
Hébert F, Grand'maison M, Ho MK, Lerch JP, Hamel E, Bedell BJ. Cortical atrophy and hypoperfusion in a transgenic mouse model of Alzheimer's disease. Neurobiology of Aging. 34: 1644-52. PMID 23273599 DOI: 10.1016/J.Neurobiolaging.2012.11.022 |
0.358 |
|
| 2012 |
Song W, Zukor H, Lin SH, Hascalovici J, Liberman A, Tavitian A, Mui J, Vali H, Tong XK, Bhardwaj SK, Srivastava LK, Hamel E, Schipper HM. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10841-53. PMID 22875919 DOI: 10.1523/Jneurosci.6469-11.2012 |
0.334 |
|
| 2012 |
Tong XK, Lecrux C, Rosa-Neto P, Hamel E. Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4705-15. PMID 22492027 DOI: 10.1523/Jneurosci.0169-12.2012 |
0.404 |
|
| 2012 |
Lecrux C, Kocharyan A, Sandoe CH, Tong XK, Hamel E. Pyramidal cells and cytochrome P450 epoxygenase products in the neurovascular coupling response to basal forebrain cholinergic input. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 896-906. PMID 22293985 DOI: 10.1038/Jcbfm.2012.4 |
0.368 |
|
| 2012 |
Badhwar A, Stanimirovic D, Haqqani A, Hamel E. P4-041: Quantitative proteomics of Alzheimer's-like cerebral vasculature in TGF-ß1 overexpressing mice and its perturbation by pioglitazone Alzheimer's & Dementia. 8: P650-P650. DOI: 10.1016/J.Jalz.2012.05.1742 |
0.348 |
|
| 2012 |
Badhwar A, Brown R, Delaney C, Stanimirovic D, Haqqani A, Hamel E. P3-332: Rescue of beta-amyloid-induced alterations in cerebrovascular protein expression by pioglitazone in APP mice: Link to functional recovery in the cerebrovasculature Alzheimer's & Dementia. 8: P574-P575. DOI: 10.1016/J.Jalz.2012.05.1556 |
0.312 |
|
| 2011 |
Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Lévesque M, Plaisier F, Shmuel A, Cauli B, Hamel E. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9836-47. PMID 21734275 DOI: 10.1523/Jneurosci.4943-10.2011 |
0.362 |
|
| 2011 |
Aboulkassim T, Tong XK, Tse YC, Wong TP, Woo SB, Neet KE, Brahimi F, Hamel E, Saragovi HU. Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory. Molecular Pharmacology. 80: 498-508. PMID 21616921 DOI: 10.1124/Mol.111.071332 |
0.339 |
|
| 2011 |
Nicolakakis N, Hamel E. Neurovascular function in Alzheimer's disease patients and experimental models. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1354-70. PMID 21468088 DOI: 10.1038/Jcbfm.2011.43 |
0.376 |
|
| 2011 |
Lecrux C, Hamel E. The neurovascular unit in brain function and disease. Acta Physiologica (Oxford, England). 203: 47-59. PMID 21272266 DOI: 10.1111/J.1748-1716.2011.02256.X |
0.345 |
|
| 2011 |
Drouin A, Bolduc V, Thorin-Trescases N, Bélanger É, Fernandes P, Baraghis E, Lesage F, Gillis MA, Villeneuve L, Hamel E, Ferland G, Thorin E. Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1032-43. PMID 21186270 DOI: 10.1152/Ajpheart.00410.2010 |
0.35 |
|
| 2011 |
Nicolakakis N, Aboulkassim T, Aliaga A, Tong XK, Rosa-Neto P, Hamel E. Intact memory in TGF-β1 transgenic mice featuring chronic cerebrovascular deficit: recovery with pioglitazone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 200-11. PMID 20571524 DOI: 10.1038/Jcbfm.2010.78 |
0.356 |
|
| 2011 |
Hebert F, Ho M, Lerch J, Hamel E, Bedell B. P4-356: MRI-derived cortical thickness measurements from APP transgenic mice Alzheimer's & Dementia. 7: e36-e36. DOI: 10.1016/J.Jalz.2011.09.101 |
0.304 |
|
| 2011 |
Lacoste B, Tong X, Lahjouji K, Couture R, Hamel E. O3-07-02: Bradykinin B1 receptor blockade in the treatment of Alzheimer's disease: improvement of cognitive and cerebrovascular functions and reduction of amyloidosis Alzheimer's & Dementia. 7: S512-S513. DOI: 10.1016/J.Jalz.2011.05.1433 |
0.622 |
|
| 2010 |
Ongali B, Nicolakakis N, Lecrux C, Aboulkassim T, Rosa-Neto P, Papadopoulos P, Tong XK, Hamel E. Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. The American Journal of Pathology. 177: 3071-80. PMID 21088218 DOI: 10.2353/Ajpath.2010.100339 |
0.392 |
|
| 2010 |
Seyrantepe V, Lema P, Caqueret A, Dridi L, Bel Hadj S, Carpentier S, Boucher F, Levade T, Carmant L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud JL, Morales CR, et al. Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. Plos Genetics. 6: e1001118. PMID 20862357 DOI: 10.1371/Journal.Pgen.1001118 |
0.338 |
|
| 2010 |
Nicolakakis N, Hamel E. The Nuclear Receptor PPARgamma as a Therapeutic Target for Cerebrovascular and Brain Dysfunction in Alzheimer's Disease. Frontiers in Aging Neuroscience. 2. PMID 20725514 DOI: 10.3389/Fnagi.2010.00021 |
0.382 |
|
| 2010 |
Cauli B, Hamel E. Revisiting the role of neurons in neurovascular coupling. Frontiers in Neuroenergetics. 2: 9. PMID 20616884 DOI: 10.3389/Fnene.2010.00009 |
0.335 |
|
| 2009 |
Saragovi HU, Hamel E, Di Polo A. A neurotrophic rationale for the therapy of neurodegenerative disorders. Current Alzheimer Research. 6: 419-23. PMID 19874265 DOI: 10.2174/156720509789207912 |
0.31 |
|
| 2009 |
Tong XK, Nicolakakis N, Fernandes P, Ongali B, Brouillette J, Quirion R, Hamel E. Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice. Neurobiology of Disease. 35: 406-14. PMID 19524673 DOI: 10.1016/J.Nbd.2009.06.003 |
0.397 |
|
| 2009 |
Enager P, Piilgaard H, Offenhauser N, Kocharyan A, Fernandes P, Hamel E, Lauritzen M. Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 976-86. PMID 19337274 DOI: 10.1038/Jcbfm.2009.23 |
0.37 |
|
| 2009 |
Badhwar A, Chakravarty M, Zehntner S, Hamel E, Bedell B. Automated quantification of vascular and parenchymal beta-amyloid burdens in a transgenic mouse model of Alzheimer's disease Journal of the Neurological Sciences. 283: 253. DOI: 10.1016/J.Jns.2009.02.058 |
0.321 |
|
| 2009 |
Ongali B, Nicolakakis N, Lecrux C, Aboulkassim T, Fernandes P, Tong X, Hamel E. P4-043: Cerebrovascular and memory deficits in an Alzheimer's disease mouse model overexpressing amyloid precursor protein and transforming growth factor-β1 Alzheimer's & Dementia. 5: P444-P444. DOI: 10.1016/J.Jalz.2009.04.913 |
0.302 |
|
| 2008 |
Nicolakakis N, Aboulkassim T, Ongali B, Lecrux C, Fernandes P, Rosa-Neto P, Tong XK, Hamel E. Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9287-96. PMID 18784309 DOI: 10.1523/Jneurosci.3348-08.2008 |
0.445 |
|
| 2008 |
Sakai Y, Dobson C, Diksic M, Aubé M, Hamel E. Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis Neurology. 70: 431-439. PMID 18250288 DOI: 10.1212/01.Wnl.0000299095.65331.6F |
0.31 |
|
| 2008 |
Kocharyan A, Fernandes P, Tong XK, Vaucher E, Hamel E. Specific subtypes of cortical GABA interneurons contribute to the neurovascular coupling response to basal forebrain stimulation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 221-31. PMID 17895909 DOI: 10.1038/Sj.Jcbfm.9600558 |
0.336 |
|
| 2007 |
Tong XK, Hamel E. Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase. Molecular Pharmacology. 72: 1476-83. PMID 17848599 DOI: 10.1124/Mol.107.039602 |
0.378 |
|
| 2007 |
Drouin A, Thorin-Trescases N, Hamel E, Falck JR, Thorin E. Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries. Cardiovascular Research. 73: 73-81. PMID 17113574 DOI: 10.1016/J.Cardiores.2006.10.005 |
0.323 |
|
| 2006 |
Rancillac A, Rossier J, Guille M, Tong XK, Geoffroy H, Amatore C, Arbault S, Hamel E, Cauli B. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6997-7006. PMID 16807329 DOI: 10.1523/Jneurosci.5515-05.2006 |
0.385 |
|
| 2006 |
Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. Journal of Applied Physiology (Bethesda, Md. : 1985). 100: 1059-64. PMID 16467392 DOI: 10.1152/Japplphysiol.00954.2005 |
0.341 |
|
| 2006 |
Choi JK, Chen YI, Hamel E, Jenkins BG. Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage. 30: 700-12. PMID 16459104 DOI: 10.1016/J.Neuroimage.2005.10.029 |
0.307 |
|
| 2005 |
Tong XK, Nicolakakis N, Kocharyan A, Hamel E. Vascular remodeling versus amyloid beta-induced oxidative stress in the cerebrovascular dysfunctions associated with Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11165-74. PMID 16319316 DOI: 10.1523/Jneurosci.4031-05.2005 |
0.396 |
|
| 2005 |
Aucoin JS, Jiang P, Aznavour N, Tong XK, Buttini M, Descarries L, Hamel E. Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease. Neuroscience. 132: 73-86. PMID 15780468 DOI: 10.1016/J.Neuroscience.2004.11.047 |
0.619 |
|
| 2005 |
Descarries L, Aznavour N, Hamel E. The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPP(SW,IND) mouse model of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 149-62. PMID 15599613 DOI: 10.1007/S00702-004-0186-Z |
0.62 |
|
| 2005 |
Tong X, Nicolakakis N, Hamel E. Vascular fibrosis versus amyloid beta (A|[szlig]|)-induced oxidative stress in the cerebrovascular pathology associated with Alzheimer|[rsquo]|s disease (AD) Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0173 |
0.328 |
|
| 2005 |
Kocharyan A, Fernandes P, Serluca N, Vaucher E, Hamel E. Chemical or electrical stimulation of basal forebrain neurons activates specific subsets of cortical GABA-interneurons in parallel with increases in cortical cerebral blood flow Journal of Cerebral Blood Flow & Metabolism. 25: S159-S159. DOI: 10.1038/Sj.Jcbfm.9591524.0159 |
0.339 |
|
| 2005 |
Nicolakakis N, Tong X, Hamel E. Reversal of fully developed cerebrovascular dysfunctions in two transgenic mouse models of Alzheimer's disease Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0157 |
0.321 |
|
| 2004 |
Cauli B, Tong XK, Rancillac A, Serluca N, Lambolez B, Rossier J, Hamel E. Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8940-9. PMID 15483113 DOI: 10.1523/Jneurosci.3065-04.2004 |
0.388 |
|
| 2004 |
Dobson C, Tohyama Y, Diksic M, Hamel E. Effects of acute or chronic administration of anti‐migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain Cephalalgia. 24: 2-11. PMID 14687006 DOI: 10.1111/J.1468-2982.2004.00647.X |
0.312 |
|
| 2004 |
Hamel E. Cholinergic modulation of the cortical microvascular bed. Progress in Brain Research. 145: 171-8. PMID 14650915 DOI: 10.1016/S0079-6123(03)45012-7 |
0.377 |
|
| 2002 |
Férézou I, Cauli B, Hill EL, Rossier J, Hamel E, Lambolez B. 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7389-97. PMID 12196560 DOI: 10.1523/Jneurosci.22-17-07389.2002 |
0.365 |
|
| 2002 |
Moreno MJ, Abounader R, Hébert E, Doods H, Hamel E. Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment. Neuropharmacology. 42: 568-76. PMID 11955527 DOI: 10.1016/S0028-3908(02)00008-4 |
0.347 |
|
| 2002 |
Moreno MJ, Terrón JA, Stanimirovic DB, Doods H, Hamel E. Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture. Neuropharmacology. 42: 270-80. PMID 11804624 DOI: 10.1016/S0028-3908(01)00176-9 |
0.331 |
|
| 2001 |
Elhusseiny A, Hamel E. Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles British Journal of Pharmacology. 132: 55-62. PMID 11156561 DOI: 10.1038/Sj.Bjp.0703763 |
0.356 |
|
| 2000 |
Vaucher E, Tong XK, Cholet N, Lantin S, Hamel E. GABA neurons provide a rich input to microvessels but not nitric oxide neurons in the rat cerebral cortex: a means for direct regulation of local cerebral blood flow. The Journal of Comparative Neurology. 421: 161-71. PMID 10813779 DOI: 10.1002/(Sici)1096-9861(20000529)421:2<161::Aid-Cne3>3.0.Co;2-F |
0.367 |
|
| 2000 |
Tomita M, Suzuki N, Hamel E, Busija D, Lauritzen M. Regulation of cerebral microcirculation--update. The Keio Journal of Medicine. 49: 26-34. PMID 10750378 DOI: 10.2302/Kjm.49.26 |
0.381 |
|
| 2000 |
Dumont Y, Cadieux A, Doods H, Pheng LH, Abounader R, Hamel E, Jacques D, Regoli D, Quirion R. BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. British Journal of Pharmacology. 129: 1075-88. PMID 10725255 DOI: 10.1038/Sj.Bjp.0703162 |
0.327 |
|
| 2000 |
Bouchelet I, Case B, Olivier A, Hamel E. No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries: similarity with human coronary artery. British Journal of Pharmacology. 129: 501-508. PMID 10711348 DOI: 10.1038/Sj.Bjp.0703081 |
0.321 |
|
| 2000 |
Ishine T, Bouchelet I, Hamel E, Lee TJF. Serotonin 5-HT7 receptors mediate relaxation of porcine pial veins American Journal of Physiology-Heart and Circulatory Physiology. 278. PMID 10710360 DOI: 10.1152/Ajpheart.2000.278.3.H907 |
0.304 |
|
| 2000 |
Elhusseiny A, Hamel E. Muscarinic—but Not Nicotinic—Acetylcholine Receptors Mediate a Nitric Oxide-Dependent Dilation in Brain Cortical Arterioles: A Possible Role for the M5 Receptor Subtype Journal of Cerebral Blood Flow and Metabolism. 20: 298-305. PMID 10698067 DOI: 10.1097/00004647-200002000-00011 |
0.311 |
|
| 1999 |
Moreno MJ, Cohen Z, Stanimirovic DB, Hamel E. Functional calcitonin gene-related peptide type 1 and adrenomedullin receptors in human trigeminal ganglia, brain vessels, and cerebromicrovascular or astroglial cells in culture. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 1270-8. PMID 10566974 DOI: 10.1097/00004647-199911000-00012 |
0.353 |
|
| 1999 |
Hamel E. The biology of serotonin receptors: focus on migraine pathophysiology and treatment. Canadian Journal of Neurological Sciences. 26: 2-6. PMID 10563226 DOI: 10.1017/S0317167100000123 |
0.32 |
|
| 1999 |
Cohen Z, Bouchelet I, Olivier A, Villemure JG, Ball R, Stanimirovic DB, Hamel E. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 908-17. PMID 10458598 DOI: 10.1097/00004647-199908000-00010 |
0.37 |
|
| 1999 |
Elhusseiny A, Cohen Z, Olivier A, Stanimirović DB, Hamel E. Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 794-802. PMID 10413035 DOI: 10.1097/00004647-199907000-00010 |
0.354 |
|
| 1999 |
Tong XK, Hamel E. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience. 92: 163-175. PMID 10392839 DOI: 10.1016/S0306-4522(98)00750-7 |
0.423 |
|
| 1999 |
Ljubic‐Thibal V, Morin A, Diksic M, Hamel E. Origin of the serotonergic innervation to the rat dorsolateral hypothalamus: retrograde transport of cholera toxin and upregulation of tryptophan hydroxylase mRNA expression following selective nerve terminals lesion. Synapse. 32: 177-186. PMID 10340628 DOI: 10.1002/(Sici)1098-2396(19990601)32:3<177::Aid-Syn4>3.0.Co;2-D |
0.338 |
|
| 1999 |
Abounader R, Elhusseiny A, Cohen Z, Olivier A, Stanimirovic D, Quirion R, Hamel E. Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 155-63. PMID 10027771 DOI: 10.1097/00004647-199902000-00007 |
0.326 |
|
| 1998 |
Riad M, Tong XK, el Mestikawy S, Hamon M, Hamel E, Descarries L. Endothelial expression of the 5-hydroxytryptamine1B antimigraine drug receptor in rat and human brain microvessels. Neuroscience. 86: 1031-5. PMID 9697110 DOI: 10.1016/S0306-4522(98)00196-1 |
0.615 |
|
| 1998 |
St-Pierre JA, Dumont Y, Nouel D, Herzog H, Hamel E, Quirion R. Preferential expression of the neuropeptide Y Y1 over the Y2 receptor subtype in cultured hippocampal neurons and cloning of the rat Y2 receptor. British Journal of Pharmacology. 123: 183-94. PMID 9489605 DOI: 10.1038/Sj.Bjp.0701589 |
0.344 |
|
| 1998 |
Petty MA, Elands J, Johnson MP, Linnik MD, Hamel E, Moskowitz MA, Lee WS, McCarty DR, Hibert M, Baron BM. The selectivity of MDL 74,721 in models of neurogenic versus vascular components of migraine. European Journal of Pharmacology. 336: 127-36. PMID 9384224 DOI: 10.1016/S0014-2999(97)01218-1 |
0.355 |
|
| 1997 |
Abounader R, Hamel E. Associations between neuropeptide Y nerve terminals and intraparenchymal microvessels in rat and human cerebral cortex The Journal of Comparative Neurology. 388: 444-453. PMID 9368852 DOI: 10.1002/(Sici)1096-9861(19971124)388:3<444::Aid-Cne7>3.0.Co;2-0 |
0.389 |
|
| 1997 |
Cohen Z, Molinatti G, Hamel E. Astroglial and Vascular Interactions of Noradrenaline Terminals in the Rat Cerebral Cortex Journal of Cerebral Blood Flow and Metabolism. 17: 894-904. PMID 9290587 DOI: 10.1097/00004647-199708000-00008 |
0.352 |
|
| 1997 |
Vaucher E, Linville D, Hamel E. Cholinergic basal forebrain projections to nitric oxide synthase- containing neurons in the rat cerebral cortex Neuroscience. 79: 827-836. PMID 9219945 DOI: 10.1016/S0306-4522(97)00033-X |
0.357 |
|
| 1997 |
Linville DG, Hamel E. Acetylcholine and Its Receptors Primer On Cerebrovascular Diseases. 82-85. DOI: 10.1016/B978-012743170-3.50024-8 |
0.412 |
|
| 1996 |
Cohen Z, Bonvento G, Lacombe P, Hamel E. Serotonin In The Regulation Of Brain Microcirculation Progress in Neurobiology. 50: 335-362. PMID 9004349 DOI: 10.1016/S0301-0082(96)00033-0 |
0.365 |
|
| 1996 |
Ljubić-Thibal V, Diksic M, Hamel E, Raison S, Pujol JF, Weissmann D. Ipsilateral alterations in tryptophan hydroxylase activity in rat brain after hypothalamic 5,7-di-hydroxytryptamine lesion. Brain Research. 724: 222-31. PMID 8828572 DOI: 10.1016/0006-8993(96)00327-7 |
0.304 |
|
| 1995 |
Abounader R, Villemure J, Hamel E. Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226. British Journal of Pharmacology. 116: 2245-2250. PMID 8564255 DOI: 10.1111/J.1476-5381.1995.Tb15060.X |
0.352 |
|
| 1995 |
Cohen Z, Tsuiki K, Takada A, Beaudet A, Diksic M, Hamel E. In vivo-synthesized radioactively labelled α-methyl serotonin as a selective tracer for visualization of brain serotonin neurons Synapse. 21: 21-28. PMID 8525458 DOI: 10.1002/Syn.890210104 |
0.318 |
|
| 1995 |
Linville DG, Hamel E. Pharmacological characterization of muscarinic acetylcholine binding sites in human and bovine cerebral microvessels Naunyn-Schmiedeberg's Archives of Pharmacology. 352: 179-186. PMID 7477441 DOI: 10.1007/Bf00176772 |
0.316 |
|
| 1995 |
Vaucher E, Hamel E. Cholinergic basal forebrain neurons project to cortical microvessels in the rat: electron microscopic study with anterogradely transported Phaseolus vulgaris leucoagglutinin and choline acetyltransferase immunocytochemistry The Journal of Neuroscience. 15: 7427-7441. DOI: 10.1523/Jneurosci.15-11-07427.1995 |
0.349 |
|
| 1994 |
Chédotal A, Cozzari C, Faure MP, Hartman BK, Hamel E. Distinct choline acetyltransferase (ChAT) and vasoactive intestinal polypeptide (VIP) bipolar neurons project to local blood vessels in the rat cerebral cortex. Brain Research. 646: 181-93. PMID 8069662 DOI: 10.1016/0006-8993(94)90076-0 |
0.621 |
|
| 1994 |
Dauphin F, Linville DG, Hamel E. Cholinergic dilatation and constriction of feline cerebral blood vessels are mediated by stimulation of phosphoinositide metabolism via two different muscarinic receptor subtypes. Journal of Neurochemistry. 63: 544-51. PMID 8035178 DOI: 10.1046/J.1471-4159.1994.63020544.X |
0.347 |
|
| 1994 |
Chédotal A, Umbriaco D, Descarries L, Hartman BK, Hamel E. Light and electron microscopic immunocytochemical analysis of the neurovascular relationships of choline acetyltransferase and vasoactive intestinal polypeptide nerve terminals in the rat cerebral cortex. The Journal of Comparative Neurology. 343: 57-71. PMID 8027437 DOI: 10.1002/Cne.903430105 |
0.705 |
|
| 1993 |
Hamel E, Grégoire L, Lau B. 5-HT1 receptors mediating contraction in bovine cerebral arteries: a model for human cerebrovascular '5-HT1Dβ' receptors European Journal of Pharmacology. 242: 75-82. PMID 8223939 DOI: 10.1016/0014-2999(93)90012-7 |
0.327 |
|
| 1993 |
Cossette P, Umbriaco D, Zamar N, Hamel E, Descarries L. Recovery of choline acetyltransferase activity without sprouting of the residual acetylcholine innervation in adult rat cerebral cortex after lesion of the nucleus basalis. Brain Research. 630: 195-206. PMID 8118686 DOI: 10.1016/0006-8993(93)90657-9 |
0.584 |
|
| 1993 |
Hasséssian H, Poulat P, Hamel E, Reader TA, Couture R. Spinal cord serotonin receptors in cardiovascular regulation and potentiation of the pressor response to intrathecal substance P after serotonin depletion. Canadian Journal of Physiology and Pharmacology. 71: 453-64. PMID 7694781 DOI: 10.1139/Y93-067 |
0.303 |
|
| 1992 |
Cohen Z, Bovento G, Lacombe P, Seylaz J, MacKenzie ET, Hamel E. Cerebrovascular nerve fibers immunoreactive for tryptophan-5-hydroxylase in the rat: distribution, putative origin and comparison with sympathetic noradrenergic nerves. Brain Research. 598: 203-14. PMID 1486481 DOI: 10.1016/0006-8993(92)90184-B |
0.321 |
|
| 1992 |
Giguère JF, Hamel E, Butterworth RF. Increased densities of binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 in rat brain following portacaval anastomosis. Brain Research. 585: 295-8. PMID 1324770 DOI: 10.1016/0006-8993(92)91222-Z |
0.319 |
|
| 1991 |
Dauphin F, Richard JW, Seylaz J, Quirion R, Hamel E. Acetylcholine levels and choline acetyltransferase activity in rat cerebrovascular bed after uni- or bilateral sphenopalatine ganglionectomy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11: 253-60. PMID 1997497 DOI: 10.1038/Jcbfm.1991.57 |
0.351 |
|
| 1991 |
Dauphin F, Lacombe P, Sercombe R, Hamel E, Seylaz J. Hypercapnia and stimulation of the substantia innominata increase rat frontal cortical blood flow by different cholinergic mechanisms. Brain Research. 553: 75-83. PMID 1933278 DOI: 10.1016/0006-8993(91)90232-K |
0.312 |
|
| 1991 |
Dauphin F, Ting V, Payette P, Dennis M, Hamel E. Vasocontractile muscarinic M1 receptors in cat cerebral arteries: pharmacological identification and detection of mRNA. European Journal of Pharmacology. 207: 319-27. PMID 1783002 DOI: 10.1016/0922-4106(91)90006-4 |
0.331 |
|
| 1990 |
Hamel E, Assumel Lurdin C, Fage D, Edvinsson L, MacKenzie ET. Small pial vessels, but not choroid plexus, exhibit specific biochemical correlates of functional cholinergic innervation. Brain Research. 516: 301-9. PMID 2364295 DOI: 10.1016/0006-8993(90)90931-Z |
0.359 |
|
| 1990 |
Dauphin F, Hamel E. Muscarinic receptor subtype mediating vasodilation feline middle cerebral artery exhibits M3 pharmacology. European Journal of Pharmacology. 178: 203-13. PMID 2328761 DOI: 10.1016/0014-2999(90)90476-M |
0.338 |
|
| 1990 |
González C, Martin C, Hamel E, Galea E, Gómez B, Lluch S, Estrada C. Endothelial cells inhibit the vascular response to adrenergic nerve stimulation by a receptor-mediated mechanism Canadian Journal of Physiology and Pharmacology. 68: 104-109. PMID 2328438 DOI: 10.1139/Y90-016 |
0.339 |
|
| 1990 |
Chédotal A, Hamel E. Serotonin-synthesizing nerve fibers in rat and cat cerebral arteries and arterioles: immunohistochemistry of tryptophan-5-hydroxylase. Neuroscience Letters. 116: 269-74. PMID 2243604 DOI: 10.1016/0304-3940(90)90085-N |
0.589 |
|
| 1990 |
Hamel E, Assumel-Lurdin C, Bouloy M, MacKenzie ET. Selective age-related changes in neuronal markers and smooth muscle reactivity in cerebrovascular beds of Fischer 344 rats. Neurobiology of Aging. 11: 631-9. PMID 1980721 DOI: 10.1016/0197-4580(90)90029-Y |
0.327 |
|
| 1989 |
Hara H, Jansen I, Ekman R, Hamel E, MacKenzie ET, Uddman R, Edvinsson L. Acetylcholine and vasoactive intestinal peptide in cerebral blood vessels: effect of extirpation of the sphenopalatine ganglion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 9: 204-11. PMID 2921295 DOI: 10.1038/Jcbfm.1989.30 |
0.367 |
|
| 1989 |
Kiyosawa M, Baron JC, Hamel E, Pappata S, Duverger D, Riche D, Mazoyer B, Naquet R, MacKenzie ET. Time course of effects of unilateral lesions of the nucleus basalis of Meynert on glucose utilization by the cerebral cortex. Positron tomography in baboons. Brain : a Journal of Neurology. 112: 435-55. PMID 2784988 DOI: 10.1093/Brain/112.2.435 |
0.318 |
|
| 1988 |
Hamel E, Edvinsson L, MacKenzie ET. Heterogeneous vasomotor responses of anatomically distinct feline cerebral arteries. British Journal of Pharmacology. 94: 423-36. PMID 3395784 DOI: 10.1111/J.1476-5381.1988.Tb11544.X |
0.31 |
|
| 1987 |
Hamel E, Assumel-Lurdin C, Edvinsson L, Fage D, MacKenzie ET. Neuronal versus endothelial origin of vasoactive acetylcholine in pial vessels. Brain Research. 420: 391-6. PMID 3676771 DOI: 10.1016/0006-8993(87)91263-7 |
0.344 |
|
| 1987 |
Hamel E, Beaudet A. Opioid receptors in rat neostriatum: radioautographic distribution at the electron microscopic level Brain Research. 401: 239-257. PMID 3028575 DOI: 10.1016/0006-8993(87)91409-0 |
0.309 |
|
| 1985 |
Edvinsson L, Fredholm BB, Hamel E, Jansen I, Verrecchia C. Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neuroscience Letters. 58: 213-7. PMID 2995876 DOI: 10.1016/0304-3940(85)90166-1 |
0.328 |
|
| 1984 |
Hamel E, Beaudet A. Electron microscopic autoradiographic localization of opioid receptors in rat neostriatum. Nature. 312: 155-157. PMID 6095083 DOI: 10.1038/312155A0 |
0.305 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2001 |
Terrón JA, Bouchelet I, Hamel E. 5-HT7 receptor mRNA expression in human trigeminal ganglia. Neuroscience Letters. 302: 9-12. PMID 11278099 DOI: 10.1016/S0304-3940(01)01617-2 |
0.299 |
|
| 2008 |
Curtis JS, Cakiroglu HJ, Zehntner S, Hamel E, Bedell BJ. IC-P1-013: 3D whole-brain perfusion MRI in APP transgenic mice Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.025 |
0.298 |
|
| 2009 |
Tong X, Nicolakakis N, Fernandes P, Ongali B, Brouillette J, Quirion R, Hamel E. Simvastatin improves cerebrovascular function and reduces soluble amyloid-beta, inflammation and oxidative stress in aged APP mice Alzheimers & Dementia. 5: 331. DOI: 10.1016/J.Jalz.2009.04.555 |
0.298 |
|
| 2010 |
Badhwar A, Lerch JP, Sled JG, Hamel E. IC-P-001: Early treatment with pioglitazone in APP transgenic mice shows focal hippocampal volume increase related to improved cognitive performance Alzheimer's & Dementia. 6: S5-S6. DOI: 10.1016/J.Jalz.2010.05.016 |
0.298 |
|
| 2005 |
Rancillac A, Guille M, Tong X, Geoffroy H, Arbault S, Hamel E, Amatore C, Rossier J, Cauli B. Stellate cells release NO and induce vasodilation of intraparenchymal blood vessels in rat cerebellar slices Journal of Cerebral Blood Flow & Metabolism. 25: S168-S168. DOI: 10.1038/Sj.Jcbfm.9591524.0168 |
0.297 |
|
| 2007 |
Hamel E. Serotonin and migraine: Biology and clinical implications Cephalalgia. 27: 1295-1300. PMID 17970989 DOI: 10.1111/J.1468-2982.2007.01476.X |
0.291 |
|
| 2007 |
Lau JC, Lerch JP, Zehntner SP, Hamel E, Evans AC, Bedell BJ. P-043: Identifying the trajectory of disease in APP/PS1 mice using automated deformation-based analysis with manual validation Alzheimer's & Dementia. 3: S111-S111. DOI: 10.1016/J.Jalz.2007.04.259 |
0.286 |
|
| 1991 |
Hamel E, Bouchard D. Contractile 5-HT1 receptors in human isolated pial arterioles: Correlation with 5-HT(1D) binding sites British Journal of Pharmacology. 102: 227-233. PMID 2043924 DOI: 10.1111/J.1476-5381.1991.Tb12158.X |
0.286 |
|
| 1980 |
Butterworth RF, Landreville F, Hamel E, Merkel A, Giguere F, Barbeau A. Effect of Asparagine, Glutamine and Insulin on Cerebral Amino Acid Neurotransmitters Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 7: 447-450. PMID 6111388 DOI: 10.1017/S0317167100023040 |
0.283 |
|
| 1984 |
Hamel E, Beaudet A. Localization of opioid binding sites in rat brain by electron microscopic radioautography Journal of Electron Microscopy Technique. 1: 317-329. DOI: 10.1002/Jemt.1060010402 |
0.282 |
|
| 1979 |
Butterworth RF, Hamel E, Landreville F, Barbeau A. Amino acid changes in thiamine-deficient encephalopathy: some implications for the pathogenesis of Friedreich's ataxia. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 6: 217-22. PMID 487314 DOI: 10.1017/S0317167100119675 |
0.282 |
|
| 1978 |
Butterworth RF, Hamel E, Landreville F, Barbeau A. Cerebellar Ataxia Produced by 3-Acetyl Pyridine in Rat Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 5: 131-133. DOI: 10.1017/S0317167100024914 |
0.281 |
|
| 2006 |
Guille M, Rancillac A, Geoffroy H, Tong X, Hamel E, Amatore C, Rossier J, Arbault S, Cauli B. P018. Monitoring NO release by a single stellate cell in a rat cerebellar slice: Study of the neuro-vascular coupling Nitric Oxide. 14: 22-23. DOI: 10.1016/J.Niox.2006.04.077 |
0.28 |
|
| 2013 |
Martins C, Dormoy-Raclet V, Bruno L, Dridi L, Cristo GD, Hamel E, Pshezhetsky A. Evaluation of brain inflammation and cognitive abilities in the mouse model of MPS IIIC Molecular Genetics and Metabolism. 108. DOI: 10.1016/J.Ymgme.2012.11.162 |
0.28 |
|
| 1979 |
Hamel E, Butterworth RF, Barbeau A. Effect of thiamine deficiency on levels of putative amino acid transmitters in affected regions of the rat brain. Journal of Neurochemistry. 33: 575-7. PMID 38303 DOI: 10.1111/J.1471-4159.1979.Tb05191.X |
0.279 |
|
| 2007 |
Chakravarty MM, Bedell BJ, Zehntner SP, Hemmings K, Hamel E, Evans AC, Collins DL. P-105: Three-dimensional reconstruction of histological sections and correlations with MRI from transgenic models of Alzheimer's disease Alzheimer's & Dementia. 3: S132-S132. DOI: 10.1016/J.Jalz.2007.04.169 |
0.278 |
|
| 2003 |
Pringsheim T, Diksic M, Dobson C, Nguyen K, Hamel E. Selective Decrease in Serotonin Synthesis Rate in Rat Brainstem Raphe Nuclei Following Chronic Administration of Low Doses of Amitriptyline: an Effect Compatible with an Anti-Migraine Effect Cephalalgia. 23: 367-375. PMID 12780767 DOI: 10.1046/J.1468-2982.2003.00526.X |
0.276 |
|
| 1983 |
Estrada C, Hamel E, Krause DN. Biochemical evidence for cholinergic innervation of intracerebral blood vessels Brain Research. 266: 261-270. PMID 6135491 DOI: 10.1016/0006-8993(83)90657-1 |
0.275 |
|
| 1997 |
Stanimirovic D, Morley P, Ball R, Hamel E, Mealing G, Durkin JP. Angiotensin II-induced fluid phase endocytosis in human cerebromicrovascular endothelial cells is regulated by the inositol-phosphate signaling pathway. Journal of Cellular Physiology. 169: 455-67. PMID 8952695 DOI: 10.1002/(Sici)1097-4652(199612)169:3<455::Aid-Jcp6>3.0.Co;2-N |
0.275 |
|
| 2007 |
Chakravarty MM, Collins DL, Zehntner SP, Hemmings K, Chan C, Zijdenbos AP, Hamel E, Evans AC, Bedell BJ. O2-01-05: Ex vivo molecular imaging in transgenic mouse models of Alzheimer's disease Alzheimer's & Dementia. 3: S183-S183. DOI: 10.1016/J.Jalz.2007.04.048 |
0.275 |
|
| 2010 |
Bedell BJ, Cakiroglu J, Ella A, Hebert F, Ho M, Yu J, Hamel E. Arterial Spin Labeling Perfusion Magnetic Resonance Imaging of Aged Amyloid Precursor Protein Transgenic Mice Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.08.105 |
0.274 |
|
| 2011 |
Hebert F, Ho M, Hamel E, Bedell B. Neuroanatomical volumes from MRI studies of young, middle-aged, and old APP transgenic mice Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.892 |
0.273 |
|
| 2021 |
Trigiani LJ, Bourourou M, Lacalle-Aurioles M, Lecrux C, Hynes A, Spring S, Fernandes DJ, Sled JG, Lesage F, Schwaninger M, Hamel E. A functional cerebral endothelium is necessary to protect against cognitive decline. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X211045438. PMID 34515549 DOI: 10.1177/0271678X211045438 |
0.269 |
|
| 2000 |
Tong XK, Hamel E. Basal forebrain nitric oxide synthase (NOS)-containing neurons project to microvessels and NOS neurons in the rat neocortex: cellular basis for cortical blood flow regulation. The European Journal of Neuroscience. 12: 2769-80. PMID 10971619 DOI: 10.1046/j.1460-9568.2000.00158.x |
0.265 |
|
| 1979 |
Jolicoeur FB, Rondeau DB, Hamel E, Butterworth RF, Barbeau A. Measurement of Ataxia and Related Neurological Signs in the Laboratory Rat Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 6: 209-215. PMID 487313 DOI: 10.1017/S0317167100119663 |
0.261 |
|
| 2005 |
Tong X, Hamel E. Transforming growth factor-|[szlig]|1 (TGF-|[szlig]|1) alter endothelin-1 (ET-1)-induced contraction in brain vessels via upregulation of mitogen-activated protein kinase phosphatase 1 (MKP-1) and inactivation of P38 mitogen-activated protein kinase (P38 MAPK) Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0172 |
0.259 |
|
| 1995 |
Cohen Z, Ehret M, Maitre M, Hamel E. Ultrastructural analysis of tryptophan hydroxylase immunoreactive nerve terminals in the rat cerebral cortex and hippocampus: their associations with local blood vessels. Neuroscience. 66: 555-69. PMID 7644020 DOI: 10.1016/0306-4522(94)00625-F |
0.258 |
|
| 2021 |
Li L, Tong XK, Hosseini Kahnouei M, Vallerand D, Hamel E, Girouard H. Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer's Disease. Frontiers in Physiology. 12: 715446. PMID 34475828 DOI: 10.3389/fphys.2021.715446 |
0.256 |
|
| 2016 |
Trigiani LJ, Tong X, Royea J, Hamel E. Comparative Benefits Of Simvastatin And Exercise On Cognitive And Cerebrovascular Impairments Induced By High Cholesterol In Transforming Growth Factor-B1 Mice Alzheimers & Dementia. 12: 622. DOI: 10.1016/J.Jalz.2016.06.1242 |
0.251 |
|
| 2008 |
Hamel E, Nicolakakis N, Aboulkassim T, Ongali B, Tong XK. Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease Experimental Physiology. 93: 116-120. PMID 17911359 DOI: 10.1113/expphysiol.2007.038729 |
0.246 |
|
| 1998 |
Miyazawa N, Hamel E, Diksic M. Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods. Journal of Neuro-Oncology. 38: 19-26. PMID 9540054 DOI: 10.1023/A:1005933226966 |
0.239 |
|
| 2023 |
Haqqani AS, Mianoor Z, Star AT, Detcheverry FE, Delaney CE, Stanimirovic DB, Hamel E, Badhwar A. Proteome Profiling of Brain Vessels in a Mouse Model of Cerebrovascular Pathology. Biology. 12. PMID 38132326 DOI: 10.3390/biology12121500 |
0.238 |
|
| 2010 |
Papadopoulos P, Ongali B, Hamel E. Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease. Canadian Journal of Physiology and Pharmacology. 88: 652-60. PMID 20628431 DOI: 10.1139/Y10-042 |
0.232 |
|
| 2012 |
Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, Khanna P, Jain SC, Thakur SS, Ravindranath V. Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proceedings of the National Academy of Sciences of the United States of America. 109: 3510-5. PMID 22308347 DOI: 10.1073/Pnas.1112209109 |
0.229 |
|
| 2018 |
Ongali B, Nicolakakis N, Tong XK, Lecrux C, Imboden H, Hamel EE. Transforming growth factor-β1 (TGF-β1) induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor-mediated signaling pathways. Canadian Journal of Physiology and Pharmacology. PMID 29505736 DOI: 10.1139/cjpp-2017-0640 |
0.226 |
|
| 2017 |
Zimmer ER, Parent MJ, Souza DG, Leuzy A, Lecrux C, Kim HI, Gauthier S, Pellerin L, Hamel E, Rosa-Neto P. [(18)F]FDG PET signal is driven by astroglial glutamate transport. Nature Neuroscience. PMID 28135241 DOI: 10.1038/Nn.4492 |
0.223 |
|
| 2002 |
Hamel E, Vaucher E, Tong X, St-Georges M. Neuronal messengers as mediators of microvascular tone in the cerebral cortex International Congress Series. 1235: 267-276. DOI: 10.1016/S0531-5131(02)00193-0 |
0.216 |
|
| 2022 |
Tong XK, Royea J, Hamel E. Simvastatin rescues memory and granule cell maturation through the Wnt/β-catenin signaling pathway in a mouse model of Alzheimer's disease. Cell Death & Disease. 13: 325. PMID 35397630 DOI: 10.1038/s41419-022-04784-y |
0.215 |
|
| 2020 |
Royea J, Hamel E. Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets. Geroscience. PMID 32700176 DOI: 10.1007/s11357-020-00231-y |
0.215 |
|
| 1982 |
Hamel E, Krause DN, Roberts E. Characterization of glutamic acid decarboxylase activity in cerebral blood vessels Journal of Neurochemistry. 39: 842-849. PMID 7097288 DOI: 10.1111/J.1471-4159.1982.Tb07969.X |
0.203 |
|
| 2002 |
Pringsheim T, Magnoux E, Dobson CF, Hamel E, Aubé M. Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. Headache. 42: 787-92. PMID 12390642 DOI: 10.1046/J.1526-4610.2002.02181.X |
0.201 |
|
| 2021 |
Trigiani LJ, Lecrux C, Royea J, Lavoie JL, Lesage F, Pilote L, Hamel E. A Longitudinal Pilot Study on Cognition and Cerebral Hemodynamics in a Mouse Model of Preeclampsia Superimposed on Hypertension: Looking at Mothers and Their Offspring. Frontiers in Physiology. 12: 611984. PMID 33584345 DOI: 10.3389/fphys.2021.611984 |
0.181 |
|
| 1986 |
Waksman G, Hamel E, Delay-Goyet P, Roques B. Neuronal localization of the neutral endopeptidase ‘enkephalinase’ in rat brain revealed by lesions and autoradiography. The Embo Journal. 5: 3163-3166. DOI: 10.1002/j.1460-2075.1986.tb04624.x |
0.18 |
|
| 2008 |
Curtis JS, Cakiroglu HJ, Zehntner S, Hamel E, Bedell BJ. P1-075: 3d whole-brain perfusion MRI in APP Transgenic mice Alzheimer's & Dementia. 4: T228-T228. DOI: 10.1016/j.jalz.2008.05.661 |
0.175 |
|
| 2010 |
Badhwar A, Lerch JP, Sled JG, Hamel E. P2-448: Early treatment with pioglitazone in APP transgenic mice shows focal hippocampal volume increase related to improved cognitive performance Alzheimer's & Dementia. 6: e7-e7. DOI: 10.1016/j.jalz.2010.08.022 |
0.171 |
|
| 2008 |
Bernier LP, Ase AR, Tong X, Hamel E, Blais D, Zhao Q, Logothetis DE, Séguéla P. Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate. Molecular Pharmacology. 74: 785-92. PMID 18523136 DOI: 10.1124/Mol.108.047019 |
0.171 |
|
| 1981 |
Hamel E, Krause DN, Roberts E. Specific cerebrovascular localization of glutamate decarboxylase activity Brain Research. 223: 199-204. PMID 7284804 DOI: 10.1016/0006-8993(81)90824-6 |
0.162 |
|
| 2021 |
Lacalle-Aurioles M, Trigiani LJ, Bourourou M, Lecrux C, Hamel E. Alzheimer's disease and cerebrovascular pathology alter brain endothelial inward rectifier potassium (K 2.1) channels. British Journal of Pharmacology. PMID 34820829 DOI: 10.1111/bph.15751 |
0.154 |
|
| 1987 |
Waksman G, Hamel E, Delay-Goyet P, Roques BP. Neutral endopeptidase-24.11, μ and δ opioid receptors after selective brain lesions: an autoradiographic study Brain Research. 436: 205-216. PMID 2829989 DOI: 10.1016/0006-8993(87)91663-5 |
0.152 |
|
| 2005 |
Ase AR, Raouf R, Bélanger D, Hamel E, Séguéla P. Potentiation of P2X1 ATP-gated currents by 5-hydroxytryptamine 2A receptors involves diacylglycerol-dependent kinases and intracellular calcium. The Journal of Pharmacology and Experimental Therapeutics. 315: 144-54. PMID 15958718 DOI: 10.1124/Jpet.105.089045 |
0.147 |
|
| 2007 |
Kocharyan A, Fernandes P, Tong XK, Vaucher E, Hamel E. GABA released from specific subtypes of activated cortical interneurons contributes to the hemodynamic response to basal forebrain stimulation Journal of Cerebral Blood Flow and Metabolism. 27: BP05-01H. |
0.147 |
|
| 2014 |
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorganic & Medicinal Chemistry. 22: 3753-72. PMID 24890652 DOI: 10.1016/J.Bmc.2014.04.049 |
0.145 |
|
| 2002 |
Cholet N, Pellerin L, Magistretti PJ, Hamel E. Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cerebral Cortex (New York, N.Y. : 1991). 12: 515-25. PMID 11950769 DOI: 10.1093/Cercor/12.5.515 |
0.14 |
|
| 1986 |
Waksman G, Hamel E, Fournie-Zaluski MC, Roques BP. Autoradiographic comparison of the distribution of the neutral endopeptidase 'enkephalinase' and of μ and δ opioid receptors in rat brain Proceedings of the National Academy of Sciences of the United States of America. 83: 1523-1527. PMID 3006054 DOI: 10.1073/PNAS.83.5.1523 |
0.139 |
|
| 2007 |
Fernandes P, Kocharyan A, Vaucher E, Hamel E. Specific subsets of cortical GABA interneurons are involved in the neurovascular coupling response to whisker stimulation in the rat Journal of Cerebral Blood Flow and Metabolism. 27: BO12-03. |
0.138 |
|
| 2012 |
Romagnoli R, Baraldi PG, Salvador MK, Preti D, Aghazadeh Tabrizi M, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E, Bortolozzi R, Porcù E, Basso G, Viola G. Discovery and optimization of a series of 2-aryl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazoles as novel anticancer agents. Journal of Medicinal Chemistry. 55: 5433-45. PMID 22578111 DOI: 10.1021/jm300388h |
0.133 |
|
| 2008 |
LaVallee TM, Burke PA, Swartz GM, Hamel E, Agoston GE, Shah J, Suwandi L, Hanson AD, Fogler WE, Sidor CF, Treston AM. Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198 Molecular Cancer Therapeutics. 7: 1472-1482. PMID 18566218 DOI: 10.1158/1535-7163.MCT-08-0107 |
0.132 |
|
| 2015 |
Hamel EJ, Grewe BF, Parker JG, Schnitzer MJ. Cellular level brain imaging in behaving mammals: an engineering approach. Neuron. 86: 140-59. PMID 25856491 DOI: 10.1016/J.Neuron.2015.03.055 |
0.124 |
|
| 2016 |
Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents. Bioorganic & Medicinal Chemistry. PMID 26852340 DOI: 10.1016/J.Bmc.2016.01.007 |
0.123 |
|
| 2008 |
Thomas SL, Zhong D, Zhou W, Malik S, Liotta D, Snyder JP, Hamel E, Giannakakou P. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle (Georgetown, Tex.). 7: 2409-17. PMID 18682687 DOI: 10.4161/Cc.6410 |
0.123 |
|
| 2011 |
Flynn BL, Gill GS, Grobelny DW, Chaplin JH, Paul D, Leske AF, Lavranos TC, Chalmers DK, Charman SA, Kostewicz E, Shackleford DM, Morizzi J, Hamel E, Jung MK, Kremmidiotis G. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. Journal of Medicinal Chemistry. 54: 6014-27. PMID 21774499 DOI: 10.1021/jm200454y |
0.119 |
|
| 2014 |
Gangjee A, Pavana RK, Ihnat MA, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Hamel E, Bai R. Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential. Acs Medicinal Chemistry Letters. 5: 480-4. PMID 24900865 DOI: 10.1021/Ml4004793 |
0.118 |
|
| 2007 |
Mooberry SL, Weiderhold KN, Dakshanamurthy S, Hamel E, Banner EJ, Kharlamova A, Hempel J, Gupton JT, Brown ML. Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole Molecular Pharmacology. 72: 132-140. PMID 17456786 DOI: 10.1124/Mol.107.034876 |
0.118 |
|
| 2021 |
Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, ... ... Hamel E, et al. New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases. Frontiers in Aging Neuroscience. 13: 623751. PMID 33584250 DOI: 10.3389/fnagi.2021.623751 |
0.118 |
|
| 2014 |
Romagnoli R, Baraldi PG, Salvador MK, Chayah M, Camacho ME, Prencipe F, Hamel E, Consolaro F, Basso G, Viola G. Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents. European Journal of Medicinal Chemistry. 81: 394-407. PMID 24858544 DOI: 10.1016/j.ejmech.2014.05.028 |
0.117 |
|
| 2011 |
Romagnoli R, Baraldi PG, Lopez Cara C, Kimatrai Salvador M, Bortolozzi R, Basso G, Viola G, Balzarini J, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E. One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent. European Journal of Medicinal Chemistry. 46: 6015-24. PMID 22027100 DOI: 10.1016/j.ejmech.2011.10.013 |
0.115 |
|
| 2015 |
Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents. Bioorganic & Medicinal Chemistry. 23: 2408-23. PMID 25882519 DOI: 10.1016/J.Bmc.2015.03.061 |
0.115 |
|
| 2012 |
Tanpure RP, George CS, Sriram M, Strecker TE, Tidmore JK, Hamel E, Charlton-Sevcik AK, Chaplin DJ, Trawick ML, Pinney KG. An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity. Medchemcomm. 3: 720-724. PMID 23772309 DOI: 10.1039/C2Md00318J |
0.115 |
|
| 2012 |
Romagnoli R, Baraldi PG, Salvador MK, Preti D, Aghazadeh Tabrizi M, Brancale A, Fu XH, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, Viola G. Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity. Journal of Medicinal Chemistry. 55: 475-88. PMID 22136312 DOI: 10.1021/jm2013979 |
0.114 |
|
| 2014 |
Porcù E, Sipos A, Basso G, Hamel E, Bai R, Stempfer V, Udvardy A, Bényei AC, Schmidhammer H, Antus S, Viola G. Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation. European Journal of Medicinal Chemistry. 84: 476-90. PMID 25050880 DOI: 10.1016/j.ejmech.2014.07.050 |
0.114 |
|
| 2015 |
Romagnoli R, Baraldi PG, Salvador MK, Prencipe F, Lopez-Cara C, Schiaffino Ortega S, Brancale A, Hamel E, Castagliuolo I, Mitola S, Ronca R, Bortolozzi R, Porcù E, Basso G, Viola G. Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin. Journal of Medicinal Chemistry. 58: 3209-22. PMID 25785605 DOI: 10.1021/acs.jmedchem.5b00155 |
0.112 |
|
| 1985 |
Hamel E, Beaudet A. Localization of opioid binding sites in rat brain by electron microscopic radioautography : J. Electr. Microsc. Techn., 1 (1984) 317–329 Pain. 22: 218. DOI: 10.1016/0304-3959(85)90216-7 |
0.112 |
|
| 2013 |
Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, et al. Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. Journal of Natural Products. 76: 1668-78. PMID 24016002 DOI: 10.1021/Np400374W |
0.111 |
|
| 2011 |
Romagnoli R, Baraldi PG, Lopez-Cara C, Cruz-Lopez O, Carrion MD, Kimatrai Salvador M, Bermejo J, Estévez S, Estévez F, Balzarini J, Brancale A, Ricci A, Chen L, Kim JG, Hamel E. Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis. Chemmedchem. 6: 1841-53. PMID 21805646 DOI: 10.1002/Cmdc.201100279 |
0.111 |
|
| 2013 |
Romagnoli R, Baraldi PG, Kimatrai Salvador M, Preti D, Aghazadeh Tabrizi M, Bassetto M, Brancale A, Hamel E, Castagliuolo I, Bortolozzi R, Basso G, Viola G. Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. Journal of Medicinal Chemistry. 56: 2606-18. PMID 23445496 DOI: 10.1021/jm400043d |
0.109 |
|
| 1981 |
Hamel E, Goetz IE, Roberts E. Glutamic acid decarboxylase and gamma-aminobutyric acid in Huntington's disease fibroblasts and other cultured cells, determined by a [3H]muscimol radioreceptor assay. Journal of Neurochemistry. 37: 1032-1038. PMID 6275031 DOI: 10.1111/J.1471-4159.1981.Tb04491.X |
0.109 |
|
| 2009 |
Bai R, Edler MC, Bonate PL, Copeland TD, Pettit GR, Ludueña RF, Hamel E. Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Molecular Pharmacology. 75: 218-26. PMID 18927208 DOI: 10.1124/Mol.108.051110 |
0.108 |
|
| 2014 |
Margarucci L, Monti MC, Esposito R, Tosco A, Hamel E, Riccio R, Casapullo A. N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization. Molecular Biosystems. 10: 862-7. PMID 24493364 DOI: 10.1039/C3Mb70315K |
0.108 |
|
| 2013 |
Lin YC, Tsai JY, Yang JS, Lee YH, Hamel E, Lee KH, Kuo SC, Huang LJ. The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells. International Journal of Oncology. 43: 1596-606. PMID 23970288 DOI: 10.3892/ijo.2013.2069 |
0.108 |
|
| 2013 |
Romagnoli R, Baraldi PG, Lopez-Cara C, Preti D, Aghazadeh Tabrizi M, Balzarini J, Bassetto M, Brancale A, Fu XH, Gao Y, Li J, Zhang SZ, Hamel E, Bortolozzi R, Basso G, et al. Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. Journal of Medicinal Chemistry. 56: 9296-309. PMID 24164557 DOI: 10.1021/jm4013938 |
0.108 |
|
| 2012 |
Calvo E, Barasoain I, Matesanz R, Pera B, Camafeita E, Pineda O, Hamel E, Vanderwal CD, Andreu JM, López JA, Díaz JF. Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site. Biochemistry. 51: 329-41. PMID 22148836 DOI: 10.1021/Bi201380P |
0.107 |
|
| 2007 |
Jimeno A, Hallur G, Chan A, Zhang X, Cusatis G, Chan F, Shah P, Chen R, Hamel E, Garrett-Mayer E, Khan S, Hidalgo M. Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer. Molecular Cancer Therapeutics. 6: 1509-16. PMID 17483439 DOI: 10.1158/1535-7163.Mct-06-0592 |
0.107 |
|
| 2019 |
Sorond FA, Whitehead S, Arai K, Arnold D, Carmichael ST, De Carli C, Duering M, Fornage M, Flores-Obando RE, Graff-Radford J, Hamel E, Hess DC, Ihara M, Jensen MK, Markus HS, et al. Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging. Geroscience. PMID 31811528 DOI: 10.1007/s11357-019-00141-8 |
0.106 |
|
| 2011 |
La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, ... ... Hamel E, et al. Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. Journal of Medicinal Chemistry. 54: 8394-406. PMID 22044164 DOI: 10.1021/jm2012886 |
0.106 |
|
| 2010 |
Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G. Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues Journal of Medicinal Chemistry. 53: 4248-4258. PMID 20420439 DOI: 10.1021/jm100245q |
0.106 |
|
| 2009 |
La Regina G, Sarkar T, Bai R, Edler MC, Saletti R, Coluccia A, Piscitelli F, Minelli L, Gatti V, Mazzoccoli C, Palermo V, Mazzoni C, Falcone C, Scovassi AI, Giansanti V, ... ... Hamel E, et al. New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies Journal of Medicinal Chemistry. 52: 7512-7527. PMID 19601594 DOI: 10.1021/jm900016t |
0.105 |
|
| 2014 |
Romagnoli R, Baraldi PG, Lopez-Cara C, Salvador MK, Preti D, Tabrizi MA, Balzarini J, Nussbaumer P, Bassetto M, Brancale A, Fu XH, Yang-Gao, Li J, Zhang SZ, Hamel E, et al. Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents. Bioorganic & Medicinal Chemistry. 22: 5097-109. PMID 24398384 DOI: 10.1016/j.bmc.2013.12.030 |
0.105 |
|
| 2011 |
Bai R, Nguyen TL, Burnett JC, Atasoylu O, Munro MH, Pettit GR, Smith AB, Gussio R, Hamel E. Interactions of halichondrin B and eribulin with tubulin. Journal of Chemical Information and Modeling. 51: 1393-404. PMID 21539396 DOI: 10.1021/Ci200077T |
0.103 |
|
| 2012 |
Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Stefanelli C, Masotti L, Nguyen TL, Hamel E, Shoemaker RH. Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action. Journal of Medicinal Chemistry. 55: 2078-88. PMID 22283430 DOI: 10.1021/jm2012694 |
0.102 |
|
| 2009 |
Tanpure RP, Harkrider AR, Strecker TE, Hamel E, Trawick ML, Pinney KG. Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents. Bioorganic & Medicinal Chemistry. 17: 6993-7001. PMID 19733085 DOI: 10.1016/J.Bmc.2009.08.011 |
0.102 |
|
| 2007 |
La Regina G, Edler MC, Brancale A, Kandil S, Coluccia A, Piscitelli F, Hamel E, De Martino G, Matesanz R, Díaz JF, Scovassi AI, Prosperi E, Lavecchia A, Novellino E, Artico M, et al. Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry. 50: 2865-74. PMID 17497841 DOI: 10.1021/Jm061479U |
0.101 |
|
| 2014 |
Romagnoli R, Baraldi PG, Salvador MK, Prencipe F, Bertolasi V, Cancellieri M, Brancale A, Hamel E, Castagliuolo I, Consolaro F, Porcù E, Basso G, Viola G. Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles. Journal of Medicinal Chemistry. 57: 6795-808. PMID 25025853 DOI: 10.1021/jm5008193 |
0.1 |
|
| 2009 |
Diaz R, Nguewa PA, Diaz-Gonzalez JA, Hamel E, Gonzalez-Moreno O, Catena R, Serrano D, Redrado M, Sherris D, Calvo A. The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer British Journal of Cancer. 100: 932-940. PMID 19240717 DOI: 10.1038/sj.bjc.6604938 |
0.1 |
|
| 2015 |
La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, ... ... Hamel E, et al. New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. Journal of Medicinal Chemistry. PMID 26132075 DOI: 10.1021/acs.jmedchem.5b00310 |
0.099 |
|
| 2009 |
Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Tolomeo M, Grimaudo S, Cristina AD, Pipitone MR, Balzarini J, Zonta N, Brancale A, Hamel E. Design, synthesis and structure-activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization Bioorganic and Medicinal Chemistry. 17: 6862-6871. PMID 19736015 DOI: 10.1016/j.bmc.2009.08.027 |
0.099 |
|
| 2014 |
La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, ... ... Hamel E, et al. New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. Journal of Medicinal Chemistry. 57: 6531-52. PMID 25025991 DOI: 10.1021/jm500561a |
0.098 |
|
| 2012 |
Viola G, Bortolozzi R, Hamel E, Moro S, Brun P, Castagliuolo I, Ferlin MG, Basso G. MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochemical Pharmacology. 83: 16-26. PMID 21964343 DOI: 10.1016/J.Bcp.2011.09.017 |
0.098 |
|
| 2013 |
La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, ... ... Hamel E, et al. Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. Journal of Medicinal Chemistry. 56: 123-49. PMID 23214452 DOI: 10.1021/jm3013097 |
0.097 |
|
| 2010 |
Ferlin MG, Bortolozzi R, Brun P, Castagliuolo I, Hamel E, Basso G, Viola G. Synthesis and in vitro evaluation of 3H-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity Chemmedchem. 5: 1373-1385. PMID 20629070 DOI: 10.1002/cmdc.201000180 |
0.097 |
|
| 2012 |
Sarkar T, Nguyen TL, Su ZW, Hao J, Bai R, Gussio R, Qiu SX, Hamel E. Interaction of pseudolaric acid B with the colchicine site of tubulin. Biochemical Pharmacology. 84: 444-50. PMID 22634405 DOI: 10.1016/j.bcp.2012.05.014 |
0.096 |
|
| 2010 |
Kong Y, Wang K, Edler MC, Hamel E, Mooberry SL, Paige MA, Brown ML. A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent. Bioorganic & Medicinal Chemistry. 18: 971-7. PMID 20006519 DOI: 10.1016/J.Bmc.2009.11.003 |
0.096 |
|
| 2013 |
Vitorovi?-Todorovi? MD, Eri?-Nikoli? A, Kolundžija B, Hamel E, Risti? S, Jurani? IO, Drakuli? BJ. (E)-4-aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: design, antiproliferative activity and inhibition of tubulin polymerization. European Journal of Medicinal Chemistry. 62: 40-50. PMID 23353745 DOI: 10.1016/j.ejmech.2013.01.006 |
0.095 |
|
| 2015 |
Herdman CA, Devkota L, Lin CM, Niu H, Strecker TE, Lopez R, Liu L, George CS, Tanpure RP, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry. PMID 26775540 DOI: 10.1016/J.Bmc.2015.10.012 |
0.095 |
|
| 2014 |
Krasavin M, Sosnov AV, Karapetian R, Konstantinov I, Soldatkina O, Godovykh E, Zubkov F, Bai R, Hamel E, Gakh AA. Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype. Bioorganic & Medicinal Chemistry Letters. 24: 4477-81. PMID 25155551 DOI: 10.1016/j.bmcl.2014.07.089 |
0.094 |
|
| 2007 |
Shin Y, Fournier JH, Brückner A, Madiraju C, Balachandran R, Raccor BS, Edler MC, Hamel E, Sikorski RP, Vogt A, Day BW, Curran DP. Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers. Tetrahedron. 63: 8537-8562. PMID 18728696 DOI: 10.1016/J.Tet.2007.05.033 |
0.094 |
|
| 2011 |
Romagnoli R, Baraldi PG, Cruz-Lopez O, Tolomeo M, Di Cristina A, Pipitone RM, Grimaudo S, Balzarini J, Brancale A, Hamel E. Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives. Bioorganic & Medicinal Chemistry Letters. 21: 2746-51. PMID 21146985 DOI: 10.1016/j.bmcl.2010.11.083 |
0.094 |
|
| 2013 |
Dos Santos ED, Prado PC, de Carvalho WR, de Lima RV, Beatriz E A, de Lima DP, Hamel E, Dyba MA, Albuquerque S. SYNTHESIS AND BIOLOGICAL ACTIVITY OF SULFUR COMPOUNDS SHOWING STRUCTURAL ANALOGY WITH COMBRETASTATIN A-4. Quimica Nova. 36: 279-283. PMID 23766547 DOI: 10.1590/S0100-40422013000200014 |
0.093 |
|
| 2013 |
Wang XF, Wang SB, Ohkoshi E, Wang LT, Hamel E, Qian K, Morris-Natschke SL, Lee KH, Xie L. N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin. European Journal of Medicinal Chemistry. 67: 196-207. PMID 23867604 DOI: 10.1016/J.Ejmech.2013.06.041 |
0.093 |
|
| 2011 |
Nakagawa-Goto K, Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH. Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. Journal of Medicinal Chemistry. 54: 1244-55. PMID 21284385 DOI: 10.1021/Jm1011947 |
0.092 |
|
| 2010 |
Romagnoli R, Baraldi PG, Pavani MG, Cruz-Lopez O, Hamel E, Balzarini J, Brognara E, Zuccato C, Gambari R. Synthesis and cellular pharmacology studies of a series of 2-amino-3-aroyl-4-substituted thiophene derivatives. Medicinal Chemistry (ShäRiqah (United Arab Emirates)). 6: 329-43. PMID 21054275 DOI: 10.2174/157340610793563974 |
0.091 |
|
| 2014 |
Leese MP, Jourdan FL, Major MR, Dohle W, Hamel E, Ferrandis E, Fiore A, Kasprzyk PG, Potter BV. Tetrahydroisoquinolinone-based steroidomimetic and chimeric microtubule disruptors. Chemmedchem. 9: 85-108, 1. PMID 24124095 DOI: 10.1002/Cmdc.201300261 |
0.09 |
|
| 2012 |
Nguyen TL, Cera MR, Pinto A, Lo Presti L, Hamel E, Conti P, Gussio R, De Wulf P. Evading Pgp activity in drug-resistant cancer cells: a structural and functional study of antitubulin furan metotica compounds. Molecular Cancer Therapeutics. 11: 1103-11. PMID 22442310 DOI: 10.1158/1535-7163.MCT-11-1018 |
0.09 |
|
| 2015 |
Romagnoli R, Baraldi PG, Prencipe F, Lopez-Cara C, Rondanin R, Simoni D, Hamel E, Grimaudo S, Pipitone RM, Meli M, Tolomeo M. Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation. European Journal of Medicinal Chemistry. 108: 39-52. PMID 26629859 DOI: 10.1016/j.ejmech.2015.11.022 |
0.09 |
|
| 2011 |
Romagnoli R, Baraldi PG, Brancale A, Ricci A, Hamel E, Bortolozzi R, Basso G, Viola G. Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents. Journal of Medicinal Chemistry. 54: 5144-53. PMID 21663319 DOI: 10.1021/jm200392p |
0.089 |
|
| 2010 |
Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Tolomeo M, Grimaudo S, Cristina AD, Pipitone MR, Balzarini J, Brancale A, Hamel E. Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors Bioorganic and Medicinal Chemistry. 18: 5114-5122. PMID 20579891 DOI: 10.1016/j.bmc.2010.05.068 |
0.089 |
|
| 2013 |
Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Vieceli Dalla Sega F, Prata C, Nguyen TL, Bai R, Hamel E. Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action. European Journal of Medicinal Chemistry. 64: 603-12. PMID 23685944 DOI: 10.1016/j.ejmech.2013.03.033 |
0.089 |
|
| 2014 |
Baytas SN, Inceler N, Yilmaz A, Olgac A, Menevse S, Banoglu E, Hamel E, Bortolozzi R, Viola G. Synthesis, biological evaluation and molecular docking studies of trans-indole-3-acrylamide derivatives, a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. 22: 3096-104. PMID 24816066 DOI: 10.1016/J.Bmc.2014.04.027 |
0.088 |
|
| 2012 |
Romagnoli R, Baraldi PG, Salvador MK, Camacho ME, Preti D, Tabrizi MA, Bassetto M, Brancale A, Hamel E, Bortolozzi R, Basso G, Viola G. Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic & Medicinal Chemistry. 20: 7083-94. PMID 23117171 DOI: 10.1016/j.bmc.2012.10.001 |
0.088 |
|
| 2009 |
Pettit RK, Pettit GR, Hamel E, Hogan F, Moser BR, Wolf S, Pon S, Chapuis JC, Schmidt JM. E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. Bioorganic & Medicinal Chemistry. 17: 6606-12. PMID 19709889 DOI: 10.1016/J.Bmc.2009.07.076 |
0.088 |
|
| 2013 |
dos Santos Edos A, Hamel E, Bai R, Burnett JC, Tozatti CS, Bogo D, Perdomo RT, Antunes AM, Marques MM, Matos Mde F, de Lima DP. Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity. Bioorganic & Medicinal Chemistry Letters. 23: 4669-73. PMID 23810282 DOI: 10.1016/J.Bmcl.2013.06.009 |
0.088 |
|
| 2013 |
Gangjee A, Zaware N, Devambatla RK, Raghavan S, Westbrook CD, Dybdal-Hargreaves NF, Hamel E, Mooberry SL. Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells. Bioorganic & Medicinal Chemistry. 21: 891-902. PMID 23332369 DOI: 10.1016/J.Bmc.2012.12.010 |
0.087 |
|
| 2009 |
Edler MC, Yang G, Katherine Jung M, Bai R, Bornmann WG, Hamel E. Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity Archives of Biochemistry and Biophysics. 487: 98-104. PMID 19497297 DOI: 10.1016/j.abb.2009.05.014 |
0.087 |
|
| 2008 |
Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Tolomeo M, Grimaudo S, Di Cristina A, Pipitone MR, Balzarini J, Kandil S, Brancale A, Sarkar T, Hamel E. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry Letters. 18: 5041-5. PMID 18725179 DOI: 10.1016/j.bmcl.2008.08.006 |
0.087 |
|
| 2006 |
Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Molecular Pharmacology. 70: 1555-64. PMID 16887932 DOI: 10.1124/Mol.106.027847 |
0.086 |
|
| 2014 |
Dohle W, Leese MP, Jourdan FL, Chapman CJ, Hamel E, Ferrandis E, Potter BV. Optimisation of tetrahydroisoquinoline-based chimeric microtubule disruptors. Chemmedchem. 9: 1783-93. PMID 24819406 DOI: 10.1002/Cmdc.201402025 |
0.086 |
|
| 2013 |
Wang XF, Ohkoshi E, Wang SB, Hamel E, Bastow KF, Morris-Natschke SL, Lee KH, Xie L. Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. 21: 632-42. PMID 23274123 DOI: 10.1016/j.bmc.2012.11.047 |
0.086 |
|
| 2009 |
Chang YH, Hsu MH, Wang SH, Huang LJ, Qian K, Morris-Natschke SL, Hamel E, Kuo SC, Lee KH. Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly. Journal of Medicinal Chemistry. 52: 4883-91. PMID 19719238 DOI: 10.1021/Jm900456W |
0.086 |
|
| 2010 |
Romagnoli R, Baraldi PG, Cara CL, Hamel E, Basso G, Bortolozzi R, Viola G. Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents European Journal of Medicinal Chemistry. 45: 5781-5791. PMID 20933308 DOI: 10.1016/j.ejmech.2010.09.038 |
0.085 |
|
| 2013 |
Gakh AA, Sosnov AV, Krasavin M, Nguyen TL, Hamel E. Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole. Bioorganic & Medicinal Chemistry Letters. 23: 1262-8. PMID 23385208 DOI: 10.1016/j.bmcl.2013.01.007 |
0.085 |
|
| 2007 |
Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature Chemical Biology. 3: 117-25. PMID 17206139 DOI: 10.1038/Nchembio853 |
0.084 |
|
| 2008 |
Chinigo GM, Paige M, Grindrod S, Hamel E, Dakshanamurthy S, Chruszcz M, Minor W, Brown ML. Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. Journal of Medicinal Chemistry. 51: 4620-31. PMID 18610995 DOI: 10.1021/Jm800271C |
0.084 |
|
| 2009 |
Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Balzarini J, Hamel E, Canella A, Fabbri E, Gambari R, Basso G, Viola G. Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation Bioorganic and Medicinal Chemistry Letters. 19: 2022-2028. PMID 19250822 DOI: 10.1016/j.bmcl.2009.02.038 |
0.084 |
|
| 2010 |
Kozaka T, Nakagawa-Goto K, Shi Q, Lai CY, Hamel E, Bastow KF, Brossi A, Lee KH. Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents Bioorganic and Medicinal Chemistry Letters. 20: 4091-4094. PMID 20542428 DOI: 10.1016/j.bmcl.2010.05.081 |
0.084 |
|
| 2007 |
Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Preti D, Fruttarolo F, Pavani MG, Tabrizi MA, Tolomeo M, Grimaudo S, Di Cristina A, Balzarini J, Hadfield JA, Brancale A, Hamel E. Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization Journal of Medicinal Chemistry. 50: 2273-2277. PMID 17419607 DOI: 10.1021/jm070050f |
0.084 |
|
| 2008 |
Romagnoli R, Baraldi PG, Sarkar T, Cara CL, Lopez OC, Carrion MD, Preti D, Tolomeo M, Balzarini J, Hamel E. Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 4: 558-64. PMID 18991740 DOI: 10.2174/157340608786242007 |
0.084 |
|
| 2014 |
Wang XF, Guan F, Ohkoshi E, Guo W, Wang L, Zhu DQ, Wang SB, Wang LT, Hamel E, Yang D, Li L, Qian K, Morris-Natschke SL, Yuan S, Lee KH, et al. Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. Journal of Medicinal Chemistry. 57: 1390-402. PMID 24502232 DOI: 10.1021/Jm4016526 |
0.083 |
|
| 2015 |
Lesma G, Bassanini I, Bortolozzi R, Colletto C, Bai R, Hamel E, Meneghetti F, Rainoldi G, Stucchi M, Sacchetti A, Silvani A, Viola G. Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues. Organic & Biomolecular Chemistry. PMID 26467486 DOI: 10.1039/c5ob01882j |
0.083 |
|
| 2008 |
Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Sarkar T, Hamel E. Design, synthesis, and biological evaluation of thiophene analogues of chalcones. Bioorganic & Medicinal Chemistry. 16: 5367-76. PMID 18440234 DOI: 10.1016/j.bmc.2008.04.026 |
0.082 |
|
| 2008 |
Romagnoli R, Baraldi PG, Sarkar T, Carrion MD, Cruz-Lopez O, Lopez Cara C, Tolomeo M, Grimaudo S, Di Cristina A, Pipitone MR, Balzarini J, Gambari R, Ilaria L, Saletti R, Brancale A, ... Hamel E, et al. Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry. 16: 8419-26. PMID 18755591 DOI: 10.1016/j.bmc.2008.08.029 |
0.08 |
|
| 2015 |
Raffa D, Maggio B, Plescia F, Cascioferro S, Raimondi MV, Cancemi G, D'Anneo A, Lauricella M, Cusimano MG, Bai R, Hamel E, Daidone G. Synthesis, antiproliferative activity and possible mechanism of action of novel 2-acetamidobenzamides bearing the 2-phenoxy functionality. Bioorganic & Medicinal Chemistry. 23: 6305-16. PMID 26344588 DOI: 10.1016/j.bmc.2015.08.027 |
0.08 |
|
| 2013 |
Raffa D, Maggio B, Raimondi MV, Cusimano MG, Amico G, Carollo A, Conaldi PG, Bai R, Hamel E, Daidone G. 2-cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action. European Journal of Medicinal Chemistry. 65: 427-35. PMID 23747810 DOI: 10.1016/j.ejmech.2013.04.068 |
0.08 |
|
| 2008 |
Anchoori RK, Kortenhorst MS, Hidalgo M, Sarkar T, Hallur G, Bai R, Diest PJ, Hamel E, Khan SR. Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy. Journal of Medicinal Chemistry. 51: 5953-7. PMID 18778046 DOI: 10.1021/jm800203e |
0.08 |
|
| 2008 |
Cullen MD, Sarkar T, Hamel E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Inhibition of tubulin polymerization by select alkenyldiarylmethanes. Bioorganic & Medicinal Chemistry Letters. 18: 469-73. PMID 18083556 DOI: 10.1016/J.Bmcl.2007.11.114 |
0.078 |
|
| 2009 |
Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Basso G, Viola G, Khedr M, Balzarini J, Mahboobi S, Sellmer A, Brancale A, Hamel E. 2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization Journal of Medicinal Chemistry. 52: 5551-5555. PMID 19663386 DOI: 10.1021/jm9001692 |
0.078 |
|
| 1997 |
Vaucher E, Lacombe P, Hamel E. Le système cholinergique basalo-cortical : modulateur de la microcirculation du néocortex MéDecine/Sciences. 13: 534. DOI: 10.4267/10608/409 |
0.078 |
|
| 2010 |
Nguyen TL, Xu X, Gussio R, Ghosh AK, Hamel E. The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A. Journal of Chemical Information and Modeling. 50: 2019-28. PMID 21028850 DOI: 10.1021/Ci1002894 |
0.078 |
|
| 2015 |
Medellin DC, Zhou Q, Scott R, Hill RM, Frail RS, Dasari R, Ontiveros SJ, Pelly SC, van Otterlo WA, Betancourt T, Shuster CB, Hamel E, Bai R, LaBarbera DV, Rogelj S, et al. Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent In Vitro and In Vivo Anticancer Activities. Journal of Medicinal Chemistry. PMID 26641132 DOI: 10.1021/Acs.Jmedchem.5B01426 |
0.077 |
|
| 2007 |
Kerr DJ, Hamel E, Jung MK, Flynn BL. The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4 Bioorganic and Medicinal Chemistry. 15: 3290-3298. PMID 17360188 DOI: 10.1016/j.bmc.2007.02.006 |
0.077 |
|
| 2010 |
Romagnoli R, Baraldi PG, Cruz-Lopez O, Cara CL, Carrion MD, Balzarini J, Hamel E, Basso G, Bortolozzi R, Viola G. Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation Bioorganic and Medicinal Chemistry Letters. 20: 2733-2739. PMID 20378350 DOI: 10.1016/j.bmcl.2010.03.075 |
0.077 |
|
| 2013 |
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, et al. Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids. Journal of Medicinal Chemistry. 56: 6886-900. PMID 23927793 DOI: 10.1021/Jm400711T |
0.077 |
|
| 2015 |
Nakagawa-Goto K, Oda A, Hamel E, Ohkoshi E, Lee KH, Goto M. Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring. Journal of Medicinal Chemistry. 58: 2378-89. PMID 25695315 DOI: 10.1021/jm501859j |
0.076 |
|
| 2013 |
Gangjee A, Zhao Y, Raghavan S, Rohena CC, Mooberry SL, Hamel E. Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents. Journal of Medicinal Chemistry. 56: 6829-44. PMID 23895532 DOI: 10.1021/Jm400639Z |
0.076 |
|
| 2011 |
Kanakkanthara A, Wilmes A, O'Brate A, Escuin D, Chan A, Gjyrezi A, Crawford J, Rawson P, Kivell B, Northcote PT, Hamel E, Giannakakou P, Miller JH. Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes. Molecular Cancer Therapeutics. 10: 1419-29. PMID 21653684 DOI: 10.1158/1535-7163.Mct-10-1057 |
0.076 |
|
| 2012 |
Field JJ, Pera B, Calvo E, Canales A, Zurwerra D, Trigili C, Rodríguez-Salarichs J, Matesanz R, Kanakkanthara A, Wakefield SJ, Singh AJ, Jiménez-Barbero J, Northcote P, Miller JH, López JA, ... Hamel E, et al. Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules. Chemistry & Biology. 19: 686-98. PMID 22726683 DOI: 10.1016/j.chembiol.2012.05.008 |
0.076 |
|
| 2013 |
Macdonough MT, Strecker TE, Hamel E, Hall JJ, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006). Bioorganic & Medicinal Chemistry. 21: 6831-43. PMID 23993969 DOI: 10.1016/J.Bmc.2013.07.028 |
0.075 |
|
| 2014 |
Dohle W, Leese MP, Jourdan FL, Major MR, Bai R, Hamel E, Ferrandis E, Kasprzyk PG, Fiore A, Newman SP, Purohit A, Potter BV. Synthesis, antitubulin, and antiproliferative SAR of C3/C1-substituted tetrahydroisoquinolines. Chemmedchem. 9: 350-70. PMID 24436228 DOI: 10.1002/Cmdc.201300412 |
0.075 |
|
| 2011 |
Gangjee A, Zhao Y, Hamel E, Westbrook C, Mooberry SL. Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents. Journal of Medicinal Chemistry. 54: 6151-5. PMID 21786793 DOI: 10.1021/Jm2007722 |
0.074 |
|
| 2011 |
Raffa D, Maggio B, Plescia F, Cascioferro S, Plescia S, Raimondi MV, Daidone G, Tolomeo M, Grimaudo S, Di Cristina A, Pipitone RM, Bai R, Hamel E. Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides. European Journal of Medicinal Chemistry. 46: 2786-96. PMID 21530013 DOI: 10.1016/j.ejmech.2011.03.067 |
0.074 |
|
| 2009 |
Wilcox E, McGrath C, Blokhin AV, Gussio R, Hamel E. Evidence for a distinct ligand binding site on tubulin discovered through inhibition by GDP of paclitaxel-induced tubulin assembly in the absence of exogenous GTP. Archives of Biochemistry and Biophysics. 484: 55-62. PMID 19161972 DOI: 10.1016/j.abb.2008.12.022 |
0.073 |
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| 2014 |
Leese MP, Jourdan FL, Major MR, Dohle W, Thomas MP, Hamel E, Ferrandis E, Mahon MF, Newman SP, Purohit A, Potter BV. Synthesis, anti-tubulin and antiproliferative SAR of steroidomimetic dihydroisoquinolinones. Chemmedchem. 9: 798-812. PMID 24596315 DOI: 10.1002/Cmdc.201400017 |
0.073 |
|
| 2010 |
Screpanti E, Santaguida S, Nguyen T, Silvestri R, Gussio R, Musacchio A, Hamel E, de Wulf P. A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds Plos One. 5. PMID 20657644 DOI: 10.1371/journal.pone.0011603 |
0.071 |
|
| 2011 |
Tanpure RP, Nguyen BL, Strecker TE, Aguirre S, Sharma S, Chaplin DJ, Siim BG, Hamel E, Lippert JW, Pettit GR, Trawick ML, Pinney KG. Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1. Journal of Natural Products. 74: 1568-74. PMID 21718055 DOI: 10.1021/Np200104T |
0.07 |
|
| 2012 |
Ghosh AK, Cheng X, Bai R, Hamel E. Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy. European Journal of Organic Chemistry. 2012: 4130-4139. PMID 23606808 DOI: 10.1002/Ejoc.201200286 |
0.07 |
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| 2013 |
Ziv Y, Burns LD, Cocker ED, Hamel EO, Ghosh KK, Kitch LJ, El Gamal A, Schnitzer MJ. Long-term dynamics of CA1 hippocampal place codes. Nature Neuroscience. 16: 264-6. PMID 23396101 DOI: 10.1038/Nn.3329 |
0.07 |
|
| 2009 |
Romagnoli R, Baraldi PG, Carrion MD, Cruz-Lopez O, Cara CL, Preti D, Tabrizi MA, Balzarini J, Hamel E, Fabbri E, Gambari R. Discovery of 8-methoxypyrazino[1,2-a]indole as a new potent antiproliferative agent against human leukemia K562 cells. A structure-activity relationship study Letters in Drug Design and Discovery. 6: 298-303. DOI: 10.2174/157018009788452519 |
0.07 |
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| 2013 |
Elagawany M, Schmitt M, Ghiaty A, El-Etrawy ASh, Ibrahim MA, Bihel F, Sbardelotto AB, Pessoa C, Nguyen TL, Hamel E, Bourguignon JJ. Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues. Anti-Cancer Agents in Medicinal Chemistry. 13: 1133-40. PMID 23574386 |
0.069 |
|
| 2012 |
Pettit GR, Rosenberg HJ, Dixon R, Knight JC, Hamel E, Chapuis JC, Pettit RK, Hogan F, Sumner B, Ain KB, Trickey-Platt B. Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. Journal of Natural Products. 75: 385-93. PMID 22324723 DOI: 10.1021/Np200797X |
0.068 |
|
| 2010 |
Jourdan F, Leese MP, Dohle W, Hamel E, Ferrandis E, Newman SP, Purohit A, Reed MJ, Potter BV. Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate. Journal of Medicinal Chemistry. 53: 2942-51. PMID 20225862 DOI: 10.1021/Jm9018806 |
0.066 |
|
| 2012 |
Leese MP, Jourdan F, Dohle W, Kimberley MR, Thomas MP, Bai R, Hamel E, Ferrandis E, Potter BV. Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors. Acs Medicinal Chemistry Letters. 3: 5-9. PMID 22247790 DOI: 10.1021/Ml200232C |
0.065 |
|
| 2015 |
Carta D, Bortolozzi R, Hamel E, Basso G, Moro S, Viola G, Ferlin MG. Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity. Journal of Medicinal Chemistry. 58: 7991-8010. PMID 26418966 DOI: 10.1021/Acs.Jmedchem.5B00805 |
0.064 |
|
| 2010 |
Gangjee A, Zhao Y, Lin L, Raghavan S, Roberts EG, Risinger AL, Hamel E, Mooberry SL. Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. Journal of Medicinal Chemistry. 53: 8116-28. PMID 20973488 DOI: 10.1021/Jm101010N |
0.062 |
|
| 2008 |
Romagnoli R, Baraldi PG, Sarkar T, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tabrizi MA, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Hsieh HP, ... Hamel E, et al. Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors. Journal of Medicinal Chemistry. 51: 1464-8. PMID 18260616 DOI: 10.1021/jm7011547 |
0.062 |
|
| 2015 |
Foucaud J, Oiry E, Flück C, Hamel E, Visser A. [Therapeutic education coordination function and skills]. Santé Publique (Vandoeuvre-LèS-Nancy, France). 27: S51-60. PMID 26168617 |
0.062 |
|
| 2014 |
Lesma G, Sacchetti A, Bai R, Basso G, Bortolozzi R, Hamel E, Silvani A, Vaiana N, Viola G. Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation. Molecular Diversity. 18: 357-73. PMID 24500310 DOI: 10.1007/s11030-014-9507-9 |
0.061 |
|
| 2009 |
Barbosa EG, Bega LA, Beatriz A, Sarkar T, Hamel E, do Amaral MS, de Lima DP. A diaryl sulfide, sulfoxide, and sulfone bearing structural similarities to combretastatin A-4. European Journal of Medicinal Chemistry. 44: 2685-8. PMID 19135763 DOI: 10.1016/j.ejmech.2008.12.018 |
0.061 |
|
| 2010 |
Singh AJ, Xu CX, Xu X, West LM, Wilmes A, Chan A, Hamel E, Miller JH, Northcote PT, Ghosh AK. Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. The Journal of Organic Chemistry. 75: 2-10. PMID 19957922 DOI: 10.1021/Jo9021265 |
0.061 |
|
| 2014 |
Marzaro G, Coluccia A, Ferrarese A, Brun P, Castagliuolo I, Conconi MT, La Regina G, Bai R, Silvestri R, Hamel E, Chilin A. Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors. Journal of Medicinal Chemistry. 57: 4598-605. PMID 24801610 DOI: 10.1021/jm500034j |
0.06 |
|
| 2015 |
Wang SB, Wang XF, Qin B, Ohkoshi E, Hsieh KY, Hamel E, Cui MT, Zhu DQ, Goto M, Morris-Natschke SL, Lee KH, Xie L. Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. PMID 26242242 DOI: 10.1016/j.bmc.2015.07.016 |
0.059 |
|
| 2012 |
Gangjee A, Pavana RK, Li W, Hamel E, Westbrook C, Mooberry SL. Novel water-soluble substituted pyrrolo[3,2-d]pyrimidines: design, synthesis, and biological evaluation as antitubulin antitumor agents. Pharmaceutical Research. 29: 3033-9. PMID 22814902 DOI: 10.1007/S11095-012-0816-3 |
0.059 |
|
| 2015 |
Nicolaou KC, Rhoades D, Wang Y, Totokotsopoulos S, Bai R, Hamel E. Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. Chemmedchem. PMID 26447977 DOI: 10.1002/Cmdc.201500401 |
0.059 |
|
| 2015 |
Kale SS, Jedhe GS, Meshram SN, Santra MK, Hamel E, Sanjayan GJ. Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity. Bioorganic & Medicinal Chemistry Letters. 25: 1982-5. PMID 25817588 DOI: 10.1016/J.Bmcl.2015.03.019 |
0.058 |
|
| 2008 |
Bai R, Vanderwal CD, Díaz JF, Hamel E. Interaction of a cyclostreptin analogue with the microtubule taxoid site: the covalent reaction rapidly follows binding. Journal of Natural Products. 71: 370-4. PMID 18298077 DOI: 10.1021/Np800056M |
0.057 |
|
| 2012 |
Tozatti CS, Khodyuk RG, da Silva AO, Dos Santos ED, de Lima MS, Hamel E. SYNTHESIS AND BIOLOGICAL EVALUATION OF BIARYL ANALOGS OF ANTITUBULIN COMPOUNDS. Quimica Nova. 35: 1758-1762. PMID 23087491 DOI: 10.1590/S0100-40422012000900010 |
0.056 |
|
| 2012 |
Dong S, Qin T, Hamel E, Beutler JA, Porco JA. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation. Journal of the American Chemical Society. 134: 19782-7. PMID 23110297 DOI: 10.1021/Ja3084708 |
0.055 |
|
| 2010 |
Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Casolari A, Hamel E, Fabbri E, Gambari R. Synthesis and evaluation of haloacetyl, α-bromoacryloyl and nitrooxyacetyl benzo[b]furan and benzo[b]thiophene derivatives as potent antiproliferative agents against leukemia l1210 and K562 cells Letters in Drug Design and Discovery. 7: 476-486. DOI: 10.2174/157018010791526296 |
0.054 |
|
| 2008 |
Li P, Evans CD, Wu Y, Cao B, Hamel E, Joullié MM. Evolution of the total syntheses of ustiloxin natural products and their analogues. Journal of the American Chemical Society. 130: 2351-64. PMID 18229928 DOI: 10.1021/Ja710363P |
0.054 |
|
| 2011 |
Joullié MM, Berritt S, Hamel E. Structure-activity relationships of ustiloxin analogues. Tetrahedron Letters. 52: 2136-2139. PMID 21607116 DOI: 10.1016/j.tetlet.2010.11.165 |
0.049 |
|
| 2009 |
Pettit GR, Quistorf PD, Fry JA, Herald DL, Hamel E, Chapuis JC. Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2. Journal of Natural Products. 72: 876-83. PMID 20161135 DOI: 10.1021/Np800635H |
0.048 |
|
| 2009 |
Dong S, Hamel E, Bai R, Covell DG, Beutler JA, Porco JA. Enantioselective synthesis of (+)-chamaecypanone C: a novel microtubule inhibitor. Angewandte Chemie (International Ed. in English). 48: 1494-7. PMID 19140149 DOI: 10.1002/Anie.200805486 |
0.048 |
|
| 2007 |
Romagnoli R, Baraldi PG, Remusat V, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Fruttarolo F, Tabrizi MA, Balzarini J, Hamel E. Synthesis and biological evaluation of 2-amino-3-(3′, 4′, 5′-trimethoxyphenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents Medicinal Chemistry. 3: 507-512. PMID 18045199 DOI: 10.2174/157340607782360380 |
0.046 |
|
| 2010 |
Ghosh AK, Dawson ZL, Moon DK, Bai R, Hamel E. Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs. Bioorganic & Medicinal Chemistry Letters. 20: 5104-7. PMID 20678932 DOI: 10.1016/J.Bmcl.2010.07.023 |
0.046 |
|
| 2008 |
Fang Z, Song Y, Sarkar T, Hamel E, Fogler WE, Agoston GE, Fanwick PE, Cushman M. Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors. The Journal of Organic Chemistry. 73: 4241-4. PMID 18447388 DOI: 10.1021/Jo800428B |
0.044 |
|
| 2014 |
Brodie M, Deane C, Hamel EC, Herrmann M, Ben-Porath E. Interviewing in disaster-affected areas: Lessons learned from post-Katrina surveys of New Orleans residents Hard-to-Survey Populations. 157-179. DOI: 10.1017/CBO9781139381635.011 |
0.04 |
|
| 2013 |
Jedhe GS, Paul D, Gonnade RG, Santra MK, Hamel E, Nguyen TL, Sanjayan GJ. Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues. Bioorganic & Medicinal Chemistry Letters. 23: 4680-4. PMID 23809851 DOI: 10.1016/J.Bmcl.2013.06.004 |
0.039 |
|
| 2010 |
Brodie M, Altman D, Deane C, Buscho S, Hamel E. Liking the pieces, not the package: Contradictions in public opinion during health reform Health Affairs. 29: 1125-1130. PMID 20530341 DOI: 10.1377/hlthaff.2010.0434 |
0.036 |
|
| 2015 |
Foucaud J, Oiry E, Flück C, Hamel E, Visser A. Therapeutic education coordination function and skills | Fonction et compétences de coordination en éducation thérapeutique Sante Publique. 27: S51-S60. |
0.03 |
|
| 2011 |
Stephens D, Morgan DN, DeFord DE, Donnelly A, Hamel E, Keith KJ, Brink DA, Johnson R, Seaman M, Young J, Gallant DJ, Hao S, Leigh SR. The impact of literacy coaches on teachers' beliefs and practices Journal of Literacy Research. 43: 215-249. DOI: 10.1177/1086296X11413716 |
0.025 |
|
| 2013 |
Léveillé G, Hamel E. A compound renewal model for medical malpractice insurance European Actuarial Journal. 3: 471-490. DOI: 10.1007/s13385-013-0080-x |
0.021 |
|
| 2015 |
Fassiotto M, Hamel EO, Ku M, Correll S, Grewal D, Lavori P, Periyakoil VJ, Reiss A, Sandborg C, Walton G, Winkleby M, Valantine H. Women in Academic Medicine: Measuring Stereotype Threat Among Junior Faculty. Journal of Women's Health (2002). PMID 26555562 DOI: 10.1089/Jwh.2015.5380 |
0.018 |
|
| 2009 |
Carrion L, Hamel E, Leblanc-Hotte A, Boudoux C, Guenat O, Maciejko R. Characterization of microfluidic systems with doppler optical coherence tomography Proceedings of Spie - the International Society For Optical Engineering. 7386. DOI: 10.1117/12.839798 |
0.017 |
|
| 2008 |
Derbanne Q, Leguen JF, Dupau T, Hamel E. Long-term non-linear bending moment prediction Proceedings of the International Conference On Offshore Mechanics and Arctic Engineering - Omae. 2: 313-322. DOI: 10.1115/OMAE2008-57326 |
0.012 |
|
| 2015 |
Foucaud J, Oiry E, Flück C, Hamel E, Visser A. [In Process Citation]. Santé Publique (Vandoeuvre-LèS-Nancy, France). 1: 51-60. PMID 26414257 |
0.01 |
|
| 2014 |
Foucaud J, Hamel E. [Health education: multidisciplinary key skills]. Santé Publique (Vandoeuvre-LèS-Nancy, France). 26: 173-82. PMID 25108958 |
0.01 |
|
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